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Rozprawy doktorskie na temat „Teladorsagia circumcincta”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 24 lipca 2025

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1

Richardson, Katherine. "Studies on the population dynamics of Teladorsagia circumcincta." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366339.

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2

Gasnier, Nadine. "Isolement du nématode teladorsagia circumcincta au sein des fermes caprines : influence sur la variabilité morphologique, écologique et génétique." Tours, 1994. http://www.theses.fr/1994TOUR4027.

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Les études épidémiologiques sont nombreuses sur ce parasite. Les travaux relatifs à l'écologie sont assez rares, ceux concernant la morphométrie ou la génétique, très rares. Des études antérieures ont montré l'isolement des fermes caprines en ce qui concerne les infestations par les helminthes. Les méthodes d'élevage sont très différentes selon les fermes, et les populations parasitaires pourraient être diversifiées. L'objet du présent travail est d'estimer la variabilité morphologique, écologique et génétique du nématode teladorsagia circumcincta. Quatorze populations de t. Circumcincta prove

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3

Dumas, Elodie Jacquiet Philippe. "Étude expérimentale d'infestations d'ovins par Oestrus ovis et Teladorsagia circumcincta." [S.l.] : [s.n.], 2008. http://oatao.univ-toulouse.fr/2128/1/debouch_2128.pdf.

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4

Goldfinch, Gillian Margaret. "Observations on the abomasal proteome during Teladorsagia circumcincta infection in sheep." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4804.

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Teladorsagia circumcincta is a major financial burden on the UK sheep farming industry. Disease control is becoming increasingly difficult due to the rapid emergence of anthelmintic resistance. This has prompted the search for alternative, sustainable control measures, including vaccination. Vaccine design would be aided by a thorough knowledge of the mechanisms involved in immunity to T.circumcincta. Most research has focussed on humoral and cellular responses to infection with this nematode. This thesis focuses on the impact of infection with regards to the proteins found locally within the

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5

Craig, Hannah L. "Characterisation of potentially host-protective material from the abomasal parasite, Teladorsagia circumcincta." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/14734.

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The main aims of this study were to identify and characterise proteins from <i>T. circumcincta </i>that may induce a protective immune response in the host and to learn more about the biology of the worm. In order to identify possible protective antigens, a complementary DNA (cDNA) library prepared from adult worms was screened with serum from an animal that was protected against a single challenge infection after vaccination with a <i>T. circumcincta </i>protein fraction (S3 TSBP). Forty five immunopositive cDNA clones were identified, of which sixteen had homology to galectin. Of the remaini

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6

Ellis, Samantha Emma Elizabeth. "Interactions of Teladorsagia circumcincta with the ovine immune system : mimicry and vaccine development." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9618.

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Teladorsagia circumcincta, an economically-important abomasal nematode of small ruminants in temperate regions worldwide, is currently controlled with a combination of anthelmintics and pasture management. Anthelmintic resistance has emerged and vaccination is a potential alternative control strategy, as protective immunity in sheep can be acquired after repeated exposure to the parasite. Abomasal mucosal IgA responses in immune sheep have been correlated with delayed worm development and reduced faecal egg counts. However, recombinant vaccine development against parasitic nematodes has had li

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7

Dicker, Alison Jane. "Comparative gene expression studies of anthelmintic resistance in the parasitic nematode, Teladorsagia circumcincta." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2223/.

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Anthelmintic resistance in parasitic nematodes of small ruminants is widespread and, in some parts of the world, threatens the sustainability of sheep production. The mechanisms whereby parasitic nematodes become resistant to anthelmintics, particularly ivermectin, remain to be determined. The majority of studies to date have investigated target site mutations; relatively little attention has been paid to the role of gene expression changes. The present study focused on Teladorsagia circumcincta; the predominant parasitic gastrointestinal nematode species in the UK and the predominant resistan

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8

Tzelos, Thomas. "RNA interference in parasitic nematodes : from genome to control." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15906.

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Teladorsagia circumcincta is a parasitic nematode which is a major cause of ovine parasitic gastroenteritis in temperate climatic regions. The parasite has developed resistance to the major anthelmintic drug classes and this challenges its future control. Vaccination is a potential alternative control method since sheep are able to develop protective immunity against this parasite. Although potential vaccine candidates have been revealed, the increasing gene datasets suggest that vaccinetarget selection may be aided by screening methods such as RNAi. This is a reverse genetic mechanism that ca

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9

Craig, Nicola Margaret. "Cytokine gene expression in naïve and previously infected sheep and lambs after challenge with the abomasal nematode Teladorsagia circumcincta." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4433.

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The abomasal helminth Teladorsagia circumcincta is one of the most economically important parasites to affect the farming of sheep and goats. T.circumcincta infection is particularly detrimental to lambs, in which it can cause pronounced morbidity and severe production losses. Due to the spreading resistance of this parasite to all currently available classes of anthelmintic drugs, it is having an increasingly severe impact on the sheep industry with significant implications for sheep welfare. Infection of sheep with T.circumcincta triggers local changes in the abomasum characteristic of a T h

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10

Halliday, Aileen. "Ruminant immunity to abomasal parasites." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8804.

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The studies submitted herein have contributed to our understanding of ruminant immunology, host-parasite interactions during ruminant infection with nematode parasites, and potential vaccine strategies to combat parasitic gastroenteritis (PGE). PGE of sheep and cattle, caused by T. circumcincta and O. ostertagia respectively, is a major problem for the global farming industry both in terms of productivity and animal welfare. To date control of these parasites has relied on the use of anthelmintic drugs however the emergence of widespread anthelmintic resistance is driving the search for altern

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11

Barrett, Martin. "Field studies on the control of a benzimidazole resistant isolate of Teladorsagia (Ostertagia) circumcincta." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360183.

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12

Grillo, Victoria Louise. "Development of microsatellites and the population genetic analysis of the parasitic nematode Teladorsagia circumcincta." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437971.

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13

Leignel, Vincent. "Diversité génétique et résistance aux benzimidazoles chez ""Teladorsagia circumcincta" (Nematoda, Trichostrongylidea) parasite de petits ruminants." Montpellier 2, 2000. http://www.theses.fr/2000MON20142.

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Mes travaux de these s'inserent dans le cadre general des recherches developpees sur la resistance aux benzimidazoles (bzs) chez teladorsagia circumcincta, trichostrongle parasite de petits ruminants. Dans une premiere partie, une etude sur la diversite genetique a tout d'abord montre que t. Circumcincta est en fait un complexe d'especes qui regroupe au moins deux especes distinctes t. Circumcincta et t. Goat. Elle a aussi mis en evidence chez t. Circumcincta (espece la plus frequente du complexe), une absence de structuration des populations a l'echelle regionale (< 200 km) et une faible stru

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14

Baker, Rachael Helen. "GTP-Cyclohydrolase function in parasitic nematode development." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6526.

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Parasitic nematodes of grazing livestock represent an increasing economic and welfare problem for British agriculture. By investigating specific life-cycle stages of these parasites, it may be possible to identify key molecules or pathways that are required for the survival of the worms, and thus exploit these for future control strategies. It has been shown previously that the third larval stages (L3) of the ovine parasitic nematode Teladorsagia circumcincta produce high levels of transcript for the enzyme GTP-Cyclohydrolase relative to later developmental stages. As the ratelimiting factor i

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15

Venturina, Virginia Mauro. "Relationship between an inflammatory mucosal T cell response and susceptibility of sheep to Teladorsagia circumcincta infection." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/8158.

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Control strategies against the parasitic nematode Teladorsagia circumcincta are problematic under current sheep management systems. Infection with the parasite, particularly in young lambs, results in significant production losses therefore sustainable worm control is being sought. It has been established that variation in resistance to T. circumcincta is under genetic control and the development of resistance is an acquired characteristic and has an immunological basis. This project investigated the immunological response to infection, of lambs with predicted resistance or susceptibility to T

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16

Longhi-Browne, Cassandra W. "Using Caenorhabditis elegans as a novel expression system for the generation of recombinant Teladorsagia circumcincta vaccine candidates." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5547/.

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Teladorsagia circumcincta is a common abomasal parasite of sheep in temperate regions and is one of the major causes of parasitic gastroenteritis (PGE) in growing lambs. Control of infection is achieved using anthelmintic drugs; however, this practice is rapidly becoming unsustainable due to widespread anthelmintic resistance within the T. circumcincta population. Sheep can acquire protective immunity against this parasite; immunity involves local and systemic antibodies and immune cells which can impair worm growth and fecundity and lead to expulsion of the parasites from the abomasum. Vaccin

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17

Turnbull, Francis. "P-Glycoprotein-9 and anthelmintic resistance status in selected UK strains of the ovine gastrointestinal nematode Teladorsagia circumcincta." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5173/.

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Throughout the world, control of parasitic nematodes in livestock has been compromised by the emergence and spread of anthelmintic resistance. Teladorsagia circumcincta is the most important gastrointestinal nematode parasite of small ruminants in temperate regions and the major resistant species in the United Kingdom (UK). In most cases the genetic factors which underpin resistance to broad-spectrum anthelmintics are still poorly understood. Recent work conducted independently in New Zealand (NZ) and Scotland has implicated the involvement of a particular P-glycoprotein (Pgp) gene, Tci-pgp-9,

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18

Sherriff, Andrea. "A mathematical study of environmental effects and genetic drug resistance on the life cycle of the nematode Teladorsagia circumcincta." Thesis, University of Strathclyde, 1996. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=20592.

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The parasitic nematode, Teladorsagia (Ostertagia) circumcincta is the primary cause of Parasitic Gastro-Enteritis (PGE) in lambs in Britain. Control of this parasite has largely depended on the use of broad spectrum anthelmintic drugs since their inception three decades ago. Widespread and unconstrained use of anthelmintics has resulted in selection for resistant strains of nematode, particularly within the T. circumcincta species. Control of PGE now involves optimizing parasite control whilst preserving the susceptibility of the parasites to the anti-parasitic drugs. Two aspects of the epidem

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19

Sparks, Alexandra Megan. "Evolutionary genetics of immunity to helminths in wild Soay sheep." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31109.

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Parasites have a major impact on host condition and fitness and thereby represent a strong selective force for individuals in wild populations. The main defence against parasite infection and associated morbidity is the host immune response, and consequently it is expected for there to be strong selection eroding genetic variation underlying immune responses in natural populations. However, studies in the wild have found considerable heritable variation underlying immune responses. Few studies have investigated the genetic variants underlying immunity in wild populations and are able to examin

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20

Henderson, Neil Gordon. "Immunity to Teladorsagia circumcincta infection in Scottish blackface sheep : an investigation into the kinetics of the immune response, antigen recognition and the MHC." Thesis, University of Glasgow, 2002. http://theses.gla.ac.uk/4140/.

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The kinetics of the host's immune responses to challenge infection were studied and identified clear patterns in plasma IgA activity, peripheral eosinophil counts, faecal egg counts and plasma pepsinogen concentrations but not in plasma IgG activity. It was determined that when used in parallel and when tested at multiple time points, these parameters have much greater potential as markers of resistance than when used individually or more importantly if only assessed on a single occasion. Further work investigated the recognition of stage specific parasite antigens by host plasma IgA by Wester

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21

Normand, Alexia Delannoy. "Recherche de gènes impliqués dans l'installation du strongle Haemonchus contortus par une approche transcriptomique." Thesis, Tours, 2010. http://www.theses.fr/2010TOUR4034/document.

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Parmi les nématodes gastro-intestinaux ayant un impact majeur sur la santé des ruminants Haemonchus contortus est l’espèce la plus pathogène. Actuellement, le contrôle des populations parasitaires repose sur les traitements anthelminthiques dont l’efficacité est limitée par l’émergence de parasites résistants. L'établissement de nouvelles stratégies de lutte (thérapeutiques ou vaccinales) repose actuellement sur l'identification de nouvelles cibles moléculaires. Ainsi, les gènes spécifiquement régulés lors de la phase précoce d’interaction du parasite H. contortus avec son hôte sont des cibles

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22

ELARD, LOIC. "La resistance aux benzimidazoles chez teladorsagia circumcincta, nematode parasite de petits ruminants. Etude du determinisme genetique et recherche des consequences sur la fitness des parasites." Tours, 1998. http://www.theses.fr/1998TOUR4018.

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La resistance aux benzimidazoles (bzs) chez t. Circumcincta, un nematode parasite de petits ruminants peut si aucune mesure limitant son developpement n'est preconisee, devenir un probleme majeur chez les eleveurs caprins et ovins. Les objectifs du travail realise furent donc d'etudier d'une part le determinisme genetique des mecanismes qui conferent une resistance aux bzs chez ce nematode et d'autre part d'effectuer une approche populationnelle de ce phenomene. Nous avons ainsi pu montrer que la resistance aux bzs chez t. Circumcincta semble principalement liee a une mutation sur le gene cibl

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23

Greer, Andrew Walter. "Estimates of the nutritional cost of the development of immunity to gastrointestinal parasites in sheep." Phd thesis, Lincoln University. Agriculture and Life Sciences Division, 2005. http://theses.lincoln.ac.nz/public/adt-NZLIU20060913.203642.

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This thesis describes a series of three experiments designed to estimate the nutritional cost of the immune response to the gastrointestinal nematodes Trichostrongylus colubriformis and Teladorsagia circumcincta in sheep. For each experiment, animals were allocated hierarchically by liveweight into one of four groups that were either infected (group IF), similarly infected and concurrently immuno-suppressed with weekly intramuscular injections of 1.3mg kg liveweight (LW)-1 of methylprednisolone acetate (group ISIF), immuno-suppressed only (group IS) or remained as controls (group C). Body co

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24

Brunken, Anja [Verfasser]. "Vergleichende Untersuchungen zur natürlichen Infektion mit Haemonchus contortus und Teladorsagia circumcincta sowie zu ausgewählten immunologischen und klinischen Parametern zwischen einer Hochleistungsschafrasse (Texel Schafe) und einer ursprünglichen, alten Haustierschafrasse (Soay Schafe) / Anja Brunken." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1117028380/34.

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25

Chylinski, Caroline. "Qu'est ce qui fait le succès des nématodes gastro-intestinaux chez leur hôte ? : Etude du rôle des nématodes, des moutons et des éleveurs." Thesis, Tours, 2014. http://www.theses.fr/2014TOUR4028/document.

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Le titre de la thèse concernant le succès des nématodes peut sembler extremement vaste. Notre projet était pourtant bien d’avoir une vue d’ensemble de l’ensemble des acteurs, à savoir les nématodes parasites du tube digestif mais également l’hôte et certains aspects de sa réponse, et enfin l’éleveur qui est celui qui décide du mode d’élevage et des traitements antiparasitaires. Nous avons essentiellement travaillé en conditions expérimentales et sur une espèce de ces strongles. En ce qui concerne les traits de vie des nématodes plusieurs grands phénomènes conditionnent leur succès : a) leur ca

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26

Stenhouse, Lindsay Joanne. "Characterisation of anthelmintic resistance in a multiple drug resistant Teladorsagia circumcinta isolate." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/4251/.

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The purpose of this study was to undertake detailed molecular and phenotypic characterisation of a MDR isolate of T. circumcincta (MTci5) with particular focus upon the mechanisms underlying benzimidazole (BZ) resistance. MTci5 was isolated from a farm in Central Scotland, which employed a suppressive anthelmintic dosing regime and was closed in 2002 when control of the parasite population became unsustainable. Underpinning all of the experiments in this study was an anthelmintic selection process whereby the MTci5 isolate was pressured individually with three broad-spectrum anthelmintics (b

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27

Greer, Andrew W. "Estimates of the nutritional cost of the development of immunity to gastrointestinal parasites in sheep." Lincoln University, 2005. http://hdl.handle.net/10182/11.

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This thesis describes a series of three experiments designed to estimate the nutritional cost of the immune response to the gastrointestinal nematodes Trichostrongylus colubriformis and Teladorsagia circumcincta in sheep. For each experiment, animals were allocated hierarchically by liveweight into one of four groups that were either infected (group IF), similarly infected and concurrently immuno-suppressed with weekly intramuscular injections of 1.3mg kg liveweight (LW)⁻¹ of methylprednisolone acetate (group ISIF), immunosuppressed only (group IS) or remained as controls (group C). Body compo

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28

Iposu, Shamsideen Oladeinde. "Effect of suckling on response to nematode parasites in young lambs." Diss., Lincoln University, 2007. http://hdl.handle.net/10182/115.

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The series of experiments described in this thesis were designed to investigate the role of suckling or late weaning in the response of young lambs to nematode infection. All experiments were conducted outdoors with grazing animals and no supplementation but for suckled groups of lambs whose counterparts were weaned to ryegrass – white clover swards. The parasite of interest was mainly Teladorsagia circumcincta solely but with mixed infection of Trichostrongylus colubriformis in one instance. In Chapter 3 (first experiment), the hypothesis that milk per se may have a direct effect on nematode

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29

Kamaludeen, Juriah. "Studies on the occurrence of anthelmintic resistance in goat parasites in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master of Veterinary Studies in Parasitology at Massey University, Palmerston North, New Zealand." 2010. http://hdl.handle.net/10179/1652.

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Two studies were conducted to investigate anthelmintic resistance in goat parasites in New Zealand. In Study 1 parasites from goats on a farm with a long history of problems with anthelmintic efficacy were used to infect sheep for a controlled slaughter study. Nineteen lambs were acquired, effectively drenched and housed. Each was infected with a mixture of larvae comprising Haemonchus contortus, Teladorsagia circumcincta, Trichostrongylus colubriformis and Oesophagostomum venulosum. After 28 days lambs were restrictively randomised into 3 groups based on faecal egg counts. Group 1 was left un

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