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Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Hirsch, Erica. "Telomerase activity and telomere lengths in fibroblast cells treated with ependymin peptide mimetics." Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-050505-134911/.

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Bestilny, Leslie James. "Regulation of telomere length and telomerase activity during aging and immortality." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0014/NQ38456.pdf.

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Betts, Dean Harvey. "Analysis of telomerase activity and telomere length during early bovine development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61967.pdf.

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Adekunle, Adesole A. "Evaluation of telomerase activity and telomerase inhibitors in Head and Neck cancer." Thesis, University of Bradford, 2019. http://hdl.handle.net/10454/17457.

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Cancer is a major cause of morbidity and mortality with increasing incidence worldwide. Early detection of cancers and better treatments would improve the outcome for patients. The overall 5-year survival rates of head and neck squamous cell carcinoma have not improved in the past several decades due to diagnosis at advanced stages and recurrent disease. Early detection and improved chemotherapy drugs are two key areas that are required to help to improve the prognosis for this disease. This thesis focuses on the enzyme telomerase which is known to contribute to one of the hallmarks of cancer

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Mills, Juliet Ann. "Telomerase activity in normal and malignant haematopoiesis." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417611.

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6

Lindkvist, Anna. "Activity and Regulation of Telomerase in Malignant Cells." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6623.

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<p>An important step in tumorgenesis is the acquisition of cellular immortality. Tumor cells accomplish this by activating the enzyme telomerase, and thereby avoiding replicative senescence. The aim of this thesis was to study the activity and regulation of telomerase in a panel of malignant cell types.</p><p>We found that TGF-β1 (transforming growth factor-β1) mediated differential effects on telomerase activity in five ATC (anaplastic thyroid carcinoma) cell lines. Cells that harbored a <i>p53</i> mutation responded by up-regulation of telomerase activity after TGF-β1 treatment, whereas cell

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Bermudez, Yira. "Growth Factor-Mediated Telomerase Activity in Ovarian Cancer Cells." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002028.

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Xu, Dawei. "Telomerase activity and its regulation in malignant hematopoietic cells /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3815-6/.

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9

Yu, Jie. "Microfluidic electrochemical detection of prostate cancer using telomerase activity." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/30528.

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Prostate cancer has become one of the leading causes of death and the most frequently diagnosed cancer in men, worldwide. It is highly treatable if detected early, but the current screening methods suffer from poor clinical specificity for prostate cancer, leading to unavoidable misdiagnosis and overtreatment. Elevated telomerase activity has been discovered as an indicator of a variety of cancers, including over 92 % of prostate cancers. High clinical specificity of telomerase activity for prostate cancer compared to other prostate anomalies is an important concept promoted in this thesis. To

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Flanary, Barry Eric. "Analysis of rat microglial cellular senescence as determined by measurements of telomere length and telomerase activity." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0009641.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 161 pages. Includes Vita. Includes bibliographical references.

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Izgi, Ahu. "Investigation Of Telomerase Activity And Gene Expression In Colorectal Cancer." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614409/index.pdf.

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Human telomerase is a reverse transcriptase which synthesizes telomeric repeat sequences at the ends of chromosomes. The telomerase enzyme has two essential subunits to be functional which are called telomerase reverse transcriptase (hTERT) and human telomerase RNA (hTR). Telomerase uses its RNA subunit as a template for the addition of hexameric repeats at the ends of chromosomes. The activity of telomerase has been detected in immortal cells but not in most normal somatic cells. Therefore, its activity could serve as diagnostic or prognostic marker in malignancies. Telomeres are heterochrom

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Carioto, Lisa M. "Telomerase activity in normal dogs and dogs with malignant lymphoma." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/NQ47384.pdf.

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Degerman, Sofie. "The immortalization process of T cells with focus on the regulation of telomere length and telomerase activity /." Doctoral thesis, Umeå : Umeå University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33466.

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TEDONE, ENZO. "LEUKOCYTE TELOMERE LENGTH, TELOMERASE ACTIVITY AND PREVALENCE OF AGE-RELATED DISEASES IN SEMISUPERCENTENARIANS, CENTENARIANS AND CENTENARIANS' OFFSPRING." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/263860.

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Centenarians and their offspring are increasingly considered a useful model to study and characterize the mechanisms underlying healthy aging and longevity. The aim of this project is to compare the prevalence of age-related diseases, telomere length (TL), a marker of biological age and mortality, and telomerase activity, an enzyme able to lengthen telomeres, across five groups of subjects: semisupercentenarians (SSCENT) (105–109 years old), centenarians (CENT) (100–104 years old), centenarians' offspring (CO), age- and gender-matched offspring of parents who both died at an age in linewith li

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Phipps, Sharla Marion Ostein. "Genetic and epigenetic modulation of telomerase activity in development and disease." Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/phipps.pdf.

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Thesis (Ph. D.)--University of Alabama at Birmingham, 2007.<br>Additional advisors: Vithal K. Ghanta, J. Michael Ruppert, Theresa V. Strong, R. Douglas Watson. Description based on contents viewed Oct. 3, 2008; title from PDF t.p. Includes bibliographical references.

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Eskiocak, Ugur. "Investigation Of Telomerase Activity In Diagnosis Of Endometrial And Cervical Cancer." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608507/index.pdf.

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Human telomerase is a ribonucleoprotein complex that adds hexameric TTAGGG repeats to the ends of chromosomes in order to prevent their shortening. Telomerase activity has been evaluated for its diagnostic and prognostic value in cancer since it is observed in most malignancies but not in most normal somatic tissues. In this study telomerase activity was examined in tumor specimens obtained from cervix, endometrium and their non-cancerous regions by an improved telomeric repeat amplification protocol (TRAP) &ndash<br>silver staining assay. Appearance of characteristic TRAP leader with 6 base

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Chomal, Manish R. "Analysis of telomerase activity and telomere lengths in human umbilical cord cell populations during ex vivo amplification of hematopoietic stem cells." Digital WPI, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-1205102-085840.

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Cressey, Timothy Roy. "Effects of DNA-interacting drugs on telomerase activity in human tumour cells." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300193.

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Murthy, Vidya. "Telomerase activity in human umbilical cord cell populations containing hematopoietic stem cells." Link to electronic thesis, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-0430102-105910.

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Xinarianos, George. "Genetic alterations in non-small cell lung carcinomas." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343688.

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Mosweu, Mpho. "Investigating the effects of RBBP6 gene expression on telomerase activity in cervical cancer." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/75200.

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Cancer remains a major health problem. It is ranked the second most common cause of death to cardiovascular diseases worldwide, with about 9.6 million deaths annually. This burden is greatly carried by developing countries, which are accountable for about 65% of cancer death worldwide. Retinoblastoma binding protein 6 (RBBP6) is one of the genes identified as proliferative gene that plays a role in cancer development. It has been shown together with telomerase activity to be highly increased in various cancer cells. E6 protein of human papillomavirus (HPV) and RBBP6 are known to enhance the pr

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Hukezalie, Kyle Reid. "Characterizing the effects of N/NRTIs on human telomerase activity in vitro and telomere maintenance in a transformed human cell model." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39773.

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Telomeres are nucleoprotein structures found at the ends of most linear chromosomes. Telomeric DNA shortens with each cell division, effectively restricting the proliferative capacity of most human cells. Telomerase, a specialized reverse transcriptase (RT), is responsible for de novo synthesis of telomeric DNA, and is the only physiological mechanism through which some human cells extend their telomere length. Disruption in telomerase activity results in accelerated telomere attrition, which manifests as a loss in tissue regenerative capacity. In individuals infected with the human immuno

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Jensen, Keith Douglas Ostergaard. "Dual Regulation of Telomerase Activity By HSF1 And Its Role in Prostate Cancer Progression." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1630.

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Deault-Bonin, Marie. "Microcell-mediated chromosome transfer shows that inhibition of telomerase activity occurs at the transcriptional level." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84503.

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We hypothesized that if normal cells carry a regulator which is inactivated in cancer cells, the transfer of this regulator from a normal cell to a cancerous one should inactivate the telomerase. Available in the laboratory was a panel of mouse/human microcell hybrids, each containing a tagged normal human chromosome fragment integrated into a mouse melanoma (telomerase-positive) background. We screened these hybrids for telomerase activity using both the polymerase chain reaction (PCR)-based telomeric repeat amplification protocol (TRAP) assay and mTERT mRNA amplification.<br>We were a

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Pedroso, Daiana Cristina Chielli. "Comprimento do telômero e atividade da telomerase em células do cumulus de mulheres com Síndrome dos Ovários Policísticos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-19072018-102713/.

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A Síndrome dos Ovários Policísticos (SOP) representa um dos distúrbios endócrinos reprodutivos mais comuns em mulheres em idade reprodutiva. As mulheres com SOP normalmente respondem bem ao tratamento de reprodução assistida (TRAs), mas frequentemente apresentam oócitos de baixa qualidade e capacidade reprodutiva, a qual está correlacionado com a interação do oócito com as células do cumulus. A baixa qualidade oocitária pode estar relacionada a perda de estabilidade genômica do oócito, ou até mesmo das células do cumulus, o que pode levar a uma redução gradativa da fertilidade feminina. Os tel

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Hasan, Rana. "Functional identification and mapping of a gene that represses telomerase hTERT transcription in prostate cancer cells." Thesis, Brunel University, 2010. http://bura.brunel.ac.uk/handle/2438/5683.

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Telomerase is present in over 90% of tumour tissues and immortalized cells and is tightly regulated in most normal somatic cells. This suggests the existence of regulatory mechanisms repressing telomerase in normal cells that somehow have become inactive during cancer development. In this project, I used genetic complementation in the form of microcell-mediated monochromosome transfer (MMCT) to search for chromosomes that repress telomerase activity in a prostate cancer cell line, PC-3. Microcell hybrids generated by introducing normal human chromosome 11 strongly inhibited telomerase. Telomer

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Ain, Quratul [Verfasser], Otto W. [Gutachter] Witte, Regine [Gutachter] Heller, and Thomas [Gutachter] Arendt. "Analysis of telomere length dynamics and telomerase activity in neurosenescence and neurodegenerative diseases of the central nervous system / Quratul Ain ; Gutachter: Otto W. Witte, Regine Heller, Thomas Arendt." Jena : Friedrich-Schiller-Universität Jena, 2018. http://d-nb.info/1170588433/34.

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Punder, Karin de [Verfasser]. "Characterization in humans of in vitro leukocyte maximal telomerase activity capacity (mTAC) and association with stress / Karin de Punder." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1170876706/34.

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Brannan, Katla Jorundsdottir. "Telomerase and its reverse transcriptase subunit TERT : identification and oestrogenic modulation of telomerase transcription in two aquatic test species - European Purple Sea Urchin (Paracentrotus Lividus) and Rainbow Trout (Oncorhynchus Mykiss)." Thesis, University of Exeter, 2012. http://hdl.handle.net/10871/16556.

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A plethora of naturally-produced steroid hormones, or artificial homologues of them, are being introduced into the aquatic and terrestrial environments each year. Two examples of these are the natural oestrogen 17ï¢-oestradiol (E2) and the oestrogen receptor antagonist, Bisphenol A (BPA), both of which target the ribonucleoprotein telomerase through upregulation of its telomerase reverse transcriptase component, TERT. The main objectives of this study were firstly to isolate and characterize the actual mRNA sequence for the telomerase catalytic subuninit, Tert, in rainbow trout (Oncorhynchus

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DUCRAY, CAROLINE. "Dynamique de la taille des telomeres, activite telomerase et instabilite chromosomique dans des cellules humaines." Paris 6, 1999. http://www.theses.fr/1999PA066166.

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La plupart des cellules somatiques presentent des capacites proliferatives limitees. La duree de vie des cellules serait programmee et en partie gouvernee par la taille des telomeres. Les sequences telomeriques, structures specialisees localisees a l'extremite des chromosomes, raccourcissent a chaque division mitotique. Un raccourcissement trop important des telomeres serait un signal de sortie du cycle cellulaire. Les cellules tumorales, caracterisees par une proliferation illimitee et anarchique, peuvent contourner ces arrets obligatoires. Un des mecanismes d'immortalisation des cellules pas

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Singh, Sanjleena. "Characterisation of mesenchymal cells from osteophytes in osteoarthritis." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/31298/1/Sanjleena_Singh_Thesis.pdf.

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Osteophytes form through the process of chondroid metamorphosis of fibrous tissue followed by endochondral ossification. Osteophytes have been found to consist of three different mesenchymal tissue regions including endochondral bone formation within cartilage residues, intra-membranous bone formation within fibrous tissue and bone formation within bone marrow spaces. All these features provide evidence of mesenchymal stem cells (MSC) involvement in osteophyte formation; nevertheless, it remains to be characterised. MSC from numerous mesenchymal tissues have been isolated but bone marrow remai

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Aloysius, Mark. "Anti-cancer vaccination with dendritic cells pulsed with class I and II peptides of human telomerase reverse transcriptase (hTERT) : optimization of anti-cancer cytotoxic T killer cell activity in patients with advanced malignancy." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546266.

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MARTORANA, Adriana. "B CELL CHANGES IN AGING." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/90990.

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The aging of the immune system is a gradual and dynamic process that modifies some immunological functions. These changes are known as “immunosenescence” that have a great impact on immune performance in late life, contributing to the decreased ability of the elderly people to respond to emerging pathogens and to the decreased responsiveness to vaccinations. It is known that the adaptive immune functions are affected in the aged. In particular, with aging, the acquired compartment of the immune system shows significant modifications in both T and B cell branches. Thus, the adaptive immune resp

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Reichert, Sophie. "Facteurs déterminant la longueur des télomères et implications dans les compromis évolutifs." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01023750.

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Une question fondamentale de la biologie évolutive porte sur la compréhension des mécanismes sous-tendant les processus évolutifs et l'évolution des compromis entre les traits d'histoire de vie. Parmi ces mécanismes, les télomères suscitent un intérêt particulier. Les télomères sont localisés à l'extrémité des chromosomes eucaryotes et participent à la sénescence cellulaire et au vieillissement des individus. La longueur des télomères est susceptible de donner des indications sur le mode de vie et l'état physiologique des organismes. Le but de cette thèse a été de comprendre quels sont les fac

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Piciocchi, Marika. "Danno ossidativo nucleare e mitocondriale e disfunzione telomerica nel processo di carcinogenesi epatica." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422632.

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Induction of chronic oxidative stress by hepatitis C (HCV) and B (HBV) virus is one of the molecular events leading to hepatocellular carcinoma (HCC) development. Telomeres are prone to oxidative modifications, that induce a progressive telomere shortening and a consequent chromosomal instability. Telomerase activity plays a crucial role in telomeres maintenance and cell immortalization. TERT, the rate limiting factor for telomerase transcription, is regulated by epigenetic mechanism and under oxidative stress migrates to mitochondria, where it ameliorates the membrane stability and exerts an

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Duret, Lou. "Comprendre comment la protéine PX régule les activités de la télomérase." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://www.theses.fr/2021COAZ6029.

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La télomérase est une ribonucléoprotéine qui joue deux rôles indépendants et critiques dans les cellules cancéreuses et dans les cellules souches adultes. En tant que transcriptase inverse qui synthétise les répétitions télomériques localisées à l’extrémité des chromosomes, la télomérase assure le maintien de la stabilité des télomères. Cette activité, dite canonique, permet de prévenir les conséquences néfastes liées à un dysfonctionnement des télomères. Afin d’ajouter les séquences télomériques aux extrémités des chromosomes, la télomérase nécessite sa sous-unité protéique TERT, et son compo

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Ludlow, Andrew Todd. "Relationship between physical activity and telomere maintenance in peripheral blood mononucleocytes." College Park, Md.: University of Maryland, 2007. http://hdl.handle.net/1903/7245.

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Thesis (M.A.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Dept. of Kinesiology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Castillo, Gonzalez Daimel. "Novel Quadruplex ligands : in silico and in vitro approaches." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22075/document.

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Les séquences d’ADN et d'ARN riches en Guanines peuvent adopter des conformations inhabituelles connues sous le nom de G-quadruplexes (G4). Les topologies et les formes de ces structures fascinantes sont très diverses. Les G4 sont stabilisés par la présence de cations monovalents et des liaisons Hydrogène de type Hoogsteen. De petites molécules contribuent également à la formation de formes stables, principalement par des interactions d'empilement π - π. Bien que les G4 soient connus depuis des décennies, l'intérêt de la communauté scientifique a été stimulé par la découverte de leur effet pot

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Savela, S. (Salla). "Physical activity in midlife and health-related quality of life, frailty, telomere length and mortality in old age." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206868.

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Abstract Physical inactivity is an increasing health problem worldwide and one of the most important risk factors for global premature mortality. Along with gained years, it is highly essential for both individuals and society that elderly persons perceive their health as good and are able to cope well with everyday life and enjoy it. Hence, our aim was to investigate the long-term associations of midlife physical activity (PA) with health-related quality of life (HRQL), frailty stage, leukocyte telomere length (LTL), a potential indicator of biological ageing, and mortality. The Helsinki Busi

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Soules, Aurélien. "Apports des activités chimiques et photochimiques des alkyls azides à la synthèse macromoléculaire." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2010. http://www.theses.fr/2010ENCM0001.

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L'objectif de ces travaux était d'utiliser certains aspects de l'activité chimique et photochimique de télomères fluorés porteurs de fonctions azides, dans le but de promouvoir les synthèses de polymères thermostables et de nouveaux matériaux photoréticulés. En premier lieu, nous avons développé et caractérisé une nouvelle classe de poly(alkyl-aryl) éthers par une promotion de la compétition de la réaction de « Click » et de couplage de Hay. Par la suite, l'activité photochimique de ces composés fluorés a été étudiée et utilisée pour élaborer des matériaux photoréticulés. Les énergies libres d

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Bakhos, Al Douaihy Dalal. "Implication des lysines acétyl transférases dans les mécanismes ALTernatifs de maintenance des télomères Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2322&f=12888.

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Certaines cellules cancéreuses peuvent utiliser un mécanisme indépendant de la télomérase, connu sous le nom ALT (Alternative Lengthening of Telomeres) pour allonger leurs télomères. Les cellules ALT sont caractérisées par des télomères hétérogènes extrêmement longs et d’autres très courts voire indétectables qui co-localisent avec les corps PML pour former des structures nucléaires appelées APB (ALT-associated PML Bodies), et une fréquence élevée d'échange entre les télomères des chromatides sœurs appelées T- SCE (Telomeric Sister Chromatid Exchange). Bien qu'il soit concevable que la recombi

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Silva, Léia Cristina Rodrigues da. "Impacto da prática da atividade física moderada regular no retardo da imunossenescência de idosos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-20042016-155531/.

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O aumento da expectativa de vida é um evento mundial e tem alterado a pirâmide populacional, com aumento da população idosa e redução da população jovem, tanto em países desenvolvidos como em desenvolvimento. De acordo com projeções das Nações Unidas realizadas em 2012, a população brasileira com idade superior a 65 anos atingirá a média de 50 milhões no ano de 2050. O avanço da idade acarreta mudanças na composição, função fisiológica e competência do sistema imunológico humano, as quais são definidas pelo termo imunossenescência. Essas mudanças são importantes, pois contribuem para um aument

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Matias, Manuella de Sousa Toledo. "Efeito da atividade física regular de alto desempenho aeróbico na resposta imune e no encurtamento do telômero em linfócitos T de idosos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5140/tde-12012016-085413/.

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INTRODUÇÃO: O aumento na expectativa de vida da população justifica o interesse em compreender melhor o processo de envelhecimento. Uma projeção recente do Instituto Brasileiro de Geografia e Estatística prevê que a população de idosos vai triplicar até 2050. Esse aumento trará para o sistema de saúde do Brasil um desafio. O aumento do número de doenças, o comprometimento imunológico, a diminuição da resposta às vacinas são evidenciados na população idosa. A associação entre encurtamento do telômero e senescência celular tem sido estabelecida laboratorialmente. Neste estudo avaliamos comparati

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Chen, Yu-Fan, and 陳昱帆. "Analyzing th effects of Saccharomyces cerevisiae telomere-associated proteins on telomerase activity." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/40778304559412498677.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>96<br>Telomeres are specialized protein-DNA structures at the physical ends of eukaryotic chromosomes. They are important for maintaining the stability of chromosomes. In yeast Saccharomyces cerevisiae, the telomere is composed of ~250-350 bp TG1-3/C1-3A double-stranded DNA and a single-stranded TG1-3 tail. Telomerase is a ribonucleoprotein involved in telomere replication and maintenance. Genetic evidence indicates that telomerase activity is regulated by telomere-associated protein factors, including Cdc13p, Ku proteins, and Est1p. Cdc13p is a single-stranded telom

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Hung, Ai-Ting, and 洪嬡婷. "Detection of plant telomerase activity during flowering stages." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/56130124454335546716.

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碩士<br>國立高雄師範大學<br>生物科學研究所<br>87<br>Telomeres are nucleoprotein structure at the ends of linear eukaryotic chromosomes that are essential for maintaining the integrity of the genome. The changes in telomere length may play an important role in the senescence of cells. Telomere is maintained by a special enzyme named telomerase. It is a ribonucleoprotein with a reverse transcriptase activity . Telomerase is a specialized DNA polymerase which is present in regenerating tissues. Hence , telomerase activation appears to be a conserved mechanism involved in conferring long-term proliferation capacit

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Diede, Scott John. "The regulation of telomerase activity in Saccharomyces cerevisiae /." 2001. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9997159.

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Chang, Lien-Yu, and 張蓮鈺. "Telomerase activity is an early event in oral carcinogenesis." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/81542177239582853660.

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"Relationship between serum corticosteroid level and telomere length/telomerase activity in spleen cells of Balb/c mice." 2007. http://library.cuhk.edu.hk/record=b5893247.

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Chiu, Wang Kei.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 95-110).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>摘要 --- p.iii<br>Contents --- p.v<br>Acknowledgements --- p.viii<br>Abbreviations --- p.ix<br>List of tables --- p.xii<br>List of figures --- p.xii<br>Chapter 1. --- Literature Review --- p.1<br>Chapter 1.1 --- Cell cycle and chromosome replication --- p.1<br>Chapter 1.2 --- Telomere-associated proteins --- p.4<br>Chapter 1.3 --- Telomere repair protein --- p.6<br>Chapter 1.4 --- Function of tel

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Hájek, Miroslav. "Modulation of human telomerase activity by nucleoside and nucleotide analogues." Doctoral thesis, 2008. http://www.nusl.cz/ntk/nusl-368977.

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CONCLUSIONS Considering human telomerase as a promising target of anti-cancer therapy, the thesis deals with the study of inhibitory potency of selected ANP diphosphates towards telomerase, and the capability of nucleoside-type DNA methylation inhibitors to inhibit hTERT expression, knowing that hTERT expression closely correlates with telomerase activity in vitro and in vivo. The results can be summarized as follows: All the purine ANP diphosphates except for (S)-PMPApp and 6-Me2PMEDAPpp show dose- dependent inhibition of human telomerase in cell-free assay, the adenine derivatives are less

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Liu, Le-Te, and 劉立德. "Telomerase activity in human urothelial carcinoma and its diagnostic application." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/38694848578946273247.

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碩士<br>高雄醫學院<br>醫學研究所<br>86<br>Telomerase have a vital role in maintaining chromosome stability and areessential for long term cellular viability. Since the very ends of linear chromosome cannot replicate, telomerase shorten in normal somatic cells eventually resulting in growth inhibition. However, most immortal cell lines maintain stable telomeres indicating that mechanism(s) exist to compensate forthe end replication problem. Telomerase is an RNA-dependent nucleoprotein enzyme capable o

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