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Rozprawy doktorskie na temat „Tetanus”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Farzad, Zohreh (Emami Aleagha). "Studies on anti-tetanus antibodies." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/23886.

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2

Lam, Nu Tra Mi Veena Sirisook. "A Predictive model of neonatal tetanus preventive intention among women in Nihn Phuoc district, Vietnam /." Abstract, 2008. http://mulinet3.li.mahidol.ac.th/thesis/2551/cd415/4938060.pdf.

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3

Michaelides, Alecos. "Chemical and enzymatic fragmentation of tetanus toxin and immunological studies on anti-tetanus toxin and toxoid sera." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9661.

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This thesis describes the immunization protocols for the production of antibodies against tetanus toxin and toxoid in guinea pigs and mice. Antibodies were successfully raised against the toxin without mortalities in either species. The murine sera obtained, were isotyped by ELISA and the toxin was proven to be a superior antigen in eliciting production of IgG$\rm\sb{2a}$ and IgG$\sb3$. The two isotypes which have demonstrated antitumor activity. The anti-toxoid sera exhibited a lower reactivity towards the toxin and toxoid when compared with anti-toxin sera. The reactivity of recombinant teta

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4

Saleh, Jalal-Eddeen Abubakar. "Prevalence of Neonatal Tetanus in Northeastern Nigeria." ScholarWorks, 2014. https://scholarworks.waldenu.edu/dissertations/166.

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Although efforts have been made towards improving the health of children across the globe with notable results, neonatal tetanus (NNT) remains a major contributor to the neonatal death rates in Nigeria. This problem calls for a concerted effort by the government to achieve the revised global NNT elimination deadline of 2015. The purpose of this cross-sectional quantitative study using secondary data was to establish the prevalence of NNT in Nigeria's northeast region and to ascertain if there was any significant difference in frequency of antenatal care (ANC), trained traditional birth attenda

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5

Brüggemann, Holger. "Die vollständige Entschlüsselung der Genomsequenz des Tetanus-Erregers Clostridium tetani und die Analyse seines genetischen Potentials." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=969514581.

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6

Thwaites, Catherine Louise. "Prognosis and treatment of tetanus in southern Vietnam." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419889.

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7

Johnston, Louise. "Transcutaneous immunisation with antigens derived from tetanus toxin." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4657.

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Transcutaneous immunisation (TCI) is a novel needle-free method of vaccine delivery, which involves the application of soluble antigens onto the surface of intact skin. In this thesis, the immunogenicity and neutralising potency of tetanus neurotoxin (TeNT) fragments were compared to that of tetanus toxoid (TTxd) following TCI. In addition, to understand the mechanisms of induction of immune response by TCI, in vitro and in vivo interaction of tetanus proteins with skin immune cells was also investigated. The 50kDa recombinant carboxyl-terminal fragment of tetanus toxin (HCWT) and a 50kDa HC m

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8

Sheppard, A. J. "Studies on production and characterisation of monoclonal antibodies to tetanus toxin, and their use for developing immunopurified tetanus toxoid and toxin." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235280.

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9

Whelan, Sarah Michelle. "Molecular characterisation and detection of clostridial neurotoxin genes." Thesis, Open University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357194.

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10

Nass, Shafique Sani. "Evaluation of Active and Passive Neonatal Tetanus Surveillance Systems in Katsina State, Nigeria." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2095.

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The incidence and mortality rates of neonatal tetanus (NNT) remain underreported in Nigeria. This cross-sectional study was guided by the Mosley and Chen's model for the elements of child survival in developing countries. The goals of the study were twofold: (a) to compare the NNT prevalence and the mortality rates from the existing surveillance system and active surveillance of health facility records in 7 selected health facilities from 2010 to 2014 in Katsina state, Nigeria and (b) to assess the associations between selected NNT risk factors, number of maternal tetanus toxoid injections, fr

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11

Sundstrom, Lars Eric. "An electrophysiological study of tetanus toxin-induced hippocampal epilepsy." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.256376.

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12

Deinhardt, Katrin. "The endocytic pathway of tetanus neurotoxin in motor neurons." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428573.

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13

Bercsenyi, K. "Nidogens are therapeutic targets for the prevention of tetanus." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464360/.

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Tetanus neurotoxin (TeNT) is among the most poisonous substances on Earth and a major cause of neonatal death in non-vaccinated areas. There are approximately 300,000 cases reported worldwide each year, and the mortality rate is between 10-20%. In this work, I identified an extracellular matrix protein receptor for TeNT at the neuromuscular junction (NMJ) and developed a peptide inhibitor, which prevents tetanic paralysis in vivo in mice. TeNT binds to the NMJ with an extremely high affinity, yet the nature of its receptor complex was poorly understood. I showed that the presence of nidogens (

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14

Colville, Caroline Anne. "The interaction of tetanus toxin with adrenal chromaffin cells." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/19641.

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Tetanus toxin exerts its primary biological effect by impairing the release of inhibitory neurotransmitters in the central nervous system; the mechanism of this blockade, however, remains unknown. Studies using adrenal medullary chromaffin cells, which are closely related to the toxin's target neurones but much more accessible to biochemical investigation, have the potential to provide information on various aspects of the intoxication process of tetanus. Nicotine-evoked (but not basal) secretion of catecholamines from intact chromaffin cells was inhibited by tetanus toxin in a dose-dependent

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15

Scott, Nathan. "Anti-tetanus toxin chelating recombinant antibodies by phage display." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4638.

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Chelating Recombinant Antibodies (CRAbs) are a form of high affinity tandem single chain antibody (scFv) with two component scFvs which target non‐overlapping epitopes on the same antigen molecule. The optimised inter‐scFv linker allows simultaneous engagement of the scFvs resulting in a synergistic improvement in affinity. High affinity is a desirable characteristic in therapeutic antibodies since it strongly correlates with improved potency. Building upon previous work, this thesis describes the development of a phage‐display based approach toward isolating CRAbs with both the optimal scFv p

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16

Pirazzini, Marco. "The entry of tetanus and botulinum neurotoxins into neurons." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423004.

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Tetanus and botulinum neurotoxins cause neuroparalysis by inhibiting neuroexocytosis. They are composed by two main chains: the 100 kDa heavy chain (H) mediates the neurospecific binding to target cells and chaperons the entry of the 50 kDa light chain (L). After binding on the plasma membrane, these neurotoxins enter into nerve terminals via endocytosis inside synaptic vesicles, as shown here for the first time by immuno-electron microscopy. The lumenal acidic pH induces a structural change of the neurotoxin molecule that becomes capable of translocating its L chain into the cytosol, via a tr

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17

Parton, Robert Glenn. "The binding and internalisation of tetanus toxin by neuronal tissue." Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/35122.

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18

Lawrence, Gary William. "Dissecting exocytosis from chromaffin cells with botulinum and tetanus toxins." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321807.

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19

Wheelock, Ana. "Determinants of adult influenza and tetanus vaccination in the UK." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/32270.

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Vaccination coverage in adults remains suboptimal. Health organisations have only recently begun to recognise the role of socio-psychological factors in vaccination decisions. These factors are particularly important, given that they are inherently amenable to policy and behaviour change. This thesis employs a mixed-methods approach to investigate the determinants of adult seasonal influenza and tetanus vaccination in the UK general adult population. It focuses on socio-psychological factors and draws upon health behaviour models, heuristics and biases and customer journey mapping theoretical

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20

Sweeney, Sean Thomas. "Targetted expression of tetanus toxin light chain in Drosophilia melanogaster." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627065.

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21

Ревенко, Г. О., В. В. Маврутенков, В. Ф. Дорошенко та ін. "Правець у невакцинованої дитини". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64660.

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Правець є актуальною проблемою національної системи охорони здоров’я, що пов’язано насамперед із низьким охопленням вакцинацією населення України.<br>Tetanus is a serious, potentially life-threatening infectious disease, occurrence of which is limited to post-vaccination immunity. This abstract clearly shows the clinical case of tetanus in unvaccinated 6-year-old child with favorable outcome. The disease duration was 64 days. This case is an objective indicator of the strength of epidemic process and system state immunization in the region.Targeting primary care physicians to provide

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22

Roßkopf, Ute. "Validierung der Wirksamkeitsprüfung für Clostridium tetani Impfstoffe ad usum veterinarium durch den direkten Nachweis von Tetanus-Antitoxin im Zieltier mittels ELISA." Giessen : VVB Laufersweiler, 2007. http://geb.uni-giessen.de/geb/volltexte/2007/4469/index.html.

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23

Andreu, Alice. "Tetanus toxin fragment C as a targeting moiety for gene delivery." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419230.

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24

Tamizifar, Hassan. "Enhancement of subunit influenza vaccine with diptheria - tetanus - pertussis (DTP) vaccination." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388739.

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25

Box, Michael Andrew. "Characterisation of the binding properties and gene delivery potential of tetanus toxin." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248341.

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26

Figueiredo, Dayse Maria De Magalhaes. "Characterization of tetanus toxin derivates suitable for the delivery of therapeutic proteins." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243965.

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27

Stelzmann, Mareike [Verfasser]. "Entwicklung eines Schnelltestsystems zum Nachweis von equinen Antikörpern (IgG) gegen Tetanus / Mareike Stelzmann." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025939182/34.

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28

Finnerty, Gerald Thomas. "Factors determining the transition to seizure in the tetanus toxin model of epilepsy." Thesis, Imperial College London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361453.

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29

Qazi, Omar. "Ganglioside binding, immunological and structural properties of the Hc fragment of tetanus toxin." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414409.

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30

Foss, Lucy Jane. "Effects of tetanus toxin on synaptic proteins in models of temporal lobe epilepsy." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4530/.

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Injection of tetanus toxin (TeNT), systemically or directly into the brain, has long been known to cause spastic paralysis or seizures respectively: thought to be due to disruption of inhibitory neurons and cleavage of vesicle associated membrane protein 2 (VAMP2). Here we investigate mechanisms involved in TeNT-induced chronic epilepsy in the first 16 days following injections in vivo and focally onto organotypic hippocampal slice cultures. Immunohistochemical analysis identified a spatial and temporal cleavage of both VAMP1 and VAMP2 progressing from day 2 post injection through to days 8 an

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31

Bohnert, Stephanie Anne. "Characterisation of the axonal transport dynamics of tetanus toxin in health and disease." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445322/.

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Tetanus toxin is internalised at the neuromuscular junction into vesicular carriers undergoing fast retrograde transport to the spinal cord. We determined the pH regulation of this compartment in living motor neurons using a chimera of the tetanus toxin binding fragment (TeNT He) and a pH-sensitive variant of the green fluorescent protein (ratiometric pHluorin). We have demonstrated that moving retrograde carriers display a narrow range of neutral pHs, which is kept constant during transport. Stationary TeNT Hc-positive organelles instead exhibit a wide spectrum of pHs, ranging from acidic to

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32

Fratelli, Fernando. "Avaliação da produção de toxina tetânica por \"Clostridium tetani\" cultivado por processos fermentativos descontínuo e descontínuo alimentado." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9134/tde-06122007-163303/.

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A toxina tetânica é uma proteína sintetizada pelo bacilo Clostridium tetani que após destoxificação através da ação do formol, continua apresentando propriedades antigênicas e imunogênicas, obtendo a denominação toxóide tetânico. A síntese dessa proteína ocorre quando esse bacilo encontra-se na sua forma vegetativa e em meio de cultura específico relativamente complexo contendo glicose e peptonas. O efeito simultâneo de diferentes níveis de glicose (Go) e N-Z Case TT® (NZo) como fontes de carbono e nitrogênio, respectivamente, na produção de toxina tetânica foi investigada nesta primeira parte

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33

O'Brien, Dawne, Ashley Santa-Cruz, and Amy Kennedy. "Assessing Adherence to the Tetanus, Diphtheria and Pertussis Vaccination Guidelines at a Federally Qualified Health Center Before and After a Clinical Pharmacist Intervention." The University of Arizona, 2014. http://hdl.handle.net/10150/614235.

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Class of 2014 Abstract<br>Specific Aims: Tetanus, diphtheria, and pertussis are diseases, which are preventable through proper vaccination. In spite of the availability these vaccines, however, there has recently been a surge in the number of pertussis cases in the United States. The objective of this study is to determine provider adherence to tetanus, diphtheria and pertussis guidelines set forth by the Advisory Committee on Immunization Practices in a primary care setting before and after a clinical pharmacist intervention.

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34

Roßkopf, Ute [Verfasser]. "Validierung der Wirksamkeitsprüfung für Clostridium-tetani-Impfstoffe ad usum veterinarium durch den direkten Nachweis von Tetanus-Antitoxin im Zieltier mittels ELISA / eingereicht von Ute Roßkopf." Giessen : VVB Laufersweiler, 2007. http://d-nb.info/988682664/34.

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35

Ventura, Nelson João Carneiro. "As neurotoxinas de clostridium sp.: os mecanismos de ação e a sua importância clínica." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5295.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>As neurotoxinas produzidas por espécies do género Clostridium, responsáveis pelo tétano e botulismo, são classificadas como potentes metaloproteases constituídas por três domínios funcionais dotados de diferentes funções: ligação neuroespecífica; internalização neuronal; translocação membranar; atividade proteolítica do complexo proteico soluble N-ethylmaleimide fusion attachment protein Receptor (SNARE). Os sete serotipos de neu

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36

Gingrich, Penny. "Susceptibility to tetanus and diphtheria in recently arrived adult immigrants and refugees to Montreal, Quebec." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86891.

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Background: Adult immigrants may have been under-immunized in their countries of origin. We estimated the seroprevalence and examined risk factors for susceptibility to diphtheria and tetanus.<br>Methods: 1480 newly-arrived adult immigrants were recruited in Montreal, 2002-2004. We collected socio-demographic information and vaccination history, and measured serum antibodies to tetanus and diphtheria by EIA to identify susceptibility, defined as ≤0.15 IU/ml and ≤0.10 IU/ml, respectively.<br>Results: 45% (95% CI, 42%-48%) of immigrants, mean age 31 +/- 8.6 years, lacked immunity to either tet

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37

Lalli, Giovanna. "The binding fragment of tetanus neurotoxin : a probe to study neuronal endocytosis and retrograde transport." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272379.

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38

Puumalainen, Taneli. "An eleven valent diphtheria and tetanus-conjugated pneumococcal vaccine immunogenicity and safety in Filipino infants." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/puumalainen/.

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39

Mastrodomenico, Jessica. "An Examination of the Socio-Demographic Characteristics Associated with Adult Vaccination Prevalence for Preventable Diseases in the United States." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/iph_theses/93.

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JESSICA MASTRODOMENICO An Examination of the Socio-Demographic Characteristics Associated with Adult Vaccination Prevalence for Preventable Diseases in the United States Background: An estimated 50,000 adults in the United States (U.S.) die each year from one of 10 vaccine preventable diseases. For those who survive vaccine preventable infections, health care costs and loss of income become more significant. While children in the U.S. aged 0-2 exhibit vaccine prevalence rates of almost 90%, some adult vaccine prevalence rates in the U.S. population are reported to be nearly 30-40% less than

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40

Heinrich, Daniela. "Untersuchungen über die antigenspezifische Immunität nach Diphtherie- und Tetanus-Schutzimpfung mit dem B-Zell-ELISPOT-Test." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=969653603.

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41

Aliprandini, Eduardo. "Obtenção de anticorpos monoclonais humanos antitetânicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-04122015-141425/.

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Anticorpos monoclonais (AcMos) para uso terapêutico correspondem a uma área importante na indústria de biofármacos, em especial os AcMos humanos, que apresentam menor probabilidade de elicitar imunogenicidade. O objetivo deste trabalho consistiu em obter AcMos humanos antitetânicos através da separação de linfócitos B produtores de anticorpos específicos utilizando o antígeno ou de plasmablastos. As células foram coletadas de doadores após vacinação e separadas por equipamento de cell sorter. As regiões variáveis dos anticorpos foram amplificadas e clonadas em vetores de expressão, que foram u

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42

Harrington, Noel P. "Suppression of murine splenic mononuclear cell response to mitogen by irradiation and tetanus toxoid: A study of possible mechanisms." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/6528.

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This study examines the possible mechanisms by which radiation and the bacterial toxin, Tetanus toxoid (TT), suppress the murine splenic mononuclear cell (SMNC) response to mitogen. This study demonstrates that the lymphocyte proliferation response of SMNC to the mitogenic lectin PHA can be suppressed by TT in a dose-dependant manner in vitro, without affecting the viability of the cells, in the anti-proliferative concentrations used (0.5-5 $\mu$g/ml). SMNC pre-incubated with TT could suppress the pHA blastogenic response of fresh autologous cells during co-incubation suggestion the involvemen

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43

Stefanovic, Helen. "Suppression of human peripheral blood mononuclear cell response to mitogen by tetanus toxoid. A study of the possible mechanisms." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7603.

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Previous studies have shown that certain antigens can down-regulate immune responses of human peripheral blood mononuclear cells (PBMC) both in vivo and in vitro. This study demonstrates that tetanus toxoid (TT), in a dose-dependent fashion, suppresses the induction of a blastogenic response of PBMC by phytohemagglutinin (PHA), monoclonal anti-CD3, and anti-CD4 antibody. Pokeweed mitogen (PWM)-induction of IgG and IgM is suppressed as well. The suppression is partially reversed by indomethacin and IL-2, but not by IL-1 or tumor necrosis factor (TNF-$\alpha$). PBMC pre-incubated with TT could s

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44

Foran, Patrick G. "Characterisation of the endoproteinase activities of tetanus and botulinum B neurotoxins and their use in the study of exocytosis." Thesis, Imperial College London, 1995. http://hdl.handle.net/10044/1/12020.

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45

Bartels, Britta Marlen [Verfasser], and Carsten [Akademischer Betreuer] Bokemeyer. "Erfassung von Tetanus-Toxoid- und Influenza-Nukleoprotein-spezifischen Antikörpern bei Patienten mit multiplem Myelom / Britta Marlen Bartels. Betreuer: Carsten Bokemeyer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1021499935/34.

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46

Yamamoto, Mutsuya. "Reversible suppression of glutamatergic neurotransmission of cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain." Kyoto University, 2003. http://hdl.handle.net/2433/148261.

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47

Hammarström, Viera. "B-cell immunity in patients with hematological malignancies and after stem cell transplantation : studies with special reference to tetanus and pneumococcal immunity /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980828hamm.

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48

Pereira, Martha Maria Mutti. "Eficácia da associação da vacina tríplice ao BCG." Universidade de São Paulo, 1986. http://www.teses.usp.br/teses/disponiveis/6/6135/tde-20122017-111313/.

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A eficácia da associação quádrupla (DPT + BCG) foi estudada através da proteção e comparação da soro conversão das vacinas, usando como adjuvante o hidróxido de alumínio e ou BCG. A potência da vacina pertussis foi avaliada pelo teste de proteção em camundongos e o BCG pelo teste de consumo de oxigênio e de vitalidade, sendo considerada satisfatória. Sendo os toxóides diftérico e tetânico considerados proteínas inertes e estáveis, suas potências não foram determinadas depois de associadas. Os níveis de anticorpos foram determinados para difteria e tétano pela reação imunoenzimática, para vacin

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49

Amaral, Ana de Carvalho Keil. "Clínica de ruminantes." Master's thesis, Universidade de Évora, 2015. http://hdl.handle.net/10174/17582.

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O presente relatório surge na sequência da realização do estágio curricular na coo-perativa Fomento Extremeño Ovino Sociedad Agraria de Transformación no âmbito do Mestrado Integrado em Medicina Veterinária na Universidade de Évora. Este relatório apresenta-se dividido em duas partes. Na primeira são descritas as atividades desenvolvi-das no controlo reprodutivo, profilaxia médica e clínica médica. A segunda parte é cons-tituída por uma revisão bibliográfica sobre o tétano em ovinos, patologia que tem especial importância nesta espécie devido aos procedimentos realizados no maneio ainda muito

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Usman, Hussain Raza. "Randomized controlled trial of low cost interventions to reduce childhood immunization dropouts in Pakistan." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/usman.pdf.

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