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Artykuły w czasopismach na temat "Therapeutic Responses Against Diseases"

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Das, Palamou, and Oishee Chakrabarti. "Mitochondrial DNA in innate immune responses against infectious diseases." Biochemical Society Transactions 48, no. 6 (2020): 2823–38. http://dx.doi.org/10.1042/bst20200687.

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Mitochondrial DNA (mtDNA) can initiate an innate immune response when mislocalized in a compartment other than the mitochondrial matrix. mtDNA plays significant roles in regulating mitochondrial dynamics as well as mitochondrial unfolded protein response (UPR). The mislocalized extra-mtDNA can elicit innate immune response via cGAS–STING (cyclic GMP-AMP synthase–stimulator of interferon genes) pathway, inducing the expression of the interferon-stimulated genes (ISGs). Also, cytosolic damaged mtDNA is cleared up by various pathways which are responsible for participating in the activation of in
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Schnitzer, Debra Jane, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.835625.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth
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Olajiga, Olayinka, Andrés F. Holguin-Rocha, Meagan Rippee-Brooks, Megan Eppler, Shanice L. Harris, and Berlin Londono-Renteria. "Vertebrate Responses against Arthropod Salivary Proteins and Their Therapeutic Potential." Vaccines 9, no. 4 (2021): 347. http://dx.doi.org/10.3390/vaccines9040347.

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The saliva of hematophagous arthropods contains a group of active proteins to counteract host responses against injury and to facilitate the success of a bloodmeal. These salivary proteins have significant impacts on modulating pathogen transmission, immunogenicity expression, the establishment of infection, and even disease severity. Recent studies have shown that several salivary proteins are immunogenic and antibodies against them may block infection, thereby suggesting potential vaccine candidates. Here, we discuss the most relevant salivary proteins currently studied for their therapeutic
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Bouche, Gauthier, Liese Vandeborne, Pan Pantziarka, and An M. T. Van Nuffel. "Repurposing infectious diseases vaccines against cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e14564-e14564. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e14564.

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e14564 Background: Vaccines used to prevent infection have long been known to stimulate immune responses to cancer as illustrated by the approval of the Bacillus Calmette–Guérin (BCG) vaccine to treat bladder cancer since the 1970s. The recent approval of immunotherapies has rejuvenated this research area with reports of anti-tumour responses with existing infectious diseases vaccines used as such, either alone or in combination with approved immune checkpoint inhibitors. This prompted us to review recent research activities using approved vaccines to treat cancer. Methods: PubMed and clinical
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Jung, Hi Eun, and Heung Kyu Lee. "Host Protective Immune Responses against Influenza A Virus Infection." Viruses 12, no. 5 (2020): 504. http://dx.doi.org/10.3390/v12050504.

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Influenza viruses cause infectious respiratory disease characterized by fever, myalgia, and congestion, ranging in severity from mild to life-threating. Although enormous efforts have aimed to prevent and treat influenza infections, seasonal and pandemic influenza outbreaks remain a major public health concern. This is largely because influenza viruses rapidly undergo genetic mutations that restrict the long-lasting efficacy of vaccine-induced immune responses and therapeutic regimens. In this review, we discuss the virological features of influenza A viruses and provide an overview of current
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Galindo-Izquierdo, María, and José Luis Pablos Alvarez. "Complement as a Therapeutic Target in Systemic Autoimmune Diseases." Cells 10, no. 1 (2021): 148. http://dx.doi.org/10.3390/cells10010148.

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The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune p
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D'Elia, Riccardo V., Kate Harrison, Petra C. Oyston, Roman A. Lukaszewski, and Graeme C. Clark. "Targeting the “Cytokine Storm” for Therapeutic Benefit." Clinical and Vaccine Immunology 20, no. 3 (2013): 319–27. http://dx.doi.org/10.1128/cvi.00636-12.

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ABSTRACTInflammation is the body's first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacteriumFrancisella tularensis, do trigger life-threatening “cytokine storms” in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that downregulating inflammatory immune responses may improve outcome. We rev
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Salters, Stephen P., Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.853132.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth
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Sohrab, Sayed Sartaj, Sherif Aly El-Kafrawy, Zeenat Mirza, Mohammad Amjad Kamal, and Esam Ibraheem Azhar. "Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus." Current Pharmaceutical Design 24, no. 1 (2018): 62–77. http://dx.doi.org/10.2174/1381612823666171109112307.

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Background: The MERS-CoV is a novel human coronavirus causing respiratory syndrome since April 2012. The replication of MERS-CoV is mediated by ORF 1ab and viral gene activity can be modulated by RNAi approach. The inhibition of virus replication has been documented in cell culture against multiple viruses by RNAi approach. Currently, very few siRNA against MERS-CoV have been computationally designed and published. Methods: In this review, we have discussed the computational designing and delivery of potential siRNAs. Potential siRNA can be designed to silence a desired gene by considering man
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Jung, Hi Eun, and Heung Kyu Lee. "Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection." Viruses 13, no. 11 (2021): 2132. http://dx.doi.org/10.3390/v13112132.

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The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It has affected every aspect of life and increased the burden on both healthcare and socioeconomic systems. Current studies have revealed that excessive inflammatory immune responses are responsible for the severity of COVID-19, which suggests that anti-inflammatory drugs may be promising therapeutic treatments. However, there are currently a limited number of approved therapeutics for COVID-19. Toll-like receptors (TLRs), which
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Rozprawy doktorskie na temat "Therapeutic Responses Against Diseases"

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Phalane, Khutso Gemina. "Evaluation of multiple cytokine levels to improve our understanding of protective immune responses against Tuberculosis and to develop novel diagnostic methods." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79848.

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Thesis (MScMedSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Important steps towards the global control of Tuberculosis include the improvement of diagnosis, the development of effective vaccines and the identification of correlates of protection/protective immunity to Mycobacterium tuberculosis. This study has of three objectives: 1. To validate the findings of a previous study that showed increased levels of IL-1β and decreased levels of IL-17 in children who are exposed to tuberculosis but remain uninfected compared to those who are exposed/infected and unexposed/uninfected. 2.
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Li, Yihang Kaltenboeck Bernhard. "Therapeutic vaccines against chlamydial diseases." Auburn, Ala., 2008. http://hdl.handle.net/10415/1417.

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Barakat, Farah Mukhlis. "Protective innate immune responses against Cryptosporidium parvum." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8733.

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Cryptosporidiosis is a common infectious diarrhoeal disease of mammalian livestock and humans worldwide. The etiological organisms responsible are intestinal apicomplexans of the genus Cryptosporidium, including C. parvum, that infect intestinal epithelial cells. Immunocompromised or malnourished hosts develop severe life-threatening disease. Immunological elimination of Cryptosporidium requires CD4+ T cells and IFN-γ. Nevertheless, studies have shown innate immune responses have a significant protective role. Importantly, in T cell-deficient mice, IFN-γ is important for control of C. parvum i
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Yenilmez, Batuhan O. "DEVELOPMENT OF AN RNAi THERAPEUTIC STRATEGY AGAINST NON-ALCOHOLIC STEATOHEPATITIS (NASH)." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1158.

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Nonalcoholic steatohepatitis (NASH) is a severe liver disorder characterized by triglyceride accumulation, severe inflammation, and fibrosis. With the recent increase in prevalence, NASH is now the leading cause of liver transplantation, with no approved therapeutics available. Despite years of research, the exact molecular mechanism of NASH progression is not well understood, but fat accumulation is believed to be the primary driver of the disease. Therefore, diacylglycerol O-acyltransferase 2 (DGAT2), a key enzyme in triglyceride synthesis, has been explored as a NASH target. RNAi-based ther
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Antrobus, Richard. "Characterising immune responses to viral vectored vaccines against influenza and hepatitis C." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a3efad5e-d619-4641-8c05-2d4e336a10dc.

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For both influenza viruses and hepatitis C viruses, T cell responses to conserved antigens are one strategy for the human host to control the spread of infection. Such T cell responses can be generated with the use of viral vectored vaccines. Initially I show that the viral vectored vaccine MVA-NP+M1 can boost memory T cell responses to influenza A virus in adults aged over 50 years old. However within this group, MVA-NP+M1 had reduced immunogenicity in adults who were aged over 70 years old. The influenza virus-specific T cell responses comprised both CD4 and CD8 T cells, and were capable of
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Ye, Xingshen, and 叶星沈. "Studies on effects of coptis extract and berberine against carbon tetrachloride-induced liver damage in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38755208.

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Jayatunga, Dona Pamoda Wajirapanie. "Investigation of selected nutraceuticals to protect against mitochondrial dysfunction: Potential therapeutic role in Alzheimer’s disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2020. https://ro.ecu.edu.au/theses/2368.

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Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that affects approximately 60-80% of all clinically diagnosed dementia cases worldwide. It is the second major cause of death in Australia. The progressive nature of the disease is characterized by cognitive deficits that worsen over time, usually leading to death within about a decade from their first manifestation. The AD brain is classically characterized by extracellular deposition of amyloid-β (Aβ) protein aggregates, as senile plaques, and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated fo
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Xie, Lixia. "Effects of salvianolic acid B against apoptosis and adhesion molecules expression in the vascular endothelial cells." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1082.

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Kelly, Christabel. "Novel adenoviral vectored vaccines and the implications of viral diversity in therapeutic strategies against Hepatitis C Virus infection." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:8991c349-7096-4643-ae6a-2e36902c8056.

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Hepatitis C virus (HCV) is a major global pathogen estimated to infect over 170 million people worldwide. A recent study has shown that vaccination with adenoviral vectors, based on rare human and simian serotypes encoding the non-structural (NS) proteins of HCV, induces highly potent, multi-specific and durable T cell responses in healthy human volunteers. In this thesis I assess the safety and immunogenicity of these vaccines (ChAd3–NSmut and Ad6-NSmut), for the first time in HCV infected patients. This work also explores whether vaccine-induced T cell responses target in vivo circulating HC
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Zuber, Chantal. "Antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools for the treatment of prion diseases and cancer." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-88001.

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Książki na temat "Therapeutic Responses Against Diseases"

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Zahid Balouch, Fahmida Khatoon, ed. Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4.

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Patil, Vaishali Manikrao, Dileep Kumar, and NEERAJ MASAND. Molecular Targets and Therapeutic Interventions Against Neurodegenerative Diseases. CRC Press, 2025. https://doi.org/10.1201/9781003506317.

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1915-, Gruenberg Ernest M., Lewis Carol 1931-, and Goldston Stephen E, eds. Vaccinating against brain syndromes: The campaign against measles and rubella. Oxford University Press, 1986.

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Maes, Dominiek, Marina Sibila, and Maria Pieters, eds. Mycoplasmas in swine. CABI, 2021. http://dx.doi.org/10.1079/9781789249941.0000.

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Abstract This book contains 14 chapters that discuss the genetics, epidemiology, prevalence, pathogenesis, clinical signs, diagnosis, treatment, prevention and control of Mycoplasma infections in pigs. Chapter 1 discusses the phylogenetics and classification of Mycoplasma species in pigs; Chapter 2 describes the genomic diversity and antigenic variation of Mycoplasma hyopneumoniae strains; Chapter 3 discusses the pathogenesis, virulence factor and pathogenicity of Mycoplasma hyopneumoniae; Chapter 4 discusses the molecular epidemiology, risk factors, transmission and prevalence of Mycoplasma h
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Balouch, Fahmida Khatoon Zahid. Therapeutic Proteins Against Human Diseases. Springer Singapore Pte. Limited, 2022.

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Therapeutic Proteins Against Human Diseases. Springer, 2023.

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Eljaafari, Assia, and Pierre Miossec. Cellular side of acquired immunity (T cells). Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0049.

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The adaptive T-cell response represents the most sophisticated component of the immune response. Foreign invaders are recognized first by cells of the innate immune system. This leads to a rapid and non-specific inflammatory response, followed by induction of the adaptive and specific immune response. Different adaptive responses can be promoted, depending on the predominant effector cells that are involved, which themselves depend on the microbial/antigen stimuli. As examples, Th1 cells contribute to cell-mediated immunity against intracellular pathogens, Th2 cells protect against parasites,
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Sakkiah, Sugunadevi, Keun Woo Lee, Chandrabose Selvaraj, and Brijesh Kumar Singh, eds. Novel Therapeutic Interventions Against Infectious Diseases: COVID-19. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-846-4.

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Malheiro, Adriana, David Courtin, Eduardo Antonio Donadi, and Rajendranath Ramasawmy, eds. The Role of Gene Polymorphism in Modulating the Immune Responses against Tropical Infectious Diseases. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-382-0.

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Kuete, Victor. Medicinal Spices and Vegetables from Africa: Therapeutic Potential Against Metabolic, Inflammatory, Infectious and Systemic Diseases. Elsevier Science & Technology Books, 2017.

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Części książek na temat "Therapeutic Responses Against Diseases"

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Jain, Ananya, and Shilpa Sharma. "Nanotechnology in COVID-19 Vaccines." In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022). Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_3.

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AbstractNanotechnology has been proposed in vaccine development as carriers and adjuvants time and again but received limited recognition before the development of vaccines for the COVID-19 pandemic. Nanotechnology has played a pivotal role in the triumph of the vaccines for the current pandemic caused by the SARS-CoV-2 virus. The first vaccine got approved within a year of the earliest reported case of the novel coronavirus. Presently, more than 35 vaccines are approved in at least one country, 10 out of which are sanctioned for emergency use by the WHO. The key categories include peptide vac
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Leemon, Nikhila, S. S. Raga, V. S. Soumya, and Sreejith Parameswara Panicker. "Therapeutic Peptides in Skin and Hair Disorders." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_10.

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Ramakrishnan, V., M. Vajagathali, and B. K. Iyshwarya. "Therapeutic Protein Against Autoimmune Disorders: Intracellular and Extracellular Properties." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_4.

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Bari, Ahamed Basha Abdul, and Prince Johnson Samuel. "Therapeutic Proteins Used in Human Pancreatic Disease." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_8.

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Das, Alakesh, Dikshita Deka, Antara Banerjee, and Surajit Pathak. "Therapeutic Role of Soybean-Derived Lunasin Peptide in Colon Cancer Treatment: A Recent Updates from Literature." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_9.

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Molehin, Olorunfemi R., Alaba A. Adebayo, Adeniyi S. Ohunayo, Ajibade O. Oyeyemi, and Jacinta O. Okonkwo. "Prions as Therapeutic Proteins and their Prospect as Drug Delivery Agent." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_5.

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Anuja, A. V., Sarojini K. Rajinikanth, Lalitha Shanmugam, and Prince Johnson Samuel. "Interferons." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_2.

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Rajinikanth, Sarojini K., Lalitha Shanmugam, A. V. Anuja, and Prince Johnson Samuel. "Interleukin-2." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_6.

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Mookkandi, Sudhan, Jency Roshni, Janakiraman Velayudam, Mahema Sivakumar, and Shiek Fareeth Ahmed. "Bioinformatics Resources, Tools, and Strategies in Designing Therapeutic Proteins." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_7.

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Subbaraj, Gowtham Kumar, Sangavi Jeyachandran, Priyanka Ganapathy, et al. "Proteins Drug Targeting and Its Therapeutics." In Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4_1.

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Streszczenia konferencji na temat "Therapeutic Responses Against Diseases"

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Moskalets, O. V. "Anti-rituximab antibodies in refractory / relapsing cases of chronic lymphocytic leukemia." In General question of world science. L-Journal, 2020. http://dx.doi.org/10.18411/gq-30-11-2020-02.

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Rituximab, a chimeric monoclonal antibody targeted against the pan-B-cell marker CD20, is widley used for treatment of lymphomas, rheumatologic diseases and other – 8 – General question of world science disorders. It is known that many monoclonal antibodies such as rituximab can elicit anti-drug antibodies, which may interfere with therapeutic response. The aim of this study was to investigate the incidence of antibodies to rituximab in patients with chronic lymphocytic leukemia. Serum concentrations of anti-rituximab antibodies was determined in blood serum of patients with B-chronic lymphocy
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JAWAD, Israa, Adian Abd Alrazak DAKL, and Hussein Jabar JASIM. "CHARACTERIZATION, MECHANISM OF ACTION, SOURCES TYPES AND USES OF THE ANTIMICROBIAL PEPTIDES IN DOMESTIC ANIMALS, REVIEW." In VII. INTERNATIONAL SCIENTIFIC CONGRESSOF PURE,APPLIEDANDTECHNOLOGICAL SCIENCES. Rimar Academy, 2023. http://dx.doi.org/10.47832/minarcongress7-13.

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This review aimed to identify the general characteristics of , mechanism of action, types and uses of antimicrobial peptides in animals, antimicrobial peptides were lass of small peptides that widely exist naturally, they varied greatly in structure, composition are found in the animal's species, and were standard structural features, twenty to sixty residue long, cationic and amphipathic peptides, have a positive charge that interacted with negatively charged molecules on the bacterial cell surfaces, a have an expansive field of inhibitory effects and were made as the first line of protection
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Zhuang, Ran, Jiawei Tian, Apostolos Tassiopoulos, Chandramouli Sadasivan, Xianfeng David Gu, and Shikui Chen. "Designing Programmable Ferromagnetic Soft Metastructures for Minimally Invasive Endovascular Therapy." In ASME 2023 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/detc2023-116342.

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Abstract Minimally invasive endovascular therapy (MIET) is an innovative technique that utilizes percutaneous access and transcatheter implantation of medical devices to treat vascular diseases. However, conventional devices often face limitations such as incomplete or suboptimal treatment, leading to issues like recanalization in brain aneurysms, endoleaks in aortic aneurysms, and paravalvular leaks in cardiac valves. In this study, we introduce a new metastructure design for MIET employing re-entrant honeycomb structures with negative Poisson’s ratio (NPR), which are initially designed throu
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Cananéa Neto, Simeão Fernandes Cardoso, Brendo Bezerra Bevenuto, Iury Hélder Santos Dantas, Fernando de Paiva Melo Neto, and Bianca Etelvina Santos de Oliveira. "The importance of nonpharmacological strategies and the management of depression in patients with multiple sclerosis: an integrative review." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.468.

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Introduction: Multiple sclerosis (MS) is a chronic and demyelinating disease of the central nervous system. Among the symptoms that patients with MS may develop, depression stands out, which is associated with an important decline in quality of life. The presence of this symptom is associated with a worse prognosis. There is much support in the literature of the positive role that non-pharmacological measures play in controlling depression in patients with MS, with a range of options for the patient to choose from. Objectives: To analyze studies that deal with non-pharmacological therapeutic s
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Cubillos-Ruiz, Juan R. "Abstract TMIM-068: TARGETING ER STRESS RESPONSES TO UNLEASH THERAPEUTIC IMMUNITY AGAINST OVARIAN CANCER." In Abstracts: 12th Biennial Ovarian Cancer Research Symposium; September 13-15, 2018; Seattle, Washington. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1557-3265.ovcasymp18-tmim-068.

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Leca, Julie. "Abstract B170: Therapeutic implications of altered epigenetics and DNA damage responses in IDH2-mutated hematologic diseases." In Abstracts: Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 30 - October 3, 2018; New York, NY. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr18-b170.

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M, Nivya R., and Amitha Joy. "Computer Aided Discovery of Phyto Derived Calcineurin Inhibitors as Potential Therapeutic Candidates Against Neurodegenerative Diseases." In 2023 IEEE 11th Region 10 Humanitarian Technology Conference (R10-HTC). IEEE, 2023. http://dx.doi.org/10.1109/r10-htc57504.2023.10461744.

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Muromtsev, A. B., A. Y. Efremov, S. V. Engashev, E. S. Engasheva, and Y. K. Antropov. "STUDY ON THE THERAPEUTIC EFFICACY OF AN ORAL IVERMECTIN AND PRAZIQUANTEL PREPARATION AGAINST SOME PARASITIC DISEASES OF CATTLE." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. VNIIP – FSC VIEV, 2025. https://doi.org/10.31016/978-5-6053355-1-1.2025.26.218-222.

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A study on the therapeutic efficacy of an ivermectin and praziquantel combination against parasitic diseases in cattle established that this combination exhibits high activity against both endoparasites and ectoparasites. When administered orally with feed at a dose of 1 mL/20 kg of body weight, the drug provided 90–92% extense-effectiveness and 95–100% intense-effectiveness. It demonstrated excellent results against monieziasis, dictyocaulosis, strongyloidiasis, and arachnoentomosis, including ixodidosis, sarcoptic mange, chorioptosis, boviculosis, and siphunculatosis. Clinical examinations a
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Sieiro Santos, C., C. Moriano Morales, and E. Díez Alvarez. "PO.8.169 Immune responses to mrna vaccines against SARS-COV-2 in patients with immune-mediated inflammatory rheumatic diseases." In 13th European Lupus Meeting, Stockholm (October 5–8, 2022). Lupus Foundation of America, 2022. http://dx.doi.org/10.1136/lupus-2022-elm2022.188.

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Ryan, David T., Jingzhe Hu, Byron L. Long, and Amina A. Qutub. "Predicting Endothelial Cell Phenotypes in Angiogenesis." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93124.

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Controlling endogenous angiogenesis, or the formation of new capillaries, is a potential therapeutic strategy for numerous diseases including cancer, stroke and cardiovascular disease (1–4). These efforts have been met with mixed success in the clinic, partly due to an inadequate understanding, and thus control, of the mechanisms that influence the endothelial cells that form capillaries (1, 3). In order to control angiogenesis in an effort to improve treatment responses, quantitative information about endothelial cell behavior must be used to build accurate models of vascular network formatio
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Raporty organizacyjne na temat "Therapeutic Responses Against Diseases"

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Lillehoj, Hyun, Dan Heller, and Mark Jenkins. Cellular and molecular identification of Eimeria Acervulina Merozoite Antigens eliciting protective immunity. United States Department of Agriculture, 1992. http://dx.doi.org/10.32747/1992.7561056.bard.

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Coccidiosis, ubiquitous diseases of poultry, seriously impair the growth and feed utilization of livestock and poultry. Coccidiosis causes over $600 million annual losses world-wide and no vaccine is currently available. The goal of this study was to investigate the cellular and molecular mechanisms controlling protective immune responses to coccidia parasites in order to develop immunological control strategy against coccidiosis. The major findings of this study were: 1) cell-mediated immunity plays a major role in protection against coccidiosis, 2) when different genetic lines showing differ
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Caparini, Marina. Multilateral Peace Operations and the Challenges of Epidemics and Pandemics. Stockholm International Peace Research Institute, 2022. http://dx.doi.org/10.55163/awyk9746.

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This paper provides a broad overview of how multilateral peace operations have responded to cholera and Ebola epidemics and the HIV/ AIDS and Covid-19 pandemics over the past 20 years. Such public health crises can be especially lethal in fragile and conflict-affected areas. Peace operations possess resources and capacities that enable them to contribute in varying ways to state and humanitarian responses. Multilateral peace operations have acted to protect the health of peacekeepers and to prevent peacekeepers from spreading infectious diseases. They have also directly provided security to he
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Baszler, Timothy, Igor Savitsky, Christopher Davies, Lauren Staska, and Varda Shkap. Identification of bovine Neospora caninum cytotoxic T-lymphocyte epitopes for development of peptide-based vaccine. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7695592.bard.

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The goal of the one-year feasibility study was to identify specific cytotoxic T-lymphocyte (CTL) epitopes to Neosporacaninum in the natural bovine host in order to make progress toward developing an effective peptide-based vaccine against bovine neosporosis. We tested the hypothesis that: N. caninum SRS2 peptides contain immunogenicCTLepitope clusters cross-presented by multiple bovine MHC-I and MHC-IIhaplotypes. The specific objectives were: (1) Map bovine CTLepitopes of N. caninum NcSRS-2 and identify consensus MHC-I and class-II binding motifs; and (2) Determine if subunit immunization with
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99mTc SPECT-CT, Consensus QIBA Profile. Chair Yuni Dewaraja and Robert Miyaoka. Radiological Society of North America (RSNA)/Quantitative Imaging Biomarkers Alliance (QIBA), 2019. https://doi.org/10.1148/qiba/20191021.

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The quantification of 99mTc labeled biomarkers can add unique value in many different settings, ranging from clinical trials of investigation new drugs to the treatment of individual patients with marketed therapeutics. For example, goals of precision medicine include using companion radiopharmaceutical diagnostics as just-in-time, predictive biomarkers for selecting patients to receive targeted treatments, customizing doses of internally administered radiotherapeutics, and assessing responses to treatment. This Profile describes quantitative outcome measures that represent proxies of target c
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Cohen, Roni, Kevin Crosby, Menahem Edelstein, et al. Grafting as a strategy for disease and stress management in muskmelon production. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7613874.bard.

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The overall objective of this research was to elucidate the horticultural, pathological, physiological and molecular factors impacting melon varieties (scion) grafted onto M. cannonballus resistant melon and squash rootstocks. Specific objectives were- to compare the performance of resistant melon germplasm (grafted and non-grafted) when exposed to M. cannoballus in the Lower Rio Grande valley and the Wintergarden, Texas, and in the Arava valley, Israel; to address inter-species relationships between a Monosporascus resistant melon rootstock and susceptible melon scions in terms of fruit-set,
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Sessa, Guido, and Gregory Martin. Role of GRAS Transcription Factors in Tomato Disease Resistance and Basal Defense. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696520.bard.

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The research problem: Bacterial spot and bacterial speck diseases of tomato are causedby strains of Xanthomonas campestris pv. vesicatoria (Xcv) and Pseudomonas syringae pv.tomato (Pst), respectively. These bacteria colonize aerial parts of the plant and causesignificant losses in tomato production worldwide. Protection against Xcv and Pst bycultural practices or chemical control has been unsuccessful and there are only limitedsources of genetic resistance to these pathogens. In previous research supported in part byBARD IS-3237-01, we extensively characterized changes in tomato gene expressio
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