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Zahid Balouch, Fahmida Khatoon, ed. Therapeutic Proteins Against Human Diseases. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7897-4.

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Patil, Vaishali Manikrao, Dileep Kumar, and NEERAJ MASAND. Molecular Targets and Therapeutic Interventions Against Neurodegenerative Diseases. CRC Press, 2025. https://doi.org/10.1201/9781003506317.

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1915-, Gruenberg Ernest M., Lewis Carol 1931-, and Goldston Stephen E, eds. Vaccinating against brain syndromes: The campaign against measles and rubella. Oxford University Press, 1986.

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Maes, Dominiek, Marina Sibila, and Maria Pieters, eds. Mycoplasmas in swine. CABI, 2021. http://dx.doi.org/10.1079/9781789249941.0000.

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Abstract This book contains 14 chapters that discuss the genetics, epidemiology, prevalence, pathogenesis, clinical signs, diagnosis, treatment, prevention and control of Mycoplasma infections in pigs. Chapter 1 discusses the phylogenetics and classification of Mycoplasma species in pigs; Chapter 2 describes the genomic diversity and antigenic variation of Mycoplasma hyopneumoniae strains; Chapter 3 discusses the pathogenesis, virulence factor and pathogenicity of Mycoplasma hyopneumoniae; Chapter 4 discusses the molecular epidemiology, risk factors, transmission and prevalence of Mycoplasma h
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Balouch, Fahmida Khatoon Zahid. Therapeutic Proteins Against Human Diseases. Springer Singapore Pte. Limited, 2022.

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Therapeutic Proteins Against Human Diseases. Springer, 2023.

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Eljaafari, Assia, and Pierre Miossec. Cellular side of acquired immunity (T cells). Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0049.

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The adaptive T-cell response represents the most sophisticated component of the immune response. Foreign invaders are recognized first by cells of the innate immune system. This leads to a rapid and non-specific inflammatory response, followed by induction of the adaptive and specific immune response. Different adaptive responses can be promoted, depending on the predominant effector cells that are involved, which themselves depend on the microbial/antigen stimuli. As examples, Th1 cells contribute to cell-mediated immunity against intracellular pathogens, Th2 cells protect against parasites,
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Sakkiah, Sugunadevi, Keun Woo Lee, Chandrabose Selvaraj, and Brijesh Kumar Singh, eds. Novel Therapeutic Interventions Against Infectious Diseases: COVID-19. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-846-4.

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Malheiro, Adriana, David Courtin, Eduardo Antonio Donadi, and Rajendranath Ramasawmy, eds. The Role of Gene Polymorphism in Modulating the Immune Responses against Tropical Infectious Diseases. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-382-0.

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Kuete, Victor. Medicinal Spices and Vegetables from Africa: Therapeutic Potential Against Metabolic, Inflammatory, Infectious and Systemic Diseases. Elsevier Science & Technology Books, 2017.

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Kuete, Victor. Medicinal Spices and Vegetables from Africa: Therapeutic Potential Against Metabolic, Inflammatory, Infectious and Systemic Diseases. Elsevier Science & Technology Books, 2017.

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Alharbi, Yousef, Manish S. Patankar, and Rebecca J. Whelan. Antibody-Based Therapy for Ovarian Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0006.

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With their role in connecting disease-associated antigens to the cellular immune response, antibodies hold considerable promise as therapeutic agents. This chapter discusses three classes of therapeutic antibodies that have been developed for use in ovarian cancer therapy. The first includes antibodies selected against tumor-associated antigens such as MUC16/CA125, mesothelin, epithelial cell adhesion molecule, and folate receptor α‎. Antibodies in the second class target proteins such as CTLA-4 and PD1 that act as immune response checkpoint receptors. The third class of antibodies target secr
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van der Vlag, Johan, and Jo H. M. Berden. The patient with systemic lupus erythematosus. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0161.

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations. The hallmark of SLE is the presence of antibodies against nuclear constituents, such as double-stranded (ds)DNA, histones, and nucleosomes. Local deposition of antinuclear antibodies in complex with nuclear autoantigens induces serious inflammatory conditions that can affect several tissues and organs, including the kidney.The levels of antinucleosome and anti-dsDNA antibodies seem to correlate with glomerulonephritis and these autoantibodies can often be detected years before the patient
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Vaccinating Against Brain Syndromes: The Campaign Against Measles and Rubella (Monographs in Epidemiology and Biostatistics, Vol 9). Oxford University Press, USA, 1986.

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Guideline for the Treatment of Leishmaniasis in the Americas. Second Edition. Pan American Health Organization, 2022. http://dx.doi.org/10.37774/9789275125038.

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Leishmaniasis is a neglected infectious disease of great importance in the Region of the Americas because of its prevalence, wide geographical distribution, morbidity and mortality. Several species of Leishmania can cause disease, and the resulting presentations differ in their clinical manifestations, diagnostic signs, severity, and treatment responses. The three main forms of leishmaniasis disease are: cutaneous, mucosal or visceral, of which cutaneous leishmaniasis is the most common. Visceral leishmaniasis (caused by L. infantum) is the most severe form and can cause death in up to 90% of
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Land, Walter Gottlieb. Damage-Associated Molecular Patterns in Human Diseases Vol. 1 and Vol. 2: Injury-Induced Innate Immune Responses and Danger Signals As Diagnostics, Prognostics, and Therapeutic Targets. Springer International Publishing AG, 2020.

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Santos, Dilvani Oliveira, and Paulo Renato Zuquim Antas, eds. Mitochondrial DNA and the Immuno-inflammatory Response: New Frontiers to Control Specific Microbial Diseases. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150516981220301.

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Mitochondria are multifunctional organelles that actively participate in the immune-inflammatory response in various pathologies. This volume updates readers on knowledge about mitochondria function. The editors have compiled six chapters about inflammation in its broadest sense, with contributions from active groups of cell biologists, infectologists and pathologists. The chapters in this volume focus on research related to five notable diseases: (1) two diseases (one bacterial and one viral) in which the exacerbation of the inflammatory response can lead to neuropathies: leprosy (one of the
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Westlund, Andrea C. Answerability without Blame? Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190609610.003.0011.

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Widely derided by popular psychologists as a destructive response, blame has many defenders among contemporary philosophers. The chapter pushes against their defenses of blame by distinguishing between blame as a reactive attitude and blaming as a speech act, arguing that some disagreement over blame’s value can be explained by the fact that blaming, as a speech act, takes several different forms. Critiques of blame properly target judgmental or strongly verdictive blaming, which treats the wrongdoer as deserving of the blamer’s hostile reactions. This tends to foreclose engagement in further
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Wiersinga, W. Joost, and Tom van der Poll. The host response to infection in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0303.

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Infection continues to be a leading cause of intensive care unit death. The host response to infection can be seen as a pattern recognition receptor (PRR)-mediated dysregulation of the immune system following pathogen invasion in which a careful balance between inflammatory and anti-inflammatory responses is vital. A measured and rapid response to microbial invasion is essential to health. The same immunological and coagulation systems that protect against localized infection can act to our disadvantage when these systems are activated systemically during generalized microbial infection. Toll-
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Karpova, Nina N. Pharmacological Adjuncts and Evidence-Supported Treatments for Trauma. Edited by Sara Maltzman. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199739134.013.32.

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A large proportion of humans experienced a traumatic event in their lifetime, with more than 10% developing posttraumatic stress disorder (PTSD), panic disorder, phobias, and other fear/anxiety disorders. The neural circuitry of fear responses is highly conserved in humans as well as rodents, and this allows for translational research using animal models of fear. Fear/anxiety disorders in humans are most efficiently treated by exposure-based psychotherapy (i.e., cognitive behavioral therapy; CBT), the main aspects of which are closely modeled by extinction training in Pavlovian fear conditioni
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Geri, Guillaume, and Jean-Paul Mira. Host–pathogen interactions in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0306.

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Infection by a pathogenic micro-organism triggers a coordinated activation of both innate and adaptive immune responses. The innate immune response quickly triggers an antimicrobial response that will initiate development of a pathogen-specific, long-lasting adaptive immune response. Accurate recognition of microbial-associated molecular patterns by pattern-recognition receptors (PRRs) is the cornerstone of this immediate response. Most studied PRRs are Toll-like receptors (TLRs) and their kinase signalling cascades that activate nuclear transcription factors, and induce gene expression and cy
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Ackland, Gareth L. Neural and endocrine function in the immune response to critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0310.

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The neurohormonal physiological response to various stressors is pivotal for maintaining homeostasis. However, the advent of modern critical care has distorted evolutionary biology by generating the entirely new (patho)physiological entity of critical illness. By extending the biological features of the ‘fight or flight’ response beyond the acute phase, distinct neurohormonal, and immune profiles have become increasingly apparent. Both direct and off-target effects of neurohormonal control on immune function are implicated in the disruption of bidirectional links between neurohormones and immu
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van Assen, Sander, and Marc Bijl. Vaccination in immunocompromised adults. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0094.

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This chapter addresses all important questions regarding vaccination of patients with autoimmune inflammatory rheumatic diseases (AIIRD). First, the incidence of vaccine-preventable infections in these patients is discussed. Pulmonary infections, including influenza and pneumococcal infection, occur more often in AIIRD patients; herpes zoster and human papillomavirus are also more frequent. The efficacy of vaccination for all European registered vaccines is discussed. Treatment with disease-modifying anti-rheumatic drugs (DMARDs) and biologicals (in particular TNFα‎-blocking agents) do not ham
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Heijstek, Marloes, Mario Abinun, and Nico Wulffraat. Vaccination in immunocompromised children. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0095.

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Can immunocompromised children be safely and effectively vaccinated? This chapter discusses the recommendations from the European League Against Rheumatism (EULAR) for the immunization of immunocompromised patients. Patients with rheumatic or autoinflammatory diseases treated with high-dose glucocorticoids, high-dose disease-modifying anti-rheumatic drugs (DMARDs), or biologicals are considered immunocompromised. Safe and effective vaccination is crucial in these patients, given their increased risk of infection. Safe vaccination implies that vaccination has no effect on disease activity and h
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Heijstek, Marloes, Mario Abinun, and Nico Wulffraat. Vaccination in immunocompromised children. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0095_update_003.

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Can immunocompromised children be safely and effectively vaccinated? This chapter discusses the recommendations from the European League Against Rheumatism (EULAR) for the immunization of immunocompromised patients. Patients with rheumatic or autoinflammatory diseases treated with high-dose glucocorticoids, high-dose disease-modifying antirheumatic drugs (DMARDs), or biologicals are considered immunocompromised. Safe and effective vaccination is crucial in these patients, given their increased risk of infection. Safe vaccination implies that vaccination has no effect on disease activity and ha
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Klenerman, Paul. The Immune System: A Very Short Introduction. Oxford University Press, 2017. http://dx.doi.org/10.1093/actrade/9780198753902.001.0001.

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The Immune System: A Very Short Introduction describes the immune system and how it works in health and disease. It focuses on the human immune system, considering how it evolved, and the basic rules that govern its behaviour. The immune system comprises a series of organs, cells, and chemical messengers that work together as a team to provide defence against infection. These components are discussed along with the critical signals that trigger them and how they exert their protective effects, including innate and adaptive responses. The consequences of too little immunity (immunodeficiency),
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Chua, Lynette J., and Jack Jin Gary Lee, eds. Contagion, Technology, and Law at the Limits. Hart Publishing, 2024. http://dx.doi.org/10.5040/9781509970735.

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This open access book explores law, politics, and inequality in fights against infectious diseases. Guided by a theoretical framework called “governing through contagion”, the studies in this book analyse how past and present governments have tried to combat contagious diseases, such as the bubonic plague, cholera, HIV/AIDS, and COVID-19. They examine how these governments used law and other technologies, including waste management, mask-wearing, quarantine stations, house inspections, and the burning of entire neighbourhoods, to achieve their aims of protecting populations and ensuring produc
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Karaman, Sinem, Aleksanteri Aspelund, Michael Detmar, and Kari Alitalo. The lymphatic system. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0009.

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The lymphatic vascular system is an integral component of the circulatory system; it forms a one-way conduit that transports tissue interstitial components back to the venous circulation through lymph nodes. Lymphatic vessels extend to most tissues and contribute to the regulation of interstitial fluid homeostasis, trafficking of immune cells, and absorption of dietary fats from the gut. Developmentally, lymphatic vessels originate from embryonic veins and specialized angioblasts. A number of molecules have been identified in the commitment of endothelial cells to the lymphatic lineage, and th
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Boyle, Eric W. Quack Medicine. ABC-CLIO, LLC, 2013. http://dx.doi.org/10.5040/9798216003595.

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This timely volume illustrates how and why the fight against quackery in modern America has largely failed, laying the blame on an unlikely confluence of scientific advances, regulatory reforms, changes in the medical profession, and the politics of consumption. Throughout the 20th century, anti-quackery crusaders investigated, exposed, and attempted to regulate allegedly fraudulent therapeutic approaches to health and healing under the banner of consumer protection and a commitment to medical science. Quack Medicine: A History of Combating Health Fraud in Twentieth-Century America reveals how
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Reddy, Ugan, and Nicholas Hirsch. Diagnosis, assessment, and management of myasthenia gravis and paramyasthenic syndromes. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0244.

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Diseases that affect the neuromuscular junction (NMJ) interfere with normal nerve transmission and cause weakness of voluntary muscles. The two most commonly encountered are acquired myasthenia gravis (MG) and the Lambert–Eaton myasthenic syndrome (LEMS). Acquired MG is an autoimmune disease in which antibodies are directed towards receptors at the NMJ. In 85% of patients, IgG antibodies against the postsynaptic acetylcholine receptor (AChR) are found (seropositive MG). The thymus gland appears to be involved in the production of these which cause an increase rate of degradation of AChR result
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Slack, Jonathan. Stem Cells: A Very Short Introduction. 2nd ed. Oxford University Press, 2021. http://dx.doi.org/10.1093/actrade/9780198869290.001.0001.

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Stem Cells: A Very Short Introduction explains what stem cells are, why they are important, what scientists do with them, and how they might be used in the future. It tackles recent scientific and clinical developments surrounding stem cells, exploring their enormous therapeutic potential to treat diseases, such as macular degeneration, diabetes, and Parkinson’s disease. It also provides cautions against false claims from some clinics offering treatments and draws out lessons for the development of new stem therapies in the future. The VSI deals with the science and medicine of stem cells rath
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Mikhaylova, Yu V. Genetic Technologies. Central Research Institute for Epidemiology, 2020. http://dx.doi.org/10.36233/978-5-6045286-3-1.

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The book «Genetic Technologies» covers a wide range of topics in the field of genetic technologies related to genome editing, and summarizes the latest scientific data on the use of programmable nucleases in various fields related to genome modification. The monography «Genetic Technologies» will be interesting and useful for students of biological and medical universities, graduate students, young scientists, researchers, healthcare professionals and will help them to systematize knowledge in the rapidly developing field of genetic technologies and genome editing. It is believed that the inno
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Mikhaylova, Yu V., A. M. Nagornykh, V. V. Petrov, et al. Genetic Technologies. Edited by V. G. Akimkin. Central Research Institute for Epidemiology, 2020. http://dx.doi.org/10.36233/978-5-6045286-0-0.

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The book «Genetic Technologies» covers a wide range of topics in the field of genetic technologies related to genome editing, and summarizes the latest scientific data on the use of programmable nucleases in various fields related to genome modification. The monography «Genetic Technologies» will be interesting and useful for students of biological and medical universities, graduate students, young scientists, researchers, healthcare professionals and will help them to systematize knowledge in the rapidly developing field of genetic technologies and genome editing. It is believed that the inno
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