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Artykuły w czasopismach na temat „Thiazolo Quinoxaline”

Autor: Grafiati

Data publikacji: 5 czerwca 2025

Data aktualizacji: 1 sierpnia 2025

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1

Piltan, Mohammad. "One-Pot Synthesis of Thiazolo[3,4-a]Quinoxalines from 1,2-Diamines, Aryl Isothiocyanates and Ethyl Bromopyruvate." Journal of Chemical Research 41, no. 12 (2017): 712–14. http://dx.doi.org/10.3184/174751917x15127369231305.

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Some hitherto unreported thiazolo[3,4- a]quinoxaline derivatives have been synthesised in excellent yields via a one-pot, three-component reaction of benzene-1,2-diamines, ethyl bromopyruvate and aryl isothiocyanates in MeCN, for the first time. The protocol avoids the use of any catalysts or chromatographic separations and provides a wide range of novel thiazolo[3,4- a]quinoxalines.

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2

Ren, Demin, Xiaolian Hu, Yulin Huang, and Xiaofang Li. "Synthesis of Dispiro[Indeno[1,2-b]Quinoxaline-11,3′-Pyrrolizine-2′,2″-[1,3] Thiazolo[3,2-a]Pyrimidine Via Cycloaddition Reactions." Journal of Chemical Research 42, no. 9 (2018): 453–55. http://dx.doi.org/10.3184/174751918x15349264445767.

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The 1,3-dipolar cycloaddition reaction of ethyl 5-aryl-2-(2-methoxy-2-oxoethylidene)-7-methyl-3-oxo-2,3-dihydro-5 H-[1,3]thiazolo[3,2- a] pyrimidine-6-carboxylate and azomethine ylide, which was generated in situ by the reaction of 11 H-indeno[1,2- b]quinoxalin-11-one and L-proline, afforded novel 6″ethyl 1′-methyl 5″aryl-7″methyl-3″oxo-5’,6’,7’,7a′-tetrahydro-1' H,3″ H,5″ H-dispiro[indeno[1,2- b]quinoxaline-11, 3 ‘-pyrrolizine-2’,2″-[1,3]thiazolo[3,2- a]pyrimidine-1’,6″-dicarboxylates in good yields. The structures of all the products were characterised thoroughly by NMR, IR and HRMS together

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3

Y., A. AMMAR, M. ISMAIL I., M. SH. EL-SHARIEF A., A. MOHAMED Y., and M. AMER R. "Synthesis of some Newer Thiazolo and Thiadiazino Derivatives from 6-Methyl- or 6-Nitro-2,3-dichloroquinoxalines." Journal of Indian Chemical Society Vol. 66, Feb 1989 (1989): 124–27. https://doi.org/10.5281/zenodo.6303632.

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Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt <em>Manuscript received 23 October 1987, revised 18 August 1988, accepted 18 November 1988</em> lnteraction or 6-methyl or 6-nitro-2,3-dichloroquinoxaline (1a, b) with thiourea in ethanol led to the formation or diquinoxalino[2,3-<em>b</em>: 2',3'-<em>e</em>]-1,4-dithiien derivatives (2a, b) with 2-imino-2,3-dihydrothiazolol [4,5-<em>b</em> ]quinoxalines (3a, b). 7-Methyl- or 7- nitro-3-amino-2-imino-2,3-dihydrothiazolo[4,5-<em>b</em>]quinoxaline (6a, b) were prepared and reacted with acid

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4

Petrova, G. M., V. N. Charushin, N. G. Shcherbakova, M. S. Golod, and O. N. Chupakhin. "Antifungal activity of thiazolo[4,5-b]quinoxaline-2-thiones." Pharmaceutical Chemistry Journal 21, no. 7 (1987): 518–20. http://dx.doi.org/10.1007/bf00758767.

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5

Koti, A. S. R., B. Bhattacharjee, N. S. Haram, et al. "Photophysics of some styryl thiazolo quinoxaline dyes in organic media." Journal of Photochemistry and Photobiology A: Chemistry 137, no. 2-3 (2000): 115–23. http://dx.doi.org/10.1016/s1010-6030(00)00360-9.

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6

Abu-Hashem, Ameen Ali, and Sami A. Al-Hussain. "Design, Synthesis of New 1,2,4-Triazole/1,3,4-Thiadiazole with Spiroindoline, Imidazo[4,5-b]quinoxaline and Thieno[2,3-d]pyrimidine from Isatin Derivatives as Anticancer Agents." Molecules 27, no. 3 (2022): 835. http://dx.doi.org/10.3390/molecules27030835.

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The current work aims to design and synthesis a new series of isatin derivatives and greatly enhances their cytotoxic activity. The derivatives 3-((bromophenyl) imino)-1-(morpholino (pyridine) methyl) indolin-2-one, 2-((oxoindoline) amino) benzoic acid, 3-(thiazolo-imino) indolinone, ethyl-2-((oxoindolin-3-ylidene)amino)-benzothiophene-3-carboxylate, 1-(oxoindoline)-benzo[4,5] thieno [2,3-d]pyrimidin-4(1H)-one, ethyl-2-(2-oxoindoline) hydrazine-1-carboxylate, N-(mercapto-oxo-pyrimidine)-2-(oxoindoline) hydrazine-1-carboxamide, N-(oxo-thiazolo[3,2-a] pyrimidine)-2-(oxoindolin-ylidene) hydrazine

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7

Kathrotiya, Haresh G., Sagar P. Gami, and Yogesh T. Naliapara. "An Efficient and Clean Synthesis of Thiophenyl Thiazole Depended Novel Triazolo[4,3-a]Quinoxaline Derivatives." International Letters of Chemistry, Physics and Astronomy 51 (May 2015): 125–34. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.51.125.

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A simple and efficient approach for the synthesis of thiophenyl thiazole based triazolo [4,3-a] quinoxaline derivatives is described. In this methodology, 3-hydrazinyl-N-(4-(thiophen-2-yl) thiazol-2-yl) quinoxalin-2-amine derivatives treated with various aromatic aldehyde to form Schiff base which on treatment with iodobenzene diacetate in dichloromethane at room temperature to furnish title compounds. The synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data

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8

Kathrotiya, Haresh G., Sagar P. Gami, and Yogesh T. Naliapara. "An Efficient and Clean Synthesis of Thiophenyl Thiazole Depended Novel Triazolo[4,3-<i>a</i>]Quinoxaline Derivatives." International Letters of Chemistry, Physics and Astronomy 51 (May 15, 2015): 125–34. http://dx.doi.org/10.56431/p-flw9zc.

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A simple and efficient approach for the synthesis of thiophenyl thiazole based triazolo [4,3-a] quinoxaline derivatives is described. In this methodology, 3-hydrazinyl-N-(4-(thiophen-2-yl) thiazol-2-yl) quinoxalin-2-amine derivatives treated with various aromatic aldehyde to form Schiff base which on treatment with iodobenzene diacetate in dichloromethane at room temperature to furnish title compounds. The synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data

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9

Abdel-Aziz, Hatem A., Nehal A. Hamdy, Amira M. Gamal-Eldeen, and Issa M. I. Fakhr. "Synthesis of New 2-Substituted 6-Bromo-3-methylthiazolo[3,2-a]- benzimidazole Derivatives and their Biological Activities." Zeitschrift für Naturforschung C 66, no. 1-2 (2011): 7–16. http://dx.doi.org/10.1515/znc-2011-1-202.

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1-(6-Bromo-3-methyl-1,3-thiazolo[3,2-a]benzimidazol-2-yl)ethanone (2) was prepared by bromination at ambient temperature of 1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)ethanone (1). The structure of 2 was determined by single-crystal X-ray diffraction. The precursor 5 was synthesized by heating a mixture of acetyl 2 and bromine. Various 2-substituted 6-bromo-3-methylthiazolo[3,2-a]benzimidazoles containing 1,3-thiazole, 1,4-benzothiazine, quinoxaline or imidazo[1,2-a]pyridine moieties were prepared starting from bromoacetyl 5. Taken together from the biological investigations, 2, 5, and 7a wer

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10

Prasanna, B., B. Srinivas, Y. Jagannadham, and Sumangala Rao. "An Efficient Synthesis of Thiazolo and Thiadiazolo Quinoxaline Derivatives in Ionic Liquid." E-Journal of Chemistry 9, no. 2 (2012): 893–98. http://dx.doi.org/10.1155/2012/865414.

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A series of 3-substitutedphenyl-1-thia-tetrazopentaleno[1,2-b] naphthalene4(a-d)and 2-substitutedphenyl-1-thia-pentazopentaleno[1,2-b] naphthalene5(a-d)were synthesizedvia., the reaction of 2-aminothiazoles2(a-d)and 2-aminothiadiazoles3(a-d)with 2,3-dichloro quinoxaline1in ionic liquid without using any catalyst. This protocol has the advantages of easier workup, milder reaction conditions, high yields, and environmentally benign procedure over traditional methods. The synthesized compounds4(a-d)and5(a-d)tested for their anti-fungal activity and these compounds were characterized by IR, NMR an

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11

S., S. EL-MORSY, A. FADDA A., and S. EL-HOSSINI M. "Synthesis and Antimicrobial Activity of some New Thiazolo-, Quinoxalino-, Piperidino- and Naphthatriazino- coumarins." Journal of Indian Chemical Society Vol. 65, Oct 1988 (1988): 699–701. https://doi.org/10.5281/zenodo.6076858.

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Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt <em>Manuscript received 31 March 1987, revised 5 May 1988, accepted 8 July 1988</em> Various derivatives from 3-acetylcoumarin are prepared: aminothiazole (9), coumarilic acid ( )<em>, </em>piperidone (12), quinoxaline (14) and naphthatriazine (15). Active methylene compounds react with the arylidene (2a, b) to give the cyclohexanone derivatives (4a, b, respectively). SeO<sub>2</sub> on reaction with 1 gives the  <em>α</em>, <em>β</em> -diketon (13) which reacts with hydrazine to give 18

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12

Ammar, Y. A., M. S. A. El-gaby, M. A. Zahran, and A. A. Abdel-salam. "SOME REACTIONS WITH 6-BENZOYL-3-AMINO-2-IMINO-2,3- DIHYDROTHIAZOLO[4,5-b]QUINOXALINE: SYNTHESIS OF (1,2,4) TRIAZOLO[3′,2′:2,3]THIAZOLO[4,5-b] QUINOXALINE AND (1,3,4)THIADIAZINO [5,6-b]QUINOXALINE DERIVATIVES." Phosphorus, Sulfur, and Silicon and the Related Elements 157, no. 1 (2000): 87–95. http://dx.doi.org/10.1080/10426500008040514.

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13

Phadke, Ravindra Chintaman, and Dinesh Wamanrao Rangnekar. "Synthesis of 2-(Alkyl and Aryl)thiazolo[4,5-b]quinoxaline Derivatives and Study of Their Fluorescent Properties." Bulletin of the Chemical Society of Japan 59, no. 4 (1986): 1245–47. http://dx.doi.org/10.1246/bcsj.59.1245.

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14

Abid, Mohammad, and Amir Azam. "Synthesis, characterization and antiamoebic activity of 1-(thiazolo[4,5-b]quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives." Bioorganic & Medicinal Chemistry Letters 16, no. 10 (2006): 2812–16. http://dx.doi.org/10.1016/j.bmcl.2006.01.116.

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15

Kuklin, S., I. Konstantinov, A. Peregudov, et al. "Bis[1,3]Thiazolo[4,5-f:5’,4’-h]Thieno[3,4-b]Quinoxaline Derivatives — New Building Blocks for Organic Electronics." Доклады академии наук 482, no. 3 (2018): 297–301. http://dx.doi.org/10.31857/s086956520003120-5.

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16

Deshpande, Saurabh S., Haribhau S. Kumbhar, and Ganapati S. Shankarling. "Solvatochromic fluorescence properties of phenothiazine-based dyes involving thiazolo[4,5- b ]quinoxaline and benzo[ e ]indole as strong acceptors." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 174 (March 2017): 154–63. http://dx.doi.org/10.1016/j.saa.2016.10.045.

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17

Ammar, Yousry A., Awatef A. Farag, Abeer M. Ali, et al. "Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies." Bioorganic Chemistry 99 (June 2020): 103841. http://dx.doi.org/10.1016/j.bioorg.2020.103841.

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18

Abu-Hashem, A. A., M. A. Gouda, and F. A. Badria. "Synthesis of some new pyrimido[2′,1′:2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents." European Journal of Medicinal Chemistry 45, no. 5 (2010): 1976–81. http://dx.doi.org/10.1016/j.ejmech.2010.01.042.

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19

Budakoti, Asha, Abdul R. Bhat, Fareeda Athar, and Amir Azam. "Syntheses and evaluation of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline derivatives." European Journal of Medicinal Chemistry 43, no. 8 (2008): 1749–57. http://dx.doi.org/10.1016/j.ejmech.2007.10.026.

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20

Ghorab, Mostafa, Fatma Ragab, Helmy Heiba, Marwa El-Gazzar, and Mostafa El-Gazzar. "Synthesis, in vitro anticancer screening and radiosensitizing evaluation of some new 4-[3-(substituted)thioureido]-N-(quinoxalin-2-yl)-benzenesulfonamide derivatives." Acta Pharmaceutica 61, no. 4 (2011): 415–25. http://dx.doi.org/10.2478/v10007-011-0040-4.

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Synthesis, in vitro anticancer screening and radiosensitizing evaluation of some new 4-[3-(substituted)thioureido]-N-(quinoxalin-2-yl)-benzenesulfonamide derivatives Sulfonamides and quinoxaline derivatives possess many types of biological activities and have been recently reported to show substantial antitumor activity. This paper reports the synthesis of novel thioureido sulfaquinoxaline derivatives. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against a human liver cell line (HEPG2) and showed higher activity than the reference drug doxorubicin.

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21

Kathrotiya, Haresh G., and Yogesh T. Naliapara. "Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives." International Letters of Chemistry, Physics and Astronomy 51 (May 2015): 115–24. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.51.115.

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A new series of thiophenyl thiazole based novel quinoxaline derivatives 4a-4t have been synthesized by base catalysed condensation reaction. In which 6-substituted 2,3-dichloroquinoxaline 1a and 4-(thiophen-2-yl) thiazol-2-amine 2b reacted in basic condition to afford intermediate 3c which reacts with various aromatic amine to form final compounds. Easy experimental procedure, high yield, and selectivity are the imperative features of this method. The identity of all the compounds has been established by 1H NMR, 13C NMR, FT-IR, and elemental analysis.

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22

Kathrotiya, Haresh G., and Yogesh T. Naliapara. "Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives." International Letters of Chemistry, Physics and Astronomy 51 (May 15, 2015): 115–24. http://dx.doi.org/10.56431/p-oioid3.

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A new series of thiophenyl thiazole based novel quinoxaline derivatives 4a-4t have been synthesized by base catalysed condensation reaction. In which 6-substituted 2,3-dichloroquinoxaline 1a and 4-(thiophen-2-yl) thiazol-2-amine 2b reacted in basic condition to afford intermediate 3c which reacts with various aromatic amine to form final compounds. Easy experimental procedure, high yield, and selectivity are the imperative features of this method. The identity of all the compounds has been established by 1H NMR, 13C NMR, FT-IR, and elemental analysis.

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23

Kuklin, S. A., I. O. Konstantinov, A. S. Peregudov, et al. "Bis[1,3]thiazolo[4,5-f:5',4'-h]thieno[3,4-b]quinoxaline Derivatives as New Building Blocks of Polymers for Organic Electronics." Doklady Chemistry 482, no. 1 (2018): 207–11. http://dx.doi.org/10.1134/s0012500818090070.

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24

Ramadan, El Sayed, Hamida M. Abdel Hamid, Sawsan A. Noureddin, and Khadija O. Badahdah. "Synthesis, characterization, and antitumor activity of some novel S-functionalized benzo[d]thiazole-2-thiol derivatives; regioselective coupling to the –SH group." Zeitschrift für Naturforschung B 73, no. 9 (2018): 647–54. http://dx.doi.org/10.1515/znb-2018-0078.

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AbstractSeveral 2-substituted sulfanyl benzo[d]thiazoles were regioselectively synthesized by the reaction of benzo[d]thiazole-2-thiol (1a) with a variety of reagents under different basic conditions. Some 2-(2,3-disubstituted propyl sulfanyl)benzo[d]thiazoles were obtained from 2-(allylthio)benzo[d]thiazole, which was prepared by the allylation of 1a with allyl bromide in the presence of sodium hydride in dry N,N-dimethylformamide. Reaction of 1a with various pyrazolyl-quinoxaline derivatives was also investigated. Better yields and shorter reaction time were achieved for the synthesis of som

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Mamedov, V. A., I. Z. Nurkhametova, S. K. Kotovskaya, et al. "Fused polycyclic nitrogen-containing heterocycles 11. 4-Hydroxy-3,5-diphenyl-2-phenyliminothiazolidines as new key compounds in the synthesis of thiazolo[3,4-a]quinoxaline derivatives." Russian Chemical Bulletin 53, no. 11 (2004): 2568–76. http://dx.doi.org/10.1007/s11172-005-0156-0.

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Ragab, Ahmed, Doaa M. Elsisi, Enayat M. Elqady, et al. "New prospective insecticidal agents based on thiazolo[4,5-b]quinoxaline derivatives against cotton leafworm Spodoptera litura (Fabricius): Design, synthesis, toxicological, morphology, histological, and biomedical studies." Pesticide Biochemistry and Physiology 202 (June 2024): 105943. http://dx.doi.org/10.1016/j.pestbp.2024.105943.

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Elgogary, Sameh R., and Emad M. El-Telbani. "Synthesis of tricyclic fused quinoxaline ring systems: Isoxazolo-, oxazolo-, isothiazolo- and thiazoloquinoxalines (a review)." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 263. https://doi.org/10.59467/ijhc.2025.35.263.

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Quinoxaline derivatives have gained great interest because they exhibit a variety of pharmacological activities, including antibacterial, antitubercular, antiviral, anti-HIV, anti-inflammatory, antifungal, anticancer, antiproliferative, antitumor, kinase inhibition, antimicrobial, antioxidant, and analgesic effects. Recognizing the importance of these bioactive quinoxaline derivatives, researchers have dedicated their efforts to develop different synthetic routes for their production. This review aims to compile the most recent findings on the synthesis of quinoxaline derivatives incorporating

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Kathrotiya, Haresh G., and Yogesh T. Naliapara. "Synthesis of some New Quinoxalines Bearing Pyridinyl Thiazole Moiety." International Letters of Chemistry, Physics and Astronomy 52 (June 2015): 74–83. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.52.74.

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Keeping the objective to build up a new structural class of quinoxaline, a new series of quinoxaline derivatives bearing the pyridinyl thiazole nucleus have been synthesized by base-catalyzed chloro-amine condensation reaction approach. The protocol offers expeditious and easy synthesis with excellent yield. The chemical structures of the synthesized compounds were elucidated by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data.

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Kathrotiya, Haresh G., and Yogesh T. Naliapara. "Synthesis of some New Quinoxalines Bearing Pyridinyl Thiazole Moiety." International Letters of Chemistry, Physics and Astronomy 52 (June 2, 2015): 74–83. http://dx.doi.org/10.56431/p-6a7g5l.

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Keeping the objective to build up a new structural class of quinoxaline, a new series of quinoxaline derivatives bearing the pyridinyl thiazole nucleus have been synthesized by base-catalyzed chloro-amine condensation reaction approach. The protocol offers expeditious and easy synthesis with excellent yield. The chemical structures of the synthesized compounds were elucidated by 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectral data.

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Kathrotiya, Haresh G., and Yogesh T. Naliapara. "Synthesis of Novel Triazolo[4,3-a]Quinoxaline Darivatives Containing Pyridinyl and Thiazole Nucleous." International Letters of Chemistry, Physics and Astronomy 52 (June 2015): 63–73. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.52.63.

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On pursuing research about [1,2,4] triazolo [4,3-a] quinoxaline, in this paper we report a small library of novel class of [1,2,4] triazolo [4,3-a] quinoxaline derivatives containing pyridinyl thiazole moiety. Particularly valuable features of this method include high yield, broad substrate scope, shorter reaction time and straightforward procedure. The structures of new compounds have been characterized on the basis of elemental analysis, FT-IR, 1H NMR, 13C NMR, and mass spectral data.

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Kathrotiya, Haresh G., and Yogesh T. Naliapara. "Synthesis of Novel Triazolo[4,3-<i>a</i>]Quinoxaline Darivatives Containing Pyridinyl and Thiazole Nucleous." International Letters of Chemistry, Physics and Astronomy 52 (June 2, 2015): 63–73. http://dx.doi.org/10.56431/p-c28218.

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On pursuing research about [1,2,4] triazolo [4,3-a] quinoxaline, in this paper we report a small library of novel class of [1,2,4] triazolo [4,3-a] quinoxaline derivatives containing pyridinyl thiazole moiety. Particularly valuable features of this method include high yield, broad substrate scope, shorter reaction time and straightforward procedure. The structures of new compounds have been characterized on the basis of elemental analysis, FT-IR, 1H NMR, 13C NMR, and mass spectral data.

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Kalinin, A. A., O. G. Isaikina, and V. A. Mamedov. "Spirothiazolo[4?,2]- and thiazolo-[3,4-a]quinoxalines based on 3-(?-bromoethyl)quinoxalin-2-ones and thiourea." Chemistry of Heterocyclic Compounds 40, no. 11 (2004): 1510–12. http://dx.doi.org/10.1007/s10593-005-0024-8.

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Kalinin, A. A., and V. A. Mamedov. "Carbon Disulfide in Synthesis of Thiazolo[3,4-a]quinoxalines Based on 3-( -Chlorobenzyl)quinoxalin-2-(1H)-ones." Chemistry of Heterocyclic Compounds 40, no. 1 (2004): 129–31. http://dx.doi.org/10.1023/b:cohc.0000023785.83340.ac.

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Feng, Ru, Zuoxu Chen, Yue Wang, Jianming Pan, and Soji Shimizu. "Facile Synthesis of Asymmetric aza-Boron Dipyrromethene Analogues Bearing Quinoxaline Moiety." Molecules 28, no. 24 (2023): 7940. http://dx.doi.org/10.3390/molecules28247940.

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An asymmetric aza-BODIPY analogue bearing quinoxaline moiety was synthesized via a titanium tetrachloride-mediated Schiff-base-forming reaction of 6,7-dimethyl-1,4-dihydroquinoxaline-2,3-dione and benzo[d]thiazol-2-amine. This novel aza-BODIPY analogue forms a complementary hydrogen-bonded dimer due to the quinoxaline moiety in the crystal structure. It also shows intense absorption and fluorescence, with fluorescence quantum yields close to unity. The electrochemical measurements and the DFT calculations revealed the presence of the low-lying HOMO, which benefits their potential applications

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H., Abdellatif, and Abd El Rady E. "Facile route for the synthesis and characterization of new naphtho[2,3-f]quinoxaline-dione, trione and anthra-dione derivatives." Chemistry International 6, no. 3 (2020): 122–30. https://doi.org/10.5281/zenodo.3552253.

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In the present study, addition of nitroso group at position 1 of 2-aminoanthraquinone (1) to yield 2-amino-1-nitroanthraquinone (2) was carried out by the reaction of compound (1) with sodium nitrite in water. Compound (2) was used as starting material to produce many new naphtho[2,3-<em>f</em>] quinoxaline-dione, trione, naphtho-pyrazole quinoxaline-dione, anthra-triazine-dione, naphtho-thiazole quinoxaline-dione and anthrabenzo-triazepine-dione derivatives by elimination of one molecule of water as an initial reaction step. The reacting moieties were nitroso and amino function groups to yiel

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Keshtov, Mukhamed L., Sergei A. Kuklin, Igor O. Konstantinov, et al. "Conjugated random terpolymers based on benzodithiophene, diketopyrrolopyrrole, and 8,10‐bis(thiophen‐2‐yl)‐2,5‐di(nonadecan‐3‐yl)bis[1,3]thiazolo[4,5‐ f :5′,4′‐ h ]thieno[3,4‐ b ]quinoxaline for Efficient Polymer Solar Cell." Journal of Polymer Science Part A: Polymer Chemistry 57, no. 13 (2019): 1478–85. http://dx.doi.org/10.1002/pola.29412.

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Yadav, Amar, and Vinod Pandey. "Multistep organic synthesis leading to the formation of triazinothiazoloquinoxalines involving cost effective rea-gents." International Journal of Scientific World 5, no. 2 (2017): 131. http://dx.doi.org/10.14419/ijsw.v5i2.6154.

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A simple and efficient chemical method has been attempted for the synthesis of biologically and commercially important 2-aryl [-s-] triazino [1], [3], [5] thiazolo [6], [5-b] quinoxalin -4- thiones in moderate to excellent yields through cyclization reaction of o-phenylenediamino using readily available and fewer costly reagents viz. oxalic acid, PCl5thiourea, aromatic aldehydes and ammonium thiocyanate at an ambient temperature.

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Babu, Lavanya Thilak, Gajanan Raosaheb Jadhav, and Priyankar Paira. "Luminescent bis(benzo[d]thiazolyl)quinoxaline: facile synthesis, nucleic acid and protein BSA interaction, live-cell imaging, biopharmaceutical research and cancer theranostic application." RSC Advances 9, no. 16 (2019): 8748–52. http://dx.doi.org/10.1039/c9ra01498e.

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A series of luminescent bis(benzo[d]thiazolyl)quinoxalines have been synthesized and their fluorescence properties, anticancer potency, DNA and BSA interactions, cellular uptake, and metabolic stabilities are investigated.

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Benchidmi, M., E. M. Essassi, S. Ferfra, and J. Fifani. "Synthèse Facile de Nouvelles Thiazolo [3,4-a] Quinoxalines." Bulletin des Sociétés Chimiques Belges 102, no. 10 (2010): 679–82. http://dx.doi.org/10.1002/bscb.19931021009.

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Ammar, Y. A., I. M. Ismail, A. M. Sh. El-Sharief, Y. A. Mohamed, and R. M. Amer. "Synthesis of Thiazolo(4,5-b)-quinoxalines and related compounds." Journal f�r Praktische Chemie 330, no. 3 (1988): 421–27. http://dx.doi.org/10.1002/prac.19883300312.

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Vaishnani, M. J., and V. D. Jain. "GREEN SYNTHESIS OF 1,4- DISUBSTITUTED 1,2,3- TRIAZOLE ACETAMIDE DERIVATIVES BY UTILIZING THE CLICK CHEMISTRY APPROACH." RASAYAN Journal of Chemistry 16, no. 02 (2023): 811–19. http://dx.doi.org/10.31788/rjc.2023.1628271.

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A library of 1,4-disubstituted 1,2,3-triazole acetamide derivatives has been designed and synthesized via a click chemistry approach by using thiazole acetamide azide and acetylene derivative of quinoxaline is described. All the final compounds obtained in an excellent yield (>90%) and were well characterized by analytical spectroscopic methods like 1H NMR, 13C NMR, and Mass spectroscopy. The work reported herewith demonstrates the importance of green chemical synthesis using alternative solvents (water & n-butanol) in experiments to reduce the environmental impact of chemical processes

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BENCHIDMI, M., E. M. ESSASSI, S. FERFRA, and J. FIFANI. "ChemInform Abstract: Facile Synthesis of Novel Thiazolo(3,4-a)quinoxalines." ChemInform 25, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.199432157.

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de Mattos, Marcio, та Vitor de Andrade. "One-Pot Telescoped Synthesis of Thiazole Derivatives from β-Keto Esters and Thioureas Promoted by Tribromoisocyanuric Acid". Synthesis 50, № 24 (2018): 4867–74. http://dx.doi.org/10.1055/s-0037-1610243.

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A simple and efficient one-pot protocol has been developed for the synthesis of thiazole derivatives from readily available starting materials. Tribromoisocyanuric acid was successfully used for α-monohalogenation of β-keto esters in aqueous medium, which in the presence of thiourea and DABCO produced the corresponding 2-aminothiazoles in up to 87% yield. Extension of the reaction to thioacetamide and o-phenylenediamine led to 2-methylthiazole and quinoxalines, respectively. This approach enables telescoping of the two steps into a single process.

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Liu, Xiang, Yu Huang, Xu Meng, et al. "Recent Developments in the Synthesis of Nitrogen-Containing Heterocycles through C–H/N–H Bond Functionalizations and Oxidative Cyclization." Synlett 30, no. 09 (2019): 1026–36. http://dx.doi.org/10.1055/s-0037-1611476.

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The synthesis and structure of nitrogen-containing heterocycles are fascinating because these compounds have a great richness of structural, physicochemical, and biological properties. Therefore, the development of improved ways for the synthesis of polyfunctional nitrogen-containing heterocycles continues to be a challenging goal. This account describes developments in the discovery of C–H/N–H bond functionalization and oxidative cyclization procedures for the synthesis of nitrogen-containing heterocycles (aziridines, indoles, indolizines, triazoles, imidazoles, oxazoles, thiazoles, quinoxali

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Foize Ahmad, G., A. Syed Mohammed Mujaheer, M. NizamMohideen, M. Gulam Mohamed, and V. Viswanathan. "The crystal structures and Hirshfeld surface analysis of 6-(naphthalen-1-yl)-6a-nitro-6,6a,6b,7,9,11a-hexahydrospiro[chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazole-11,11′-indeno[1,2-b]quinoxaline] and 6′-(naphthalen-1-yl)-6a′-nitro-6′,6a′,6b′,7′,8′,9′,10′,12a′-octahydro-2H-spiro[acenaphthylene-1,12′-chromeno[3,4-a]indolizin]-2-one." Acta Crystallographica Section E Crystallographic Communications 75, no. 10 (2019): 1519–24. http://dx.doi.org/10.1107/s205698901901291x.

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The title compounds, 6-(naphthalen-1-yl)-6a-nitro-6,6a,6 b,7,9,11a-hexahydrospiro[chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazole-11,11′-indeno[1,2-b]quinoxaline], C37H26N4O3S, (I), and 6′-(naphthalen-1-yl)-6a′-nitro-6′,6a′,6b′,7′,8′,9′,10′,12a′-octahydro-2H-spiro[acenaphthylene-1,12′-chromeno[3,4-a]indolizin]-2-one, C36H28N2O4, (II), are new spiro derivatives, in which both the pyrrolidine rings adopt twisted conformations. In (I), the five-membered thiazole ring adopts an envelope conformation, while the eight-membered pyrrolidine-thiazole ring adopts a boat conformation. An intramolecular C—H...N

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Rybakova, A., and A. Eynik. "Synthesis and heterocyclization of a previously unknown S-allylthiosemicarbazone of 11H-indeno[1,2-b]quinoxaline-11-one." Bulletin of the South Ural State University series "Chemistry" 16, no. 4 (2024): 133–43. https://doi.org/10.14529/chem240413.

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It is known that some derivatives of indenoquinoxaline prove to be biologically active compounds. Synthesis of 11H-indeno[1,2-b]quinoxalin-11-one has been known since about 1910, and since then considerable information has been accumulated about one of its most practically significant deriva-tives: thiosemicarbazone of indeno[1,2-b]quinoxalin-11-one. We studied the latter in the reaction with allyl bromide in a DMF-KOH-H2O medium at room temperature, which is of great interest from the point of view of obtaining S-derivatives of thiosemicarbazone of indeno[1,2-b]quinoxalin-11-one, information

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Camoutsis, Charalambos, Panayotis Catsoulacos, and C. I. Stassinopoulou. "Steroidal lactam quinoxalines, lactam indoles, and lactam thiazoles." Journal of Chemical & Engineering Data 32, no. 1 (1987): 122–23. http://dx.doi.org/10.1021/je00047a034.

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Elsisi, Doaa M., Moustafa S. Abusaif, Eman El-Said, et al. "Synthesis and modification of novel thiazole-fused quinoxalines as new insecticidal agents against the cotton leafworm Spodoptera litura: design, characterization, in vivo bio-evaluation, toxicological effectiveness, and study their mode of action." RSC Advances 15, no. 2 (2025): 1391–406. https://doi.org/10.1039/d4ra08096c.

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Khan, Salman Ahmad, Kishwar Saleem, and Zaheer Khan. "Synthesis, characterization and in vitro antibacterial activity of new steroidal thiazolo quinoxalines." European Journal of Medicinal Chemistry 42, no. 1 (2007): 103–8. http://dx.doi.org/10.1016/j.ejmech.2006.07.006.

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Journal, Baghdad Science. "Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings." Baghdad Science Journal 5, no. 3 (2008): 440–45. http://dx.doi.org/10.21123/bsj.5.3.440-445.

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In this study, new heterocyclic compounds were synthesized through the cyclization reactions of o-phenylenediamine (1) with various organic reagents. Benzodiazepine derivatives (2-4) were obtained by reaction of (1) with ethylacetoacetate, malonic acid and acetyl acetone.Treatment of compound (1) with chloroacetamide, chloroacetic acid, p-bromophenacyl bromide and oxalic acid dihydrate afforded quinoxaline derivatives (5-8), respectively. Reaction of compound (1) with benzoic acid, piperonal, cyclohexanone and carbon disulfide resulted in the formation of compounds (9-12), respectively. Finall

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