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Artykuły w czasopismach na temat „Thiol disulfide homeostasis”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Georgescu, Simona Roxana, Cristina Iulia Mitran, Madalina Irina Mitran, et al. "Thiol-Disulfide Homeostasis in Skin Diseases." Journal of Clinical Medicine 11, no. 6 (2022): 1507. http://dx.doi.org/10.3390/jcm11061507.

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Oxidative stress represents the imbalance between oxidants and antioxidants and has been associated with a wide range of diseases. Thiols are the most important compounds in antioxidant defense. There is an equilibrium between thiols and their oxidized forms, disulfides, known as dynamic thiol-disulfide homeostasis (TDH). In 2014, Erel and Neselioglu developed a novel automated assay to measure thiol and disulfide levels. Subsequently, many researchers have used this simple, inexpensive and fast method for evaluating TDH in various disorders. We have reviewed the literature on the role of TDH

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Fadime, Kilinc, Sener Sertac, Akbas Ayse, Neselioglu Salim, Erel Ozcan, and Aktas Akin. "Investigation of Dynamic Thiol-Disulfide Homeostasis in Alopecia Areata Patients." British Journal of Medicine & Medical Research 21, no. 6 (2017): 1–7. https://doi.org/10.9734/BJMMR/2017/33535.

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<strong>Background: </strong>Thiols are antioxidant, organic compounds containing sulfhydryl group on their active sites. They have important roles on preventing oxidative stress. The thiol disulfide homeostasis has a vital importance in organism. Thiol disulfide imbalance is an early indicator of oxidative stress. Alopecia areata is an autoimmune skin disorder characterized with scar-free hair loss. Its pathogenesis is still unclear. Thiol disulfide homeostasis in these patients has not been studied at all. <strong>Objective: </strong>To evaluate the thiol disulfide homeostasis in alopecia ar

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3

YILMAZ, Yücel, Şaban KELEŞOĞLU, Kemal TEKİN, et al. "A New Biomarker in The Distinction Between Stable Coronary Artery Disease and Acute Coronary Syndrome:Thiols." Journal of Contemporary Medicine 12, no. 4 (2022): 1–6. http://dx.doi.org/10.16899/jcm.981853.

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Backraund; Thiols are important elements for oxidation reactions and under oxidative stress. The aim of this study was to determine thiole levels, an antioxidative marker in CAD patients with stable and acute coronary syndrome.  Methods; 210 of the patients included in the study were diagnosed with acute coronary syndrome (ACS), 205 consisted of patients with stable angina pectoris (SAP). Thiol groups levels and thiol/disulphide homeostasis was measured by spectrophotometrically.  Results: Native thiol and total thiol levels, disulfide/natural thiol and disulfide/total thiol ratios

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Asil, Mehmet, Ramazan Dertli, Murat Biyik, et al. "Dynamic thiol-disulfide homeostasis is disturbed in patients with non-alcoholic fatty liver disease." LaboratoriumsMedizin 42, no. 1-2 (2018): 31–38. http://dx.doi.org/10.1515/labmed-2017-0018.

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AbstractBackground:Oxidative stress has been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Plasma thiols are major defense mechanisms against oxidative stress and undergo oxidation to form disulfides under oxidative conditions. This study was conducted to investigate thiol-disulfide homeostasis in NAFLD patients.Methods:Thirty patients with biopsy proven non-alcoholic steatohepatitis (NASH), 40 patients with simple steatosis and 50 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measu

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5

Ozyurt, Songul, Neslihan Ozcelik, Bilge Yilmaz Kara, et al. "Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis." Canadian Respiratory Journal 2022 (January 29, 2022): 1–6. http://dx.doi.org/10.1155/2022/8340450.

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Purpose. Thiols are sulfhydryl-containing organic compounds that have an important role in preventing cellular oxidative stress. This study compares the blood oxidative stress marker levels in bronchiectasis cases during their stable periods with healthy controls. Materials and Methods. Seventy-seven patients (49 patients with stable bronchiectasis/28 healthy controls), followed up by the chest disease clinic, were included in the study. Peripheral blood thiol-disulfide parameters (NT: native thiol (−SH); TT: total thiol (−SH + SS); SS: disulfide (−SS); SS-SH: disulfide/native thiol index; SS-

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6

Yazıcı, Mutlu U., Ganime Ayar, Semra Çetinkaya, et al. "Evaluation of Thiol/Disulfide Homeostasis in Pediatric Patients with Diabetic Ketoacidosis." Combinatorial Chemistry & High Throughput Screening 23, no. 3 (2020): 185–90. http://dx.doi.org/10.2174/1386207323666200218114331.

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Aim and Objective: This study aimed to investigate the value of Thiol/Disulfide homeostasis in pediatric diabetic ketoacidosis patients suffering from type 1 diabetes mellitus. Materials and Methods: This study featured children who were diagnosed with diabetic ketoacidosis and who were consecutively admitted to pediatric intensive care within one year of their diagnosis. Thiol/disulfide homeostasis was evaluated in 45 pediatric patients suffering from DKA, as well as 45 healthy controls of parallel gender and age. Thiol/disulfide homeostasis parameters were measured using a novel automated me

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7

Matei, Clara, Simona Roxana Georgescu, Ilinca Nicolae, et al. "Variations of Thiol–Disulfide Homeostasis Parameters after Treatment with H1-Antihistamines in Patients with Chronic Spontaneous Urticaria." Journal of Clinical Medicine 10, no. 13 (2021): 2980. http://dx.doi.org/10.3390/jcm10132980.

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Background. The pathogenesis of chronic spontaneous urticaria involves metabolic, immunological, and psychological factors. The thiol–disulfide exchange reactions could be a mechanism to counteract oxidative stress in patients with chronic spontaneous urticaria. Objective: The assessment of thiol–disulfide homeostasis parameters (TDHPs) according to disease severity and the influence of H1-antihistamine therapy in patients with chronic spontaneous urticaria. Material and method. We have included 30 patients with chronic spontaneous urticaria in the study and we have determined the levels of na

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8

Bayatkara Yilmaz, Tugba, Elif Karalı, Özgür Mehmet Yis, and Akif Güneş. "Dynamic Thiol / Disulfide Homeostasis In Patients With Nasal Polyps And The Effects Of Smoking On Homeostasis Parameters." Abant Medical Journal 14, no. 1 (2025): 19–27. https://doi.org/10.47493/abantmedj.1594807.

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Abstract Objective: The study aimed to determine the dynamic thiol/disulfide homeostasis for measuring oxidative stress and the impacts of smoking on these parameters in nasal polyps (NP) patients. Materials and methods: A total of forty NP patients and 36 healthy volunteers participated in the current study. Participants were categorized into two groups: 20 smokers and 20 non-smokers. Erel and Neşelioğlu developed an automated method to analyze thiol-disulfide homeostasis parameters in samples of serum from the participants. Groups were compared. Each parameter related to thiol/disulfide home

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9

Pektaş, Gökhan, Suzan Pektaş, Aynure Öztekin, et al. "Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo." Archives of Biological Sciences 71, no. 1 (2019): 55–62. http://dx.doi.org/10.2298/abs181003047p.

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Vitiligo is a multifactorial disorder commonly associated with hypo-/depigmentation in the skin and may influence both children and adults psychologically because of the notable leopard-skin-like appearance. This study was designed to investigate the thiol/disulfide homeostasis in patients with generalized vitiligo and to determine its relationship with some of the demographical characteristics. Seventy-six generalized vitiligo patients and 67 healthy individuals were included in the study. Blood serum native thiol, disulfide and total thiol concentrations, together with some hematological par

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10

Kazanci, Elif Guler, Deniz Guven, Ayse Oren, Yasemin Ustundag, Ozcan Erel, and Funda Eren. "Thiol-disulfide homeostasis in children with febrile neutropenia." Atlantic Journal of Medical Science and Research 2, no. 2 (2022): 20–24. http://dx.doi.org/10.55358/atjmed.2022.05.06.

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Aim: The body’s antioxidant system processes rely on thiol-disulfide equilibrium to function correctly. The purpose of this study was to look into dynamic thiol/disulfide homeostasis (TDH) as an endogenous antioxidant indicator in febrile neutropenic (FN) children with acute lymphoblastic leukemia (ALL). Materials and methods: The study included 66 acute lymphoblastic leukemia patients, including 33 with FN and 33 controls. Both groups were compared for TDH and ischemia-modified albumin (IMA). TDH parameters were assessed using a unique spectrophotometric approach disclosed earlier by Neşelioğ

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11

Arican, Sule, Gulcin Hacibeyoglu, Sinan Oguzhan Ulukaya, et al. "Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia." Journal of Laboratory Medicine 43, no. 5 (2019): 257–63. http://dx.doi.org/10.1515/labmed-2018-0211.

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Abstract Background Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to

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12

Nar, Rukiye, and Aliye Gamze Çalış. "Assessment of dynamic thiol/disulfide homeostasis in patients with asthma." LaboratoriumsMedizin 42, no. 3 (2018): 99–104. http://dx.doi.org/10.1515/labmed-2017-0144.

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Abstract Background: Asthma is a chronic inflammatory lung disease and oxidative stress is an important component in airway inflammation. This study aims to investigate dynamic thiol/disulfide homeostasis in patients with asthma. Methods: A total of 103 subjects, including 56 patients with asthma and 47 healthy controls, of similar age and gender were included in the study. The native thiol, total thiol and disulfide levels and the disulfide-native thiol, disulfide-total thiol and native thiol-total thiol ratios were analyzed and compared between the asthma and control groups using a novel aut

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13

Tuzcu, Ayca, Rabia Aydogan Baykara, Ahmet Omma, et al. "Thiol/Disulfide homeostasis in patients with rheumatoid arthritis." Romanian Journal of Internal Medicine 57, no. 1 (2019): 30–36. http://dx.doi.org/10.2478/rjim-2018-0025.

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Abstract Background. Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis. Material and methods. A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods. Results. Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared

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14

Tuzcu, Ayca, Rabia Aydogan Baykara, Murat Alışık, et al. "Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome." Acta Medica (Hradec Kralove, Czech Republic) 62, no. 1 (2019): 12–18. http://dx.doi.org/10.14712/18059694.2019.40.

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Background: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. Material and methods: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel’s novel methods. Results: Native thiol (330.6 ± 46.1

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15

Atalay Mert, Sule, Berna Dilbaz, Tugba Kinay, et al. "Evaluation of Oxidative Stress with "Dynamic Thiol/Disulfide Homeostasis" in Cases with Endometrioma." Medical Science and Discovery 9, no. 8 (2022): 458–64. http://dx.doi.org/10.36472/msd.v9i8.784.

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Objective: This preliminary study aims to use "dynamic thiol/disulfide homeostasis" with the new Erel method to evaluate the effect of oxidative stress in patients with endometrioma. Material and Method: The study group consisted of 40 cases with histologically confirmed endometrioma, and 40 women with no laparoscopically confirmed endometriosis were taken as the control group. Plasma thiol, total thiol (TT), and disulfide (SS) levels were measured with the new, fully automatic method described by Erel and Neselioglu. Serum Ca-125, sedimentation (Sed), C-reactive Protein (CRP), and thiol/disul

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16

Yesilirmak, Nilufer, Ozge Saritas, Busra Kurt, Salim Neselioglu, Akin Aktas, and Ozcan Erel. "Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes." Journal of Clinical Medicine 13, no. 14 (2024): 4052. http://dx.doi.org/10.3390/jcm13144052.

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Background/Objective: The aim of this study was to compare thiol/disulfide homeostasis and clinical parameters of rosacea patients across skin subtypes of the disease and healthy controls. Methods: This prospective study included 90 rosacea patients with different skin subtypes (phymatous, erythematotelangiectatic and papulopustular) and ocular involvement and 30 healthy controls. Plasma native thiol (NT), total thiol (TT) and disulfide levels of the patients and controls were measured using an automated spectrophotometric method, and disulfide/native thiol ratio (DNTR), disulfide/total thiol

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17

Buyuk, Gul Nihal, Zeynep Asli Oskovi Kaplan, Umit Yasemin Sert, et al. "Is There A Relationship Between The Umbilical Cord Coiling Index And Oxidative Stress Markers And SGA Fetuses?" Medical Science and Discovery 8, no. 5 (2021): 310–14. http://dx.doi.org/10.36472/msd.v8i5.538.

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Objective: We aimed to investigate the relationship between umblical coiling index and thiol/disulfide balance in SGA newborns to compare with AGA newborns. Material and Methods: Fetal umbilical cord serum samples were collected during labour and the thiol/disulfide homeostasis was measured. After birth, umbilical cords were collected and cord parameters were examined including, length, number of coils, umbilical cord index. Results: Significant decrease in native thiol, total thiol, and a significant increase in disulfide, disulfide/native thiol ratio and disulfide/total thiol rat

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18

Karaaslan, Ozgul, Yunus Hacımusalar, Ceylan Bal, and Müjgan Ercan. "Evaluation of thiol/disulfide homeostasis in patients with a first episode of major depressive disorder." Medical Science and Discovery 6, no. 1 (2019): 1–7. https://doi.org/10.36472/msd.v6i1.193.

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Objective: The aim of this study was to investigate the role of dynamic thiol-disulfide homeostasis as a new oxidative stress parameter in patients with major depressive disorder (MDD). Material and Methods: Sixty-three patients with their first episode of untreated MDD, and 61 healthy volunteers were included in the study. Serum thiol/disulfide levels were measured in fasting blood samples. The data were compared between the two groups. Results: No significant difference was observed between the two groups in terms of age, gender distribution, or body mass index. Plasma native and total thiol

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19

Şener, Alp, Gülhan Kurtoğlu Çelik, Ayhan Özhasenekler, et al. "Evaluation of dynamic thiol/disulfide homeostasis in adult patients with community-acquired pneumonia." Hong Kong Journal of Emergency Medicine 26, no. 6 (2018): 343–50. http://dx.doi.org/10.1177/1024907918802956.

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Background: Community-acquired pneumonia is an important cause of mortality and morbidity in all age groups. Oxidant and antioxidant mechanisms play an important role in the pathogenesis and mortality of community-acquired pneumonia. Objectives: In this study, the role of thiol/disulfide homeostasis in the diagnosis and prognosis of community-acquired pneumonia was investigated. Methods: This was a prospective, controlled, observational study involving 73 community-acquired pneumonia patients and 68 healthy volunteers. Results: The native thiol and total thiol, which are thiol/disulfide homeos

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Karataş, M., TN Öziş, M. Büyükşekerci, et al. "Thiol-disulfide homeostasis and ischemia-modified albumin levels as indicators of oxidative stress in welders’ lung disease." Human & Experimental Toxicology 38, no. 11 (2019): 1227–34. http://dx.doi.org/10.1177/0960327119871093.

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Welders’ lung disease refers to mixed exposure to different kinds of metals and chemicals from welding fumes, which affect all parts of the respiratory tract including airways and parenchyma together. This study aimed to investigate the oxidative status in patients with welders’ lung (PWL) by means of thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels. The male welder workers diagnosed with welders’ lung disease and healthy individuals were recruited in the study. Plasma levels of disulfide, disulfide/native thiol ratio, disulfide/total thiol ratio, IMA, and catalase (CAT)

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Gürlek, Beril, Murat Alan, Sabri Çolak, Özgür Önal, Özcan Erel, and Cemile Biçer. "Dynamic thiol/disulfide homeostasis in gestational diabetes mellitus: Is it related with adverse perinatal outcomes?" Medical Science and Discovery 6, no. 9 (2019): 198–204. http://dx.doi.org/10.36472/msd.v6i9.293.

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Objective: Aims of the study is to specify the significance of thiol/disulfide homeostasis in the aspect of gestational diabetes mellitus (GDM) and GDM-related complications. Material and Methods: This study is a prospective review of the data of 61 healthy and non-pregnant women, 58 healthy pregnant women, and 62 pregnant women with GDM. Results: The patients with gestational diabetes mellitus had significantly higher disulfide/native thiol and disulfide/total thiol concentrations than non-pregnant patients (p<0.001 for both) and healthy pregnant patients (p: 0.015 and p: 0.018

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22

Kütük, Ayşegül, Fatma Akar, and Gökhan Sadi. "Changes in hepatic thiol contents and regulation of glutathione S-transferase by high-fructose diet: Effects of kefir and some probiotic bacteria." HEALTH SCIENCES QUARTERLY 3, no. 2 (2023): 127–37. http://dx.doi.org/10.26900/hsq.1942.

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In this study, thiol/disulfide homeostasis in the liver tissues of high-fructose-fed rats was investigated in conjunction with the changes in the main hepatic detoxification enzyme, glutathione S-transferase (GST). Additionally, the effects of well-known probiotics namely Kefir, Lactobacillus helveticus, and Lactobacillus plantarum supplementation on the thiol/disulfate contents and GST activity and gene expression levels were analyzed. Fructose, administered as a 20% solution in drinking water for 15 weeks, developed an animal model of metabolic syndrome in male Wistar rats. Kefir, L. helveti

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23

Pálla, Tamás, Béla Noszál, and Arash Mirzahosseini. "Prediction of Antioxidant Capacity of Thiolate–Disulfide Systems Using Species-Specific Basicity Values." Antioxidants 13, no. 9 (2024): 1053. http://dx.doi.org/10.3390/antiox13091053.

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The principal reactions that maintain redox homeostasis in living systems are the deprotonation of thiols, followed by the oxidative conversion of the produced thiolates into disulfides, which thus reduce the harmful oxidizing agents. The various biological thiols have different molecule-specific propensities to carry on the co-dependent deprotonation and redox processes. This study utilizes the known correlation between thiolate basicities and oxidizabilities, to quantify antioxidant or reducing capacities and pH-dependences of thiol–disulfide antioxidant systems, as a tool to find adequate m

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Uğur, Cüneyt, Hasan Madenci, Hüseyin Kurku, and Salim Neşelioğlu. "The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children." Journal of Pediatric Infectious Diseases 15, no. 04 (2020): 195–99. http://dx.doi.org/10.1055/s-0040-1709700.

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Abstract Objective The aim of this study was to determine the role of thiol/disulfide homeostasis (TDH) parameters which are new oxidative stress markers for the diagnosis of acute appendicitis (AA) in children with abdominal pain complaints. Methods A total of 40 patients with AA and 45 patients with abdominal pain were included in this study. Two groups were compared in terms of age, gender, white blood cell count, neutrophil-to-lymphocyte ratio, C-reactive protein (CRP), appendix diameter, and TDH parameters (native and total thiol levels, native thiol/total thiol ratio [antioxidant paramet

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Aksin, Şerif, and Mehmet Yilmaz. "The role of thiol/disulfide homeostasis in unexplained primary infertile patients: A prospective cohort study." Medicine 104, no. 9 (2025): e41641. https://doi.org/10.1097/md.0000000000041641.

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Background: Our study aims to investigate whether there is a relationship by measuring the total oxidant/antioxidant load with the thiol/disulfide method in patients with unexplained infertility. Methods: A total of 82 participants were enrolled, consisting of 41 women with unexplained infertility and 41 fertile controls matched for age and body mass index (BMI). Hormonal profiles, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), thyroid-stimulating hormone (TSH), and prolactin, were assessed using the chemiluminescence immunoassay method. Thiol/disulfide

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ERTAŞ, Fatma, Şemistan KIZILTEPE, and Oğuz MERHAN. "Investigation of Dynamic Thiol Disulfide Homeostasis in Young Cattle With Pneumonia." MAS Journal of Applied Sciences 8, Özel Sayı (2023): 949–54. https://doi.org/10.5281/zenodo.10003819.

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The aim of this study was to investigate blood levels of thiol and disulfide, a new oxidative stress marker of oxidant and antioxidant balance, or thiol/disulfide ratios in cattle diagnosed with pneumonia and to determine its usefulness as a new prognostic inflammatory marker. The animal material of the study consisted of 20 cattle diagnosed with pneumonia as a result of clinical examinations, aged between 01-02 years, male and female were not important. Total thiol, native thiol, disulfide levels and dynamic thiol disulfide balance were measured chlorometrically with a spectrophotometer. As a

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Tanyildiz, Murat, Ayse Filiz Yetimakman, Mutlu Uysal Yazici, et al. "Effect of cardiopulmonary bypass on thiol/disulfide homeostasis in congenital heart surgery." Turkish Journal of Thoracic and Cardiovascular Surgery 31, no. 4 (2023): 454–66. http://dx.doi.org/10.5606/tgkdc.dergisi.2023.25283.

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Background: This study aims to investigate whether thiol/disulfide homeostasis parameters measurements could be used as a new biomarker to predict the pre- and post-cardiopulmonary bypass oxidative status of pediatric patients undergoing congenital heart surgery. Methods: A total of 40 children with congenital heart disease (17 males, 23 females; mean age: 39.6±40.0 months; range, 2 to 216 months) who underwent open-heart surgery were included. The control group consisted of 40 age- and sex-matched healthy children (18 males, 22 females; mean age: 42.8±46.6 months; range, 12 to 156 months). Th

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Taskin, Seyhan, Hakim Celik, Seniz Demiryurek, and Abdullah Taskin. "THE BIDIRECTIONAL EFFECT OF CREATINE SUPPORTS THE MAINTENANCE OF OXIDANT-ANTIOXIDANT HOMEOSTASIS DURING EXERCISE." International Journal of Research -GRANTHAALAYAH 9, no. 10 (2021): 18–28. http://dx.doi.org/10.29121/granthaalayah.v9.i10.2021.4279.

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The importance of supplements used with exercise is increasing day by day. In this study, it was aimed to evaluate the effects of creatine monohydrate (CrM) supplementation with different intensities of exercise on oxidative stress through dynamic thiol disulfide homeostasis. Fourty two BALB/c mice were used and randomly divided into 6 groups; control (C), low-intensity exercise (LIE), high-intensity exercise (HIE), C+CrM (4% of daily diet), LIE+CrM, and HIE+CrM groups. Exercise groups were performed low-intensity (8m/min/30min/day) and high-intensity (24m/min/30min/day) exercise on a mouse tr

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Yüzbaşıoğlu, Yücel, Güllü Ercan Haydar, Yavuz Otal, et al. "Thiol–disulfide Homeostasis in Acute Appendicitis." Medical Journal of Islamic World Academy of Sciences 25, no. 4 (2017): 114–17. http://dx.doi.org/10.5505/ias.2017.78803.

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Tetikoğlu, Mehmet, Serdar Aktas, Haci Murat Sağdik, et al. "Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome." Current Eye Research 42, no. 6 (2017): 876–79. http://dx.doi.org/10.1080/02713683.2016.1256412.

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Yilmaz, Ömer Hınç, Ceylan Bal, Salim Neşelioglu, et al. "Thiol/disulfide homeostasis in asphalt workers." Archives of Environmental & Occupational Health 71, no. 5 (2016): 268–72. http://dx.doi.org/10.1080/19338244.2015.1076760.

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Kulaksizoglu, Burak, and Sibel Kulaksizoglu. "Thiol/Disulfide Homeostasis in Schizophrenic Patients." Neurochemical Journal 12, no. 1 (2018): 102–6. http://dx.doi.org/10.1134/s1819712418010075.

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Korkmaz, V., Z. Kurdoglu, M. Alisik, et al. "Thiol/disulfide homeostasis in postmenopausal osteoporosis." Journal of Endocrinological Investigation 40, no. 4 (2016): 431–35. http://dx.doi.org/10.1007/s40618-016-0585-7.

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Ergin, Merve, Cevdet Aydin, Emine Feyza Yurt, Bekir Cakir, and Ozcan Erel. "The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus." Experimental and Clinical Endocrinology & Diabetes 128, no. 02 (2018): 77–81. http://dx.doi.org/10.1055/s-0044-100376.

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Abstract Aim The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes mellitus. Methods This study included 32 subjects with known type 2 diabetes mellitus without complications, 30 patients with type 2 diabetes mellitus with complications, 28 newly diagnosed patients with type 2 diabetes mellitus, and 45 healthy individuals. Thiol-disulfide profile tests were quantified in all groups. Results Compared to the control group, patients in each of the diabetic groups had significantly lower native and total thiol levels, higher disulfide levels, and higher

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Gulpamuk, Bayram, Ufuk Elgin, Emine Sen, Pelin Yilmazbas, Salim Neselioglu, and Ozcan Erel. "Evaluation of dynamic thiol–disulfide homeostasis in glaucoma patients and the correlation with retinal nerve fiber layer analysis." European Journal of Ophthalmology 30, no. 4 (2019): 690–99. http://dx.doi.org/10.1177/1120672119839582.

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Purpose: The aim of this study was to evaluate thiol/disulfide homeostasis and ischemia-modified albumin levels with primary open-angle glaucoma, ocular hypertension, and control group; also to interpret the correlation between these biochemical parameters and retinal nerve fiber layer analysis. Material and methods: In a prospective cross-sectional study, 30 primary open-angle glaucoma cases, 30 ocular hypertension cases, and 30 control subjects were included in the study. Native thiol, total thiol, and disulfide measurements and disulfide/native thiol, disulfide/total thiol, and native thiol

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Bal, C., M. Büyükşekerci, C. Koca, et al. "The compromise of dynamic disulfide/thiol homeostasis as a biomarker of oxidative stress in trichloroethylene exposure." Human & Experimental Toxicology 35, no. 9 (2016): 915–20. http://dx.doi.org/10.1177/0960327115608928.

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In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measuring urinary trichloroacetic acid (TCA) concentration. Median urinary TCA levels of exposed workers (20.5 mg/L) were significantly higher than control subjects (5 mg/L). Thiol and disulfide concentrations were determined using a novel automated method. Disulfide/thiol ratio was signi

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Yilmaz, Cakmak, Emin Gemcioglu, Salih Baser, Sükran Erten, and Ozcan Erel. "Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome." Journal of Medical Biochemistry 40, no. 3 (2021): 270–76. http://dx.doi.org/10.5937/jomb0-27281.

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Background: Primary Sjögren's syndrome (pSS) is a disease associated with the overexpression of proinflammatory cytokines, and oxidative stress is one of the factors responsible for its etiopathogenesis. This study aimed to investigate the thiol/disulphide homeostasis in pSS patients. Methods: The study included 68 pSS patients and 69 healthy controls. Thiol/disulphide homeostasis (total thiol, native thiol, and disulphide levels) was measured using the automatic spectrophotometric method developed by Erel and Neselioglu, and the results of the 2 groups were compared. Results: The gender and a

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Yücel, Hilal. "Evaluation of dynamic thiol/disulphide homeostasis and ischemia-modified albumin levels in sudden sensorineural hearing loss." Praxis of Otorhinolaryngology 10, no. 3 (2022): 126–32. http://dx.doi.org/10.5606/kbbu.2022.28190.

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Objectives: This study aimed to investigate the role of ischemia-modified albumin and thiol/disulfide hemostasis in idiopathic sudden sensorineural hearing loss (ISSNHL). Patients and Methods: This prospective study was conducted with volunteers diagnosed with ISSNHL and healthy individuals between November 2018 and June 2019. The study group included 46 patients (27 males, 19 females; mean age: 42.4±12.3 years; range, 18 to 69 years), and the control group included 41 healthy individuals (25 males, 16 females; mean age: 37.8±11.7 years; range, 18 to 65 years). Serum thiol, disulfide, and isch

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Üstündağ Budak, Yasemin, Serdar Kahvecioğlu, Hüseyin Çelik, Murat Alışık, and Özcan Erel. "Serum Thiol/Disulfide Homeostasis in Hemodialysis, Peritoneal Dialysis, and Renal Transplantation Patients." Turkish Nephrology Dialysis Transplantation 26, no. 01 (2017): 105–10. http://dx.doi.org/10.5262/tndt.2017.1001.17.

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Dumlu, Ersin Gürkan, Mehmet Tokaç, Mustafa Özsoy, et al. "Determination of Dynamic Plasma Thiol -disulfide Homeostasis with a Novel Technique in Intestinal Ischemia Reperfusion Injury." European Journal of Clinical Medicine 2, no. 3 (2021): 55–59. http://dx.doi.org/10.24018/clinicmed.2021.2.3.83.

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Introduction: Intestinal ischemia/reperfusion (I/R) is a serious life-threatening clinical case. Overproduction of reactive oxygen species (ROS) associated with oxidative stress plays a key role in I/R pathophysiology. Objective: The aim of this study is to evaluate dynamic thiol / disulfide hemostasis in intestinal I/R in rats. Materials and Methods: 24 Winstar albino rats were divided into 3 groups (8 animals in each group: (1) sham (operation without ischemia), (2) ischemia (90 minutes ischemia), (3) ischemia/reperfusion (after ischemia for 30 minutes reperfusion for 60 minutes)

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Yoshioka, Jun. "Thioredoxin Superfamily and Its Effects on Cardiac Physiology and Pathology." Comprehensive Physiology 5, no. 2 (2015): 513–30. https://doi.org/10.1002/j.2040-4603.2015.tb00622.x.

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ABSTRACTA precise control of oxidation/reduction of protein thiols is essential for intact cardiac physiology. Irreversible oxidative modifications have been proposed to play a role in the pathogenesis of cardiovascular diseases. An imbalance of redox homeostasis with diminution of antioxidant capacities predisposes the heart to oxidant injury. There is growing interest in endoplasmic reticulum (ER) stress in the cardiovascular field, since perturbation of redox homeostasis in the ER is sufficient to cause ER stress. Because a number of human diseases are related to altered redox homeostasis a

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Yılmaz Deveci, Mehmet Zeki, and Hüseyin Erdal. "Determination of dynamic thiol-disulfide levels in dairy cattle with foot disease." Veterinarski arhiv 92, no. 6 (2023): 657–66. http://dx.doi.org/10.24099/vet.arhiv.1785.

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Foot diseases are among the top three causes of economic loss in dairy cattle. Recent studies show that oxidative stress plays a critical role in the pathogenesis of foot diseases. There is no study determining the dynamic thiol-disulfide levels in dairy cattle with foot disease. This study aimed to determine dynamic thiol-disulfide levels in foot diseased and healthy dairy cattle. Demographic information about the animals, and clinical findings of foot diseases and lameness were presented. In the Foot Disease Group, native thiol (P<0.01), total thiol (P<0.05), disulfide (P<0.01), dis

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Akhanl, P., Sema en, Hakan er, et al. "The Evaluation of Dynamic Thiol/Disulfide Homeostasis in Papillary Thyroid Carcinoma." Annals of Medical Research 30, no. 10 (2023): 1. http://dx.doi.org/10.5455/annalsmedres.2023.08.196.

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Objectives: Aim of this study is to analyze the correlation between thiol/disulfide homeostasis (TDH) and papillary thyroid carcinoma (PTCA) and to reveal the possible impact of TDH on the development of PTCA. Material and Methods: Preoperative venous blood sampling was obtained from the patients having applied to our hospital due to euthyroid nodular goiter and detected with suspected malignancy or malignant cytology in FNAB, according to the BETHESDA system. Those whose postoperative histopathological results proved the presence of PTCA were involved in this study. Healthy volunteers who wer

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Ozdemir, Ayse Z., Pervin Karlı, and Salim Neşeli̇oğlu. "Does thiol/disulfide homeostasis affect the number of metaphase 2 oocyte in the treatment of in vitro fertilization?" Future Science OA 6, no. 2 (2020): FSO452. http://dx.doi.org/10.2144/fsoa-2019-0132.

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Aim: To investigate the effect of thiol/disulfide homeostasis on the number of oocytes retrieved and metaphase 2 (M2) oocytes in patients undergoing in vitro fertilization. Method: A prospective study of 94 patients who were admitted to the in vitro fertilization clinic was conducted. Serum samples were taken on the oocyte pick-up day and kept until the analysis. Thiol and disulfide were measured in order to evaluate the total thiol/disulfide. Results: A statistically significant correlation was observed between disulfide and M2. Conclusion: This study provides an inexpensive and noninvasive m

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Akdogan, Muberra, Yasemin Ustundag, Arzu Akdağ, Salim Neselioglu, and Ozcan Erel. "The Thiol-Disulfide Homeostasis and Coenzyme Q10 in Conjunction with Vitamin E Effect on Retinopathy Prematurity." Open Ophthalmology Journal 13, no. 1 (2019): 23–28. http://dx.doi.org/10.2174/1874364101913010023.

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Purpose: This study was performed to determine whether one drop of topical administration of Coqun® (Coenzyme Q10 and Vitamin E)-a potent antioxidant-twice a day has any effect on the thiol-disulphide homeostasis-a novel oxidative stress marker in the Retinopathy Of Prematurity (ROP) disease course. Methods: This was a prospective observational study comprising 28 infants with ROP at stage 2 and higher who followed up at the paediatric intensive care unit. Ferric reducing power of plasma (FRAP), albumin, ischemia-modified albumin (IMA) and thiol disulphide homeostasis levels were studied in th

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Solak, Ibrahim, MehmetAli Eryilmaz, Betül Kozanhan, ÇigdemDamla Çetinkaya, Salim Neselioglu, and Özcan Erel. "Thiol-disulfide homeostasis in breast cancer patients." Journal of Cancer Research and Therapeutics 15, no. 5 (2019): 1062. http://dx.doi.org/10.4103/jcrt.jcrt_553_17.

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Alagöz, Aybala Neslihan, Nimet Uçaroğlu Can, Hayrullah Yazar, and Sıdıka Sinem Taşdemir. "Thiol-disulfide Homeostasis in Idiopathic Parkinson’s Disease." Kafkas Journal of Medical Sciences 10, no. 1 (2020): 39–45. http://dx.doi.org/10.5505/kjms.2020.03743.

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Korkmaz, Vakkas, Zehra Kurdoglu, Murat Alisik, et al. "Impairment of thiol-disulfide homeostasis in preeclampsia." Journal of Maternal-Fetal & Neonatal Medicine 29, no. 23 (2016): 3848–53. http://dx.doi.org/10.3109/14767058.2016.1149561.

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Ergin, M., B. D. Cendek, S. Neselioglu, A. F. Avsar, and O. Erel. "Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum." Journal of Perinatology 35, no. 10 (2015): 788–92. http://dx.doi.org/10.1038/jp.2015.81.

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Topcuoglu, Canan, Abdurrahim Bakirhan, Fatma Meric Yilmaz, Salim Neselioglu, Ozcan Erel, and Safak Yalcin Sahiner. "Thiol/disulfide homeostasis in untreated schizophrenia patients." Psychiatry Research 251 (May 2017): 212–16. http://dx.doi.org/10.1016/j.psychres.2017.02.016.

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