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Artykuły w czasopismach na temat „Tolerable analgesic”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Lukito, Johan Indra. "Kombinasi Analgesik Non-opioid Intravena untuk Tata Laksana Nyeri Akut." Cermin Dunia Kedokteran 50, no. 9 (2023): 509–15. http://dx.doi.org/10.55175/cdk.v50i9.868.

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Konsep analgesia multimodal dianjurkan untuk pengobatan nyeri. Paracetamol dan nonsteroidal antiinflammatory drugs (NSAID) umumnya menjadi analgesik dasar, serta dikombinasikan dengan opioid sesuai kebutuhan. Analgesik intravena (IV) dapat menjadi solusi bagi pasien yang tidak dapat menerima analgesik per oral. Kombinasi paracetamol dan ibuprofen IV menunjukkan efek analgesik yang signifikan, dengan manfaat opioid sparing, antipiretik, serta dengan profil keamanan yang relatif baik pada pasien nyeri akut. The concept of multimodal analgesia is recommended for the treatment of pain. Paracetamol

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C., Muraleemohan, Pratiksha Shetty, Satadru Roy, and B. Rajendra Prasad. "Opioids in the World of Oral and Maxillofacial Surgery- A Review." Journal of Health and Allied Sciences NU 08, no. 03 (2018): 029–33. http://dx.doi.org/10.1055/s-0040-1708760.

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AbstractPain control is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of Morphine by Friedrich Sertürner in 1804 added an essential pharmacological tool in the treatment of pain and spawned the discovery of a new class of drugs known collectively as Opioid analgesics. To date, Morphine and other opioids remain essential analgesics for alleviating pain. However, their use is plagued by major side effects, such as analgesic tolerance (diminished pain-relieving effects), hyperalgesia (increased pain sensitivity), and drug dependence. Despite

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Egbunike, Ifeanyi G., and Betty J. Chaffee. "Antidepressants in the Management of Chronic Pain Syndromes." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 10, no. 4 (1990): 262–70. http://dx.doi.org/10.1002/j.1875-9114.1990.tb02582.x.

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Conditions in which antidepressants have been used include diabetic neuropathy, postherpetic neuralgia, headaches, arthritis, chronic back pain, cancer, thalamic pain, facial pain, and phantom limb pain. Although much of the available information is derived from inadequately controlled trials, it seems that antidepressants provide analgesia in many of these disorders. The analgesic effects tend to be independent of antidepressant effects, and doses of heterocyclic antidepressants used for analgesia seem to be lower than those considered effective in the treatment of depression. Doses should be

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Fürst, Susanna, Zoltán S. Zádori, Ferenc Zádor, et al. "On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance." Molecules 25, no. 11 (2020): 2473. http://dx.doi.org/10.3390/molecules25112473.

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There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well recognized. Unfortunately, chronic treatment with opioid analgesics induces central analgesic tolerance, thus limiting their clinical usefulness. Numerous molecular mechanisms, including receptor desensitization, G-protein decoupling, β-arrestin recruitment, and alterations in the expression of peripheral MORs and microbiota have been postulated t

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Raymond, Stephen A., John F. Hutchin, Arnold Degboe, and Kenneth G. Faulkner. "Using oral morphine-equivalent values to track the analgesic effect of treatments in clinical trials." Journal of Clinical Oncology 38, no. 15_suppl (2020): e14075-e14075. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e14075.

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e14075 Background: Patient reported pain is subjective, requiring individuals to grade the feeling of pain as “high” or “low”, typically using a numeric scale. As a supplement to self-reported pain, monitoring the dosage and type of treatment needed to keep pain at a tolerable or comfortable level has been suggested. However, differences in treatments can complicate the ability to compare analgesic effects. One approach to this problem uses a 30 mg oral dose of morphine as a standard to quantify the relative analgesic strength of different pain medications. Methods: For use in clinical researc

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Nazia, Shaikh, Subhedar Rajesh, and Borse Yogesh. "A Comparative Study of Dexamethasone and Magnesium Sulphate as an Adjuvant to 0.5% Bupivacaine in Supraclavicular Brachial Plexus Block." International Journal of Pharmaceutical and Clinical Research 15, no. 4 (2023): 248–57. https://doi.org/10.5281/zenodo.12658854.

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<strong>Introduction:</strong> Upper extremity fractures are usually associated with marked postoperative pain. The goal of postoperative pain management is to reduce pain to a tolerable level with minimal or no associated suffering or distress. Brachial plexus block provides us with an alternative anaesthesia technique for upper limb surgeries that provides excellent surgical conditions and a prolonged duration of postoperative analgesia.  The addition of an adjuvant to a local anaesthetic solution has helped in the early onset of blockade with a prolonged duration of anaesthesia an

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Malas, Hosni, Stephanie Hsu, and Yasmin Mohammed. "Office Hysteroscopy: King Hamad University Hospital Experience." Journal of the Bahrain Medical Society 35, no. 1 (2023): 1–8. http://dx.doi.org/10.26715/jbms.35_1_1.

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Background & Objective: Office hysteroscopy (OH) is an efficient alternative for diagnosis and management of intrauterine pathology. The main goal of this study is to determine the usefulness and tolerability of OH in the patient population of a tertiary teaching hospital in the Kingdom of Bahrain. Methods: The total population consists of 101 patients who were prospectively included in the study from 2018 to 2020. The main indication for OH were abnormal uterine bleeding followed by post-menopausal bleeding. Results: The procedure was tolerable without analgesia in 93% of cases, analgesia

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Durairajan, Sheela, Preetha Selva, Rajagopalan Vijayaraghavan, Senthil Kumar Sivanesan, and Srinivasan Vengadassalaapathy. "Investigation on Reliability of Administering an Opioid Analgesic Through an Autoinjector by Exploring the Oxidative Stress Parameters in Albino Wistar rats." Biomedical and Pharmacology Journal 18, no. 2 (2025): 1479–88. https://doi.org/10.13005/bpj/3185.

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Modification in drug release provides efficient drug delivery for the benefit of the consumers in improving their convenience, compliance, safety, and efficacy. The need for self-administration of drugs has also evolved due to extreme conditions like natural and man-made disasters to reduce the malaise and fatality. The purpose of this research is to know the reliability of using an opioid analgesic through a self-injectable device during extremity conditions. The opioid analgesic used in this research was buprenorphine. This self-injectable analgesic autoinjector is a recyclable device with t

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Díaz, Mirelys Valladares, Taimilquis León Perón, and Annelis Pérez Rodríguez. "Morphine - bupivacaine and bupivacaine in gynecological surgeries." MOJ Surgery 10, no. 1 (2022): 26–29. http://dx.doi.org/10.15406/mojs.2022.10.00198.

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Objective: Evaluate the intrathecal use of morphine-bupivacaine and bupivacaine in gynecological surgeries. Material and methods: An analytic longitudinal prospective study was perfomed at the Manuel Piti Fajardo Hospital in Florida, from February 2019 to March 2020. The universe was compound by 180 patients. Sample was select about 60 patients by probabilistic simple randon sampling distributed in two groups: A (Morphine -Bupivacaine) and B (Bupivacaine) according to inclusion criteria. The data were collected in questionnaire properly to investigation with baseline data in Statistical Packag

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10

Taneja, Akshat, Akash Gupta, Malti Agrawal, Upasana Asooja, and Ashok Taneja. "A PROSPECTIVE RANDOMIZED STUDY TO EVALUATE THE ANALGESIC AND SEDATIVE EFFECTS OF FENTANYL AND MIDAZOLAM TO NALBUPHINE AND MIDAZOLAM IN PATIENTS UNDERGOING AWAKE FIBEROPTIC." International Journal of Advanced Research 9, no. 09 (2021): 530–38. http://dx.doi.org/10.21474/ijar01/13444.

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Background- Awake nasal or oral flexible fiberoptic intubation (AFOI) is technique of choice in known or anticipated difficult airway . The main aim was to have calm and cooperative patient who can follow verbal commands while maintaining adequate oxygenation . In our study, we compared the analgesic and sedative effects of fentanyl and midazolam with nalbuphine and midazolam in patients undergoing awake fiberoptic intubationmore tolerable and comfortable for the patient but also to ensure optimal intubating conditions. Material and Methodsâ€“ A prospective, randomized comparison study among p

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11

Ozdemir, Ercan. "The pathophysiological role of serotonin receptor systems in opioid analgesia and tolerance." International Journal of Basic & Clinical Pharmacology 6, no. 2 (2017): 217. http://dx.doi.org/10.18203/2319-2003.ijbcp20170312.

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Continuous treatment with opioid analgesics, such as morphine, leads to the development of ant nociceptive tolerance in patients. Although a lot of information about antinociceptive, the pathophysiological mechanisms of tolerance to opioid analgesia are not yet completely understood. Proposed mechanisms for opioid analgesic tolerance comprise down-regulation of opioid receptors, reduction of sensitivity G-proteins, altered intracellular signalling pathway including nitric oxide, adenyl cyclase, and protein kinase C. Numerous physiological and behavioural studies have shown an interaction of th

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12

Jovanovic, Nikola, Radan Dzodic, Aleksandar Celebic, Milan Zegarac, Igor Djurisic, and Dejan Stojiljkovic. "Treatment of post-operative pain in old oncology patients with intravenous application of 50% glucose solution." Srpski arhiv za celokupno lekarstvo 131, no. 1-2 (2003): 52–54. http://dx.doi.org/10.2298/sarh0302052j.

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Postoperative pain is the most important factor od so called "tumor promotive effect of surgery" ie. of endocrine-metabolic changes having the consequence drop in immune, antiinfective and antitumor defense. Due to presence of organic involutive changes, old people (? 65 years), often have serious side effects during application of usual analgetics. Since hypertonic glucose (33%) given i.v. or per os, works analgesically in small children there is assumption that it can be used in treatment of postoperative pain in old oncology patients. We tested the hypothesis that postoperative pain in old

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13

Smith, Howard. "Combination Opioid Analgesics." Pain Physician 2;11, no. 3;2 (2008): 201–14. http://dx.doi.org/10.36076/ppj.2008/11/201.

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Although there is no “ideal analgesic,” scientists and clinicians alike continue to search for compounds with qualities which may approach the “ideal analgesic.” Characteristics of an “ideal” analgesic may include: the agent is a full agonist providing optimal/maximal analgesia for a wide range/variety of pain states (e.g., broad spectrum analgesic activity), it does not exhibit tolerance, it produces no unwanted effects and minimal adverse effects, it has no addictive potential, it does not facilitate pain/hyperalgesia, it has a long duration, it has high oral bioavailability, it is not vulne

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Shen, Zhen, Yun-Dan Guo, Ming-Ze Tang, et al. "Dexborneol Amplifies Pregabalin’s Analgesic Effect in Mouse Models of Peripheral Nerve Injury and Incisional Pain." Antioxidants 13, no. 7 (2024): 803. http://dx.doi.org/10.3390/antiox13070803.

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Pregabalin is a medication primarily used in the treatment of neuropathic pain and anxiety disorders, owing to its gabapentinoid properties. Pregabalin monotherapy faces limitations due to its variable efficacy and dose-dependent adverse reactions. In this study, we conducted a comprehensive investigation into the potentiation of pregabalin’s analgesic effects by dexborneol, a neuroprotective bicyclic monoterpenoid compound. We performed animal experiments where pain models were induced using two methods: peripheral nerve injury, involving axotomy and ligation of the tibial and common peroneal

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Nibras Jamal, Ahmed Muthana, Nada Sahib, Zeena Ayad, Esraa Ghazy, and Mays Imad. "Nefopam induced dose-related changes in renal and hepatic functions." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 1312–17. http://dx.doi.org/10.26452/ijrps.v11i2.1987.

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Nefopam is a non-opioid, centrally acting, non-steroidal analgesic drug. It is used to treat mild to moderate painful conditions. Although developed about five decades ago, its use has gained resurgence in recent years. This study was designed to investigate the effects of different analgesic doses of nefopam on the liver and kidneys of mice. Forty albino mice were divided into four groups of 10 mice for each group. Group 1, 2 &3 received a daily intraperitoneal injection of Nefopam at 10, 20, and 30 mg/kg doses, respectively. The fourth group (control group) received injections of normal

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Solodyannikova, O., V. Danilenko, and G. Sukach. "ANALGESIC EFFECT OF VARIOUS RADIOPHARMACEUTICALS IN THE COMPLEX TREATMENT OF METASTATIC BONE DISEASE." Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 26 (2021): 562–72. http://dx.doi.org/10.33145/2304-8336-2021-26-562-572.

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Objective. The study objective was to investigate and compare the effectiveness of different radiopharmaceuticals in the treatment of metastatic bone disease. Materials and methods. Cancer patients (n = 150, average age (55 ± 11.6) years, 95 females, 55 males) having got various primary tumors and metastatic bone disease were given medical treatment at the Department of Nuclear Medicine of the National Institute of Cancer. The 153Sm, 32Р, and 89Sr radiopharmaceutical agents produced by the «Radiopreparats» enterprise (Republic of Uzbekistan) and Radioisotope Centre Polatom (National Centre for

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Drozdov, V. N., E. V. Shikh, S. Y. Serebrova, A. G. Abrosimov, and A. K. Starodubtsev. "Alflutop - in modern symptom - modifying osteoarthritis therapy." Terapevticheskii arkhiv 91, no. 5 (2019): 134–40. http://dx.doi.org/10.26442/00403660.2019.05.000169.

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One of the serious problems during the treatment of osteoarthritis (OA) is the developing of adverse drug events during therapy. Nonsteroidal anti - inflammatory drugs (NSAIDs) are the first drugs with the high incidence and severity of adverse events. This article describes OA treatment strategies approaches for OA are presented using the complex drug Alflutop, which has a composition similar to the human hyaline cartilage. The drug has anti - inflammatory and analgesic effects, normalizes the function of the affected joints, improves the quality of patients’ life, also has a structure - modi

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Lugito, Manuel Dwiyanto Hardjo. "FIXED DOSE COMBINATION OF MECOBALAMIN AND PREGABALIN IN THE TREATMENT OF OROFACIAL NEUROPATHIC PAIN." Interdental Jurnal Kedokteran Gigi (IJKG) 20, no. 1 (2024): 170–75. http://dx.doi.org/10.46862/interdental.v20i1.8570.

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Introduction: orofacial neuropathic pain is extraordinary disease in character with its complicated management. Mecobalamin has been used to provide regeneration of traumatized nerves. Pregabalin with its analgesic activities relieves the clinical signs of neuropathic pain. The aim of this case report is to explain fixed dose combination of Mecobalamin and Pregabalin as the treatment of neuropathic pain caused by inferior alveolar nerve and facial nerve neuropathy. Case: First case was an inferior alveolar nerve neuropathy experienced by 63 years old female with complaints of persistent pain a

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Smith, Howard S. "Opioids and Neuropathic Pain." July 2012 3S;15, no. 3S;7 (2012): ES93—ES110. http://dx.doi.org/10.36076/ppj.2012/15/es93.

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Opioids are broad spectrum analgesics that may be beneficial to alleviate the intense perception of algesia in patients suffering with pain. They have been one of the most controversial analgesics, in part because of their potential for addiction. Opioids or any currently available analgesic will not provide effective analgesia for every patient with chronic neuropathic pain (NP), but overall opioids are considered to be a second or third line class of analgesics that may provide reasonable analgesia to some patients with chronic NP. Although opioids may alleviate chronic NP, overall, NP tends

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Al Maruf, Abdullah, Iqbal Hosain Chowdhury, Kazi Ashkar Lateef, Manzoorul Haq Laskar, and Md Mustafa Kamal. "Epidural administration of ketamine or fentanyl with bupivacaine for postoperative analgesia A comparative study." Journal of the Bangladesh Society of Anaesthesiologists 22, no. 1 (2014): 21–25. http://dx.doi.org/10.3329/jbsa.v22i1.18097.

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The purpose of the study was to compare the analgesic effectiveness of epidural administration of ketamine mixed bupivacaine with fentanyl mixed bupivacaine in the management of postoperative pain. This prospective study was carried out in CMH, Bogra in one calendar year from July 2004 to June 2005. For postoperative pain management 100 patients of both sex, age ranging between 20 to 50 years, ASA physical status I and II scheduled for lower abdominal, pelvic and inguinal surgery were included in the study. All patients were divided into two groups. Epidural catheter was inserted in each patie

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Clarke, Stephen, Belinda E. Butcher, Andrew J. McLachlan та ін. "Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain". PLOS ONE 17, № 10 (2022): e0270543. http://dx.doi.org/10.1371/journal.pone.0270543.

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This pilot study aimed to assess the safety, tolerability, pharmacokinetics and exploratory analgesic effect of a novel water-soluble oro-buccal nanoparticle spray of a cannabis-based medicine (MDCNS-01) in patients with advanced incurable malignancy with unrelieved pain from opioid analgesic. The study was a non-blinded single arm 2 stage study. Stage I was a single escalating dose (n = 5) [2.5 mg Δ9-THC and 2.5 mg CBD) versus a 3-fold escalated dose. Stage II was an up-titrated dose in patients with advanced cancers and intractable pain (n = 25). During Stage I with an increased cannabis-bas

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Ettlin, Dominik A., Nenad Lukic, Jetmir Abazi, Sonja Widmayer, and Michael L. Meier. "Tracking local anesthetic effects using a novel perceptual reference approach." Journal of Neurophysiology 115, no. 3 (2016): 1730–34. http://dx.doi.org/10.1152/jn.00917.2015.

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Drug effects of loco-regional anesthetics are commonly measured by unidimensional pain rating scales. These scales require subjects to transform their perceptual correlates of stimulus intensities onto a visual, verbal, or numerical construct that uses a unitless cognitive reference frame. The conceptual understanding and execution of this magnitude estimation task may vary among individuals and populations. To circumvent inherent shortcomings of conventional experimental pain scales, this study used a novel perceptual reference approach to track subjective sensory perceptions during onset of

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Ferreira-Dos-Santos, Guilherme, David Cordeiro Sousa, João Costa, and António Vaz-Carneiro. "Análise da Revisão Cochrane: Pregabalina no Tratamento da Dor Crónica Moderada a Grave em Adultos com Fibromialgia. Cochrane Database Syst Rev. 2016;9:CD011790 e 2016;4:CD009002." Acta Médica Portuguesa 31, no. 7-8 (2018): 376. http://dx.doi.org/10.20344/amp.10433.

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Fibromyalgia can be clinically defined by widespread pain lasting for longer than 3 months with tenderness on palpation in 11 or more of 18 specified tender points. Many people with fibromyalgia are significantly disabled, and experience moderate to severe pain for many years, for which conventional analgesics are usually not effective. For these patients treatment options generally include antidepressants like tricyclic agents, serotonin and noradrenaline reuptake inhibitors, or anticonvulsants like pregabalin or gabapentin. Pregabalin is a drug licensed for the treatment of fibromyalgia in t

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Bull, Fiona A., Daniel T. Baptista-Hon, Claire Sneddon, Lisa Wright, Wendy Walwyn, and Tim G. Hales. "Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation." Anesthesiology 127, no. 5 (2017): 878–89. http://dx.doi.org/10.1097/aln.0000000000001834.

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Abstract Background Prolonged opioid administration leads to tolerance characterized by reduced analgesic potency. Pain management is additionally compromised by the hedonic effects of opioids, the cause of their misuse. The multifunctional protein β-arrestin2 regulates the hedonic effects of morphine and participates in tolerance. These actions might reflect µ opioid receptor up-regulation through reduced endocytosis. β-Arrestin2 also recruits kinases to µ receptors. We explored the role of Src kinase in morphine analgesic tolerance, locomotor stimulation, and reinforcement in C57BL/6 mice. M

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Sarmanayeva, R. R., G. R. Abuzarova, N. M. Bychkova, V. E. Khoronenko, and S. V. Kuznetcov. "The possibilities of using xenon therapy in patients with severe cancer pain." Meditsinskiy sovet = Medical Council, no. 9 (July 30, 2020): 265–70. http://dx.doi.org/10.21518/2079-701x-2020-9-265-270.

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In accordance with the clinical recommendations of the World Health Organization and the Ministry of Health of the Russian Federation, the main analgesics for the treatment of chronic cancer pain are non-opioid and opioid analgesics, given stepwise in combination with co-analgesics and adjuvant drugs. As a rule, this stepwise scheme of painkilling is effective in most cases. However, 20-30% of patients cannot achieve an acceptable level of pain relief despite the use of these analgesics in combination. Is there another way to help such patients? Interventional methods of analgesia are an optio

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Dawson, Cecilia, Daqing Ma, Andre Chow, and Mervyn Maze. "Dexmedetomidine Enhances Analgesic Action of Nitrous Oxide." Anesthesiology 100, no. 4 (2004): 894–904. http://dx.doi.org/10.1097/00000542-200404000-00020.

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Background Nitrous oxide and dexmedetomidine are thought to mediate analgesia (antinociception in a noncommunicative organism) via alpha 2B- and alpha 2A-adrenergic receptor subtypes within the spinal cord, respectively. Nitrous oxide and dexmedetomidine exert diametrically opposite effects on neuronal activity within the locus ceruleus, a pivotal site for modulation of analgesia. Because of these differences, the authors explored whether the two analgesics in combination would provide satisfactory analgesia. Methods The analgesic effects of nitrous oxide and dexmedetomidine given both intrape

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Augustinsson, Annelie, Elisabeth Franze, Martina Almqvist, Margareta Warrén Stomberg, Carina Sjöberg, and Pether Jildenstål. "Red-Haired People’s Altered Responsiveness to Pain, Analgesics, and Hypnotics: Myth or Fact?—A Narrative Review." Journal of Personalized Medicine 14, no. 6 (2024): 583. http://dx.doi.org/10.3390/jpm14060583.

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Red hair has been linked to altered sensitivity to pain, analgesics, and hypnotics. This alteration may be impacted by variants in the melanocortin-1 receptor (MC1R) gene, which are mainly found in redheads. The aim of this narrative review was to explore and present the current state of knowledge on red hair and its plausible associations with altered responsiveness to pain, analgesics, and hypnotics. Structured searches in the PubMed, CINAHL Complete, and Scopus electronic databases were conducted. Evidence suggests that women with red hair have an increased sensitivity to pain. Conversely,

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Basnet, A., S. Butler, P. Hartvig Honoré, et al. "Promising effects of donepezil when added to patients treated with gabapentin for neuropathic pain." Scandinavian Journal of Pain 4, no. 4 (2013): 257. http://dx.doi.org/10.1016/j.sjpain.2013.07.008.

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Abstract Aims The clinical relevance of adding the acetylcholinesterase inhibitor donepezil to existing gabapentin treatment in patients with post-traumatic neuropathic pain was explored in this open-label study. The two drugs have previously shown synergism following co-administration in nerve-injured rats [1,2]. Methods The study comprised two consecutive periods of minimum six weeks: (1) titration of gabapentin until highest tolerable dose or maximum 24GG mg daily; and (2) addition of donepezil 5 mg once daily to the fixed gabapentin dose. Efficacy and tolerability were assessed by ratings

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Sanjay, Parashar, Kumar Saxena Pradeep, Pathak Akshat, and Gupta Hemlata. "Comparative Study of the Stone Expulsion Rate after Treatment with Tamsulosin,Tadalafil and Combination of Tamsulosin and Tadalafil." International Journal of Toxicological and Pharmacological Research 13, no. 7 (2023): 253–60. https://doi.org/10.5281/zenodo.11115497.

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<strong>Objective: </strong>To compare the stone expulsion rate after treatment with tamsulosin, tadalafil and combination of tamsulosin and tadalafil. , the spontaneous passage of stones, the stone expulsion time, episodes of pain and analgesic dose required and side effects of drugs were noted and compared. <strong>Methods: </strong>Study is a hospital-based observational study conducted over a period of 18 months Patients aged ≥18 years presenting with solitary, symptomatic ureteral stone, size of 5-10 mm were grouped into three equal drug groups. Patients was advised drug

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Alhassen, Lamees, Khawla Nuseir, Allyssa Ha, et al. "The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence." Pharmaceuticals 14, no. 10 (2021): 1034. http://dx.doi.org/10.3390/ph14101034.

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The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction. A possible way to overcome this conundrum consists of a co-medication that maintains the analgesic benefits of opioids while preventing their adverse liabilities. YHS, the extract of the plant Corydalis yanhusuo, has been used as analgesic in traditional Chinese medicine for centuries. More recently, it has been shown to promote analgesia in animal models of acute, in

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Rijsdijk, Mienke, Camilla I. Svensson, Albert J. van Wijck, Cornelis J. Kalkman, and Tony L. Yaksh. "Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models." Scandinavian Journal of Pain 10, no. 1 (2016): 90–102. http://dx.doi.org/10.1016/j.sjpain.2015.10.006.

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AbstractBackground and aimGlucocorticoids, a group of anti-inflammatory agents, are frequently administered in pain medicine. Of interest is the reported activity after intrathecal delivery in patients with neuropathic pain syndromes such as postherpetic neuralgia, though its efficacy is controversial. After the publication of two randomized clinical trials in postherpetic neuralgia patients treated with similar intrathecal methylprednisolone acetate (MPA) dosing regimes with conflicting results; one showing significant pain reduction (Kotani N, Kushikata T, Hashimoto H, Kimura F, Muraoka M, Y

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Chen, Scott A., and Anthony L. Vaccarino. "Tolerance to Morphine Analgesia: Influence of Pain and Method of Morphine Delivery." Pain Research and Management 5, no. 4 (2000): 279–85. http://dx.doi.org/10.1155/2000/842034.

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Whether some kinds of pain can modify the development of tolerance to morphine analgesia is a controversial issue. Clinically, the development of tolerance is often difficult to establish because many factors can contribute to a decline in analgesic coverage, including disease progression. Basic animal research designed to examine tolerance provides the experimental control necessary to differentiate 'real' tolerance from other variables that can influence morphine analgesia. The present study examines the effects of inflammation induced by complete Freund's adjuvant (CFA) on the development o

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Zeng, Yen-Jing, Shih-Ying Tsai, Kuen-Bao Chen, Sheng-Feng Hsu, Julia Yi-Ru Chen, and Yeong-Ray Wen. "Comparison of Electroacupuncture and Morphine-Mediated Analgesic Patterns in a Plantar Incision-Induced Pain Model." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/659343.

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Electroacupuncture (EA) is a complementary therapy to improve morphine analgesia for postoperative pain, but underlying mechanism is not well-known. Herein, we investigated EA-induced analgesic effect in a plantar incision (PI) model in male Sprague-Dawley rats. PI was performed at the left hind paw. EA of 4 Hz and high intensity or sham needling was conducted at right ST36 prior to PI and repeated for another 2 days. Behavioral responses to mechanical and thermal stimuli, spinal phospho-ERK, and Fos expression were all analyzed. In additional groups, naloxone and morphine were administered to

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Kolesnikov, Yu A. "Сentral and peripheral mechanisms of mu-opioid analgesia and tolerance". Messenger of ANESTHESIOLOGY AND RESUSCITATION 16, № 1 (2020): 9–20. http://dx.doi.org/10.21292/2078-5658-2020-16-1-9-20.

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Objective – An analysis of the basic science and clinical publications found in PubMed, Medline, and Web of Science. The search covered modern laboratory and clinical mechanisms of peripheral mu opioid analgesia, the role of peripheral mu receptors in systemic analgesia and the development of tolerance to the analgesic effect of opioids. The review discusses the regulatory mechanisms of synthesis and transport of mu-opioid receptors in the primary afferent neurons and the molecular mechanisms responsible for modulating the conduction of nociceptive information from the periphery to the spinal

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Miura, Noriyoshi, Nozomu Tanji, Yutaka Yanagihara, et al. "Low-Dose Docetaxel Combined with Dexamethasone Is Feasible for Patients with Castration-Resistant Prostate Cancer." Chemotherapy 61, no. 1 (2015): 23–31. http://dx.doi.org/10.1159/000440942.

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Aim: Docetaxel-based chemotherapy against castration-resistant prostate cancer (CRPC) has recently been shown to be effective and tolerable. The objective of this study was to retrospectively evaluate the efficacy and toxicity of low-dose docetaxel in combination with dexamethasone. Methods: Thirty-seven CRPC patients were administered a treatment regimen consisting of 50 mg/m2 docetaxel once every 3-4 weeks and 1 mg dexamethasone daily at our institution, between November 2004 and April 2014. Results: Twenty-four patients (65%) had a decrease in serum prostate-specific antigen (PSA) >50%.

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Bryant, Camron D., Shoshana Eitan, Kevin Sinchak, Michael S. Fanselow, and Christopher J. Evans. "NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 291, no. 2 (2006): R315—R326. http://dx.doi.org/10.1152/ajpregu.00831.2005.

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Multiple studies demonstrate that coadministration of N-methyl-d-aspartate (NMDA) receptor antagonists with the opioid agonist morphine attenuates the development of analgesic tolerance. Sex differences in the effects of noncompetitive, but not competitive NMDA receptor antagonists on acute morphine analgesia, have been reported in mice, yet the role of sex in modulation of morphine tolerance by NMDA receptor antagonists has yet to be addressed. Therefore, we tested whether there is a sex difference in the effect of NMDA receptor antagonists on the development of morphine analgesic tolerance i

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Richebé, Philippe, Cyril Rivat, Jean-Paul Laulin, Pierre Maurette, and Guy Simonnet. "Ketamine Improves the Management of Exaggerated Postoperative Pain Observed in Perioperative Fentanyl-treated Rats." Anesthesiology 102, no. 2 (2005): 421–28. http://dx.doi.org/10.1097/00000542-200502000-00028.

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Background Although opioids are unsurpassed analgesics, experimental and clinical studies suggest that opioids activate N-methyl-d-aspartate pronociceptive systems leading to pain hypersensitivity and short-term tolerance. Because it is difficult in humans to differentiate pain from hyperalgesia during the postoperative period, the authors performed experimental studies with fentanyl using the rat incisional pain model for evaluating relations between hyperalgesia and short-term tolerance. Because N-methyl-d-aspartate receptor antagonists oppose both pain hypersensitivity and tolerance induced

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Roohbakhsh, Ali, Mohaddeseh Sadat Alavi, and Hassan Azhdari-Zarmehri. "The Orexinergic (Hypocretin) System and Nociception: An Update to Supraspinal Mechanisms." Current Medicinal Chemistry 25, no. 32 (2018): 3917–29. http://dx.doi.org/10.2174/0929867324666170529072554.

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Chronic pain is a multifaceted and complex condition that is divided into somatic, visceral, and neuropathic pain. Although opioids and nonsteroidal anti-inflammatory drugs cause analgesia and are effective in the treatment of chronic pain, their utility is hampered by side effects, abuse potential, and development of tolerance to their pain-relieving effects. So, finding alternative analgesics with good efficacy and low side effects is of great interest and the orexinergic system is a potential candidate. Orexin-A and -B are exclusively expressed in the lateral hypothalamus and are involved i

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Larochelle, MD, MPH, Marc R., Noelle M. Cocoros, DSc, MPH, Jennifer Popovic, DVM, MA, et al. "Opioid tolerance and urine drug testing among initiates of extended-release or long-acting opioids in Food and Drug Administration's Sentinel System." Journal of Opioid Management 13, no. 5 (2017): 315. http://dx.doi.org/10.5055/jom.2017.0407.

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Objective: A risk evaluation and mitigation strategy for extended-release and long-acting (ER/LA) opioid analgesics was approved by the Food and Drug Administration in 2012. Our objective was to assess frequency of opioid tolerance and urine drug testing for individuals initiating ER/LA opioid analgesics.Design: Retrospective cohort study.Setting: Sentinel, a distributed database with electronic healthcare data on >190 million predominantly commercially insured members.Patients, participants: Members under age 65 initiating ER/LA opioid analgesics between January 2009 and December 2013.Main

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Pham, Minh Quang, Anh Xuan Nguyen, and Thi Thu Phuong Tran. "Bilateral superficial cervical plexus block improves pain control after thyroidectomy under general anesthesia: a randomized, double-blind, clinical trial." Anaesthesia, Pain & Intensive Care 27, no. 2 (2023): 214–19. http://dx.doi.org/10.35975/apic.v27i2.2185.

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Background: Thyroidectomy is a surgical procedure that causes mild to moderate pain after surgery, which needs adequate management. Various pain control regimens have been used for this purpose including narcotic analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) and regional techniques. We studied the efficacy of bilateral superficial cervical plexus blocks (SCPB) under ultrasound guidance on post-operative pain after thyroidectomy under general anesthesia. Methodology: This randomized double-blind clinical controlled trial was conducted on sixty patients, who were randomly allocated

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Ng, Tony Kwun-Tung, Jui-An Lin, and Sumire Sasaki. "A Preliminary Analysis of a Modified Anterior Approach to Hip Pericapsular Neurolysis for Inoperable Hip Fracture Using the IDEAL Framework." Healthcare 10, no. 6 (2022): 1002. http://dx.doi.org/10.3390/healthcare10061002.

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Introduction: With an increasingly ageing population, there is a growing impact of fragility hip fracture on the healthcare system and on society as a whole. Oral and injectable analgesics are often insufficient whilst traction and regional blocks do not allow patients to be discharged easily. While the conventional approach of ultrasound-guided anterior hip pericapsular neurolysis can help a lot of inoperable hip fracture patients to relieve their fracture pain and facilitate subsequent nursing care, enormous technical challenges are encountered in some cases. In this retrospective case study

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Ozdemir, Ercan, Ihsan Bagcivan, Nedim Durmus, Ahmet Altun, and Sinan Gursoy. "The nitric oxide–cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine." Canadian Journal of Physiology and Pharmacology 89, no. 2 (2011): 89–95. http://dx.doi.org/10.1139/y10-109.

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Although the phenomenon of opioid tolerance has been widely investigated, neither opioid nor nonopioid mechanisms are completely understood. The aim of the present study was to investigate the role of the nitric oxide (NO)–cyclic guanosine monophosphate (cGMP) pathway in the development of morphine-induced analgesia tolerance. The study was carried out on male Wistar albino rats (weighing 180–210 g; n = 126). To develop morphine tolerance, animals were given morphine (50 mg/kg; s.c.) once daily for 3 days. After the last dose of morphine was injected on day 4, morphine tolerance was evaluated.

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Patarica-Huber, Erzebet, and Nedeljka Boskov. "Hurdles in successful treatment of cancer pain caused by primary healthcare." Archive of Oncology 18, no. 3 (2010): 65–70. http://dx.doi.org/10.2298/aoo1003065p.

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Background: The aim of this study is to envisage the hurdles set by physicians in primary healthcare that can cause, or contribute to unsatisfactory cancer pain management. Methods: The study has been carried out as a prospective open non-randomized one (based on a questionnaire). It comprised 283 physicians in primary healthcare from 21 institutions of primary healthcare in Serbia. The choice of physicians was done at random, and the completion of questionnaires was voluntary. The questionnaire comprised 12 questions. Among other issues the questions covered the most important characteristics

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Mantovani, Lorenzo G. "Valutazione farmacoeconomica dell’uso di tramadolo vs ketorolac nella gestione del dolore postoperatorio." Farmeconomia. Health economics and therapeutic pathways 4, no. 1 (2003): 11–16. http://dx.doi.org/10.7175/fe.v4i1.760.

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This article represents the first evaluation that compares the economic consequences of managing postsurgical pain with tramadol or ketorolac in the Italian setting. The economic evaluation was based on 5 clinical trials that directly compared the efficacy and tolerability of tramadol and ketorolac treatments in different settings and that contained drug consumption data. Since the review of these data confirmed that their efficacy is comparable (tramadol showed a quicker onset of the analgesic action, which was not considered for the purposes of the economic evaluation), it was chosen to cond

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Hsu, Yung-Wei, Jacques Somma, Yu-Chun Hung, Pei-Shan Tsai, Chen-Hsien Yang, and Chien-Chuan Chen. "Predicting Postoperative Pain by Preoperative Pressure Pain Assessment." Anesthesiology 103, no. 3 (2005): 613–18. http://dx.doi.org/10.1097/00000542-200509000-00026.

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Background The goal of this study was to evaluate whether preoperative pressure pain sensitivity testing is predictive of postoperative surgical pain. Methods Female subjects undergoing lower abdominal gynecologic surgery were studied. A pressure algometer was used preoperatively to determine the pressure pain threshold and tolerance. A visual analog scale (VAS) was used to assess postoperative pain. A State-Trait Anxiety Inventory was used to assess patients' anxiety. Subjects received intravenous patient-controlled analgesia for postoperative pain control. The preoperative pain threshold and

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Olofsen, Erik, Raymonda Romberg, Hans Bijl, et al. "Alfentanil and Placebo Analgesia." Anesthesiology 103, no. 1 (2005): 130–39. http://dx.doi.org/10.1097/00000542-200507000-00020.

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Background To assess whether patient sex contributes to the interindividual variability in alfentanil analgesic sensitivity, the authors compared male and female subjects for pain sensitivity after alfentanil using a pharmacokinetic-pharmacodynamic modeling approach. Methods Healthy volunteers received a 30-min alfentanil or placebo infusion on two occasions. Analgesia was measured during the subsequent 6 h by assaying tolerance to transcutaneous electrical stimulation (eight men and eight women) of increasing intensity or using visual analog scale scores during treatment with noxious thermal

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Hayashi, Yukio, Tian-Zhi Guo та Mervyn Maze. "Desensitization to the Behavioral Effects of α2-Adrenergic Agonists in Rats". Anesthesiology 82, № 4 (1995): 954–62. http://dx.doi.org/10.1097/00000542-199504000-00019.

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Background The analgesic and sedative-hypnotic utility of the alpha 2 agonists clonidine and dexmedetomidine are currently being investigated. Both compounds exert their behavioral responses by activating central alpha 2 adrenoceptors, albeit with different selectivities and efficacies. Furthermore, the analgesic and hypnotic behavioral responses are produced at different sites and may be affected independently of one another. A series of studies was conducted in rats to determine (1) whether tolerance and cross-tolerance develop to the analgesic actions of clonidine or dexmedetomidine; (2) ho

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Clarke, Stephen John, Luis Vitetta, Andrew J. McLachlan, Jeremy David Henson, David Rutolo, and Sean Hall. "An oro-buccal nanoparticle delivered cannabis medicine for pain management in cancer: A clinical trial in progress." Journal of Clinical Oncology 38, no. 15_suppl (2020): TPS12127. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.tps12127.

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TPS12127 Background: Cannabinoid molecules derived from Cannabis sativa L. have been posited to ameliorate conditions, including pain, chemotherapy induced nausea and multiple sclerosis associated spasticity. The clinical use of cannabinoids refers to a wide variety of formulations and extracts that may contain different active ingredients and adulterants as well as inter batch variability. Novel matrix formulations (e.g., water-soluble nanoparticles) for cannabis delivery may add further efficacy and tolerability to standard routes of administration (e.g., oral / gastrointestinal, inhaled, su

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Tikuišis, Renatas, Povilas Miliauskas, Narimantas Evaldas Samalavičius, and Giedrė Rudinskaitė. "Epidurinės nejautros poveikis skausmo malšinimui ir žarnyno funkcijos atsitaisymui po gaubtinės ir tiesiosios žarnos rezekcijos." Lietuvos chirurgija 6, no. 3 (2008): 0. http://dx.doi.org/10.15388/lietchirur.2008.3.2152.

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Renatas Tikuišis, Povilas Miliauskas, Narimantas Evaldas Samalavičius, Giedrė RudinskaitėVilniaus universiteto Onkologijos institutas, Santariškių g. 1, LT-08660 VilniusEl paštas: renatas.tikuisis@loc.lt Įvadas / tikslas Palyginti su sistemine analgezija opiatais, atliekant atviras gaubtinės ir tiesiosios žarnos operacijas, epidurinė nejautra efektyviau malšina skausmą ir ją sukėlus sumažėja pooperacinio žarnų nepraeinamumo dažnis. Šio tyrimo tikslas – nustatyti epidurinės analgezijos poveikį skausmo malšinimui ir žarnyno funkcijos atsitaisymui po gaubtinės ir tiesiosios žarnos operacijų. Ligo

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Paul, Alok K., Nuri Gueven, and Nikolas Dietis. "Profiling the Effects of Repetitive Morphine Administration on Motor Behavior in Rats." Molecules 26, no. 14 (2021): 4355. http://dx.doi.org/10.3390/molecules26144355.

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Efficient repetitive clinical use of morphine is limited by its numerous side effects, whereas analgesic tolerance necessitates subsequent increases in morphine dose to achieve adequate levels of analgesia. While many studies focused on analgesic tolerance, the effect of morphine dosing on non-analgesic effects has been overlooked. This study aimed to characterize morphine-induced behavior and the development and progression of morphine-induced behavioral tolerance. Adult male Sprague–Dawley rats were repetitively treated with subcutaneous morphine for 14 days in two dose groups (A: 5 mg/kg/da

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