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Rozprawy doktorskie na temat „Toxic factors”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Sullivan, Derek J. "Regulation of #alpha#-haemolysin gene expression in Staphylococcus aureus." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287423.

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Tonk, L. "Impact of environmental factors on toxic and bioactive peptide production by harmful cyanobacteria." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/51378.

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Dawson, Gabriel M. "Relationship Between Factors Associated with Toxic Stress and Child Behavior in the Dental Office." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469537364.

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Hargus, Emily Ann. "Toxic thoughts : Vulnerability factors and cognitive processes of thoughts or acts of deliberate self harm." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531819.

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Acamovic, Thomas. "Analysis, and nutritional evaluation for young chicks, of some toxic factors in three novel legumes." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/26168.

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Two tropical legumes and a temperate legume were studied during the course of this work. These were Leucaena leucocephala (cv. Peru), Canavalia ensiformis(cv. unknown) and Lupinus albus (cv. Vladimir [Kievskji mutant]) respectively. The dried ground leaf obtained from Leucaena leucocephala (LLM), the seeds of Canavalia ensiformis (jack bean; JB) and Lupinus albus (lupin) were the materials used in the study. Liquid chromatographic methods (HPLC) were developed for the analysis of mimosine and 3-hydroxy-4(lH )-pyridone (3,4-DHP) in LLM, Leucaena seed (LS) and chick excreta. Neither mimosine nor

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6

McCulley, B. Eric. "Factors Affecting the Toxic Cyanobacteria Nodularia Spumigena in Farmington Bay of Great Salt Lake, Utah." DigitalCommons@USU, 2014. https://digitalcommons.usu.edu/etd/4014.

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Farmington Bay of Great Salt Lake receives a significant amount of the nutrient-polluted runoff from Salt Lake and Davis Counties, Utah. This nutrient-laden runoff has led to seasonal blooms of blue-green algae, Nodularia spumigena, which produce a toxin called nodularin that has been shown to be toxic to aquatic organisms, birds, and mammals. Nodularia spumigena are the most common algae found in Farmington Bay. This study focused on understanding the physical and chemical factors controlling the growth of Nodularia spumigena in order to improve our knowledge about how nutrients impact algae

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Muñoz, Ramos Valentina. "Relationship between toxic cyanobacterial blooms, physico-chemical factors and multiple source excreta contamination in affected watershed." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117190.

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Missisquoi Bay (MB) is a temperate eutrophic freshwater ecosystem located in an agricultural watershed and it frequently experiences toxic Microcystis-dominated cyanobacterial blooms. Cyanobacterial population dynamics are influenced by a plethora of factors that may differ from system to system, requiring a site-specific assessment of bloom-promoting factors to design more effective bloom prevention or remediation strategies. This is the first biomonitoring study that combined data from high-throughput 16S rRNA gene amplicon sequencing, qPCR and environmental parameters from temporal and spat

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8

Okolo, Bartholomew Ndubuisi. "Alcohol tolerance in yeast : on factors influencing the inhibitory and toxic effects of alcohols on distilling yeast." Thesis, University of Strathclyde, 1986. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24267.

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An investigation of the factors influencing the inhibitory and toxic effects of ethanol and higher alcohols, byproducts of alcoholic fermentation, on yeast, is presented. The relative potency of alcohols was found to correlate strongly with the carbon chain-length or molecular size and the lipid solubility of the respective alcohols. Higher alcohols act synergistically with each other and with ethanol in causing cell death of suspensions of non-growing Saccharomyces cerevisiae. The presence of higher alcohols in fermented broth, even at low concentrations, and other by-products of alcoholic fe

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9

Ovesen, Jerald Lee. "Aryl Hydrocarbon Receptor Ligands of Widely Different Toxic Equivalency Factors Induce Similar Histone Marks in Target Gene Chromatin." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291408173.

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10

Ястремська, Лариса Сергіївна, І. Прекрасна, О. Таширев, and г. Снєгур. "Resistance of Negev desert microbial community to Cu2+ and Hg2+." Thesis, National Aviation University, 2013. http://er.nau.edu.ua/handle/NAU/38607.

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The aim of the work is to evaluate the ability to keep stabile functioning of microbial community of Negev Desert clay (Israel) in the presence of typical for damaging effect toxic metals - Cu2 + and Hg2+ . The results show the stability of Negev desert microbial community to the extremely high bactericidal concentrations of toxic metals (1000 mg/l Cu2+and 10 mg/l Hg2+), despite the trace concentrations of these metals (0,23 mg/l Cu2+) in the desert ecosystem. This indicates a high resistance and ability of microbial cenosis to adapt to extreme factors. It can be supposed, ac

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11

Pförtner, Ramona [Verfasser], Wolfgang [Akademischer Betreuer] Brück, and Mikael [Akademischer Betreuer] Simons. "Astroglial and therapeutic factors affect demyelination in murine models with toxic demyelination / Ramona Pförtner. Gutachter: Wolfgang Brück ; Mikael Simons. Betreuer: Wolfgang Brück." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1048469824/34.

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12

Chahine, Samir. "Factors enhancing the interactions of lower rim calix[4]arene derivatives towards toxic metal cations in solution : versatile behaviour in the solid state." Thesis, University of Surrey, 2004. http://epubs.surrey.ac.uk/843546/.

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The synthesis of calix[4]arene derivatives, 5,11,17,23-tetra-tert-butyl[25,27-bis(hydroxy)-26,28-bis(ethylthioethoxy)]-calix[4]arene, L3, and 5,11,17,23-tetra-tert-butyl[25,27-bis(ethylethanoate)oxy-26,28-bis(ethylthioethoxy)]-calix[4]arene, L4, are reported. These ligands are structurally (1H, 13C NMR and X-ray crystallography) and thermodynamically (solubility, calorimetry) characterised. In addition to L3 and L4, 5,11,17,23-tetra-tert-butyl[25,26,27,28-tetrakis(ethylethanoate)- calix[4]arene, L1 and 5,11,17,23-tetra-tert-butyl[25,26,27,28-tetrakis(methylketonemethoxy)-calix[4]arene, L2, are

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13

Ramsay, Bruce A. "The use of complex toxic industrial waste as a fermentation substrate /." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75450.

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Two complex wastes were considered for biological conversion into a marketable product. One waste, peat runoff water (the waste-water that remains after the mining of peat), was found to be unsuitable for biological conversion to any product since it contained an insufficient quantity of carbon. The other waste, NVR (non-volatile residue, the major waste from the manufacture of nylon 6$ sp prime 6 sp prime$), was found to be a suitable carbon and energy source for the production of PHB (poly-$ beta$-hydroxybutyric acid) by Pseudomonas cepacia ATCC 17697. A general approach to the development o

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14

Bäckström, Nils, Hanna Egeman, and Hanna Mattsson. "Why do companies produce vegan and vegetarian products imitated with real meat products? : Exploring a virgin topic on the Swedish market." Thesis, Högskolan i Jönköping, Internationella Handelshögskolan, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-40016.

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With the support of four vegetarian and vegan companies established on the Swedish market, Astrid och Aporna, Ekko Gourmet, Tzay and Quorn, the objective of this study is to understand why companies produce vegan and vegetarian products imitated with real meat products as well as how these companies market these products. The data was collected through interviews with suitable representatives from respective company. The empirical data collected from the interviews have further been analysed together with theories from past researches. The research approaches of this study has been a mixture o

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15

Mitchell, Danielle. "Analysis of interactions between the A1 subunit of cholera toxin and ADP-ribosylation factor 6 /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Microbiology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 183-207). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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16

Downes-Tettmar, Naomi. "Factors that impact Pseudo-nitzschia spp. occurrence, growth, and toxin production." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1588.

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This work investigates, for the first time, the Pseudo-nitzschia (PN) dynamics in the western English Channel (L4) and the environmental factors impacting on domoic acid (DA) production in these waters. This is combined with laboratory studies examining key environmental factors and the multifactorial impact of multiple macronutrient and micronutrient availability on PN growth and DA production. An LC-MS method was established, optimised, and compared with ELISA for the accurate and reproducible extraction and determination of particulate and dissolved DA. The method was used to measure the se

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17

Bollinger, Laurie M. "Factors affecting prevalence of Shiga toxin-producing Escherichia coli in cattle /." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3329564.

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18

LEÃO, CLÁUDIO. "Desenvolvimento e validação de metodologia para a determinação de monocloroacetato de sódio e dicloroacetato de sódio em cocoamido,N-[(3-dimetilamino)propil],betaína via cromatografia a gás: GC/FID, GC/ECD e GC/MS." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26796.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-11-11T09:28:13Z No. of bitstreams: 0<br>Made available in DSpace on 2016-11-11T09:28:13Z (GMT). No. of bitstreams: 0<br>O monocloroacetato de sódio (MCAS) e o dicloroacetato de sódio (DCAS) são compostos tóxicos e irritantes ao ser humano e nocivos ao meio ambiente, sendo impurezas indesejáveis na cocoamido propil betaína (CAPB), que é um surfactante anfótero utilizado em produtos de consumo dos segmentos cosmético e domiciliar. Diante dos requisitos de concentração em nível de mg/kg exigidos pelos órgãos reguladores de saúde do gov

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19

Finnerty, Gerald Thomas. "Factors determining the transition to seizure in the tetanus toxin model of epilepsy." Thesis, Imperial College London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361453.

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20

Everling, Nils. "Extending the explanatory power of factor pricing models using topic modeling." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-210253.

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Factor models attribute stock returns to a linear combination of factors. A model with great explanatory power (R2) can be used to estimate the systematic risk of an investment. One of the most important factors is the industry which the company of the stock operates in. In commercial risk models this factor is often determined with a manually constructed stock classification scheme such as GICS. We present Natural Language Industry Scheme (NLIS), an automatic and multivalued classification scheme based on topic modeling. The topic modeling is performed on transcripts of company earnings calls

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21

Ahn, Kisuh. "Topic indexing and retrieval for open domain factoid question answering." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3794.

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Factoid Question Answering is an exciting area of Natural Language Engineering that has the potential to replace one major use of search engines today. In this dissertation, I introduce a new method of handling factoid questions whose answers are proper names. The method, Topic Indexing and Retrieval, addresses two issues that prevent current factoid QA system from realising this potential: They can’t satisfy users’ demand for almost immediate answers, and they can’t produce answers based on evidence distributed across a corpus. The first issue arises because the architecture common to QA syst

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22

Kejuo, Kingsley. "TOPIC: Critical Success Factors: Telecommunication Network equipment Procurement projects. A case study of MTN Nigeria." Thesis, KTH, Tillämpad maskinteknik (KTH Södertälje), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-118753.

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23

Mohammed, Hesham Hamada Taha. "Molecular analysis of adenylyl cyclase : bacillus anthracis edema factor exotoxin." kostenfrei, 2009. http://www.opus-bayern.de/uni-regensburg/volltexte/2010/1411/.

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Slater, Louise. "Identification of Host Factors Required for Anthrax Lethal Toxin Intoxication Using Chemical Genetic and RNAi Approaches." Thesis, Harvard University, 2011. http://dissertations.umi.com/gsas.harvard:10066.

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Bacterial toxins have co-opted host cell machinery in order to enter cells and exert their deleterious effects. Anthrax toxin is composed of the receptor binding protein protective antigen (PA), and the enzymatic subunits lethal factor (LF) and edema factor (EF), which form the binary toxin complexes lethal toxin, LeTx (PA + LF), and edema toxin, EdTx (PA + EF). PA binds to receptors on the surface of host cells and shuttles LF and EF into cells through the endocytic pathway. Upon endosome acidification, PA oligomers insert into the endosomal membrane and form functional pores that deliver LF

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25

Sittlington, Samuel Brian Kerr. "What are the factors that influence the effectiveness of anti-money laundering policy implementation in the UK? : exploring money laundering crime and policy." Thesis, Northumbria University, 2014. http://nrl.northumbria.ac.uk/36465/.

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Anti-Money Laundering has become the term for many stakeholders including Financial Institutions and law enforcement agencies that attempt to prevent the movement of money obtained from criminal activity. This research combines two important areas within the money laundering arena: Anti-Money Laundering preventative measures and Anti-Money Laundering Policy. This study aims to discover significant determinants that influence the current anti-money laundering policy (AML) by understanding the relationship between criminal activity, stakeholder activity and public policy. This research adopts a

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26

Boudreau, Denise M. "The association between HMG-CoA inhibitor use and breast cancer risk & a validation study of patient interview data and pharmacy records for antihypertensive, statin, and antidepressant medication use /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/7934.

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Alkimin, Gilberto Dias de [UNESP]. "Toxicidade de cádmio e zinco em Danio rerio: comparação entre valores permitidos em legislação para proteção da vida aquática e a potencial atuação como interferentes endócrinos." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/138031.

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Submitted by GILBERTO DIAS DE ALKIMIN null (gilberto_cdz@hotmail.com) on 2016-04-15T17:08:54Z No. of bitstreams: 1 Dissertação_FINAL.pdf: 6110695 bytes, checksum: c7822bb8a9272890beb5ba8faae113c6 (MD5)<br>Approved for entry into archive by Felipe Augusto Arakaki (arakaki@reitoria.unesp.br) on 2016-04-19T19:40:04Z (GMT) No. of bitstreams: 1 alkimin_gd_me_soro.pdf: 6110695 bytes, checksum: c7822bb8a9272890beb5ba8faae113c6 (MD5)<br>Made available in DSpace on 2016-04-19T19:40:04Z (GMT). No. of bitstreams: 1 alkimin_gd_me_soro.pdf: 6110695 bytes, checksum: c7822bb8a9272890beb5ba8faae113c6 (MD5

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Teixeira, Sergio de Mello Novita. "Caracterização genotípica de cepas de Pasteurella multocida proveniente de suínos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-29062012-135605/.

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Um total de 123 isolados de Pasteurella multocida provenientes de suínos foi avaliado através da PCR para pesquisa de genes codificadores de capsula, toxina dermonecrótica e outros fatores de virulência. As amostras foram caracterizadas como tipo capsular A (78,8 %) e tipo capsular D (21%). Nenhum dos isolados foi positivo para presença de toxina dermonecrótica. Os genes codificadores dos fatores de virulência pesquisados foram observados nas freqüências de 93,5 % para nanB, 92,7% para psl, 91,9% para oma87 e nanH, 87,8% para sodA,87% para hghA,83,7% para ompH, 82,9% para sodC, 79,7% para ptfA

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29

Santiesteban, Oscar. "Assessment of molecular interactions via magnetic relaxation: a quest for inhibitors of the anthrax toxin." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5481.

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Anthrax is severe disease caused by the gram-positive Bacillus anthracis that can affect humans with deadly consequences. The disease propagates via the release of bacterial spores that can be naturally found in animals or can be weaponized and intentionally released into the atmosphere in a terrorist attack. Once inhaled, the spores become activated and the anthrax bacterium starts to reproduce and damage healthy macrophages by the release of the anthrax toxin. The anthrax toxin is composed of three virulent factors: (i) anthrax protective antigen (APA), (ii) anthrax lethal factor (ALF), and

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30

Laabei, Maisem. "Using phospholipid vesicles to assay bacterial lytic agents, examining factors and identifying virulence loci which alter toxin production in Staphylococcus aureus." Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636526.

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Burns represent one of the most devastating forms of injury with infection complications representing the highest risk of mortality. The primary objective of the Bacteriosafe project was the development of a smart wound dressing that would respond to the presence of bacteria in burn wounds. The basis of this sensing system employed the use of phospholipid vesicles, containing a self-quenchable fluorescent dye. These vesicles mimic the eukaryotic cell membrane and as such are susceptible to bacterial cytolytic factors which lyse the vesicles, generating an observable and measurable fluorescent

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31

Heltshe, Sonya Lenore. "Quantification of length-bias in screening trials with covariate-dependent test sensitivity /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biostatistics, Department of Preventive Medicine and Biometrics) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 89-93). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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32

Heine, Wiebke Alexandra Verfasser], and Petra [Akademischer Betreuer] [Dersch. "The influence of the cytotoxic necrotizing factor toxin of Yersinia pseudotuberculosis on pathogenesis / Wiebke Alexandra Heine ; Betreuer: Petra Dersch." Braunschweig : Technische Universität Braunschweig, 2017. http://d-nb.info/1175817325/34.

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33

Phelps, Christopher. "The Importance of Listeriolysin O in Host Cell Invasion by Listeria monocytogenes and its Use in Vaccine Development." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555582881156988.

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34

Wetzel, Amy Noel. "Studies in Shiga toxin-producing Escherichia coli O157:H7 determination of factors contributing to the dissemination of Escherichia coli O157:H7 among dairy farms /." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1133239436.

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Paddock, Zachary Dean. "Shiga toxin producing Escherichia coli (STEC) in cattle: factors affecting fecal shedding of E. coli O157:H7 and detection methods of non-O157 STEC." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/15732.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>T. G. Nagaraja<br>Escherichia coli O157:H7 and over 380 non-O157 serotypes of Shiga toxin producing E. coli (STEC) are human food-borne pathogens that inhabit the hindgut of ruminants and are shed in the feces, which subsequently contaminate food products. Recent epidemiological data have shown that six non-O157 STEC (O26, O103, O111, O121, O45 and O145) account for majority of human STEC infections. Fecal shedding of STEC is influenced by a number of factors, including diets, supplements, and feed additives, because o

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Jaros, Mark J. "A joint model for longitudinal data and competing risks /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Biostatistics) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 117-119). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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37

Yenikent, Seren [Verfasser], and Joachim [Akademischer Betreuer] Kimmerle. "Understanding the effects of topic factors and threat exposure on motivation to participate in knowledge artefacts : The case of Wikipedia / Seren Yenikent ; Betreuer: Joachim Kimmerle." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1204880891/34.

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38

Kreutz, Philippe. "Les prédicats factifs: une enquête logique et linguistique." Doctoral thesis, Universite Libre de Bruxelles, 1995. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212508.

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Alazzabi, Mufida. "Insulin-like growth factor-II (IGF2) gene of zebrafish and its use as a biogenetic marker for the assay of epigenetic toxin exposure." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26561.

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The purpose of this research was to determine whether expression analysis of the IGF2 gene in zebrafish, a gene whose transcription is known to be regulated by DNA methylation in mammals, can be used as a marker or indicator of DNA methylation due to toxin exposure in fish embryos. We examined the expression of IGF2, IGF1, and IGFBP-1 in zebrafish embryos treated with sodium arsenite (thought to inhibit DNA methylation), nickel chloride (thought to cause DNA hypermethylation), trichostatin A (a histone deacetylase inhibitor), 5-azaC (thought to cause methyltransferase inhibition), cadmium chl

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40

Mercado, Salazar Jorge Anibal, and S. M. Masud Rana. "A Confirmatory Analysis for Automating the Evaluation of Motivation Letters to Emulate Human Judgment." Thesis, Högskolan Dalarna, Institutionen för information och teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:du-37469.

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Manually reading, evaluating, and scoring motivation letters as part of the admissions process is a time-consuming and tedious task for Dalarna University's program managers. An automated scoring system would provide them with relief as well as the ability to make much faster decisions when selecting applicants for admission. The aim of this thesis was to analyse current human judgment and attempt to emulate it using machine learning techniques. We used various topic modelling methods, such as Latent Dirichlet Allocation and Non-Negative Matrix Factorization, to find the most interpretable top

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41

St, Pierre Liam Daniel. "Identification and comparative analysis of novel factors from the venom gland of the coastal taipan (Oxyuranus scutellatus) and related species." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16677/1/Liam_St_Pierre_Thesis.pdf.

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Snake venoms are a complex mixture of polypeptide and other molecules that adversely affect multiple homeostatic systems within their prey in a highly specific and targeted manner. Amongst the most potently toxic venoms in the world are those of the Australian venomous snakes, which belong almost exclusively to the elapid family. Their venoms posses a number of unique properties by which they target the mammalian cardiovascular and neuromuscular systems and are the focus for the identification of novel pharmacologically interesting compounds which may be of diagnostic or therapeutic benefit. A

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St, Pierre Liam Daniel. "Identification and comparative analysis of novel factors from the venom gland of the coastal taipan (Oxyuranus scutellatus) and related species." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16677/.

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Snake venoms are a complex mixture of polypeptide and other molecules that adversely affect multiple homeostatic systems within their prey in a highly specific and targeted manner. Amongst the most potently toxic venoms in the world are those of the Australian venomous snakes, which belong almost exclusively to the elapid family. Their venoms posses a number of unique properties by which they target the mammalian cardiovascular and neuromuscular systems and are the focus for the identification of novel pharmacologically interesting compounds which may be of diagnostic or therapeutic benefit. A

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Larsson, Malin. "Computational methods for analyzing dioxin-like compounds and identifying potential aryl hydrocarbon receptor ligands : multivariate studies based on human and rodent in vitro data." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-139487.

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Polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) are omnipresent and persistent environmental pollutants. In particular, 29 congeners are of special concern, and these are usually referred to as dioxin-like compounds (DLCs). In the European Union, the risks associated with DLCs in food products are estimated by a weighted sum of the DLCs’ concentrations. These weights, also called toxic equivalency factors (TEFs), compare the DLCs’ potencies to the most toxic congener, 2,3,7,8-tetrachloro-dibenzo-p-dioxin (2378- TCDD). The toxicological effects of

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Gauthier, Audrey, and Audrey Gauthier. "Analyse de l'expérience d'hommes qui participent à un groupe psychoéducatif dans le cadre du programme Toxico-Justice offert en milieu carcéral sous l'angle des facteurs d'aide." Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27962.

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Les groupes de traitement de la toxicomanie en milieu carcéral offrent un contexte d’intervention particulier. Bien que plusieurs études abordent leur efficacité, les processus d’intervention qui y prennent place ont été très peu explorés dans les écrits scientifiques. Il devenait alors pertinent d’entreprendre cette recherche, qui tente de saisir l’expérience des hommes qui participent à un groupe psychoéducatif dans le cadre du programme Toxico-Justice offert en milieu carcéral. S’inscrivant dans la perspective de l’interactionnisme symbolique, l’étude utilise l’entretien qualitatif semi-dir

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Albornoz, Luis Antonio Llanco. "Caracterização molecular dos principais fatores de virulência e genótipos de Clostridium perfringens isolados de frangos com enterite necrótica." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-27062014-164523/.

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Clostridium perfringens causa enterite necrótica aviária devido à produção de toxinas que lesam o intestino. Neste estudo, de 94 amostras nove apresentaram C. perfringens, totalizando 22 isolados. Todos exceto um isolado, possuíram os genes nanI (95%) e/ou nanJ (81%), e 19/22, mostraram atividade neuraminidase em hemácias de frango. A atividade hemaglutinante foi observada em poucos isolados (26%). Todos os isolados foram plc positivos (toxina α), sendo classificados como tipo A. Sete isolados (31,8%) abrigaram o gene tpeL que codifica a toxina TpeL. Isolados tpeL+ mostraram efeito citot

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Corelli, Barbara. "Investigation of Klebsiella virulence : the role of capsule in Klebsiella rhinoscleromatis pathogenesis and characterization of a Klebsiella pneumoniae capsule mutant unable to produce colibactin toxin." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC265/document.

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L’émergence et la dissémination récentes de clones hypervirulents et multi-résistants de Klebsiella pneumoniae ont renouvelé l'intérêt général envers Klebsiella. Cependant, notre connaissance de la pathogénèse de Klebsiella au niveau moléculaire et cellulaire reste faible. Dans ce travail, nous avons mené deux axes de recherche focalisés sur la pathogénèse de Klebsiella. Le premier projet visait à caractériser un mutant de capsule de K. pneumoniae incapable de produire une toxine colibactine fonctionnelle. La colibactine est un métabolite secondaire génotoxique produit principalement par des s

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Gauriat, Marie-Anne. "Connaissance des facteurs déterminants dans la conduite d'un procédé pour la production de toxine par Corynebacterium diphteriae utilisée dans la formulation de vaccins." Thesis, Toulouse, INSA, 2012. http://www.theses.fr/2012ISAT0041/document.

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Avec pour problématique une importante variabilité des lots de production vaccinale contre la diphtérie, une analyse intégrative du métabolisme central, du fer et du transcriptome de Corynebacterium diphtheriae, cultivé en conditions les plus proches de la culture industrielle, ont permis d’élargir les connaissances sur le comportement de la bactérie en conditions de production industrielle, et plus particulièrement sur l’existence de corrélations entre activité métabolique et virulence. L'analyse du métabolisme central et la comparaison de l'expression des gènes de C. diphtheriae, ont permis

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Mathevon, Laure. "Analyse des facteurs pronostics d’efficacité du traitement de la spasticité par injection de toxine botulinique. De l’analyse du muscle spastique en imagerie ultrasonore à l’immunisation post injection de toxine botulinique." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSES023/document.

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Notre objectif était de rechercher une méthode d’évaluation musculaire afin de déterminer des facteurs de non réponse tissulaire à une injection de toxine botulique (TB) dans un muscle spastique, chez l’adulte post AVC et chez l’enfant paralysé cérébral (PC). Une étude de reproductibilité et 3 revues systématiques de la littérature ont été réalisées. Les mesures échographiques de l’épaisseur et de l’angle des pennation des fibres du muscle gastrocnémien médial en 2D sont reproductibles. La mesure du module d’élasticité par Shear Wave Ultrasound Elastography délivre une information fiable sur l

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Haji, mansor Muhammad. "Functionalized polymer implants for the trapping of glioblastoma cells Development of a non-toxic and non-denaturing formulation process for encapsulation of SDF-1α into PLGA/PEG-PLGA nanoparticles to achieve sustained release Reversing the Tumor Target: Establishment of a Tumor Trap". Thesis, Angers, 2019. http://www.theses.fr/2019ANGE0015.

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Le glioblastome (GBM) est la forme de cancer du cerveau la plus courante et la plus meurtrière. Sa nature diffusive entraine une impossibilité d’élimination complète par chirurgie. Une récidive de la tumeur chez ≥ 90% des patients peut être provoqué par des cellules GBM résiduelles se trouvant près du bord de la cavité de résection. Un implant pouvant libérer de manière durable la protéine SDF-1α, qui se lie aux récepteur CXCR4 à la surface des cellules GBM, peut être utile pour induire le recrutement des cellules GBM résiduelles, permettre leur élimination sélective et finalement réduire la r

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Vdovikova, Svitlana. "Roles of membrane vesicles in bacterial pathogenesis." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138714.

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The production of membranous vesicles is observed to occur among organisms from all domains of the tree of life spanning prokaryotes (bacteria, archaea) and eukaryotes (plants, animals and fungi). Bacterial release of membrane-derived vesicles (MVs) has been studied most extensively in cases of Gram-negative species and implicating their outer membrane in formation of extracellular MVs. However, recent studies focusing on Gram-positive bacteria have established that they also undergo MV formation. Membrane vesicles are released during normal bacterial growth, they are derived from the bacteria

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