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Rozprawy doktorskie na temat „Toxicity profile”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Moolla, A., Vuuren SF Van, Zyl RL Van, and AM Viljoen. "Biological activity and toxicity profile of 17 Agathosma (Rutaceae) species." Elsevier B.V, 2007. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001019.

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The antimicrobial, anti-oxidant and cytotoxic activities of the extracts obtained from 17 indigenous Agathosma species (19 samples) were investigated in order to validate the historic and continued use of Agathosma species in traditional healing. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method on four pathogens, i.e. Staphylococcus aureus (ATCC 12600), Bacillus cereus (ATCC 11778), Klebsiella pneumoniae (NCTC 9633) and Candida albicans (ATCC 10231). The anti-oxidant activity was evaluated using the 2,2- diphenyl-1-picrylhydrazyl radical (DPPH) a

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Vevers, William F. "Deoxynivalenol : toxicological profile and potential for reducing cereal grain contamination using bacterial additives in fermented animal feed." Thesis, University of Plymouth, 2015. http://hdl.handle.net/10026.1/4305.

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Deoxynivalenol (DON) contamination of grain destined for animal feeds is a major toxicological risk to monogastrics and is suspected of restricting productivity in ruminants. Whereas bacterial additives have been developed that can detoxify DON in the rumen and lower intestine, there are currently no commercial inoculants able to perform this task in crimped grain (CG) silage, a regionally important method of moist grain preservation based on homo- and heterofermentative lactic acid bacteria or chemical additives. Determining whether this ensiling process alongside the action of detoxifying ba

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Mesquita, Andreia Filipa da Costa. "Effects of copper sulphate on the fatty acids profile and enzymatic activity of marine bivalve species." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22323.

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Mestrado em Toxicologia e Ecotoxicologia<br>In the past years, an intensive usage of fertilizers and pesticides has been reported, mainly in the Mediterranean region, due to the wide agriculture production required to increase food production to respond to world exponential growth of human population. Copper, with several applications at industrial and agricultural activities is often discharged in the aquatic systems and this input can lead to damages to the ecosystems and its communities. Copper sulphate, is found in pesticides and fertilizers formulations, frequently used in the agricultura

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Pereira, José Carlos da Silveira. "Estudo alelopático, fitoquímico e genotóxico de extratos aquosos de Aspidosperma pyrifolium Mart. e Combretum leprosum Mart. em Allium cepa." Universidade Federal Rural do Semi-Árido, 2015. http://bdtd.ufersa.edu.br:80/tede/handle/tede/788.

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Submitted by Lara Oliveira (lara@ufersa.edu.br) on 2017-08-07T21:51:39Z No. of bitstreams: 1 JoséCSP_DISSERT.pdf: 861903 bytes, checksum: 5f78fa00a8f44435ec8fd2bebd231afc (MD5)<br>Approved for entry into archive by Vanessa Christiane (referencia@ufersa.edu.br) on 2017-08-17T22:38:54Z (GMT) No. of bitstreams: 1 JoséCSP_DISSERT.pdf: 861903 bytes, checksum: 5f78fa00a8f44435ec8fd2bebd231afc (MD5)<br>Approved for entry into archive by Vanessa Christiane (referencia@ufersa.edu.br) on 2017-08-17T22:40:52Z (GMT) No. of bitstreams: 1 JoséCSP_DISSERT.pdf: 861903 bytes, checksum: 5f78fa00a8f44435ec8fd2be

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Bispo, James Romero Soares. "Avaliação das atividades toxicológicas e microbiológicas de chás industrializados." Universidade Federal de Alagoas, 2006. http://www.repositorio.ufal.br/handle/riufal/2497.

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The use of medicinal plants has always been a constant in the folk medicine of different civilizations around the world. However, their pharmacological activities are still poorly studied. This work aims to study the toxicological and microbiological activity of industrialized teas of Black Tea (Camellia sinensis), chamomile (Matricaria recutita), Fennel (Foeniculum vulgare L.) and spearmint (Mentha piperita) in Swiss albino mice. There were made aqueous and alcoholic extracts of the teas in study. Those who had strong antimicrobial and toxicological activity had their ethanolic extracts fract

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Silva, Artur Christian Garcia da. "Desenvolvimento de modelo biomimético de córnea para avaliação da toxicidade ocular de produtos farmacêuticos: perfil inflamatório, caracterização e aplicabilidade." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8480.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2018-05-16T11:00:44Z No. of bitstreams: 2 Dissertação - Artur Christian Garcia da Silva - 2018.pdf: 3769532 bytes, checksum: e167ec43ef90135ed1fc8434ff29e2b3 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-05-16T11:01:38Z (GMT) No. of bitstreams: 2 Dissertação - Artur Christian Garcia da Silva - 2018.pdf: 3769532 bytes, checksum: e167ec43ef90135ed1fc8434ff29e2b3 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf842

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Ebbrell, D. J. "The development of a fragment-based in silico profiler for the prediction of thiol reactivity and toxicity." Thesis, Liverpool John Moores University, 2018. http://researchonline.ljmu.ac.uk/9686/.

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Regulatory toxicology in the 21st century is faced with the challenge of having to replace its use of experimental animals in chemical risk assessment with alternative methods. This is due to the introduction of the REACH legislation and the seventh amendment to the cosmetics directive. Such alternative methods include the use of in vitro (cell culture/tissue etc.), in chemico (chemical experiments e.g. determination of reactivity) and in silico (computational) approaches. Importantly, it is envisaged that data from all these alternative sources will be required for the prediction of the anima

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8

Houeto, Paul. "Profil toxicologique des victimes d'incendie en milieu urbain : role des toxiques systemiques dans la mortalite prehospitaliere." Paris 5, 1997. http://www.theses.fr/1997PA05N112.

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9

Masango, Mxolisi Goodwill. "A comparative analysis of the cytotoxicity of cyanotoxins using in vitro (cell culture) and in vivo (mouse) assays." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-05122008-100402/.

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10

Wessel, Nathalie. "Etude des voies de bioactivation du benzo[a]pyrène et du fluoranthène chez la sole commune (Solea solea) : profil métabolique et toxicité." Nantes, 2010. http://www.theses.fr/2010NANT2066.

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Michielan, Lisa. "Advance Methodologies in Linear and Nonlinear Quantitative Structure-Activity Relationships (QSARs): from Drug Design to In Silico Toxicology Applications." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3422242.

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Novel computational strategies are continuously being demanded by the pharmaceutical industry to assist, improve and speed up the drug discovery process. In this scenario chemoinformatics provide reliable mathematical tools to derive quantitative structure-activity relationships (QSARs), able to describe the correlation between molecular descriptors and various experimental profiles of the compounds. In the last years, nonlinear machine learning approaches have demonstrated a noteworthy predictive capability in several QSAR applications, confirming their superiority over the traditional linear

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12

Lambert, Carine. "Approches transcriptomiques in vitro de l’hépatotoxicité des xénobiotiques : optimisation des conditions expérimentales et étude comparée des effets de différents composés." Rennes 1, 2008. http://www.theses.fr/2008REN1S185.

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La toxicogénomique consiste à analyser les profils transcriptomiques de milliers de gènes à un instant donné. Discipline récente, elle vise à la fois à évaluer le potentiel toxique de nouveaux médicaments et à identifier les mécanismes moléculaires impliqués. Le type de toxicité d’origine médicamenteuse principalement rencontré chez l’homme est l’hépatotoxicité du fait de la place privilégiée qu’occupe le foie dans le métabolisme des médicaments. Aussi, notre étude a consisté, dans un premier temps, à valider l’approche transcriptomique pour des études d’hépatotoxicité in vitro en utilisant le

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13

"Differential expression profile of cytochrome p450 2E1 (CYP2E1) related genes associated with carbon tetrachloride-induced hepatotoxicity." 2004. http://library.cuhk.edu.hk/record=b6073721.

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Avasarala Sreedevi.<br>"December 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 253-272)<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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14

Tsai, Chieh-ting, and 蔡杰廷. "Longitudinal metabolite profile and effects of arsenite toxicity for zebrafish：studies by vitro NMR spectroscopy and 1H NMR metabonomics." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/61440973580001429356.

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碩士<br>淡江大學<br>生命科學研究所碩士班<br>98<br>Arsenic is common compounds in nature, and caused many public health problems in Taiwan. Organisms take in arsenic lead to abnormal physiological function. Low concentrations promote cell proliferation. High concentrations inhibit the metabolism and cause multiple organ disease. Generally, inorganic arsenic is usually more toxic than organic arsenic. Organisms take in inorganic arsenic the detoxification pathway is through the methylation into organic arsenic. The zebrafish is an animal model in this thesis. Use solvent to extraction and freeze-dried the z

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Tang, Ming-Chi, and 唐銘圻. "Folate supplementation and Memantine treatment modified gene expression profile in brain of Tg2576 transgenic mice and protected against Abeta-induced neuron toxicity." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/73082510289623186776.

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碩士<br>輔仁大學<br>營養科學系<br>99<br>Memantine is an approved option clinical drug for the treatment of Alzheimer’s disease (AD) with only moderate therapeutic effect. Folate supplementation was not associated to decrease risk of AD、yet mechanism are unclear. This study was to investigate whether and how mechanism by which folate supplement or/and Memantine protect against amyloid-β (Aβ)-induce neurotoxicity. Effects of folate supplementation (8 mg/kg/day) on the brain of gene expression profile of Memantine (30 mg/kg/day) -treated AD transgenic Tg2576 mice、were analysis using cDNA microarrays. Expres

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DORT, Hynek. "Vliv pesticidů na hematologický a biochemický profil ryb." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-51152.

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Cílem práce bylo zhodnotit vliv pesticidů na bázi triazinů (účinná látka metribuzin) a pyrethroidů (účinná látka bifenthrin) na kapra obecného (Cyprinus carpio) na základě výsledků testu akutní toxicity a výsledků hematologického a biochemického vyšetření plazmy. Hodnota 96hLC50 pro přípravek Sencor 70 WG (s účinnou látkou 70% metribuzinu) byla 250,2 mg.l-1. U kapra obecného po 96h expozici v koncentraci 250,2 mg.l-1 Sencoru 70 WG došlo k významnému snížení (p<0,01) celkových bílkovin, triglyceridů, laktát dehydrogenázy, anorganického fosfátu, hodnot hemoglobinu, hematokritové hodnoty, střední

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Hubsch, Zelna. "Antimicrobial efficacy and toxicity profiles of conventional antimicrobial agents in combination with commercially relevant southern African medicinal plants." Thesis, 2014. http://hdl.handle.net/10539/15308.

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Thesis (M.Pharm.)--University of the Witwatersrand, Faculty of Health Sciences, 2014.<br>Traditional medicine plays a vital role in the cultural heritage of many South Africans, with at least 80% of the population relying on medicinal plants for their primary source of healthcare. It has been acknowledged that even in some of the finest hospitals in South Africa, people are often found to be using traditional medicine in combination with conventional treatment regimens. Despite the substantial use of medicinal plants in South Africa, limited information is available on the interactive properti

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18

Shvachiy, Liana. "Comparative study on the physiological dynamics evoked by different profiles of lead exposure." Master's thesis, 2018. http://hdl.handle.net/10451/37849.

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Tese de mestrado, Neurociências, Universidade de Lisboa, Faculdade de Medicina, 2018<br>Lead is a toxic metal which widespread use has resulted in environmental contamination and significant health problems. It is a cumulative toxicant that affects multiple body systems, including the cardiovascular, hematopoietic, reproductive, and renal systems. Lead is also a well-known neurotoxin, inducing changes in neurogenesis, neurodegeneration and changes on glial cells. These changes in the molecular and cellular processes lead to cognitive and behaviour alterations, particularly during developmental

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Konečný, Ladislav. "Mobilita anorganických kontaminantů a jejich toxicita v půdních profilech v oblasti hutě Mufulira (Copperbelt, Zambie)." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-312697.

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ii SUMMARY The smelter in Mufulira is one of the several active copper smelters in Copperbelt area in Zambia. It had operated for almost 70 years and during that period all offgas and dust were released into the atmosphere. Six profiles, three of them beneath trees, were sampled in the distances of 3.6, 8 and 24 km from the smelter. Each profile consisted of 9-10 layers collected continuously from the topsoil till depth of 60-70 cm. Following parameters were measured for each layer: pH, TC, TS a CEC, then total concentration of Ag, As, Al, Fe, Co, Cr, Cu, Mn, Mo, Ni, Pb, Sb, Se, Sn, V a Zn and

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St-Jean, Mélissa. "Le profil alimentaire et d'exposition aux polluants sanguins (métaux, biphényles polychlorés et pesticides organochlorés) : les relations entre la diète et la multicontamination, ainsi que les effets de ces polluants sur la thyrotropine, les hormones thyroïdiennes et la prolactine des Innus du Labrador." Mémoire, 2007. http://www.archipel.uqam.ca/4753/1/M10006.pdf.

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Les Innus du Labrador sont des consommateurs de nourriture traditionnelle. Cette dernière est nutritive et intègre divers aspects social, culturel, traditionnel, spirituel et économique fondamentaux pour leur bien-être. Malgré ses bénéfices, elle peut aussi contenir des polluants environnementaux potentiellement dangereux pour leur santé. Les hormones thyroïdiennes (THs) sont impliquées dans diverses fonctions dont la lactation, principalement contrôlée par la prolactine (PRL). Certains polluants sont connus pour affecter ces hormones. La constitution exacte du mélange de polluants dans la nou

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