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Rozprawy doktorskie na temat „Toxicology”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Malheiro, Ana Cristina Calhabeutt Gabriel da Costa. "Determinação espectrofotométrica da caboxiemoglobinemia em indivíduos expostos ocupacionalmente ao monóxido de carbono." Universidade de São Paulo, 1991. http://www.teses.usp.br/teses/disponiveis/9/9137/tde-03032015-160133/.

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O monóxido de carbono (CO) constitui sério risco à saúde de indivíduos expostos a este gás. Os efeitos nocivos aparecem como conseqüência de sua combinação com a hemoglobina formando a carboxiemoglobina(COHb). A avaliação da exposição ao CO pela monitorização biológica é realizada, preferencialmente, pela determinação da carboxiemoglobinemia. O método espectrofotométrico proposto, para a determinação de COHb, utiliza a leitura na região Soret (420 e 432 nm) e fatores de calibração do espectrofotômetro. É realizado estudo comparativo entre o uso do CO obtido por reação química e o de cilindro d

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2

Oliveira, Ricardo Jorge Dinis. "Toxicity of Paraquat in Isolated Rat Lung. Search for Efficient Antidotes." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2006. http://hdl.handle.net/10216/7369.

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Doutoramento<br>PhD Degree<br>The immune evasion mechanisms of pathogenic trypanosomatids involve a multitude of phenomena such as the polyclonal activation of lymphocytes, cytokine modulation and the enhanced detoxification of oxygen reactive species. A trypanothione-cascade seems to be involved in the detoxification process. We have recently described and characterized a tryparedoxin (LiTXN1) involved in the Leishmania infantum cytoplasmatic hydroperoxide metabolism. LiTXN1 is a secreted protein upregulated in the infectious form of the parasite, suggesting that it can play an important role

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3

Costa, Vera Marisa Freitas. "Role of catecholamines and reactive oxygen species in the mechanism of oxidative stress-induced heart disease:in vitro studies using fresly isolated rat cardiomyocytes." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2008. http://hdl.handle.net/10216/20812.

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Pontes, Helena de Oliveira. "Toxicological and Toxicokinetic Interactions Between Ethanol and Ecstasy. In Vivo and In Vitro Studies." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2008. http://hdl.handle.net/10216/9486.

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Alves, Ema Luís Pereira Gomes. "Neurotoxicity of Methylenedioxymethamphetamine (MDMA; Ecstasy) and its Main Metabolites, on Rat Brain Mitochondria In Vitro and In Vivo - Behavioral Consequences." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2007. http://hdl.handle.net/10216/7499.

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6

Monteagudo, Maykel Cruz. "Multi-Objective Optimization Based on Desirability Estimation of Several Interrelated Responses (MOOp-DESIRe): A Computer-Aided Methodology for Multi-Criteria Drug Discovery." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/63799.

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7

Monteagudo, Maykel Cruz. "Multi-Objective Optimization Based on Desirability Estimation of Several Interrelated Responses (MOOp-DESIRe): A Computer-Aided Methodology for Multi-Criteria Drug Discovery." Tese, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/63799.

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8

Alves, Ema Luís Pereira Gomes. "Neurotoxicity of Methylenedioxymethamphetamine (MDMA; Ecstasy) and its Main Metabolites, on Rat Brain Mitochondria In Vitro and In Vivo - Behavioral Consequences." Tese, Faculdade de Farmácia da Universidade do Porto, 2007. http://hdl.handle.net/10216/7499.

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9

Costa, Vera Marisa Freitas. "Role of catecholamines and reactive oxygen species in the mechanism of oxidative stress-induced heart disease:in vitro studies using fresly isolated rat cardiomyocytes." Tese, Faculdade de Farmácia da Universidade do Porto, 2008. http://hdl.handle.net/10216/20812.

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10

Oliveira, Ricardo Jorge Dinis. "Toxicity of Paraquat in Isolated Rat Lung. Search for Efficient Antidotes." Tese, Faculdade de Farmácia da Universidade do Porto, 2006. http://hdl.handle.net/10216/7369.

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Doutoramento<br>PhD Degree<br>The immune evasion mechanisms of pathogenic trypanosomatids involve a multitude of phenomena such as the polyclonal activation of lymphocytes, cytokine modulation and the enhanced detoxification of oxygen reactive species. A trypanothione-cascade seems to be involved in the detoxification process. We have recently described and characterized a tryparedoxin (LiTXN1) involved in the Leishmania infantum cytoplasmatic hydroperoxide metabolism. LiTXN1 is a secreted protein upregulated in the infectious form of the parasite, suggesting that it can play an important role

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11

Pontes, Helena de Oliveira. "Toxicological and Toxicokinetic Interactions Between Ethanol and Ecstasy. In Vivo and In Vitro Studies." Tese, Faculdade de Farmácia da Universidade do Porto, 2008. http://hdl.handle.net/10216/9486.

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12

Hoffmann, Sebastian. "Evidence-based in vitro toxicology." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975776207.

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13

Holmgren, Per. "Postmortem toxicology : aspects on interpretation /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med862s.pdf.

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14

Wilson, Joanne Patricia. "The molecular toxicology of butadiene." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287826.

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15

Crouch, David G. "A political sociology of toxicology." Thesis, University of Sussex, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.694645.

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16

Kim, Hea-Young. "Molecular Toxicology of Pyrrolizidine Alkaloids." DigitalCommons@USU, 1994. https://digitalcommons.usu.edu/etd/3910.

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Pyrrolizidine alkaloids are cytotoxic, carcinogenic, and anti-carcinogenic in vivo and in vitro, and they produce many hazardous effects in humans and animals. Pyrrolizidine alkaloids (PAs) also cross-link with DNA and/or protein. However, whether such cross-linking is important to the toxic action of PAs is not known. In addition, the exact mechanism underlying these DNA cross-links or cytotoxicity is also not clear. In three separate studies, I characterized the nature of PA-induced DNA cross-links and the relationships between PA structures and cross-linking potency. In the first study (Cha

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17

Neagu, Daniel, and A.-N. Richarz. "Big data in predictive toxicology." Royal Society of Chemistry, 2019. http://hdl.handle.net/10454/17603.

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No<br>The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput screening resources. However, the amplified pace and capacity of data generation achieved by these novel techniques presents challenges for organising and analysing data output. Big Data in Predictive Toxicology discusses these challenges as well as the

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18

Frank, Evan A. "Toxicology and Mechanisms of Lung Responses to Carbon Nanotube Exposures." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448037426.

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19

Ouchi, Rejane Yuriko [UNESP]. "Avaliação dos efeitos do brometo de etídio em Drosophila melanogaster (Diptera-Drosophilidae)." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/100512.

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Made available in DSpace on 2014-06-11T19:30:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-10-31Bitstream added on 2014-06-13T20:40:50Z : No. of bitstreams: 1 ouchi_ry_dr_sjrp.pdf: 1860080 bytes, checksum: 6ea294f1febce43f75eaaecd7bef2497 (MD5)<br>A cada ano, milhares de novos compostos químicos entram no mercado, e um volume enorme de resíduos é gerado pela atividade humana, existindo uma grande preocupação com relação aos seus efeitos a curto e longo prazo sobre a saúde e o ambiente. Um grande número dessas substâncias químicas é potencialmente perigoso e pode acarretar efeit

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20

Farina, Massimo. "Metallomics in in vitro toxicology research." Doctoral thesis, Universitat Autònoma de Barcelona, 2008. http://hdl.handle.net/10803/3924.

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Los metales son ubicuos y su acumulación cada vez mayor en el ambiente conduce a serias preocupaciones en términos de seguridad ambiental, ocupacional y del consumidor. Entre otros efectos potenciales sobre la salud, la carcinogenicidad y la neurotoxicidad inducidas por los metales representan un riesgo importante para la sociedad humana y, por lo tanto, merecen ser determinadas completamente. En este contexto, se necesita llevar a cabo un amplio proyecto de investigación in vitro en estas áreas en compuestos metálicos seleccionados. El trabajo se refiere a investigaciones en metalómica destin

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21

Sharma, Raju Prasad. "Integrative Systems Toxicology For Human Health." Doctoral thesis, Universitat Rovira i Virgili, 2018. http://hdl.handle.net/10803/665621.

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Els disruptors endocrins (DE) són substàncies naturals o antropogèniques presents el ambient, aliments o productes de consum que poden alterar els equilibris hormonals en humans i animals i produir efectes adversos per a la salut fins i tot a dosis baixes. S'han desenvolupat nombrosos mètodes, sota l'orientació de la UE i OCD, amb l'objectiu de realitzar avaluacions de riscos quantitatius per a aquests substàncies, tanmateix, aquests mètodes encara no tenen la confiança en el nivell de seguretat per a l'exposició humana. La predicció quantitativa dels efectes adversos dels DE en la salut human

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22

Cheng, Crystal. "Toxicology of nanoparticles after cellular uptake." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/245264.

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Nanoscience is a multi-disciplinary field with the potential to both create new applications and understand existent systems, but its materials may be sources of toxicological concern. Understanding their toxic potential becomes essential to prevent any occupational, environmental, and consumer hazards. In this study, the toxicity of three different nanoparticles (NPs) was assessed: multi-walled carbon nanotubes (MWNTs), single-walled carbon nanotubes (SWNTs), and zinc oxide (ZnO) nanopowders. A combination of cell viability assays—NR, MTT, LDH, live dead—and microscopy—TEM, SEM, confocal—was

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23

Rogerson, Jonathan G. "Biosensor technology : applications in microbial toxicology." Thesis, University of Bedfordshire, 1997. http://hdl.handle.net/10547/621817.

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This work describes the development of mediated amperometric biosensors that are able to monitor the metabolic activity of both single and mixed microbial populations, with applications in toxicity assessment and wastewater treatment plant protection. Biosensor systems have been constructed incorporating either the single-species eubacteria Escherichia coli or Pseudomonas putida, Bioseed®, or a mixture of activated sludge organisms from wastewater treatment plants, as the sensing components immobilised on disposable screen printed electrodes in stirred reaction vials. The biosensor approach is

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Dempsey, R. "The genetic toxicology of carcinogenic compounds." Thesis, Swansea University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636437.

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This thesis involved the development of a range of assay systems for the detection of environmental mutagens and carcinogens. Initially a protocol was optimised for the induction of mitotic gene conversion in stationary-phase cultures of the yeast <i>Saccharomyces cerevisiae</i>, strain JD1 following exposure to compounds which require exogenous metabolic activation, which involved an initial incubation at 37<SUP>o</SUP>C for 2 hours followed by a 16 hour incubation at 28<SUP>o</SUP>C. This protocol was found to be effective for the detection of cyclophosphamide and sterigmatocystin. In two se

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25

Winstanley, Peter Andrew. "The pharmacology and toxicology of amodiaquine." Thesis, University of Liverpool, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237571.

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26

Nassr, Azize Cristina Capelli. "Desenvolvimento reprodutivo de ratos machos expostos ao fenvalerato in utero e lactação." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/318041.

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Orientador: Wilma De Grava Kempinas<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-05T10:14:11Z (GMT). No. of bitstreams: 1 Nassr_AzizeCristinaCapelli_M.pdf: 10674778 bytes, checksum: 6e73e575f70e9f4c4cdd81eb7eac3586 (MD5) Previous issue date: 2005<br>Resumo: o fenvalerato é um inseticida piretróide sintético usado na agricultura, pecuária e no controle de insetos domésticos, e seus efeitos reprodutivos são pouco conhecidos. Algunsestudos têm proposto que o fenvaleratoseja um desregulador endócrino,atuando como um e

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Ouchi, Rejane Yuriko. "Avaliação dos efeitos do brometo de etídio em Drosophila melanogaster (Diptera-Drosophilidae) /." São José do Rio Preto : [s.n.], 2011. http://hdl.handle.net/11449/100512.

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Orientador: Gustavo Orlando Bonilla Rodriguez<br>Coorientador: Carlos Roberto Ceron<br>Banca: Eduardo Alves Almeida<br>Banca: Lucilene Regina Maschio<br>Banca: Lilian Castiglione<br>Banca: Rogério Pincela Mateus<br>Resumo: A cada ano, milhares de novos compostos químicos entram no mercado, e um volume enorme de resíduos é gerado pela atividade humana, existindo uma grande preocupação com relação aos seus efeitos a curto e longo prazo sobre a saúde e o ambiente. Um grande número dessas substâncias químicas é potencialmente perigoso e pode acarretar efeitos biológicos deletérios, sendo que mudan

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Tanamachi, Amanda Rodrigues A. R. "Potencial toxicogenômico do contaminante ambiental 2-fenilbenzotriazol-9 não clorado (non-Cl PBTA-9) in vivo." Botucatu, 2020. http://hdl.handle.net/11449/192455.

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Orientador: Daisy Maria Fávero Salvadori<br>Resumo: O setor industrial, em constante expansão, gera, diariamente, resíduos com elevado potencial tóxico ao ambiente. Nesse contexto, a indústria têxtil apresenta grande impacto poluidor para a hidrosfera, devido aos compostos e processos químicos utilizados na coloração de tecidos. A literatura mostra que não há eficiência na remoção desses compostos, tanto por parte das fábricas, como em Estações de Tratamento de Água (ETAs) para o abastecimento humano. Pelo contrário, o processo de descontaminação pode tornar corantes do grupo azo, por exemplo,

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Phelps, Jennifer Suzanne 1960. "CISPLATIN NEPHROTOXICITY: IN VITRO STUDIES (KIDNEY, TOXICOLOGY, PLATINUM)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/291243.

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Kultima, Kim. "Transcriptomics and Proteomics Applied to Developmental Toxicology." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7921.

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Smith, Catherine Clare. "The genetic toxicology of DNA-based products." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406671.

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Gal, Aharon. "The toxicology of nitric oxide In vitro." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/39614.

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Alzeer, Samar Adnan. "Forensic toxicology of gamma hydroxybutyrate (GHB) metabolism." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16779.

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Lourens, Denise. "The epidemiology, pathology and toxicology of suicide." Master's thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/26780.

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Complete suicides and parasuicides are a major cause of death and disability in South Africa and the rest of the world. The epidemiology, pathology and toxicology of complete suicides were investigated in this study. All the complete suicide cases, which were presented to Salt River Medicolegal Laboratory over a period of one year (1 January 1997 - 31 December 1997), were analysed. The candidate personally conducted 148 of the alleged 180 suicide cases that presented in this time period (82%). The candidate did all the follow up investigations herself. The main findings were: 1. The male to fe

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35

Kristovich, Robert Lee. "Chemistry and toxicology of respirable airborne particulates." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1100898370.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 260 p.; also includes graphics (some col.). Includes bibliographical references (p. 242-260).

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Duffin, Roger. "Molecular toxicology studies on the quartz hazard." Thesis, Edinburgh Napier University, 2003. http://researchrepository.napier.ac.uk/Output/2777.

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Silicon makes up almost 28% of the Earth's crust and within that crust, quartz (crystalline silica) is one of the most abundant minerals. Exposure to quartz can occur in a number of occupations, including the mining and construction industries in which respirable quartz particles are generated and become airborne. Inhalation of quartz can lead to the fibrosing lung disease silicosis and cancer. Silicosis has been recognised for many decades as one of the most prevalent occupational lung diseases. In 1997, an IARC working Group classified quartz as a class 1 lung carcinogen, but only in some in

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37

Bordin, Diana Lilian. "Avaliação da genotoxicidade e estresse oxidativo em planárias aquáticas (Dugesia schubarti) tratadas com formulações do herbicida glifosato." reponame:Repositório Institucional da UCS, 2007. https://repositorio.ucs.br/handle/11338/480.

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Atualmente, diversas formulações de herbicidas a base de glifosato estão disponíveis no mercado. No entanto, diferentes surfactantes são também adicionados às formulações a fim de aumentar a eficácia do produto, o que pode contribuir significativamente para o aumento da toxicidade do herbicida aos organismos não alvos. Este estudo avaliou a genotoxicidade e o estresse oxidativo em planárias aquáticas (Dugesia schubarti) expostas às formulações de glifosato Roundup Original, Roundup Transorb e Roundup Ready. As planárias foram expostas à soluções de 0.5 mg/L de equivalente ácido de glifosato da

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Ferreira, Rafael Alexandre Costa [UNESP]. "Análise morfológica e histoquímica do corpo gorduroso e dos túbulos de Malpighi de operárias adultas de Scaptotrigona postica (Latreille, 1807) (Hymenoptera, Apidae) tratadas com fipronil e ácido bórico." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/87724.

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Made available in DSpace on 2014-06-11T19:22:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-30Bitstream added on 2014-06-13T20:10:19Z : No. of bitstreams: 1 ferreira_rac_me_rcla.pdf: 739935 bytes, checksum: 50907a1ee0174b4ffcbc2dde8cbd2c71 (MD5)<br>As abelhas contribuem para a manutenção das espécies vegetais no nicho ecológico onde vivem. Alguns compostos químicos encontrados em inseticidas utilizados na agricultura (fipronil), ou lançados no meio com resíduos industriais (ácido bórico) são tóxicos para as abelhas. Assim, objetivou-se avaliar a atividade tóxica desses composto

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Von, Woff Marya Anne. "Avaliação ecotoxicológica do antidepressivo cloridrato de fluoxetina." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267796.

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Orientador: Cassiana Maria Reganhan Coneglian<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Tecnologia<br>Made available in DSpace on 2018-08-17T21:32:28Z (GMT). No. of bitstreams: 1 VonWoff_MaryaAnne_M.pdf: 863495 bytes, checksum: 4548e40c4fa7eb23f789ab34f09fa155 (MD5) Previous issue date: 2011<br>Resumo: Fármacos para tratamento de distúrbios psíquicos estão entre as substancias ativas mais prescritas no mundo. A ocorrência destes em matrizes ambientais torna-se cada vez mais freqüente. Estudos recentes indicam que o fármaco cloridrato de fluoxetina, um inibid

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Maruo, Viviane Mayumi. "Estudo dos possíveis efeitos tóxicos da exposição à Solanum lycocarpum em ratos adultos e em sua prole." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-05022004-155718/.

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Solanum lycocarpum St. Hill é uma planta comum no cerrado brasileiro e possui um alcalóide com configuração estereoespecífica para a síntese de hormônios esteróides. O presente estudo foi desenvolvido para determinar os possíveis efeitos tóxicos da ingestão dos frutos de S. lycocarpum (3% adicionados à dieta) em ratos adultos machos (60 dias de administração), fêmeas (37 dias) e fêmeas prenhes (nos períodos de pré-implantação e organogênese). Poucas diferenças significantes no peso corpóreo e no consumo de água e ração foram observadas. Nenhuma diferença significante foi detectada no ganho

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Button, Mark. "Arsenic contaminated soils : human exposure and environmental toxicology." Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/7797.

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Burgess, Vanessa Anne, and n/a. "Toxicology Investigations With The Pectenotoxin-2 Seco Acids." Griffith University. School of Public Health, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030905.090222.

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Pectenotoxins (PTXs) are a group of large cyclic polyether compounds associated with diarrhetic shellfish poisoning (DSP) as they are often found in combination with other DSPs such as okadaic acid (OA) and dinophysis toxins (DTXs) in shellfish. Although classified and regulated with the DSPs, there is debate over whether these toxins should be classified with DSP toxins. To date, ten different analogues of PTXs have been identified from shellfish and algae, and of these, the pectenotoxin-2 seco acids (PTX2-SAs) are of particular interest as they have previously been implicated in a shellfish

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Verhagen, Franciscus Johannes Josephus. "Toxicology of the food additives BHA and BHT." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5479.

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Eiselen, Sue Catherine. "Neuropsychological toxicology a theoretical overview of neuropsychological assessment /." Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-10162007-133533.

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Small, Rowena Dianne. "The molecular toxicology of isoprene and its metabolites." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363859.

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Allen, Christopher N. "Cultured human gastrointestinal cell lines for predictive toxicology." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287261.

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Ismail, A. "Ecology and toxicology of arsenic in contaminated grassland." Thesis, University of Essex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376741.

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Antczak, Philipp. "Moving towards predictive toxicology - a systems biology approach." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3342/.

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Human health and the environment are at risk of being exposed to a large number of hazardous chemicals each day. Unfortunately, many of these chemicals have no or little recorded toxicity information. Predictive toxicology aims to provide tools and methodologies to address this issue. In combination with systems biology approaches these can provide a powerful toolbox for understanding the impact of chemicals on biological species. The work presented within this thesis demonstrates the effectiveness of such approaches in the context of industrial and environmentally relevant species. More speci

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Hughes, Sarah Jane Murty. "Towards deep-sea toxicology : experimental approaches with echinoderms." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/168893/.

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As anthropogenic activities expand into the deep sea, it is only recently that the importance of deep-sea ecosystems and processes to global biogeochemical systems has become clear. If the potential impact of human activity upon deep-sea organisms and ecosystems is to be understood and predicted, experimental studies are required to improve our knowledge of their sensitivity to contamination and disturbance. Echinoderms are integral components of deep-sea benthic communities and, by virtue of their abundance, they contribute significantly to deep-sea biogeochemical processes. As such, echinode

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Grabinski, Christin M. "NANOPARTICLE DEPOSITION AND DOSIMETRY FOR IN VITRO TOXICOLOGY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1428085283.

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