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Rozprawy doktorskie na temat „TREK1”

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Data publikacji: 6 września 2023
Data aktualizacji: 19 lipca 2025

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1

Walsh, Yvonne. "Pharmacological regulation of TREK1, TREK2 and TRESK two pore domain potassium channels." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/68081/.

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Introduction: Two pore domain potassium (K2P) channels are responsible for background currents that regulate membrane potential and neuronal excitability. Compounds which alter the activity of these channels are predicted to have therapeutic potential in treating CNS disorders. Members of the TREK family of K2P channels (TREK1 and TREK2) have been shown to play an active role in neuroprotection, depression and pain, whilst TRESK, with high expression in sensory neurons, has a role in nociception. Sipatrigine, a neuroprotective agent and a derivative of the anticonvulsant lamotrigine, is a know
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2

SATO, Jun, Kazue MIZUMURA, Ken TAKAHASHI, Kimiaki KATANOSAKA, and Yasuko KOZAKI. "Increased C-fiber Activities to Cold in Adjuvant-monoarthritic Rats was not Accompanied by Increased Expression of TREK1 and CMR1 mRNAs(RIEM Conference II, 2002)." Research Institute of Environmental Medicine, Nagoya University, 2002. http://hdl.handle.net/2237/2809.

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Dolcemascolo, Axel. "Laser à semi-conducteur pour modéliser et contrôler des cellules et des réseaux excitables." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4208/document.

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Les systèmes « excitables » sont omniprésents dans la nature, le plus paradigmatique d'entre eux étant le neurone, qui répond de façon « tout ou rien » aux perturbations externes. Cette particularité étant clairement établie comme l'un des points clé pour le fonctionnement des systèmes nerveux, son analyse dans des systèmes modèles (mathématiques ou physiques) peut d'une part aider à la compréhension de la dynamique d'ensembles de neurones couplés et d'autre part ouvrir des voies pour un traitement neuromimétique de l'information. C'est dans cette logique que s'inscrit la préparation de cette
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4

Schön, Anna. "Utopia Trek : utopibegreppets resa genom Star Trek." Thesis, Linköping University, Department of Thematic Studies, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2539.

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<p>Humanity has always dreamed about a better world. These dreams has manifested themselves in the vision of Utopia - the good place, but also the non-existing place. Up until World War II man still wrote optimistic descriptions of this ideal world, and spread the idea through literature. In the aftermath of the atomic bomb and under the influence of the cold war, these publications seized to surface in literary surroundings. Despite this utopia did not die - it has only changed. Today you can find utopia, not primarily in books, but in Science Fiction. TV’s biggest Science Fiction-series, Sta
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Geraghty, Lincoln. "Living with Star Trek : utopia, community, self-improvement and the Star Trek universe." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/10982/.

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Living with Star Trek investigates the connections between Star Trek fandom and the Star Trek text. This study identifies and examines the American themes of utopia, community and self-improvement inherent within the fictional text which also form the thematic framework for letters written by fans to express their affection for the series. These letters represent a `network of support', whereby a community of fans is able to communicate with each other through written correspondence sent to producers, edited collections, and fan magazines. In talking about the series, fans confess and share in
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6

Valverde, Estrella Lorena. "TREX1 and SAMHD1, and Aicardi-Goutières Syndrome." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/291940.

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Aicardi-Goutières Syndrome (AGS) is a rare encephalopathy which mimics a viral intrauterine infection and is characterized by calcifications of the basal ganglia, cerebral atrophy and IFN-a in the cerebrospinal fluid. AGS is a heterogenic disease associated with mutations in the gene of the exonuclease TREX1, in any of the genes codifying for the ribonuclease H2, in the phosphohydrolase SAMHD1, in the deaminase ADAR1 or in the cytoplasmic sensor MDA5. The knowledge of these functions is basic for the comprehension of the beginning of the pathogenesis of AGS. In this thesis we focused in the me
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7

Roy, André 1963. "Une lecture politique de Star trek /." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61800.

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8

Hawkey, Kate. "Beginning and becoming : a narrative trek." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684911.

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In chapter one I present a history and critique of the articles which comprise my PhD looking at each article in turn. There are two main sets of articles included and I set out how one area of interest developed into the next. The work focuses on the theme of mentoring and then history education. Together they represent my concern with a community of.practice within the history teaching profession. In chapter one I explain the contextual history in the development of my ideas and thinking between the articles and demonstrate how together they form a coherent whole. The chapter is presented as
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9

Lyons, Reneé C. "Trips and Treks: Teaching Endangered Species Through Literature." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/2367.

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10

Innamaa, Anni. "Expression and function of the two pore potassium (K2P) channels TREK-1, TREK-2 and TASK-3 in ovarian cancer." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606812.

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Aberrant expression of potassium (K+) channels contributes to cancer cell proliferation and in certain circumstances channel blockade has been shown to inhibit cell proliferation. Two pore potassium (K2P) channels are the most recently identified group of K+ channels. K2P channels have been found to play a role in several cancers including prostate and breast cancer. We investigated the K2P channels TREK-1, TREK-2 and TASK-3, in ovarian cancer and normal ovaries and described the effect of channel blockade on cell proliferation, the cell cycle and apoptosis. Immunofluorescence confirmed expres
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11

Karlsson, Torbjörn, and Gustav Ekholm. "Genusframställningen i Star Trek - en utopi eller dystopi?" Thesis, Halmstad University, School of Social and Health Sciences (HOS), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-528.

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<p>Titel: Genusframställningen i Star Trek – en utopi eller dystopi</p><p>Författare: Gustav Ekholm och Torbjörn Karlsson</p><p>Handledare: Malin Nilsson</p><p>Examinator: Veronica Stoehrel</p><p>Typ av arbete: C-uppsats i Medie och Kommunikationsvetenskap, 10p HT-06</p><p>Plats: Högskolan i Halmstad</p><p>Syfte: Uppsatsen syfte är att fastställa huruvida åtta olika avsnitt ur tv-serien Star Trek belyser genusfrågor och utmanar avsnitten i så fall de rådande genusdiskurserna.</p><p>Metod: Den här uppsatsen fokuserar på åtta Star Trek avsnitt som producerades mellan 1960-talet och 2000-tal
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12

Baker, Djoymi Anne. "Broadcast space : TV culture, myth and Star Trek /." Online version, 2005. http://bibpurl.oclc.org/web/21135.

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13

Haaren, April. "Power through gender in the star trek future /." Title page and introduction only, 2001. http://web4.library.adelaide.edu.au/theses/09AR/09arh1119.pdf.

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14

Laukkanen, Antti. "Volkswagen V-Trek : The Rise of Mental Transportation." Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149717.

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I started this project with a mindset that I want to design something for younger generations living in the future megacities. After a while, trying to figure out their urban mobility needs, I came to this conclusion: Already today we have so many different options for urban com- muting as well as several different car sharing services. I couldn’t find a way to create some- thing new. I changed my approach and I started thinking; what is it that they don’t have? I pret- ty soon understood it. They have no nature. By the year 2040, 70% of world’s population is expected to live in urban areas. T
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15

Villanueva, Mansilla Eduardo. "Star Trek: de lo transgeneracional al mundo multipolar." La Mirada de Telemo, 2009. http://repositorio.pucp.edu.pe/index//handle/123456789/20347.

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En mayo de este año se estrenó Star Trek, la más reciente película que tiene como tema las aventuras de la ficticia tripulación de la nave estelar Enterprise, situada en un futuro lejano e improbable pasado el año 2250; ejercicio de revitalización de una narrativa veterana. El éxito fue tanto en taquilla como en crítica, la que consideró como un logro que tras casi cuarenta y cinco años de su primera encarnación, se pudiera hacer una película entretenida que replanteaba por completo un conocido grupo de personajes y situaciones, sin por ello abandonar ni las formas ni el fondo de lo que
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16

Stoppe, Sebastian. "Zukunft im Spiel: Utopische Spielwelten bei Star Trek." Springer, 2020. https://ul.qucosa.de/id/qucosa%3A74214.

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Bei Star Trek mag man zunächst an die Fernsehserien und Kinofilme denken, jedoch nehmen auch Computerspiele einen nicht unerheblichen Raum in diesem Medienfranchise ein. Der Beitrag möchte anhand von drei Fallbeispielen kurz aufzeigen, wie sich das Serienuniversum von Star Trek mit seiner utopischen Idee im Medium Computerspiel fortsetzt und ob und inwiefern ein utopischer Text wie Star Trek in diesem Medium durch den Rezipienten nicht nur passiv-schauend, sondern auch aktiv-handelnd erfahrbar werden kann. Während das Spiel Birth of the Federation ein Globalstrategiespiel in den Stilen von Civ
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17

Elgenstierna, Saga. "Shakespeare bland stjärnorna : Litteraturens funktion i Star Trek." Thesis, Uppsala universitet, Litteraturvetenskapliga institutionen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447389.

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The television phenomenon called Star Trek has captured audiences for 55 years since the first episode was aired in 1966. In this essay, I study one aspect which has not been explored in detail before: How Star Trek uses literature in the five completed live action-series: Star Trek: The Original Series, Star Trek: The Next Generation, Star Trek: Deep Space Nine, Star Trek: Voyager and Star Trek: Enterprise. I explore this through adaptation studies, mainly as described and defined by Linda Hutcheon, and canon theory, as presented by Harold Bloom. In this essay, I answer my questions by watchi
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18

Pereira, Lopes Selma Patrícia. "Trex1 and Nbs1 as Regulators of the Macrophage Inflammatory Response." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/133008.

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Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabolism was conjectured to have a role in DNA damage repair and cancer. It was unexpected to find that Trex1-/- mice generated a few years later did not present increased cancer incidence but an inflammatory myocarditis that lead to premature death. Furthermore, TREX1 mutations were later associated to a number of different diseases that presented deregulation of the immune system, such as, SLE but also neurological defects in AGS. Nbs1 is a 95kDa protein and was first identified to it its intera
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19

Lyons, Reneé C. "Trips & Treks: Life Sustaining Expeditions Portrayed in Children’s Nonfiction." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/2385.

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Discover the stories of major natural science expeditions, as depicted in award-winning children's non-fiction. Examples include Robert Siebert award winner, Parrots over Puerto Rico, and Orbis Pictus winner, Quest for the Tree Kangaroo. While sharing Common Core correlations and reading promotion activities, participants explore how literature encurages children to care for and consider the natural world of which they are part.
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20

Wolf, Christine. "Dysregulierte DNA-Schadensantwort als Ursache von Autoinflammation und Autoimmunität bei TREX1-Defizienz." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-203730.

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Die vorliegenden Ergebnisse belegen eine essentielle Rolle der Beseitigung von intrazellulären DNA-Metaboliten aus der DNA-Reparatur für die Aufrechterhaltung von Immuntoleranz. So führt eine unangemessene Akkumulation körpereigener DNA im Zytosol, über die Erkennung durch Nukleinsäuresensoren, zu einer Aktivierung des angeborenen Immunsystems. Dies weist auf einen bisher unbekannten Zusammenhang zwischen DNA-Schäden, der DNA-Schadensantwort und einer Typ 1-IFN-vermittelten Aktivierung des angeborenen Immunsystems bei der Pathogenese von Autoimmunität hin.
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21

Porter, Chaya. "‘Engaging’ in Gender, Race, Sexuality and (dis)Ability in Science Fiction Television through Star Trek: the Next Generation and Star Trek: Voyager." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24209.

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As Richard Thomas writes, “there is nothing like Star Trek…Of all the universes of science fiction, the Star Trek universe is the most varied and extensive, and by all accounts the series is the most popular science fiction ever” (1). Ever growing (the latest Star Trek film will be released in Spring 2013) and embodied in hundreds of novels and slash fanfiction, decades of television and film, conventions, replicas, toys, and a complete Klingon language Star Trek is nothing short of a cultural phenomenon. As Harrison et al argue in Enterprise Zones: Critical Positions on Star Trek, the econom
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22

Grönberg, Anders, and Emanuel Lundberg. "Röda eller blå stjärnor : Politiska budskap i Star Trek." Thesis, Högskolan för lärande och kommunikation, Högskolan i Jönköping, HLK. Medie- och kommunikationsforskning, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-14407.

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Denna uppsats undersöker TV-serien Star Treks värderingar ur ett politiskt ideologiskt perspektiv. Star Trek är en amerikansk science fiction-serie som skapades av Gene Roddenberry i mitten av 1960-talet. Frågeställningarna behandlar om det finns politiskt relaterade värderingar framställda i Star Trek, vilken politisk ideologi som mest liknar värderingarna i serien, och om det går att tolka det som om Star Trek har en ideologisk värdegrund. Med hjälp av dagordningsteori, kritisk medieteori och teorier om budskap diskuteras TV-bolagens makt över seriens innehåll. De politiska ideologierna kon
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23

Bomark, David. "Den interplanetära rasismen : Star Trek Enterprise möte med världsrymden." Thesis, Södertörns högskola, Institutionen för kultur och kommunikation, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-16822.

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Denna studie vill undersöka om koloniala strukturer genomsyrar den senaste i raden av Star Trek-serierna, Enterprise. Med utgångspunkt i äldre forskning om just koloniala strukturer i Star Trek kommer en jämförelse göras om Enterprise först och främst har dessa strukturer och om så är fallet, göra en jämförelse med de andra serierna. Det postkoloniala forskningsfältet tillsammans med ett strukturalistiskt och post-strukturalistiskt tillvägagångssätt som innefattar semiotik och diskursanalys används för att kunna peka på hur de koloniala strukturerna genomsyrar serien. Analysen, som bland annat
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Stoppe, Sebastian. "„Tee, Earl Grey, heiß“: Star Trek und die technisierte Gesellschaft." LIT, 2008. https://ul.qucosa.de/id/qucosa%3A20899.

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Der Schöpfer der Science-Fiction-Serie Babylon 5 J. Michael Straczynski musste sich in einem Interview die Frage gefallen lassen, warum in seiner Serie die alltägliche Kommunikation noch über Handgeräte abgewickelt würde. Schließlich sei es doch heute allgemein akzeptiert, dass so genannte Kommunikatoren, die an die Brust geheftet werden, die vorherrschende Technologie der Zukunft sein werden. Diese Art von Technik, Kommunikatoren, tauchten zum ersten Mal 1987 in der Fernsehserie Star Trek: The Next Generation auf. In der Tat lösten sie in der Star Trek-Zeitlinie jene Handgeräte ab, die 1966 e
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Bernardi, Daniel. "Star trek and history : race-ing toward a white future /." New Brunswick, NJ [u.a.] : Rutgers University Press, 1999. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=018615232&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Roche, Christopher James. "Ornaments of the Desert : Springbok Treks in the Cape Colony, 1774-1908." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/6040.

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Kemp, John J. "Trek : a real time multi-player game for Xerox networked workstations /." Online version of thesis, 1990. http://hdl.handle.net/1850/10586.

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Musinszki, Marianne [Verfasser]. "Zellfreie Synthese und elektrophysiologische Charakterisierung von TREK K2P Kanälen / Marianne Musinszki." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1190086646/34.

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Bay, Katja [Verfasser], and Barbara [Akademischer Betreuer] Korte. "Im Spiegel der Zukunft: Wissenskultur und -ethik in Star Trek: Voyager." Freiburg : Universität, 2015. http://d-nb.info/1119327237/34.

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McKagen, Elizabeth Leigh. "Visions of Possibilities: (De)Constructing Imperial Narratives in Star Trek: Voyager." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/99063.

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In this dissertation, I argue that contemporary cultural narratives are infused with ongoing ideologies of Euro-American imperialism that prioritizes Western bodies and ways of engaging with living and nonliving beings. This restriction severely hinders possible responses to the present environmental crisis of the era often called the 'Anthropocene' through constant creation and recreation of imperial power relations and the presumed superiority of Western approaches to living. Taking inspiration from postcolonial theorist Edward Said and theories of cultural studies and empire, I use interdis
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31

Stoppe, Sebastian. "Ein perfekter Ort?: das utopische Element des Raumschiffs bei Star Trek." Meidenbauer, 2011. https://ul.qucosa.de/id/qucosa%3A20900.

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Ein wesentliches Charakteristikum der klassischen Utopieerzählungen der Renaissance ist, dass sie vor allem Raumutopien darstellen. Die Utopie ist an einem Wunschort angesiedelt, einer Imagination, die sich in zeitlicher Entfernung zum Betrachter befinden kann, die in jedem Fall aber eine beträchtliche räumliche Entfernung aufweist. Es scheint also eine Art Notwendigkeit zu bestehen, eine ideale Gesellschafts- respektive Staatsform in die topografische Peripherie zu verlegen, weitab von der real existierenden Gesellschaft, innerhalb derer die Utopie entstand. Nur so kann sich das Ideale frei v
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Stoppe, Sebastian. "Borg, Trills und weibliche Captains: Geschlechterkonzepte und Gender bei Star Trek." Leipziger Universitätsverlag, 2019. https://ul.qucosa.de/id/qucosa%3A38209.

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Über Jahrzehnte hinweg hat Star Trek weltweit einen nicht mehr wegzudenkenden Platz in der Populärkultur gefunden. Millionen von Menschen sind in den über 50 Jahren der Existenz Star Treks mit dem Franchise in der einen oder anderen Form in Berührung gekommen und haben ihrerseits die Rezeption der Serie geprägt. Man kann Star Trek über die gesamte Entwicklung hinweg als groß angelegte utopische Erzählung auffassen, die mit ihrem Bestehen die politische und soziale Entwicklung auf der Erde gespiegelt und als Ausgangspunkt ihrer Erzählungen genommen hat. Doch wie verhält es sich mit der Behandlu
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Van, Heerden Peter. "Trek : hitchhiking on the ox-wagon of destiny : voortrekker, draadtrekker, saamtrekker." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/15431.

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Includes bibliographical references (p. 61-64).<br>As a South African artist I am in power to influence some manner of change, through my art, to the structure of national thought and hence national identity. Through my live art installation TOTANDERKUNTUlT, I offered South Africans the opportunity to engage in the cathartic process of resolution and reconciliation through dialogue. The aim of this dialogue is to engender a new method of practice for a non-racialised approach to the development of an integrated cultural identity that South Africans can work towards. I am not proclaiming to hav
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Moreno, Sébastien. "Le récepteur 3 de la neurotensine/Sortiline dans la régulation de l’état dépressif." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4136/document.

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Le trouble dépressif majeur est une pathologie qui atteint 20% de la population et qui représente le premier facteur de morbidité et d’incapacité au niveau mondial. Récemment, le canal potassique TREK-1 est une cible potentielle avérée dans le traitement de la dépression. La délétion de ce canal ou son blocage par un peptide dérivé résultant de la maturation de la sortiline, le propeptide (PE) ou son analogue synthétique la Spadine, résulte en un phénotype de résistance à la dépression. La sortiline est une protéine capable de s’associer à TREK-1 mais également au facteur neurotrophique BDNF i
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Yuan, Fenghua, Tanmay Dutta, Ling Wang, et al. "Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/6537.

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3′ repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the antiviral response. In this work, we show that TREX1 is also a RNA exonuclease. Purified TREX1 displays robust exoribonuclease activity that degrades single-stranded, but not double-stranded, RNA. TREX1-D200N, an Aicardi-Goutieres syndrome disease-causing mutant, is defective in degrading RNA. TREX1 activity is strongly inhibited by a stretch of pyrimidine residues as is a bacterial homolog, RNase T. Kinetic measurements indicate that the apparent Km of TREX1 for RNA is higher than that for DNA.
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Merzbach, Sven. "Voortrekking Utopia geistesgeschichtliche Bezüge, soziokulturelle Phänomene, pädagogische Aspekte der Fernsehserie STAR TREK /." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975169203.

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McClenaghan, Conor. "Investigations into the structure, function and pharmacology of TREK K2P potassium channels." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:a4c57ac0-7710-40ba-bd07-77c8bd6bd831.

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TREK channels are polymodal potassium channels which act as integrators of diverse chemical and physical stimuli to dynamically control the cellular membrane potential. How the channels sense different stimuli, and how this is transduced to channel gating is not fully understood. Here I report the results of electrophysiological investigations into the structure-function relationship and pharmacology of TREK channels. Firstly, the mechanism of action of plant derived alkylamides at TREK-1 was found to be complex and assay-context dependent. Subsequent studies of TREK-2, guided by recent X-ray
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38

Belk, Fred Richard. "The great trek of the Russian mennonites to Central Asia, 1880-1884 /." Eugene (Or.) : Wipf and Stock publ, 2001. http://catalogue.bnf.fr/ark:/12148/cb39075227v.

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Rodrigues, Nuno. "Recherche et évaluation d'antalgiques originaux : les activateurs des canaux potassiques TREK-1." Thesis, Clermont-Ferrand 2, 2011. http://www.theses.fr/2011CLF22181.

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Les antalgiques utilisés aujourd’hui sont des produits anciens et plusieurs d’entre eux datent du 19ème siècle. La morphine demeure l’antalgique de référence pour les douleurs dites par excès de nociception, mais elle est à l’origine d’effets indésirables gênants et graves. Il a été démontré que l’effet antalgique de la morphine passait par l’activation des canaux potassiques TREK-1. Les travaux de recherche ont donc comme objectif la recherche d’antalgiques originaux activateurs de TREK-1. Nous avons synthétisé des activateurs de TREK-1 décrits dans la littérature puis nous avons évalué leur
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40

Hivelin, Céline. "Étude des mécanismes de libération du propeptide de la sortiline et de ses effets sur l’homéostasie glucidique." Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4109/document.

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En France, l’obésité touche 15% de la population et est en perpétuelle augmentation. Elle est une cause majeure du diabète de type 2. Elle se traduit par un accroissement du nombre de cellules de stockage du gras (adipocytes) et une résistance périphérique à l’insuline. Chez des individus obèses, l’augmentation du nombre d’adipocytes est associée à une diminution de l’expression de la sortiline, protéine transmembranaire dont le clivage entraine la formation du propeptide (PE) et sa libération dans la circulation sanguine. L’analogue synthétique du PE, la spadine, est connu pour moduler l’acti
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41

Recht, Marcus. "Homo artificialis eine Androiden & Cyborg Analyse mit dem Fokus auf Star Trek." Saarbrücken VDM, Müller, 2002. http://deposit.d-nb.de/cgi-bin/dokserv?id=2870182&prov=M&dok_var=1&dok_ext=htm.

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Houllou, Jean Raphael Zimmermann. "A multidão nos seriados Star Trek e Heroes: dissensos do imperialismo ao império." reponame:Repositório Institucional da UNISUL, 2016. http://www.riuni.unisul.br/handle/12345/2063.

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This thesis aims a critical reading of two American series also aired in Brazil: Star Trek and Heroes. The survey proposes to observe dissensus from the multitude present on both TV series. The multitude (HARDT; NEGRI, 2000) is a social force capable of challenging the sovereign power and to establish new forms of social organization, their presence may present dissensus (RANCIÈRE, 2010), new elements to what is conventionally considered and sense, the sensitive system already established. This movement is associated with materialistic conception of history that suggests seeking tensions again
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43

Stoppe, Sebastian. "Getting Immersed in Star Trek: Storytelling Between “True” and “False” on the Holodeck." Science Fiction Research Association, 2016. https://ul.qucosa.de/id/qucosa%3A20883.

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The holodeck in Star Trek is a device that creates a virtual, fictional reality that is virtually indistinguishable from actual reality. The user experiences an extremely high degree of immersion. The article explains what consequences arise when the boundaries between reality and fiction become blurred and the user can no longer distinguish between the two worlds.
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Vivier, Delphine. "Vers de nouveaux antalgiques : optimisation de molécules activatrices des canaux potassiques TREK-1." Thesis, Clermont-Ferrand 2, 2014. http://www.theses.fr/2014CLF22518/document.

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La morphine demeure l'antalgique de référence pour le traitement de la douleur (nociception), mais elle est également responsable d‘effets secondaires importants. Des études ont montré que les animaux privés de canaux potassiques TREK-1 (TWIK-related K+channels) étaient plus sensibles à la douleur. Plus récemment, il a été démontré que le canal potassique TREK-1 joue un rôle crucial dans l'analgésie induite par la morphine chez les souris, alors qu'il n'est pas impliqué dans les effets secondaires (constipation, dépression respiratoire et dépendance). Ces résultats suggèrent que les canaux TRE
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45

Pulliainen, M. (Mikael). "The character of Data and his humanity in Star Trek: The Next Generation." Bachelor's thesis, University of Oulu, 2018. http://urn.fi/URN:NBN:fi:oulu-201811103021.

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This study will aim to analyze the character Data, an android, in the television series Star Trek: The Next Generation. More specifically, this study will focus on Data’s humanity and sentience in the episode “The Measure of a Man”. Is Data sentient? Is he just a machine? Does he resemble humans based on his actions and interaction with the other characters? The methodology applied in this study is functional semiotic approach. I discovered that while Data is a machine and an artificial lifeform, he has many human-like characteristics and he learns them by observing humans and their actions, a
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46

Günther, Claudia, Michael Meurer, Annette Stein, Antje Viehweg, and Min-Ae Lee-Kirsch. "Familial Chilblain Lupus – A Monogenic Form of Cutaneous Lupus Erythematosus due to a Heterozygous Mutation in TREX1." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135462.

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Chilblain lupus erythematosus is a rare form of cutaneous lupus erythematosus characterized by bluish red infiltrates in acral locations of the body mostly affecting middle-aged women. We recently described a familial form of chilblain lupus manifesting in early childhood caused by a heterozygous mutation in the TREX1 gene, which encodes a 3′-5′ DNA exonuclease. Thus, familial chilblain lupus represents the first monogenic form of cutaneous lupus erythematosus. Here we describe the unusual clinical course of this newly defined genodermatosis in an 18-year-old female member of the family in whi
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47

Chen, Ming-Jiu. "Functional study to determine the role of TREX2 and TREX1 in maintaining genome integrity : a dissertation /." San Antonio : UTHSC, 2006. http://proquest.umi.com/pqdweb?did=1251820381&sid=3&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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48

O'Kane, Neil D. "TREK-1 investigation of a physiological role and identification of novel binding partner proteins /." abstract and full text PDF (UNR users only), 2009. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1472969.

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Ricks, McKenzie. "The measureable religious influence of participation in the Pioneer Trek Reenactment on young adults." Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1528032.

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<p> This study examined the measurable religious influence of participating in the Pioneer Trek Reenactment as an adolescent on young adults. A sample of 73 former Pioneer Trek Reenactment participants were surveyed. Both males and females were surveyed, and all respondents were between the ages of 18 and 35.</p><p> The results of this study may bring understanding to the impact of historical reenactment activities, such as the Pioneer Trek Reenactment, on their participants. The study showed how the participants' perception of the Pioneer Trek Reenactment from a religious, recreational, and
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50

Clemens-Smucker, Judith A. "Major Kira of Star Trek: DS9: Woman of the Future, Creation of the 90s." Bowling Green State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1601300905690302.

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