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Rozprawy doktorskie na temat „Trial Sequential Analysis”

Autor: Grafiati

Data publikacji: 4 czerwca 2025

Data aktualizacji: 1 sierpnia 2025

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CASTELLINI, GRETA. "INVESTIGATING INNOVATIVE EVIDENCE SYNTHESIS METHODS: THE TRIAL SEQUENTIAL ANALYSIS, THE GRADE SYSTEM AND THE NETWORK META-ANALYSIS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/672084.

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Le revisioni sistematiche e meta-analisi sono i migliori disegni di studio per assistere il processo decisionale in ambito clinico. Pazienti, clinici, ricercatori e decisori politici dovrebbero privilegiare la revisione sistematica rispetto a altri tipi di disegno sperimentale in quanto permette di aggregare diversi studi primari contemporaneamente, incrementando la validità interna ed esterna dei risultati. Inoltre, la meta-analisi aumenta la validità statistica raggiungendo più alti livelli di potenza statistica e precisione rispetto ai singoli studi. Ciò significa comprendere meglio la gra

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Schwimmbeck, Franz [Verfasser], and Leopold [Akademischer Betreuer] Eberhart. "Hypertone Kochsalzlösungen in der Therapie des Schädel-Hirn-Traumas und des traumatisch hämorrhagischen Schocks - Systematische Übersichtsarbeit und Metaanalyse mit Trial Sequential Analysis / Franz Schwimmbeck ; Betreuer: Leopold Eberhart." Marburg : Philipps-Universität Marburg, 2021. http://d-nb.info/1239239904/34.

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Todd, Susan Clare. "Methods of analysis for sequential clinical trials." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239477.

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Morgan, Caroline Claire. "Group sequential response adaptive designs for clinical trials." Thesis, University of Sussex, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288791.

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A recently developed group-sequential response-adaptive design to compare two treatments with immediate normally distributed responses and known variances is considered. The power function of the test is the same as that under non-adaptive sampling, and significant decreases in the inferior treatment number can be achieved with only minor increases in the average sample number. Reasonably accurate corrected confidence intervals for both the treatment mean difference and the individual means are obtained by constructing approximately pivotal quantities. An approximation to the bias of the maxim

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Blatchford, Patrick Judson. "Monitoring bivariate endpoints in group sequential clinical trials /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biostatistics) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 104-106). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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Facey, Karen Maria. "Sequential procedures for clinical trials design, monitoring and analysis." Thesis, University of Reading, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315536.

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Rojas, Cordova Alba Claudia. "Resource Allocation Decision-Making in Sequential Adaptive Clinical Trials." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/86348.

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Adaptive clinical trials for new drugs or treatment options promise substantial benefits to both the pharmaceutical industry and the patients, but complicate resource allocation decisions. In this dissertation, we focus on sequential adaptive clinical trials with binary response, which allow for early termination of drug testing for benefit or futility at interim analysis points. The option to stop the trial early enables the trial sponsor to mitigate investment risks on ineffective drugs, and to shorten the development time line of effective drugs, hence reducing expenditures and expediting p

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Öhrn, Carl Fredrik. "Group sequential and adaptive methods : topics with applications for clinical trials." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538283.

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This thesis deals with sequential and adaptive methods for clinical trials, and how such methods can be used to achieve efficient clinical trial designs. The efficiency gains that can be achieved through non-adaptive group sequential methods are well established, while the newer adaptive methods seek to combine the best of the classical group sequential framework with an approach that gives increased flexibility. Our results show that the adaptive methods can provide some additional efficiency, as well as increased possibilities to respond to new internal and external information. Care is howe

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Gillen, Daniel L. "The use of weighted logrank statistics in group sequential testing and non-proportional hazards /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/9557.

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Alharbi, Ghaleb. "Evidence-based medicine in neuropathic pain : a systematic review, meta-analysis, sequential analysis and network meta-analysis of randomised controlled trials." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/55427/.

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Background Many randomised controlled trials (RCTs) are available to support using different pharmacotherapy agents in the management of various neuropathic pain conditions. However, choosing these pharmacotherapy agents for neuropathic pain is challenging, due to the limited evidence-based knowledge to support the use of different pharmacotherapy agents in different neuropathic pain conditions. Aims The aim of this PhD is to evaluate the efficacy and safety of oral and topical pharmacotherapies for managing neuropathic pain by deriving placebo and active comparative efficacy and safety eviden

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Chien, Hung-Ken, and 簡宏根. "An Economic Analysis of Sequential Trial and Unitary Trial." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/71596018577082787967.

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Zhong, Xiaobo. "Design and Analysis of Sequential Multiple Assignment Randomized Trial for Comparing Multiple Adaptive Interventions." Thesis, 2018. https://doi.org/10.7916/D8DJ6Z1K.

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The research of my dissertation studies the methods of designing and analyzing sequential multiple assignment randomized trial (SMART) for comparing multiple adaptive interventions. As a SMART typically consists of numerous adaptive interventions, inferential procedures based on pairwise comparisons of all interventions may suffer substantial loss in power after accounting for multiplicity. I address this problem using two approaches. First, I propose a likelihood-based Wald test, study the asymptotic distribution of its test statistics, and apply it as a gate-keeping test for making an adapti

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TSAI, YU-JUI, and 蔡育睿. "Association between Vitamin D Receptor Gene Polymorphism and Osteoporosis through Trial Sequential Analysis: Case Control Study and Meta- Analysis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/cq8848.

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碩士<br>國防醫學院<br>公共衛生學研究所<br>107<br>Introduction The proportion of elderly people aged over 65 in Taiwan has reached 13.9% in the end of 2017. The aging of the population will lead to the increase of chronic diseases such as osteoporosis, which is an important public health issue. Therefore, this study first search the meta- analysis of osteoporosis and gene polymorphism, and used trial sequential analysis to explore whether these SNPs provided by the above article can be affirmed with evidence. Among them, one of SNPs called VDR ApaI still has insufficient evidence, therefore, we first use the

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WANG, YU-CHIAO, and 王昱喬. "Association between Estrogen receptor 1 Gene Polymorphism and Osteoarthritis through Trial Sequential Analysis: Case Control Study and Meta-analysis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/c7tque.

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碩士<br>國防醫學院<br>公共衛生學研究所<br>107<br>Introduction: Genes play an important role in osteoarthritis (OA). Although there are 80 gene-related papers to investigate the study of polymorphism and osteoarthritis, there are many different opinions in the same gene. However, the results of the study are inconsistent, and no study indicates whether the cumulative number of samples is enough. Therefore, the Trial Sequential Analysis (TSA) of this study verifies whether the cumulative number of samples at the locus has reached a certain conclusion, no need to invest more resources. Materials and methods: Th

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Pond, Gregory Russell. "Design and Analysis of Sequential Clinical Trials using a Markov Chain Transition Rate Model with Conditional Power." Thesis, 2008. http://hdl.handle.net/1807/11245.

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Background: There are a plethora of potential statistical designs which can be used to evaluate efficacy of a novel cancer treatment in the phase II clinical trial setting. Unfortunately, there is no consensus as to which design one should prefer, nor even which definition of efficacy should be used and the primary endpoint conclusion can vary depending on which design is chosen. It would be useful if an all-encompassing methodology was possible which could evaluate all the different designs simultaneously and allow investigators an understanding of the trial results under the varying scenario

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Yao, Baiyun. "Bayesian approaches for the analysis of sequential parallel comparison design in clinical trials." Thesis, 2018. https://hdl.handle.net/2144/33052.

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Placebo response, an apparent improvement in the clinical condition of patients randomly assigned to the placebo treatment, is a major issue in clinical trials on psychiatric and pain disorders. Properly addressing the placebo response is critical to an accurate assessment of the efficacy of a therapeutic agent. The Sequential Parallel Comparison Design (SPCD) is one approach for addressing the placebo response. A SPCD trial runs in two stages, re-randomizing placebo patients in the second stage. Analysis pools the data from both stages. In this thesis, we propose a Bayesian approach for analy

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