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Artykuły w czasopismach na temat „Trial Sequential Analysis”

Autor: Grafiati

Data publikacji: 4 czerwca 2025

Data aktualizacji: 1 sierpnia 2025

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1

Leonardi-Bee, J. "Trial Sequential Analysis." International Journal of Evidence-Based Healthcare 14, no. 4 (2016): 194. http://dx.doi.org/10.1097/01.xeb.0000511335.64918.e6.

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Yang, Shengping, and Gilbert Berdine. "Trial sequential analysis." Southwest Respiratory and Critical Care Chronicles 11, no. 47 (2023): 63–67. http://dx.doi.org/10.12746/swrccc.v11i47.1175.

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Chai-Adisaksopha, Chatree, Kristian Thorlund, and Alfonso Iorio. "Interpreting trial sequential analysis." Transfusion 56, no. 12 (2016): 2918–22. http://dx.doi.org/10.1111/trf.13910.

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Kang, Hyun. "Trial sequential analysis: novel approach for meta-analysis." Anesthesia and Pain Medicine 16, no. 2 (2021): 138–50. http://dx.doi.org/10.17085/apm.21038.

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Systematic reviews and meta-analyses rank the highest in the evidence hierarchy. However, they still have the risk of spurious results because they include too few studies and participants. The use of trial sequential analysis (TSA) has increased recently, providing more information on the precision and uncertainty of meta-analysis results. This makes it a powerful tool for clinicians to assess the conclusiveness of meta-analysis. TSA provides monitoring boundaries or futility boundaries, helping clinicians prevent unnecessary trials. The use and interpretation of TSA should be based on an und

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Barakji, Jehad, Steven Kwasi Korang, Joshua Feinberg, et al. "Cannabinoids versus placebo for pain: A systematic review with meta-analysis and Trial Sequential Analysis." PLOS ONE 18, no. 1 (2023): e0267420. http://dx.doi.org/10.1371/journal.pone.0267420.

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Objectives To assess the benefits and harms of cannabinoids in participants with pain. Design Systematic review of randomised clinical trials with meta-analysis, Trial Sequential Analysis, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Data sources The Cochrane Library, MEDLINE, Embase, Science Citation Index, and BIOSIS. Eligibility criteria for selecting studies Published and unpublished randomised clinical trials comparing cannabinoids versus placebo in participants with any type of pain. Main outcome measures All-cause mortality, pain, adverse e

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Al-Rudayni, Ali Hatem Manfi, Divya Gopinath, Mari Kannan Maharajan, Sajesh K. Veettil, and Rohit Kunnath Menon. "Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis." International Journal of Environmental Research and Public Health 18, no. 14 (2021): 7418. http://dx.doi.org/10.3390/ijerph18147418.

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Oral mucositis is a debilitating complication of chemotherapy, characterized by erythema, ulcers and oedema of the oral mucosa. This review aimed to evaluate the efficacy of Photobiomodulation in the treatment of oral mucositis using meta-analysis and trial sequential analysis, and also to assess the quality of the results by Grading of Recommendations, Assessment, Development and Evaluation (GRADE). A comprehensive search of three databases, including Embase, Medline and Central, was performed to identify randomized controlled trials studying the efficacy of Photobiomodulation in the treatmen

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Alfirevic, Z., and S. Gates. "Trial sequential analysis: useful or useless?" BJOG: An International Journal of Obstetrics & Gynaecology 127, no. 10 (2020): 1227–28. http://dx.doi.org/10.1111/1471-0528.16282.

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Kulinskaya, Elena, and John Wood. "Trial sequential methods for meta-analysis." Research Synthesis Methods 5, no. 3 (2013): 212–20. http://dx.doi.org/10.1002/jrsm.1104.

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Geller, N. L. "Planned interim analysis and its role in cancer clinical trials." Journal of Clinical Oncology 5, no. 9 (1987): 1485–90. http://dx.doi.org/10.1200/jco.1987.5.9.1485.

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Although interim analyses in cancer clinical trials are commonplace, clinical trials are usually designed with the implicit assumption that data analysis will occur only after the trial is completed. The design of randomized trials with planned interim analyses, "group sequential trials," is described and examples are given. A method to redesign trials in which unplanned interim analyses have been undertaken is described. Planned interim analysis should be considered whenever a cancer clinical trial is designed.

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Maurya, Indubala, Ayush Lohiya, and Ashish Solanki. "Trial sequential analysis: Quality improvement for meta-analysis." Indian Journal of Anaesthesia 68, no. 12 (2024): 1092–94. https://doi.org/10.4103/ija.ija_1051_24.

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Juul, Sophie, Emil Eik Nielsen, Joshua Feinberg, et al. "Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)." PLOS ONE 16, no. 3 (2021): e0248132. http://dx.doi.org/10.1371/journal.pone.0248132.

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Background COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. This is the second edition of a living systematic review of randomized clinical trials assessing the effects of all treatment interventions for participants in all age groups with COVID-19. Methods and findings We planned to conduct aggregate data meta-analyses, trial sequential analyses, network meta-analysis, and individual patient data meta-analyses. Our systematic review was based on PRISMA and Cochrane

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NeCamp, Timothy, Amy Kilbourne, and Daniel Almirall. "Comparing cluster-level dynamic treatment regimens using sequential, multiple assignment, randomized trials: Regression estimation and sample size considerations." Statistical Methods in Medical Research 26, no. 4 (2017): 1572–89. http://dx.doi.org/10.1177/0962280217708654.

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Cluster-level dynamic treatment regimens can be used to guide sequential treatment decision-making at the cluster level in order to improve outcomes at the individual or patient-level. In a cluster-level dynamic treatment regimen, the treatment is potentially adapted and re-adapted over time based on changes in the cluster that could be impacted by prior intervention, including aggregate measures of the individuals or patients that compose it. Cluster-randomized sequential multiple assignment randomized trials can be used to answer multiple open questions preventing scientists from developing

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Lin, Jin-Wei, Chung-Ting Chen, Ming-Shun Hsieh, et al. "Percutaneous catheter drainage versus percutaneous needle aspiration for liver abscess: a systematic review, meta-analysis and trial sequential analysis." BMJ Open 13, no. 7 (2023): e072736. http://dx.doi.org/10.1136/bmjopen-2023-072736.

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ObjectiveTo compare the effectiveness and safety of percutaneous catheter drainage (PCD) against percutaneous needle aspiration (PNA) for liver abscess.DesignSystematic review, meta-analysis and trial sequential analysis.Data sourcesPubMed, Web of Science, Cochrane Library, Embase, Airiti Library and ClinicalTrials.gov were searched from their inception up to 16 March 2022.Eligibility criteriaRandomised controlled trials that compared PCD to PNA for liver abscess were considered eligible, without restriction on language.Data extraction and synthesisPrimary outcome was treatment success rate. D

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Taylor, Paul Geoffrey, Kwee-Yum Lee, Raul Landeo, Damien Michael O'Meara, and Emma Millett. "Determining optimal trial size using sequential analysis." Journal of Sports Sciences 33, no. 3 (2014): 300–308. http://dx.doi.org/10.1080/02640414.2014.942679.

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Christensen, Erik. "Effective randomized clinical trial design: sequential analysis." Journal of Hepatology 38, no. 4 (2003): 550–51. http://dx.doi.org/10.1016/s0168-8278(03)00048-5.

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Xu Duan-Zheng and Shi Jun. "Computers: Computer analysis of the sequential trial." Trends in Pharmacological Sciences 7 (January 1986): 258–59. http://dx.doi.org/10.1016/0165-6147(86)90343-3.

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Koretz, Ronald L. "JPEN Journal Club 50. Trial Sequential Analysis." Journal of Parenteral and Enteral Nutrition 44, no. 4 (2020): 729–32. http://dx.doi.org/10.1002/jpen.1753.

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Flynn, Darren, Richard Francis, Kristoffer Halvorsrud, et al. "Intra-arterial mechanical thrombectomy stent retrievers and aspiration devices in the treatment of acute ischaemic stroke: A systematic review and meta-analysis with trial sequential analysis." European Stroke Journal 2, no. 4 (2017): 308–18. http://dx.doi.org/10.1177/2396987317719362.

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Purpose Intra-arterial mechanical thrombectomy combined with appropriate patient selection (image-based selection of acute ischaemic stroke patients with large artery occlusion) yields improved clinical outcomes. We conducted a systematic review and meta-analysis, with trial sequential analysis to understand the benefits, risks and impact of new trials reporting in 2016 on the magnitude/certainty of the estimates for clinical effectiveness and safety of mechanical thrombectomy. Method Random effects’ models were conducted of randomised clinical trials comparing mechanical thrombectomy (stent r

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Nair, Abhijit, and Nitin K. Borkar. "Understanding the trial sequential analysis graph in meta-analysis." Saudi Journal of Anaesthesia 18, no. 1 (2024): 162–64. http://dx.doi.org/10.4103/sja.sja_715_23.

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Miladinovic, Branko, Ambuj Kumar, Rahul Mhaskar, Helen Mahoney, Keith Wheatley, and Benjamin Djulbegovic. "Trial Sequential Analysis in Meta-Analyses of Maintenance Therapies for Multiple Myeloma." Blood 120, no. 21 (2012): 2975. http://dx.doi.org/10.1182/blood.v120.21.2975.2975.

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Abstract Abstract 2975 Background: Meta-analyses (MAs) with few participants (i.e. small number of primary studies) are at risk of producing random errors and consequently overestimating treatment effects. With insufficient information the risk of obtaining a false positive result (type I error) increases, which may lead to false conclusions. Trial sequential analysis (TSA) has been proposed as a method to ascertain whether results of MAs are conclusive (true vs. false positive, true vs. false negative). It adjusts for the risk of random error by constructing monitoring boundaries under the sa

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Grayling, Michael J., James MS Wason, and Adrian P. Mander. "Group sequential designs for stepped-wedge cluster randomised trials." Clinical Trials 14, no. 5 (2017): 507–17. http://dx.doi.org/10.1177/1740774517716937.

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Background/Aims: The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design of stepped-wedge cluster randomised trials with interim analyses. In an individually randomised trial setting, group sequential methods can provide notable efficiency gains and ethical benefits. We address this by discussing how established group sequential methodology can be adapted for stepped-wedge designs. Methods: Utilising the error spending approach to group seq

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Yoder, Whitney, Floris Groenendaal, Wes Onland, Anna van Oploo, Charlotte Rietbergen, and Rolf Groenwold. "Sequential co-enrolment in randomised trials in neonatal intensive care medicine." Archives of Disease in Childhood - Fetal and Neonatal Edition 105, no. 2 (2019): 128–31. http://dx.doi.org/10.1136/archdischild-2019-316818.

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In many medical research settings, such as the neonatal intensive care unit, the number of patients who are eligible for a randomised clinical trial is relatively small and recruiting a sufficient number of patients into trials is often difficult. Furthermore, some infants may have already been enrolled into a trial as a fetus. Sequential co-enrolment of patients into more than one trial may offer a solution, yet runs the risk of contaminated results. We consider the situation of two sequential trials and describe requirements for different possible treatments effects (‘estimands’) to be estim

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Maratea, Dario, Valeria Fadda, Sabrina Trippoli, and Andrea Messori. "Glutamine in critically ill patients: Trial-sequential analysis." Clinical Nutrition 33, no. 4 (2014): 735–36. http://dx.doi.org/10.1016/j.clnu.2014.02.004.

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Shah, A., and A. F. Smith. "Trial sequential analysis: adding a new dimension to meta‐analysis." Anaesthesia 75, no. 1 (2019): 15–20. http://dx.doi.org/10.1111/anae.14705.

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Tan, Nannan, Yiqing Cai, Junjie Liu, et al. "Effects and Safety of Oral Iron for Heart Failure with Iron Deficiency: A Systematic Review and Meta-Analysis with Trial Sequential Analysis." Cardiovascular Therapeutics 2022 (September 17, 2022): 1–16. http://dx.doi.org/10.1155/2022/6442122.

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Background. Oral iron supplement is commonly prescribed to heart failure patients with iron deficiency. However, the effects of oral iron for heart failure remain controversial. This study included randomized controlled trials (RCTs) for meta-analysis to evaluate the effects of oral iron for heart failure patients. Methods. Nine databases (The Cochrane Library, Embase, PubMed, CINAHL, Web of science, CNKI, SinoMed, VIP, and Wanfang) were searched for RCTs of oral iron for heart failure from inception to October 2021. The effects were assessed with a meta-analysis using Revman 5.3 software. The

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Al-Rudayni, Ali Hatem Manfi, Divya Gopinath, Mari Kannan Maharajan, Sajesh Kalkandi Veettil, and Rohit Kunnath Menon. "Efficacy of Oral Cryotherapy in the Prevention of Oral Mucositis Associated with Cancer Chemotherapy: Systematic Review with Meta-Analysis and Trial Sequential Analysis." Current Oncology 28, no. 4 (2021): 2852–67. http://dx.doi.org/10.3390/curroncol28040250.

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Background: This review aimed to evaluate the efficacy of oral cryotherapy in the prevention of chemotherapy-induced oral mucositis using meta-analysis and trial sequential analysis, as well as to assess the quality of the results by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Methods: A comprehensive search of three databases including Medline, Embase and Central was performed to identify randomized controlled trials that used oral cryotherapy for the prevention of chemotherapy-induced oral mucositis. The primary outcome was the incidence of oral m

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Xu, Chongxi, Tong Yi, Siwen Tan, et al. "Association of Oral or Intravenous Vitamin C Supplementation with Mortality: A Systematic Review and Meta-Analysis." Nutrients 15, no. 8 (2023): 1848. http://dx.doi.org/10.3390/nu15081848.

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Mortality is the most clinically serious outcome, and its prevention remains a constant struggle. This study was to assess whether intravenous or oral vitamin C (Vit-C) therapy is related to reduced mortality in adults. Data from Medline, Embase, and the Cochrane Central Register databases were acquired from their inception to 26 October 2022. All randomized controlled trials (RCTs) involving intravenous or oral Vit-C against a placebo or no therapy for mortality were selected. The primary outcome was all-cause mortality. Secondary outcomes were sepsis, COVID-19, cardiac surgery, noncardiac su

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Flight, Laura, Steven Julious, Alan Brennan, and Susan Todd. "Expected Value of Sample Information to Guide the Design of Group Sequential Clinical Trials." Medical Decision Making 42, no. 4 (2021): 461–73. http://dx.doi.org/10.1177/0272989x211045036.

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Introduction Adaptive designs allow changes to an ongoing trial based on prespecified early examinations of accrued data. Opportunities are potentially being missed to incorporate health economic considerations into the design of these studies. Methods We describe how to estimate the expected value of sample information for group sequential design adaptive trials. We operationalize this approach in a hypothetical case study using data from a pilot trial. We report the expected value of sample information and expected net benefit of sampling results for 5 design options for the future full-scal

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Zhang, Yang, Qiong Xu, Feng Zhang, and Chunlei Sun. "Probiotics for Preventing Necrotizing Enterocolitis: A Meta-Analysis with Trial Sequential Analysis." Journal of Clinical Pharmacy and Therapeutics 2023 (May 8, 2023): 1–15. http://dx.doi.org/10.1155/2023/8626191.

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What is Known and Objective. The role of probiotics, especially the different genera of probiotics, in managing necrotizing enterocolitis (NEC) is controversial. Thus, we performed a meta-analysis with trial sequential analysis (TSA) to determine the efficacy and safety of probiotics for preventing NEC. Methods. Medline, Embase, CENTRAL, WorldCat, TROVE, DART-Europe, and CBM were searched from inception to May 2022. Two investigators independently screened the literature, extracted data, and assessed the quality of the included studies. Meta-analysis was performed using RevMan 5.4, and TSA was

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Wang, Xiaoqin, Liang Yao, Long Ge, et al. "Pharmacological interventions for preventing post-operative atrial fibrillation in patients undergoing cardiac surgery: a network meta-analysis protocol." BMJ Open 7, no. 12 (2017): e018544. http://dx.doi.org/10.1136/bmjopen-2017-018544.

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IntroductionPostoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, and randomised clinical trials (RCTs) and systematic reviews have been conducted to compare and evaluate different pharmacological interventions for preventing POAF. This study aimed to explore the effect of different pharmacological interventions for prophylaxis against POAF after cardiac surgery using network meta-analysis (NMA).Methods and analysisA systematic search will be performed in PubMed, EMBASE and the Cochrane Library to identify RCTs, systematic reviews, meta-analyses or

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Wei, Li, Hui Han, Jie Meng, Xin Li, and Qing-Ping Yao. "Meta-analysis and sequential analysis of acupuncture compared to carbamazepine in the treatment of trigeminal neuralgia." World Journal of Clinical Cases 12, no. 22 (2024): 5083–93. http://dx.doi.org/10.12998/wjcc.v12.i22.5083.

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BACKGROUND In this randomized controlled trial (RCT) comparing current acupuncture with carbamazepine for trigeminal neuralgia, meta- and sequential analyses were utilized. AIM To guide clinical decision making regarding the treatment of trigeminal neuralgia with carbamazepine. METHODS The RCT literature on needle comparison was searched in various Chinese biomedical databases including Chinese Biomedical Literature Database, Wanfang Data, VIP Database, as well as international databases such as Excerpt Medica Database, Cochrane Library, PubMed, and Web of Science, along with related clinical

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Jalalzadeh, Hasti, Allard S. Timmer, Dennis R. Buis, et al. "Triclosan-Containing Sutures for the Prevention of Surgical Site Infection." JAMA Network Open 8, no. 3 (2025): e250306. https://doi.org/10.1001/jamanetworkopen.2025.0306.

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ImportanceInternational guidelines recommend the use of triclosan-containing sutures for the prevention of surgical site infections. However, controversy still remains about triclosan-containing suture use in clinical practice since several new randomized clinical trials (RCTs) have shown contradicting results.ObjectiveTo update a previous systematic review and meta-analysis of the association of triclosan-containing sutures with surgical site infections and explore the potential added value of new RCTs.Data SourcesPubMed, Embase, and Cochrane CENTRAL databases were searched from January 1, 20

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Messori, Andrea, Valeria Fadda, Dario Maratea, and Sabrina Trippoli. "Maintenance Chemotherapy in Ovarian Cancer: A Trial-Sequential Analysis." Journal of Cancer Therapy 04, no. 07 (2013): 1242–43. http://dx.doi.org/10.4236/jct.2013.47145.

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Chan, Jeffrey Shi Kai, and Dawnie Ho Hei Lau. "Does lysing make life better? A trial sequential analysis." Journal of Neurology 267, no. 6 (2020): 1842–45. http://dx.doi.org/10.1007/s00415-020-09801-8.

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Krogh, Jesper, Carsten Hjorthøj, Helene Speyer, Christian Gluud, and Merete Nordentoft. "Exercise for patients with major depression: a systematic review with meta-analysis and trial sequential analysis." BMJ Open 7, no. 9 (2017): e014820. http://dx.doi.org/10.1136/bmjopen-2016-014820.

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ObjectivesTo assess the benefits and harms of exercise in patients with depression.DesignSystematic reviewData sourcesBibliographical databases were searched until 20 June 2017.Eligibility criteria and outcomesEligible trials were randomised clinical trials assessing the effect of exercise in participants diagnosed with depression. Primary outcomes were depression severity, lack of remission and serious adverse events (eg, suicide) assessed at the end of the intervention. Secondary outcomes were quality of life and adverse events such as injuries, as well as assessment of depression severity a

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Maclaren, Robert, Sterling Torian, Tyree Kiser, Scott Mueller, and Paul Reynolds. "Therapeutic Hypothermia Following Cardiopulmonary Arrest: A Systematic Review and Meta-Analysis with Trial Sequential Analysis." Journal of Critical Care Medicine 9, no. 2 (2023): 64–72. http://dx.doi.org/10.2478/jccm-2023-0015.

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ABSTRACT Introduction The risk-benefit profile of therapeutic hypothermia is controversial with several randomized controlled trials providing conflicting results. Aim of Study The purpose of this systematic review and meta-analysis was to determine if therapeutic hypothermia provides beneficial neurologic outcomes relative to adverse effects. Material and Methods MEDLINE and EMBASE databases were searched for randomized controlled trials of post-cardiac arrest patients comparing therapeutic hypothermia (~33 degrees Celsius) to normothermia or the standard of care (36 - 38 degrees Celsius). Da

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Jin, Zhaosheng, Thomas Durrands, Ru Li, Tong Joo Gan, and Jun Lin. "Pectoral block versus paravertebral block: a systematic review, meta-analysis and trial sequential analysis." Regional Anesthesia & Pain Medicine 45, no. 9 (2020): 727–32. http://dx.doi.org/10.1136/rapm-2020-101512.

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BackgroundPectoral (PECs) block was first described by Blanco et al for postoperative analgesia in breast surgery. It was proposed to be an easier and safer alternative to thoracic epidural or paravertebral block (PVB). In this systematic review and meta-analysis, we compare the perioperative analgesic efficacy and adverse events of PECs block and PVB.MethodsWe systematically searched PubMed, Central, EMBASE, CINAHL, Google Scholar, Web of Science citation index, US clinical trials register, Wanfang database, as well as recent conference abstracts, for clinical studies comparing the two techni

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Early, Jonathan, Jessica Aalders, Elizabeth Arnott, Claire Wade, and Paul McGreevy. "Sequential Analysis of Livestock Herding Dog and Sheep Interactions." Animals 10, no. 2 (2020): 352. http://dx.doi.org/10.3390/ani10020352.

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Livestock herding dogs are crucial contributors to Australian agriculture. However, there is a dearth of empirical studies of the behavioural interactions between dog and livestock during herding. A statistical approach that may reveal cause and effect in such interactions is lag sequential analysis. Using 48 video recordings of livestock herding dogs and sheep in a yard trial competition, event-based (time between behaviours is irrelevant) and time-based (time between behaviours is defined) lag sequential analyses identified several significant behavioural interactions (adjusted residuals gre

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Mütze, Tobias, Ekkehard Glimm, Heinz Schmidli, and Tim Friede. "Group sequential designs with robust semiparametric recurrent event models." Statistical Methods in Medical Research 28, no. 8 (2018): 2385–403. http://dx.doi.org/10.1177/0962280218780538.

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Robust semiparametric models for recurrent events have received increasing attention in the analysis of clinical trials in a variety of diseases including chronic heart failure. In comparison to parametric recurrent event models, robust semiparametric models are more flexible in that neither the baseline event rate nor the process inducing between-patient heterogeneity needs to be specified in terms of a specific parametric statistical model. However, implementing group sequential designs in the robust semiparametric model is complicated by the fact that the sequence of Wald statistics does no

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Miksad, Rebecca A., Mithat Gönen, Thomas J. Lynch, and Thomas G. Roberts. "Interpreting Trial Results in Light of Conflicting Evidence: A Bayesian Analysis of Adjuvant Chemotherapy for Non–Small-Cell Lung Cancer." Journal of Clinical Oncology 27, no. 13 (2009): 2245–52. http://dx.doi.org/10.1200/jco.2008.16.2586.

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PurposeWhen successive randomized trials contradict prior evidence, clinicians may be unsure how to evaluate them: Does accumulating evidence warrant changing practice? An increasingly popular solution, Bayesian statistics quantitatively evaluate new results in context. This study provides a clinically relevant example of Bayesian methods.MethodsThree recent non–small-cell lung cancer adjuvant chemotherapy trials were evaluated in light of prior conflicting data. Results were used from International Adjuvant Lung Trial (IALT), JBR.10, and Adjuvant Navelbine International Trialist Association (

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Petersen, Johanne Juul, Caroline Barkholt Kamp, Pascal Faltermeier, et al. "Deep brain stimulation for Parkinson’s disease: systematic review with meta-analysis and trial sequential analysis." BMJ Medicine 3, no. 1 (2024): e000705. http://dx.doi.org/10.1136/bmjmed-2023-000705.

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ObjectiveTo assess the benefits and harms of deep brain stimulation for Parkinson’s disease.DesignSystematic review with meta-analysis and trial sequential analysis.Data sourcesCochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, Latin American and Caribbean Health Sciences Literature (LILACS), and other sources, from inception to 9 May 2023.Eligibility criteria for selecting studiesRandomised clinical trials of deep brain stimulation with antiparkinsonian drug treatment use versus antiparkinsonian drugs only (primary comparison, seven trials) for Parkinson’s disease. Oth

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Jakobsen, J. C., J. L. Hansen, S. Simonsen, E. Simonsen, and C. Gluud. "Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder: a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses." Psychological Medicine 42, no. 7 (2011): 1343–57. http://dx.doi.org/10.1017/s0033291711002236.

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BackgroundMajor depressive disorder afflicts an estimated 17% of individuals during their lifetime at tremendous suffering and cost. Cognitive therapy and interpersonal psychotherapy are treatment options, but their effects have only been limitedly compared in systematic reviews.MethodUsing Cochrane systematic review methodology we compared the benefits and harm of cognitive therapy versus interpersonal psychotherapy for major depressive disorder. Trials were identified by searching the Cochrane Library's CENTRAL, Medline via PubMed, EMBASE, Psychlit, PsycInfo, and Science Citation Index Expan

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Seewald, Nicholas J., Kelley M. Kidwell, Inbal Nahum-Shani, Tianshuang Wu, James R. McKay, and Daniel Almirall. "Sample size considerations for comparing dynamic treatment regimens in a sequential multiple-assignment randomized trial with a continuous longitudinal outcome." Statistical Methods in Medical Research 29, no. 7 (2019): 1891–912. http://dx.doi.org/10.1177/0962280219877520.

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Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen is a sequence of prespecified decision rules which can be used to guide the delivery of a sequence of treatments or interventions that is tailored to the changing needs of the individual. The sequential multiple-assignment randomized trial is a research tool which allows for the construction of effective dynamic treatment regimens. We derive easy-to-use formulae for computing the total sample size for three common two-stage sequential multiple-assignment randomized

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Luís, Ângelo, Fernanda Domingues, and Luísa Pereira. "Association between berries intake and cardiovascular diseases risk factors: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials." Food & Function 9, no. 2 (2018): 740–57. http://dx.doi.org/10.1039/c7fo01551h.

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The main goal of this work was to clarify the effects of the consumption of berries on cardiovascular disease (CVD) risk factors by performing a systematic review followed by a meta-analysis and a trial sequential analysis (TSA).

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Schwendicke, Falk, Gerd Göstemeyer, and Christian Gluud. "Cavity lining after excavating caries lesions: Meta-analysis and trial sequential analysis of randomized clinical trials." Journal of Dentistry 43, no. 11 (2015): 1291–97. http://dx.doi.org/10.1016/j.jdent.2015.07.017.

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Sillassen, Christina Dam Bjerregaard, Caroline Barkholt Kamp, Johanne Juul Petersen, et al. "Adverse effects with semaglutide: a protocol for a systematic review with meta-analysis and trial sequential analysis." BMJ Open 14, no. 6 (2024): e084190. http://dx.doi.org/10.1136/bmjopen-2024-084190.

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IntroductionSemaglutide is increasingly used for the treatment of type 2 diabetes mellitus, overweight and other conditions. It is well known that semaglutide lowers blood glucose levels and leads to significant weight loss. Still, a systematic review has yet to investigate the adverse effects with semaglutide for all patient groups.Methods and analysisWe will conduct a systematic review and search major medical databases (Cochrane Central Register of Controlled Trials, Medline, Embase, Latin American and Caribbean Health Sciences Literature, Science Citation Index Expanded, Conference Proceed

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Volbeda, M., J. Wetterslev, C. Gluud, J. G. Zijlstra, I. C. C. van der Horst, and F. Keus. "Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis." Intensive Care Medicine 41, no. 7 (2015): 1220–34. http://dx.doi.org/10.1007/s00134-015-3899-6.

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Rizos, E., G. Markozannes, A. Tsapas, and E. Ntzani. "Omega-3 Supplementation And Cardiovascular Disease: Meta-Analysis With Trial Sequential Analysis." Atherosclerosis 287 (August 2019): e284. http://dx.doi.org/10.1016/j.atherosclerosis.2019.06.880.

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Zhao, Yating, Ruixia Zhu, Danni Wang, and Xu Liu. "Genetics of diabetic neuropathy: Systematic review, meta‐analysis and trial sequential analysis." Annals of Clinical and Translational Neurology 6, no. 10 (2019): 1996–2013. http://dx.doi.org/10.1002/acn3.50892.

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Fan, JunChen, HuiMin Zhang, Miao Zhang, FanMei Kong, WenRui Wang, and YuLing Wang. "Moxibustion treatment for knee osteoarthritis: cumulative meta-analysis and trial sequential analysis." Nursing Communications 2, no. 3 (2018): 115. http://dx.doi.org/10.53388/tmrin20180720.

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