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Rozprawy doktorskie na temat „Trials”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Kim, Anne(Anne Y. ). "Optimizing clinical trials with Open Trial Chain." Thesis, Massachusetts Institute of Technology, 2018. https://hdl.handle.net/1721.1/121787.

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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2019<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 59-64).<br>The objective of this thesis is to study the challenges of data sharing in healthcare (namely clinical trials), and propose the use of Open Algorithms (OPAL) as a viable solution for research collaboration that allows for access to data without compromising data ownership (data is only used once for the intended purpose, raw data is never leaked, the value gener

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2

Richert, Laura. "Trial design and analysis of endpoints in HIV vaccine trials." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22048/document.

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Des données complexes sont fréquentes dans les essais cliniques récents et nécessitent des méthodes statistiques adaptées. La recherche vaccinale du VIH est un exemple d’un domaine avec des données complexes et une absence de critères de jugement validés dans les essais précoces. Cette thèse d’Université concerne des recherches méthodologiques sur la conception et les aspects statistiques des essais cliniques vaccinaux du VIH, en particulier sur les critères de jugement d’immunogénicité et les schémas d’essai de phase I-II. A l’aide des données cytokiniques multiplex, nous illustrons les aspec

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3

Cuevas, Arriagada Ricardo Enrique, and Bustos Neil William Páez. "B-TRIALS." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/146375.

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TESIS PARA OPTAR AL GRADO DE MAGÍSTER EN ADMINISTRACIÓN<br>Ricardo Enrique Cuevas Arriagada [Parte I], Neil William Páez Bustos [Parte II]<br>El presente trabajo desarrolla una idea de negocio llamada B-Trials, cuyo origen surge a partir de una necesidad específica en la ejecución de Estudios Clínicos de la Industria Farmacéutica local, que corresponde al aumento en la participación de pacientes en la ejecución de los protocolos de estudios, a modo de aumentar la competitividad frente a los otros países de la región. Actualmente, son los médicos tratantes, colegas y/o contactos de los m

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4

Dias, Claire Rhiannon. "Olympic trials." Thesis, Bangor University, 2014. https://research.bangor.ac.uk/portal/en/theses/olympic-trials(feb17a88-72fb-4577-9369-810a7420399e).html.

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Olympic Trials is a literary thriller that explores the dark side of sporting culture, including the many sacrifices, dysfunctional relationships and extreme behaviours that are common aspects of participating in a high performance sport environment. Juxtaposed with the stories of the athletes, there is the tale of an aspiring terrorist. His relentless devotion to a coach-like cult leader, and his physical, spiritual and psychological struggles on his journey to the Olympic Games mirrors the challenges of the athletes. The research portion of the thesis examines many of the texts generally inc

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5

Loudon, Kirstine. "PRECIS-2 : making trials matter : providing an empirical basis for the selection of pragmatic design choices in clinical trials." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/af271d88-4652-41e0-b280-4772cc30f8c4.

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Aim PRECIS (PRagmatic Explanatory Continuum Indicator Summaries 2009) is a tool with a simple wheel format that trialists can use when designing their trials to improve the applicability of results but users highlighted problems. The aim of the study was to produce an improved and validated version of PRECIS, called PRECIS-2 and test this tool out with trial teams designing primary care trials. Methods Brainstorming and a 2-round Delphi survey of authors who cited PRECIS plus user-testing of candidate PRECIS-2 models was followed by validity and reliability testing of the most promising PRECIS

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6

Carvajal, Luis A. Rodriguez. "Multivariate crossover trials." Thesis, University of Warwick, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336783.

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7

Kopec, David M., and Jeffrey J. Gilbert. "Overseeding Fairway Trials." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2001. http://hdl.handle.net/10150/216378.

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Fifty-one overseed entries were evaluated in 1997-1998 for turfgrass performance. New experimental accessions of perennial ryegrass were darker in color than most of the commercially available germplasm included in this test. Ryegrass germplasm had better turfgrass quality after April, than did mixtures of perennial ryegrass with Poa trivialis, which performed well in December, January and March. General appearance for total plot leaf texture was best generally among the Poa trivialis containing mixtures. Hybrid (or intermediate) ryegrasses (L. which are crosses between perennial X annual ryeg

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8

Bartoszuk, Karin. "Randomized Control Trials." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/4161.

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9

Julian, Robert F. "The role of the judge and jury in complex trials." Thesis, Queen Mary, University of London, 2008. http://qmro.qmul.ac.uk/xmlui/handle/123456789/28172.

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This thesis examines the mode of trial concerns in the U.S.A., New York State, California, England and Wales and Canada --specifically the ability of the jury to comprehend complex cases and the perception/reality that bench trials may not be as fair as jury trials. Defining complex cases as those involving serious fraud indictments, capital murder trials, and lawsuits or indictments against corporations and their managers, the thesis examines problems associated with jury trials in such cases. It evaluates the comparative law and customs and practices regarding the use of juries, emphasizing

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10

Caldwell, Patrina Ha Yuen. "The Recruitment of Children to Randomised Controlled Trials." University of Sydney. Paediatrics and Child Health, 2003. http://hdl.handle.net/2123/579.

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Abstract Background The randomised-controlled trial (RCT) provides the best evidence for evaluating treatment effects and is accepted as a gold standard for clinical and regulatory decision making (1;2). One of the major challenges to the conduct of RCTs is the recruitment of adequate numbers of participants. Inadequate numbers reduce the power of a study to detect statistically significant treatment effects, and may cause delays, increased costs and failure to complete trials. The need for clinical trials in children has been increasingly recognised by the scientific community, result

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11

VanMeter, Ashley. "Time to stabilization : number of practice trials and measured trials needed /." Connect to Online Resource-OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1178291778.

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12

VanMeter, Ashley D. "Time to Stabilization: Number of Practice Trials and Measured Trials Needed." University of Toledo / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1178291778.

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13

Whitehead, Amy. "Sample size justifications for pilot trials of publicly funded randomised controlled trials." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/15822/.

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A sample size estimate for a clinical trial is an important issue as incorrectly estimating it could have both ethical and financial implications for the trial. Calculating the required sample size for a trial with a continuous outcome requires an estimate of the population variance. A pilot trial can be used to get an estimate of the population variance. However, pilot trials are often small and may give imprecise estimates; adjustment methods are discussed which allow for this imprecision. Theoretical minimum values for the overall trial sample size when using an adjustment method to design

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14

Menezes, Prema Miller William C. "Is there a trial effect in HIV clinical trials? identifying who participates in clinical trials and assessing the effect of trial participation on the response to highly active antiretroviral therapy /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2061.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology, School of Public Health." Discipline: Epidemiology; Department/School: Public Health.

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15

Coskinas, Xanthi. "Changes to design aspects of ongoing randomised controlled trials." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29452.

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Unplanned changes to the research plan of a randomised controlled trial (RCT) may be a necessary response to unforeseen circumstances. Such changes can help ensure the value and relevance of a trial, but also have the potential to introduce a bias if performed inappropriately. This thesis addresses three broad aims. The first was to highlight the methodological implications of approaches to making various unplanned changes through a series of simulation studies. The second was to estimate the prevalence of such changes to a contemporary sample of published RCTs registered with the Australi

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16

Vickers, Andrew J. "Homoeopathy and clinical trials." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302395.

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17

McMillan, Donald Calum. "Mass participation user trials." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3656/.

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This thesis investigates how researchers can take advantage of the rapid adoption of mobile technology that has brought with it transformations in social and cultural practice; the expectations of what computers are, what they can do, and the role of digital objects in everyday life. In particular this thesis presents and discuses the use of new App Store style software distribution methods to reduce the cost, in terms of researcher time and hardware, of recruiting a large group of participants for a trial ‘in the wild’ while increasing the potential diversity of users is becoming an attractiv

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18

Zhang, Yifan. "Bayesian Adaptive Clinical Trials." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070079.

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Bayesian adaptive designs are emerging as popular approach to develop adaptive clinical trials. In this dissertation, I describe the mathematical steps for computing the theoretical optimal adaptive designs in biomarker-integrated trials and in trials with survival outcomes. Section 1 discusses the optimal design in personalized medicine. The optimal design maximizes the expected trial utility given any pre-specified utility function, though the discussion here focuses on maximizing responses within a given patient horizon. This work provides absolute benchmark for the evaluation of trial des

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19

Connolly, Thomas. "Competition in variety trials." Thesis, Heriot-Watt University, 1992. http://hdl.handle.net/10399/1476.

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20

Oebker, N. F., and Marvin Butler. "Yuma Cauliflower Variety Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1986. http://hdl.handle.net/10150/214144.

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21

Butler, M. D., N. F. Oebker, and J. A. Davis. "1987 Broccoli Variety Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1988. http://hdl.handle.net/10150/214152.

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22

Butler, M. D., N. F. Oebker, and J. A. Davis. "1987 Cauliflower Variety Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1988. http://hdl.handle.net/10150/214153.

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Butler, M. D., and J. A. Davis. "Broccoli Downy Mildew Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1988. http://hdl.handle.net/10150/214161.

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24

McGrady, J., N. Oebker, P. Tilt, J. Nelson, M. Butler, and M. White. "Oriental Vegetable Cultivar Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1988. http://hdl.handle.net/10150/214169.

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25

McGrady, John, and Phil Tilt. "Oriental Vegetable Cultivar Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1989. http://hdl.handle.net/10150/214250.

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26

Butler, Marvin, and Keith Mayberry. "Cantaloupe Variety Trials, 1989." College of Agriculture, University of Arizona (Tucson, AZ), 1990. http://hdl.handle.net/10150/214471.

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27

Wilcox, Mark. "Cantaloupe Variety Trials 1996." College of Agriculture, University of Arizona (Tucson, AZ), 1996. http://hdl.handle.net/10150/214723.

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28

Kopec, David M., Charles F. Mancino, Andrew E. Ralowicz, Michael J. Petty, Mark Olson, and Hisham N. Moharram. "Winter Turf Performance Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1989. http://hdl.handle.net/10150/216075.

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Overseeding trials were conducted to evaluate the turf-type fitness of cool season grasses for use in the desert when bermudagrass is dormant. Perennial ryegrass, fine fescues, rough stalk bluegrasses and creeping bentgrasses were tested for turfgrass quality, color, percent ground cover and uniformity under a close mowing (3/8 inch) regime. Entries varied significantly from each other once seasonal hard frosts did not recur after January. Certain entries had better turf performance under hot (late spring) conditions. Both commercially available and experimental germplasm were evaluated.

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29

Kopec, David M., Jeffrey J. Gilbert, and David M. Jensen. "Ryegrass Germplasm Overseeding Trials." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2001. http://hdl.handle.net/10150/216377.

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A field test was conducted to evaluate the turf performance of improved hybrid ryegrass (sometimes called intermediate ryegrass) Lolium hybridum versus that of perennial ryegrass germplasm (Lolium perenne) for winter overseeding purposes. "Gulf" annual ryegrass was also evaluated for comparison purposes. On all evaluation dates, the treatment effect was significant for all visual response variables measured (quality, color, texture, density, etc.). The mixture of LHRT hybrid ryegrass/Poa trivialis established quicker than other treatments during the first month (November). Perennial ryegrass e

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30

Heathman, Stanley. "1985 Nutsedge Control Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1986. http://hdl.handle.net/10150/219698.

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31

Scarale, M. G. "RESPONSE - ADAPTIVE CLINICAL TRIALS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/344736.

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The question we posed at the beginning of this thesis was whether, in the presence of a clinical superiority of one of two possible treatments, it was possible to find an appropriate statistical methodology that would allow us to reach this goal. We were thus led to explore many possibilities to carry out this analysis and randomly assign patients to the two treatments, as required by the particular nature of these experiments. Specifically, we made a close examination of the methods of randomization, especially appreciating the flexibility of the adaptive responses, and could see the strength

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32

Lui, Wai-fan. "Clinical trials research methodology current practice in Hong Kong and training programme development /." Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/HKUTO/record/B38628582.

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Ali, Myzoon. "The Virtual International Stroke Trials Archive (VISTA) : promulgation of a clinical trial resource." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/509/.

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Abstract Chapter 1 provides an introduction to stroke including its current prevalence both nationally and globally, aetiology, global importance and social & financial burden. We also describe here current acute stroke management practices, the role of clinical trials in the development of therapies, the richness of data within clinical trials and changes in regulatory thinking regarding data access. We provide recommendations for the use of trial data for novel exploratory investigations of clinical trial design and epidemiological studies. In Chapter 2 we describe the establishment of the V

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34

Čekanauskaitė, Asta. "Informedness about clinical trials of patients participating in placebo-controlled clinical trials in Lithuania." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20130114_081952-77101.

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The dissertation aims to analyse the problem of informed consent in clinical drug trials. Understanding of the provided information is one of the basic components of a person’s sound and informed decision to participate in a clinical trial. Our research evaluated informedness about clinical trials of patients participating in clinical drug trials in Lithuania, with emphasis on the informedness about key elements of clinical trial design (placebo-control, double-blindness, and randomisation). An anonymous survey of patients participating in clinical drug trials was conducted for the purposes of

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35

Hutchison, Catherine B. "A randomised controlled trial of an audiovisual patient information intervention in cancer clinical trials." Thesis, University of Stirling, 2008. http://hdl.handle.net/1893/442.

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Introduction and background Recruitment to cancer clinical trials needs to be improved, as does patient understanding about clinical trials, to enable patients to make an informed choice about whether or not to take part. The main reason that clinically eligible patients do not take part in clinical trials is because they refuse; poor understanding of the research has been associated with patient refusal. Audiovisual patient information (AVPI) has been shown to improve knowledge/understanding in various areas of practice but there is limited information about its effect in the cancer clinical

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36

Bloxham, Donald. "Genocide on trial : war crimes trials and the formation of Holocaust history and memory /." Oxford : Oxford university press, 2003. http://catalogue.bnf.fr/ark:/12148/cb390951061.

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Texte remanié de: Ph.D.--Southampton, 1998. Titre de soutenance : The Holocaust on trial : the war crime trials in the formartion of history and memory.<br>Documents en annexes (verdicts du procès de Nuremberg et d'autres procès). Bibliogr. p. 233-261. Index.

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37

Kehl, Victoria. "Responder Identification in Clinical Trials." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-5908.

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Harshbarger, William R. "The trials of Len Small /." View online, 1989. http://ia301543.us.archive.org/1/items/trialsoflensmall00hars/trialsoflensmall00hars.pdf.

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39

Carson, Connor. "Vaccine trials against canine leishmaniasis." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/3637/.

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Zoonotic visceral leishmaniasis (ZVL) is a fatal disease caused by the sandfly-borne intracellular protozoan parasite Leishmania infantum, and vaccine development in the reservoir host (the domestic dog) is a current research priority. The aims of this study were (1) to conduct safety and immunogenicity trials of two candidate vaccines in dogs, and (2) to compare and demonstrate the utility of immunological and molecular tools for measurement of vaccine efficacy in naturally exposed dogs. DNA/ modified vaccinia virus Ankara (MVA) prime/boost canine vaccines expressing the Leishmania proteins T

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40

Ulucanlar, Selda. "Randomised controlled trials and equipoise." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535188.

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41

Sydow, Victoria. "Clinical Trials - Competitive resource management." Thesis, KTH, Skolan för bioteknologi (BIO), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-149476.

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42

Murphy, Jeremy James. "Clinical trials in cerebrovascular disease." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293328.

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43

Machin, David. "Statistical aspects of clinical trials." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257667.

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44

Lewis, Nigel da Costa. "Surrogate markers in clinical trials." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620204.

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45

Ainsley, Anne Elizabeth. "Interplot correlations in variety trials." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/13828.

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46

Rahman, Najib. "Clinical trials in pleural disease." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:930991f1-3424-4b96-984e-06df7f6e9204.

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The focus of this thesis is on practice changing clinical studies which impact upon the day to day treatment of patients with pleural infection, answering specific questions on several aspects of patient management. Specific areas of assessment in this thesis include: Assessment of the current evidence for optimal drain size choice in patients with pleural infection; Analysis and statistical modelling of a previous cohort of patients with pleural infection, in order to assess optimal drain size choice in pleural infection; The design, conduct and analysis of a 2 x 2 factorial multi-centre rand

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47

Colucci, Elisabetta. "Dose in stroke rehabilitation trials." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/62989/.

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Background: the dose and the length of rehabilitative interventions for optimal motor recovery after stroke are unknown. Dose optimization studies are required as precursors to efficacy trials, but are rarely conducted in stroke rehabilitation research. Objective: to overcome the knowledge gap on appropriate dose and length of rehabilitative interventions guiding the implementation of novel effective approaches to dose optimization in stroke rehabilitation research. Method: two systematic reviews on dose optimization in exercise-based training and pharmaceutical clinical research guided the de

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48

McGee, Richard Gerard Eamonn. "Trials and Outcomes in Surgery." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12827.

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Surgery, as a scientific discipline, should be supported by research. Surgeons depend on the availability and quality of an adequate evidence base to provide best possible care. Randomised trials are often considered the best form of evidence when assessing the efficacy of an intervention. Surgical research has been derided because of the paucity of randomised trials published. Many efforts have been made to combat this crisis of credibility, including the creation of the IDEAL Collaboration, which aims to improve “the quality of research in surgery by emphasizing appropriate methods, transpar

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49

Munda, Bruce, Tim C. Knowles, Art Meen, Vic Wakimoto, and Bill Worthy. "Winter Forage Cover Crop Trials." College of Agriculture, University of Arizona (Tucson, AZ), 1998. http://hdl.handle.net/10150/208283.

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Several crops were evaluated at Worthy farms, near Marana, AZ, Wakimoto farms, Mohave Valley, near Bullhead City, AZ, and the Tucson Plant Materials Center for use as a winter cover crop following cotton with potential to reduce wind erosion and produce one to two hay cuttings. Hairy vetch (Vicia villosa), 'Lana' woolypod vetch (Vicia villosa ssp. varia), 'Papago' pea (Pisum sativum), and 'Biomaster' pea (Pisum sativum) were sown at the Tucson Plant Materials Center. Species sown at Worthy farm were: Papago pea, Lana vetch, and Biomaster pea. Species sown at Wakimoto farm were: Biomaster pea,

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50

Butler, Marvin. "Yuma County Boligrow Trials, 1985." College of Agriculture, University of Arizona (Tucson, AZ), 1986. http://hdl.handle.net/10150/214111.

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