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Basu, Shrivastava Meenakshi. "Régulation de la stabilité de NFATc3 par SUMO et les E3 ubiquitine-ligases Trim39 et Trim17". Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT043.
Pełny tekst źródłaNFAT (Nuclear factor of activated T cells) transcription factors play important physiological roles in the development and function of many organs, notably in the immune system and nervous system. As a consequence, their dysregulation has been implicated in various human diseases such as cancer, neurodegenerative diseases, and auto-immune diseases. The regulation of NFAT activity by calcium-dependent nuclear-cytoplasmic shuttling has been extensively studied. In contrast, the regulation of NFAT protein level by the ubiquitin-proteasome system is still poorly understood. However, NFATs are short-lived proteins and regulation of their stability is critical for controlling their activity.In a previous study, my group has shown that the E3 ubiquitin-ligase Trim17 binds NFATc3 but does not promote its ubiquitination and rather stabilizes it. Preliminary results suggested that Trim39, a partner of Trim17, might be an E3 ubiquitin-ligase for NFATc3 and that SUMOylation of NFATc3 might modulate its stability. Therefore, the goal of my PhD was to understand the mechanisms through which Trim39, Trim17, and SUMO regulate the stability of NFATc3.During my PhD, I have characterized Trim39 as an E3 ubiquitin-ligase of NFATc3. Indeed, my results indicate that overexpression of Trim39, but not its inactive mutant, induces the ubiquitination of NFATc3 in cells. In contrast, silencing of endogenous Trim39 decreases the ubiquitination level of NFATc3. Recombinant Trim39 directly induces the ubiquitination of NFATc3 in vitro. Moreover, overexpression of Trim39 decreases the protein levels of NFATc3 whereas the silencing of Trim39 increases it. I have also shown that Trim17, which can bind Trim39, inhibits Trim39-mediated ubiquitination of NFATc3, both in cells and in vitro. Trim17 acts by both reducing the intrinsic E3 ubiquitin-ligase activity of Trim39 and by preventing the interaction between NFATc3 and Trim39. Furthermore, I found that a SUMOylation-deficient mutant of NFATc3 is less ubiquitinated and more stable than the wild type NFATc3, suggesting that SUMOylation of NFATc3 is important for its ubiquitination and degradation. Importantly, I identified one SUMO interacting motif (SIM) in the sequence of Trim39 through which Trim39 binds SUMO2 polymers via one of these SIMs. Mutation of this SIM in Trim39 or SUMOylation consensus sites in NFATc3 decreased the interaction between Trim39 and NFATc3, and the ubiquitination of NFATc3 mediated by Trim39. These results strongly suggest that Trim39 binds and ubiquitinates preferentially the SUMOylated forms of NFATc3 and therefore acts as a SUMO-targeted E3 ubiquitin-ligase (STUbL) for NFATc3. Finally, we have measured the impact of these mechanisms on the physiological function of NFATc3. I first found that Trim39 decreases the transcriptional activity of NFATc3. Furthermore, using primary cultures of cerebellar granule neurons as a model, we have shown that the mutation of the SUMOylation sites of NFATc3 and silencing of endogenous Trim39 enhances neuronal apoptosis, probably by stabilizing the NFATc3 protein. Taken together, these data indicate that Trim39 modulates neuronal apoptosis by acting as a STUbL for NFATc3 and by controlling its stability
Buberl, Cilli Dana [Verfasser]. "Expressionsanalyse der putativen E3 Ligasen Trim23 und Trim7 in der frühen Neuralentwicklung von Xenopus laevis / Cilli Dana Buberl". Halle, 2017. http://d-nb.info/1137867698/34.
Pełny tekst źródłaBorle, Pawar Ankush [Verfasser], Norbert [Akademischer Betreuer] Frey i Dennis [Gutachter] Schade. "Functional characterization of TRIM24 and TRIM32 proteins in the heart through their interaction with Dysbindin / Ankush Borle Pawar ; Gutachter: Dennis Schade ; Betreuer: Norbert Frey". Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1220691259/34.
Pełny tekst źródłaLocke, Matthew. "TRIM32 in Genetic Disease". Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514962.
Pełny tekst źródłaVENUTO, SANTINA. "Dissecting the TRIM8 role in the pathogenesis of glioma". Doctoral thesis, Università degli Studi di Foggia, 2019. http://hdl.handle.net/11369/382357.
Pełny tekst źródłaHuman gliomas are a heterogeneous group of primary malignant brain tumors, whose molecular pathogenesis is not yet solved. Therefore, understanding the molecular mechanisms underlying their aggressive behavior may lead to better management, appropriate therapies, and good outcomes through the identification of novel specific glioma-associated genes. Members of the tripartite motif (TRIM) proteins family are involved in many biological processes, including transcriptional regulation, cell proliferation and differentiation and cell cycle progression. Alterations of TRIM proteins are associated with a variety of pathologies like developmental disorders, inflammatory diseases and cancers. Among TRIMs protein family, TRIM8 encodes an E3 ubiquitin ligase involved in various pathological processes, including hypertrophy, antiviral defense, encephalopathy, and cancer development. We have identified TRIM8 as a gene aberrantly expressed in gliomas, whose expression correlates with unfavorable clinical outcome in glioma patients. To gain insights into the TRIM8 functions, we profiled the TRIM8 transcriptome and interactome in primary mouse embryonic neural stem cells using RNA-sequencing and proteomics, followed by bioinformatics analysis. Functional analysis, including biochemical and cellular assays were then performed to explore TRIM8 roles in different pathways. Our study firstly identified enriched pathways related to the neurotransmission and to the central nervous system (CNS) functions, providing additional evidence about the existence of a functional interactive crosstalk between TRIM8 and STAT3 with possible implications in the development and progression of glioma. Then, we found that TRIM8 interacts with KIFC1 and KIF11/Eg5, two master regulators of mitotic spindle assembly and cytoskeleton reorganization. Exploring the TRIM8 role in the mitotic spindle machinery, we showed that TRIM8 localizes at the mitotic spindle during mitosis and plays a role in centrosome separation at the beginning of mitosis with a subsequent delay of the mitotic progression and impact on chromosomal stability. Our results substantiate the role of TRIM8 in the brain functions through the deregulation of genes involved in different CNS-related pathways, including JAK-STAT. Moreover, we provided insights on the physiological function of TRIM8 in the mitotic spindle machinery, pointing to an emerging role for TRIM8 in the regulation of mitosis
Crichton, Jennifer E. "The Role of the E3-ubiquitin Ligase Trim17 in the Mitochondrial Cell Death Pathway". Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23715.
Pełny tekst źródłaSimpson, Shmona. "Genetic, structural, and functional exploration of the restrictive capacity of TRIM proteins against immunodeficiency viruses". Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:1af588ba-603a-4f39-9443-bb1a95d983f5.
Pełny tekst źródłaGuimarães, Dimitrius Santiago Passos Simões Fróes. "Caracterização bioquímica e celular da proteína TRIM49". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-10042018-112409/.
Pełny tekst źródłaAutophagy is the process of degradation of intracellular proteins through their directioning to the lysosome. TRIM proteins can directely recognize autophagic cargo and also act as a hub for the phagophore nucleation complex, however the function of each domain and the role of the E3 ligase activity in this process is unknown. The TRIM49 protein cloned and expressed in E. coli or in human cells HEK23T showed no ubiquitin E3 ligase activity in vitro and cells transfected with the wild type protein showed lower levels of polyubiquitinated proteins, indicating that TRIM49 is not a bona fide E3 ubiquitin ligase. Cells challenged with Htt74Q presented lower cytotoxicity levels when cotransfected with wild type TRIM49, when compared with the RING domain mutant or with the truncated protein lacking the SPRY domain, indicating that both domains are required for its cellular activity. The wild type protein colocalizes with the autophagic marker LC3 after treatment with the autophagy inhibitor bafilomycin A1. Taken together, these results indicate that the TRIM49 protein plays a role in protein degradation independently of a E3 ligase activity.
Bartsch, Frederike [Verfasser], i Elke [Akademischer Betreuer] Cario. "Funktion und Regulation von TRIM58 in der myeloischen Immunabwehr / Frederike Bartsch ; Betreuer: Elke Cario". Duisburg, 2019. http://d-nb.info/1196008418/34.
Pełny tekst źródłaMcGuire, Cy Christopher. "Evaluation of PGR properties of TRIMAX in cotton". Texas A&M University, 2005. http://hdl.handle.net/1969.1/2605.
Pełny tekst źródłaRoberts, Simon Benedict. "Investigating new genetic susceptibility loci in osteoarthritis". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28982.
Pełny tekst źródłaReusse, Ekaterina [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis i Heiko [Gutachter] Hessenkemper. "Innovative industrielle Erdgasbeheizungssysteme auf der Basis der Porenbrennertechnologie für Hochtemperaturanwendungen / Ekaterina Reusse ; Gutachter: Dimosthenis Trimis, Heiko Hessenkemper ; Betreuer: Dimosthenis Trimis". Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2013. http://d-nb.info/1220911461/34.
Pełny tekst źródłaFrenzel, Isabel [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis i Sven [Gutachter] Kureti. "Flammenstruktur und Rußbildung in Verbrennungsprozessen mit ethanol- und butanolhaltigen Kraftstoffen / Isabel Frenzel ; Gutachter: Dimosthenis Trimis, Sven Kureti ; Betreuer: Dimosthenis Trimis". Freiberg : Technische Universität Bergakademie Freiberg, 2018. http://d-nb.info/1226101038/34.
Pełny tekst źródłaSchaller, T. "Characterisation of TRIM5α and related retroviral restriction factors". Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18779/.
Pełny tekst źródłaReddi, Tejaswini Satya. "TRIM22 IS A NOVEL RESTRICTION FACTOR OF HERPESVIRUSES". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17464655.
Pełny tekst źródłaMedical Sciences
Jerabkova, Katerina. "Les rôles de Trim15 et UCHL3 dans la régulation, médiée par l’ubiquitine, du cycle cellulaire". Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ034.
Pełny tekst źródłaMitosis is tightly controlled by ubiquitin signaling and is crucial to maintain genome integrity. In this work, I investigated the function of the deubiquitinating enzyme UCHL3 and the E3 ubiquitin ligase TRIM15. I observed that TRIM15 regulates cell adhesion and motility. UCHL3 was identified in a high-content screen, as a critical factor controlling the chromosome alignment and segregation. Interestingly, it has been previously reported that UCHL3 levels are altered in various cancer types. Using a proteomic approach, we identified Aurora B kinase as a potential mediator of these phenotypes. Since aneuploidy is a hallmark of many cancers, and cell adhesion plays an important role in tumor invasion and metastasis, my results suggest that both proteins could play a role in carcinogenesis
Anger, Stephan [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis i Angelika [Gutachter] Heinzel. "Untersuchungen zur Prozessgasaufbereitung von Flüssiggas für die Dampfreformierung in Brennstoffzellen-BHKW / Stephan Anger ; Gutachter: Dimosthenis Trimis, Angelika Heinzel ; Betreuer: Dimosthenis Trimis". Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2016. http://d-nb.info/122091231X/34.
Pełny tekst źródłaRau, Florian [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis i Andreas Siegfried [Gutachter] Bräuer. "Einsatz biogener Kraftstoffe zur Senkung der Emissionen von stationären Verbrennungsmotoren / Florian Rau ; Gutachter: Dimosthenis Trimis, Andreas Siegfried Bräuer ; Betreuer: Dimosthenis Trimis". Freiberg : Technische Universität Bergakademie Freiberg, 2021. http://d-nb.info/1240475837/34.
Pełny tekst źródłaKim, Kyusik. "HIV-1 Evasion of Human TRIM5α via Cyclophilin A". eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1089.
Pełny tekst źródłaBouchard, Amélie. "Évolution moléculaire in vitro du facteur de restriction TRIM5α". Thèse, Université du Québec à Trois-Rivières, 2009. http://depot-e.uqtr.ca/1462/1/030123866.pdf.
Pełny tekst źródłaHao, Chengcheng. "Improved Sampling-based Alpha Matting in Images and Video". Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23417.
Pełny tekst źródłaYeo, Richard Fraser. "The three dimensional simulation of VLF signal scattering". Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286749.
Pełny tekst źródłaWalter, Christopher John. "Stereoselective acceleration of Diels-Alder reactions by synthetic enzymes". Thesis, University of Cambridge, 1994. https://www.repository.cam.ac.uk/handle/1810/272679.
Pełny tekst źródłaSchulz, Bastian [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis i Jens-Uwe [Gutachter] Repke. "Entwicklung eines Reformierungssystems zur Bereitstellung von Synthesegas für den maritimen Betrieb einer MCFC-Brennstoffzelle / Bastian Schulz ; Gutachter: Dimosthenis Trimis, Jens-Uwe Repke ; Betreuer: Dimosthenis Trimis". Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2013. http://d-nb.info/1220837377/34.
Pełny tekst źródłaSchank, Troy C. "Optimal aeroelastic trim for rotorcraft with constrained, non-unique trim solutions". Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22654.
Pełny tekst źródłaCommittee Chair: Dimitri N. Mavris; Committee Co-Chair: Daniel P Schrage; Committee Member: David A. Peters; Committee Member: Dewey H. Hodges; Committee Member: J.V.R. Prasad.
Blaia, Junior Antonio Carlos Teixeira [UNESP]. "Geração automática de Trimap para Matting Digital de Imagens e Vídeo". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/89346.
Pełny tekst źródłaTécnicas de composição de imagens, com extração de objetos em primeiro plano para serem combinados com um novo plano de fundo, são muito utilizadas em aplicações que vão desde simples montagens em fotos até produções cinematográficas. Estas técnicas são chamadas demattingdigital. Com elas é possível minimizar custos das produções, uma vez que o ator não precisa estar realmente no local onde a cena irá acontecer. Esta característica também viabiliza sua utilização em programas realizados para a televisão digital, que demandam uma alta qualidade da imagem. Diversas abordagens demattingdigital utilizam marcações feitas nas imagens (como informações extras), para determinar o que é o primeiro plano, o plano de fundo e as áreas de incerteza. O conjunto destas informações extras é chamado detrimap, definida por um mapa triplo representando a segmentação da imagem de entrada. Otrimap é feito, geralmente, a partir de marcações manuais realizadas pelo usuário. Levando em consideração este contexto, o presente trabalho objetivou o desenvolvimento de dois métodos para a geração detrimaps de maneira automática (sem interação do usuário), baseando-se, para isto, em informações de profundidade e/ou cores dospixels das imagens de entrada. Os métodos desenvolvidos foram implementados e comparados com suas versões manuais, tendo apresentado resultados quantitativamente semelhantes, para imagens. Os métodos revelaram, também, potencial para serem aplicados em vídeos
Techniques of composing images with extracting objects in the foreground to be combined with a new background, are widely used in applications ranging from simple assemblies on photos to filmmaking. these techniques are called digital matting. With them you can minimize costs of production, since the actor does not need to be really where the scene will happen. this feature also enables its use in programs made for television digital, which demand a high quality image. Several approaches utilize digital matting marks made on images (such as extra informa-tion), to determine what is the foreground, the background and areas of uncertainty. All these extra information is called a trimap, defined for a triple map representing the seg-mentation of the input image. The trimap is made, generally, from markings made by the user manuals. Considering this context, this study aimed to develop Two methods for generating trimaps either automatically (without interaction user), relying, for this, in depth information and / or colors of the pixels the input images. The developed methods were implemented and compared with their manual versions and tested quantitatively similar for images. The methods also revealed the potential to be applied in videos
Port, Yasmine [Verfasser]. "The Role of TRIM71 in Male Germ Cell Development / Yasmine Port". Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1240761260/34.
Pełny tekst źródłaBlaia, Junior Antonio Carlos Teixeira. "Geração automática de Trimap para Matting Digital de Imagens e Vídeo /". São José do Rio Preto, 2013. http://hdl.handle.net/11449/89346.
Pełny tekst źródłaBanca: João Fernando Marar
Banca: Ildeberto Aparecido Rodello
Resumo: Técnicas de composição de imagens, com extração de objetos em primeiro plano para serem combinados com um novo plano de fundo, são muito utilizadas em aplicações que vão desde simples montagens em fotos até produções cinematográficas. Estas técnicas são chamadas demattingdigital. Com elas é possível minimizar custos das produções, uma vez que o ator não precisa estar realmente no local onde a cena irá acontecer. Esta característica também viabiliza sua utilização em programas realizados para a televisão digital, que demandam uma alta qualidade da imagem. Diversas abordagens demattingdigital utilizam marcações feitas nas imagens (como informações extras), para determinar o que é o primeiro plano, o plano de fundo e as áreas de incerteza. O conjunto destas informações extras é chamado detrimap, definida por um mapa triplo representando a segmentação da imagem de entrada. Otrimap é feito, geralmente, a partir de marcações manuais realizadas pelo usuário. Levando em consideração este contexto, o presente trabalho objetivou o desenvolvimento de dois métodos para a geração detrimaps de maneira automática (sem interação do usuário), baseando-se, para isto, em informações de profundidade e/ou cores dospixels das imagens de entrada. Os métodos desenvolvidos foram implementados e comparados com suas versões manuais, tendo apresentado resultados quantitativamente semelhantes, para imagens. Os métodos revelaram, também, potencial para serem aplicados em vídeos
Abstract: Techniques of composing images with extracting objects in the foreground to be combined with a new background, are widely used in applications ranging from simple assemblies on photos to filmmaking. these techniques are called digital matting. With them you can minimize costs of production, since the actor does not need to be really where the scene will happen. this feature also enables its use in programs made for television digital, which demand a high quality image. Several approaches utilize digital matting marks made on images (such as extra informa-tion), to determine what is the foreground, the background and areas of uncertainty. All these extra information is called a trimap, defined for a triple map representing the seg-mentation of the input image. The trimap is made, generally, from markings made by the user manuals. Considering this context, this study aimed to develop Two methods for generating trimaps either automatically (without interaction user), relying, for this, in depth information and / or colors of the pixels the input images. The developed methods were implemented and compared with their manual versions and tested quantitatively similar for images. The methods also revealed the potential to be applied in videos
Mestre
Zhang, Xuzhe. "Eutherian-specific gene TRIML2 attenuates inflammation in the evolution of placentation". University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573576401238203.
Pełny tekst źródłaWatkinson, Ruth Elizabeth. "Intracellular antibody receptor TRIM21 in viral neutralisation and innate immune signalling". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708305.
Pełny tekst źródłaConwell, Sara. "TRIM27 in HSV-1 Infection: A Story of Loss and Death". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17463971.
Pełny tekst źródłaMedical Sciences
Veillette, Maxime. "TRIM5α : spécificité d'action, résistance virale et implications pour la thérapie génique". Thèse, Université du Québec à Trois-Rivières, 2013. http://depot-e.uqtr.ca/6956/1/030596123.pdf.
Pełny tekst źródłaTag, Andrew George. "Characterization of the Tri10 gene from Fusarium sporotrichioides". [College Station, Tex. : Texas A&M University, 2003. http://hdl.handle.net/1969.1/64.
Pełny tekst źródła"Major Subject: Plant Pathology" Title from author supplied metadata (record created on Jul. 18, 2005.) Vita. Abstract. Includes bibliographical references.
Demasi, João Otavio Benevides. "Os investimentos internacionais e a reforma das TRIMs". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/2/2135/tde-03122012-160404/.
Pełny tekst źródłaDue to the US economic downturn, the Capital Flows in 2009 were only from the economic order of U.S.$ 1.8 trillion, 82% less than 2007 (US$ 10.5 trillion). In 2009 the daily trading volume of assets were U.S.$ 1.5 trillion with US$ 178 trillion as financial assets. The productive International Investments are one of the bases from the internationalization enterprises and of the capital. By establishing an industrial plant and/or acquire assets of companies, this cross-border flow of capital brings goods, technology, new management practices, inter alios acts. Distinguishing itself, by this way, from the stock market investment of purely speculative character and stateless, from the hot money. Written in 3 (three) chapters, this work search, in the international field, the legal rules from productive flows and the Trade Related Investment Measures (TRIMs) of the World Trade Organization (WTO). These clauses contains Restrictive Business Practices (RBP) that prevents States-Members from the WTO to carry out public policies of national development. Not forgetting the dialogue of sources from international rules, once the WTO is not in clinical isolation from the international law there is a clear clash between the Permanent Sovereignty on Natural Resources and the Right to Development. Between more than 140 (one hundred and forty) cases tried by ICSID, exceptionally and only one (one) the host-State won. Made the examination of the 2 (two) major legal systems of investments. The Triad (USA, EU and Japan) plus South Korea wants a model with more liberal investment rules in the WTO. Discusses this work on the more than 2500 (two thousand and five hundred) Bilateral Investments Treaties (BITs) and Regional Trade Agreements (RTAs) such as NAFTA, the MAI draft, and the Bretton Woods institutions related to FDI and the interaction with doctrine, jurisprudence and trends. UNCTAD strongly criticizes this liberal set of rules, not only the BITs, but also the TRIMs. The core matter from this work is the Indo-Brazilian Joint Statement on the Reform of the TRIMs (G/TRIMS/W/25), that proposes through local purchases and performance requirements the right of management of public policies for national development currently forbidden. This work concludes that the Reform of the TRIMs is a diplomatic impractibility, in a mode that the Right to development can be achieved as an improbable exception
Gil, Mir Maria Eugenia. "Expanding the MDM2 interactome". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25781.
Pełny tekst źródłaEder, Robert [Verfasser], Dimosthenis [Akademischer Betreuer] Trimis, Dimosthenis [Gutachter] Trimis i Eckehard [Gutachter] Specht. "Ein Beitrag zur Entwicklung neuartiger keramischer Wärmeübertrager für Rekuperatorbrenner : Ein Beitrag zur Entwicklung neuartiger keramischer Wärmeübertrager für Rekuperatorbrenner / Robert Eder ; Gutachter: Dimosthenis Trimis, Eckehard Specht ; Betreuer: Dimosthenis Trimis". Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2015. http://d-nb.info/1220911976/34.
Pełny tekst źródłaSchneider, Karin [Verfasser]. "Untersuchung der molekularen Funktion des Stammzellfaktors Trim71 in der Karzinogenese / Karin Schneider". Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1109879881/34.
Pełny tekst źródłaHennig, Janosch. "Structure-function studies on TRIM21/Ro52, a protein involved in autoimmune diseases /". Linköping : Department of of Physics, Chemistry and Biology, Linköping University, 2009. http://www.bibl.liu.se/liupubl/disp/disp2009/tek1272s.pdf.
Pełny tekst źródłaBérubé, Julie. "Influence de l'environnement cellulaire sur l'activité des protéines antirétrovirales TRIM5α et TRIMCyp". Thèse, Université du Québec à Trois-Rivières, 2011. http://depot-e.uqtr.ca/2264/1/030276729.pdf.
Pełny tekst źródłaMielnicka, Monika. "Study of the biological function of TRIM66 protein in spermatogenesis and reproduction". Thesis, Strasbourg, 2022. http://www.theses.fr/2022STRAJ077.
Pełny tekst źródłaTRIM66 is a member of the TIF1 protein family composed of TRIM24, TRIM28 and TRIM33, that have a C-terminus tandem domain PHD-bromodomain. TRIM66 is the least studied member of this family and shows high specificity towards expression in the male germline, specifically in the haploid testis cell population called spermatids. The process of sperm maturation in haploid cells is called spermiogenesis and during this process a major chromatin remodeling takes place with replacement of canonical histones to protamines which happens also during the peak of the expression of TRIM66 in the testis. The impact of TRIM66 on the sperm maturation during spermiogenesis in the testis is unknown. In this work, I characterized the possible function of the TRIM66 by using two mouse models. I found that TRIM66 despite being expressed in spermatids does not impact the sperm fertilization capabilities, however it affects the weight of progeny. The analysis of transcriptome revealed that the upregulated genes in the isolated spermatids population belong to the genes predominantly involved in histone 3 lysine 4 methylation pathway. Furthermore, in vitro binding assays show that the PHD-bromodomain binds to histone H3 only when lysine 4 is unmethylated. All together, my results revealed a paternal effect for Trim66 loss-of-function that is likely caused by TRIM66’s role in H3K4me3 regulation in spermatids
Balastik, Martin. "Trim2 mutant mice as a model for cerebellar ataxia". Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=975117025.
Pełny tekst źródłaBoutanquoi, Pierre-Marie. "Traitement de la fibrose pulmonaire idiopathique : Rôle de TRIM33 et de l’inhibition d’HSPB5". Electronic Thesis or Diss., Bourgogne Franche-Comté, 2019. http://www.theses.fr/2019UBFCI016.
Pełny tekst źródłaIdiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation and extracellular-matrix (ECM) accumulation in the lungs. Transforming-growth-factor (TGF)-β1 is a key profibrotic growth factor involving Smads signaling pathway. We have already shown that the heat shock protein HSPB5 has a positive role on Smads pathway activation in lung fibrogenic processes. TRIpartite Motif-containing 33 (TRIM33) has previously been reported to exert a negative control on TGF-β/Smads signaling but its role in pulmonary fibrogenesis remains unknown.We aimed to study the role of TRIM33 in IPF using ex vivo and in vivo models and to characterize the therapeutic potential of specific HSPB5 inhibitors.TRIM33 was overexpressed in alveolar macrophages and fibroblasts in IPF patients. Its inhibition led to increased TGF-β1 downstream gene expression. In addition TRIM33 depletion worsened TGF-β1 secretion by the macrophages. Moreover, we demonstrated that several specific HSPB5 inhibitors were able to downregulate the up- regulation of mesenchymal differenciation induced by TGF-β1 in in vitro models. Moreover, one of these inhibitors proved to be effective in BLM-induced fibrosis models.In conclusion, this work has allowed to demonstrate the importance of TRIM33 in the development of IPF as well as to characterize efficient HSPB5 specific inhibitors that may be used one day as treatment for IPF
Larrieu, Dorian. "Régulation et fonctions de l'E3 ubiquitine ligase TRIP12 au cours du cycle cellulaire". Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30144.
Pełny tekst źródłaTRIP12 is an E3 ubiquitin ligase that belongs to the HECT (Homologous to the E6-AP Carboxyl Terminus) family. Several proteins are targeted by TRIP12 polyubiquitination which triggers their proteasomal degradation. Among its targets, several proteins are involved in DNA damage responses, chromatin remodelling and p53 pathway activation. Unpublished results of my team showed an increased expression of TRIP12 in pancreatic cancer and pre-neoplastic lesions. My group revealed that TRIP12 polyubiquitinates and provokes the degradation of the transcription factor PTF1a (Pancreas Transcription Factor 1a) stability. Describing for the first time a post-translational regulation of PTF1a. PTF1a is essential in pancreatic development and homeostasis. It inhibits the proliferation of pancreatic cells and is considered as a tumour suppressor gene and. Even if several TRIP12 targets are involved in cellular processes that are tightly cell cycle regulated, the regulation of TRIP12 expression and its functions during the cell cycle was unknown at the beginning of my thesis. I showed that TRIP12 expression and nuclear localization are regulated throughout the cell cycle. I identified an intrinsically disordered domain within the N-terminal region of TRIP12 that permits its interaction to euchromatin. I demonstrated TRIP12 implication in mitosis entry by controlling DNA replication timing Independently of its catalytic activity. TRIP12 is also required for maintaining a correct mitotic progression and chromosomes stability. My results propose TRIP12 as a new chromatin-associated protein that is essential for cell cycle progression and to preserve genome integrity. In the end, my studies will be fundamental to explain the increased expression of TRIP12 protein observed in pancreatic cancer and its impact in carcinogenesis
Haubrich, Kevin [Verfasser], i Carsten [Akademischer Betreuer] Sachse. "RNA binding regulates TRIM25-mediated RIG-I ubiquitination / Kevin Haubrich ; Betreuer: Carsten Sachse". Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1235674649/34.
Pełny tekst źródłaFalcón, Beas Felipe Ernesto. "¿Pueden las células dendríticas maduradas con trimel activar células INKT contra melanoma humano?" Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/168208.
Pełny tekst źródłaMelanoma es la neoplasia cutánea más agresiva, con una incidencia ascendente a pesar de numerosos esfuerzos de prevención. En la actualidad existen diversas estrategias de tratamiento, sin embargo, no todos los pacientes responden a ellas. En nuestro laboratorio se ha ensayado una inmunoterapia basada en células dendríticas (DCs) maduradas con un lisado de líneas celulares de melanoma (TRIMEL), que ha incrementado hasta 3 veces la sobrevida en pacientes que desarrollan una respuesta inmunológica de hipersensibilidad retardada (DTH+). Hasta la fecha no se han desarrollado avances en el estudio de la fracción no peptídica de este lisado ni de su capacidad de activar células iNKT, capaces de reconocer antígenos glicolipídicas en contexto CD1d. Hipótesis: Células iNKT infiltran tumores de pacientes con melanoma avanzado y son capaces de ser activadas in vitro por células dendríticas utilizadas en inmunoterapia antitumoral. Objetivo General: Determinar el rol en pacientes con melanoma de células iNKT infiltrantes de tumor y activadas por células dendríticas maduradas ex vivo utilizadas en inmunoterapia antimelanoma. Métodos: Se determinaron células iNKT infiltrantes de tumor mediante inmunofluorescencia y se correlacionó su presencia en lesiones de melanoma primario en todos los estadios según Breslow con la sobrevida de la enfermedad. Se evaluó la capacidad de las fracciones glicolipídica y proteica de TRIMEL para inducir maduración en células dendríticas. Para este fin, las fracciones se obtuvieron mediante gradiente de densidad con MTBE (Metil-terbutil-éter) y se usaron para estimular DCs generadas en base a rhIL-4 y GM-CSF. En estas condiciones se evaluó la presencia de diversas moléculas de superficie y la producción de citoquinas. Para evaluar la capacidad de estas DCs de activar células iNKT, desde PBMC se aisló la población CD3+ mediante cell-sorting y cultivadas con distintas DCs generadas. Se analizó la proliferación celular utilizando el ensayo CFSE. También se evaluó la presencia de células iNKT mediante inmunofluorescencia en tacos de parafina de las DTH realizadas a pacientes de inmunoterapia. Resultados: Encontramos infiltración por células iNKT en todos los estadíos de la enfermedad, siendo mayor en Breslow avanzados, sin una correlación con la sobrevida global. Al evaluar la maduración de DCs, esta fue mayor en el grupo estimulada con la fracción peptídica de TRIMEL. DCs estimuladas con la fracción glicolipídica de TRIMEL no mostraron diferencias con la condición no tratada. Al evaluar mediante ensayo de proliferación realizado con CFSE, se evidenció mayor proliferación en la condición tratada con la fracción peptídica. Finalmente, sólo en 1 de 3 pacientes en los que se analizó la presencia de iNKT en las DTH se encontraron estas células. Conclusiones: unificando todos los hallazgos discutidos previamente, células iNKT infiltran tumores de melanoma, las que podrían ser inducidas a proliferar por DCs estimuladas con la fracción peptídica de TRIMEL y de esa forma migrar a sitios inflamados como representan las lesiones DTH.
Melanoma is the most aggressive skin tumor, with a growing incidence worldwide, despite of prevention strategies. Nowadays, there are several new therapies to treat it, however the overall survival continues to be low. Our lab has been studying a Dendritic Cell (DC) based immunotherapy maturated with a melanoma cell lines lysate (TRIMEL), which has increased survival up to 3 times in patients that developed a delayed type hypersensitivity response (DTH+). To this date no studies have been made regarding the non peptidic fraction of this lysate or its capability to activate a subpopulation of T Cells called iNKT cells, characterized by their ability to recognize glycolipids in a CD1d manner. Hypothesis: iNKT Cells infiltrate melanoma patient’s tumors and are capable to be activated in vitro by Dendritic cells Main Objective: To determinate the role of tumor infiltrating iNKT cells activated by matured Dendritic Cells ex vivo used in antimelanoma immunotherapy in melanoma patients Methods: The presence of tumor infiltrating iNKT Cells in primary melanoma in all of Breslow stages was evaluated by expression of TCR Vα24Jα18 by Immunofluorescence microscopy. To evaluate the capability of glycolipid and peptidic TRIMEL fraction to induce DCs maturation, they were isolated from TRIMEL using a MTBE (Metil-terbutil-ether) density gradient. Afterwards, these fractions were used to stimulate DCs generated with a rhIL-4 and GM-CSF protocol and surface molecules expression were assessed, as well as cytokine secretion. To evaluate DCs effectiveness to activate iNKT Cells’ proliferation, CD3+ population was isolated from Buffy Coats using cell-sorting technology and they were cultured with DCs. Proliferation was accessed with CFSE dye assay. Finally, DTH infiltrating iNKT cells were asessed in paraffined embedded samples by immunofluorescence microscopy. Results: We found that iNKT cells infiltrated melanoma tumors in every Breslow stage, with higher infiltration on advanced stages,with no correlation with overall survival. The peptidic fraction of TRIMEL induced higher expression of maturation related surface molecules in addition to cytokine secretion, whereas glycolipidic fraction showed no difference with the untreated condition. iNKT cell had a higher proliferation rate when cultured with DCs treated with the peptidic fraction of TRIMEL. And finally, we found the infiltration of iNKT in 1 of the 3 patients DTH. Conclusions: Taking together all the previous results, iNKT cells infiltrate melanoma Tumors, and they could be induced to proliferate by DCs stimulated with the peptidic fraction of TRIMEL and as well supporting their migration to inflamed tissues like the DTH samples.
2022
Pillera, Giuseppe Carmelo. "Trimap: social networked learning e social mapping per il terzo settore in Sicilia". Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1147.
Pełny tekst źródłaReinius, Leif. "Trim optimization of reefer vessels". Thesis, KTH, Marina system, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-162058.
Pełny tekst źródłaSchimmanz, Klaus. "Konzipieren und Bewerten von Hochpräzisions-Hybridwiderständen durch Laser-Trimm-Simulation". [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966338146.
Pełny tekst źródłaDouvris, Adrianna. "Functional Analysis of the TRIB1 Locus in Coronary Artery Disease". Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20115.
Pełny tekst źródłaMarafie, Sulaiman. "TRIM7, a novel binding protein of the mTORC2 component Sin1". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/trim7-a-novel-binding-protein-of-the-mtorc2-component-sin1(c344b542-0706-4ec0-be06-ce6683cee52e).html.
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