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Rozprawy doktorskie na temat „Tropomyosins”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 21 lutego 2023

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1

Au, Wing-han. "Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TRKB) signaling in ovarian cancer." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557947.

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Ebrahim, Seham. "Tropomyosins, N-terminal acetylation and their impact on yeast cytoskeletal function : a characterisation of novel tropomyosins from N. crassa and the N-terminal acetyltransferase, Nat3p." Thesis, Queen Mary, University of London, 2009. http://qmro.qmul.ac.uk/xmlui/handle/123456789/531.

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While the fundamental role of tropomyosins (Tms) in the maintenance of the actin cytoskeleton in yeast is established, details of their exact regulatory functions in lower eukaryotes remains to be deciphered. Here, two novel Tms have been identified from the filamentous yeast Neurospora crassa: a 161 residue protein spanning 4 actin monomers (crTm161p), and a 123 residue protein which spans 3 actin monomers (crTm123p). The latter isoform is the shortest naturally occurring Tm known. The isoforms are produced as a result of alternative splicing from a single gene- a phenomenon that has not prev

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3

Vlahovich, Nicole. "The role of cytoskeletal tropomyosins in skeletal muscle and muscle disease." Thesis, View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/32176.

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Cells contain an elaborate cytoskeleton which plays a major role in a variety of cellular functions including: maintenance of cell shape and dimension, providing mechanical strength, cell motility, cytokinesis during mitosis and meiosis and intracellular transport. The cell cytoskeleton is made up of three types of protein filaments: the microtubules, the intermediate filaments and the actin cytoskeleton. These components interact with each other to allow the cell to function correctly. When functioning incorrectly, disruptions to many cellular pathway have been observed with mutations in vari

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4

Vlahovich, Nicole. "The role of cytoskeletal tropomyosins in skeletal muscle and muscle disease." View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/32176.

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Thesis (Ph.D.)--University of Western Sydney, 2007.<br>A thesis presented to the University of Western Sydney, College of Health and Science, School of Natural Sciences, in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliographies.

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5

歐穎嫻 and Wing-han Au. "Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinaseB (TRKB) signaling in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557947.

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6

Robinson, Paul John Robert. "The functional effect of disease causing mutations on thin filament regulatory proteins tropomyosin, troponin T troponin I and troponin C." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670117.

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7

Patel, Dipesh A. Root Douglas. "Luminescence resonance energy transfer-based modeling of troponin in the presence of myosin and troponin/tropomyosin defining myosin binding target zones in the reconstituted thin filament." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-9834.

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8

Kotadiya, Preeyal. "Regulation Of Osteoclast Function By Alpha Gene Tropomyosins, TM-2/3 And TM-5a/5b." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1250612152.

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9

McMichael, Brooke Kristin Trinrud. "Tropomyosin 4, myosin IIA, and myosin X enhance osteoclast function through regulation of cellular attachment structures." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1206052974.

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10

McKay, Janet A. "A feasibility and exploratory study of cardiac rehabilitation in acute coronary syndrome." Thesis, University of Stirling, 2013. http://hdl.handle.net/1893/20346.

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Background: Cardiac Rehabilitation (CR) has been shown to be effective in reducing mortality and morbidity in Coronary Heart Disease (CHD). There is a limited amount of research that evaluates the impact of menu-based CR, in patients with Acute Coronary Syndrome with Low Troponin levels (ACSLT). Aim: This thesis contains a feasibility study and an exploratory study. The feasibility study aimed to examine the feasibility of a Randomised Controlled Trial (RCT) which would test the impact of a menu-based CR programme, on individuals diagnosed with ACSLT, against standard care. This feasibility st

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11

McConnell, Mark, and Mark McConnell. "Investigating the Effects of Tropomyosin D230N and cTnT R92L on the Tropomyosin Overlap Region." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/624576.

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The progression of genetically inherited cardiomyopathies from an altered protein structure to the clinical presentation of the disease is not well understood. One of the main roadblocks to mechanistic insight remains a lack of high-resolution structural information of multiprotein complexes within the cardiac sarcomere. One example is the tropomyosin (Tm) overlap region of the thin filament that is crucial for the function of the cardiac sarcomere. To address this central question, we devised coupled experimental and computational methods to characterize the baseline function and structure o

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12

Clark, Ian David. "Coupled structural responses in tropomyosin." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30625.

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Fluorescence spectroscopy can be used to probe protein conformation and is recognized as a technique that provides very specific information. It has been applied/ in recent years/ to the study of tropomyosin (TM) and its role in regulation of contractile processes. In this thesis, two different approaches were used to further the understanding of the structure/function relationship in the two chain coiled coil of tropomyosin. The first involves a comparative study on TM and non-polymerizable TM (NPTM) (Mak, A.S., and Smillie, L.B. (1981) Biochim. Biophys. Res. Commun., 101, 208-214). Fluoresce

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13

Had, Laurence. "Tropomyosines et développement du système nerveux." Montpellier 2, 1994. http://www.theses.fr/1994MON20051.

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Dans le systeme nerveux du rat, de nombreuses isoformes de tropomyosine, proteine qui stabilise les microfilaments d'actine, ont ete caracterisees au niveau de leur messager. Nous avons montre, par northern blot d'arn extraits de cultures pures, la presence d'un equipement en tropomyosine particulier dans chaque type de cellule du systeme nerveux, neurone (tm-4, tmbr-3), astrocyte (tm-4, tm-1, tm-2, tm-5a, tmbr-1 et tmbr-2) et oligodendrocyte (tm-4, tmbr-2). L'expression de ces isoformes est regulee de facon differentielle pendant la maturation. Dans les neurones, in vitro comme in vivo, tm-4

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14

Kalyva, Athanasia. "Tropomyosin heterodimers in cardiac muscle regulation." Thesis, University of Kent, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508567.

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15

Boussouf, Sabrina Eida. "Regulation of cardiac muscle contraction : effect of tropomyosin isoform expression and cardiomyopathy mutations in tropomyosin and troponin." Thesis, University of Kent, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408903.

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16

Sheikh, Hajer Nisar. "Tropomyosin Phosphorylation in Cardiac Health and Disease." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242913472.

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17

Kreuz, Andrew Joseph. "Characterization of tropomyosin mutants in Drosophila melanogaster /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487843688958564.

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18

Lendner, Matthias. "Functional analysis of tropomyosin of parasitic nematodes." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16137.

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Parasitische Würmer gehören mit über 3,5 Milliarden Betroffenen zu den weltweit verbreitetesten Infektionskrankheiten. Der Erfolg dieser Parasiten beruht auf ihren ausgefeilten Mechanismen mit denen sie das Immunsystem ihrer Wirte manipulieren. Interessanter Weise gehen Wurminfektionen mit einer geringeren Wahrscheinlichkeit an Allergien zu erkranken einher. Wie genau die Parasiten das Immunsystem manipulieren ist weitgehend unbekannt. Um diese Mechanismen besser studieren zu können, wurde im Rahmen dieser Arbeit versucht RNA interference (RNAi), anhand des Modellmoleküls Tropomyosin zu etab

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19

Janco, Miroslav. "Characterisation of tropomyosin heterodimers carrying single cardiomyopathy mutations." Thesis, University of Kent, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655655.

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It is known that different point mutations in α-tropomyosin (Tm) can cause either hypertrophic (HCM) or dilated (DCM) cardiomyopathy. Both of these serious pathologies have a distinct phenotype with unknown mechanisms of development. Biochemical in vitro studies provide valuable information for exploring downstream consequences of cardiomyopathy mutations in sarcomeric proteins leading to cardiac remodelling and consequent heart failure. Tm is a linear a-helical coil-coiled dimer involved in calcium dependent regulation of muscle contraction. Prior to this work, the effects of mutations in Tm

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20

Le, Sommer Caroline. "Identification de facteurs régulant en trans la maturation différentielle de la région 3' terminale de l'ARN pré-messager tropomyosine α chez Xenopus laevis". Rennes 1, 2006. http://www.theses.fr/2006REN1S009.

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Nous utilisons le gène de la tropomyosine  de xénope comme modèle moléculaire pour étudier les déterminants de la régulation tissulaire de l'épissage et de la polyadénylation. Ce gène contient dans sa région 3' terminale un exon alternatif, l'exon 9A9', dont l'utilisation, dans l'embryon de xénope, est dépendante de l'environnement tissulaire. Deux séquences, l'une inhibitrice l'autre activatrice, qui régulent l'épissage de cet exon, avait précédemment été identifiées. Afin de caractériser les mécanismes d'action de ces deux séquences, nous avons recherché les facteurs qui contrôlent l'utilis

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21

Lynn, Melissa L., and Melissa L. Lynn. "D230N-Tm Induced Dilated Cardiomyopathy and the Role of Fetal cTnT Isoform Switching in Modulating Disease Severity." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/625579.

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In 1980, the World Health Organization task force first sought to define and classify cardiomyopathies. They defined cardiomyopathies as "heart muscle diseases of unknown cause" with three main classifications including: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy [1]. Over the next three decades it became patently obvious that this simple definition was not sufficient to describe the complex heterogeneity of diseases present in the patient population. More robust definitions were necessary for mechanistic links to be established and meaning

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22

Heydenreich, Monika. "Phänotypische Charakterisierung von Patienten mit hypertropher Kardiomyopathie und Varianten im [beta]-MHC-Gen [beta-MHC-Gen] und [alpha]-Tropomyosin-Gen [alpha-Tropomyosin-Gen]." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965437485.

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23

Shanti, K. N. "Identification of Tropomyosin as the Major Cross-Reacting Crustacean Allergen." Thesis, Indian Institute of Science, 1994. http://hdl.handle.net/2005/103.

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Seafood including crustaceans, on ingestion, are known to provoke gastrointestinal as well as systemic allergic reactions. Crustaceans are aquatic arthropods with a chitinous exoskeleton and include shrimp, lobster, prawn and crab. Earlier studies in our laboratory have led to the identification and characterization of three allergens from shrimp, designated as Sa-I, Sa-I1 and Sa-III. The former two were shown to be heat stable proteins with a mol. wt. of 8.4 and 34 kDa respectively, while Sa-III was identified as tRNA Arg and TRNATyr ). Sa-II was found to be the major allergen contributing to

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24

Mackenzie, Cassidy. "The properties and function of tropomyosin dimers in muscle regulation." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/69463/.

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Myosin binding to actin, and thus muscle contraction, is regulated by Tropomyosin (Tpm), Troponin (Tn) and calcium (Ca2+). Tpm, is an α-helical coiled-coil dimer, which exists as a homo- or heterodimer. Two major isoforms of Tpm are found in striated muscle, α and β. Though it is known that different dimers exist, the mechanism by which they form and exchange is not fully understood. The thermal stability and exchange between dimers was explored with the use of circular dichroism and SDS PAGE densitometry analysis. Homodimers showed little exchange to form heterodimers at temperatures up to 20

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25

Asiri, Saeed Ahmed. "Effects of myopathy-causing mutations on Tropomyosin structure and function." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40307.

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Tropomyosin determinants for actin binding have not been identified completely and the nature and position of residues involved in thin filament dynamics has not been established. To date a number of Tropomyosin mutations have been linked to several muscle diseases including cardiomyopathies and skeletal muscle myopathies. In this thesis, we aimed to investigate the following tropomyosin mutations R90G, E163K, R167G, E240K, R244G and M2811 which have been shown to cause several severe skeletal muscle myopathies. We used various structural, biochemical and kinetic methods to assess the impact o

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26

Pieples, Kathy. "THE FUNCTIONAL SIGNIFICANCE OF THE STRIATED ISOFORM OF TROPOMYOSIN 3 IN NORMAL AND PATHOLOGICAL STATES." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin997992638.

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27

Graham, Ian R. "Alternative splicing of tropomyosin pre-mRNA : control in non-muscle cells." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/35232.

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Alternative splicing of tropomyosin pre-mRNA: control in non-muscle cells. Ian R. Graham The human tropomyosin gene hTMnm contains a pair of mutually exclusive exons, NM and SK, which are used in non-muscle and skeletal muscle cells, respectively. I have undertaken an analysis of the factors affecting the splicing of these exons in the non-muscle cell line COS-1. I used a strategy involving mutation of the gene, followed by recloning of the appropriate region into a mammalian expression vector containing a tropomyosin cDNA clone. The wild-type and mutant mini-genes were transfected into the ce

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28

Clayton, Joseph Emerson. "Barcoding the actin track: Differential regulation of myosin motors by tropomyosin." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/638.

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Myosins and tropomyosins represent two types of actin filament-associated proteins that often work together in contractile and motile processes in the cell. While the role of thin filament troponin-tropomyosin complexes in regulating striated muscle myosin II is well characterized, the role of tropomyosins in non-muscle myosin regulation is not well understood. Fission yeast has recently proved to be a useful model with which to study regulation of myosin motors by tropomyosin owing to its tractable genetics, well-defined actin cytoskeleton, and established actin biochemistry. A hallmark of ty

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29

Sereda, Michal Janusz. "Characterization of the molecular and immunological properties of Acanthocheilonema viteae tropomyosin." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15882.

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Diese Arbeit beschreibt die immunologischen Eigenschaften von Acanthochilonema viteae Tropomyosin, einem Muskel-assoziierten Protein. A. viteae ist ein zu den Filarien gehörender Parasit von Gerbilen, ähnlich dem humanpathogenen Filarie Onchocercha volvulus. Diese Arbeit hatte die funktionelle Charakterisierung von A. viteae Tropomyosin im Kontext der natürlichen Infektion und experimentellen Vakzinierung zum Ziel. Das allergene Potential des Tropomyosins und die Produktion von spezifischen IgE-Antikörpern wurden untersucht. Außerdem wurden Tropomyosin-spezifische monoklonale Antikörpern (mAk)

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30

Clark, Ian David. "A fluorescence study of the COOH-terminus region of equine platelet tropomyosin." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26190.

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The use of fluorescent molecules as probes of protein conformation is recognized as a technique which provides very specific information and has been applied, in recent years, to the study of the role of tropomyosin (TM) in the regulation of contractile processes. The isolation and sequencing of TM from horse blood platelets (P-TM) has shown it to be different from muscle TM, especially near the NH₂-and COOH-termini. These differences have been suggested to weaken end-to-end interaction of P-TM molecules. TM's are two chain coiled coils and P-TM has cysteine residues at the penultimate COOH-te

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31

Coles, J. L. "The regulation of a novel exon in the rat α-tropomyosin gene". Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597846.

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A conserved novel exon has been identified downstream of exon 3 of the rat α-tropomyosin gene. Inclusion of this exon is predicted to result in nonsense mediated decay of the α-tropomyosin transcript due to the presence of premature termination codons. Previous work showed that this nonsense exon is readily activated by a number of mutations in the 3’splice site and the 5’ end of the exon. Furthermore, there is evidence that the nonsense exon is activated in kidney, heart and lung tissue, indicating that its inclusion may be regulated in a tissue-specific manner. In this study, several computa

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32

Fairhead, Giles. "The interactions of Troponin T with Troponin C, Troponin I and Tropomyosin." Thesis, University of Birmingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422010.

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33

Taylor, Claire Frances. "The regulation of splicing of the human alpha sigma-tropomyosin pre-mRNA." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/35167.

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The human alpha-s-tropomyosin pre-mRNA, encoded by the hTMnm gene, is alternatively spliced. In skeletal muscle cells, amino acids 189-213 are encoded by a skeletal-muscle specific exon, called SK. In all other cell types, amino acids 189-213 are encoded by an alternative exon called NM. The pattern of splicing of SK and NM is mutually exclusive. Previous work had shown that in non-muscle cells, the selection of NM was determined by the intrinsic inactivity of the SK exon. SK inactivity was believed to be due to non-muscle-specific repression of the SK exon. The principal cis-acting sequence m

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34

Pasquet, Stéphanie. "Etude de la régulation transcriptionnelle du gène alpha-tropomyosine dans les cellules musculaires." Bordeaux 2, 2003. http://www.theses.fr/2003BOR21036.

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Nous avons étudié la régulation de la transcription du gène alpha-tropomyosine (TM) dans les cellules musculaires lisses (CML), squelettiques et cardiaques en culture. Les séquences régulatrices C-rich et MCAT activent la transcription dans les trois types cellulaires. Le trans-facteur TEF-1, qui lie la séquence MCAT, joue un rôle majeur dans la régulation de la transcription dans les trois types de muscles. Le facteur SRF interviendrait de façon indirecte, dans les CML et les cardiomyoctes, en augmentant la liaison de TEF-1 sur la boîte MCAT, et directement dans les myoblastes squelettiques e

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35

Marknell, DeWitt Åsa. "Use of recombinant allergens for component-resolved diagnostics (CRD) in IgE-mediated allergy /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7813.

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Schulz, Emily M. "To Phosphorylate or Not to Phosphorylate: The Role of Tropomyosin Phosphorylation in Cardiac Function and Disease." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1355156757.

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Halsall, D. J. "The effects of troponin and tropomyosin on rabbit skeletal actomyosin subfragment 1 interactions." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378788.

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Gaillard, Catherine. "Le gene alpha-tropomyosine chez xenopus laevis : organisation et etude de son controle transcriptionnel." Rennes 1, 1996. http://www.theses.fr/1996REN10152.

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L'objectif de ce travail a ete de caracteriser la structure du gene alpha-tm de xenope et d'etudier les modalites de son controle transcriptionnel au cours du developpement. L'analyse de deux clones genomiques nous a permis de montrer que la structure de la region 5' du gene etait conservee par rapport aux genes aviaires et mammiferes. Cette region possede deux promoteurs et le couple d'exons alternatifs 2a/2b. Nous avons montre que l'exon 2a etait specifiquement utilise dans les cellules musculaires lisse. Par une approche utilisant la pcr, nous avons etablit la structure partielle du gene et

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39

Hamon, Gouault Sandra. "Etude de la maturation différentielle du gène alpha-fast tropomyosine chez xénopus Laevis : identifications d'éléments en cis régulant l'utilisation d'un exon composite interne/3' terminal." Rennes 1, 2002. http://www.theses.fr/2002REN10046.

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L'exon 9A/9' du gène de l'alpha-tropomyosine de Xenopus laevis est utilisé en tant qu'exon 3' terminal dans les cellules musculaires embryonnaires ou en tant qu'exon interne dans les muscles striés embryonnaires et adultes. Il est par contre exclu dans les cellules non musculaires. L'exon 9A/9' se caractérise par des sites d'épissage et un signal de polyadénylation suboptimaux ainsi que par un point de branchement éloigné situé à 274 pb en amont du site d'épissage 3'. Une approche par transgenèse transitoire dans l'embryon a permis de mettre en évidence deux éléments régulateurs chevauchants e

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40

Grellscheid, S. N. "The role of cis-acting sequences in the regulation of α-tropomyosin alternative splicing". Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599698.

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The main investigation was a study of the possible role of a zero length exon (ZLE) observed 234 nucleotides downstream of exon 3, in α-TM splicing. The ZLE overlaps with the DRE, and consists of potential branchpoints, a polypyrimidine tract and a 3’ splice site (3’ss) GAG, followed immediately by a 5’ splice site (5’ss). In addition, a pseudo 5’ss is located 107 nucleotides downstream of the 3’ss. All of these sequences are conserved between rat mouse and human α-TM genes. While the initial aim was to study the role of the ZLE, results from this study suggest that the ZLE is part of a 107 nu

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41

Holeman, Teryn A., та Teryn A. Holeman. "Effects of Three Cardiomyopathic-Causing Mutations (D230N, D84N, and E62Q) on the Structure and Flexibility of α-Tropomyosin". Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/624101.

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Cardiac contraction at the level of the sarcomere is regulated by the thin filament (TF) composed of actin, alpha tropomyosin (TPM), and the troponin (Tn) complex (cTnT: cTnC: cTnI). The "gate-keeper" protein, α-TPM, is a highly conserved α-helical, coiled-coil dimer that spans actin and regulates myosin-actin interactions. The N-terminus of one α-TPM dimer inter-digitates with the C-terminus of the adjacent dimer in a head-to-tail fashion forming the flexible and cooperative TPM-overlap that is necessary for myofilament activation. Two dilated cardiomyopathy (DCM) causing mutations in TPM (D8

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42

Nadal, Magriñà Laura. "Muscarinic, adenosine and tropomyosin-related kinase B receptors modulate the neuromuscular developmental synapse elimination process." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/441749.

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El desenvolupament del sistema nerviós perifèric implica una inicial exuberant producció de neurones i, una posterior reducció dependent de l'activitat del nombre de sinapsis de les unions neuromusculars (NMJ). Aquest procés s’anomena eliminació sinàptica. Al final de la primera setmana postnatal, cada fibra muscular està innervada per una sola motoneurona. Els receptors muscarínics d’acetilcolina (mAChR), els receptors d’adenosina (AR) i el receptor cinasa de tropomiosina B (TrkB) podrien permetre la competició entre terminals nerviosos durant el procés d’eliminació sinàptica mitjançant la mo

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Ly, Thu, Natalia Moroz, Christopher T. Pappas, Stefanie M. Novak, Dmitri Tolkatchev, Dayton Wooldridge, Rachel M. Mayfield, Gregory Helms, Carol C. Gregorio, and Alla S. Kostyukova. "The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2's function." AMER SOC CELL BIOLOGY, 2016. http://hdl.handle.net/10150/621526.

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Leiomodin is a potent actin nucleator related to tropomodulin, a capping protein localized at the pointed end of the thin filaments. Mutations in leiomodin-3 are associated with lethal nemaline myopathy in humans, and leiomodin-2-knockout mice present with dilated cardiomyopathy. The arrangement of the N-terminal actin- and tropomyosin-binding sites in leiomodin is contradictory and functionally not well understood. Using one-dimensional nuclear magnetic resonance and the pointed-end actin polymerization assay, we find that leiomodin-2, a major cardiac isoform, has an N-terminal actin-binding

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BALVAY, LAURENT. "Etude de la regulation de l'epissage des exons alternatifs 6a et 6b des genes de tropomyosine." Paris 7, 1994. http://www.theses.fr/1994PA077007.

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La plupart des genes codant pour des proteines eucaryotes sont divises en introns et en exons. L'epissage permet de passer de la structure morcelee de l'information codante sur l'adn (exons) a la sequence des arns messagers. Ce processus se complique quand un meme gene comporte plusieurs exons potentiels pouvant engendrer plusieurs types de transcrits. On parle alors d'epissage alternatif. La diversite des isoformes de tropomyosine chez les vertebres est essentiellement generee par des phenomenes d'epissage alternatifs. Quatre genes sont ainsi a l'origine de plus d'une vingtaine d'isoformes ch

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Hardy, Serge. "Caracterisation d'adn complementaires tropomyosines chez le xenope. Expression et modeles d'organisation des genes alpha et beta." Rennes 1, 1991. http://www.theses.fr/1991REN10014.

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Les tropomyosines existent sous de nombreuses isoformes specifiques d'un tissu. Cette diversite est due a l'existence de plusieurs genes mais aussi a la synthese d'isoformes multiples a partir d'un meme gene par l'utilisation de promoteurs multiples et d'exons alternatifs. Nous avons entrepris une etude sur l'organisation des genes tropomyosines chez le xenopedans l'objectif d'utiliser l'ovocyte et l'embryon de xenope pour une etude in vivo des regulations transcriptionnelles et post-transcriptionnelles des genes tropomyosines. En criblant des banques d'adnc d'embryons et d'ovocytes de xenope

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Heydenreich, Monika. "Phänotypische Charakterisierung von Patienten mit hypertropher Kardiomyopathie und Varianten im Beta-MHC-Gen und Alpha-Tropomyosin-Gen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/14777.

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Die hypertrophe Kardiomyopathie ist eine autosomal dominant vererbte Herzmuskelerkrankung. Es kommt zu einer asymmetrischen Hypertrophie insbesondere des Herzmuskels. Symptome sind unspezifisch und reichen von Dyspnoe bis hin zu Synkopen. Gelegentlich ist der plötzliche Herztod die erste Manifestation der Erkrankung. Molekulargenetische Untersuchung des Genomes dieser Patienten zeigten, dass diese Patienten Mutationen im Proteinen des Sarkomers aufwiesen. Hierunter fällt das beta-MHC-Gen und alpha-Tropomysin-Gen. Wir untersuchten 45 nicht miteinanderverwandte Patienten auf Mutationen im beta

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Harder, Megan Michelle. "Morphological Changes Associated with Severe Early Onset Dilated Cardiomyopathy Caused by a Mutation in Alpha Tropomyosin." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579427.

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A point mutation in alpha tropomyosin (Tm) Asp230Asn (D230N) has been found in two unrelated multigenerational families to be causative for dilated cardiomyopathy (DCM). In these families, a distinct "bimodal" distribution of severity was observed whereby children have a severe DCM and adults have a mild to moderate phenotype. If children harboring this mutation survive the initial presentation of DCM, they often regain some systolic function. This "bimodal" presentation led us to ask what changes occur in the heart between fetal and postnatal life that could account for this; a potential cand

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Naye, François. "Caractérisation et rôle de TEF-1 au cours du développement embryonnaire de Xenopus Laevis." Bordeaux 2, 2007. http://www.theses.fr/2007BOR21467.

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Caractérisation et rôle de TRF-1 au cours du développement embryonnaire de Xenopus Levis. L'étude de la régulation du gène α-tropomyosine (α-TM)de xénope a permis d'identifier une région régulatrice de 30 pb dans la région promotrice du gène. Cette région est très conservée entre les différents gènes α-TM de vertébrés et possède une séquence MCAT (5' -CATTCCT-3') essentielle pour l'activité du gène dabs les trois lignages musculaires. Cette séquence fixe le facteur de transcription TEF-1. L'analyse par transgenèse a montré que l'expression spatiotemporelle correcte du gène α-TM dans l'embryon

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LIBRI, DOMENICO. "Caracterisation du gene codant pour l'isoforme beta de la tropomyosine chez le poulet. Etude de l'epissage alternatif." Paris 11, 1990. http://www.theses.fr/1990PA112069.

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Le gene codant pour l'isoforme beta de la tropomyosine a ete isole et caracterise. Ce gene est soumis a l'epissage alternatif. Deux exons (6a et 6b) sont utilises de facon mutuellement exclusive et sont specifiques respectivement des cellules non musculaires/muscle lisse et du muscle squelettique. Des minigenes contenant les deux exons alternatifs entoures par deux exons constitutifs ont ete utilises pour transfecter des cellules myogeniques. L'etude du controle de l'epissage a ete poursuivi en introduisant des mutations dans la region de l'exon 6b. Cela nous a permis d'identifier un certain n

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Zhao, Rathje Li-Sophie. "Tropomyosin in Normal and Malignant Cells and the Action of Picropodophyllin on the Microfilament and Microtubule Systems." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-27767.

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Cell motility is a fundamental process, enabling cells to migrate, for instance during embryogenesis, tissue repair and defense. Force is generated by two protein systems, which also participate in cell proliferation, control macromolecular and organelle distribution and determine the fine structure of the cell interior. The major components of these are actin and tubulin, respectively, and they are referred to as the microfilament and the microtubule systems. This thesis focuses on tropomyosin, one of many microfilament associated proteins coupled to actin dynamics and organization and expres

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