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Rozprawy doktorskie na temat „Tumor necrosis factor Physiological effect”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 28 stycznia 2023

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1

Atkinson, Yvelle Hope. "Regulation of neutrophil functions by tumor necrosis factor-alpha /." Title page, contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09PH/09pha878.pdf.

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Caughey, Gillian Elizabeth. "Regulation of interleukin-1[Beta] and tumor necrosis factor[alpha] synthesis by fatty acids and eicosanoids /." Title page, table of contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phc371.pdf.

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Penglis, Peter Savas. "The relationships between eicosanoid production and pro-inflammatory cytokines." Title page, contents and summary only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09php3985.pdf.

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Includes bibliographical references (leaves 182-240). Explores alternate strategies that may alter inflammatory cytokine production, particularly tumour necrosis factor đ [tumor necrosis factor-alpha], and therefore provide a possible treatment for rheumatoid arthritis.

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Berry, Mark P. McMurray Robert G. "The effect of exercise in the heat on circulating tumor necrosis factor-[alpha] concentration." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1878.

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Thesis (M.A.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Master of Arts in the Department of Exercise and Sport Science Exercise Physiology." Discipline: Exercise and Sports Science; Department/School: Exercise and Sport Science. On t.p. and in abstract, [alpha] is Greek letter.

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Lo, Susan Z. Y. "NF-kB- and mitochondria-linked signaling events that contribute to TNFa action in deferring physiological and chemotherapeutic drug-induced apoptosis in macrophages." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0095.

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TNF defers apoptosis in macrophages undergoing spontaneous or pharmacologically (thapsigargin, ceramide, CCCP, etoposide or cisplatin)-induced apoptosis, as determined by measurements of caspase-3 activity and annexin-V staining (Chapter 2). The action requires TNF interaction with TNF-R1, not TNF-R2. Survival is uniquely reliant on the activity of the NF-B signaling pathway, and does not require activities arising from the PI3K/Akt, JNK, ERK, p38 MAP kinase or iNOS pathways (Chapter 3). Further, the general anti-apoptotic property of TNF and its specific antagonism of CCCP-induced apoptosis l

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6

Salimi-Ghezelbash, Afsar. "In vitro effect of recombinant interferon gamma and tumor necrosis factor alpha on killing of entamoeba histolytica trophozoites by murine macrophages." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61236.

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The present study examines the role of liver macrophages (Kupffer cells), of C57BL/6 mice, as effector cells responsible for the killing of Entamoeba histolytica trophozoites in vitro. Interferon gamma (IFN-$ gamma$) and tumor necrosis factor alpha (TNF) were each shown to endow murine Kupffer cells with significant amoebicidal activity. Interferon gamma alone was not able to activate Kupffer cells to amoebicidal state. However, IFN-$ gamma$ and lipopolysaccharide (LPS) acted synergistically in this phenomenon. It seems that the acquisition of amoebicidal activity is associated with the involv

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7

Molgat, André. "The Effect of Macrophage-secreted Factors on Preadipocyte Survival." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23628.

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Adipose tissue (AT) expansion and remodeling that maintains healthy function relies on stromal preadipocytes capable of differentiating into new adipocytes (adipogenesis). During chronic positive energy balance, a relative deficit in adipogenesis, from either a decrease in preadipocyte number or their capacity to differentiate, leads to excessive adipocyte hypertrophy and AT dysfunction. AT contains macrophages whose number and activation state is dynamically regulated with changes in AT mass. This study aims to investigate the effect of macrophage-secreted factors on preadipocyte survival. To

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8

Farrow, Michael John. "The effect of androstenediol on gene expression and NF-kappaB activation in vitro." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187109346.

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Albuquerque, Assis Filipe Medeiros. "Effect of preemptive analgesia on tissue levels of interleukin-1 beta and tumor necrosis factor alpha in third molar surgery: a triple-blinded randomized placebo-controlled study." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16231.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A cirurgia para remoÃÃo de terceiros molares constitui-se um procedimento frequentemente realizado em odontologia, estando associado a variados graus de dor pÃs-operatÃria, podendo afetar a qualidade de vida dos pacientes. Considerando o benefÃcio mÃximo ao paciente submetido a uma cirurgia, insere-se a analgesia preemptiva como estratÃgia farmacolÃgica amplamente pesquisada nas Ãltimas dÃcadas. O objetivo do presente estudo foi avaliar o efeito da analgesia preemptiva sob os efeitos inflamatÃrios e sob os nÃveis de citocinas prÃ

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Farrow, Michael John. "The effect of androstenediol on gene expression and NF-κB activation in vitro". The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1187109346.

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Vieira, Cristiano Pedrozo 1986. "Efeito da nutrição terapêutica a base de Camellia sinensis (chá verde) e ração rica em glicina sobre a tendinite do tendão calcanear de rato = Effect of therapeutic nutrition on the basis of Camellia sinensis (green tea) and glycine-diet on the tendinitis of Achilles tendon of rats." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317356.

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Orientador: Edson Rosa Pimentel<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-26T15:25:06Z (GMT). No. of bitstreams: 1 Vieira_CristianoPedrozo_D.pdf: 3245048 bytes, checksum: 0556c35183a4503cef8427390d086781 (MD5) Previous issue date: 2015<br>Resumo: Nutrição terapêutica é a administração de alguns nutrientes, em doses maiores que as necessidades alimentares diárias que podem prevenir deficiências orgânicas e atuar como agentes farmacológicos. A glicina apresenta amplos efeitos benéficos em processos inflamatórios e tumo

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12

Barbara, Jeffrey A. J. (Jeffrey Allan J. ). "The mechanism of action of tumour necrosis factor-[alpha] / Jeffrey A.J. Barbara." 1995. http://hdl.handle.net/2440/18552.

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Amendments inserted inside front cover.<br>Bibliograpghy: leaves 111-139.<br>xvi, 139, [29] leaves, [10] leaves of plates : ill. ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>The in vivo adminstration of Tumour Necrosis Factor-alpha as an antineoplastic agent has been severely restricted by dose-limiting side effects. Human TNF mutants with selective binding to the Human TNF receptors were employed to examine the role of these receptors in the mediation of TNF's cytotoxic and proinflammatory activities.<br>The

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Barbara, Jeffrey A. J. (Jeffrey Allan J. ). "The mechanism of action of tumour necrosis factor-α / Jeffrey A.J. Barbara". Thesis, 1995. http://hdl.handle.net/2440/18552.

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Amendments inserted inside front cover.<br>Bibliograpghy: leaves 111-139.<br>xvi, 139, [29] leaves, [10] leaves of plates : ill. ; 30 cm.<br>The in vivo adminstration of Tumour Necrosis Factor-alpha as an antineoplastic agent has been severely restricted by dose-limiting side effects. Human TNF mutants with selective binding to the Human TNF receptors were employed to examine the role of these receptors in the mediation of TNF's cytotoxic and proinflammatory activities.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1995?

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14

Atkinson, Yvelle Hope. "Regulation of neutrophil functions by tumor necrosis factor-alpha / by Yvelle Hope Atkinson." Thesis, 1989. http://hdl.handle.net/2440/18993.

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Ng, Esther Mei Ther. "The biological role of membrane tumour necrosis factor in inflammation and infection." Phd thesis, 2009. http://hdl.handle.net/1885/148364.

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Penglis, Peter Savas. "The relationships between eicosanoid production and pro-inflammatory cytokines." Thesis, 2001. http://hdl.handle.net/2440/111707.

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Explores alternate strategies that may alter inflammatory cytokine production, particularly tumour necrosis factor α [tumor necrosis factor-alpha], and therefore provide a possible treatment for rheumatoid arthritis.<br>Thesis (Ph.D.) -- University of Adelaide, Dept. of Medicine, 2001

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17

Gamble, Jennifer R. "Regulation of leukocyte adhesion to endothelium / by Jennifer Ruth Gamble." 1994. http://hdl.handle.net/2440/21552.

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Copies of author's previously published articles inserted.<br>Includes bibliographical references.<br>vii, 39 leaves : ill. ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Shows that the cytokine tumour necrosis factor [alpha] (TNF-[alpha]) enhances the adhesion of neutrophils to the endothelium by an action both on the neutrophil and on the endothelial cell.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1995?

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Gamble, Jennifer R. "Regulation of leukocyte adhesion to endothelium / by Jennifer Ruth Gamble." Thesis, 1994. http://hdl.handle.net/2440/21552.

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Copies of author's previously published articles inserted.<br>Includes bibliographical references.<br>vii, 39 leaves : ill. ; 30 cm.<br>Shows that the cytokine tumour necrosis factor [alpha] (TNF-[alpha]) enhances the adhesion of neutrophils to the endothelium by an action both on the neutrophil and on the endothelial cell.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1995?

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19

Yu, Seok-Yeong. "Effect of Obesity-Induced Tumor Necrosis Factor Alpha on Adipocyte Function." 2016. https://scholarworks.umass.edu/masters_theses_2/389.

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Obesity-induced inflammation has been linked to the onset of insulin resistance (IR), which is a strong risk factor for the development of T2DM. Recent studies have indicated that tumor necrosis factor alpha (TNFα) plays a causative role in obesity-mediated IR via its overexpression in adipose tissue. Moreover, TNFα has been shown to induce the IR and the alteration of lipid and glucose metabolism in adipose tissue at various levels including normal adipocyte differentiation and mature adipocyte function. However, the mechanisms linking TNFα-induced adipocyte dysfunction in chronic obesity to

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20

"Effect of combined treatment of tumor necrosis factor-alpha and hyperthermia on human and murine tumor cells." 1998. http://library.cuhk.edu.hk/record=b5889720.

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by Lam Kai Yi.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1998.<br>Includes bibliographical references (leaves 156-165).<br>Abstract also in Chinese.<br>Chapter Chapter One: --- Introduction --- p.1<br>Chapter 1.1 --- Tumor Necrosis Factor-α in Cancer Treatment --- p.1<br>Chapter 1.1.1 --- Historical Background --- p.1<br>Chapter 1.1.2 --- Mechanisms of Action --- p.2<br>Chapter 1.1.2.1 --- Production of Reactive oxidative Species<br>Chapter 1.1.2.2 --- Increase of Intracellular Free Calcium Concentration<br>Chapter 1.1.2.3 --- Activation of Ca2+/Mg2+-dependent Endonuclease<br>C

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21

Tsai, I.-Ting, and 蔡伊婷. "Effect of andrographolide on tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression in EA.hy926 cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/22918056701239072268.

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碩士<br>中國醫藥大學<br>營養學系碩士班<br>98<br>Several lines of evidence indicate that inflammation and endothelial cell dysfunction are important initiating events in atherosclerosis. Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, induces the expression of cell adhesion molecules and results in monocyte adherence and atheromatous plaques formation. Andrographolide (AP) is a major bioactive diterpene lactone in Andrographis paniculata, which possesses anti-inflammatory property. In the present study, we investigated the effect of AP on TNF-α-induced ICAM-1 expression in EA.hy926 cells. AP inhi

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22

Chen, Pai-Gene, та 陳姵君. "Cooperative Effect of Interferon－γ and Tumor Necrosis Factor－α on the Induction of Differentiation in Human Leukemic NB4 Cells". Thesis, 1996. http://ndltd.ncl.edu.tw/handle/85209129824183164562.

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Sofio, Ana Rita Durão da Graça Godinho. "The effect of exercise and tumor necrosis factor inhibitor on peripheral and axial inflammation in an animal model of spondyloarthritis." Master's thesis, 2019. http://hdl.handle.net/10451/42204.

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Tese de mestrado, Ciências Biofarmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019<br>A espondilite anquilosante é a mais comum entre as doenças espondiloartriticas e tem uma prevalência entre 1,0-1,4% na população mundial, e 1,6% entre a população de Portugal. A patogénese da EA inclui sinovite, entesite com mecanismos controversos do desenvolvimento da doença que são caracterizados por uma formação óssea local excessiva, também associada à perda sistémica óssea. A inflamação articular resulta em inchaço que causa dor, perda de mobilidade, rigidez articular e danos ósseos. Atual

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24

Sud, Reeteka. "Brain-derived tumor necrosis factor-alpha (TNF) mediates the antinociceptive effect of amitriptyline and modulates brain-body interactions during neuropathic pain." 2005. http://proquest.umi.com/pqdweb?did=888850581&sid=5&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (Ph.D.)--State University of New York at Buffalo, 2005.<br>Title from PDF title page (viewed on May 12, 2006) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Spengler, Robert N., Ignatowski, Tracey A. Includes bibliographical references.

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Hsing-Chin and 朱倖槿. "Effect of andrographolide on tumor necrosis factor-alpha-induced expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/27594582421906971910.

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碩士<br>中山醫學大學<br>營養學研究所<br>97<br>Atherosclerosis is an inflammatory disease in which the early stages of atherosclerosis are initiated by accumulation of oxLDL and activation of endothelial cells with subsequent expression of adhesion molecules and increased recruitment of leukocytes to the vascular endothelium. It is reported that stimulation of macrophages with oxLDL leads to enhanced TNF-α secretion. TNF-α is an inflammatory cytokine, and this implicates that oxLDL is an inflammatory stimulus. Andrographolide is a diterpene lactone isolated from the leaves of the Andrographis paniculata, whi

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Pan, Szu-jung, та 潘思融. "Effect of high concentration glucose and/or tumor necrosis factor-α on the oxidative stress of human hepatocellular carcinoma cell line". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/94050030880049911375.

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碩士<br>靜宜大學<br>食品營養研究所<br>98<br>Hyperglycemia which major characterizes diabetes, may be related to inflammation and oxidative stress. Inflammation and oxidative stress were of the major risk factor for diabetic complications. The purpose of this study was to investigate the effect of high glucose or inflammation on the cell injury and oxidative stress of liver cell. Human hepatocellular carcinoma cell line (HepG2) was cultured with (5, 10, 15, 25, 35 mM) glucose and/or 0, 0.1, 1, 10, 20 ng/ml tumor necrosis factor-α (TNF-α) in the experiment. Cell viability, nitrite content, MDA content, for 2

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Hsieh, Li-Yuan, and 謝笠元. "The effect of statins on thrombomodulin expression in tumor necrosis factor-alpha-treated human aortic endothelial cells and its underlying mechanisms." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/65046596155909855759.

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碩士<br>國立陽明大學<br>解剖暨細胞生物學研究所<br>93<br>Recent large clinical trials have demonstrated that statin（HMG-CoA reductase inhibitor）, markedly reduces morbidity and mortality when used in the primary and secondary prevention of cardiovascular diseases not only by its lipid-lowering potential but also by its nonlipid-related mechanism. It has been reported that statins can counteract TNF-alpha induced downregulation of thrombomodulin（TM）, which plays a critical role in both anticoagulation and anti-inflammation. In this study, Human Aortic Endothelial Cells（HAECs） pretreated with these two different st

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Lim, Amber Hyesuk. "The protective effect of fat specific protein 27 on tumor necrosis factor-alpha induced lipolysis and insulin resistance in human adipocytes." Thesis, 2015. https://hdl.handle.net/2144/13946.

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Adipose tissue is a key regulator of energy metabolism and glucose homeostasis by promoting triglyceride storage and breakdown in various physiological states. Obesity, however, alters adipose tissue metabolism, inducing chronic inflammation, followed by excessive lipolysis. This results in higher systemic free fatty acid (FFA) levels, leading to desensitization of insulin signaling and ultimately to insulin resistance. Although the link between obesity and progression of insulin resistance and type 2 diabetes mellitus (T2DM) remains unclear, tumor necrosis factor-alpha (TNF-alpha) has been pr

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Siska, Karla P. "Anti-inflammatory Effect of Vigna Unguiculata Polyphenols in Raw 264.7 Macrophages." Thesis, 2013. http://hdl.handle.net/1969.1/149934.

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This study investigated the association between flavonoid profiles of different cowpea (Vigna Unguiculata) varieties with anti-inflammatory properties as a possible benefit against inflammatory bowel disease. Cowpea, a drought tolerant annual herbaceous legume that originated in Africa, is known to possess high levels of polyphenolics, which have demonstrated anti-inflammatory, immunoregulatory and antioxidant properties. Black, red, white, brown and light brown cowpeas were investigated for phenolic content and composition using UV-Visible Spectroscopy and HPLC; antioxidant activation mechan

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Kent, Leigh Whitfield. "Effect of microbial lipopolysaccharide and inflammatory cytokines on IL-6 induction by human gingival fibroblasts from healthy and periodontally diseased tissue." 1997. http://catalog.hathitrust.org/api/volumes/oclc/48180572.html.

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Thesis (Ph. D.)--University of Alabama at Birmingham, School of Joint Health Sciences, 1997.<br>eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

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Yang, Shih-Liang, and 楊士樑. "Effect of Bu-zhong-yi-qi-tang on invitro Tumor Necrosis Factor-alpha and Granulocyte Colony-stimulating-factor Produced by Peripheral Blood Mononuclear Cells in Patients with Hepatoma." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/29070787133325771272.

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碩士<br>中國醫藥學院<br>中國醫學研究所<br>86<br>Bu-zhong-yi-qi-tang (BZYQT) is the kind of popular traditional Chinese medicine, and has been used for the treatment of hepatocellular carcinoma (HCC). At present, we still do not know the effects of BZYQT on the immune system very well. The present in vitro study demonstrated that BZYQT is capable of increasing tumor necrosis factor-a (TNF-a) and granulocyte colony-stimulating-factor (G-CSF) produced by peripheral blood mononuclear cells (PBMC). The production levels of G-CSF by PBMC of health volunteers were higher than those of patients with

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Fu, Pin-Kuei, та 傅彬貴. "The study in the relationship between effect of Carthamus tinctorious L. on Ischemia-Reperfusion cerebral infarct Rats, and tumor necrosis factor-α and interleukin-1β". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/08753122800013395420.

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碩士<br>中國醫藥大學<br>中國醫學研究所<br>99<br>According to the theory of Traditional Chinese medicine, cerebrovascular accident mainly results from blood stasis. Carthamus tinctorious L. (CT) is considered that has the action of activate blood to eliminate stasis since long time ago. Several studies have known recently that CT has antioxidant, ant inflammation and inhibiting glutamate-mediated injury action, and also can protect neuronal cell in the brain. Therefore, the purpose of the present study is to investigate effect of CT on cerebral infarct. A total of 72 male Sprague-Dawley (SD) rats were studied

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Yu-Han, Huang, and 黃昱翰. "The study in relationship between anticonvulsive effect of Gastrodia elata Bl. and interleukin-1b, tumor necrosis factor-a, nitric oxide in kainic acid-induced epileptic seizure rats." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/42035484803531898941.

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碩士<br>長庚大學<br>傳統中國醫學研究所<br>92<br>In Traditional Chinese Medicine, the etiology of epileptic seizure is considered that it is due to the imbalance between Yi and Yang in the liver system, resulting in liver wind stirring internally. Therefore, the method of calm the liver to stop the wind is used to treat epileptic seizure. Gastrodia elata Bl.(GE) is one of Chinese herbs, and it is considered that has the action of calm the liver to stop the wind, and is used to treat epileptic seizure for a long period. Our previous studies have known that GE can reduce kainic acid (KA)-induced epileptic seizu

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Huang, Dong Ming, and 黃東明. "Differentiation-associated distribution of glutathione and antioxidant enzymes in human hepatoma cell lines and their relation to the preferential cellular resistance to the cytotoxic effect of tumor necrosis factor-��." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/00329349152309425511.

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