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Rozprawy doktorskie na temat „Tumors”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Monzón, Gonzales Janneth Silvana. "Tumores del intestino delgado: Perfil Clínico-Patológico, Enero 2003 a Marzo 2005, Hospital Edgardo Rebagliati Martins." Bachelor's thesis, Universidad Ricardo Palma, 2006. http://cybertesis.urp.edu.pe/handle/urp/199.

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El objetivo principal de este trabajo es definir las características clínicas de los tumores de intestino delgado según su tipo. Se revisaron retrospectivamente los archivos de anatomía patológica y los archivos de historias clínicas del Hospital Edgardo Rebagliati Martins, eligiendo los casos con diagnóstico de tumores benignos y malignos del intestino delgado, correspondientes al período de enero de 2003 a marzo de 2005. De ellos se seleccionó un total de 107 casos que cumplían con los criterios de inclusión y se estudió su historial clínico para llenar la ficha de recolección de datos. De l

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2

Swanson, Kristin Rae. "Mathematical modeling of the growth and control of tumors /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/6764.

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Cuny, Thomas. "New regulatory mechanisms in the growth of endocrine tumors : digestive neuroendocrine tumors, pitiutary adenomas." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5061.

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Bien que rares, les tumeurs endocrines développées chez l'Homme demeurent problèmatiques. Une meilleure compréhension des mécanismes qui régulent leur croissance constitue un objectif essentiel pour identifier des cibles thérapeutiques nouvelles.Dans la première partie de cette thèse, nous avons étudié l'impact du microenvironnement tumoral (MeT), définit par l'ensemble des facteurs qui encerclent la niche tumorale primitive, sur la croissance des tumeurs endocrines digestives. In vitro, nous observons un effet prolifératif réciproque entre des fibroblastes, l'une des cellules pivots du MeT, e

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Tai, Kai-chun Dora, and 戴啟真. "Krukenberg tumours of colorectal origin: experience of a tertiary referral centre and review of theliterature." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4562043X.

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Nakayama, Tomitaka. "MDM2 gene amplification in bone and soft-tissue tumors : association with tumor progression in differentiated adiposetissue tumors." Kyoto University, 1997. http://hdl.handle.net/2433/202202.

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6

Cataldo, A. "ANTI-TUMOR ACTIVITY OF CPG-ODN IN OVARIAN XENOGRAFT TUMORS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229558.

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Synthetic oligodeoxynucleotides expressing CpG motifs (CpG-ODN), Toll-like receptor 9 (TLR9) agonists, are able to induce innate/adaptive immune responses and can enhance the antitumor activity of DNA-damaging chemotherapy and radiation therapy in preclinical mouse models. It was recently reported that peritumoral CpG-ODN treatment in preclinical models of ovarian cancer, activating TLR-9 expressing cells in tumor microenvironment, induces modulation of DNA repair genes and sensitizes cancer cells to DNA-damaging Cisplatin treatment. In this thesis we investigated whether this treatment ind

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Marcu, Loredana Gabriela. "Deterministic modelling of kinetics and radiobiology of radiation-cisplatin interaction in the treatment of head and neck cancers." Title page, contents and abstract only, 2004. http://hdl.handle.net/2440/37961.

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One of the main objectives of combining radiation treatment and chemotherapy is to obtain a therapeutic gain by an improved tumour control with less or no enhancement of normal tissue toxicity. The optimal schedule for the combined treatment of cisplatin-radiation is still under investigation. Neither the optimal time interval, nor the most adequate sequence of administration of cisplatin and radiation are known. The results of the trials are also inconclusive. Some trials showed a supra-additive effect from the administration of cisplatin before radiotherapy, others, on contrary, from the inj

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8

Lu, Dan. "Tumor priming enhances particle delivery to and transport in solid tumors." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1144936804.

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9

Martinez, Mata Guillermo. "Mixomas odontogenicos : analise clinicopatologica e imunohistoquimica de 67 casos." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288397.

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Orientador: Oslei Paes de Almeida<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-05T09:05:53Z (GMT). No. of bitstreams: 1 MartinezMata_Guillermo_M.pdf: 1070617 bytes, checksum: 13db66187a1a59eeaa5b18ca3a02cb9d (MD5) Previous issue date: 2005<br>Resumo: O objetivo deste trabalho foi analisar as características clínicas, radiográficas, histopatológicas e perfil imunohistoquímico de 67 casos de mixomas odontogênicos (MOs), assim como relatar uma das casuísticas mais extensas da literatura mundial. Nest

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10

Furtado, LuÃs Edmundo Teixeira de Arruda. "IdentificaÃÃo de glicoproteÃnas em membrana de tumores primÃrios do sistema nervoso central utilizando lectinas vegetais acopladas a fluoresceÃna." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4868.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Lectinas sÃo proteÃnas que pertencem a um grupo heterogÃneo de molÃculas com capacidade de ligaÃÃo especÃfica e reversÃvel a carboidratos. Desde sua descoberta, as lectinas se tornaram importantes ferramentas para a investigaÃÃo de fenÃmenos como a adesÃo, a migraÃÃo e a proliferaÃÃo celular, em condiÃÃes normais e patolÃgicas. Durante o processo de diferenciaÃÃo, cÃlulas tumorais apresentam vÃrios graus de modificaÃÃo na expressÃo de glicoproteÃnas de membra

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11

Bodily, Weston Reed. "Integrative Analysis to Evaluate Similarity Between BRCAness Tumors and BRCA Tumors." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6800.

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The term "BRCAness" is used to describe breast-cancer patients who lack a germline mutation in BRCA1 or BRCA2, yet who are believed to express characteristics similar to patients who do have a germline mutation in BRCA1 or BRCA2. Although it is hypothesized that BRCAness is related to deficiency in the homologous recombination repair (HRR) pathways, relatively little is understood about what drives BRCAness or what criteria should be used to assign patients to this category. We hypothesized that patients whose tumor carries a genomic or epigenomic aberration in BRCA1 or BRCA2 should be classif

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12

Neto, Daniel Messias de Moraes. "Predição do risco individual de micrometástase do tumor carcinóide típico broncopulmonar em função de variáveis clínicas, anatomopatológicas e biomarcadores teciduais." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-06052011-115608/.

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Introdução: Os tumores carcinóides broncopulmonares típicos são proliferações malignas neuroendócrinas. Até bem pouco tempo eram consideradas como adenomas, isto é, tumores benignos. Porém com o avanço dos estudos anatomopatológicos, foi identificada a sua face maligna, pois apresenta as principais características das neoplasias malignas, quais sejam: metástase e invasão tecidual local. Além das metástases, estes tumores são capazes de produzir outra entidade ainda pouco estudada e conhecida que é a micrometástase. Estas correspondem a metástases menores que 2mm de diâmetro, que podem ou não s

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13

Leruste, Amaury. "Immune context of malignant rhabdoid tumors : description and identification of new therapeutic targets." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS050.

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Les tumeurs rhabdoïdes (TR) constituent un rare cancer indifférencié du jeune enfant et du nourrisson, avec un âge médian au diagnostic de 20 mois. Ces tumeurs sont caractérisées par une inactivation biallélique du gène suppresseur de tumeur SMARCB1, un des membres du complexe SWI/SNF, acteur majeur du remodelage de la chromatine, sans autre altération génomique récurrente. Le pronostic des TR est péjoratif, le taux de survie globale atteignant 30% dans la plupart des séries, malgré des approches thérapeutiques conventionnelles particulièrement agressives. Les approches d’immunothérapies ont o

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14

Krogh, Karin. "Isolamento e caracterização de genes diferencialmente expressos em insulinomas benigos humanos." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-16022007-122349/.

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Os insulinomas são os mais comuns neoplasmas endócrinos pancreáticos, constituindo cerca de 17% de todos os tumores neuroendócrinos do trato digestivo. São tumores raros, que tem, como principal manifestação clínica, a hipoglicemia, a qual é ocasionada por secreção exagerada de insulina pelo tumor. Devido ao fato de serem tumores raros, o conhecimento das mudanças genéticas associadas à iniciação e progressão desses tumores é muito limitado. Em função disto, o objetivo deste trabalho é a identificação de genes diferencialmente expressos em insulinomas benignos humanos, visando o melhor ente

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15

Barazeghi, Elham. "Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors." Doctoral thesis, Uppsala universitet, Endokrinkirurgi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330810.

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Deregulation of the epigenome is associated with the initiation and progression of various types of human cancers. Here we investigated the level of 5-hydroxymethylcytosine (5hmC), expression and function of TET1 and TET2, and DNA methylation in parathyroid tumors and small intestinal neuroendocrine tumors (SI-NETs). In Paper I, an undetectable/very low level of 5hmC in parathyroid carcinomas (PCs) compared to parathyroid adenomas with positive staining, suggested that 5hmC may represent a novel biomarker for parathyroid malignancy. Immunohistochemistry revealed that increased tumor weight in

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16

Abrahão, Patricia Gemma Strappa. "Estudo retrospectivo de 3091 casos de neoplasias epiteliais primarias de glandulas salivares maiores e menores intra-orais." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288365.

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Orientador: Oslei Paes de Almeida<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-13T22:46:19Z (GMT). No. of bitstreams: 1 Abrahao_PatriciaGemmaStrappa_D.pdf: 7165544 bytes, checksum: 2315f68dcab46e1fc8757ecf3b27737f (MD5) Previous issue date: 2009<br>Resumo: O objetivo deste estudo foi analisar retrospectivamente as características histológicas e epidemiológicas de 3091 casos de neoplasias epiteliais primárias de glândulas salivares maiores e menores intra-orais do Brasil, México, Guatemala, Peru, Uruguai

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17

Rocha, Lilia Alves. "Estudo da expressão imunoistoquimica de KI-67, Mcm-2 e HOXB7 em neoplasias basaloides de cabeça e pescoço." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288419.

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Orientador: Pablo Augustin Vargas<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-15T10:55:45Z (GMT). No. of bitstreams: 1 Rocha_LiliaAlves_D.pdf: 2316332 bytes, checksum: 8ea247f73bbb3c563d66cdcf3dcabe9e (MD5) Previous issue date: 2010<br>Resumo: O presente trabalho avaliou a expressão dos marcadores de proliferação celular Ki-67, Mcm-2 e HOXB7 em neoplasias malignas epiteliais basalóides de cabeça e pescoço. Foram avaliadas 42 amostras tumorais da região de cabeça e pescoço, sendo 15 de carcinoma espinoc

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18

Zare, Fatemeh. "Tumors and Ly6Chigh Monocytes." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/291941.

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Cancer immunotherapy represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy – the current cornerstones of our fight against cancer. It has become clear now, that tumors not only escape immune recognition but also actively suppress antitumor immune responses. In order to improve cancer immunotherapy, effective manipulation of the immune system to break self-tolerance need to be designed and approaches that counteract immunosuppressive mechanisms need to be developed. The tumor microenvironment encompasses a wide variety of immune ce

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Padera, Timothy P. (Timothy Patrick) 1975. "Lymphatic pathophysiology of tumors." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29591.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2003.<br>Includes bibliographical references (leaves 146-166).<br>Lymph node metastases have a negative impact on cancer survival, but the mechanisms for lymphatic metastasis are not well understood. The universal finding in solid tumors of an absence of functional lymphatic vessels seems paradoxical, as cancer cells do travel through lymphatics in order to disseminate. In order to address some of these issues, this thesis proposes two etiologies for the absence of functional lymphatic vessels in solid tumors. The first h

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20

Siesjö, Peter. "Immunotherapy of rat brain tumors with mutagen induced, cross-reactive tumor cell variants." Lund : Section of Tumor Immunology, Dept. of Cell and Molecular Biology, University of Lund, 1997. http://books.google.com/books?id=TXZrAAAAMAAJ.

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Vanacker, Hélène. "Next generation sequencing of tumor samples : transversal approaches and characterization of rare tumors." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10371.

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Contexte : le séquençage de l’ADN ou ARN de tumeurs permet de les caractériser sur le plan moléculaire, mais si les données nombreuses et accessibles en sources ouvertes pour les principaux cancers, elles restent rares et difficiles d’accès dans les tumeurs rares dont les sarcomes. Les sarcomes à translocations de PATZ1, les synovialo-sarcomes, outre les données de séquencages de tumeurs fréquentes disponibles en sources ouvertes, du séquencage ARN (RNA-seq) sur prélèvements standards fixés en paraffine a été mis en place en routine au Centre Léon Bérard/Centre de Recherche en Cancérologie de

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22

Tan, Ern Yu. "Loss of protein folding gene expression in human tumors." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670106.

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De, Villiers Neil Heinrich. "Tumour metabolism and radioprotection of normal tissue in BALB/c and CBA mice." Thesis, Cape Technikon, 1992. http://hdl.handle.net/20.500.11838/1494.

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Thesis (Master Diploma (Medical Technology) -- Cape Technikon, Cape Town, 1992<br>The steady state in a tumour rapidly changes with its growth and the subsequent deteriorating blood and nutrient supply. This adaptation in the steady state of the tumour is shown in the increased lactate dehydrogenase and acid phosphatase activity in the tumour during it's growth. These alterations in the tumour metabolism places an increased burden on the body to supply nutrient and to discard the waste products of the tumour. This is demonstrated at the macroscopic level by the decreasing body weight and

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Martínez, Marisol Martínez 1982. "Estudo comparativo das características clínico-patológicas e imunohistoquímicas de tumores odontogênicos malignos e benignos = Comparative study of clinico-pathologic features of malignant and benign odontogenic tumors." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288357.

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Orientador: Oslei Paes de Almeida<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-26T10:32:36Z (GMT). No. of bitstreams: 1 Martinez_MarisolMartinez_D.pdf: 11593706 bytes, checksum: 9204e3ab03e2563ba5f0fa74b21ca2e2 (MD5) Previous issue date: 2014<br>Resumo: Os tumores odontogênicos (TO) são um grupo heterogêneo de lesões derivadas de tecidos dentários, que ocorrem nos ossos gnáticos e tecidos adjacentes. Os TO são raros, na grande maioria benignos, representando menos de 4% de todos os espécimes recebidos e

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Safdar, Shahana. "Peptide-targeted nitric oxide delivery for the treatment of glioblatoma multiforme." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45797.

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Glioblastoma multiforme (GBM) is the most common malignant central nervous system tumor. The ability of glioma cells to rapidly disperse and invade healthy brain tissue, coupled with their high resistance to chemotherapy and radiation have resulted in extremely poor prognoses among patients. In recent years, nitric oxide (NO) has been discovered to play a ubiquitous of role in human physiology and studies have shown that, at sufficient concentrations, NO is able to induce apoptosis as well as chemosensitization in tumor cells. This thesis discusses the synthesis and characterization of targete

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吳燕燕 and Yin-yin Go. "Quantitative structural studies of neoplasms of the parotid gland." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31212281.

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Chan, Chiu-lung Richie, and 陳肖龍. "Mucosal melanoma of the head and neck." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632876.

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Johansson, Soller Maria. "Cytogenetic studies of lung tumors." Lund : Dept. of Clinical Genetics, University of Lund, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39068855.html.

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Yun, Michael Jino. "Radiosurgery for Malignant Brain Tumors." VCU Scholars Compass, 1994. http://scholarscompass.vcu.edu/etd/5088.

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Radiosurgery using the Linear Accelerator or the Gamma Knife has proven to be an effective treatment modality for malignant brain tumors. In comparison to other treatments, radiosurgery can be performed on an outpatient basis and is noninvasive (Table 5). Due to the functional properties of radiosurgical devices, they are ideal for patients who are unable to undergo surgical removal of their brain tumors. The sharp dose drop—off beyond the tumor margin allows for high dosage tumor irradiation while sparing normal brain tissue. Many procedures that involve radiosurgery use it as a ”boost” thera

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Vamvakidou, Alexandra P. T̈ozeren Aydin. "Phenotypic heterogeneity of breast tumors /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1777.

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Einarsdóttir, Hildur. "Imaging of soft tissue tumors /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-647-2/.

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Kjellman, Magnus. "Genetic characterization of adrenocortical tumors /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3358-8/.

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Jandial, Rahul. "Lineage mapping of brain tumors." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3306998.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed June 30, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 125-137).

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Nguyen, Thi Trang Huyen. "How are pancreatic tumors innervated?" Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0536.

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L’adénocarcinome canalaire du pancréas (PDAC) est un des cancers les plus agressifs avec un taux de survie à 5 ans de moins de 5 %. Une des raisons est l’absence de traitement thérapeutique efficace. Des efforts afin d’identifier de nouvelles cibles pour le traitement du PDAC sont donc nécessaires. Il a été démontré que la dénervation du pancréas régule la progression des PDAC dans des modèles murins. De plus, on a rapporté que les axones du système nerveux périphérique (SNP) innervent les tumeurs pancréatiques, mais l'identité précise des fibres infiltrant la tumeur est inconnue.Ici, nous avo

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Zhu, Quan. "Role of CDP in MMTV transcriptional regulation and tumorigenesis." Access restricted to users with UT Austin EID, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037038.

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Taylor, Charles Dariush. "Structural characterisation and analysis of human cripto-1." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670042.

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Monteiro, Vasconcelos Ines [Verfasser]. "Epigenetic quantification of tumor-infiltrating T-lymphocytes in epithelial ovarian tumors / Ines Monteiro Vasconcelos." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052529828/34.

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Wang, Dian. "Mutational Inactivation of The P53 Tumor Suppressor Gene in Chemically-Induced Rat Esophageal Tumors /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487933245536557.

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Jin, Ling. "Study of tumorigenesis by means of transgenic mouse models expressing RET/PTC3 rearrangement and E7 under control of bovine thyroglobulin promoter and CD1 mouse strain treated with acrylamide." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210285.

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Thyroid carcinomas are the most common endocrine tumors in humans. There are three major types of carcinomas of thyrocyte origin, including papillary, follicular, and anaplastic carcinomas. Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy accounting 80% of thyroid cancer cases, and present several histologic variants, namely classical (45%), follicular (18%), solid, diffuse-sclerosing, cribriform, … .Specific genetic events represent early initiating and late triggering events. Several genetic lesions have been identified in various thyroid carcinomas and some of

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Cuellar, Baena Sandra Patricia. "Quantificação de sinais de MRS do cérebro in-vivo para classificação de tumores." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/277860.

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Orientador: Gabriela Castellano<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Fisica Gleb Wataghin.<br>Made available in DSpace on 2018-08-12T12:39:12Z (GMT). No. of bitstreams: 1 CuellarBaena_SandraPatricia_M.pdf: 2971806 bytes, checksum: 993051b37ed11a93fc4c48a83e24003d (MD5) Previous issue date: 2008<br>Resumo: Este trabalho visou o estudo e validação de técnicas de pre-processamento e quantificação de dados provenientes da técnica de Espectroscopia por Ressonância Magnética (MRS, do inglês Magnetic Resonance Spectroscopy), obtidos do cérebro humano in vivo,

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Pedro, Renato Nardi. "Uso da nanopartícula de ouro ligada a moléculas de fator alfa de necrose tumoral como adjuvante da termoablação por radiofrequência de tumores renais = modelo animal experimental." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310676.

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Orientadores: Marcelo Lopes de Lima, Nelson Rodrigues Netto Junior<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-17T00:02:35Z (GMT). No. of bitstreams: 1 Pedro_RenatoNardi_D.pdf: 3805668 bytes, checksum: 8b1ea901163cf75ede5f727e7f455e0c (MD5) Previous issue date: 2010<br>Resumo: O tratamento definitivo das massas renais malignas é primordialmente cirúrgico, sendo a nefrectomia radical eleita por muitos anos a cirurgia padrão para o tratamento do câncer renal localizado. Entretanto, com o envelhecimento populacion

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Capdevila, i. Castillón Jaume. "Tipificació molecular de tumors neuroendocrins gastroenteropancreàtics. Desenvolupament de noves teràpies i búsqueda de nous biomarcadors." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399562.

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El coneixement de la biologia molecular responsable de la carcinogènesi de les neoplàsies neuroendocrines segueix essent limitada avui en dia. Aquest fet, ha limitat la identificació de biomarcadors pronòstics i predictius i el desenvolupament de teràpies dirigies en aquesta població de pacients. L’objectiu de la present tesi doctoral ha estat identificar les alteracions genòmiques i epigenòmiques de neoplàsies neuroendocrines digestives i valorar la possibilitat de crear models murins derivats de pacients com a pas previ al disseny d’estudis clínics en pacients segons les alteracions molecula

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de, Villiers Neil Heinrich. "Tumour metabolism and radioprotection of normal tissue in Balb/c and CBA mice." Thesis, Cape Technikon, 1992. http://hdl.handle.net/20.500.11838/2253.

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Thesis (MTech (Medical Technology))--Cape Technikon, 1992.<br>The steady state in a tumour rapidly changes with its growth and the subsequent deteriorating blood and nutrient supply. This adaptation in the steady state of the tumour is shown in the increased lactate dehydrogenase and acid phosphatase activity in the tumour during it's growth. These alterations in the tumour metabolism places an increased burden on the body to supply nutrient and to discard the waste products of the tumour. This is demonstrated at the macroscopic level by the decreasing body weight and food intake when the

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Jimenez, Carolina Dias [UNESP]. "Relação entre os sinais clínicos neurológicos e os achados tomográficos de 20 cães com suspeita de neoplasia intracraniana." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/94577.

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Made available in DSpace on 2014-06-11T19:27:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-08-13Bitstream added on 2014-06-13T20:16:18Z : No. of bitstreams: 1 jimenez_cd_me_botfmvz.pdf: 2023223 bytes, checksum: 0d707644d193ee36e94427b90363ca22 (MD5)<br>Universidade Estadual Paulista (UNESP)<br>O intuito deste estudo foi determinar se os sinais neurológicos apresentados por cães com suspeita de neoplasia intracraniana foram compatíveis com a localização anatômica do tumor determinada com a utilização da tomografia computadorizada. Foram estudados 20 cães submetidos a avaliação neu

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Barreta, Amilcar 1980. "Laparoscopia na abordagem inicial de tumores anexiais = Laparoscopy for diagnosis and treatment of adnexal tumors." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312141.

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Orientadores: Sophie Françoise Mauricette Derchain, Joana Fróes Bragança Bastos<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-20T20:06:15Z (GMT). No. of bitstreams: 1 Barreta_Amilcar_M.pdf: 1818838 bytes, checksum: 256372229a80e175fc6ba44b44075f4f (MD5) Previous issue date: 2012<br>Resumo: Introdução: O câncer de ovário é o sétimo câncer mais comum em mulheres. A sensibilidade e especificidade dos exames laboratoriais e de imagem não são adequadas para o diagnóstico de câncer de ovário. Atualmente o padrão-

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Fonseca, Felipe Paiva 1986. "Semaphorins and neuropilins in salivary gland tumors : Semaforinas e neuropilinas em tumores de glândulas salivares." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288411.

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Orientador: Pablo Agustin Vargas<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-26T11:33:31Z (GMT). No. of bitstreams: 1 Fonseca_FelipePaiva_D.pdf: 1634857 bytes, checksum: 43da6be9627bec5197103495826aa6d6 (MD5) Previous issue date: 2015<br>Resumo: Tumores de glândulas salivares correspondem a aproximadamente 3% de todas as neoplasias de cabeça e pescoço e as neoplasias malignas derivadas destas estruturas anatômicas ainda representam um grande desafio para a oncologia de cabeça e pescoço devido a sua dif

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Machado, Lucas Faria Abrahão. "Pesquisa de biomarcadores como fator prognóstico nos tumores da família do sarcoma de Ewing." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5140/tde-10112017-115117/.

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INTRODUÇÃO: Os tumores da família do sarcoma de Ewing (TFSE) compreendem um espectro de neoplasias de células neuroectodérmicas dos ossos e partes moles de comportamento biológico agressivo e prognóstico reservado, caracterizadas por translocações envolvendo um dos genes da família TET/FET e um dos genes da família ETS, mais comumente EWSR1 e FLI1. Com o avanço da medicina personalizada, cresce a demanda por biomarcadores em TFSE que tenham valor como fatores prognósticos e potencial para futuras terapias-alvo específicas. Este estudo propôs biomarcadores, incluindo proteínas relacionadas à su

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Soldatelli, Jéssica Silveira. "Efeitos da combinação de temozolomida e ditelureto de difenila em linhagens celulares de glioblastoma." reponame:Repositório Institucional da UCS, 2018. https://repositorio.ucs.br/11338/4064.

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Os gliomas representam mais de 70% dos tumores cerebrais primários. Os glioblastomas multiformes são gliomas malignos caracterizados por baixa incidência, mas altas taxas de mortalidade. Apesar da responsividade inicial ao tratamento padrão realizado com o quimioterápico alquilante temozolomida (TMZ), poucos foram os avanços para o prognóstico dos pacientes nos últimos 10 anos. Isso deve-se ao fato desses tumores serem raramente passíveis de ressecção cirúrgica e apresentarem alta taxa de recorrência. Além disso, a eficácia de seu tratamento encontra barreiras como efeitos colaterais indesejáv

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Hartman, Caio Augusto 1977. "Ultrassonografia e CA-125 como preditores de malignidade em mulheres com tumores anexiais." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312140.

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Orientadores: Sophie Françoise Mauricette Derchain, Cássia Raquel Teatin Juliato<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T13:57:52Z (GMT). No. of bitstreams: 1 Hartman_CaioAugusto_M.pdf: 1648028 bytes, checksum: c76142fd3621c277879783c1e0cfdcb1 (MD5) Previous issue date: 2012<br>Resumo: Introdução: O câncer de ovário é a mais letal das neoplasias ginecológicas e representa a quinta causa mais comum de morte por câncer em mulheres. A sobrevida é baixa e não ultrapassa 40% após 5 anos e está diretamen

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Grochot, Rafael Maciel. "Expressão do PD-L1 em neoplasias cervicais e seu impacto em sobrevida associado à infiltração linfocitária peritumoral e à expressão de FOXP3." reponame:Repositório Institucional da UCS, 2018. https://repositorio.ucs.br/11338/3902.

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