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Artykuły w czasopismach na temat „Ulcer wounds”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Mosti, G. "Wound care in venous ulcers." Phlebology: The Journal of Venous Disease 28, no. 1_suppl (2013): 79–85. http://dx.doi.org/10.1177/0268355513477015.

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Wound dressings: ulcer dressings should create and maintain a moist environment on the ulcer surface. It has been shown that in an ulcer with a hard crust and desiccated bed, the healing process is significantly slowed and sometimes completely blocked so favouring infection, inflammation and pain. In contrast a moist environment promotes autolytic debridement, angiogenesis and the more rapid formation of granulation tissue, favours keratinocytes migration and accelerates healing of wounds. Apart from these common characteristics, wound dressings are completely different in other aspects and mu

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Henshaw, F. R., P. Boughton, L. Lo, S. V. McLennan, and S. M. Twigg. "Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing." Journal of Diabetes Research 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/236238.

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Aims/Hypothesis. Topical application of CTGF/CCN2 to rodent diabetic and control wounds was examined. In parallel research, correlation of CTGF wound fluid levels with healing rate in human diabetic foot ulcers was undertaken.Methods. Full thickness cutaneous wounds in diabetic and nondiabetic control rats were treated topically with 1 μg rhCTGF or vehicle alone, on 2 consecutive days. Wound healing rate was observed on day 14 and wound sites were examined for breaking strength and granulation tissue. In the human study across 32 subjects, serial CTGF regulation was analyzed longitudinally in

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Nather, Aziz, Siok Bee Chionh, Audrey YY Han, Pauline PL Chan, and Ajay Nambiar. "Effectiveness of Vacuum-assisted Closure (VAC) Therapy in the Healing of Chronic Diabetic Foot Ulcers." Annals of the Academy of Medicine, Singapore 39, no. 5 (2010): 353–58. http://dx.doi.org/10.47102/annals-acadmedsg.v39n5p353.

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Introduction: This is the first prospective study done locally to determine the effectiveness of vacuum-assisted closure (VAC) therapy in the healing of chronic diabetic foot ulcers. Materials and Methods: An electronic vacuum pump was used to apply controlled negative pressure evenly across the wound surface. Changes in wound dimension, presence of wound granulation and infection status of diabetic foot ulcers in 11 consecutive patients with diabetes were followed over the course of VAC therapy. Results: Healing was achieved in all wounds. Nine wounds were closed by split-skin grafting and 2

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Luo, Yun, Chen-Ying Li, Yu-Qing Wang, Sheng-Min Xiang, and Cheng Zhao. "Diabetic ulcer with cutaneous squamous cell carcinoma: A case report." World Journal of Clinical Oncology 15, no. 12 (2024): 1514–19. http://dx.doi.org/10.5306/wjco.v15.i12.1514.

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BACKGROUND Chronic skin ulcers are a risk factor for the development of skin tumors. In patients with diabetes, chronic refractory ulcers may also contribute to higher susceptibility to skin tumors. Timely surgical removal of chronic and nonhealing diabetic foot ulcers can effectively prevent progression to squamous cell carcinoma. Such cases may be misdiagnosed owing to currently insufficient clinical evidence. However, in cases of chronic ulcer wounds, it is crucial to enhance clinical awareness regarding their potential progression into malignant lesions. CASE SUMMARY An 84-year-old male pa

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5

Schmidt, Debus, Jeßberger, Ziegler, and Thiede. "Keimbesiedlung von chronischen Ulcera cruris: Unterscheidet sich das diabetische vom venösen und arteriellen Geschwür?" Vasa 29, no. 1 (2000): 62–70. http://dx.doi.org/10.1024/0301-1526.29.1.62.

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Background: At the Surgical Department of Surgery of the University Hospital Würzburg microbiological examinations were performed of the ulcer grounds from patients with diabetic-neuropathic, diabetic-ischemic, venous, and arterial leg ulcers. The aim of the examination was to evaluate possible differences in the healing process of these ulcers based on the knowledge of their bacterial populations. Patients and methods: In a period of four months, 63 patients were consecutively examined by taking a bacteriological swab of their ulcer area. The healing process of their wounds was followed and r

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Mrudul Mohan, Devan R, Anjitha ES, Archana IC, and Pavithra. "Ayurvedic management of Venous Ulcer - Case study." Journal of Ayurveda and Integrated Medical Sciences 9, no. 3 (2024): 222–26. http://dx.doi.org/10.21760/jaims.9.3.35.

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Varicose ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the legs. They are the major chronic wounds, occurring in 70% to 90% of leg ulcer cases. In Sushrut Samhita, where get the most scientific description of wound and its management. Similarly, Sushrut has given the almost importance to bloodletting therapy in Siravikara and Twakdosha. Aforesaid description let us to try Siravyadha. ln venous ulcer followed by dressing with Gomutraarka and Jathyadikeram. This treatment proved very effective and the ulcer healed completely within 30 days.

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Lu, Xuya, Qiang Xu, Pinchuan Li, and Zhaohui Zhang. "Therapeutic Effect of a Traditional Chinese Medicine on the Treatment of Painful Leg Ulcer." International Journal of Lower Extremity Wounds 19, no. 1 (2019): 89–98. http://dx.doi.org/10.1177/1534734619873786.

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This study aimed to investigate the therapeutic effect of a traditional Chinese medicine on the treatment of painful leg ulcer. Twelve cases of painful leg ulcer were recruited and their characteristics (etiology, size, Visual Analog Scale score, and duration) were recorded. Then, an herbal medicine–oriented treatment protocol combining Zhi Tong Sheng Ji powder (ZTSJ) and SJXP (Sheng Ji Xiang Pi plaster) was applied to these patients. The results suggested that this therapeutic protocol contributed to pain relief and promoted wound healing simultaneously. Specifically, 2 days after applying ZT

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Naziyah, Naziyah, Mohammed Saifulaman, Faridah Faridah, and Eliance Marpaung. "Effectiveness of polyhexamethylene biguanide (PHMB) against odor in diabetic foot ulcer." Malahayati International Journal of Nursing and Health Science 7, no. 5 (2024): 598–604. http://dx.doi.org/10.33024/minh.v7i5.314.

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Background: Diabetic foot ulcer are open wounds on the surface of the skin due to complications of macroangiopathy which causes vascular insufficiency and neuropathy. Odor found in diabetic foot ulcer or wound exudate can indicate the growth of microorganisms in the wound. Efforts that can be made to reduce infections that cause odor in wounds are by carrying out wound care starting at the initial stage of washing the wound. Wound washing using polyhexamethyl biguanide can reduce the odor of diabetic foot ulcer. Purpose: To determine the effectiveness of polyhexamethylene biguanide against odo

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9

Rogers, Burnett, Lindholm, et al. "Expression der Gewebe- und Plasminogen-Aktivator-Aktivitäten bei chronischen venösen Ulzera." Vasa 28, no. 2 (1999): 101–5. http://dx.doi.org/10.1024/0301-1526.28.2.101.

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Background: Chronic wounds have been shown to exhibit elevated levels of several classes of proteinases. Plasminogen activators (PAs) are proteinases which play a major role in the biological processes involved in wound healing and abnormalities in PAs may play a role in the pathology associated with chronic wounds. Here, we investigated the expression of tPA and uPA activities in chronic venous ulcer biopsies. Patients and methods: In 22 patients with chronic venous leg ulcers, punch biopsies were taken from the ulcer base, ulcer margin and uninvolved skin from the thigh of the affected limb

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Lestari, Desi, Indah Puspitasari, and Sunirah Sunirah. "Literature Review: Efektifitas Metode Moist Wound Healing pada Ulkus Diabetik." Jurnal Surya Medika 8, no. 3 (2022): 108–14. http://dx.doi.org/10.33084/jsm.v8i3.3161.

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One of the complications of diabetes mellitus is the presence of ulcer wounds which cause 50% to 75% of amputation. This literature review aims to determine the effectiveness of the Moist Wound Healing method in diabetic wounds. The design of this scientific paper is a literature review search using an electronic database, namely google scholar, semantic scholar, and pubmed. The keywords used in the search were: diabetes mellitus AND moist AND diabetic ulcer. Based on a literature review of 4 articles, significant results were obtained in wound healing, namely 2-3 times faster healing. it can

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11

Naef, Reto, Hermann Tenor, and Guido Koch. "TOP-N53: A Clinical Drug Candidate for the Treatment of Non-healing Wounds." CHIMIA International Journal for Chemistry 74, no. 10 (2020): 814–17. http://dx.doi.org/10.2533/chimia.2020.814.

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Chronic non-healing wounds impose a huge burden on patients and health care providers. In spite of improvements in standards of care there are no effective and safe treatments that promote new tissue formation and wound closure in ailments such as diabetic foot ulcer, pressure ulcer, venous leg ulcer or digital ulcer in systemic sclerosis. Endothelial dysfunction, which associates with impaired endogenous nitric oxide formation is assumed to be a main disease mechanism in chronic, non-healing wounds in diabetic and elderly patients as well as in digital ulcers in systemic sclerosis. Topadur Ph

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12

Stacey, Michael C., and Sandy D. Mata. "Lower Levels of PAI-2 May Contribute to Impaired Healing in Venous Ulcers — A Preliminary Study." Cardiovascular Surgery 8, no. 5 (2000): 381–85. http://dx.doi.org/10.1177/096721090000800510.

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Plasminogen activators may potentially influence the wound healing processes of cell migration matrix degradation and cellular adhesion in venous ulcers by their regulation of protease activity The aim of this study was to assess the levels of plasminogen activators in venous ulcers and to gain preliminary data from healing wounds. The concentrations of u-PA, t-PA, PAI-1 and PAI-2 antigen as well as functional u-PA were assessed in tissue homogenates from 20 chronic venous ulcers, six actively healing venous ulcers and five traumatic wounds. The concentrations of functional u-PA. u-PA antigen

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13

Alfarizi, Rizki, Renni Yuniati, Farmaditya Eka Putra Mundhofir, Noor Wijayahadi та Yora Nindita. "Correlation between TGF-β Levels and Degree of Wound Healing in Leprosy Ulcer Patients: An Observational Study at dr. Rehatta Regional Hospital Jepara". Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) 13, № 3 (2024): 158–61. http://dx.doi.org/10.14710/dmj.v13i3.44999.

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Background: Ulcers are one form of chronic wounds as one form of complication experienced by leprosy sufferers. In the process of healing wounds such as ulcers, TGF-β has a broad role. Several studies have stated that in chronic wound conditions there is a decrease in TGF-β levels so that the wound is increasingly difficult to heal. This study aims to determine the relationship between TGF-β serum levels and the degree of ulcer wound healing. Methods: This study is an observational analysis study with a cross-sectional design and involved 33 leprosy ulcer patients undergoing treatment at the d

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14

F. Arnold, Jonathan, and Douglas M. Arm. "Processed microvascular tissue improves healing in a case series of challenging wounds." Journal of Clinical and Translational Research 10, no. 5 (2024): 307. https://doi.org/10.36922/jctr.24.00059.

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Background: Healthy microvasculature provides nutrient and oxygen delivery and removes waste metabolites critical for sustained tissue viability and function after wound healing. Processed microvascular tissue (PMVT), a novel allograft, aims to directly address the compromised microvasculature found in chronic and complex wounds.Aim: Building on a Level 1 randomized controlled trial demonstrating improved healing and lower extremity sensation with PMVT in neuropathic diabetic foot ulcers, along with a sub-study demonstrating increased wound area blood flow, this article details the authors&amp

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Dudhamal, T. S. "Wound healing activity of Arjuna bark powder in Dushta vrana (Non healing venous ulcers) - A Case Report." Journal of Ayurvedic and Herbal Medicine 2, no. 4 (2016): 102–3. http://dx.doi.org/10.31254/jahm.2016.2402.

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A non-healing ulcer or chronic wound is defined as a wound that does not improve after four weeks or does not heal in eight weeks. These wounds include diabetic foot ulcers, venous-related ulcerations (varicose ulcers), pressure ulcers etc. Venous ulcers develop at medial part of lower leg and above the medial malleoli of foot and occur as a result of recanalization of DVT (deep vein thrombosis). These ulcers are often large in size, non-healing, tender and recurrent with secondary infection. In this case report a 65 years old male patient of non-healing multiple ulcers at left lower leg visit

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Sriwiyati, Lilik, and Budi Kristanto. "Karakteristik Luka Dan Penggunaan Balutan Luka Modern." Adi Husada Nursing Journal 6, no. 1 (2020): 8. http://dx.doi.org/10.37036/ahnj.v6i1.161.

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Abstract The most frequent injuries are chronic wounds, where the number is increasing every year. The most common type of wound is diabetic ulcer and the next is cancerous wound. Each wound has different characteristics, so the treatment of each wound is also different. There are various dressings in modern wound care, where each bandage has different indications according to the characteristics of the wound, it is necessary to do research on the characteristics of the wound and the use of modern wound dressing. The purpose of the study To describe the characteristics of wounds and the

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Nabila, Nadya Putri. "PROSES PENYEMBUHAN LUKA ULKUS DIABETIKUM DENGAN METODE MODERN DRESSING DIKLINIK MAITIS EFRANS WOUND CARE." JURNAL MEDIA KESEHATAN 10, no. 2 (2018): 146–51. http://dx.doi.org/10.33088/jmk.v10i2.336.

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Diabetes mellitus (DM) is one of the most common chronic diseases experienced by the world population and ranks fourth cause of death in developing countries. Long-term complications of diabetes mellitus one of them is diabetic ulcer (15%) and is the most cause (85%) of amputation in patients with diabetes mellitus. Currently, more than 5,000 modern types of dressings are reported to be available to treat wounds, especially diabetic ulcers. To know the process of wound healing diabetic ulcer was done with the design of case study research with a sample of 2 people and this study was conducted

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Niemiec, Stephen M., Amanda E. Louiselle, Kenneth W. Liechty, and Carlos Zgheib. "Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment." International Journal of Molecular Sciences 22, no. 1 (2020): 64. http://dx.doi.org/10.3390/ijms22010064.

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Pressure ulcers are preventable, yet highly prevalent, chronic wounds that have significant patient morbidity and high healthcare costs. Like other chronic wounds, they are characterized by impaired wound healing due to dysregulated immune processes. This review will highlight key biochemical pathways in the pathogenesis of pressure injury and how this signaling leads to impaired wound healing. This review is the first to comprehensively describe the current literature on microRNA (miRNA, miR) regulation of pressure ulcer pathophysiology.

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A. Yahia, Ehsan, Ayman E. El Sharkawey, and Magda M. Bayoumi. "Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Composite Nanosilver (AgNPs) - Based Dressing Vs. Traditional Dressing: A Prospective Randomized Control Study." Pakistan Journal of Medical and Health Sciences 15, no. 6 (2021): 2043–47. http://dx.doi.org/10.53350/pjmhs211562043.

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Background: The wound dressings perform a crucial role in cutaneous wounds management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Aim: the aim was to evaluate the effectiveness of using hydrogel/nano silver-based dressing vs. traditional dressing on diabetic foot wound healing. Methods: Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments. A prospective randomized control study was carried, and the results showed that the percentage of a reduction rate of the ulcer b

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Apriani, Rinda, Debie Dahlia, and Dikha Ayu Kurnia. "Penggunaan Negative Pressure Wound Therapy (NPWT) terhadap Diabetic Foot Ulcer." Journal of Telenursing (JOTING) 5, no. 1 (2023): 1040–49. http://dx.doi.org/10.31539/joting.v5i1.6184.

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This study aims to conduct a literature review related to research results that discusses the effectiveness of NPWT on diabetic foot ulcers (DFU). The method used is a systematic review method from online databases such as Scopus, ClinicalKey, ClinicalKey Nursing, EBSCOhost, Proquest, ScienceDirect, Springer Link, Pubmed, and SAGE Journals using the keywords diabetes mellitus, negative pressure wound therapy, NPWT, and diabetic foot ulcer. The search uses the "AND" and "OR" logic booleans. The results of a systematic review study obtained six articles describing showing that NPWT can help spee

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Kayiran, Mehmet Ergun, Ali Cımbız, Uğur Sözlü, and Özlem Altındağ. "Investigation of the effectiveness of dry needle therapy in pressure ulcers." Journal of Orthopedics Research and Rehabilitation 2, no. 3 (2024): 45–48. http://dx.doi.org/10.51271/jorr-0032.

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Aims: This study aims to show whether dry needle therapy is effective in the treatment of pressure ulcers in patients who have developed ulcers anywhere on their body for any reason. Methods: Thirty individuals (16 females, 14 males) with pressure ulcer were included in the study and a total of 6 sessions of dry needle therapy were applied to each individual with a one-day break. Before and after the application, circumference-diameter measurements of the wounds and staging according to the National Pressure Ulcer Advisory Panel scale were made and recorded with photographs. Results: While the

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Tamir, Eran, Timothy R. Daniels, Aharon Finestone, and Matityahu Nof. "Off-Loading of Hindfoot and Midfoot Neuropathic Ulcers Using a Fiberglass Cast with a Metal Stirrup." Foot & Ankle International 28, no. 10 (2007): 1048–52. http://dx.doi.org/10.3113/fai.2007.1048.

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Background: This study was designed to assess the effectiveness of a method of off-loading large neuropathic ulcers of the hindfoot and midfoot. The device used is composed of a fiberglass cast with a metal stirrup and a window around the ulcer. Methods: A retrospective study of 14 diabetic and nondiabetic patients was performed. All had chronic plantar hindfoot or midfoot neuropathic ulcers that failed to heal with conventional treatment methods. A fiberglass total contact cast with a metal stirrup was applied. A window was made over the ulcer to allow daily ulcer care. Results: The average d

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Forkuo-Minka, Anthony Octo, Augustine Kumah, and Afua Yeboaa Asomaning. "Improving Patient Safety: Learning from Reported Hospital-Acquired Pressure Ulcers." Global Journal on Quality and Safety in Healthcare 7, no. 1 (2024): 15–21. http://dx.doi.org/10.36401/jqsh-23-25.

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ABSTRACT Introduction A hospital-acquired pressure ulcer (HAPU) is a localized lesion or injury to the underlying tissue (wound) while the patient is on admission. It occurs when standardized nursing care is not correctly followed in the presence of friction and shear, leading to skin or underlying tissue breakdown. Unfortunately, inadequate knowledge of nurses to assess and provide standardized care for pressure ulcers or manage HAPUs results in patient harm. We aim to share lessons from a reported HAPU incident and address the knowledge gap in patient safety risk assessment, identification,

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Zhao, Liling, Zi Guo, Ke Chen, et al. "Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing." Stem Cells International 2020 (September 9, 2020): 1–13. http://dx.doi.org/10.1155/2020/8863649.

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Background. This study is aimed at investigating the effect of combined transplantation of umbilical cord mesenchymal stem cells (UCMSCs) and umbilical cord blood-derived endothelial colony-forming cells (ECFCs) on diabetic foot ulcer healing and at providing a novel therapy for chronic diabetic foot ulcer. Methods. We reported the treatment of refractory diabetic foot ulcers in twelve patients. Among them, five patients had two or more wounds; thus, one wound in the same patient was treated with cell injection, and other wounds were regarded as self-controls. The remaining seven patients had

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Tiwari, Kaushal K., Krishna G. Shrestha, Bijay Sah, and D. Jaypal Reddy. "Treatment of Chronic Venous Ulcers Using New Four Layers Compressive Bandage Dressing." Journal of Nepal Medical Association 53, no. 199 (2015): 156–61. http://dx.doi.org/10.31729/jnma.2782.

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Introduction: Lower-extremity ulcers represent the largest group of ulcers presenting to an outpatient department. It is a cumbersome, difficult to treat disease, which causes high morbidity and huge cost for the patient and healthcare system. Current standard treatment includes compression therapy. However, majority of patients need long term treatment with minimal efficacy. Aim of our study is to evaluate efficacy of four layers compressive bandages for the management of chronic venous ulcers. Methods: In Group A, we have prospectively included 20 patients with chronic venous ulcers on

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Satti, Memuna Kausar, Sadaf Humayun, Muhammad Sajid, Kunza Naveed Asdaq, Tehreem Ashraf, and Mahjabeen Aftab. "Hydrogels for Wound Dressing Applications - A Systematic Review." Pakistan Journal of Medical and Health Sciences 17, no. 3 (2023): 2–6. http://dx.doi.org/10.53350/pjmhs20231732.

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Aim: To discuss the currently available hydrogel wound dressings and their clinical effectiveness. Method: PubMed/Medline, HEC Digital Library, Wiley Online Library, Wolter Kluwer, Elsevier, and Google Scholar from the year 2013 to 2021 were searched to identify relevant clinical trials and studies. Results: Forty-three studies that assessed hydrogel vs. non-hydrogel dressings were identified. Compared to the latter, hydrogel dressings associated with a significantly shortened healing time of degree II burn (superficial and deep) wounds, diabetic foot ulcers, traumatic skin injuries, radioacti

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Javed, Muhammad Aslam, Sadaf Amin, Wishal Raza, and Imran Yousuf. "Efficacy and Safety of Intralesional Platelet Rich Plasma (PRP) Therapy in the Management of Chronic Non-healing Leg Ulcers in our Population." Pakistan Journal of Medical and Health Sciences 15, no. 10 (2021): 2746–48. http://dx.doi.org/10.53350/pjmhs2115102746.

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Background: Autologous Platelets Rich Plasma (PRP) therapy not only hastens chronic wounds and ulcers healing but also diminishes the rate of amputations of lower leg caused by non-healing recalcitrant ulcers. In this study we have demonstrated the magical results of intralesional autologous PRP in the healing of resistant to heal chronic leg ulcers. Methods: In this metacentric study 26 patients having 30 chronic leg ulcers of more than 6 weeks duration and various etiologies, were treated with intralesional autologous PRP application on weekly basis for a duration of 8 weeks and the final re

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Herron, Karena. "Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds." Journal of Wound Care 31, no. 11 (2022): 962–68. http://dx.doi.org/10.12968/jowc.2022.31.11.962.

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Objective: Complex hard-to-heal wounds are difficult to manage, generating significant expense to the US healthcare system, costing nearly $25 billion annually. Recently, a resorbable synthetic nanofibre matrix was trialled on a variety of complex hard-to-heal wounds at Astria Sunnyside Hospital to assess clinical efficacy. Method: In this case series, five patients with multiple comorbidities presented in both the inpatient and outpatient setting with various hard-to-heal refractory wounds, including a venous leg ulcer (n=1), a diabetic foot ulcer (n=1), a Charcot foot deformity (n=1) and pre

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Asutkar, Sheetal, Yogesh Yadav, and Harshad Prajapati. "Innovative Healing: Managing an Infected Non-Healing Chronic Ulcer with Panchvalkal Ointment." International Research Journal of Multidisciplinary Scope 05, no. 04 (2024): 1386–94. http://dx.doi.org/10.47857/irjms.2024.v05i04.01479.

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A wound that has not started to heal within 4 weeks, or not healed in 8 weeks is called a chronic, non-healing ulcer. Wounds such as varicose ulcers, diabetic foot ulceration, Pressure sores and other venous related lesions. These ulcers are frequently large, slow and non-healing painful erosions that come back time to time with signs of superimposed infection. Case history- A 50-year-old male presented to complaining of inflamed, painful and ulcerated lesion on the dorsum aspect on his left foot measuring 10 cm x 7 cm being present for nearly three months. His complaint was discharge and swel

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Madasu, Anvesh, Darshana Tote, and Lamture Yashwant. "Efficiency of Cadexomer Iodine in Healing of Chronic Leg Ulcer in View of Size and Volume." Journal of Evolution of Medical and Dental Sciences 11, no. 4 (2022): 508–12. http://dx.doi.org/10.14260/jemds/2022/102.

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BACKGROUND An ulcer is a break in the skin or mucous membrane with loss of surface tissue, disintegration and necrosis of epithelial tissue, and often infection. Chronic ulcers are ulcers present for more than 6 weeks and do not show the tendency of normal healing and require intervention for the healing process. There are several studies regarding wound treatment with topical applications and dressings that evaluate change in the bacterial bioburden and healing of the wound. In this study, we wanted to emphasize the in-vivo effect of cadexomer iodine antibacterial dressing on chronic non-heal

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Cavazzana, Rosanna, Angelo Faccia, Aurora Cavallaro, et al. "Enhancing Clinical Assessment of Skin Ulcers with Automated and Objective Convolutional Neural Network-Based Segmentation and 3D Analysis." Applied Sciences 15, no. 2 (2025): 833. https://doi.org/10.3390/app15020833.

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Skin ulcers are open wounds on the skin characterized by the loss of epidermal tissue. Skin ulcers can be acute or chronic, with chronic ulcers persisting for over six weeks and often being difficult to heal. Treating chronic wounds involves periodic visual inspections to control infection and maintain moisture balance, with edge and size analysis used to track wound evolution. This condition mostly affects individuals over 65 years old and is often associated with chronic conditions such as diabetes, vascular issues, heart diseases, and obesity. Early detection, assessment, and treatment are

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Salama, Shimaa Elhossieny, Ali Eid Eldeeb, Ahmed Husseiny Elbarbary, and Salwa Elmorsy Abdelghany. "Adjuvant Hyperbaric Oxygen Therapy Enhances Healing of Nonischemic Diabetic Foot Ulcers Compared With Standard Wound Care Alone." International Journal of Lower Extremity Wounds 18, no. 1 (2019): 75–80. http://dx.doi.org/10.1177/1534734619829939.

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Recent systematic reviews and meta-analyses have produced conflicting results about the efficacy of hyperbaric oxygen therapy (HBOT) in improving the healing rate for chronic diabetic foot wounds. This study aimed to assess the efficacy of systemic HBOT in healing of chronic nonischemic diabetic foot ulcer. Thirty adult patients having Wagner’s grade 2 or 3 chronic diabetic foot ulcers, in whom the response to 30 days of standard wound care was not favorable, were prospectively randomized to have either HBOT (20-40 sessions) plus conventional treatment (n = 15) or conventional treatment alone

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(Corresponding author), Suriadi, Rhamdaniyati, Wuriani Sudirjo, et al. "Case report on the use of a honey on diabetic foot ulcer patients." International Journal of Indonesian National Nurses Association (IJINNA) 1, no. 1 (2018): 98–104. http://dx.doi.org/10.32944/ijinna.v1i1.23.

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This article describes four infected diabetic foot ulcer patients who were treated with honey dressing as fragmented therapy. Quantitative and qualitative descriptions of the ulcer-healing process were documented. All four ulcers showed positive wound contraction and reduction in size, and clinical signs of infection were absent at the end of the follow-up period. Moreover, surrounding skin maceration and trauma were absent in all wounds. Adequate moisture control was also achieved, evidenced by a healthy red granulating base and a thin layer of clear light exudate in all fours cases. These re

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Ilham, Salsabila Nabilla Puspa, Indah Lestari, and Ida Maryati. "Use of Silver Dressing on Diabetic Ulcers During Infection: Case Report." Indonesian Contemporary Nursing Journal (ICON Journal) 9, no. 1 (2024): 77–88. http://dx.doi.org/10.20956/icon.v9i1.35190.

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Aims: This study aimed to describe the results of applying silver dressing on diabetic ulcers during infection in patients with infected wounds on digiti one pedis dextra. Methods: This research uses a descriptive design, namely a case study with a nursing approach consisting of assessment, analysis of problem formulation, formulation of nursing diagnosis, intervention, implementation, evaluation, and nursing documentation. The subject of this case study is Mrs. A with diabetic ulcers on Digi 1 pedis extra with infection. Case management was carried out for three days on April 17-19, 2024. Dat

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Nurwulandari, Rosana, and Yunita Sari. "The role of low-level laser therapy as a complementary approach in promoting wound healing among patients with diabetic foot ulcers: A systematic review." Malahayati International Journal of Nursing and Health Science 8, no. 2 (2025): 180–90. https://doi.org/10.33024/minh.v8i2.835.

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Background: A common and complicated side effect of diabetes is diabetic foot ulcers (DFUs), which frequently lead to chronic wounds that are challenging to heal. Another technique that has gained interest is low-level laser therapy (LLLT), which speeds up the healing of diabetic foot ulcers. The purpose of this systematic review is to evaluate how well LLLT aids in the healing of diabetic foot ulcers that are chronic. Purpose: To assess the effects of low-level laser therapy on the healing of diabetic foot ulcers, particularly with regard to ulcer size reduction, pain relief, and overall woun

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Nascimento, Núbia da Silva do, Júlia Borges de Macedo, Lucia Helena Garrido, Airton Vicente Pereira, and Priscileila Colerato Ferrari. "Clinical evaluation of calendula-alginate hydrogel dressing in chronic wounds: case study." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 23, no. 6 (2025): e10154. https://doi.org/10.55905/oelv23n6-007.

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Chronic wounds, such as venous ulcers and diabetic foot, represent significant public health challenges, compromising the quality of life of patients due to chronic pain, reduced mobility, and social stigmatization while imposing high costs from prolonged treatment. This clinical trial aimed to evaluate an alginate hydrogel dressing with calendula extract to promote the healing of venous and diabetic ulcers and improve patients' quality of life. This case study included two patients: a male patient with a diabetic ulcer and a female patient with a venous ulcer in the lower limb. Conducted at t

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Anselmo, Derek S., Marc Karpo, Ebony Love, and Tracey Vlahovic. "Comparing the Efficacy of Viable Cryopreserved Placental Membrane for the Treatment of Wounds of Diverse Etiologies." Journal of the American Podiatric Medical Association 106, sp1 (2016): 12. http://dx.doi.org/10.7547/8750-7315-2016.1.anselmo.

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INTRODUCTION AND OBJECTIVES: The benefits of using amniotic tissue in skin regeneration are well documented. Today, cryopreservation technology allows for better availability and maintenance of mesenchymal stem cells. This is of particular interest in treating the diabetic foot ulcer as this population has fewer mesenchymal stem cells. The objective of this case series investigation was to compare the efficacy of cryopreserved human amniotic stem cells in treating foot wounds of different etiologies. We will present data and case photos for a diabetic foot ulcer, venous leg ulcer, arterial ank

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Bayu Brahmantia, Yuyun Solihatin, and Heri Budiawan. "Characteristics of Wound Assessment According to Meggit-Wagner and Pedis and Spiritual Response in Diabetic Ulcer Patients at RSUD Dr. Soekardjo Tasikmalaya City." INDOGENIUS 4, no. 1 (2025): 216–23. https://doi.org/10.56359/igj.v4i1.566.

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Background & Objective: Diabetic ulcer is one of the complications of diabetes mellitus. Assessment of diabetic ulcers is done as a basis for determining wound care and therapy. Meggit-Wagner and Pedis have the advantages of a simple, easy-to-remember system, based on the location and depth of ulceration. A good quality of life for ulcer patients is an optimal functional condition in terms of physical, psychological, environmental, social and spiritual aspects. Good spirituality and social can improve the health of diabetic ulcer patients. Method: The purpose of the study was to determine

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Bhaskar, N., and Mayuri A. Kamble. "Study of efficacy of hyperbaric oxygen therapy in chronic wounds in diabetic patients." International Journal of Research in Medical Sciences 13, no. 7 (2025): 2848–54. https://doi.org/10.18203/2320-6012.ijrms20252018.

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Background: Diabetic patients are prone to chronic wounds that are difficult to heal due to impaired blood flow, immune dysfunction, and prolonged hyperglycemia. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment for diabetic wounds. This study aimed to evaluate the efficacy of HBOT in treating chronic wounds in diabetic patients. Methods: A prospective observational study was conducted at Sassoon General Hospital, Pune, Maharashtra from July 2022 to March 2024. A total of 34 diabetic patients with chronic non-healing ulcers were consecutively recruited and randomize

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Yahia, Ehsan A., Ayman E. El-Sharkawey, and Magda M. Bayoumi. "Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Nanosilver Based Dressing Vs. Traditional Dressing: A Prospective Randomized Control Study." Pakistan Journal of Medical and Health Sciences 15, no. 6 (2021): 1571–74. http://dx.doi.org/10.53350/pjmhs211561571.

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Background: The wound dressings perform a crucial role in cutaneous wounds management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Aim:To evaluate the effectiveness of using hydrogel/nanosilver-based dressing vs. traditional dressing on diabetic foot wound healing. Methods:Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments. A prospective randomized control study was carried Results: The results showed that the percentage of a reduction rate of the ulcer by the third

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Papi, Massimo, and Claudia Papi. "Biologics in Microangiopathic Wounds." International Journal of Lower Extremity Wounds 17, no. 4 (2018): 205–13. http://dx.doi.org/10.1177/1534734618813767.

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In the last decades the possibility to diagnose a skin ulcer has greatly improved. We learnt that a consistent percentage of nonhealing ulcers may be caused by a microangiopathic disorder that has not been properly investigated and cured. Pathogenetically, we can distinguish 2 main groups: (1) ulcers due to inflammatory microangiopathy, mainly including cutaneous small and medium vessel vasculitis, pyoderma gangrenosum, and connective tissue diseases, and (2) ulcers due to occlusive microangiopathy. The group of microangiopathic occlusive ulcers is more heterogeneous and includes different dis

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Klein, Robert. "Using Negative Pressure Wound Therapy With Instillation and Dwell Time to Create a Path to Closure for Older Patients With Chronic Wounds: A Retrospective Case Series." Wound Management & Prevention 68, no. 2 (2022): 16–21. http://dx.doi.org/10.25270/wmp.2022.2.1621.

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BACKGROUND: Chronic podiatric wounds are common causes of morbidity and mortality in older patients. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been recommended in wounds with high levels of exudate, contaminated wounds, and wounds in which healing progression has stalled. PURPOSE: This retrospective case series describes the use of NPWTi-d to prepare 4 chronic wounds for closure in older patients with multiple comorbidities. METHODS: Patients (N = 4) ranged in age from 65 to 95 years and had wounds present for at least 90 days. Previous treatments included

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Manley, Sarah, and Aby Mitchell. "The impact of nutrition on pressure ulcer healing." British Journal of Nursing 31, no. 12 (2022): S26—S30. http://dx.doi.org/10.12968/bjon.2022.31.12.s26.

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Pressure ulcers are debilitating and often painful problem, particularly in people who are elderly, immobile and/or obese. It is estimated that more than 100 000 new pressure ulcers develop each year. These wounds are caused by friction and shear and are particularly prevalent in older people, where malnutrition can be a factor in their development. Nutrition plays a key role in pressure ulcer care because wounds need both macronutrients and micronutrients to heal. It is essential that nurses understand the role of nutrition in pressure ulcer management.

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Bhedi, Amul, Mithun Panchal, Hitesh Patel, and Arnab Sarkar. "A comparative study of collagenase ointment versus povidone-iodine dressing in non-healing ulcers." International Surgery Journal 4, no. 6 (2017): 1992. http://dx.doi.org/10.18203/2349-2902.isj20172398.

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Background: The aim of the study was to evaluate effect of collagenase ointment and povidone-iodine on non-healing ulcer in the form of duration of ulcer covered with red granulation tissue and total hospital stay.Methods: The Study was conducted on 80 patients admitted in Surgery Department, SSG Hospital and Medical College Baroda, Gujarat, India during November 2006 to October 2008. All ulcers due to trauma, chronic ulcer or infected ulcer following debridement and incision and drainage were included in this study. In group A were wounds dressed in collagenase ointment and in group B were wo

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Arlis, Arlis, Maita Sarah, and Desika Mutuah. "Pengaruh Pengolesan Aloe Vera terhadap Proses Perubahan Derajat Luka Dekubitus." Jurnal Abdi Kesehatan dan Kedokteran 4, no. 2 (2025): 58–77. https://doi.org/10.55018/jakk.v4i2.85.

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Pressure ulcers are a serious health issue commonly found in patients with prolonged bed rest, particularly stroke patients. These wounds pose a risk of infection, increase morbidity and mortality rates, and prolong hospitalization. One natural therapeutic alternative increasingly used is Aloe vera gel, known for its antioxidant, anti-inflammatory properties and ability to accelerate tissue regeneration. The aim of this community service project was to determine the effect of Aloe vera application on changes in the severity of pressure ulcers in hospitalized patients. This study employed a qua

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Masi, Gresty, Mario Esau Katuuk, and Monique Priscilla Fransiska Rotty. "EFEKTIVITAS AIR MINERAL SEBAGAI CAIRAN PENCUCI LUKA UNTUK PENYEMBUHAN LUKA KRONIS." JURNAL KEPERAWATAN 11, no. 1 (2023): 81–85. http://dx.doi.org/10.35790/jkp.v11i1.48467.

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Background: Chronic wounds occur as a result of a failure in the wound healing process and until now have become a health problem that requires proper management. Several types of chronic wounds include venous leg ulcers (VLU), pressure ulcers (PU), diabetic foot ulcers (DFU). The use of wound cleansing fluid is one of the factors that plays an important role in chronic wound healing. Wound cleansing aims to clean the wound from the remains of previous dressings and reduce the number of bacteria. Mineral water is a type of liquid that can be used for cleansing chronic wounds and is easy to gai

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Rubianti, Marissa Astari, Evy Ervianti, Muhammad Yulianto Listiawan, et al. "Efficacy of 5% Tea Tree Oil Hydrogel on Healing Morbus Hansen's Chronic Plantar Ulcer." Berkala Ilmu Kesehatan Kulit dan Kelamin 33, no. 1 (2021): 28. http://dx.doi.org/10.20473/bikk.v33.1.2021.28-33.

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Background: The damage of the peripheral nerves that occurs in Morbus Hansen (MH) patients can cause disability due to loss of sensory, motor and autonomic functions can cause wounds, infections, ulcers and disability. Ulcers are the most common cause of disability complications in MH patients and requires a certain time of healing. As many as 10-20% of MH patients experience ulcers on the soles. Tea Tree Oil (TTO) is extracted from steam distillation of the leaves and twigs of the Australian native shrub Melaleuca Alternifolia. In ulcers, TTO can work as an antimicrobial, anti-inflammatory, a

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Ju, Wendong, Gaoming Ding, Feng Ge, et al. "Treatment of hard-to-heal ulcerative wounds with manually separated allogeneic platelets mixed with cryoprecipitate: three case reports." Journal of Wound Care 34, no. 7 (2025): 488–95. https://doi.org/10.12968/jowc.2023.0203.

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Objective: To report the effectiveness of allogeneic manual platelet separation and cryoprecipitate gel on hard-to-heal (chronic) wound healing in patients of older age. Method: Three patients aged 70–72 years were selected for this study. Among them, one had hard-to-heal diabetic foot ulcers (DFUs), one had developed large pressure injuries on the gluteal area, and one suffered from a purulent ulcer of the lower extremity. After thorough debridement, one unit (U) of allogeneic artificial platelets and 1–1.5U of cryoprecipitate were used to make the gel preparation which was subsequently appli

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Sukmana, Mayusef, Roni Sianturi, and Muhammad Aminuddin. "Application of International Best Practice Guideline in Diabetic Ulcer Patients." Journal Of Nursing Practice 3, no. 1 (2019): 50–62. http://dx.doi.org/10.30994/jnp.v3i1.65.

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Background: Diabetic ulcer is one of the complications of Diabetes mellitus. Assessment of diabetic ulcers is done as a basis in determining wound care and therapy provided so that it needs to know its characteristics.Purpose: This study was to determine the characteristics of wounds assessment tools diabetic ulcer International Best Practice Guideline (IBPG).Method: The study design was descriptive with a case study approach, the sampling technique was purposive sampling carried out in May 2019 with three respondents. The instrument used is the wound assessment tool International Best Practic

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Mendonca, Derick A., Tom Cosker, and Nilesh K. Makwana. "Vacuum-Assisted Closure to Aid Wound Healing in Foot and Ankle Surgery." Foot & Ankle International 26, no. 9 (2005): 761–66. http://dx.doi.org/10.1177/107110070502600915.

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Background: Although vacuum-assisted closure (VAC) is a well-established technique in other surgical specialties, its use has not been established in the foot and ankle. The aims of this study were to determine if vacuum-assisted closure therapy (VAC) helps assist closure in diabetic foot ulcers and wounds secondary to peripheral vascular disease, if it helps debride wounds, and if it prevents the need for further surgery. Methods: We retrospectively reviewed 15 patients (18 wounds or ulcers) with primary diagnoses of diabetes (10 patients), chronic osteomyelitis (two patients), peripheral vas

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