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Rozprawy doktorskie na temat „Vaccination of infants Evaluation”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 28 stycznia 2023

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1

Boros, Christina Ann. "Factors affecting the immunogenicity and protective efficacy of routine childhood immunisations." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phb736.pdf.

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Includes list of publications arising from the thesis. Bibliography: leaves 327-341. Examines the effect of adverse storage on the immunogenicity of pertussis, diphtheria and tetanus vaccines, the protective efficacy of pertussis vaccines and the effect of premature birth on antibody response to routine childhood immunisations.

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2

Lu, Qiuying Sandy, and 呂秋瑩. "Health economic evaluation of universal infant hepatitis B vaccination programmes in China." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207183.

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Introduction: China has about 120 million hepatitis B virus (HBV) carriers and a 7.2% hepatitis B surface antigen (HBsAg) prevalence in 2006.This creates a huge disease burden and also leads to significant economic losses. Since 2002, a free universal infant hepatitis B vaccination programme has provideda 3-dose primary vaccination for all infants. Although some economic evaluations of this programme have been conducted, a comprehensive cost-effectiveness analysis (CEA) to estimate long-term benefit using mathematical modeling would aid understanding of population strategies for hepatitis B co

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3

Brisson, Marc. "Economic evaluation of vaccination programmes : a special reference to varicella vaccination." Thesis, City University London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407544.

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4

Dinan, Leonie Rita. "Antibody responses after Hib immunisation in premature and term infants /." Title page, table of contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09MPM/09mpmd583.pdf.

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5

Tchakoute, Christophe Toukam. "Effects of delayed BCG vaccination on cellular immune responses in HIV-exposed infants." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/6007.

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6

Vermeulen, Françoise. "Réponses immunitaires du grand prématuré à la vaccination contre la coqueluche." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209427.

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Les enfants nés prématurément, et plus particulièrement les grands prématurés nés avant<p>31 semaines d’âge gestationnel, sont à haut risque de contracter des infections. La<p>vaccination peut prévenir certaines infections, dont la coqueluche qui est causée par la<p>bactérie Bordetella pertussis (Bp). Cependant, cette maladie infectieuse hautement<p>contagieuse est en recrudescence depuis plusieurs années malgré une bonne couverture<p>vaccinale. La morbidité et surtout la mortalité de la coqueluche affectent plus<p>particulièrement les jeunes enfants, incomplètement ou non encore vaccinés.<p>I

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7

Njikan, Samuel Ayaba. "Correlates of risk of TB disease in infants with differential response to BCG vaccination." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/12873.

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Includes bibliographical references.<br>Studying prospective immune correlates of risk of TB disease following BCG vaccination is an important first step towards determining correlates of protection against TB, which can be identified only in a placebo-controlled randomized controlled trial (RCT) of an effective vaccine. To study correlates of risk of TB disease, we collected and stored blood from healthy 10-week old infants vaccinated with BCG at birth. During two years of follow up, infants who developed lung TB were defined as cases, while those who did not develop TB disease were defined a

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8

Alsalih, Dina A. "The Impact of Vaccination Schedules on Infants' and Children's Physio-Psychological Health: A Qualitative Investigation." ScholarWorks, 2014. https://scholarworks.waldenu.edu/dissertations/112.

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Many people may have become increasingly concerned about the risks associated with vaccines. At the same time, there is a lack of qualitative research on the impact of various vaccinations schedules on individuals' physio-psychological health. In addition, "mandatory" versus "nonmandatory, but recommended" vaccines are still under debate in some Western countries. The purpose of this ethnographic study was to provide an in-depth understanding of the beliefs, experiences, and perceptions of adolescents, parents, and health care providers regarding different vaccination schedules. The health bel

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9

DUTOT, PHILIPPE. "Evaluation des lactobacilles comme vecteurs vivants de vaccination." Université Louis Pasteur (Strasbourg) (1971-2008), 1996. http://www.theses.fr/1996STR13232.

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Dans le cadre du developpement de nouveaux vecteurs vivants de vaccination administrables par voie mucosale, le potentiel de bacteries commensales du genre lactobacillus a ete etudie. Ceci impliquait d'aborder les domaines suivants: microbiologie (choix de la souche vaccinale), biologie moleculaire (production d'antigenes heterologues) et immunologie (nature et intensite des reponses immunes induites). La souche lactobacillus paracasei lbtgs1. 4, isolee du vagin de souris, a ete selectionnee comme souche modele. Elle a ete utilisee pour mener des etudes de colonisation chez la souris: cette so

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10

Ortega, Omayra Y. "Evaluation of rotavirus models with coinfection and vaccination." Diss., University of Iowa, 2008. http://ir.uiowa.edu/etd/34.

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11

Peterson, Tia. "Evaluation of Vaccination Policies Among Utah Pediatric Clinic Employees." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5560.

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Introduction: Pediatric health care settings are high risk environments for spreading communicable and vaccine preventable diseases from health care workers to susceptible patients. Methods: All managers of pediatric clinics operating in the state of Utah were included. Participants were invited to complete a two-page questionnaire regarding their clinic vaccination policies. Results: Half (n = 23, 50%) of Utah pediatric outpatient clinics recommend employee vaccinations, although employee refusal is allowed without consequence. Of all adult vaccines, influenza was most often included as p

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12

Sullivan, Janet E. "Hearing Evaluation in Infants: An Update for Pediatricians." Scholar Commons, 2003. https://scholarcommons.usf.edu/etd/1487.

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This paper provides an overview of developmental timetables relevant to hearing and of current pediatric audiological techniques and practices. The first sections summarize structural and functional development of the auditory pathway and the development of primary auditory processing. These developmental sequences appear to follow similar paths in humans and animals. Speech and music perception involve more complex processing and are strongly influenced by experience. Hearing disorders affect the perception of complex sounds in a variety of ways, depending on the site(s) of lesions. Early ons

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13

PELLAT, COIGNET BRIGITTE. "La coqueluche dans les bouches-du-rhone : evaluation de la couverture vaccinale." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20191.

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14

Arenas, Gamboa Angela Maria. "Evaluation of microencapsulation as an improved vaccination strategy against brucellosis." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1384.

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15

Knight-Jones, Theo. "Field evaluation of foot-and-mouth disease vaccination in Turkey." Thesis, Royal Veterinary College (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618321.

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16

Le, Louarn Anne. "Evaluation du programme national de vaccination dans le département de la Gironde." Bordeaux 2, 1994. http://www.theses.fr/1994BOR23075.

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17

Prentice, Philippa. "The evaluation of blood and breast milk biomarkers relating to patterns of infancy growth and nutrition." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709022.

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18

Dube, Frederick. "The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/10377.

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Includes bibliographical references (leaves 102-114).<br>Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are born preterm [PT (<37 weeks gestation)], or have low birth weights [LBW (<2,500g)], with >90% of these born in developing countries, where the majority of TB cases are found. It is not known how birth weight at the time of vaccination may affect the BCG-induced immune response and subsequent protect

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19

Luchsinger, Rebecca. "Creation and evaluation of an informational website about the influenza vaccination." The University of Arizona, 2011. http://hdl.handle.net/10150/623568.

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Class of 2011 Abstract<br>OBJECTIVES: The purpose of this study was to create and evaluate the usability and credibility of an informational website about the influenza vaccination. METHODS: This was a descriptive study of user’s reactions to a website. Questionnaires administered during a regularly scheduled class collected ratings of the usability and credibility of an informational website about the influenza vaccination; data on vaccination status, year in pharmacy school and plans for future vaccination were also collected. RESULTS: Questionnaires were completed by 8 students. Eighty-ei

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20

Kuruvilla, Denison John. "Evaluation of erythropoiesis in anemic low birth weight preterm infants." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1981.

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Anemia of prematurity is characterized by a progressive decline in hemoglobin level during the first month of life. Unlike term newborns, preterm infants become anemic and often require red blood cell transfusions. Various factors contribute to the development of this anemia. These include short infant red blood cell (RBC) lifespan, decline in erythropoiesis rate after birth, and blood losses caused by repeated phlebotomies. The objectives of this work were to develop novel models to evaluate fetal and

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21

Clark, Michael. "Benefits and risks of neonatal bacille Calmette-Guerin (BCG) vaccination among Aboriginal infants in Canada: Assessment by Markov model." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26461.

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Bacille Calmette-Guerin (BCG) vaccine is given to Canadian Aboriginal neonates in communities at high risk for tuberculosis (TB). However, severe reactions and deaths associated with the vaccine have been reported among infants born with immunodeficiency syndromes. A Markov model was developed to estimate the burden of TB among Canadian Aboriginal children, evaluate the effectiveness of BCG vaccination, and estimate threshold values for severe combined immunodeficiency (SCID) incidence at which a BCG program will reduce quality-adjusted life expectancy. Estimated thresholds for SCID are lower

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22

Nundalall, Trishana. "CD4 and CD8 T-cell responses to acellular pertussis and rotavirus vaccination in breast-fed HIV exposed, uninfected infants." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25382.

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Introduction: Vaccination is one of the most efficient ways to prevent infectious diseases, however due to the naivety and regulation of immunity found in infants, induction of vaccine-mediated immunity is challenging. Respiratory and diarrheal diseases are major contributors to infant mortality. Additionally, Human Immunodeficiency Virus-1 (HIV) infections increase the risk of mortality. Current advances in Prevention of Mother-to-Child Transmission (PMTCT) have prevented HIV infections in almost 97% of infants being born to HIV-infected mothers. As a result there is an increasing number of H

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23

Keyser, Alana. "BCG-specific T cell proliferation and cytotoxic capacity in infants as risk of tuberculosis disease, following newborn BCG vaccination." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/14085.

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Includes bibliographical references.<br>BCG is the only vaccine against tuberculosis and has been used for over 90 years. BCG efficacy is variable, especially in countries with high TB prevalence, where over a million deaths due to tuberculosis, are still reported annually. New TB vaccines are under development to either replace or boost the BCG vaccine. However, our understanding of the immune response required for protection against TB disease, remains inadequate. Identification of a protective immune response is only possible in a clinical trial of an efficacious vaccine, allowing compariso

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24

Chan, Susan Deborah. "Impact evaluation of a milk supplementation programme on weight of children 6-24 months of age in Guyana, South America." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0007/MQ44143.pdf.

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25

Jayaraj, Ramamoorthi, and Jayaraj@menzies edu au. "Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials." RMIT University. Applied Science, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20081029.100156.

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The liver flukes Fasciola hepatica and F. gigantica cause infectious disease in ruminants and humans. The geographical range of these two parasite species (temperate and tropical respectively) ensures that infection can occur worldwide. Although anthelmintic treatment is effective against disease, emerging drug resistant strains leads to the development of a vaccine. However, despite several decades of research, there is no commercial vaccine available. The main challenge at present is to produce recombinant proteins in an immunologically active form using recombinant DNA technology. This is a

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26

Selim, Mohamed E. "Tick-host interactions : evaluation of resistance, salivary gland antigens, and DNA vaccination /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488193272067399.

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27

Aquilano, Giulia <1979&gt. "Evaluation of immune function in preterm infants using Immuknow® assay." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7293/.

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Background. Neonatal immune system is not fully developed at birth; newborns have an adequate leukocytes and lymphocytes count at birth but these cells lack of function. Objective. To assess the functional activity of T-cells at birth and at 30 days of life and the influence of the main perinatal factors in a population of preterm infants. Design. A prospective longitudinal study was carried out in a population of 59 preterms. Fifteen healthy adults were included as a control group. Blood samples were collected at birth and at 30 days of life to evaluate CD4+ T cell activity using the Immukn

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28

Gonin, Patrick. "Evaluation de vecteurs recombinants adénovirus comme vaccins contre les virus de l'immunodéficience féline (FIV) et de la peritonite infectieuse féline (PIF)." Paris 11, 1995. http://www.theses.fr/1995PA114837.

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Song, Andrew M. Eng Massachusetts Institute of Technology. "Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45353.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2008.<br>Includes bibliographical references (leaves 66-69).<br>Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumor cells. Despite the amount of ongoing intensive research to prevent cancer, tumor cells continue to evade immune responses. Currently, dendritic cell vaccines are in development, in which autologous antigen-loaded dendritic cells are injected back into the patient in order to generate an appropriate immune response. Improving upon this idea, mem

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Stocksdale, Sarah Louise. "Evaluation of Vaccination Policies Among Outpatient Oncology Clinics in Utah: A Pilot Study." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5849.

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Background: In Utah, all major hospital facilities have employee vaccination policies. However, the presence of health care worker vaccination policies in the Utah outpatient oncology setting was unknown. Objectives: The objectives were to identify Utah oncology outpatient employee vaccination policies and to identify what consequences, if any, were present for unvaccinated employees. Methods: This was a cross-sectional, descriptive study design in which clinic managers from outpatient oncology clinics in Utah were asked, via questionnaire, to describe the clinic's employee vaccination policy

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31

Banks, Kristina L. "Process Evaluation of Group Well Child Visits for One-Month-Old Infants." Case Western Reserve University Doctor of Nursing Practice / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=casednp1460750207.

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Bodamer, Cheryl N. "Evaluation of an Early Discharge Policy For Infants With Apnea of Prematurity." VCU Scholars Compass, 2008. http://hdl.handle.net/10156/1698.

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33

Rajananthanan, Palasingam. "Evaluation of novel aggregate structure adjuvants to potentiate immune responses to soluble protein antigen." Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325240.

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34

Walters, Adam Alexander. "The development and evaluation of a nanoparticulate antigen delivery system for vaccination of cattle." Thesis, University of Surrey, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600038.

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Conventional subunit vaccine regimes can be modified in order to stimulate strong immune responses resulting in memory cell formation. An adjuvant system that has gained increased attention in recent years is the use of particulate antigen delivery. Particulate systems have a number of advantages over conventional approaches since they are believed to be taken up preferentially by dendritic cells (DC) where they prolong the release of antigen resulting in enhanced T cell stimulation. Furthermore, they offer a versatile system that allows for targeted delivery of antigen and adjuvant to the sam

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35

Bearchell, Melissa Clare. "Evaluation of tumour response to DNA vaccination using MRI : development of a model system." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621265.

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36

Thambiran, Mona. "Economic evaluation of a school based human papillomavirus (HPV) vaccination program in South Africa." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/46147.

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Introduction Oncogenic human papillomavirus (HPV) types 16 and 18 pose the greatest risk for cervical cancer. Infection with HPV types 16 and 18, which cause 70% of cervical cancer worldwide, could be prevented with commercially available HPV 16 and 18 vaccines. A previous study in South Africa demonstrated that vaccination of 12 year old girls with a HPV vaccine, prior to sexual debut, is cost effective, however this was carried out prior to the roll-out of the HPV vaccination program. The aim of this study is to provide an up-dated cost effectiveness analysis of HPV 16 and 18 vaccination of

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37

Chong, Siu-yung, and 莊少容. "Evaluation of Apgar score as an intermediate assessment of the risk ofearly mortality." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30273195.

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38

Yuan, Siyang. "Socially excluded mothers and infants : an evaluation of community based health promotion programmes." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486264.

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The aim of this thesis was to evaluate two community based health promotion programmes for Irishborn (NI) and Chinese immigrant mothers and infants living in deprived areas. Study 1: A cross-sectional study to compare differences in NI and Chinese immigrant mothers' dental health and mother and infant's weight status. Mothers' oral health and health related knowledge, attitudes and behaviours regarding oral health, infant feeding, childhood obesity and mother-infant bonding were compared. The findings suggested that Chinese compared with NI mothers had poorer oral health and health related kno

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39

Tan, Enda. "Infants’ performance on sociomoral evaluation tasks predicts parent report of preschool social functioning." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54293.

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The present study examined developmental continuity in social functioning from infancy to preschool. Specifically, we examined the relationships between infants’ performance on sociomoral evaluation studies and parent report of their preschool social functioning. Infants’ performance, emotional stability (fuss-out rate), and average habituation rate in moral evaluation tasks were collected. Preschool social functioning was measured through parent-report online scales. The results showed 1) that better performance on infant moral evaluation studies was associated with lower rates of parent repo

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40

Jackson, Elizabeth Anne. "A critical evaluation of respiratory function testing in spontaneously breathing and ventilated infants." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299878.

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41

Nguyen, Amy, Sarah Deitering, Hanna Phan, Megan Brandon, and Kathryn Matthias. "Evaluation of Treatment and Outcomes in Infants and Children with Urinary Tract Infection." The University of Arizona, 2015. http://hdl.handle.net/10150/614007.

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Class of 2015 Abstract<br>Objectives: In 2011, the American Academy of Pediatrics released an updated urinary tract infection guideline that addressed diagnosis, antibiotic treatment, and duration of therapy in children ages 2-24 months. The objectives of this study were to evaluate the appropriateness of antibiotic prescribing and compare outcomes between age groups. Methods: This retrospective chart review included patients aged 1 month through 12 years admitted to a regional academic medical center from January through July 2014 and diagnosed with UTI or pyelonephritis. Patients were iden

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42

Best, Emma Women's &amp Children's Health Faculty of Medicine UNSW. "Once daily gentamicin in infants and children: an evaluation of safety and the role of therapeutic drug monitoring in minimising toxicity." Awarded by:University of New South Wales, 2007. http://handle.unsw.edu.au/1959.4/35192.

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AIMS: To assess (i) the safety of once daily dosing (ODD) of gentamicin by systematic evaluation of ototoxicity and nephrotoxicity; and (ii) the usefulness of therapeutic drug monitoring (TDM) in a paediatric cohort. METHOD: Infants and children with suspected or proven gram negative sepsis were enrolled prospectively to receive ODD gentamicin at 7 mg/kg/day. Neonates were excluded. Hearing and renal function were assessed at baseline, during and after therapy by otoacoustic emissions (OAE) and by either serum creatinine or glomerular filtration rate. Abnormal OAE were followed with audiometry

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43

Biswal, Jitendra Kumar. "Evaluation of mucosal immunity in FMDV vaccinated and infected cattle." Thesis, Royal Veterinary College (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572448.

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44

Byers, Stacey Renee. "Bovine viral diarrhea virus : evaluation of persistent infections, acute transmission, and vaccination protection in alpacas." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Spring2009/s_byers_041509.pdf.

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Thesis (M.A. in veterinary science)--Washington State University, May 2009.<br>Title from PDF title page (viewed on Apr. 23, 2010). "Department of Veterinary Clinical Sciences." Includes bibliographical references (p. 83-89).

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45

Harding, Scott V. "Evaluation of the iron, antioxidant and dietary status of iron supplemented breastfed healthy infants /." Internet access available to MUN users only, 2003. http://collections.mun.ca/u?/theses,160317.

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46

Neelotpol, Sharmind. "Evaluation of lead in meconium : a study on UK infants of South Asian origin." Thesis, University of Leeds, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634214.

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Human exposure to lead, a persistent inorganic metal, can pose a significant risk to health and can arise from several sources e.g. lead-based paint, soil, dust, water pipes, and traditional cosmetics/remedies. A principal concern of lead exposure is for the foetus because without noticeable symptoms in the child lead can lower IQ, Standard Assessment Test (SATs) scores, and may increase the involvement in crime. The aim of this study was to evaluate lead exposure in South Asian infants. The hypothesis was that, living in the same environment, the South Asian 'mother-foetus unit' is more expos

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47

Skillern, Laurence Howard. "Evaluation of the fetal electrocardiogram in the detection of myocardial ischaemia in preterm infants." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243594.

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Salem, Hanaa A. "Design and evaluation of a hepatitis B immunization program for pharmacy students." Scholarly Commons, 1992. https://scholarlycommons.pacific.edu/uop_etds/2226.

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The objectives of this study are: (1) To compare the effectiveness of two dosing schedules of hepatitis B vaccine in achieving compliance within the vaccines; (2) To determine the immunization requirements in U.S. pharmacy schools both at admission and before the students begin clinical clerkships; and, (3) To design an immunization program for pharmacy students at the University of the Pacific in an attempt to enhance compliance.

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49

Rivera, Jocelyn Renee, and Jocelyn Renee Rivera. "Development and Evaluation of a Clinical Practice Guideline to Promote an Evidence-based Approach to Vaccine Hesitancy in Primary Care." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/626638.

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The purpose of this project is to develop a clinical practice guideline with recommendations for vaccination and vaccine hesitancy in the pediatric setting. Routine vaccinations are given to children at recommended ages to decrease the incidence of, and prevent infectious disease. These vaccinations prevent diseases such as rotavirus, diphtheria, pertussis, tetanus, hepatitis B, haemophilus influenza type B, pneumococcal disease, polio, influenza, measles, mumps, rubella, varicella and hepatitis A. There are currently no guidelines that combine evidence-based interventions to increase vaccinat

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Ashok, M. S. "Evaluation Of The Efficacy Of DNA Vaccines For Japanese Encephalitis In A Murine Intracerebral Japanese Encephalitis Virus Challenge Model." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/169.

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Japanese encephalitis virus (JEV), a member of the family flaviviridae, is one of the most important pathogens of the developing countries, causing high mortality and morbidity amongst children. The present study is aimed at the development of a DNA vaccine for Japanese Encephalitis (JE). As a first step towards developing a DNA vaccine for JE, an eukaryotic expression plasmid encoding the envelope (E) glycoprotein of Japanese Encephalitis Virus (pCMXENV) was constructed. This plasmid expresses the E protein intracellularly, when transfected into Vero cells in culture. Several independent immu

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