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Rozprawy doktorskie na temat „VDR polymorphism”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Egan, Jan Bailey. "Evaluating the Role of VDR Polymorphisms and Beta-catenin Signaling in Colorectal Neoplasia." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195709.

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Colorectal cancer is estimated to cause approximately 50,000 deaths each year in the United States. Epidemiological studies have demonstrated an inverse association between sunlight exposure, which stimulates the formation of vitamin D in the skin, and colorectal carcinoma. Laboratory studies report that metabolites of vitamin D, acting through the vitamin D receptor (VDR), regulate cellular proliferation, differentiation and apoptosis. In addition, VDR contains a polymorphic variant, FokI, which results in two different isoforms of VDR. We have demonstrated a differential suppression of β-cat

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Обухова, Ольга Анатоліївна, Ольга Анатольевна Обухова, and Olha Anatoliivna Obukhova. "Association TaqI polymorphism of VDR gene in smokers and non-smokers, among patients with ischemic stroke." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/41244.

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Obinna, N. K., and T. Mutanikwa. "Impact of VDR gene polymorphism on the development of ischemic stroke in smokers and non-smokers." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/60775.

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Today, we have ample evidence that hormonal system of vitamin D, the main component of which is calcitriol (1α,25(OH)2D3) and receptor of vitamin D (VDR) plays an important role not only in the regulation of functional and metabolic processes in the body, but also in the development of many diseases, including cardiovascular disease. The risk factors for ischemic stroke can be divided into unregulated (age, gender, race) and susceptible (malnutrition, lack of physical activity, smoking, alcohol abuse). Smoking doubles the risk of stroke. Once you stop smoking, the risk of a stroke in you will

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Обухова, Ольга Анатоліївна, Ольга Анатольевна Обухова, Olha Anatoliivna Obukhova, L. A. Kolo, and M. A. Chibueze. "Association ApaI polymorphism of VDR gene with the development of ischemic stroke in individuals of different sex." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/60782.

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In the overwhelming majority of cases, cerebral stroke is a multifactor disease, in the development of which, along with other factors, an undoubted role is played by changes in the system of hemostasis. In the last decade considerable attention has been paid to the study of the influence of genetic predisposition on the hemostatic system. In general, the risk of stroke in men is 30% higher than that of women. However, this is typical only for the age group of the population from 45 to 64 years. At the age of more than 65 years, the risk of stroke in men and women is practically the same.

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Обухова, Ольга Анатоліївна, Ольга Анатольевна Обухова, Olha Anatoliivna Obukhova та ін. "Оцінка зв'язку BsmI поліморфізму гена VDR з антропометричними показниками у хворих з ішемічним інсультом". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45046.

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Актуальність. Інсульт є однією з основних причин смерті в розвинених країнах і тим більше в Україні. Поширеність інсульту і тягар інвалідності, як очікується, зростуть в майбутньому, оскільки відбувається процес старіння населення. Крім віку до чинників ризику розвитку інсульту відносяться артеріальна гіпертензія, паління, цукровий діабет, гіпертрофія лівого шлуночка і фібриляція передсердь. Ожиріння, як правило, передує розвитку артеріальної гіпертензії, цукрового діабету та їх ускладнень, що грає важливу непряму роль в епідеміології ішемічного інсульту. Метою нашої роботи було провести анал

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Bueno, Larissa Souza Mario. "Vitamina D, polimorfismos do gene VDR e neurofibromatose 1." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/52955.

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Introdução: A Neurofibromatose tipo 1 (NF1) é uma doença genética autossômica dominante causada por mutação no gene NF1 (17q11.2; proteína neurofibromina). A incidência é de aproximadamente 1:3500 recém-nascidos e o diagnóstico clínico é possível na maioria dos casos. Alguns estudos sugeriram que pacientes com NF1 são mais suscetíveis a apresentar deficiência de vitamina D quando comparados à população geral. Objetivo: Determinar os níveis de 25(OH)D em indivíduos com NF1 e em controles saudáveis. Nos pacientes com NF1 nos também avaliamos o fenótipo clínico e analisamos polimorfismos comuns d

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Issa, Chahira Taha Mah D. Ibrahim. "Relação entre perfil cardiometabólico, status de vitamina d e polimorfismo bsmi do gene vdr em idosos." Universidade Federal da Paraíba, 2014. http://tede.biblioteca.ufpb.br:8080/handle/tede/4307.

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Made available in DSpace on 2015-04-17T15:03:04Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2451134 bytes, checksum: cd1a58c82bfe6936ed40ff974a4a3740 (MD5) Previous issue date: 2014-03-13<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The high prevalence of hypovitaminosis D in the elderly population is identified as a potential risk factor for the development of cardiovascular diseases. The vitamin D receptor (VDR) is present in various body cells and polymorphisms of the gene encoding it can affect the cell responses to vitamin D. Therefore, this study aimed t

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Обухова, Ольга Анатоліївна, Ольга Анатольевна Обухова, Olha Anatoliivna Obukhova та ін. "Зв'язок Aраl поліморфізму гена VDR з ішемічним інсультом з урахуванням дисліпопротеїнемії атерогенного характеру". Thesis, Івано-Франківський національний медичний університет, 2019. https://essuir.sumdu.edu.ua/handle/123456789/80864.

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У розвитку атеросклерозу вагоме значення належить запальним процесам у судинній стінці. Враховуючи імуномоделюючі властивості вітаміну D, його вплив на регуляцію атеросклеротичного процесу може мати важливе значення у розвитку серцево-судинних захворювань, включаючи клапанні кальцифікації, гіпертонію, ішемічний атеротромботичний інсульт.

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Ferrarezi, Daniela Andraus de Figueiredo. "Variações alélicas no gene do receptor da vitamina D (VDR) e risco de doença arterial coronariana em pacientes diabéticos tipo 2." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-05052011-142938/.

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A doença cardiovascular (DCV) é a principal causa de mortalidade e morbidade em pacientes portadores de diabetes mellitus tipo 2 (DM 2), estando associada com mais de 80% das mortes nesses pacientes. Portadores de DM 2 têm um risco três vezes maior em relação à indivíduos não diabéticos de desenvolver aterosclerose e suas complicações clínicas como infarto agudo do miocárdio (IAM), acidente vascular cerebral (AVC) e doença vascular periférica. O sistema endócrino da vitamina D regula a diferenciação e a proliferação de vários tipos celulares, além de possuir propriedades antiinflamatórias e an

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Обухова, Ольга Анатоліївна, Ольга Анатольевна Обухова, Olha Anatoliivna Obukhova, and K. M. Sheikh. "Variants polymorphisms of genes vitamin D receptor (VDR)." Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27511.

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Xavier, David André Rodrigues. "Vitamin D receptor (VDR) gene polymorphisms and genetic susceptibility to thyroid cancer." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1630.

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Thyroid cancer is the most common endocrine malignancy and a complex disease with a largely unknown aetiology. Thyroid carcinomas are derived from thyroid follicular cells and parafollicular cells. The majority of thyroid cancer cases comprise both papillary (PTC) and follicular carcinomas (FTC). The evaluation of genetic susceptibility could give valuable information regarding the risk of thyroid cancer development. There are many genes associated with the thyroid function that modulates the risk of tumour development. Among them, is the vitamin D receptor gene (VDR), located on chromosome 12

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Обухова, Ольга Анатоліївна, Ольга Анатольевна Обухова, and Olha Anatoliivna Obukhova. "The association between the VDR polymorphisms and cardiovascular diseases." Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27494.

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The vitamin D receptor (VDR), through the binding of 1,25 vitamin D and subsequently modulating the transcription of target genes, mediates the vitamin D endocrine system. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/27494

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Jain, Reema. "When too much sun is never enough: Association of the VDR gene polymorphisms with insulin resistance." AUT University, 2010. http://hdl.handle.net/10292/990.

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The metabolism of vitamin D commences with exposure of the skin to sunlight. The growing recognition of its role in insulin resistance, autoimmune disorders, infections, cancer, as well as the health of cells that influence physical and mental function have profound implications on how we define vitamin D requirements and why we should care whether they are met or not. Most of the actions of vitamin D are mediated by the vitamin D receptor (VDR), a protein whose gene sequence can vary, giving rise to polymorphic forms which are potent enough to affect the binding capacity of this protein to vi

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Van, Pelt Chad. "The Interaction of β-catenin, Vitamin D, Resveratrol, and Two Common VDR Polymorphic Variants in Colorectal Carcinogenesis". Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/606228.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Vitamin D and resveratrol have been widely researched in recent years, especially their apparent abilities to impact a host of physiological processes. Resveratrol, a phytoalexin found in various berries, peanuts, and other vegetables, is purported to possess anti-aging, anti-inflammatory, antioxidant, anticancer, neuroprotective, and antiarthritic properties, while the classical endocrine functions of vitamin D are the control of cal

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Kameoka, Shinichiro. "Flower color polymorphism in Hepatica nobilis var. japonica with reference to genetic backgrounds and reproductive success." Kyoto University, 2019. http://hdl.handle.net/2433/242752.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第21875号<br>人博第904号<br>新制||人||215(附属図書館)<br>2018||人博||904(吉田南総合図書館)<br>京都大学大学院人間・環境学研究科相関環境学専攻<br>(主査)教授瀬戸口浩彰, 教授加藤眞, 教授市岡孝朗, 准教授西川完途<br>学位規則第4条第1項該当

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Semianiv, M. M. "Hormonal and metabolic risk factors of essential arterial hypertension depending on polymorphic variants of the AGTR1 (rs5186) and VDR (rs2228570) genes." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19580.

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Santos, Betânia Rodrigues dos. "Estudo da associação entre polimorfismos do gene do receptor de vitamina D (VDR) e do SNP-71 A/G do gene 17 beta- hidroxiesteróide desidrogenase tipo 5 (HSD17B5) e variáveis clínicas, hormonais e metabólicas em pacientes com pubarca precoce e controles." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/31696.

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A pubarca precoce (PP) é definida como o desenvolvimento de pêlos pubianos antes dos 8 anos de idade em meninas e 9 anos de idade em meninos. Embora a PP não interfira diretamente com os eventos da puberdade, algumas evidências sugerem que estas meninas tenham maior risco para desenvolver, mais tarde, a Síndrome dos Ovários Policísticos (PCOS). A 17ß-hidroxiesteróide desidrogenase tipo 5 (17ßHSD5) é a principal responsável pela conversão de androstenediona em testosterona. Variações no gene que codifica para essa enzima, em especial os polimorfismos de nucleotídeo único (SNPs), podem estar rel

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Bokelmann, Kristin [Verfasser], Mladen [Akademischer Betreuer] Tzvetkov, Hans-Joachim [Akademischer Betreuer] Fritz, and Jürgen [Akademischer Betreuer] Brockmöller. "Charakterisierung des 5-HT3B-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus / Kristin Bokelmann. Gutachter: Hans-Joachim Fritz ; Jürgen Brockmöller. Betreuer: Mladen Tzvetkov." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1042669856/34.

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Landomiel, Flavie. "Propriétés signalétiques des B-arrestines : mise en évidence de nouveaux partenaires et implications fonctionnelles." Thesis, Tours, 2015. http://www.theses.fr/2015TOUR4044.

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Les β-arrestines jouent un rôle important dans la transduction du signal par les récepteurs couplés aux protéines G (RCPG). Nous montrons dans cette thèse que les β-arrestines exercent des régulations plus complexes et subtiles qu'on ne le pensait jusque-là sur la voie AMPc/PKA/CREB qui est activée par les RCPGs couplés à Gs. Nous montrons que les β-arrestines interagissent directement la PKAcat et contribuent à sa translocation nucléaire. De plus, nous mettons en évidence une interaction β-arrestine/CREB qui conduit à la formation d'un complexe transcriptionnellement actif sous l’action de l’

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Souza, Cleber Machado de. "Análise da associação entre polimorfismos no gene do receptor da vitamina D (VDR) e a suscetibilidade à doença renal crônica e à doença periodontal = Association between vitamin d receptor gene polymorphisms and susceptibility to chronic kidney disease and periodontitis / Cleber Machado de Souza ; orientadora, Paula Cristina Trevilatto ; co-orientador, Roberto Pecoits-Filho." reponame:Biblioteca Digital de Teses e Dissertações da PUC_PR, 2007. http://www.biblioteca.pucpr.br/tede/tde_busca/arquivo.php?codArquivo=1256.

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Tese (doutorado) - Pontifícia Universidade Católica do Paraná, Curitiba, 2007<br>Inclui bibliografias<br>A doença renal crônica (DRC) e a doença periodontal (DP) são sérios problemas de saúde-pública, sendo esta última especialmente negligenciada na população de renais crônicos. A vitamina D é um hormônio esteróide solúvel, metabolizado no fígado e nos rins,<br>Chronic kidney disease (CKD) and periodontitis (PD) are serious public-health concerns, but the latter has been especially neglected in the CKD population. Vitamin D is a fat-soluble steroid hormone, metabolized in the liver and then in

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Ko, Chen-Chung. "Lead in umbilical cord blood, VDR-FokI polymorphism and children's neurodevelopment at the age of two years." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-0511200715522700.

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Ko, Chen-Chung, and 柯晨鍾. "Lead in umbilical cord blood, VDR-FokI polymorphism and children’s neurodevelopment at the age of two years." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/95418873179836069215.

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碩士<br>臺灣大學<br>職業醫學與工業衛生研究所<br>96<br>Lead may produce adverse effects on the nervous system and influence cognition, memory and intelligence. Even with low dose exposure, lead may still have adverse effects on humans, especially infants and pregnant women. Genetic polymorphism may play an important role in modulating the health effects, but there have been few studies about the relation between genetic polymorphism and infant neurobehavioral development. The objective of this study was to explore the modifier effect of VDR FokI polymorphism on lead exposure and early childhood neurodevelopment.

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GIOVINAZZO, SALVATORE. "Vitamin D receptor gene polymorphisms/haplotypes and serum 25(OH)D3 levels in Hashimoto's thyroiditis." Doctoral thesis, 2017. http://hdl.handle.net/11570/3105461.

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Vitamin D deficiency and/or reduced function, as per certain polymorphisms of the vitamin D receptor (VDR) gene, have been related to several autoimmune disorders. The present study was aimed to investigate the association of Hashimoto's thyroiditis with vitamin D status and functional polymorphisms (SNPs) of the VDR gene. In this case-control study, 200 euthyroid subjects were enrolled: 100 newly diagnosed HT patients (87 F, 13 M; mean age ± SD 42 ± 15 year) and 100 healthy individuals, matched for age, sex, BMI, and month of blood sampling. Serum 25(OH)D3 was measured by HPLC. The VDR SNPs B

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"Vitamin D receptor (VDR) polymorphisms: effect on VDR levels and cell proliferation in EBV transformed B-lymphocytes." Thesis, 2008. http://hdl.handle.net/10210/392.

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The vitamin D receptor (VDR) is a transcription factor mediating genomic responses to the biologically active form of vitamin D, 1,25(OH)2D3, a key modulator of the immune system. Knowledge on how these polymorphisms modulate the vitamin D endocrine system and confer risk of disease is hindered by the fact that several of the associated allelic variants are located in introns or are synonymous and likely serve as markers within an extended haplotype covering disease-causing alleles. The functional relevance of VDR polymorphisms need to be studied in the context of the haplotype, comparing hapl

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"Polymorphisms in the regulatory region of the Vitamin D Receptor gene (VDR): in silico analysis, tuberculosis association and functional impact." Thesis, 2011. http://hdl.handle.net/10210/3712.

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M.Sc.<br>Tuberculosis, of which the causative agent is Mycobacterium tuberculosis, presents itself as a serious health problem globally, especially in Africa. Susceptibility to this infectious disease is influenced by the virulence of the strain of mycobacteria, environmental factors, and genetic variation within the host. The Vitamin D Receptor gene or VDR has been identified as a candidate gene for TB susceptibility. This gene codes for the VDR protein that mediates the biological actions of the active form of vitamin D. Vitamin D has been shown to impair growth of Mycobacterium tuberculosis

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Gardiner, Courtney Elizabeth Campbell. "Colours of confetti: the role of ABP genes and environmental variables in flower colour polymorphisms of Rhodohypoxis baurii var. confecta." Thesis, 2019. https://hdl.handle.net/10539/29470.

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A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa in fulfilment of the requirements for the degree of Master of Science, 2019<br>The study of flower colour is a particularly valuable approach to investigating fundamental evolutionary questions such as the maintenance of variation within species, the role of natural selection and genetic drift in maintaining polymorphisms, and how such polymorphisms contribute to biodiversity. Flower colour is a phenotype that is easily measured and it provides a strong indicator of the out

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Kuo-Pao, Liu, та 劉國保. "Study of Association of RAS and TGF-β1 Gene Polymorphisms with Primary VUR Development and Progression". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/90819119759609357797.

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碩士<br>國立臺灣師範大學<br>生物研究所<br>91<br>Vesicoureteral reflux (VUR) is a common pediatric disease that may lead to severe end-stage renal disease (ESRD) in part of patients. The development of VUR is highly familial inherited and the disease progression is variable. The renin-angiotensin system (RAS) and transforming growth factor-b1 (TGF-b1) involve in the development of urinary system and may also be the potential candidate prognostic factors in the progression of ESRD. In this study, the RAS related angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II type 1 receptor (AT1

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Shen, Zi Ru, and 沈姿如. "Stduy on the taxonomic identity of schima superba var. superba and S. superba var. kankaoensis by random amplified polymorphic DNA (RAPD)." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/27494675779896588354.

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碩士<br>國立中興大學<br>森林學研究所<br>84<br>Schima superba var. superba is an important native and plantation species in Taiwan and S. superba var. kankaoensis is a variety of S. superba var. superba. Since there is no reli-able morphological characteristic to distinguish the two of them, we tried to use a new technique, random amplified polymorphic DNA(RAPD), to study the taxonomic identity of the two species. Twenty arbitrary sequenced primers(10 nucleotides in length) were selected to proceed RAPD-PCR. One hundred and forty seven bands were recorded and 90(%) of them were polymorphic bands. DNA markers

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Chen, Yu-An, and 陳俞安. "Effect of metallothionein 2A (MT2A) and vitamin D receptor (VDR) genetic polymorphisms on blood lead and cadmium concentration among female immigrants in Southern Taiwan." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/01254956898274487088.

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碩士<br>中國醫藥大學<br>公共衛生學系碩士班<br>101<br>Background: The International Organization for Migration (IOM) has reported that there are approximately 215 million international migrants among nations at present, the number will reach 405 million by 2050. Several studies also showed that international immigrants are at a high risk of exposing to lead and cadmium. Importantly, the genetic variation of metallothionein 2A (MT2A) and vitamin D receptor (VDR) may moderate the metabolic ability for lead and cadmium in the human body. Methods: A cross-sectional study was performed to include 670 new immigrant f

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Burrell, Anna Mildred. "Molecular and Genetic Analysis of Adaptive Evolution in the Rare Serpentine Endemic, Caulanthus amplexicaulis var. barbarae (J. Howell) Munz." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8239.

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In the interest of understanding the genetic basis of adaption to environment, we developed F2 lines from an F1 interspecific cross between the rare serpentine endemic, Caulanthus amplexicaulis var. barbarae and the non-serpentine Caulanthus amplexicaulis var. amplexicaulis. Using genomic DNA from Caulanthus amplexicaulis var. barbarae, we developed a suite of microsatellite markers. In addition, we developed gene specific markers for genes known in Arabidopsis to be ecologically important. Our suite of markers was used to genotype 186 F2 plants, the basis for our F2 linkage map. In order to f

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Bokelmann, Kristin. "Charakterisierung des 5-HT_3B-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-AE42-E.

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Lai, Yi-Chun, and 賴怡君. "Association of KLK1, TIEG1/EGR alpha, TNF-alpha, IL-1 alpha and IL-1 beta Gene Polymorphisms with Primary VUR Development and Progression." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/98592337289531940449.

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碩士<br>國立臺灣師範大學<br>生命科學研究所<br>92<br>Vesicoureteral reflux (VUR) is a common pediatric disease. The development of VUR is highly familially inherited and the disease progression is variable. Some patients may lead to severe end-stage renal disease (ESRD). In this study, polymorphisms of human renal kallikrein gene (KLK1), TGFβ-inducible early gene 1/early growth response  gene (TIEG1/EGR), tumor necrosis factor- gene (TNF-), interleukin-1 gene (IL-1), interleukin-1 gene (IL-1) were evaluated for the association with VUR development and progression in Taiwanese children. The KLK1 promoter

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Taylor, Ian Wesley. "The relative contribution of vitamin D receptor (VDR), collagen type 1, α-1 (COL1A1), tumor necrosis factor receptor 2 (TNFR2), polymorphisms, physical activity and bone mineral-free lean mass to bone parameters in children". Thesis, 2002. http://hdl.handle.net/2429/13993.

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Background: This study sought to investigate the relationship of physical activity (PA), dietary calcium and 3 candidate gene (VDR, COL1A1 and TNFR2) genotypes on bone mass in children (n = 327, age 10.33 ± 0.65). The study also sought to investigate the effect of PA and genotype on bone mineral-free lean mass (BMFL). Finally, the relationships between bone mass and BMFL and PA, BMFL and genotype and PA and genotype interactions were investigated. Methods: Anthropometric data (height, sitting height and weight) was determined using standard techniques. Bone mass, and BMFL were assed using tota

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