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Artykuły w czasopismach na temat „Village alzheimer”

Autor: Grafiati

Data publikacji: 25 stycznia 2025

Data aktualizacji: 31 lipca 2025

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Planque-Bonini, Anne-Laure. "Le village landais Alzheimer, un concept innovant." Ortho Magazine 27, no. 154 (2021): 19–23. https://doi.org/10.1016/s1262-4586(21)00079-0.

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Lemaire, Alexandre, Stéphany Lemaître, Géraldine Camagne, Florent Ruzzu, and Virginie Jolly. "Résultats préliminaires sur l’occupation du Premier âge du Ferde Dax, Village Alzheimer (40)." Bulletin de l'Association Française pour l'Étude de l’Âge du Fer 37, no. 1 (2019): 15–18. https://doi.org/10.3406/afeaf.2019.1197.

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Ramadas, Chavakula, Reddy Karuru Mallikarjuna, Saladi J. S. Chakradhar, Gouri K. Vijaya, N. Annapurna, and Babu K. Raghu. "An improved and green synthesis of N-benzyl-4-formylpiperidine, a key intermediate of donepezil." Journal of Indian Chemical Society Vol. 95, Oct 2018 (2018): 1245–48. https://doi.org/10.5281/zenodo.5653511.

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Research and Development, Aurobindo Pharma Limited, Survey No: 71 & 72, Indrakaran Village, Sangareddy Mandal, Medak-502 329, Telangna, India E-mail: ramadas.chavakula@gmail.com Department of Engg. Chemistry, Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India <em>Manuscript received 08 June 2018, accepted 14 August 2018</em> An industrially viable and green synthesis of <em>N</em>-benzyl-4-formylpiperdine (<strong>2</strong>), a key intermediate of <em>Donepezil hydrochloride </em>(<strong>3</strong>) (Aricept<sup>®</sup>), a selective inhibitor of acetyl cholinesterase (A

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Lemaire, Alexandre, Marie-José Ancel, Nadine Béague, et al. "Une nécropole à crémation et un dépotoir du Premier âge du Fer à Dax (Landes), “Village Alzheimer, rue Pascal Lafitte”." Aquitania : une revue inter-régionale d'archéologie 36, no. 1 (2020): 51–71. http://dx.doi.org/10.3406/aquit.2020.1519.

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Pangandaheng, Nansy Delia, and Gitalia Putri Medea. "DETEKSI DINI INGATAN (MEMORI) PADA LANSIA DENGAN MENGGUNAKAN SHORT PORTABLE MENTAL STATUS QUESTIONNAIRE (SPMSQ) DI KAMPUNG BELENGAN KECAMATAN MANGANITU." Jurnal Ilmiah Tatengkorang 6, no. 1 (2022): 43–48. http://dx.doi.org/10.54484/tkrg.v6i1.444.

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Abstrak: Perkembangan memori pada lansia dapat mengalami kemunduran terutama dalam perkembangan kemampuan mental, termasuk kehilangan memori, disorientasi dan kebingungan. Penurunan fungsi kognitif yang terjadi pada lanjut usia dapat berlanjut menjadi gangguan demensia vaskuler maupun alzheimer disease apabila tidak ditangani dengan baik. Tujuan PKMS ini yaitu mengetahui fungsi kognitif pada lanjut usia. Kegiatan penyuluhan dilakukan dari rumah ke rumah hal ini dilakukan karena pandemi Covid-19, dimana tim pengabdian mengunjungi rumah-rumah lansia yang tinggal dikampung Belengan Kecamatan Mang

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Dainy, Nunung Cipta, Inne Indraaryani Suryaalamsah, and Dadang Herdiansyah. "SENAM OTAK SERTA EDUKASI KONSUMSI PANGAN SUMBER VITAMIN B12 DAN OMEGA-3 UNTUK CEGAH ALZHEIMERS." JMM (Jurnal Masyarakat Mandiri) 7, no. 2 (2023): 1138. http://dx.doi.org/10.31764/jmm.v7i2.13258.

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Abstrak: Lansia berisiko mengalami penurunan fungsi kognitif atau alzheimers yaitu ketika mengalami kesulitan mengingat, mempelajari hal-hal baru, berkonsentrasi, atau membuat keputusan yang memengaruhi kehidupan sehari-hari. Salah satu upaya mencegah terjadinya penurunan fungsi kognitif adalah dengan mengonsumsi pangan sumber vitamin B12, omega-3 dan aktivitas senam otak. Tujuan kegiatan ini adalah meningkatkan pengetahuan pralansia dan lansia tentang upaya pencegahan penyakit alzheimers. Kegiatan dilaksanakan pada bulan Desember 2022 dengan menggunakan metode penyuluhan, diskusi dan praktik

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Stanzani-Maserati, Michelangelo, Maddalena De Matteis, Luca Bosco, et al. "“Build Your Village”—Conducting the Village Test on Cognitively Impaired Patients: A First Journey into Alzheimerland." Brain Sciences 14, no. 6 (2024): 523. http://dx.doi.org/10.3390/brainsci14060523.

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Background: This work aimed to study the Village Test (VT) in a group of patients with Alzheimer’s disease (AD) and compare the results with those of a group of patients with mild cognitive impairment (MCI) and controls. Methods: A total of 50 patients with AD, 28 patients with MCI, and 38 controls were evaluated. All participants underwent the VT and an extensive neuropsychological evaluation. Results: The mean ages of the participants were 74.4 years for those with AD, 74 for those with MCI, and 70.2 for the controls. The AD group built smaller and essential villages with a scarce use of pie

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Widyaningsih, Heriyanti, Sri Indah Lestyari, Alvi Ratna Yuliana, Biyanti Dwi Wanarsih, Sri Hartini, and Noor Faridah. "Pemberdayaan lansia melalui program deteksi dini gangguan fungsi kognitif." Jurnal PADE: Pengabdian & Edukasi 6, no. 2 (2024): 88. https://doi.org/10.30867/pade.v6i2.2114.

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Cognitive function is one of the problems that occurs in the elderly because physiologically as a person ages they will experience a decrease or disturbance in their nervous system due to disrupted oxygen supply to the brain, degenerative disease, Alzheimer's disease, malnutrition and impaired cognitive function including orientation to time, space, place and things. something new that is difficult to accept. Risk factors that can influence the decline in cognitive function are family heredity, level of education, brain injury, toxins, not doing physical activity, and chronic diseases such as

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Prayanti, Diorita Dyah, and Muhammad Hamdan. "Correlation Between Zinc Level and Cognitive Function Among the Pre Elderly." Journal of Computational and Theoretical Nanoscience 17, no. 7 (2020): 3108–12. http://dx.doi.org/10.1166/jctn.2020.9144.

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Zinc is required for various physiological and biochemical functions in the body. Although it is needed in the physiological processes of the body, deficiencies and excess levels of Zinc can harm humans. Excess levels of Zinc in the body can cause Alzheimer’s disease while Zinc deficiency can cause impaired cognitive function. This study aims to determine the correlation between Zinc levels with cognitive function among the pre-elderly in Bulak Village, Surabaya. The subjects were all elderly patients who visited Integrated Health Service Post of Elderly in Bulak, Kenjeran, and Surabaya from A

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Santoso, Andreas Putro Ragil, Devyana Dyah Wulandari, and Devyani Dyah Wulansari. "Hubungan Paparan Pestisida Terhadap Kadar Trigliserida Pada Petani Di Daerah Mojokerto." JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST 3, no. 1 (2020): 61. http://dx.doi.org/10.30651/jmlt.v3i1.4765.

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Alzheimer’s chronic generational neuro disease is indicated by the loss of neurons and synapses, factors that cause Alzheimer’s include cholesterol such as triglycerides and poisoning due to pesticides due to pesticides due to spraying activity. This study aimed to determine the extent of pesticide exposure to triglyceride levels in farmers in the Mojokerto area. This research is an observational type of research with an experimental approach. This research was conducted in Sumbersono Village, Dlanggu Subdistrict, Mojokerto Regency with 25 farmers who carried out spraying activities. This stud

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Cox, Paul Alan, David A. Davis, Deborah C. Mash, James S. Metcalf, and Sandra Anne Banack. "Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain." Proceedings of the Royal Society B: Biological Sciences 283, no. 1823 (2016): 20152397. http://dx.doi.org/10.1098/rspb.2015.2397.

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Neurofibrillary tangles (NFT) and β-amyloid plaques are the neurological hallmarks of both Alzheimer's disease and an unusual paralytic illness suffered by Chamorro villagers on the Pacific island of Guam. Many Chamorros with the disease suffer dementia, and in some villages one-quarter of the adults perished from the disease. Like Alzheimer's, the causal factors of Guamanian amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) are poorly understood. In replicated experiments, we found that chronic dietary exposure to a cyanobacterial toxin present in the traditional Chamorro

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Afgin, Anne E., Magda Massarwa, Edna Schechtman, et al. "High Prevalence of Mild Cognitive Impairment and Alzheimer's Disease in Arabic Villages in Northern Israel: Impact of Gender and Education." Journal of Alzheimer's Disease 29, no. 2 (2012): 431–39. http://dx.doi.org/10.3233/jad-2011-111667.

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S.Kirubakaran, S. Kirubakaran, K. Logeswari K.Logeswari, G. Aravind G.Aravind, M. Janaki M. Janaki, and J. Shanmuga Priya J. Shanmuga Priya. "Chronic Morbidity Pattern and Quality of Life among Geriatric Fisherman Population in Pondicherry-An Explanatory Sequential Mixed Method Study." BJKines National Journal of Basic & Applied Sciences 15, no. 01 (2023): 115–21. http://dx.doi.org/10.56018/202306118.

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Abstract Background: Almost half of the geriatric population in India has chronic morbidity. Health status is an important factor that has a significant impact on the quality of life of an elderly population. Objectives: To find out the pattern of chronic morbidities and to explore the coping skills among the Geriatric Population. Methodology: The study was Explanatory Mixed Methods study design, where a quantitative phase (Survey) followed by the qualitative phase (In depth interviews [IDI]) is used. A total of 450 patients aged 60 and above from the coastal villages were studied and analysed

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Kirubakaran, Dr S., Dr K. Logeswari, Dr G. Arvind, Dr M. Janaki, and Dr J. Shanmuga Priya. "Chronic Morbidity Pattern and Quality of Life among Geriatric Fisherman Population in Pondicherry-An Explanatory Sequential Mixed Method Study." BJKines National Journal of Basic & Applied Sciences 15, no. 01 (2023): 115–21. http://dx.doi.org/10.56018/20230618.

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Background: Almost half of the geriatric population in India has chronic morbidity. Health status is an important factor that has a significant impact on the quality of life of an elderly population. Objectives: To find out the pattern of chronic morbidities and to explore the coping skills among the Geriatric Population. Methodology: The study was Explanatory Mixed Methods study design, where a quantitative phase (Survey) followed by the qualitative phase (In depth interviews [IDI]) is used. A total of 450 patients aged 60 and above from the coastal villages were studied and analysed. Socio D

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Persad, Alyssa, Edward Hammel, Mitchell Roberts, et al. "ASSOCIATIONS BETWEEN THE GERIATRIC DEPRESSION SCALE AND APNEA-HYPOPNEA INDEX IN OLDER ADULTS." Innovation in Aging 7, Supplement_1 (2023): 995. http://dx.doi.org/10.1093/geroni/igad104.3198.

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Abstract The prevalence of sleep apnea increases with age and depression. Sleep plays an important role in memory consolidation, therefore, changes in sleep quality may play a contributing factor to neurodegenerative diseases such as Alzheimer’s. Findings from a retrospective analysis of a randomized control sleep study are presented for healthy participants (N=33) with no self-reported mental health conditions between 11/7/2022-6/7/2023. As part of a larger study, this sub-study occurred in The Villages in a partnership between the UFHealth PHRC and Applied Cognition. Participants completed t

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Tsor, JO, and GTA Jombo. "Heavy Metals Contaminating Vegetables in Nigerian Markets, Sources and Health Implications: A Search Perspective View." West J Med & Biomed Sci 3, no. 1 (2022): 9–22. https://doi.org/10.5281/zenodo.5905510.

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ABSTRACT Vegetables are common fresh foods available in any ordinary Nigerian market both in the cities, towns and villages and are widely consumed by all. The growing human activities put the quality of these vegetables in doubt especially from Heavy Metals (HMs) contamination with potential toxicity of these HMs in humans from ingestion of vegetables. This perspective view paper looked at HMs contamination of soils and vegetables consumed by Nigerians. Literature search was carried out on HMs contamination of soils and vegetables on electronic data bases of scientific articles such as google

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Hammel, Edward, Mitchell Roberts, Erica Sappington, et al. "ASSOCIATION OF RAPID EYE MOVEMENT SLEEP AND APOE PROTEOTYPE TO COGNITIVE PERFORMANCE IN OLDER ADULTS." Innovation in Aging 7, Supplement_1 (2023): 994. http://dx.doi.org/10.1093/geroni/igad104.3195.

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Abstract Exploring the multifaceted interaction of sleep, disease-related biomarkers and cognitive decline is of particular importance for aging populations. Sleep quality and the APOE E3/E4 allele has been linked to Alzheimer’s Disease (AD). This study aims to examine relationships between older adults’ level of cognitive performance, proportion of rapid eye movement (REM) sleep, and APOE proteotype. Analysis of sleep study data collected in an active lifestyle retirement community - The Villages, Florida was conducted using a subset of markers collected as part of a larger cognitive health s

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Hamad, Abdullah Alsheikh Ahmad Nueva Almutairy Abdullah ayidh Alotaibi Anas Saad Alsaab Dr.Syed Meraj Ahmed. "AWARENESS AND ATTITUDE TOWARDS PEOPLE WITH DOWN SYNDROME – A COMMUNITY BASED STUDY IN MAJMAAH, SAUDI ARABIA." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 820–27. https://doi.org/10.5281/zenodo.2537611.

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  <em>Down syndrome (DS) is a chromosomal disorder that results in intellectual disability and growth problems. The worldwide incidence of this syndrome is 1 in 1000 births and increases exponentially with the maternal age. People with DS usually have reduced life expectancy and suffer from mental retardation, heart problems, Alzheimer’s disease among other complications. So a cross-sectional study based on a questionnaire distributed to the participants which are the parents who are living in Almajmaah city and surrounding villages, and agreed to fill the questionnaire. The objecti

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Glicksman, Allen, Lauren Ring, and Sandra Torres. "LINKING ETHNIC MINORITY ELDERS TO PROGRAMS AND SERVICES: CHALLENGES TO BUILDING NETWORKS." Innovation in Aging 3, Supplement_1 (2019): S228. http://dx.doi.org/10.1093/geroni/igz038.839.

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Abstract Building networks that are effective in linking older adults to supportive programs and services often involves challenges related to access, eligibility requirements, the elder's ability to understand enrollment processes, and lack of trust in service providers. For ethnic minority elders these challenges are often greater due to additional linguistic and cultural barriers. The four presentations on this panel address challenges to building effective service networks for ethnic minority elders using data derived from focus groups with members of these communities and those tasked wit

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Ni Kadek Yuni Lestari, Yuni, Ni Luh Putu Thrisna Dewi, and Ni Made Era Mahayani. "The Effect of Feet Reflection Massage on Blood Pressure in Hypertension Patients at Community Health Centers II Petang." Nursing and Health Sciences Journal (NHSJ) 3, no. 1 (2023): 56–60. http://dx.doi.org/10.53713/nhs.v3i1.151.

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Complications of hypertension cause various health problems such as kidney damage, heart attack, stroke, glaucoma, erectile dysfunction, dementia and alzheimer's. One of the non-pharmacological treatments to avoid the long-term effects of hypertension is foot reflexology therapy. Foot reflexology therapy is a therapy that suppresses the zones and nerve points on the right and left soles of the feet. This study aims to determine the effect of foot reflexology on blood pressure in patients with hypertension. This type of research is a Quasi Experiment with a Non-Equivalent Control Group Design.

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Sönmez Gürer, Eda, Ayşe Esra Karadağ, Rengin Baydar, and Melek Demirel. "Investigation of the chemical composition, antioxidant and anticholinesterase activities of Consolida orientalis." Journal of Health Sciences and Medicine 7, no. 6 (2024): 691–95. https://doi.org/10.32322/jhsm.1536913.

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Aims: It is known that a decrease in the amount of acetylcholine in the body, which is known to be responsible for learning and cholinergic activity in the nervous system, causes Alzheimer’s disease. Acetylcholine is destroyed by acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzymes in the nervous system. Consolida orientalis (C. orientalis) is a species that belongs to the Ranunculaceae family and grows naturally in many parts of the world. It is known that it plays a role in many biological activities thanks to its content of important phytochemical components such as phenolic

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Niedzielski, Tomasz, Mirosława Jurecka, Bartłomiej Miziński, Wojciech Pawul, and Tomasz Motyl. "First Successful Rescue of a Lost Person Using the Human Detection System: A Case Study from Beskid Niski (SE Poland)." Remote Sensing 13, no. 23 (2021): 4903. http://dx.doi.org/10.3390/rs13234903.

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Recent advances in search and rescue methods include the use of unmanned aerial vehicles (UAVs), to carry out aerial monitoring of terrains to spot lost individuals. To date, such searches have been conducted by human observers who view UAV-acquired videos or images. Alternatively, lost persons may be detected by automated algorithms. Although some algorithms are implemented in software to support search and rescue activities, no successful rescue case using automated human detectors has been reported on thus far in the scientific literature. This paper presents a report from a search and resc

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Mazzola, Paolo, Gaia Ferraguzzi, Mariella Zanetti, and Giuseppe Bellelli. "AN INNOVATIVE MODEL OF CARE FOR SUBJECTS WITH DEMENTIA IN ITALY—IL PAESE RITROVATO—THROUGH THE SARS-COV-2 PANDEMIC." Innovation in Aging 6, Supplement_1 (2022): 410–11. http://dx.doi.org/10.1093/geroni/igac059.1613.

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Abstract “Il Paese Ritrovato” is an innovative long-term facility dedicated to subjects with mild-to-moderate Alzheimer’s disease or other dementias, located in Monza (Lombardia, Italy).By living in a village that resembles a community neighborhood, it aims at people’s wellbeing and represents a shift in the paradigm of traditional nursing home care, allowing the guests to visit the hair stylist, the supermarket, and various activities according to their personal habits, always supported by trained professionals.We performed a retrospective cohort study on 60 subjects, comparing their characte

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Carey, Cyriah, Erica Sappington, Mitchell Roberts, et al. "MALE AND FEMALE PERSPECTIVES: EXPLORING THE USE OF PASSIVE BRAIN HEALTH TECHNOLOGY TO MEASURE GLYMPHATIC FUNCTION." Innovation in Aging 7, Supplement_1 (2023): 1077. http://dx.doi.org/10.1093/geroni/igad104.3461.

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Abstract Older adults’ (OA) research participation is essential to gain insights into the causes, progression, and potential treatments of Alzheimer’s Disease (AD). Brain health technology, such as the Glymphatic Function (GF) Monitor, has the potential to measure the progression of AD. The GF Monitor is a multimodal in-ear dynamic impedance spectroscopy and electroencephalogram (EEG) system worn during sleep and records physiological signals: photoplethysmogram (PPG), bioimpedance (BioZ), and acceleration. This study aims to understand OA perceptions and perceived benefits of passive brain he

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Gray, William Keith, Stella-Maria Paddick, Adesola Ogunniyi, et al. "Population normative data for three cognitive screening tools for older adults in sub-Saharan Africa." Dementia & Neuropsychologia 15, no. 3 (2021): 339–49. http://dx.doi.org/10.1590/1980-57642021dn15-030005.

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ABSTRACT In sub-Saharan Africa (SSA),cognitive screening is complicated by both cultural and educational factors, and the existing normative values may not be applicable. The Identification of Dementia in Elderly Africans (IDEA) cognitive screen is a low-literacy measure with good diagnostic accuracy for dementia. Objective: The aim of this study is to report normative values for IDEA and other simple measures [i.e., categorical verbal fluency, the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) 10-word list] in representative community-dwelling older adults in SSA. Methods:

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Reichman, William E., L. Bradford Perkins, and Hilde Verbeek. "106 - Environmental Influences on the Cognitive and Psychological Well Being of Older Adults with Dementia." International Psychogeriatrics 32, S1 (2020): 15–16. http://dx.doi.org/10.1017/s1041610220001842.

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This symposium will review the latest data on the influence of environmental design and its attributes on the cognitive and psychological wellbeing of older adults living with dementia. The presenters will cover the myriad ways in which the physical environment of care can adapt to the changing demands of older adults with sensory, motor and cognitive deficits and foster optimal functioning and quality of life. The role of emerging technologies will also be reviewed as they complement the contribution of the design of the physical environment to the wellbeing of older adults with cognitive imp

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Anju Kumara and Dr. Vishnupriya Kannan. "The Effectiveness of an Information Booklet on Knowledge Regarding Management of Sleep Disturbances among Senior Citizens." International Journal of Scientific Research in Science and Technology 12, no. 2 (2025): 640–46. https://doi.org/10.32628/ijsrst251222608.

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BACKGROUND Aging is associated with multiple physiological changes, including alterations in sleep patterns. Sleep disturbances among elderly individuals can result in adverse health outcomes, including cognitive decline, depression, and cardiovascular diseases. Effective management strategies can significantly improve the sleep quality of senior citizens. INTRODUCTION Sleep is a naturally occurring altered state of consciousness characterized by decrease in awareness and responsiveness to stimuli. Sleep disturbances are prevalent among senior citizens, leading to a significant decline in thei

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LO, Ping Cheung. "儒家的生死價值觀與安樂死". International Journal of Chinese & Comparative Philosophy of Medicine 1, № 1 (1998): 35–73. http://dx.doi.org/10.24112/ijccpm.11324.

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LANGUAGE NOTE | Document text in Chinese; abstract also in English.在本文筆者要逐一檢討在西方四個常見的贊成安樂死的論據（仁是在、生命贊素、尊嚴、自決），並且指出這四個論據分別與中國儒家的價值觀（仁、所欲有甚於生、士可殺不可辱、泰山與鴻毛）有不同程度的共鳴及相通之處。由於這些共鳴及相通之處只是在某程度上，而非徹底相通，所以透過中國古代的價值觀的相對照，也可以更清楚看出這四個西方論據之性質及其可能限制。筆者的結論是，從儒家的價值觀來看，除了在某極端的情況中，一般來說這四個支持安樂死的論據都是說服力不足。This paper attempts to analyze four major arguments in favor of the moral acceptability of voluntary euthanasia (including physician-assisted-suicide) as found in the West, and tries to assess these arguments through Chinese Confucian ethics and its perspectives on life and death. Through such a cross-cultural di

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"Alzheimer : un village de répit touristico-médical." Ortho Magazine 21, no. 120 (2015): 11. https://doi.org/10.1016/s1262-4586(22)01014-7.

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Marie-Bailleul, G., and M. Bailleul. "Au Village Landais Alzheimer, écrire pour partager et transmettre." Éthique & Santé, May 2025. https://doi.org/10.1016/j.etiqe.2025.05.001.

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Pech, Marion, Céline Meillon, Manon Marquet, Jean‐François Dartigues, and Hélène Amieva. "The “Alzheimer Village”: Assessment of Alzheimer's disease representations in the general population: A cross sectional phone survey." Alzheimer's & Dementia: Translational Research & Clinical Interventions 8, no. 1 (2022). http://dx.doi.org/10.1002/trc2.12328.

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Pérès, K., G. Marie-Bailleul, S. Dreano-Hartz, V. Hernandez-Ruiz, and H. Amieva. "Dealing with the COVID-19 Pandemic in an Experimental Nursing Home: The Experience of the French Alzheimer Village." Journal of Nursing Home Research Sciences, 2025. https://doi.org/10.14283/jnhrs.2025.2.

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Marie-Bailleul, G. "Le Village Landais Alzheimer, une structure innovante pour faire société malgré la maladie cognitive et les troubles psycho-comportementaux." NPG Neurologie - Psychiatrie - Gériatrie, February 2022. http://dx.doi.org/10.1016/j.npg.2022.01.004.

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Mazzola, Paolo, Mariella Zanetti, Gaia Ferraguzzi, et al. "Shifting the Paradigm of Nursing Home Care for People with Dementia: The Italian Experience of Il Paese Ritrovato and the Impact of SARS-CoV-2." Journal of Alzheimer's Disease, December 18, 2023, 1–12. http://dx.doi.org/10.3233/jad-230229.

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Background: Il Paese Ritrovato is an Italian nursing home founded in 2018, it is based on the Alzheimer village model and admits people with mild-to-moderate dementia. Objective: Describe the impact of the SARS-CoV-2 pandemic on people living at Il Paese Ritrovato through a Comprehensive Geriatric Assessment (CGA) regularly administered prior to and during the pandemic. Methods: We explored the effects of a person-centered approach. We assessed 64 subjects (enrolled and followed between June 2018 and December 2020), who underwent at least 18 months of observation prior to the pandemic. Each su

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Chatterjee, Pratishtha, Steve Pedrini, James D. Doecke, et al. "The diagnostic and prognostic potential of plasma GFAP in older adults with subjective memory complaints at risk of Alzheimer’s disease." Alzheimer's & Dementia 19, S14 (2023). http://dx.doi.org/10.1002/alz.072740.

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AbstractBackgroundThe astrocyte cytoskeletal protein, Glial Fibrillary Acidic Protein (GFAP), is a potential blood‐based biomarker for diagnosis and prognosis of older adults in the Alzheimer’s Disease (AD) continuum, comprising cognitively unimpaired (CU) and cognitively impaired individuals with high brain amyloid‐beta load (Aβ+). However, specific attention to the potential of plasma GFAP in CU Aβ+ older adults with Subjective Memory Complaints (SMCs) is required, given that SMCs are a primary feature of Subjective Cognitive Decline (SCD) and individuals with SMCs are twice as likely to dev

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Therrien, Martine, Trevor Atkeson, Daniel Meyer, Sulagna Ghosh, Patrick Turley, and Beth Stevens. "New polygenic risk score for Alzheimer’s disease impacts states and functions in iPSC‐derived microglia." Alzheimer's & Dementia 19, S12 (2023). http://dx.doi.org/10.1002/alz.072650.

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AbstractBackgroundRecent genetics studies for Alzheimer’s disease have identified multiple risk variants affecting amyloid processing, immune response, lipid transport, and endocytosis, among others 1. More than half the risk genes associated with late‐onset AD are selectively expressed in microglia and peripheral myeloid cells. Yet, we know little about the underlying biology or how myeloid cells contribute to AD pathogenesis.MethodTo gain insights into the broad impact of genetics on microglia, we selected 50 cell lines from the CIRM biobank with variable APOE genotypes and polygenic risk sc

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Tuatoo, Grace. "Using a Community Based Participatory Research Approach to recruit American Samoans for Alzheimer’s Disease and Related Dementia Research." Alzheimer's & Dementia 20, S7 (2024). https://doi.org/10.1002/alz.089855.

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AbstractBackgroundThe Puipui Malu Manatu (PMM) study (RF1AG075904) is determining Alzheimer’s Disease and Related Dementias (ADRD) prevalence by administering cognitive assessment tools and determining prevalence of known genetic and plasma biomarkers. The sampling method uses a cluster and selection process to obtain a randomized sample of 1089 adults that is generalizable to the population. Research hesitancy exists due to historical abuse of non‐Indigenous researchers conducting studies that are not reflective of the community health needs. Community based participatory research (CBPR) appr

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Høilund-Carlsen, Poul F., Abass Alavi, Jorge R. Barrio, et al. "Revision of Alzheimer’s diagnostic criteria or relocation of the Potemkin village." Ageing Research Reviews, December 2023, 102173. http://dx.doi.org/10.1016/j.arr.2023.102173.

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Pal, S., T. Roy, and B. Guha. "Community NGO intervention for Alzheimer’s patients rehabilitation." Alzheimer's & Dementia 19, S23 (2023). http://dx.doi.org/10.1002/alz.072822.

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AbstractBackground Alzheimer’s patients Rehabilitation services aren’t well‐developed concept in resource‐Poor nations due to poor economics & lack of expertise. With limited resources we wanted to explore these rehabilitation services in rural villages. Rural/tribal areas of India lung Alzheimer’s patients [Ca] patients lack rehabilitation support available only in city hospitals. Our 12‐year CBO is training youth volunteers & traditional faith halers in marginalized communities to provide rehabilitation.MethodAround 1340 cases of Alzheimer’s will be in rural/tribal of India by 2025,

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Kresnasandi, Ida Bagus, and Brian B. Johnson. "Establishing a Remote Patient Monitoring Infrastructure with Starlink in Indonesia for the Aging Population to Improve Alzheimer’s and Dementia Care." Alzheimer's & Dementia 20, S10 (2024). https://doi.org/10.1002/alz.094355.

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AbstractBackgroundModernizing the remote patient monitoring (RPM) infrastructure in Indonesia has historically been limited by the unmet need of access to internet connectivity. New advancements made possible by Starlink and the internet of things (IoT) for RPM present new opportunities to connect people separated by geography and diverse cultural variations which includes over 700 languages and dialects. Alzheimer’s disease has increased by 87% from 2019 to 2022 and similar challenges in the United States apply to Indonesia; the cost of care, nurse shortage, and large aging population. Clinic

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Kresnasandi, Ida Bagus, and Brian B. Johnson. "Establishing a Remote Patient Monitoring Infrastructure with Starlink in Indonesia for the Aging Population to Improve Alzheimer’s and Dementia Care." Alzheimer's & Dementia 20, S7 (2024). https://doi.org/10.1002/alz.093132.

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AbstractBackgroundModernizing the remote patient monitoring (RPM) infrastructure in Indonesia has historically been limited by the unmet need of access to internet connectivity. New advancements made possible by Starlink and the internet of things (IoT) for RPM present new opportunities to connect people separated by geography and diverse cultural variations which includes over 700 languages and dialects. Alzheimer’s disease has increased by 87% from 2019 to 2022 and similar challenges in the United States apply to Indonesia; the cost of care, nurse shortage, and large aging population. Clinic

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Therrien, Martine, Nicolas Weider, Giulia Monti, et al. "Identification of regulators of microglia lipotoxicity." Alzheimer's & Dementia 20, S1 (2024). https://doi.org/10.1002/alz.089632.

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AbstractBackgroundEmerging studies have identified changes in lipid processing in Alzheimer’s disease patients. However, how the various brain cell types respond to these changes is unclear. Multiple Alzheimer’s disease risk genes are expressed in microglia and involved in lipid sensing and processing.MethodIn this project, we assessed unbiasedly how various fatty acids impact microglia states and functions. Using the iPSC‐derived microglia platform, our lab has recently developed (Dolan*, Therrien* et al. Nature Immunology 2023), we characterized the impact of 48 different fatty acids on huma

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Utomo, Bedjo, Liliek Soetjiatie, Heru Sulistijono, and Nurul Hindaryani. "Gymnastics Assistance for the Independent Elderly: Service in Efforts to Prevent Dementia in Bulak Village, Surabaya." Frontiers in Community Service and Empowerment 3, no. 2 (2024). http://dx.doi.org/10.35882/ficse.v3i2.58.

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Degenerative diseases are infections that almost occur in old age, with decreased physiological function will have an impact on several chronic diseases, such as hypertension, diabetes, osteoarthritis, Alzheimer's, heart disease, kidney failure, therefore, to prevent the occurrence of these diseases it is necessary to strive for promotive, preventive, and rehabilitative measures. One of the efforts made is to carry out community service in the form of assisting the elderly so that they can live independently and have a good quality of life. Community service for Departemen of health Poltekkes

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Bart, William. "Chess Training for the Elderly: Insights and Prospects as a Dementia Preventive Treatment." Medical Research Archives 11, no. 7.2 (2023). http://dx.doi.org/10.18103/mra.v11i7.2.4138.

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This article reviews research on chess training as a treatment to promote cognitive fitness and to delay the onset of dementia among the elderly. Alternative treatments are needed to address the widespread problem of dementia among the elderly, primarily because all drug treatments developed thus far to cure or delay dementia have been deemed either unsuccessful or unsafe. Chess training augmented by artificial intelligence is presented as an alternative treatment to address the dementia crisis. Computer-based technology and open-source chess software such as Stockfish 14 with the artificial i

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Lwere, Kamada. "APOE Genotypes and Alzheimer’s Disease Risk in Older Ugandans." Alzheimer's & Dementia 20, S1 (2024). https://doi.org/10.1002/alz.092112.

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AbstractBackgroundApolipoprotein E (APOE) gene has three common alleles: ԑ2, ԑ3, and ԑ4, which influence Alzheimer’s disease (AD) risk. APOE ԑ4 allele increases AD risk, while APOE ԑ2 allele may protect against AD. This study aimed to examine the distribution and prevalence of APOE genotypes and their association with AD in older Ugandans.MethodForty‐three participants aged ≥ 65 years were recruited from two villages in Wakiso district, Uganda. Suspected AD cases were identified using the Montreal Cognitive Assessment (MoCA) tool. APOE genotypes were determined from blood samples using molecul

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Pal, S., B. Guha, and T. Roy. "Managing Alzheimer’s patients in rural areas of developing country." Alzheimer's & Dementia 19, S23 (2023). http://dx.doi.org/10.1002/alz.072830.

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AbstractBackgroundNational‐health‐registry based data demonstrates Psychosocial support & treatment‐availability are major issues for Alzheimer’s ‐sufferers in resource‐poor‐nations. Hence our Non‐Government‐Organisation analysed & made this public health‐policy paper recommendation’s.NGO’s are close to rural/tribal‐communities. Cost of running NGO is economical than medical‐institution. Medical treatment cost is prohibitive and inaccessible for majority patients in Asia. Government‐Health‐Departments need to workout strategy to increase access to care.In resource‐poor‐setting unafford

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Sohrabi, Hamid R., Kathryn G. Goozee, Michael Weinborn, Stephanie Rainey Smith, Kevin Taddei, and Ralph N. Martins. "Does education years delay Alzheimer’s disease in cognitively normal oldest old?" Alzheimer's & Dementia 20, S4 (2024). https://doi.org/10.1002/alz.089080.

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AbstractBackgroundResearch on cognitive reserve (CR) in individuals aged 80 years old and above has resulted in inconsistent findings, mostly showing a relationship with baseline cognitive abilities but not follow up assessments. The effects of amyloid burden on the relationship between CR, cognitive decline and dementia in oldest old warrants further study in the presence of APOE e4. We hypothesised that CR in oldest old (≥80 yrs old) adults will result in different trajectories, depending on being amyloid PET positive or negative. Specifically, this study was to determine whether the relatio

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Sharmin, Tahmida, James D. Doecke, Pratishtha Chatterjee, et al. "Plasma metabolites associated with plasma P‐tau181 in preclinical Alzheimer's disease." Alzheimer's & Dementia 20, S2 (2024). https://doi.org/10.1002/alz.091167.

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AbstractBackgroundAlzheimer's disease (AD) pathogenesis is not restricted to amyloid‐beta, Aβ, and tau pathologies but involves dysregulation in diverse cellular and molecular processes. Numerous metabolomic studies revealed plasma metabolite alterations in AD individuals compared to healthy controls. Nevertheless, plasma P‐tau181, an established biomarker for AD diagnosis and prognosis, has been described to reflect initial multiple cortical region Aβ deposition in cognitively intact adults. The current study aims to identify plasma metabolites associated with plasma P‐tau181 at the preclinic

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Croney, Ruth, Emil Fristed, Donna Masterman, et al. "ADNI Private Partners Scientific Board (PPSB) Diversity, Equity, and Inclusion (DE&I) Working Group: A new collaboration that crosses boundaries for industry, academia, and under‐represented patients." Alzheimer's & Dementia, December 22, 2024. https://doi.org/10.1002/alz.14248.

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AbstractThe Alzheimer's Disease Neuroimaging Initiative (ADNI) Private Partners Scientific Board (PPSB) Diversity, Equity, and Inclusion Working Group (DE&I WG) was established to work with the ADNI3 Diversity Task Force to provide an industry perspective on increasing the representation of diverse participants in ADNI3 and to build precompetitive cross‐industry knowledge in engagement and recruitment of under‐represented participants (URPs). In this article, we review and highlight the role and ongoing activities within the ADNI PPSB DE&I WG and provide a cross‐industry perspective on

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Kristian, Kevin, Yvonne Suzy Handajani, Nelly Tina Widjaja, Ika Suswanti, and Yuda Turana. "DEVELOPMENT OF STANDARDIZED OLFACTORY TEST AS A COGNITIVE IMPAIRMENT SCREENING TOOL IN INDONESIAN ELDERLY: A PRELIMINARY STUDY." Berkala Ilmiah Kedokteran Duta Wacana 9, no. 1 (2024). http://dx.doi.org/10.21460/bikdw.v9i1.631.

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The decline of olfactory function is an early indicator of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. An olfactory function assessment instrument using ten familiar scents with multiple-choice answers has been developed, but several items were inapplicable and had not been standardized. This study aimed to identify various scents that have not been standardized for the aging population with normal cognitive function. This research was a preliminary study with a descriptive cross-sectional approach conducted in Kalianyar village, Jakarta, involving 23 elderly parti

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