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Rozprawy doktorskie na temat „Viral genetics”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Beier, Kevin. "Viral Tracing of Neuronal Circuitry." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10241.

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To understand how the nervous system processes information, a map of the connections among neurons is essential. Viral transsynaptic transmission has gained popularity as a method for labeling neural circuits. In particular, the development of retrograde monosynaptic tracing vectors has enabled visualization of the pre-synaptic inputs onto defined sets of postsynaptic neurons. This system utilized the rabies virus (RABV), in which the glycoprotein gene in the virus was deleted, and re-supplied in trans. In order to build alternative, more flexible tracers, we made recombinant VSV genomes, firs

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2

James, Katherine Louise. "Viral genetics of HIV-2 infection." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:68ba022d-62e4-4cb1-8032-085ea5240b98.

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HIV-2 is a contemporary human retrovirus with the majority of infections localised to West Africa. Both HIV-1 and HIV-2 are able to cause AIDS; however, in contrast to HIV-1 infection, a common outcome following HIV-2 infection (&Tilde; 37&percnt; of patients in this study cohort) is long-term non-progression (LTNP), where patients remain aviraemic and asymptomatic in the absence of treatment, often for decades. HIV-1 and HIV-2 both arose following zoonotic transmission of SIVs from non-human primates at around the beginning of the 20<sup>th</sup> century and when patients develop AIDS caused

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3

Mills, Ryan E. "Improving gene annotation of complete viral genomes." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/25189.

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4

Wilson, Jamie Douglas Knox. "Oligoclonal expansions of T lymphocytes during viral infections." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299227.

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5

Mistry, Ajay Ramanlal. "Development of non-viral gene delivery systems based on HMG1." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368705.

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6

Ma, Hok-tsun, and 馬學俊. "RNA-Dependent RNA polymerase activity of the infectious bursal diseasevirus viral protein 1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30408192.

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7

Upton, John H. "The role of RNA secondary structure in replication of Nodamura virus RNA2." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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8

Shi, Bu-Jun. "Expression and function of cucumoviral genomes." Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phs5546.pdf.

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Bibliography: leaves 104-130. The aim of this thesis is to characterise subgenomic RNAs of cucumoviruses and the functions of their encoding genes. Strains of cucumber mosaic virus (CMV) are classified into two major subgroups (I and II) on the basis of nucleotide sequence homology. The V strain of tomato aspermy virus (V-TAV) and a subgroup I CMV strain (WAII) are chosen to determine whether the 2b genes encoded by these viruses are expressed 'in vivo'. For further investigation of the 2b gene function, cDNA clones of three genomic RNAs of V-TAV are constructed. Using the infectious cDNA clon

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9

Song, Rujun. "Dimerization of human immunodeficiency virus type 1 genome : dimer maturation process and role of the 5' untranslated region in dimerization." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111918.

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Human Immunodeficiency Virus type I genome consists of two identical RNA molecules that are non-covalently linked to form a dimer. HIV-1 immature and mature genomic RNA (gRNA) dimers were found in protease defective (PR -) and wild type virions, respectively, and the 5'untranslated region (5' UTR) was shown to play key roles during the genome dimerization process; but the dimerization mechanism still remains to be clarified My research project is to characterize the dimerization process and the role of 5' UTR in genome dimerization in virions produced by tissue culture cells. I'll firstly show

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10

Lai, King-yin, and 賴景然. "Discovery and complete genome sequence of a novel group of bat picornavirus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44546026.

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11

Dutta, Ranendra Nath. "Experimental Test of Solitary Wave Theory in Viral Populations." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1226950654.

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12

Bawazir, Amin Ahmed. "Epidemiology, immunology and genetics of viral hepatitis in Aden City, Yemen." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507582.

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Background: Viral hepatitis is a significant public health problem with millions of humans infected worldwide. There are very few studies of hepatitis in Aden, Yemen. Aims: The study aims to determine the prevalence of viral hepatitis (A, B, e and E), their co-infection with Epstein - Barr virus (EBV), cytomegalovirus (eMV) and human herpes virus (HHV6) and the risk factors for HBV infection among individuals attending primary health care facilities. Risk factors for HBV and Hev infection were also identified in patients with chronic liver disease (eLO), multi-transfusions and those undergoing

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13

Biryahwaho, B. "Analysis of RNAs and proteins of rotaviruses with rearranged genomes : A study of molecular variability." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380397.

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14

Rider, Janet Rosemary. "Isolation and characterisation of human cytomegalovirus envelope glycoproteins." Thesis, University of Reading, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328918.

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15

Cornish, Julie Anne. "An investigation into the catalytic mechanism of the adenovirus type II proteinase." Thesis, University of St Andrews, 1996. http://hdl.handle.net/10023/13939.

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A series of P4 (Cbz and t-Boc) N-protected potential substrates and inhibitors, containing the P1 to P4 substrate recognition sequence of the type 2 adenovirus proteinase (Leu-Ala-Gly-Gly) were prepared by solution phase peptide coupling techniques and tested for activity against the proteinase. The potential substrates contained the amide and ester moieties at the P1 carbonyl position and the potential inhibitors contained the alcohol, acid, bromide, aldehyde, ketone, dimethylacetal, nitrile, alkenic, malonyl and epoxysuccinate moieties at the P1 carbonyl position. The esters, the t-Boc ureth

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16

Monaghan, Alan. "Mechanisms of adenovirus DNA replication." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/13935.

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The development of a cell-free system in which adenovirus DNA synthesis can be initiated in vitro by using the viral genome or plasmids containing the origin of replication as template has led to the identification of the sequences important for origin function and the isolation and purification of the proteins required for viral DNA replication. In vitro studies on adenovirus types 2 and 5 have shown that their replication requires the formation of a large nucleoprotein complex. This is composed of three virally encoded proteins: adenovirus DNA polymerase, precursor terminal protein and DNA b

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17

Temperley, Simon M. "A study of the in vitro initiation of adenovirus DNA replication." Thesis, University of St Andrews, 1992. http://hdl.handle.net/10023/13929.

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The development of systems in which adenovirus DNA can be replicated in vitro has led to the elucidation of the sequences essential for origin function and to the identification of the proteins required for viral DNA replication. Much of the information currently available has been derived from investigations carried out using adenovirus types 2 and 5 which in addition to the viral proteins, adenovirus DNA polymerase, precursor terminal protein and DNA binding protein, require cellular proteins nuclear factor I and nuclear factor III for efficient initiation of DNA replication. In contrast ade

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18

Wahyuni, Wiwiek Sri. "Variation among cucumber mosaic virus (CMV) isolates and their interaction with plants." Title page, contents and summary only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phw137.pdf.

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Includes appendix containing journal publications co-authored by the author. Includes bibliographical references (leaves 130-151). Eighteen strains of Cucumber mosaic virus, including forteen from Australia, two from the USA, and two from Japan were used in this study.

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19

Williams, Rhys Harold Verdon George. "Further studies on the structure and function of the cucumber mosaic virus genome : a thesis submitted to the University of Adelaide, South Australia for the degree of Doctor of Philosophy." 1988, 1988. http://web4.library.adelaide.edu.au/theses/09PH/09phw7261.pdf.

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20

Smith, Sarah D. "Selection of Generalists and Specialists in Viral Quasispecies." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1224018547.

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21

Choudhury, Sourav Roy. "Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/809.

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Neurological disorders – disorders of the brain, spine and associated nerves – are a leading contributor to global disease burden with a sizable economic cost. Adeno-associated viral (AAV) vectors have emerged as an effective platform for CNS gene therapy and have shown early promise in clinical trials. These trials involve direct infusion into brain parenchyma, an approach that may be suboptimal for treatment of neurodegenerative disorders, which often involve more than a single structure in the CNS. However, overall neuronal transduction efficiency of vectors derived from naturally occurring

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22

Choudhury, Sourav Roy. "Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/809.

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Neurological disorders – disorders of the brain, spine and associated nerves – are a leading contributor to global disease burden with a sizable economic cost. Adeno-associated viral (AAV) vectors have emerged as an effective platform for CNS gene therapy and have shown early promise in clinical trials. These trials involve direct infusion into brain parenchyma, an approach that may be suboptimal for treatment of neurodegenerative disorders, which often involve more than a single structure in the CNS. However, overall neuronal transduction efficiency of vectors derived from naturally occurring

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23

Lorson, Christian. "An analysis of transcriptional regulation of the MVM capsid gene promoter." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841319.

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24

Bull, James Christopher. "A study of the population genetics of nucleopolyhedrovirus infections within infected insects." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274938.

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25

Ligat, Julio S. "Pathology and distribution in the host of pea seed-borne mosaic virus." Title page, contents and summary only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phl723.pdf.

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Includes bibliographical references (leaves 82-92). Five isolates of pea seed-borne mosaic virus were compared by host range and symptomatology on 16 pisum sativum cultivars lines, 21 lines of Lathyrus and Lens spp. and several indicator species

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26

Hajimorad, Mohammad Reza. "Variation in alfalfa mosaic virus with special reference to its immunochemical properties." Title page, contents and summary only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09phh154.pdf.

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Includes Appendix listing other publications by the author. Includes bibliographical references (leaves 134-181). Alfalfa mosaic virus was isolated from lucerne (Medicago sativa) plants with a variety of disease symptoms. Experiments showed that each isolate was biologically distinct and that the host range and symptomatology of each isolate was affected by the environmental condition.

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27

Chilton, Jamie Meredith. "Investigation of the limitations of viral gene transfer to murine embryonic stem cells." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/29745.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Joseph Le Doux; Committee Member: Anthanassios Sambanis; Committee Member: David Archer; Committee Member: Michelle LaPlaca; Committee Member: Steve Stice; Committee Member: Todd McDevitt. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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28

Bergner, Laura. "Viral communities in vampire bats : geographical variation and ecological drivers." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30811/.

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Microbial communities play important roles in organismal and ecosystem health. High throughput sequencing has revolutionized our understanding of host-associated microbial communities, but the viral component of these communities remains poorly characterized relative to microbes such as bacteria, particularly in non-human hosts. This knowledge gap has implications for global health, as viruses originating in wildlife are responsible for recent disease outbreaks in humans and domestic animals. Although studies have identified factors differentiating viral communities between species, we have li

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29

Ramaley, Patricia A. "Host genetics of HIV-1 infection and disease progression in Uganda." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365714.

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30

Carlsson, Beatrice. "Human Caliciviruses: a study of viral evolution, host genetics and disease susceptibility." Doctoral thesis, Linköpings universitet, Molekylär virologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76036.

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The viruses described in this thesis are the norovirus and sapoviruses, which belong to the family of human caliciviruses and are known to cause gastroenteritis in humans. Gastroenteritis has emerged as a global health problem and is based on the large number of infected considered as one of the most common diseases today. According to estimates of the World Health Organization (WHO), gastroenteritis causes over five times more pediatric deaths compared to pediatric deaths caused by HIV/AIDS worldwide. Norovirus, the cause of the famous “winter vomiting disease”, is alone responsible for more

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31

Fok, Yuen-kei Vivien. "Expression of human herpesvirus 6 (HHV-6) genes in virus-infected cells /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31385515.

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32

Lee, Paul. "Molecular epidemiology of human coronavirus OC43 in Hong Kong /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38348342.

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33

Fok, Yuen-kei Vivien, and 霍沅琪. "Expression of human herpesvirus 6 (HHV-6) genes in virus-infected cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010006.

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34

Hampson, J. "A study of the genetics and growth of a tripartite RNA virus using ts mutants." Thesis, University of Warwick, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380288.

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35

Wakeford, Laura 1956. "COMPLEMENTATION BETWEEN TEMPERATURE-SENSITIVE MUTANTS OF POLIOVIRUS." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276556.

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Conditional lethal mutants of poliovirus type 1 (Mahoney) were generated by treatment with the mutagen hydroxylamine. Temperature-sensitive mutants were selected by the replica plating technique at temperatures of 33°C (permissive) and 39°C (restrictive). New mutants were generated to achieve a larger population of mutants and also to generate additional RNA- mutants in this population. These mutants were characterized by two criteria: RNA synthesis and thermal stability. RNA synthesis is measured by the accumulation of labeled uridine incorporation into trichloroacetic acid (TCA) insoluble ma

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36

Tajbakhsh, Shahragim Carleton University Dissertation Biology. "Isolation and characterization of the Tipula Iridescent Virus capsid gene." Ottawa, 1988.

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37

de, Groot Saskia Elizabeth. "Genome annotation and selectional analysis of viral evolution." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:9bc1f480-5556-4f44-8700-8c230a5dbda9.

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In the past few years we have witnessed an explosion in the viral genomic data available. GenBank alone holds over 80,000 close to complete viral genomes, and numbers are rising fast. For example, since the submission of the first SARS genome in May 2003, over 140 more have been published. With this genomic data at hand we hope to finally be able to improve our understanding of viruses. Several papers have been dedicated to the study of genome annotation and selection on viral genomes, in particular focusing attention on the evolutionary behaviour of overlapping reading frames. This is a featu

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38

Deleris, Angélique. "Genetics of antiviral RNA silencing in Arabidopsis through an analysis of the P38 viral suppressor." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13034.

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39

Wong, Hoi-man Emily, and 黃凱敏. "Codon usage biases of influenza A viruses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43572200.

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40

Wong, Hoi-man Emily. "Codon usage biases of influenza A viruses." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43572200.

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41

Behjatnia, Seyyed Ali Akbar. "Characterisation of DNA replication of tomato leaf curl geminivirus /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09ACP/09acpb419.pdf.

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42

Arnoldi, Francesca. "Interaction of rotavirus nonstructural protein NSP5 with the viral replication complex." Doctoral thesis, Scuola Normale Superiore, 2008. http://hdl.handle.net/11384/85952.

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Rotavirus morphogenesis starts in intracellular inclusion bodies called viroplasms, where synthesis of the11 dsRNA genome segments and their packaging in new viral particles take place. RNA replication is mediated by several viral proteins, of which VP1, the RNA-dependent RNA polymerase, and VP2, the core scaffolding protein, were shown to be sufficient to provide replicase activity in vitro. In vivo, however, viral replication complexes also contain the nonstructural proteins NSP2 and NSP5, which were shown to be essential for replication, to interact with each other and to form viropl

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43

Yeung, Yin-shan. "Molecular characterization of apoptosis induced by severe acute respiratory syndrome coronavirus spike protein." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38302366.

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44

Burnight, Erin Rae. "Targeting therapeutic vector expression and integration for gene therapy applications." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2831.

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Gene therapy is an attractive treatment for many genetic diseases because rather than treat the symptoms of the disease, it has the potential to correct the underlying defect. Cystic fibrosis and hemophilia A are two monogenic disorders that are particularly well-suited to treatment with gene therapy as a relatively small increase in the function is needed to see improvement. Gene therapy has provided some correction in both diseases using a variety of vector systems but sustained expression and long term correction have y

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45

Lam, Suk-fun, and 林淑芬. "Discovery and complete genome sequence of a novel group ofcoronavirus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41633647.

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Lam, Suk-fun. "Discovery and complete genome sequence of a novel group of coronavirus." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41633647.

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47

Urbani, Nicola. "Association of endogenous viral genes and myb-gene polymorphisms with disease resistance in white leghorns." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56818.

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The incidences of endogenous viral genes (ev-genes) and myb-gene polymorphisms were determined in substrains of strains R, M and G which had been divergently selected or susceptibility to tumour formation induced by Rous Sarcoma virus (RSV) of type A and B. Frequencies of myb gene polymorphisms were also determined in two replicates of strains selected for high and low multiple immune response to challenge with Pasteurella multocida and Mycoplasma gallisepticum. Strains R, M and G were found to contain different sets of ev-genes reflecting their distinct genetic origins. Among eleven ev-genes

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48

Dennis, Tristan Philip Wesley. "Mining genome data for endogenous viral elements and interferon stimulated genes : insights into host virus co-evolution." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30887/.

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Paleovirology is the study of viruses over evolutionary timescales. Contemporary paleovirological analyses often rely on sequence data, derived from organism genome assemblies. These sequences are the germline inherited remnants of past viral infection, in the form of endogenous viral elements and the host immune genes that are evolving to combat viruses. Their study has found that viruses have exerted profound influences on host evolution, and highlighted the conflicts between viruses and host immunity. As genome sequencing technology cheapens, the accumulation of genome data increases, furth

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49

Terenius, Olle. "Anti-parasitic and anti-viral immune responses in insects." Doctoral thesis, Stockholm : Institutionen för genetik, mikrobiologi och toxikologi, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-224.

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50

Geering, Andrew D. W. "The epidemiology of cucumber mosaic virus in narrow-leafed lupins (Lupinus angustifolius) in South Australia." Title page, table of contents and summary only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phg298.pdf.

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