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Artykuły w czasopismach na temat „While 12 [25.6%] were died during their hospital stay. However”

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Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

ZAHRA, M., A. MUNIR, S. CHOUDHRY, et al. "CLINICAL SPECTRUM OF DISEASE IN NEONATES BORN TO MOTHERS WITH COVID-19 IN A TERTIARY CARE HOSPITAL." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1117. http://dx.doi.org/10.54112/bcsrj.v2024i1.1117.

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COVID-19 infection during pregnancy presents potential risks to neonates, yet the full clinical spectrum in newborns born to COVID-19-positive mothers remains under investigation. Understanding the clinical outcomes in these neonates is essential for guiding management and care. Objective: To study the spectrum of clinical presentations in neonates born to mothers who tested positive for COVID-19. Methods: This prospective cross-sectional study was conducted at the Department of Pediatrics, Shifa International Hospital, from April 1, 2020, to April 30, 2021. All neonates born to COVID-19-posit

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Bhat, Imtiyaz Ahmad, Moomin Hussain Bhat, Shariq Rashid Masoodi, et al. "Acute and Chronic Posterior Pituitary Insufficiency Among Traumatic Brain Injury Patients at a Tertiary Care Center." Journal of the Endocrine Society 5, Supplement_1 (2021): A623. http://dx.doi.org/10.1210/jendso/bvab048.1270.

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Abstract Background: Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. Disorders of salt and water balance are the most commonly recognized medical complications in the immediate post-TBI period and contribute to early morbidity and mortality. Objective: We aimed to evaluate the prevalence of acute (during hospital stay) and chronic posterior pituitary dysfunction in patients of head injury admitted at our tertiary care hospital. Study Design: Prospective, Observational study. Participants: 136 patients, attending tertiary care in North India with TBI w

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Dr., Shazad Najeeb Dr. Arshad Sohail DR. Muhammad Ali Raza Dr. Chetan Das Priya Hotwani Dr. Suresh Kumar Rathi*. "FREQUENCY OF NECROTIZING ENTEROCOLITIS IN PRETERM NEONATES AND THEIR OUTCOME DURING HOSPITAL STAY." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2087–94. https://doi.org/10.5281/zenodo.835557.

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Background: Neonatal necrotizing enterocolitis [NEC], characterized by intestinal necrosis and pneumatosis intestinal, is the most common gastrointestinal emergency in the premature newborns[1] . The disease has an incidence rate of 2 to 5% in premature infants. The incidence rate increases to 13% in those weighing 1,500 gram at birth. NEC has a mortality rate of 10 to 55%. Objective: To determine the frequency of necrotizing enterocolitis in preterm neonates along with their outcome during stay in hospital. Methods: All premature newborn with morbidity admitted at Neonatal Intensive Care Unit

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Le, Jennifer, Tu T. Tran, Ivilynn Bui, Mike K. Wang, Andrew Vo, and Felice C. Adler-Shohet. "Time to Initiation of Antifungal Therapy for Neonatal Candidiasis." Antimicrobial Agents and Chemotherapy 57, no. 6 (2013): 2550–55. http://dx.doi.org/10.1128/aac.02088-12.

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ABSTRACTThe effect of delayed antifungal therapy in critically ill infants with invasive candidiasis has not been studied. Our objective was to evaluate the effect of time to initiation of antifungal therapy (TIA) on mortality, disseminated disease, and postinfection hospital stay. We conducted a cohort study of critically ill infants with cultures positive forCandidafrom 1990 to 2008. TIA was defined as the number of hours from the collection of the first positive culture until the start of antifungal therapy. Of 96 infants, 57% were male, the median gestational age was 27 weeks (range, 23 to

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Akpanudo EI, Ituen AM, Eyo AE, and Emmanuel EM. "Ileostomies for severely ill children with ileo-colic intussusception: our experience at the University of Uyo Teaching Hospital." Ibom Medical Journal 17, no. 2 (2024): 251–59. http://dx.doi.org/10.61386/imj.v7i2.432.

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Context: Complicated intussusception is associated with life-threatening intestinal gangrene and peritonitis. In critically ill children, a primary ileocolic anastomosis may increase their morbidity and mortality and, thus, a temporary ileostomy may be a safer option. Objective: The purpose of this study is to report the indications, outcomes, and complications after temporary ileostomies for infants with ileocolic intussusception in our institution. Materials and methods: This was a retrospective study of infants who had ileostomies created in our institution following complicated ileocolic i

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Medam, Rajesh Babu, Venugopal Reddy Iragamreddy, Akhila H. B., and Murali Mohan Voona. "Effect of inhaled budesonide therapy in term newborns with meconium aspiration syndrome." International Journal of Contemporary Pediatrics 10, no. 7 (2023): 1033–39. http://dx.doi.org/10.18203/2349-3291.ijcp20231838.

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Background: Meconium aspiration syndrome is a common cause of respiratory distress in neonates. This study explores the possibility of altering the course of the disease by using anti-inflammatory agents to counter the chemical and inflammatory pneumonitis caused by meconium. The objective is to determine if inhaled budesonide therapy can alter the clinical course of the disease and improve outcome without causing any serious adverse effects. Methods: A comparative study was conducted in NICU of Cheluvamba hospital, Mysore over 12 months. Neonates with MAS were divided into interventional and

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Shah, Sunish, Dayna McManus, Nika Bejou, et al. "2645. Clinical Outcomes of Oseltamivir vs. Baloxavir in Patients Hospitalized with Influenza A." Open Forum Infectious Diseases 6, Supplement_2 (2019): S925. http://dx.doi.org/10.1093/ofid/ofz360.2323.

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Abstract Background Baloxavir marboxil is a new antiviral agent for the treatment of acute uncomplicated influenza in patients > 12 years of age who have been symptomatic for no more than 48 hours. However, clinical trials to date have excluded patients hospitalized with influenza infection. Methods This study was a multi-center, retrospective chart review of adult patients admitted to the hospital who received oseltamivir or baloxavir for the treatment of influenza A. Patients were screened for inclusion between January 2018 and February 2018 in the oseltamivir group while patients in the

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AFTAB, RUSHDA. "NEONATAL SEIZURES." Professional Medical Journal 14, no. 02 (2007): 199–203. http://dx.doi.org/10.29309/tpmj/2007.14.02.4868.

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Introduction: Seizures in the neonates are quite different from those in older children and adults,whereas seizures in preterm differ from those of term infant. Neonatal seizures are poorly organized and at timesinconspicuous, they also differ in origin from those of older children as they frequently arise in subcortical areas whilein older children they arise from cortex. Objective: To find out the frequency of seizures and determine the frequencyof various types of neonatal seizures among newborns admitted to Nishtar Hospital, Multan. Material and Methods:Setting: Pediatric Unit-I, Nishtar H

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Lazar Neto, Felippe, Cassio Murilo Trovo Hidalgo Filho, Joao Wilson Da Rocha, Renata Colombo Bonadio, and Paulo Marcelo Hoff. "Hospitalization and post-discharge survival outcomes of adolescents and young adults with cancer." Journal of Clinical Oncology 40, no. 16_suppl (2022): e18687-e18687. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e18687.

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e18687 Background: Cancer incidence has increased among adolescents and young adults (AYA) over the last two decades. Younger patients often present with late diagnosis, aggressive disease, and are more likely to receive chemotherapy during cancer treatment. We investigated admission outcomes and post-discharge survival of AYA who were hospitalized after urgent admission. Methods: Retrospective cohort of patients with solid tumor diagnosis and age between 18 and 39 years, hospitalized after urgent admission to a tertiary, publicly-funded, cancer hospital in São Paulo, Brazil, from February 1st

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Abu Freha, Naim, Muhammad Abu Tailakh, Doron Schwartz, et al. "Accidental Hijab Pin Ingestion: 10 Years Experience from a Tertiary Care Centre." Integrative Gastroenterology and Hepatology 1, no. 1 (2018): 54–59. http://dx.doi.org/10.18314/igh.v1i1.1178.

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Background and Aim: Hijab pins ingestion is increasing. Some women hold the pin between their teeth while arranging the Hijab and the inadvertent ingestion of the pin can be the result of any careless movements. The aims of our study were to investigate the clinical outcomes of patients who underwent endoscopic pin removal via gastroscopy as opposed to patients who were treated conservatively with clinical observation, and to compare clinical and endoscopic data pertaining to patients who underwent early versus late gastroscopy.Methods: Muslim women hospitalized in a tertiary hospital from 200

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Ahmad, Mir Mujtaba, Raja Nadeem, Musharraf Husain, Irfan Nazir, and Manzoor Ahmad. "Stapled haemmorhoidopexy versus open haemorrhoidectomy: our initial experience." International Surgery Journal 4, no. 5 (2017): 1672. http://dx.doi.org/10.18203/2349-2902.isj20171619.

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Background: Haemorrhoids or ‘Piles’ is a frequently observed disease in surgical practice. Various non-surgical and surgical treatments are available. Open haemorrhoidectomy (Milligan-Morgan) is a widely-used procedure. A recent novel technique called ‘Stapled haemorrhoidopexy’, first described and performed by Italian surgeon Antonio Longo is gaining worldwide recognition for its benefits.Methods: A total of 155 patients between the age group of 20 and 65 years, diagnosed to have grade III or IV haemorrhoids were included in the study, divided into 2 groups, Group 1 undergoing Open haemorrhoi

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Ali, Shabahat, Rana Muhammad Umar, Furqan Yaqub Pannu, Faryad Ali, Qazi Abdul Saboor, and Bilal Ahmed. "Frequency of Acute Kidney Injury in Patients Presenting with Acute ST-Elevation Myocardial Infarction and Its Relationship with In-Hospital Mortality." Pakistan Journal of Medical and Health Sciences 16, no. 11 (2022): 224–27. http://dx.doi.org/10.53350/pjmhs20221611224.

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Objective: To determine the frequency of acute kidney injury in patients presenting with acute ST elevation myocardial infarction and to compare the frequency of in-hospital mortality between patients presenting with acute ST elevation myocardial infarction with versus without acute kidney injury at a tertiary care hospital. Design: It was a descriptive case series. Study Settings: Department of Cardiology, Shaikh Zayed Hospital Lahore-Pakistan over a period of 6 months from January 2021 to June 2021. Material and Methods: A total of 128 patients of both genders aged between 18-70 years presen

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Chen, Xiaobao, Jiang Wei, Ruoyun Xie, and Huaiying Zheng. "Intravesical gemcitabine and docetaxel combined with intravenous tislelizumab as a durable strategy for high-risk non–muscle-invasive bladder cancer." Journal of Clinical Oncology 43, no. 5_suppl (2025): 703. https://doi.org/10.1200/jco.2025.43.5_suppl.703.

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703 Background: For decades, intravesical Bacillus Calmette-Guérin (BCG) has been the standard treatment for high-risk non-muscle-invasive bladder cancer (HR NMIBC). However, its poor tolerability and limited availability underscore the urgent need for more effective therapies. Intravesical sequential gemcitabine and docetaxel (GemDoce) has demonstrated efficacy in HR NMIBC, and immune checkpoint inhibitors (ICIs) have shown effectiveness as second-line therapy for patients with BCG-unresponsive NMIBC. Nevertheless, the combination of immunotherapy with intravesical GemDoce has not yet been re

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Leis, Jose F., Abby Newton, Mary T. Post, Brandon M. Hayes-Lattin, Richard Thomas Maziarz, and Randy A. Taplitz. "Vancomycin-Resistant Enterococcus (VRE) Colonization Is Associated with a High Rate of Bacteremia and Early Mortality in Transplant/Leukemia Patients." Blood 108, no. 11 (2006): 5315. http://dx.doi.org/10.1182/blood.v108.11.5315.5315.

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Abstract Background: Vancomycin-resistant enterococci (VRE) have become increasingly important nosocomial pathogens in very ill and immunocompromised hospitalized patients (pts). Due to an increase in VRE clinical cultures including bacteremias on our institutional transplant/leukemia service in early 2004, active surveillance for VRE among this population was instituted in June 2004. We describe here the incidence and prevalence of VRE colonization and infection in this population over a two year study period, as well as selected pt demographics and mortality associated with VRE bacteremia. M

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Alsuhaibani, Khalid, Amal Hejab, Syed Osman Ahmed, et al. "Non-Western Real-World Experience of Axi-Cel CAR-T in Refractory/Relapsed B-Cell Lymphoma from a Tertiary Center in Saudi Arabia." Blood 144, Supplement 1 (2024): 7824. https://doi.org/10.1182/blood-2024-203769.

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The access to Anti CD-19 CAR-T cell in the treatment of malignancies increased over the past years. Thus, the need to bring real-world evidence on the efficacy and toxicity of this important treatment modality increases, especially from ethnicities who are likely to be under-represented in registrational clinical trials. This is the first report of Axi-cel outcomes from Saudi Arabia. We retrospectively looked at the data of the first 50 patients who were treated with Axi-cel during the period between February 2023 to April 2024 in King Faisal Specialist Hospital and Research Center, Riyadh, SA

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Huang, Ta-Chen, Jhe-Cyuan Guo, Chia-Chi Lin, et al. "Neoadjuvant nivolumab plus paclitaxel/cisplatin- chemo-radiotherapy (neo-NTP-CRT) followed by esophagectomy for locally advanced esophageal squamous cell carcinoma (ESCC): A phase II study." Journal of Clinical Oncology 42, no. 16_suppl (2024): e16098-e16098. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e16098.

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e16098 Background: Adjuvant nivolumab has shown efficacy in reducing recurrence in patients (pts) with locoregional esophageal cancer harboring pathologic residual disease following neoadjuvant chemoradiotherapy (CRT). However, the efficacy of adding nivolumab to neoadjuvant CRT remains unclear. Methods: We conducted a phase II trial of neoadjuvant nivolumab (240mg IV on D-14, 1, 15, 29), paclitaxel (50mg/m2 IV on D1, 8, 15, 22, 29), cisplatin (30mg/m2 IV on D1, 8, 15, 22, 29) and RT (45Gy given in 25 fractions) followed by esophagectomy 6 to 8 weeks after finishing CRT in pts with locally adv

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Demir, Tarik, Young Kwang Chae, Chitaru Kurihara, et al. "Abstract CT211: Double lung transplantation in patients with recent history of malignancy." Cancer Research 85, no. 8_Supplement_2 (2025): CT211. https://doi.org/10.1158/1538-7445.am2025-ct211.

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Abstract Background: Having a recent history of cancer has often been considered a contraindication for double lung transplantation (DLT) due to concerns about the potential for cancer recurrence and poor outcomes. However, the relationship between recent cancer history and mortality following lung transplantation is still unclear. Methods: This study encompassed ll patients who received DLT at a single institution between September 2021 and January 2025 and presented with a recent history of other cancers. All patients were enrolled in cohort C of the DLT registry aimed for lung-limited malig

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Iles, Sihem, Alice Mero, Pablo Bartolucci, et al. "Very Premature Bioprosthetic and Valve Repair Degeneration in Sickle Cell Disease Patients." Blood 144, Supplement 1 (2024): 3892. https://doi.org/10.1182/blood-2024-209304.

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Background: Cardiovascular impairment is a leading cause of premature mortality in patients with sickle cell disease (SCD). Valvular heart disease frequently affects SCD patients, yet data addressing underlying etiologies and management strategies are limited. Although previous study suggested that open-heart surgery could be performed on SCD patients with acceptable risk (PMID: 20026775), it involved a small number of patients and a short follow-up period. Long-term outcomes following valvular heart surgery in SCD patients remain largely unknown. While bioprosthetic valves typically degenerat

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Gugliotta, Gabriele, Fausto Castagnetti, Massimo Breccia, et al. "Five-Year Outcome of 215 Newly Diagnosed Chronic Myeloid Leukemia Patients Treated Frontline with Nilotinib-Based Regimens: A Gimema CML Working Party Analysis." Blood 124, no. 21 (2014): 3141. http://dx.doi.org/10.1182/blood.v124.21.3141.3141.

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Abstract Background. Nilotinib (NIL) is a potent and selective BCR-ABL inhibitor approved for the frontline treatment of chronic myeloid leukemia (CML) based on the results of the ENESTnd study. The sustained superiority of NIL vs. imatinib (IM) was confirmed after 5 years of follow-up (Hughes et al, abs. 677, EHA 2014). However, few data are available on patients (pts) treated frontline with NIL outside of Company-initiated trials. Objectives. To analyze the long-term outcome in a large, independent cohort of newly diagnosed CML pts treated frontline with NIL-based regimens. Methods. We analy

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Holstein, Rachel, Fatima S. Dawood, Pam Daily Kirley, et al. "128. Characteristics and Outcomes of Pregnant Women Hospitalized with Influenza in the United States, Flusurv-net, 2010–2019." Open Forum Infectious Diseases 7, Supplement_1 (2020): S193—S194. http://dx.doi.org/10.1093/ofid/ofaa439.438.

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Abstract Background Pregnant women are at high-risk for influenza-associated hospitalization. We used data from the U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET) to characterize pregnant women hospitalized with influenza. Methods We included pregnant women (15–44 years) residing within a FluSurv-NET catchment area and hospitalized with laboratory-confirmed influenza between October 1 and April 30, during the 2010–19 influenza seasons. Clinical data were obtained on cases through medical chart abstraction. We examined trends in vaccination coverage and antiviral treatment us

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Syed Abd Kadir, Sharifah Shahnaz, Lau Ngee Siang, Guan Yong Khee, et al. "Single Asian Centre Experience in Acute Myeloid Leukaemia with Translocation 8;21 [t(8;21) (q22;q22)/RUNX1-RUNX1T1]." Blood 126, no. 23 (2015): 4950. http://dx.doi.org/10.1182/blood.v126.23.4950.4950.

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Abstract Acute myeloid leukemia (AML) is associated with various acquired genetic changes in hematopoietic progenitor cells. Core binding factor (CBF) AML which consists of AML with t(8;21)(q22;q22)/RUNX1-RUNXT1 and inversion 16 are identified in 13-15% of patients with de novo AML. In both subtypes, the cytogenetic rearrangements disrupt genes that encode subunit of core-binding factor, a transcription factor that is essential in regulating normal hematopoeisis. AML t(8;21) tend to occur in younger age group and display favorable prognosis with chances of attaining complete remission up to 80

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Mishra, Kundan, Suman Kumar, Sandeep Ninawe, et al. "The clinical profile, management, and outcome of febrile neutropenia in acute myeloid leukemia from resource constraint settings." Therapeutic Advances in Infectious Disease 8 (January 2021): 204993612110365. http://dx.doi.org/10.1177/20499361211036592.

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Introduction: Acute myeloid leukemia (AML) is the commonest leukemia in adults. Mortality in thew first 30-days ranges from 6% to 43%, while infections account for 30–66% of early deaths. We aim to present our experience of infections in newly-diagnosed AML. Method: This prospective, observational study, was undertaken at a tertiary care hospital in Northern India. Patients with confirmed AML (bone marrow morphology and flow cytometry) and who had developed febrile neutropenia (FN), were included. Result: A total of fifty-five patients were included in the study. The median age of the patients

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Landry, Carmen, Jon Dorling, Ketan Kulkarni, et al. "Risk Factors for Iron Deficiency in Very Preterm Infants at 4-6 Months Corrected Age." Blood 136, Supplement 1 (2020): 28. http://dx.doi.org/10.1182/blood-2020-142442.

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Background: Iron is an essential micronutrient, especially in infants and young children and is required for erythropoiesis and development of the central nervous system. However, iron deficiency (ID) is the most common micronutrient deficiency worldwide. ID and iron deficiency anemia (IDA) have been associated with poor neurodevelopmental and behavioural outcomes later in life. Preterm infants are particularly at risk of developing ID in early life due to lower iron stores at birth, accelerated growth in the first weeks of life and multiple phlebotomies while in hospital. Therefore, internati

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Greco, Christian S., Mohammad Mahdee Sobhanie, Kelci E. Coe, Courtney Hebert, and Margaret Williams. "600. The Effect of Medication-Assisted Treatment on Completion Rates of Outpatient Parenteral Antibiotic Therapy." Open Forum Infectious Diseases 8, Supplement_1 (2021): S403. http://dx.doi.org/10.1093/ofid/ofab466.798.

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Abstract Background Injection drug use is a nationwide epidemic associated with an increased risk of invasive Staphylococcus aureus (S. aureus) infections. Medication-assisted treatment (MAT) is effective in reducing substance use and increasing adherence to inpatient medical therapy in persons with injection drug use (PWID). Studies assessing the impact MAT has on completion of outpatient parenteral antibiotic therapy (OPAT) are limited. Methods This was a single-center, retrospective, cohort study at The Ohio State University Wexner Medical Center in patients admitted from 12/1/2017 to 12/1/

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Solomon, Lawrence R. "Management of Pain Due to Vaso-Occlusive Crisis (VOC) in Adults with Sickle Cell Disease (SCD) in the Post-Guideline Era: A Retrospective Study in an Urban Medical Center Emergency Department (ED)." Blood 110, no. 11 (2007): 2267. http://dx.doi.org/10.1182/blood.v110.11.2267.2267.

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Abstract Guidelines for managing pain due to VOC published in the United States in 1999 and in England in 2003 suggest prompt initiation of parenteral opioids (within 30 min of arrival); use of an adequate opioid starting dose (5–10 mg or 0.1 mg/kg of morphine intravenously); frequent opioid administration (every 15–30 min) with dose titration if pain is not improved; and individualization of treatment based on the patient’s prior opioid response history. The impact of these guidelines on actual practices has not been assessed however. Thus, the treatment of adults with uncomplicated VOC at a

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Sheu, Michael, Ali Mushtaq, Sofia Molina Garcia, et al. "Infectious Risk in Multiple Myeloma Patients Undergoing Treatment with Teclistamab." Blood 144, Supplement 1 (2024): 1959. https://doi.org/10.1182/blood-2024-194386.

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Introduction Bispecific antibodies (BsAbs) have become a key component of treatment in relapsed/refractory multiple myeloma (MM). However, despite promising response rates demonstrated in clinical trials, BsAbs have been shown to have a distinct adverse event profile including increased risk of infections as compared with conventional treatment regimens. The aim of this study was to explore the infectious risk of MM patients on active treatment with Teclistamab. Methods This was a retrospective study of MM patients treated with Teclistamab at Taussig Cancer Center from December 16th 2022 to Ma

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Dr., Jyosthna B.V, Senthil Narayan Dr., Pandian P. Dr., Malaidevan E. Dr., and Malainesan E. Dr. "A Prospective Randomized Study of Laser Hemorrhoidectomy and Open Hemorrhoidectomy in Patients with Grade III and Grade IV Hemorrhoids." International Journal of Innovative Science and Research Technology 8, no. 3 (2023): 2118–24. https://doi.org/10.5281/zenodo.7811101.

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To compare the outcomes of Laser Hemorrhoidectomy and Open Hemorrhoidectomy.  Objectives: To compare Operating time, postoperative complications like pain, bleeding, wound infection, and hospital stay length.  Materials and Methods:  Study Design: A prospective randomised controlled study. Over the course of two years, 80 patients are studied. Simple randomization divides the study population into two groups. Patients in Group A had laser hemorrhoidectomy, while patients in Group B had open hemorrhoidectomy. The visual analogue scale is used to compare postoperative pain in both groups. The

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Kyvsgaard, Emil Ramsø, Anna Caroline Hasselbalch Riley, Michael Roost Clausen, et al. "Low Mortality from COVID-19 Infection in Patients with B-Cell Lymphoma after Bispecific CD20xCD3 Therapy." Blood 142, Supplement 1 (2023): 4501. http://dx.doi.org/10.1182/blood-2023-178321.

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Introduction: Patients with hematological malignancies are at an increased risk of morbidity and mortality after COVID-19 infection.Especially patients treated with chimeric antigen receptor T-cell (CAR-T) therapy for B-cell malignancies have shown poor outcomes after COVID-19, resulting in reported COVID-19 attributable mortality rates between 41%-50%.Outcomes after COVID-19 infection in patients treated with CD20xCD3 bispecific antibodies have not been reported. We investigated the impact and clinical course of COVID-19 in 130 Danish patients with B-NHL who have received bispecific antibodie

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Albanyan, Omar, Hyejeong Jang, Seongho Kim, et al. "Outcome of Severe Aplastic Anemia Post Allogenic Stem Cell Transplant with Mycophenolate and Calcineurin Inhibitor for Graft Versus Host Disease Prophylaxis." Blood 138, Supplement 1 (2021): 4879. http://dx.doi.org/10.1182/blood-2021-144995.

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Abstract Introduction: Severe aplastic anemia (SAA) is a rare hematopoietic stem cell disorder characterized by hypocellular marrow and pancytopenia. Multiple factors play an important role in treatment approach include age, comorbidities, degree of pancytopenia and availability of stem cell donor to either immunosuppression irrespective (IST) or allogenic hematopoietic stem cell transplant (alloSCT). The use of nonmyeloablative conditioning regimen has improved the outcomes, however the choice for post-transplant GVHD prophylaxis remain a topic of debate. The use of mycophenolate mofetil (MMF

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Zektser, Miri, Katrina Hueniken, Michael Crump, et al. "Considering Older Patients As Candidates for Auto Stem Cell Transplants: A Comprehensive Study on Toxicities and Survival Analysis." Blood 142, Supplement 1 (2023): 4964. http://dx.doi.org/10.1182/blood-2023-174816.

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Introduction: High-dose chemotherapy and autologous stem cell transplantation (ASCT) are commonly used for relapsed/refractory (R/R) Hodgkin (HL) and non-Hodgkin lymphoma (NHL). However, concerns about treatment-related mortality (TRM) and toxicity limit its use in older patients (pts). Existing evidence suggests higher rates of complications and inferior overall survival (OS) in older pts, but conflicting findings suggest that outcomes may be influenced by comorbidities rather than age ( Lahoud O, Curr Oncol Rep. 2015). Our study comparing ASCT outcomes and toxicities in lymphoma pts in young

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Ombada, Mulham, Kenneth Ramos, Maria Bonilla, Michael Sandhu, Ghansham Ghelani, and Teresa Gentile. "Struck By Tsunami: Difficult Case of a Severe Refractory ITP." Blood 144, Supplement 1 (2024): 5458. https://doi.org/10.1182/blood-2024-194758.

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Introduction Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a decreased platelet count and an increased risk of bleeding. While the majority of cases present with mild to moderate thrombocytopenia, severe cases can pose significant challenges in diagnosis and management. We present the case of a 65-year-old male with severe ITP refractory to initial standard treatment including steroids and intravenous immunoglobulin (IVIG) requiring further management including rituximab, romiplostim, Fostamatinib, romiplostim, Efgartigimoid alfa-fcab , eltrombopag and partia

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Harris, Odette A., Carrie R. Muh, Monique C. Surles, et al. "Discrete cerebral hypothermia in the management of traumatic brain injury: a randomized controlled trial." Journal of Neurosurgery 110, no. 6 (2009): 1256–64. http://dx.doi.org/10.3171/2009.1.jns081320.

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Object Hypothermia has been extensively evaluated in the management of traumatic brain injury (TBI), but no consensus as to its effectiveness has yet been reached. Explanatory hypotheses include a possible confounding effect of the neuroprotective benefits by adverse systemic effects. To minimize the systemic effects, the authors evaluated a selective cerebral cooling system, the CoolSystem Discrete Cerebral Hypothermia System (a “cooling cap”), in the management of TBI. Methods A prospective randomized controlled clinical trial was conducted at Grady Memorial Hospital, a Level I trauma center

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Chiu, May, Samuel Hague, and Henry Chan. "Efficacy and Tolerability of Gemcitabine-Based Chemotherapy in Relapsed/Refractory Lymphoma Patients Not Eligible for Stem Cell Transplant." Blood 138, Supplement 1 (2021): 4566. http://dx.doi.org/10.1182/blood-2021-149810.

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Abstract Introduction: Gemcitabine, Dexamethasone, and Cisplatin or Carboplatin (GDP/GDCarboP) regimen has comparable efficacy to other salvage therapy in relapsed/refractory (R/R) aggressive lymphoma with successful stem cell mobilisation and bridge to autologous stem cell transplant (ASCT)(Crump et al. 2004). However, half of the patients will not be eligible for ASCT due to inadequate treatment response or co-morbidities. To date, there is little data on the efficacy of Gemcitabine-based salvage regimen in transplant-ineligible patients. Here, we present the real-life data on the outcome of

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Zhao, Yubing, Zhanyun Liu, Yang Shen, Jiong Hu, Junmin Li, and Hongming Zhu. "Arsenic Trioxide Combined with Mannitol for the Treatment of Central Nervous System Relapse in Acute Promyelocytic Leukemia Patients：a Retrospective Study." Blood 144, Supplement 1 (2024): 6064. https://doi.org/10.1182/blood-2024-200772.

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Background: Acute promyelocytic leukemia (APL) has achieved significant advances in curability in recent years; however, central nervous system (CNS) relapse remains a critical concern affecting 3-5% of APL patients. In this context, we propose a treatment regimen incorporating arsenic trioxide (ATO) and intravenous mannitol, demonstrating promising efficacy. Methods: From 2013 to 2023, a total of 26 APL patients with CNS relapse were enrolled from Ruijin Hospital and Beizhan Hospital, Shanghai, China. Myeloid blasts were detected by flow cytometry in all patients' cerebrospinal fluid (CSF). T

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De las Fuentes-Cepeda, Alejandra, Perla R. Colunga-Pedraza, Héctor Alejandro Vaquera Alfaro, et al. "Outpatient Care Dynamics after Allogeneic Transplantation: Reasons for Hospitalization and Early Mortality in a Latin American Transplant Center." Blood 144, Supplement 1 (2024): 7299. https://doi.org/10.1182/blood-2024-210921.

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Background: The outpatient model in the practice of hematopoietic stem cell transplantation (HSCT) has been accepted for its positive results in terms of effectiveness and safety. Its main advantages include shorter hospital stays, lower risk of infections, and higher patient satisfaction. However, there are associated risks, such as increased potential for rapid disease progression without immediate medical intervention, difficulties in managing severe complications, and the challenge of ensuring adequate patient and caregiver education to recognize early signs of complications. In developing

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Khorsand, Nakisa, Reinier M. van Hest, Shakiba Zahedin Labbaf, et al. "Clinical Outcome After Occurrence Of Vitamin K-Antagonist Related Major Bleeding Complication: A Two-Year Observational Follow-Up Study." Blood 122, no. 21 (2013): 2382. http://dx.doi.org/10.1182/blood.v122.21.2382.2382.

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Abstract History of major bleed during vitamin K-antagonist (VKA) therapy is an important predictor for future major bleeds. However, these patients do have an increased risk for thromboembolic events (TE) due to the underlying disease, and clinicians face a dilemma whether or not to continue VKA after major bleeding. We aim to present here long term follow-up (FU) of VKA patients after occurrence of a major bleeding complication, to increase knowledge of the clinical outcome and the consequences of (dis)continuation of VKA in this specific patient population. Consecutive patients who presente

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Hurst, Jonathan B., and Richard Gentry Wilkerson. "Impact of an Infusion Center on the Utilization of Hospital Based Care in Sickle Cell Disease." Blood 136, Supplement 1 (2020): 6–7. http://dx.doi.org/10.1182/blood-2020-143016.

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Background: Sickle cell disease (SCD) consists of a group of hemoglobinopathies inherited in an autosomal recessive pattern whereby a single point mutation results in the formation of a hemoglobin protein with altered structure. Many of the complications of SCD and their end organ manifestations are the result of a vaso-occlusive process. These include acute chest syndrome, dactylitis, myocardial infarction, stroke, venous thromboemboli, avascular necrosis, and acute vaso-occlusive episodes (VOEs). VOEs are the most common reason for a patient with SCD to seek medical attention. This care is o

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Pandya, Shivani, Zoe Clancy, Sulena Shrestha, Li Wang, and Onur Baser. "Burden of CRAB Events By Relapse in Patients with Newly Diagnosed Multiple Myeloma Not Eligible for Stem Cell Transplant." Blood 132, Supplement 1 (2018): 4770. http://dx.doi.org/10.1182/blood-2018-99-111236.

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Abstract Background: For decades, CRAB criteria (hypercalcemia, renal impairment, anemia, and bone disease) have been used to diagnose multiple myeloma (MM), but little is known about the economic burden of CRAB in patients with MM who have relapsed. The only category 1 doublet regimens recommended by NCCN Guidelines for non-transplant candidates are lenalidomide-based (NCCN Myeloma v4.2018). This study aims to evaluate CRAB event rates and the associated economic burden among newly diagnosed MM (NDMM) patients on doublet therapy who were not eligible for stem cell transplant (SCT) and were fo

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Jiménez-Soto, Rodolfo, Mercedes Aguilar-Soto, and Roberta Demichelis. "The Impact of Different Prophylactic Anticoagulation Doses on the Outcomes of Patients with COVID-19." Blood 136, Supplement 1 (2020): 17. http://dx.doi.org/10.1182/blood-2020-142594.

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Introduction As the COVID-19 pandemic spread throughout the world, it was seen that patients who presented with critical disease had a higher incidence of thrombotic complications, associated with a poor prognosis. Currently prophylactic anticoagulation is recommended for all patients with COVID-19 who require hospitalization as part of the supportive management. However, since a higher incidence of thrombosis despite prophylactic anticoagulation has been reported, some recommendations indicate that an increase to intermediate or therapeutic dosing should be considered. The full spectrum of co

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Gorfinkel, Lev, Erica B. Esrick, Alexander Lake, et al. "Gene Therapy for Sickle Cell Disease Is Associated with a Decreased Transplant Length of Stay and Similar Rates of Short-Term Complications Compared to Allogeneic Matched Sibling Stem Cell Transplant: A Single Center Experience." Blood 144, Supplement 1 (2024): 3574. https://doi.org/10.1182/blood-2024-198677.

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Background: Myeloablative allogeneic hematopoietic cell transplant (alloHCT) with a matched sibling donor (MSD) remains the standard curative treatment approach for young patients with sickle cell disease (SCD). However, adolescent and young adult patients undergoing MSD alloHCT or patients undergoing alterative donor alloHCT experience increased transplant related morbidity/mortality and increased risk for chronic graft-versus-host disease (GVHD). With the 2023 FDA approval of two gene therapy (GT) products for patients ≥12y with a history of vaso-occlusive events (VOEs), patients for whom al

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1Dr., Saikrishna Rengerla 2Dr. Akhil Lohkare 3Dr. CM Badole. "FUNCTIONAL OUTCOME OF BIPOLAR HEMIARTHROPLASTY IN DISPLACED INTRACAPSULAR FEMORAL NECK FRACTURE IN ELDERLY IN RURAL TERTIARY HOSPITAL." International Journal of Medical Science in Clinical Research and Review 05, no. 05 (2022): 609–18. https://doi.org/10.5281/zenodo.7100486.

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Original Research Paper FUNCTIONAL OUTCOME OF BIPOLAR HEMIARTHROPLASTY IN DISPLACED INTRACAPSULAR FEMORAL NECK FRACTURE IN ELDERLY IN RURAL TERTIARY HOSPITAL <strong>Authors:</strong> <strong><sup>1</sup></strong><strong>Dr. Saikrishna Rengerla</strong><strong>, </strong><strong><sup>2</sup></strong><strong>Dr. Akhil Lohkare, <sup>3</sup>Dr. CM Badole</strong> <em><sup>1,2</sup></em><em>Senior Resident, Dept of Orthopaedics, MGIMS Sevagram</em> <em><sup>3</sup></em><em>Director-Professor & HOD, Dept of Orthopaedics, MGIMS Sevagram</em> Corresponding Author: Dr. Saikrishna Rengerla, Dept of

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Fahmi H. Kakamad, Harem K. Ahmed, Ali H. Hasan, et al. "Chest Wall Hydatid Cysts: A Systematic Review." Barw Medical Journal 3, no. 3 (2025): 34–45. https://doi.org/10.58742/bmj.v3i3.185.

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Abstract Introduction Given the rarity of chest wall hydatid disease, information on this condition is primarily drawn from case reports. Hence, this study systematically reviews the disease's manifestation and management. Methods Google Scholar was searched with the following keywords: (hydatid OR hydatidosis OR tapeworms OR echinococcosis OR echinococcus OR granulosus AND chest OR wall OR thoracic OR thorax OR rib OR sternum OR sternal OR cartilage OR intercostal OR extra-pulmonary). Inclusion criteria involved a confirmed diagnosis of chest wall hydatid cyst. Only English-language studies p

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Sharma, Santosh Kumar. "Failed Nerve Blocks: Prevention and Management." Journal of Anaesthesia and Critical Care Reports 4, no. 3 (2018): 3–6. http://dx.doi.org/10.13107/jaccr.2018.v04i03.101.

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“The secret of success is constancy of purpose” – Benjamin Disraeli, British politician Success and failure go side by side in regional anesthesia. No anesthesiologist can claim a 100% success record while giving nerve blocks. Hence, it is always better to focus on how to prevent causes of block failure rather than focusing on managing a failed block. Abdallah and Brull did a comprehensive literature hunt to find out the meaning of block “success” which were used by various authors in their studies and found that it was highly variable and there was lack of consensus regarding its meaning [1].

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Hazem, El-Akabawy, Omer Emad, Mowafy Hossam, Nessim Iris, and Maghraby Ahmed. "Clinical Evaluation of plasma Gelsolin as a novel marker for sepsis: comparison with Procalcitonin regarding early diagnosis and prognosis in septic patients." Biolife 5, no. 4 (2022): 416–27. https://doi.org/10.5281/zenodo.7371656.

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<strong>ABSTRACT</strong> Gelsolin is an actin-binding plasma protein that is part of an 'actin-scavenging' system. Gelsolin serves a protective role against tissue injuries and may play a crucial role in the pathophysiology of sepsis. The present study was designed to evaluate the diagnostic utility and the prognostic value of pGSN in the critically ill septic patients. A total of 80 critically ill septic patients and another 40 critically ill non septic patients were included in this observational prospective randomized study. All patients were subjected to a measurement of pGSN and

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Dr., Piyush Kumar. "What is the impact of Covid-19 on the Antenatal Care Services Utilization in Public-Private-Rural-Urban Hospitals of India during the COVID-19 Pandemic Period of 2020-2021 compared to pre-pandemic era 2018-2019?" MODERN APPLIED MEDICAL RESEARCH ISSN: 2582-9181 2, no. 2 (2022): 1–10. https://doi.org/10.36099/mamr.220522.

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What is the impact of Covid-19 on the Antenatal Care Services Utilization in Public-Private-Rural-Urban Hospitals of India during the COVID-19 Pandemic Period of 2020-2021 compared to pre-pandemic era 2018-2019?    Dr Piyush Kumar<sup>1</sup> <strong><sup>1 M.B.B.S. E.M.O.C., P.G.D.P.H.M., Senior General Medical Officer, Health Department, Government of Bihar, India, </sup></strong><strong><sup>drpiyush003@gmail.com</sup></strong> <strong><sup>Original Research</sup></strong> <strong><sup>Impact of Covid-19 on the Antenatal Care Services Utilization in Public-Private-Rural-Urban

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Bledar, Abdurrahmani. "Compensation of Political Convicts in Albania as a Challenge to the Rule of Law and Human Rights." Beder Journal of Educational Sciences Volume 26(2) (June 21, 2023): 124–56. https://doi.org/10.5281/zenodo.8064626.

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  <strong>Abstract</strong> The change in the political and legal system in Albania gave birth to great hope, not only for the triumph of dignity but also for the correction of injustices towards former political prisoners. In Albania, from 1991 to 2008, a series of legal measures addressed the issue of former political prisoners. Their purpose was not only to legally consider punishment for crimes of a political nature as unjust but also to award compensation. But, in the span of 17 years, they remained a formal statement on paper, an inadequate legal solution that in very few cases beca

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Bledar, Abdurrahmani. "Compensation of Political Convicts in Albania as a Challenge to the Rule of Law and Human Rights." Beder Journal of Educational Sciences Volume 26, no. 2 (2023): 126. https://doi.org/10.5281/zenodo.8070078.

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<strong>Abstract</strong> The change in the political and legal system in Albania gave birth to great hope, not only for the triumph of dignity but also for the correction of injustices towards former political prisoners. In Albania, from 1991 to 2008, a series of legal measures addressed the issue of former political prisoners. Their purpose was not only to legally consider punishment for crimes of a political nature as unjust but also to award compensation. But, in the span of 17 years, they remained a formal statement on paper, an inadequate legal solution that in very few cases became effe

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Khawaja, Zeeshan. "HPB P56 Outcomes of laparoscopic versus percutaneous cholecystostomy in high-risk patients with acute calculus cholecystitis." British Journal of Surgery 109, Supplement_9 (2022). http://dx.doi.org/10.1093/bjs/znac404.151.

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Abstract Background Around 10–15% population in the UK have gallstones. (1) Gall stone related disease account for 1/3rd of the emergency surgical admissions and referrals. (2) Acute cholecystitis, which is the inflammation of the gall bladder can develop in 1–3% of these patients. (3) Without treatment, acute cholecystitis may resolve spontaneously within 1–7 days. However, 25–30% of people will require surgery or develop complications. (4) Laparoscopic cholecystectomy is the standard technique for management of acute cholecystitis. However, in the patients who are high risk, LC can result in

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Abdullahi, Lawal B., Mohammad A. Mohammad, Lofty-John C. Anyanwu, Mohammad S. Aliyu, and Bilya I. Liman. "Outcome of intussusception among children in Kano." Pyramid Journal of Medicine 4, no. 1 (2021). http://dx.doi.org/10.4081/pjm.2021.104.

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Intussusception is defined as the telescoping of a segment of the gastrointestinal tract within the lumen of the adjacent segment usually proximal to distal. It is a common cause of intestinal obstruction in children, rarely it can occur in adult. This condition is reported in both developed and developing countries, however there are few publications in Nigeria about the incidence, presentation and outcome of its management, most especially in children. This is a prospective study of pediatric patients managed in single center Kano over a period of 18months. The demographic data, clinical fea

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Kumar N, Pavan, C. Sai Manoj Kumar, and Murthy Kumar V. "COMPARATIVE STUDY OF EARLY VERSUS DELAYED LAPAROSCOPIC CHOLECYSTECTOMY IN ACUTE CHOLECYSTITIS AND ITS COMPLICATIONS." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, June 1, 2025, 8–10. https://doi.org/10.36106/ijsr/8700378.

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Background: Acute cholecystitis is due to gallstones in upto 90% of patients. Laparoscopic cholecystectomy is currently the gold standard treatment for acute cholecystitis and are mainly performed after the acute episode occurs while conservative therapy followed by delayed laparoscopic cholecystectomy are still common in many centres. However the timing of laparoscopic cholecystectomy still remains controversial regarding the inflammation, edema and adhesions during the course of disease. Aim: This study aimed to assess the benefits and complications associated with early laparoscopic cholecy

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