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Rozprawy doktorskie na temat „Whooping”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 1 lutego 2022

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1

Hassan, H., Gayatri Jaishankar, and Demetrio Macariola. "The "Non" Whooping Cough." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/8861.

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Torvaldsen, Siranda. "The epidemiology and prevention of pertussis in Australia." University of Sydney. Paediatrics and Child Health, 2001. http://hdl.handle.net/2123/808.

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Pertussis (whooping cough) remains an important public health problem in Australia. Although mortality and morbidity from pertussis declined dramatically following the introduction of mass vaccination programs in 1953, the level of morbidity remains unacceptably high for a vaccine-preventable disease. Aims and methods The primary aims of this thesis were (i) to ascertain the epidemiology of pertussis in Australia between 1993 and 2000 by analysing and interpreting sources of routinely collected data on pertussis; and (ii) to examine the effectiveness of vaccination against pertussis in a

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3

Piyawong, Wirawan. "Spatio-temporal numerical modelling of whooping cough dynamics." Thesis, Brunel University, 2001. http://bura.brunel.ac.uk/handle/2438/6626.

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The SIR (Susceptible/Infectious/Recovered) whooping cough model involving nonlinear ordinary differential equations is studied and extended to incorporate (i) diffusion (ii) convection and (iii) diffusion-convection in one-space dimension. Firstand second-order finite-difference methods are developed to obtained the numerical solutions of the ordinary differential equations. Though implicit in nature, with the resulting improvements in stability, the methods are applied explicitly. The proposed methods are economical and reliable in comparison to classical numerical methods. When extended to t

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4

Johnston, I. D. A. "The current severity and longterm sequelae of whooping cough." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605661.

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Cheung, Yung-yan Terence. "Whooping cough : are we seeing the reemergence of the infection in Hong Kong? /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/b39724049.

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McKenna, Philip Rood. "Winging it : a bold step toward the whooping crane's return." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/39445.

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Thesis (S.M. in Science Writing)--Massachusetts Institute of Technology, Dept. of Humanities, Graduate Program in Science Writing, 2006.<br>Includes bibliographical references (leaves 41-42).<br>Since the fall of 2001, biologists have taught endangered whooping cranes how to migrate over a once-lost course stretching from the wetlands of central Wisconsin to the mud flats of Florida's Gulf Coast. Wildlife biologists did this through an unusual method of reintroduction: training the endangered birds to follow behind ultralight airplanes for the entire 1,200-mile journey. The technique is highly

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7

Gil, de Weir Karine. "Whooping crane (Grus americana) demography and environmental factors in a population growth simulation model." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3778.

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The Whooping Crane (Grus americana) is among North AmericaÂs most charismatic species. Between 1938 and 2004, the population that migrates between Aransas National Wildlife Refuge (ANWR) and Wood Buffalo National Park (WBNP), grew from 18 to 217 individuals. The recovery plan objective for this endangered species is to downlist the population in 2035, but this requires interpretive assessment of population responses to environmental factors over the long term. I analyzed 27 years of banding data, 37 years of nest monitoring data, and 20 years of winter reports to estimate age-specific mortali

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8

Srikannathasan, Velupillai. "Biochemical and structural analysis of Bordetella pertussis lipopolysaccharide A biosynthetic pathway enzymes." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273576.

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9

Al-Fellah, Giamal Nouri. "Inactivation of Bordetella pertussis by rat lung lavage fluids (LLF)." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263427.

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10

Brotherston, Christopher. "Interaction of Bordetella pertussis adenylate cyclase toxin with target cells." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263429.

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MacDonald-Fyall, Julia. "The protective and immunomodulatory properties of Bordetella pertussis adenylate cyclase toxin." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248267.

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Garrod, Tracey. "Partial purification and characterisation of Bordetella bronchiseptica dermonecrotic toxin." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239514.

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13

Funnell, Simon Gordon Paul. "Mechanisms of colonisation of mammalian tissues by Bordetella pertussis." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239726.

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14

Advani, Abdolreza. "Epidemiological characterisation of Bordatella pertussis in Sweden, 1970-2004 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-052-7/.

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Gorringe, A. R. "The effects of growth conditions on the expression of virulence determinants of Bordetella pertussis." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235294.

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16

Berry, P. R. "Production of monoclonal antibodies to Bordetella pertussis as a means of identifying protective antigens." Thesis, University of Reading, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376819.

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Li, Jing-Li. "A molecular study of virulence factors of Bordetella species." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303193.

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A 1kb HinfI DNA fragment, containing a repeat DNA sequence element was isolated from a Bordetella pertussis BP348 cosmid gene bank. This repeat DNA sequence has subsequently been named IS148. The insertion sequence was demonstrated by have a high copy number only in B.pertissus and to be absent in Bordetella parapertussis and Bordetella bronchiseptica. Using a restriction fragment of IS148 labelled with radioactivity as a probe in DNA or whole cell dot blots between 10-100 cells could be detected or from 100pb-1ng DNA. Furthermore, a pair of oligonucleotide primers was synthesised correspondin

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18

Cheung, Yung-yan Terence, and 張勇仁. "Whooping cough: are we seeing the reemergenceof the infection in Hong Kong?" Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B39724049.

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White, Jennifer L. "Management of captive whooping cranes (Grus americana ) to improve breeding behaviour and success." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0029/MQ66980.pdf.

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Pillay, Victoria. "A systematic review of the symptomatic treatment of the cough in whooping cough." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/8789.

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Includes bibliographical references.<br>Background: There are between 20 - 40 million cases of whooping cough annually world-wide, 90% of which occur in developing countries, resulting in an estimated 200 - 300 O00 fatalities each year. Much of the morbidity is due to the paroxysmal cough. Corticosteroids, salbutamol (a β₂- adrenergic stimulant), and pertussis-speciﬁc immunoglobulin have been proposed as standard treatment for the cough. Antihistamines have also been administered. No systematic review of the effectiveness of any of these interventions or others has been performed. Objective: i

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21

Sidey, Fiona M. "Metabolic effects of Bordetella pertussis." Thesis, University of Strathclyde, 1987. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=20352.

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The present work confirmed that B. pertussis infection or pertussis toxin produce hypoglycaemia in mice. The hypoglycaemia was associated with hyperinsulinaemia, and both were abolished by destruction of the pancreatic β cells with alloxan. Impaired glucose counterregulatory mechanisms may also contribute to pertussis-induced hypoglycaemia, as the hypoglycaemic action of insulin was prolonged in pertussis infected mice. On the other hand, impaired responsiveness to lower doses of insulin was found. Pertussis-induced hyperinsulinaemia had two components. First, the increase in serum insulin in

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22

Khan, Farhat Mirza. "Effects of toxoiding agents on protective antigens of Bordetella pertussis and on other proteins." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360122.

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23

Lund, Sarah Jane. "Virulence of Bordetella parapertussis : a comparison of ovine and human isolates." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314103.

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24

Phillips, Linda Jane. "Immunization against Bordetella pertussis." Thesis, Kansas State University, 1985. http://hdl.handle.net/2097/9871.

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25

Fry, Scott Robert. "The development and evaluation of DNA vaccines against whooping cough using a murine respiratory model of infection." University of Southern Queensland, Faculty of Sciences, 2006. http://eprints.usq.edu.au/archive/00004787/.

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In this study, a suite of single antigen DNA vaccines, combination DNA vaccines and dual modality vaccines, were developed and evaluated for their potential to induce humoral and cell-mediated immune responses, and protective efficacy against Bordetella pertussis, the aetiological agent of whooping cough, using the mouse respiratory challenge model.

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26

Cahill, Edward Sean. "Antigen delivery systems for nasal immunisation against B. pertussis." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321455.

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Castillo, María Esther, Carlos Bada, Aguila Olguita Del, Helasvuo Verónica Petrozzi, Ore Verónica Casabona, Isabel Reyes, and Valle Mendoza Juana Mercedes Del. "Detection of Bordetella pertussis using a PCR test in infants younger 3 than one year old hospitalized with whooping cough in five 4 Peruvian hospitals." International Society for Infectious Diseases (Int J Infect Dis), 2015. http://hdl.handle.net/10757/582607.

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Objectives To report the incidence, epidemiology, and clinical features of Bordetella pertussis in Peruvian infants under 1 year old. Patients and methods A prospective cross-sectional study was conducted in five hospitals in Peru from January 2010 to July 2012. A total of 392 infants under 1 year old were admitted with a clinical diagnosis of whooping cough and tested for B. pertussis by PCR. Results The pertussis toxin and IS481 genes were detected in 39.54% (155/392) of the cases. Infants aged less than 3 months were the most affected, with a prevalence of 73.55% (114/155). T

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del, Valle-Mendoza Juana, Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Valle-Vargas Cristina del, Erico Cieza-Mora, Johanna Martins-Luna, Ronald Aquino-Ortega, Andrea Silva-Vásquez, Jorge Bazán-Mayra, and Pablo Weilg. "Bordetella pertussis in children hospitalized with a respiratory infection: clinical characteristics and pathogen detection in household contacts." BioMed Central Ltd, 2018. http://hdl.handle.net/10757/624653.

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Objective: Describe the prevalence of Bordetella pertussis via PCR in children under 5 years old hospitalized as probable cases of pertussis and report the most common clinical features among them. Results: A positive PCR result for B. pertussis was observed in 20.5% of our samples (18/88), one-third of them were from infants between 2 and 3 months old. The most common symptoms were paroxysms of coughing (88.9%), difficulty breathing (72.2%), cyanosis (77.8%) and fever (50%). The mother was the most common symptomatic carrier (27.8%), followed by uncles/aunts (22.2%) among children with pertus

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29

LaFever, Kristin E. "Spatial and temporal winter territory use and behavioral responses of whooping cranes to human activities." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1877.

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J, Lawrence Andrew. "Rapid laboratory diagnosis of Bordetella pertussis infection (whooping cough) using seriological and DNA based detection techniques /." Title page, contents and summary only, 1994. http://web4.library.adelaide.edu.au/theses/09S.M/09s.ml419.pdf.

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Zorzeto, Tatiane Queiroz. "Resposta humoral e celular de lactentes vacinados com pertussis celular total ou modificada pela extração de lipopolissacarideo." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311081.

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Orientador: Maria Marluce dos Santos Vilela<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T01:20:12Z (GMT). No. of bitstreams: 1 Zorzeto_TatianeQueiroz_M.pdf: 1695884 bytes, checksum: 267f0534bc256440762ad9d78bc6402d (MD5) Previous issue date: 2008<br>Resumo: A associação temporal de eventos adversos de variada gravidade à imunização com pertussis celular total (DTP) tem estimulado o desenvolvimento de vacinas antipertussis menos reatogênicas. Este ensaio clínico fase I visou à avaliação da imunogenicidad

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Laverty, Meghan. "Association Between Maternal Pertussis Vaccination During Pregnancy and Early Childhood Health Outcomes." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40084.

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Background: Little is known about whether there are any longer-term adverse health effects in children following Tdap (tetanus, diphtheria, and acellular pertussis) vaccination during pregnancy. Objective: To assess the association between maternal Tdap vaccination during pregnancy and risk of the following early childhood adverse health outcomes: (1) infections (upper and lower respiratory tract infections, gastrointestinal infections, and otitis media), (2) pediatric asthma, (3) neoplasm, (4) vision or hearing loss, and (5) urgent and in-patient health services utilization. Methods:

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Del, Valle Mendoza Juana Mercedes, Oré Veronica Casabona, Helasvuo Veronica Petrozzi, Tapia Angela Cornejo, Pablo Weilg, Maria J. Pons, Mora Erico Cieza, Mayra Jorge Bazán, Pacherres Hernan Cornejo, and Joaquin Ruiz. "Bordetella pertussis diagnosis in children under five years of age in the Regional Hospital of Cajamarca, Northern Peru." The Journal of Infection in Developing Countries (JIDC), 2015. http://hdl.handle.net/10757/605267.

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Introduction: Bordetella pertussis is an important human pathogen that causes whooping cough (pertussis), an endemic illness responsible of significant morbidity and mortality, especially in infants and children. Worldwide, there are an estimated of 16 million cases of pertussis, resulting in about 195,000 child deaths per year. In Peru, pertussis is a major health problem that has been on the increase despite immunization efforts. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age suspected to have whopping cough in Cajamarca

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Black, Andrew James. "The stochastic dynamics of epidemic models." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/the-stochastic-dynamics-of-epidemic-models(196cf4a1-2db2-4696-bc64-64fb28cb0b7d).html.

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This thesis is concerned with quantifying the dynamical role of stochasticity in models of recurrent epidemics. Although the simulation of stochastic models can accurately capture the qualitative epidemic patterns of childhood diseases, there is still considerable discussion concerning the basic mechanisms generating these patterns. The novel aspect of this thesis is the use of analytic methods to quantify the results from simulations. All the models are formulated as continuous time Markov processes, the temporal evolutions of which is described by a master equation. This is expanded in the i

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Williams, Emily G. "Whooping cough among Western Cree and Ojibwa fur-trading communities in subarctic Canada : a mathematical-modeling approach /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1421166.

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Del, Valle-Mendoza Juana, Valle-Vargas Cristina del, Ronald Aquino-Ortega, Valle Luis J. Del, Erico Cieza-Mora, Wilmer Silva-Caso, Jorge Bazán-Mayra, et al. "Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru." Tehran University of Medical Sciences, 2021. http://hdl.handle.net/10757/655868.

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Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, besides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru.<br>Background and Objectives: Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In

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Warren, Andrew Eugene. "The use of inhaled beclomethasone to decrease the duration of paroxysmal coughing in pediatric patients with pertussis : results and methodologic issues in a randomized clinical trial /." St. John's, NF : [s.n.], 1997.

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Hegerle, Nicolas. "Evolution of Bordetella pertussis and Bordetella parapertussis under acellular Pertussis vaccine pressure : What future for whooping cough and Pertussis vaccination ?" Paris 7, 2014. http://www.theses.fr/2014PA077038.

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La coqueluche est une maladie respiratoire dangereuse pour les nouveaux nés non vaccinés. Celle-ci est causée par Bordetella pertussis et Bordetella parapertussis, deux bactéries à gram négatif dont le seul hôte connu est l'homme. L'introduction de la vaccination contre B. Pertussis, le pathogène majoritairement responsable de cette maladie, à grandement impacté l'épidémiologie de la coqueluche ainsi que les populations de B. Pertussis circulant dans la population humaine. Les premier vaccins introduit dans les 1950 et utilisés pour la primo vaccination et le rappel enfant, dit à germes entier

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McMillen, Janet L. "Productivity and movements of the greater sandhill crane population at Seney National Wildlife Refuge: potential for an antroduction of whooping cranes." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1298917399.

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McMillen, Janet L. "Productivity and movements of the greater sandhill crane population at Seney National Wildlife Refuge : potential for an introduction of whooping cranes /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487588939090135.

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Correia, Carolina Argondizo. "Influência da vacinação com dTpa em gestantes no perfil da resposta imunológica contra a Bordetella pertussis na criança." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-18052018-101733/.

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A Bordetella pertussis é a bactéria causadora da coqueluche, doença infectocontagiosa que tem reemergido em diversos países apesar das altas coberturas vacinais. Como os indivíduos mais afetados são crianças menores de seis meses de idade, a vacinação de gestantes com uma dose de vacina adsorvida contra tétano, difteria e coqueluche (B. pertussis acelular - dTpa) foi proposta. O objetivo é promover a transferência de altos títulos de anticorpos maternos ao feto e recémnascido, resultando na sua proteção até que o seu esquema vacinal esteja concluído. Esta estratégia é empregada em diversos paí

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Yilmaz, Cigdem. "Immune Responses Against The Recombinant Fimx And Putative Peptidyl-prolyl Cis-trans Isomerase From Bordetella Pertussis." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613684/index.pdf.

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Whooping cough (pertussis) is a highly contagious respiratory infection caused by Bordetella pertussis. It becomes widespread among adolescent and adults as well as infants. Although availability of effective pertussis vaccines seems to decrease the incidence of the disease, B. pertussis circulation in population has not been eliminated. It is thought that the antigenic drifts in major protective antigens and continued circulation of B. pertussis strains will result in gradual loss of the efficacy of the current pertussis vaccines. Therefore, development of more effective acellular pertussis v

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Dupré, Elian. "La régulation de la virulence chez Bordetella pertussis : BvgS, modèle original de capteur de système à deux composants." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S022/document.

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La virulence de Bordetella pertussis, agent de la coqueluche, est liée à un arsenal de facteurs de virulence dont l’expression est régulée par le système à deux composants BvgAS. BvgA est le régulateur de réponse et BvgS le capteur du système, qui possède 3 domaines putatifs de perception de signaux. Il s’agit de 2 domaines périplasmiques « Venus FlyTrap » (VFT), reliés par un segment transmembranaire à un domaine PAS (Per-ARNT-Sim) cytoplasmique qui fait la jonction avec l’histidine-kinase. Les signaux perçus par ces domaines capteurs sont inconnus, mais une température de 37°C est suffisante

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Wang, Kay Yee. "Mycoplasma pneumoniae and Bordetella pertussis in patients with persistent cough in primary care." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:74b15a97-708d-4927-b0aa-ce802f4af2aa.

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Background: Persistent cough following an acute respiratory tract infection is a challenging and frequently encountered problem in primary care. Mycoplasma pneumoniae (M. pneumoniae) and Bordetella pertussis (pertussis) particularly predispose patients to persistent cough. Whilst the incidence of M. pneumoniae is highest in children, pertussis may also occur in adults. Method: Four studies were conducted for this thesis. First, a systematic review to assess the diagnostic accuracy of symptoms and signs in the clinical recognition of M. pneumoniae. Second, a retrospective analysis of a cohort o

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Galhardo, Cynthia Soares. "Fatores que determinam a produção de IL-12 em macrófagos murinos ativados por Bordetella pertussis e B. parapertussis." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-15052014-101030/.

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Bordetella pertussis e B. parapertussis são agentes etiológicos da coqueluche. A IL-12 liga a imunidade inata e adaptativa. Investigamos alguns mecanismos que controlam a síntese de IL-12 em macrófagos medulares murinos (MfDM) ativados in vitro com estas duas espécies de bactérias. Demonstramos que IL-12p40 e TNF-a foram produzidos pelos MfDM ativados com qualquer uma das bactérias. A síntese de IL-12p40 foi dependente de TNF-a, MyD88 e NFkB e independente de MAPK p38 e ERK 1/2. Durante a estimulação com B. pertussis a produção de IL-12p40 foi dependente de TLR-4, mas com B. parapertussis envo

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Freitas, Angela Carvalho. "Avaliação de novas estratégias vacinais contra a coqueluche no município de São Paulo." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/6/6132/tde-26082008-153502/.

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Introdução: A coqueluche é caracterizada por tosse paroxística, pode levar menores de um ano de idade ao óbito, deixar seqüelas e exacerbar quadros respiratórios crônicos. A imunidade após a doença ou vacina não é para toda a vida. Nos países desenvolvidos, apesar de altas coberturas vacinais e do controle da doença entre as décadas de 50 e 80, desde o final dos anos 80 é observado o aumento dos casos em adolescentes, adultos e lactentes, sendo indicado o reforço vacinal para adolescentes e adultos. No Brasil a doença aparenta estar sob controle, mas há um estudo teórico que demonstra a possib

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Prestes, Ana Fabíola Rollo de Oliveira. "Avaliação de adjuvantes em novas formulações de vacina tríplice bacteriana." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-28042009-111641/.

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As vacinas pertussis celulares apresentam certa reatogenicidade e as acelulares, menos reatogênicas, têm seu uso restrito, devido a seu alto custo. O Instituto Butantan desenvolveu uma vacina pertussis celular (Plow), com baixo teor de lipopolissacarídeo e outra acelular (Pa), por metodologia simples e econômica. Essas preparações, combinadas aos toxóides diftérico e tetânico (DTPlow e DTPa, respectivamente), foram comparadas à DTP tradicional, com diferentes adjuvantes: vitamina A, surfactante pulmonar, BCG, monofosforil lipídeo A (MPL) e Al(OH)3. A resposta humoral em camundongos foi semelha

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Ferronato, Angela Esposito. "Identificação de vírus respiratórios em lactentes internados com suspeita clínica de coqueluche." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-28032018-101026/.

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Introdução: a coqueluche é uma doença causada pela Bordetella pertussis (BP), sendo mais frequente e grave em lactentes menores de um ano de idade. Com a introdução da vacina, houve redução na incidência mundial da doença, porém nos últimos 10 anos observa-se uma recrudescência. Pode apresentar-se de forma menos característica em lactentes, especialmente antes do final do esquema vacinal para o primeiro ano de vida. O quadro clínico, nesses pacientes, pode ser semelhante ao das infecções por vírus respiratórios (VR) que são os agentes etiológicos mais frequentes nas infecções de vias aéreas, n

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Naninck, Thibaut. "Etude de l'infection par Bordetella pertussis dans un modèle de coqueluche chez le primate non-humain : Apports de l'imagerie in vivo." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS526.

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La coqueluche est une pathologie due à la bactérie Bordetella pertussis qui touche les voies respiratoires des patients infectés causant toux, leucocytose, fièvre, et dont les symptômes peuvent aller jusqu’au décès chez les individus les plus à risque (nouveau-nés et enfants immunodéprimés en particulier). Ciblée par différents programmes vaccinaux depuis de nombreuses années, cette pathologie sévit à nouveau dans de nombreux pays développés où le nombre de cas augmente fortement depuis la fin des années 2000. Cette résurgence montre la nécessité de développer de nouvelles stratégies afin de c

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Apak, Aycan. "Assessment Of Immune Protective Capacity Of The Recombinant Iron-superoxide Dismutase (fesod) From Bordetella Pertussis." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613998/index.pdf.

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Whooping cough (pertussis) is a highly contagious acute respiratory disease caused by the strict human pathogen Bordetella pertussis, a gram-negative coccobacillus. The worldwide mass-vaccination was started in 1940s and to date, a number of whole-cell (Pw) and acellular pertussis vaccine (Pa) formulations were developed. Yet the current vaccines are incapable of providing sustained, lifelong immunity and eliminating subclinical infections, which pose a threat especially for unimmunized infants as well as adolescents and adults. Thus, finding new protein candidates with high immune protective

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