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Artykuły w czasopismach na temat "WM 304"
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Oktadinata, Herry, and Adi Ganda Putra. "MICROSTRUCTURE AND HARDNESS PROFILE OF DISSIMILAR LAP JOINT OF TYPE 304 STAINLESS STEEL TO SS400 CARBON STEEL." Metal Indonesia 41, no. 2 (2019): 46. http://dx.doi.org/10.32423/jmi.2019.v41.47-54.
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Dissimilar metal welds between austenitic stainless steel and carbon steel are commonly used in oil and gas industries for certain reasons. The objective of this research is to asses the effect of filler metal and shielding gas on the microstructure and hardness of dissimilar lap joint of type 304 austenitic stainless steel to JIS SS400 low carbon steel. For the purpose of this investigation, the weldments were produced using flux-cored arc welding (FCAW). Three types of filler metals (E316L, E309L and E308L) and two different gas compositions (100%CO2 and 90%Ar+10%CO2) were selected to be used. Each of the weldments were analyzed on the microstructure characteristic and hardness profile of base metal (BM), heat affected zone (HAZ) and weld metal (WM) using optical microscope and microhardness Vickers. The metallographic examination revealed HAZ-SS400 contains martensites. Both HAZ-304 and WM show austenitic microstructure, with columnar and cellular sub-structures present at WM. The hardness profile of HAZ-304 is higher than BM-304, it may be attributed to the presence of the fine grains in HAZ-304 due to high temperature during welding. The hardness profile of WM-E309L exhibited the hardness from HAZ to WM tend to decrease linearly, while WM-E316L and WM-E308L showed the hardness from HAZ to WM also decreased but drastically dropped at fusion line (FL). The welds using E309L offer the best result in the point of view homogeneity of the hardness profile.
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De Oliveira, Matheus José Cunha, João Gabriel Lúcio Conceição, Martha Nascimento Diniz, et al. "Effect of welding parameters on the microstructure and mechanical behavior of dissimilar AISI 304/AISI 430 thin plates welded by gas Tungsten arc welding." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 21, no. 9 (2023): 10640–56. http://dx.doi.org/10.55905/oelv21n9-010.
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In this work, the microstructure and mechanical behavior of dissimilar AISI 430 and AISI 304 thin sheets welded by Gas Tungsten Arc Welding using AISI 304 and AISI 316L as filler metals were studied. The obtained joints were characterized by optical and scanning electronic microscopy, Energy-dispersive X-ray spectroscopy and fluorescence, tensile tests and the Vickers microhardness test. Measurements carried out by energy dispersion X-ray spectrometry in the melting zone indicated a slightly heterogeneous distribution of nickel and iron. It was observed that the beginning of solidification of the zone fusion occurred through epitaxial growth. The WM solidification morphology was basically cellular influenced by temperature gradient, solidification rate and chemical composition. Variations in chemical composition and solidification morphology did not significantly alter the Vickers microhardness values in the melting zone. Results obtained in tensile tests indicated adequate mechanical behavior for the joints using AISI 304 as filler rod; those exhibited a ductile fracture behavior with the presence of dimples. However, the AISI 316L joints failure prematurely resulting in a fragile behavior.
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Xu, Hu, Junsheng Sun, Jun Jin, Jijun Song, and Chi Wang. "Comparison of Structure and Properties of Mo2FeB2-Based Cermets Prepared by Welding Metallurgy and Vacuum Sintering." Materials 14, no. 1 (2020): 46. http://dx.doi.org/10.3390/ma14010046.
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At present, most Mo2FeB2-based cermets are prepared by vacuum sintering. However, vacuum sintering is only suitable for ordinary cylinder and cuboid workpieces, and it is difficult to apply to large curved surface and large size workpieces. Therefore, in order to improve the flexibility of preparing Mo2FeB2 cermet, a flux cored wire with 70% filling rate, 304 stainless steel, 60 wt% Mo powder and 40 wt% FeB powder was prepared. Mo2FeB2 cermet was prepared by an arc cladding welding metallurgy method with flux cored wire. In this paper, the microstructure, phase evolution, hardness, wear resistance and corrosion resistance of Mo2FeB2 cermets prepared by the vacuum sintering (VM-Mo2FeB2) and arc cladding welding metallurgy method (WM-Mo2FeB2) were systematically studied. The results show that VM-Mo2FeB2 is composed of Mo2FeB2 and γ-CrFeNi.WM-Mo2FeB2 is composed of Mo2FeB2, NiCrFe, MoCrFe and Cr2B3. The volume fraction of hard phase in WM-Mo2FeB2 is lower than that of VM-Mo2FeB2, and its hardness and corrosion resistance are also slightly lower than that of VM-Mo2FeB2, but there are obvious pores in the microstructure of VM-Mo2FeB2, which affects its properties. The results show that WM-Mo2FeB2 has good diffusion and metallurgical bonding with the matrix and has no obvious pores. The microstructure is compact and the wear resistance is better than that of VM-Mo2FeB2.
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Moon, Kyung Man, Yun Hae Kim, Sung Jin Kim, et al. "Electrochemical Evaluation on the Corrosion Properties of Welding Zones of 304 Stainless Steel." Advanced Materials Research 146-147 (October 2010): 1238–42. http://dx.doi.org/10.4028/www.scientific.net/amr.146-147.1238.
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Two types of welding methods were performed on austenitic 304 stainless steel: laser welding and TIG welding. The differences of the corrosion characteristics of the welded zones from the two welding methods were investigated with electrochemical methods, such as measurement of the corrosion potential, polarization curves, cyclic voltammogram, etc. The Vickers hardness of all laser-welded zones (WM:Weld Metal, HAZ:Heat-Affected Zone, BM:Base Metal) was relatively higher while their corrosion current densities exhibited a comparatively lower value than those which were TIG welded. In particular, the corrosion current density of the TIG-welded HAZ had the highest value among all other welding zones, which suggests that chromium depletion due to the formation of chromium carbide occurs in the HAZ, which is in the sensitization temperature range, thus it can easily be corroded with an active anode. Intergrenular corrosion was also observed at the TIG-welded HAZ and WM zones. Consequently, we can see that corrosion resistance of all austenitic 304 stainless steel welding zones can be improved via the use of laser welding.
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Barabadi, Negin Sattari, Abhishek Dave, Hamid Niknazar, et al. "0224 Chronic change in sleep oscillation expression in older adults with insomnia with zolpidem or lemborexant and its effect on memory." SLEEP 46, Supplement_1 (2023): A98—A99. http://dx.doi.org/10.1093/sleep/zsad077.0224.
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Abstract Introduction Aging is accompanied by increased insomnia and memory decline. Enhancing GABAergic and antagonizing orexinergic function are both ways to treat insomnia, but how these mechanisms impact sleep oscillations, and consequently memory, among older adults with insomnia is unknown. Thus, chronic effects of zolpidem and lemborexant on quantitative sleep electroencephalography (EEG) and quality of memory among older adults with insomnia were evaluated. Methods 116 older adults (71.01±4.81y, 78.67% female) with insomnia (Insomnia Severity Index 18.73±3.13) completed a phase 3 study (E2006-G000-304; NCT02783729) with placebo (n=29), zolpidem-extended-release (6.25mg,n=26;ZOL), and lemborexant (5mg,n=29[LEM5]; 10mg,n=32[LEM10]) using polysomnography before (at baseline) and 29-30 days after chronic treatment. Spectral analysis was performed on artifact-free EEG data during NREM sleep. Changes in relative power within canonical frequency bands (i.e., slow-oscillation[0.5-1Hz], delta[1-4.5Hz], theta[4.5-7.5Hz], alpha[7.5-11Hz], slow-sigma[11-13Hz], fast-sigma[13-16Hz], beta[16-28Hz] and gamma[28-35Hz]) from baseline were compared between groups at averaged frontal electrodes at each visit. Working (WM) and episodic memory (EM) were measured at waketime using ANOVA models and Pearson correlations. Results A significant main effect of intervention on frequency bands delta (p=0.02), slow-sigma (p<.001), and fast-sigma (p<.001) was found, with greater chronic suppression in power for ZOL compared to PBO for delta (p=0.002). Compared to PBO, ZOL showed greater increase in power for slow-sigma (p<.001), fast-sigma (p<.001) and beta (p=.03), and was also associated with greater increases in power compared to LEM5 for slow-sigma (p<.001) and fast-sigma (p=.006), and compared to LEM10 for alpha (p=.04), slow-sigma (p< 0.00), and fast-sigma (p<.001). LEM5 showed greater beta (p=.05) than PBO. WM was significantly higher (better) for LEM5 compared to PBO (p=0.04), while EM was higher for PBO compared to ZOL (p=0.01). Increase in beta with ZOL was related to decreased change-from-baseline-WM (r=-0.43, p=.03); increases in theta and alpha with LEM5 were related to decreased change-from-baseline-EM [r=-0.38, p=0.04; r=-0.39, p=0.03]; and increase in delta with LEM10 was related to increased change-from-baseline-EM (r=0.43, p=0.02). Conclusion In older adults with insomnia disorder, chronic treatment with lemborexant and zolpidem had distinct effects on sleep oscillation expression and between power and memory. Functional consequences of these differential effects on sleep-oscillation expression and memory in insomnia patients should be further considered. Support (if any) Eisai
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Davids, Matthew S., Andrew W. Roberts, Mary Ann Anderson, et al. "The BCL-2-Specific BH3-Mimetic ABT-199 (GDC-0199) Is Active and Well-Tolerated in Patients with Relapsed Non-Hodgkin Lymphoma: Interim Results of a Phase I Study." Blood 120, no. 21 (2012): 304. http://dx.doi.org/10.1182/blood.v120.21.304.304.
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Abstract Abstract 304 Background: BCL-2 is highly expressed in indolent non-Hodgkin lymphomas (NHL), mantle cell lymphoma (MCL) and other selected aggressive lymphomas, and is a promising target for therapeutic intervention. The first-generation BCL-2 inhibitor navitoclax showed some activity in indolent lymphoma, but its co-inhibition of BCL-xL resulted in dose-limiting thrombocytopenia, precluding the full exploration of the potential of BCL-2 inhibition with this drug in NHL. ABT-199 is an orally bioavailable, second-generation BH3-mimetic that inhibits BCL-2 (Ki<0.10 nM), but has 500-fold less activity for BCL-xL (Ki=48 nM). ABT-199 demonstrated antitumor activity against a variety of human cell lines and xenograft models that include B cell NHL, follicular lymphomas (FL), diffuse large B-cell Lymphoma (DLBCL) and MCL. Methods: This is a phase-I dose-escalation trial using a modified Fibonacci design in patients with relapsed/refractory NHL. The primary objectives of this study are to determine the safety, pharmacokinetics (PK) and maximum tolerated dose (MTD) of ABT-199; to recommend a phase-2 dose; and to assess efficacy and biomarkers in patients with relapsed/refractory NHL. Adult patients requiring therapy, with ECOG performance status £1, and adequate marrow function received ABT-199 on Week 1 Day −7 (W1D-7), followed by continuous once-daily dosing from W1D1, until progressive disease (PD) or unacceptable toxicity. Due to concerns of potential tumor lysis, a strategy of commencing with a 2 to 3 week lead-in period with step-wise increases to the target cohort dose is being evaluated. In the first four cohorts, the starting dose increased from 50 to 200 mg (50, 100, 200, and 200 mg, respectively), with target cohort doses of 200 mg [n=3], 300 mg [n=3], 400 mg [n=4], and 600 mg [n=7]. Evaluations include: adverse events (AE; NCI-CTCAE-V4) and tumor response (IWG 2007 criteria). Results: To date, 17 patients (median age, 71 [35–85]) have been treated with ABT-199. Median prior therapies were 3 (range, 1–7) and 6 patients had bulky adenopathy (>5cm). Most common AEs (experienced by >2 patients) were nausea (41%), diarrhea (24%), dyspepsia (24%), fatigue (24%), extremity pain (24%); and anemia, constipation, upper respiratory tract infection and cough (18% each). Grade 3 or 4 AEs occurring in >1 patient were anemia (18%) and neutropenia (12%). Treatment-related thrombocytopenia has not been reported and no dose-limiting toxicities (DLTs) have been identified to date. After a single dose administration with a high-fat meal, ABT-199 reached Cmax at approximately 7 hrs with a terminal half-life of about 15 hrs. Food increased ABT-199 exposure by approximately 3-fold. With a median follow-up of 2.8 months (range, 1.2 to 10.8), 14 patients remain on study and 3 have discontinued due to PD. In patients who have completed at least a W6 assessment, reductions of >50% in target lesions have been observed in 8/15 patients (53%); 6/6 patients with MCL, 1/2 patients with WM and 1/2 patients with DLBCL. Additionally, 5 FL patients have been evaluated (3 with rituxan-refractory disease) with a median time on study of 6.4 months (range, 3.5 to 10.8). 4/5 FL patients had nodal disease reductions ranging from 18% to 40%. Conclusions: ABT-199 shows single agent anti-tumor activity in patients with NHL; particularly in MCL. Activity is also observed in DLBCL and WM. To date, no DLTs have been identified and tumor lysis syndrome related to ABT-199 has not been reported. Dose escalation is continuing to identify the optimal dosing regimen and MTD of ABT-199 in NHL. Updated results will be presented. Disclosures: Roberts: Abbott: Research Funding; Genentech: Research Funding. Anderson:Genentech: Research Funding; Abbott: Research Funding; Walter and Eliza Hall Institute of Medical Research: Employment, receives commercial income related to ABT-199, receives commercial income related to ABT-199 Other. Kahl:Genentech: Consultancy, Research Funding; Abbott: Research Funding. Darden:Abbott: Employment, owner of Abbott stock Other. Nolan:Abbott: Employment, own Abbott stock Other. Gressick:Abbott: Employment, stock owner Other. Yang:Abbott: Employment, own Abbott stock Other. Chyla:Abbott: Employment, Stock owner Other. Busman:Abbott: Employment, Stock owner Other. Graham:Abbott: Employment, Stock owner Other. Cerri:Abbott: Employment, Stock owner Other. Enschede:Abbott: Employment, own Abbott stocks Other. Humerickhouse:Abbott: Employment, own Abbott stocks Other. Seymour:Roche: Advisory board member, Advisory board member Other, Consultancy; Genentech: Advisory board member, Advisory board member Other, Consultancy.
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Macedo, Alice Dos Santos, and Gilberto Fisch. "Variabilidade Espacial da Radiação Solar na Região de Manaus - AM durante o Experimento GOAmazon 2014/15 (Spatial variability of solar radiation in Manaus-AM region during GOAmazon Experiment 2014/15)." Revista Brasileira de Geografia Física 10, no. 6 (2017): 1802. http://dx.doi.org/10.26848/rbgf.v10.6.p1802-1811.
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Este trabalho realizou um estudo da variabilidade espacial em 2014 da irradiância solar na região de Manaus-AM, através de dados observacionais, inserido no Projeto GOAmazon 2014/15. Também, como forma complementar, foi realizada a análise da cobertura de nuvens, chuva e aerossóis e suas interrelações com a irradiância solar. Como resultado, observa-se que os menores valores médios da irradiância solar ocorreram na área urbana,o que é justificado, em parte pela urbanização que altera os fluxos envolvidos, diminuindo a irradiância solar à superfície. Os valores típicos são entre 400 e 600 Wm-2na estação chuvosa (fevereiro/março) com um desvio padrão de 200 e 380 Wm-2e entre 650 e 800 Wm-2na estação seca (agosto-setembro) com desvio padrão de 190 e 300 Wm-2. A B S T R A C T The solar radiation is an important climatic element in the Amazon region, as it has a strong impact for ecological (by the preservation of the biodiversity) and technological (as a renewable energy) areas. Consequently, this study contributes for these themes, conducting an observational study of the spatial variability of the solar irradiance for Manaus-AM area, with data collected during the project GOAmazon 2014/15. The cloud cover and rainfall and their relationships with solar radiation were also analysed. The maximum values observed for the wet season (february and march) are in the range 450 and 600 Wm-2 with high standart deviation (300 - 350 Wm-2 ), while they are in the range from 650 and 800 Wm-2 during the dry period (august - september) with lower standart deviation (200 - 300 Wm-2). These values are directly associated with cloud cover and rainfall. In general, the urban area (Manaus city) showed the low values of solar radiation at the surface compared with its neighborhood, inducing a horizontal gradient of clouds/rainfall and solar energy between the city and the semi rural areas. Keywords: piranometer, global solar radiation, cloud cover, total sky imager
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Cordero - Au Yeung, Rie Sheena, and Marilyn Tiongson. "The Impact of Talent Management Practices on Organizational and Human Resources Outcomes: A Study on Philippines Department Of Foreign Affairs Talent Management Practices." International Journal of Scientific Research and Management 10, no. 11 (2022): 1288–301. http://dx.doi.org/10.18535/ijsrm/v10i11.sh02.
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The study examined the Philippine Department of Foreign Affairs (DFA) talent management practices and whether its practices influence its organizational and human resources outcomes. The three independent variables are talent attraction, talent development, and talent retention, while the two dependent variables are organizational and human resources outcomes. Three hundred respondents answered a 43-item questionnaire. The Pearson's Correlation analysis results show significant positive relationships between organizational outcomes and (a) talent attraction, r=.734, N=300, p < 0.001; (b) talent development, r=.699, N=300, p < 0.001, and (c) talent retention, r=.748, N=300, p < 0.001. Likewise, the analysis showed that there are significant positive relationships between human resource outcomes and (a) talent attraction, r=.753, N=300, p < 0.001; (b) talent development, r=.765, N=300, p < 0.001, and (c) talent retention, r=.808, N=300, p < 0.001. The study revealed that talent attraction, development, and retention positively influence organizational and human resources outcomes. Talent Development is the primary strength of the Department with the highest weighted mean (WM:3.71; SD:0.78), followed by Talent Attraction (WM:3.56; SD:0.81) and talent retention (WM:3.27; SD:0.90).
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Lund, Sigrun Helga, Malin Hultcrantz, Lynn Goldin, et al. "Patterns of Infectious Morbidity in Patients with Waldenström’s Macroglobulinaemia/Lymphoplasmacytic Lymphoma: A Population-Based Study." Blood 124, no. 21 (2014): 3350. http://dx.doi.org/10.1182/blood.v124.21.3350.3350.
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Abstract Background Infections are a major cause of morbidity and mortality in patients with hematologic malignancies. However, largely due to the rarity of Waldenström’s macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL), the literature on infectious morbidity is limited. Using population-based data from Sweden, we estimated the risk of bacterial and viral infections among 2,608 LPL/WM patients compared to 10,433 matched controls. Patients and Methods We identified all WM/LPL patients diagnosed 1980-2005 in the nationwide Swedish Cancer and Patient Registries, as well as a national network database including all major hematology/oncology centers; duplicate records were removed. Follow-up time was up to 2006. For each WM/LPL patient, four population-based controls (matched by age, sex, and county of residence) were identified randomly from the Swedish population database. Information on type of infection and date of infection was obtained from the Patient Registry which captures information on all individual patient-based discharge diagnosis from inpatient (since 1964) and outpatient care (since 2000). Through linkage to the nationwide Cause of Death Registry, we identified dates of death for WM/LPL patients and controls. Cox proportional hazard models were used to estimate the overall risk of infections. Models were adjusted for sex, age, and calendar period. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for individual infections. Results Overall, WM/LPL patients had a 3.4-fold (95% CI=3.1-3.6) elevated risk of developing any infection than controls (Figure). Compared to controls, the risk of developing bacterial and viral infections was 3.2-fold (95%; CI=2.9-3.5) and 6.0-fold (95% CI=4.9-7.3) higher, respectively. More specifically, WM/LPL patients had an increased risk (p<0.05) of the following types of bacterial infections: septicaemia (HR=9.3; 95% CI 3.7-23.5), endocarditis (HR=5.0; 95% CI 2.5-10.0), pneumonia (HR=3.8; 95% CI 3.4-4.2), meningitis (HR=3.4; 95% CI 1.1-10.3), cellulitis (HR=2.6; 95% CI 2.0-3.4), osteomyelitis (HR=1.9; 95% CI 1.01-3.6), and pyelonephritis (HR=1.6; 95% CI 1.2-2.4). Regarding viral infections, WM/LPL patients had an increased risk of herpes zoster (HR=9.2; 95% CI 6.7-12.6) and influenza (HR=2.3; 95% CI 1.5-3.5). The risk of infections was highest during the first year after diagnosis. Interestingly, WM/LPL patients diagnosed in the more recent calendar periods had significantly higher risk of infections (Figure). Compared to WM/LPL patients diagnosed in 1980-1989, patients diagnosed in 1990-1999 and 2000-2004 had a 1.5-fold (95% CI=1.3-1.6) and 1.8-fold (95% CI=1.6-2.1) increased risk of any infection, respectively. The same patterns were observed when bacterial infections were analyzed separately. In analysis focusing on viral infections; there was only a significant increased risk during the most recent calendar period (p=0.027). Females had a significantly lower risk of infections compared to males (p<0.001). Increasing age was significantly associated with a higher risk of infections (p<0.001). Discussion In this large population-based study including over 2,600 WM/LPL patients and 10,000 matched controls, we found that bacterial and viral infections represent a major threat to WM/LPL patients. This was particularly true during the first years following diagnosis. Importantly, the risk of infections increased in more recent years. The effects on infectious complications due to novel drugs in the treatment of WM/LPL need to be better defined and trials on prophylactic measures are needed. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Lin, Yu-Ru, Tien-Wei Hsu, Che-Wei Hsu, Peng-Yu Chen, Ping-Tao Tseng, and Chih-Sung Liang. "Effectiveness of Electroencephalography Neurofeedback for Improving Working Memory and Episodic Memory in the Elderly: A Meta-Analysis." Medicina 60, no. 3 (2024): 369. http://dx.doi.org/10.3390/medicina60030369.
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Background and Objective: Existing evidence indicates the potential benefits of electroencephalography neurofeedback (NFB) training for cognitive function. This study aims to comprehensively review all available evidence investigating the effectiveness of NFB on working memory (WM) and episodic memory (EM) in the elderly population. Material and Methods: A systematic search was conducted across five databases to identify clinical trials examining the impact of NFB on memory function in healthy elderly individuals or those with mild cognitive impairment (MCI). The co-primary outcomes focused on changes in WM and EM. Data synthesis was performed using a random-effects meta-analysis. Results: Fourteen clinical trials (n = 284) were included in the analysis. The findings revealed that NFB was associated with improved WM (k = 11, reported as Hedges’ g = 0.665, 95% confidence [CI] = 0.473 to 0.858, p < 0.001) and EM (k = 12, 0.595, 0.333 to 0.856, p < 0.001) in the elderly, with moderate effect sizes. Subgroup analyses demonstrated that NFB had a positive impact on both WM and EM, not only in the healthy population (WM: k = 7, 0.495, 0.213 to 0.778, p = 0.001; EM: k = 6, 0.729, 0.483 to 0.976, p < 0.001) but also in those with MCI (WM: k = 6, 0.812, 0.549 to 1.074, p < 0.001; EM: k = 6, 0.503, 0.088 to 0.919, p = 0.018). Additionally, sufficient training time (totaling more than 300 min) was associated with a significant improvement in WM (k = 6, 0.743, 0.510 to 0.976, p < 0.001) and EM (k = 7, 0.516, 0.156 to 0.876, p = 0.005); however, such benefits were not observed in groups with inadequate training time. Conclusions: The results suggest that NFB is associated with enhancement of both WM and EM in both healthy and MCI elderly individuals, particularly when adequate training time (exceeding 300 min) is provided. These findings underscore the potential of NFB in dementia prevention or rehabilitation.
Rozprawy doktorskie na temat "WM 304"
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Engel, Camille. "Description phénotypique de formes rares de trouble du développement intellectuel et caractérisation des mécanismes moléculaires impliqués." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCE006.
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L’avènement des nouvelles techniques de séquençage a permis d’augmenter de façon considérable le taux diagnostique des troubles du développement intellectuel (TDI) et plus de 2000 gènes impliqués sont aujourd’hui connus. Malgré ces progrès considérables, l’interprétation des variants identifiés par les techniques de séquençage reste parfois difficile et l’histoire naturelle des TDI nouvellement décrits est souvent méconnue. Notre travail a consisté à étudier quatre formes de TDI rares de modes de transmissionvariés sur les plans clinique et génétique afin de mieux comprendre ces affections et les mécanismes qui les sous-tendent. Nous avons d’une part précisé les tableaux cliniques associés aux variations de BRAT1, CNOT3 et MTOR et avons recherché l’existence d’éventuelles corrélations phénotype-génotype pour les variations de ces gènes. D’autre part, nous avons participé à la mise en place d’un test fonctionnel permettant de reclasser les variants de signification incertaine de PQBP1<br>The advent of new sequencing techniques has dramatically increased the diagnostic rate of intellectual disability (ID), and more than 2,000 genes are currently known to be involved. Despite these considerable progresses, interpreting the variants identified by sequencing methods remains challenging, and the natural history of newly described ID is often poorly understood. To better understand these disorders and their underlying mechanisms, we have studied four rare forms of ID with various inheritance patterns from both clinical and genetic perspectives. On one hand, we defined the clinical pictures associated with variations in BRAT1, CNOT3 and MTOR, and we investigated the existence of any phenotype-genotype correlations. On the other hand, we contributed to the design of a functional test to reclassify PQBP1 variants of uncertain significance
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Clegg, Jennifer. "Interactions and relationships in adults with intellectual disability." Thesis, University of Nottingham, 1990. http://eprints.nottingham.ac.uk/11065/.
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This research concerned the social experience of two groups of adults with intellectual disability (mental handicap), those with verbal skills who could describe their experience and those with profound disabilities whose needs were interpreted by carers. Conceptual issues have been discussed to provide a framework for understanding their relationships and also for understanding intellectual disability itself. Social constructionism, has influenced the investigations. Previous research shows that disabled people experience relatively little social contact regardless of their level of ability. Interactions and relationships were investigated so that practitioners aiming to improve intellectually disabled adults' social experience may have relevant information. It has been assumed that more interaction is better as it allows people to reflect upon themselves with regard to others, to construct themselves through their interactions. These investigations fall into two main sections, the first a discussion of attitudes toward self and others held by people who had, or did not have, a peer-group friend. Results suggested that further examination of the role of the self-concept in friendship formation would be fruitful and that people without a peer-group friend were similar to lonely non-disabled adults. The second section examines profound disability and contains a linked series of studies of adults' interactions with key workers. Results suggested that two interaction strategies used by staff were associated with increased positive responding from clients; that the developmental age of clients did not distinguish between them in their social responses to staff; that there was little evidence of turn-taking or the importance of staff making responses which follow the client's lead. Results were discussed in terms of their contribution to an alternative model for understanding profound disability. The project as a whole was discussed in terms of the interaction between method and conceptualisation and concludes with a number of recommendations for practitioners.
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Cant, Richard. "Offenders with learning disabilities : the involvement & attitudes of professionals." Thesis, University of Nottingham, 2002. http://eprints.nottingham.ac.uk/12378/.
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It has been reported that there is an over-representation of people with learning disabilities in prison populations. Various explanations have been offered for this including theories that people with disabilities are susceptible to criminal behaviour, and that they receive different treatment within the justice system. There is no evidence of over-representation of people with learning disabilities in the UK penal system although evidence does suggest that there are a significant number of prisoners with borderline learning disabilities who are psychologically vulnerable. This research set out to examine current levels of contact that psychiatrists have with various criminal justice agencies, as well as exploring the attitudes and beliefs of other criminal justice workers in order to assess current arrangements of treatment and care for offenders who have a learning disability. 791 consultant psychiatrists registered in four sections of the Royal College of Psychiatry were surveyed to detect current levels of contact with five criminal justice agencies, and also to assess their levels of involvement with the diversion of mentally disordered offenders into health care provision. Responses indicated that forensic and general psychiatrists had the highest levels of contact with criminal justice agencies, although there was also limited contact with child and learning disability psychiatrists. Forensic psychiatrists were also shown to be the group who were most likely to be involved with diversion schemes, and there was some evidence to suggest that respondents were unhappy with current arrangements for diversion because of bed and staff shortages. An attitude survey concerning offenders with learning disabilities was distributed to 100 criminal justice professionals (judges, magistrates, police and appropriate adults). 28 of these respondents also participated in semi-structured interviews which provided qualitative data to supplement the findings of the attitude survey. These studies provided evidence that criminal justice professionals were not eager to assign special rights to people because of their learning disability status, but instead were confident that the present legal system could accommodate the needs of offenders with learning disabilities in the present system. However, significant concern was raised by all respondents that specific training in needed to address learning disability issues before this can be fully achieved. There was little evidence found to support `susceptibility' theories of learning disability offending, although there was some evidence which gave support to the `different treatment' hypothesis.
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Piard, Juliette. "Déficience intellectuelle : identification de nouveaux gènes par une approche multicentrique." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCE005.
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La déficience intellectuelle (DI) touche 1 à 3% de la population générale avec un excès de sujets de sexe masculin. Cette affection est caractérisée par une extrême hétérogénéité clinique et génétique rendant son élucidation complexe. La révolution technologique des outils permettant l’analyse du génome intervenue depuis les années 2000 avec l’analyse chromosomique sur microréseau et singulièrement depuis 2010 avec les applications du séquençage à haut débit a considérablement facilité l’identification de nouveaux gènes. Nous avons tiré avantage de ce phénomène pour identifier trois affections neurologiques à caractère familial Nous avons procédé selon une méthodologie structurée pour conduire, grâce à la mise en place d’un réseau de collaborations, à la découverte ou à la confirmation de l’existence de nouvelles formes de DI. 1.Séquençage de l'exome couplé à la recherche de variations du nombre de copies 2. Mise à jour d’une altération de séquence génique potentiellement causale retrouvée chez le cas index et chez les autres sujets atteints de la famille 3.Extension des résultats à d’autres familles par la constitution d’une cohorte de réplication 4.Élaboration d’une série d’études fonctionnelles venant conforter l’hypothèse de causalité par la création d’un modèle animal et/ou la réalisation d’études biochimiques spécifiquesL’application de cette méthodologie nous a permis de conduire à terme trois projets : L’individualisation d’une forme syndromique de DI récessive autosomique associée à une malformation du rachis cervical et liée aux mutations bi-alléliques de CDK10. La caractérisation d’une encéphalopathie récessive autosomique létale associée à une hypertonie sévère et à une arthrogrypose distale liée aux mutations bi-alléliques d’ATAD1. L’implication de FRMPD4 dans une nouvelle forme de DI non syndromique liée à l’X<br>Intellectual disability (ID) impacts 1 to 3% of the general population with an excess of affected males. This condition is characterized by an extreme clinical and genetic heterogeneity making the deciphering of its causes more complex. The technological revolution that took place in the study of the genome over the last two decades has provided a useful tool for identification of new genetic entities. This is particularly true for chromosomal micro-array analysis since early 2000s and for next generation sequencing since 2011. We took advantage of this by identifying the molecular basis of three singular conditions. We applied a structured methodology and created a network of collaborations to define or confirm these new ID syndromes. 1. Whole exome sequencing alongside with array-CGH 2.Identification of a candidate gene sequence alteration in the index case and other affected patients of the family 3.Constitution and study of a replication cohort 4.Biochemical studies and/or animal models in order to support the assumption of causalityBased on this research strategy, we were able to complete the following projects : Discovery of a syndromic form of autosomal recessive ID associated with cervical spine defects due to bi-allelic CDK10 mutations. Identification of an ATAD1-related profound and lethal autosomal recessive encephalopathy with stiffness and distal arthrogryposis. Characterization of a FRMPD4-related X-linked non-syndromic ID
Książki na temat "WM 304"
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J, Smith Christopher, and Giggs John A, eds. Location and stigma: Contemporary perspectives on mental health and mental health care. Unwin Hyman, 1988.
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Freud, Sigmund. ON MURDER, MOURNING AND MELANCHOLIA; TRANS. BY SHAUN WHITESIDE. PENGUIN BOOKS, 2005.
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Michael, Beveridge, and Leudar Ivan 1949-, eds. Language and communication in people with learning disabilities. Routledge, 1997.
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Nick, Bouras, and Holt Geraldine 1951-, eds. Psychiatric and behavioural disorders in intellectual and developmental disabilities. 2nd ed. Cambridge University Press, 2007.
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Association, American Psychiatric, ed. DSM-5 handbook of differential diagnosis. American Psychiatric Publishing, a division of American Psychiatric Association, 2014.
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Williams, Richard, 1950 Sept. 18- and Kerfoot Michael, eds. Child and adolescent mental health services: Strategy, planning, delivery and evaluation. Oxford University Press, 2005.
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The challenge: Agent, Wm. Payne, bicycle & importer, P.O. Box 304 London, Ontario. s.n., 1986.
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Niv Bible Wm Cloth Bible NIV WM Cloth 300 XRL. Cambridge University Press, 1998.
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The Economics of Mental Health Care: Industry, Government and Community Issues. Ashgate Pub Ltd, 2002.
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Thomas, Manuel, Raghu V. Prakash, Ganesh Sundararaman, and Vasudevan Muthukumaran. "Fatigue Crack Growth Rate Studies on Stainless Steel Welds." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-86915.
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The low carbon, nitrogen enhanced SS 304 L(N) stainless steels are one of the most potential candidates for the structural members in chemical industries and powerplants operating at hostile environments of temperature and corrosion. In service, the structural members fabricated using welding process, when subjected to a combination of mechanical load and elevated temperature can fail by fatigue. The Welding of Austenitic stainless steels using Tungsten Inert gas (TIG) is often limited by the depth of weld penetration, which can be achieved during a single pass. This necessitates for the use of multiple passes resulting in weld distortion and generation of residual stress. The Use of an electronegative flux (Activating flux) during the TIG welding (A-TIG) is known to enhance the weld penetration, thereby reducing the number of passes. The present study evaluates the fatigue crack growth in stainless steel weldment (304L(N) welds) joined using conventional Multipass TIG welding and Activated flux TIG welding at 673K. Compact Tension (C(T)) specimens having a width of 50.8 mm and a thickness of 4 mm were extracted from the location of heat-affected zone (HAZ) and weld metal (WM) for A-TIG and MP-TIG configurations. From the micro-structural evaluation of A-TIG welds, it is noted that high heat input in a single pass has favored the formation of coarse equiaxed grains along the weld center. The use of multiple passes at reduced heat input has resulted in the formation of finer grains, with the orientation of grains changing along each weld pass interface. This finer randomly oriented grains has resulted in increasing crack path resistance through the MP-TIG welds compared to A-TIG welds. Thus from a view point of fatigue crack growth, due to the presence of fine grains, conventional Multi-pass weld is superior compared to A-TIG, but in cases where there is a creep or creep-fatigue combination, the A-TIG weld may prove to be useful.
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Reifenberg, J., R. England Voss, P. Rao, et al. "Thermal Conductivity Measurements of Thin Aluminum Layers Using Steady State Joule Heating and Electrical Resistance Thermometry in Suspended Bridges." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-42055.
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Thin metallic film layers are extensively used as the constituents of the micro-devices. The reliability of these devices, therefore, strongly depends on the thermal behavior of such film layers. Aluminum thin film layers are of particular interest in this respect. The lateral thermal conductivity of the aluminum film layers is measured, using the steady state electrical Joule heating and electrical resistance thermometry technique. Aluminum suspended microbridges of identical thicknesses (500 nm) and variable widths (16 to 18 μm) and/or lengths (200 to 500 μm) are fabricated, using conventional microfabrication processes. The lateral thermal conductivity of the 500 nm thick Aluminum film layer was found to be k = 174 ± 13 Wm−1 K−1, at room temperature (300 K).
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Ibrahim, M. M., H. G. Mohamed, and Y. E. Tawfik. "Effect of PWHT Cycles on Impact Toughness of Austenitic Stainless Steel Weldments." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75033.
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Austenitic stainless steels are widely used welding materials in nuclear reactors and power plants because of their high strength, good ductility, excellent corrosion resistance and a reasonable weldability. These properties make austenitic stainless steels attractive candidate materials for use in the fabrication of piping systems, automotive exhaust gas systems and in a variety of equipment associated with the chemical and nuclear power industries. PWHT is a stress relieving process whereby residual stresses are reduced by typically heating to 550–650 °C for a set time depending upon plate thickness. It concerns have emerged about possible effects on the mechanical properties of the base (parent) and weld plates (PM and WM). The 6 mm AISI 304L, 316L, and 347 austenitic stainless steels were used for this work. These welds were produced by SMAW and GTAW techniques using a single vee preparation and multiple weld beads, and welded by various types of consumables. The fracture surfaces of the Charpy V-notch PM and WM (before and after PWHT) samples were examined by SEM. Scanning electron fractographs was critical in this study, in that valuable information regarding the mechanism and nature of failure could be determined. This paper reports work on the impact toughness of the three types of austenitic stainless steels. The parent and weld regions were examined for all types of steels used, and then exposed to temperature in the PWHT range. The effect of exposure to multiple PWHT cycles on these properties is discussed. A decrease in impact energy and fracture toughness with an increase in the number of heat treatments was evident in the parent metal. Similary, the weld metal showed a decrease in impact energy after two PWHT cycles.
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Srinivasan, Uma, Peter Breh, Mehdi Asheghi, Maxat Touzelbaev, and Kenneth E. Goodson. "Thermal Conductivity of Porous Silicon Layers for MEMS." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0323.
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Abstract Porous silicon is a promising material for MEMS because of its unique electrical, thermal, optical, and absorptive properties. This work measures the thermal conductivity of a silicon layer with 40 percent porosity at temperatures between 20 and 300 K using Joule heating and electrical-resistance thermometry. The room-temperature thermal conductivity is 0.43 Wm−1K−1, which is almost three orders of magnitude less than the value for single-crystal silicon. The data are interpreted using a new model based on electron microscopy, which shows a sponge-like morphology with embedded crystalline regions. The model separately treats the contributions of the sponge-like material, in which the solid regions are assumed to be amorphous silicon, and the larger crystallites, in which the conductivity is reduced by boundary scattering. The present work is particularly useful for MEMS based on silicon with porosity below 50 percent, for which no thermal conductivity data were previously available.
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Ibrahim, M. M., H. G. Mohamed, Y. E. Tawfik, and Ibrahim Taha. "Evaluation of Cross-Weld Properties of Austenitic Stainless Steels Before and After PWHT." In 16th International Conference on Nuclear Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/icone16-48043.
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Different types of austenitic stainless steels, which are commonly used for piping systems, tanks, and vessels, required postweld heat treatment (PWHT), at temperatures between 540 and 590 °C, regardless of the plate thickness. This paper reports on the weld procedures and cross-weld performance evalution of weldments in 6 mm AISI 304L, 316L, and 347 steel plates before and after PWHT. This welds were produced by SMAW and GTAW techniques using a single vee preparation and multiple weld beads, and welded by various types of consumables. After PWHT, tensile tests indicated a reduction in the ultimate tensile strength of all samples and a decrease in the yield strength for some cases only. The hardness results were consistent with the tensile test results because they both revealed significant softening in the HAZ and WM as a result of PWHT. In spite of the fact that PWHT exerts a beneficial effect on reducing residual stresses, it is concluded that the ductility of the weld region was satisfactory without PWHT, and PWHT decreased the cross-weld tensile strength.
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Momeni, Amir Farid, Robert J. Peterman, B. Terry Beck, Chih-Hang John Wu, and Naga Narendra B. Bodapati. "Effect of Prestressing Wire Indentation Type on the Development Length and Flexural Capacity of Pretensioned Concrete Crossties." In 2015 Joint Rail Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/jrc2015-5739.
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Load tests were conducted on pretensioned concrete prisms cast with 13 different 5.32-mm-diameter prestressing wire types that are used in the manufacture of pretensioned concrete railroad ties worldwide. The tests were specifically designed to evaluate the development length and bonding performance of these different reinforcements. The prestressing wires were denoted “WA” through “WM” and indentation types included smooth, spiral, chevron, diamond, and 2-dot and 4-dot. Four wires were embedded into each concrete prism, which had a 3.5″ (88.9 mm) × 3.5″ (88.9 mm) square cross section. The wires were initially tensioned to 7000 pounds (31.14 KN) and gradually de-tensioned when the concrete compressive strength reached 4500 psi (31.03 Mpa). A consistent concrete mixture with type III cement, water-cement ratio of 0.32 and a 6-in. slump was used for all prisms. Prisms were tested in 3-point-bending at different spans to obtain estimations of the development length of each type of reinforcement. Two identical 69-in.-long (175.26 cm) prisms were load tested, at both ends, for each reinforcement type evaluated. First prisms were tested at 20-in. (50.8 cm) from one end and 13-in. (33.02 cm) from the other end, whereas the second prisms were loaded at 16.5-in. (41.9 cm) from one end and 9.5-in. (24.13 cm) from the other end. Thus, a total of 52 load tests (13 wire types × 4 tests each) were conducted in this study. During each test, a concentrate load with the rate of 300 lb/min (1334 N/min) was applied at mid-span until failure occurred, and values of load, mid-span deflection, and wire end-slip were continuously monitored and recorded. Plots of load-vs-deflection were then compared for prisms with each wire type and span, and the maximum sustained moment was also calculated for each test. The load tests revealed that there is a very large difference in the development length of the different wire types currently used in the manufacture of pretensioned concrete railroad ties. The results imply that there would also likely be large differences in the reserve capacity (beyond first cracking) for pretensioned concrete crossties fabricated with these different reinforcements.
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Luo, Wenwei, Mengjia Hu, Xiaowei Luo, Li Shi, and Xinxin Wu. "Effect of Thermal Cycling on the Microstructure of Nuclear Grade Dissimilar Metal Weld." In 2024 31st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2024. http://dx.doi.org/10.1115/icone31-135730.
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Abstract As the crucial structure in the pressure boundary of the steam generator in the high-temperature gas-cooled reactor (HTGR), it is essential to investigate the microstructure of T22/800H dissimilar metal weld (DMW) under thermal cycling. This is especially critical in the context of rapid temperature fluctuations under extreme conditions, which are likely to inflict irreparable damage on the material’s microstructure, thus posing a severe threat to the service life of the DMW. T22 and 800H base metal (BM) were welded by tungsten inert gas (TIG) welding, filling with UNS N06082 inserts. To investigate the impact of thermal cycling under extreme conditions on the microstructure of DWM, and to accelerate the evolution of microscopic phenomena, simulated thermal cycling tests were carried out at 500°C with a holding time of 1 hour per cycle and 300 cycles at two ramp-up/down rates of 3°C/min and 8°C/min between room temperature and 500°C, respectively, much more serious than the temperature evolution in start-ups and shutdowns during the operation of HTGR. Characterization of the microstructure of three typical failure-prone areas of T22/800H DMWs, namely the T22 base material (BM), the T22 heat-affected zone (HAZ) and the T22/WM fusion zone by optical microscopy (OM), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), compared with that of the as-welded. It is obtained that limited cavities formed at the interface of T22 BM and the weld fusion zone (FZ), due to the prominent difference of thermal expansion, which contributes to the creep and fatigue, especially in the thermal cycling. Some cavities were also found in the fine-grained heat-affected zone (FGHAZ) of T22, ranging from 100 to 700nm in size. It is predicted that the cavities in FGHAZ were resulted from stress relief without preheat and post-weld heat treatment during the manufacturing of T22/800H DMWs. In addition, a mount of cavities, less than 100nm in size, were observed in the T22 BM during the thermal cycling test at 8°C/min; meanwhile, there were also some cavities, ranging from 100 to 300nm, found in the coarse-grained heat-affected zone (CGHAZ). It is supposed that the differences of thermal-physical properties, such as thermal expansion and hardness, make sense for the small cavities under thermal cycling. Sharp notches resulted from oxidization and thermal stress were found at the interfaces between T22 BM and weld metal, except for specimens without simulated thermal cycling.