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Dr.S.S.Subramanian. "Impact of Core Exercises and Alignment Correction Exercises of Bilateral Osteoarthritis Knee on an Octogenarian Subject – Evidenced Study." International Journal of Case Studies 6, no. 7 (2017): 09–14. https://doi.org/10.5281/zenodo.3537549.

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Introduction: An increasing elderly population and longevity is associated with health issues, mainly musculoskeletal ailments, among which osteoarthritis knee was mostly recorded. These degenerative joints can lead to pain, disability and dependency. Aims & Objectives of this Original Research: was to evaluate specific core exercises and alignment correction exercises on obesity and physical functioning on a subject with bilateral osteoarthritis knees study conducted in Chennai, south India. Materials & Methodology: This case study subject aged 87 years with osteoarthritis knee grade
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Raygan, Laleh, Simin Jahani, Nasrin Elahi, Elham Maraghi, Mohammad Fakoor, and Safa Najafi. "The Impact of Self-acupressure on the Pain, Joint Stiffness, and Physical Functioning of Patients With Knee Osteoarthritis." Journal of Client-centered Nursing Care 9, no. 4 (2023): 297–308. http://dx.doi.org/10.32598/jccnc.9.4.543.1.

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Background: People with knee osteoarthritis have a low quality of life due to joint pain and stiffness, severely limiting their daily activities. This study aims to investigate the impact of self-acupressure on the pain, joint stiffness, and physical functioning of patients with knee osteoarthritis. Methods: This randomized clinical trial was conducted on 78 patients aged 50 to 70 with knee osteoarthritis, referred to Imam Khomeini Hospital and private orthopedic clinics in Ahvaz City, Iran, in 2018. The patients were recruited based on the inclusion criteria and then randomly assigned to thre
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Dr., S.S. Subramanian* &. Gladis Sherin. "CHANGES IN BIOMECHANICAL COMPONENTS WITH EXERCISES ON A GERIATRIC OBESE SUBJECT WITH OSTEOARTHRITIS KNEE– AN EVIDENCE BASED STUDY." Indian Journal of Medical Research and Pharmaceutical Sciences 4, no. 7 (2017): 1–7. https://doi.org/10.5281/zenodo.831450.

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Obesity, a globally increasing factor and its impact on healthcare needs to be focused. Geriatric subjects with obesity and osteoarthritis knee changes influences level of dependency, and decrease quality of life. Aims and objectives of this study was to analyse the role of weight reduction exercises, dietary regulations on obesity and physical function, to evaluate the efficacy of exercises based on biomechanical causes and changes that follows. Materials & Methodology: With ethical committee approval and subjects concern, weight reduction exercises with dietary advice along with exercise
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Mortada, M. A., and Y. A. Amer. "AB0987 Knee Reserve: ultrasonographic features of knees in patients with asymptomatic knee osteoarthritis." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1619.2–1619. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3466.

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BackgroundSymptoms of knee osteoarthritis (KOA) vary according to many factors mainly degree of KOA and degree of inflammatory features.The primary goal of treatment the patients with KOA is to maximize long-term health-related quality of life through control of symptoms. Understanding ultrasonographic characteristics of KOA in asymptomatic patients may help in management of knee osteoarthritis.Zagazig scale is a new validated and feasible tool for KOA assessment.ObjectivesTo understand the ultrasonographic features of thepatients with asymptomatic knee osteoarthritisMethodsAmong 245 patients
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Mortada, Mohamed, Ghada A. Dawa, and Youmna A. Amer. "Construct validity of a clinically correlated knee osteoarthritis ultrasonographic scale: a cross-sectional observational study." BMJ Open 11, no. 12 (2021): e048444. http://dx.doi.org/10.1136/bmjopen-2020-048444.

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ObjectivesTo assess the validity of a novel ultrasonographic scale for knee osteoarthritis (KOA) and its relation with the degree of pain and clinical features.DesignA cross-sectional observational study including 245 patients with knee pain who fulfilled the American College of Rheumatology criteria for KOA. All patients were subjected to clinical assessment Western Ontario and McMaster Universities Index of Osteoarthritis (WOMAC) scale, global visual analogue scale (VAS) and functional assessment through the use of Health Assessment Questionnaire-II (HAQ-II). Ultrasonographic assessment was
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Leung, Y. Y., J. Thumboo, S. J. Yeo, V. Wylde, and A. Tennant. "POS1113 CONSTRUCT VALIDITY, RELIABILITY, RESPONSIVENESS AND INTERVAL SCALE TRANSFORMATION OF THE WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX (WOMAC) IN PATIENTS UNDERGOING KNEE ARTHROPLASTY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 885–86. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1005.

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BackgroundWestern Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is commonly used in research studies of knee osteoarthritis (OA). It is commonly reported as ordinal raw scores. Previous validation studies using Rasch models requires item deletion. Conversion table to Interval scale for meaningful measurement is not available.ObjectivesWe aim to evaluate the fit of WOMAC to the Rasch model in a large sample of patients with knee OA who have undergone knee arthroplasty (KA) to derive the transformation table for interval scale measurement.MethodsWe used data collected from knee
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Vulpiani, Maria Chiara, Mario Vetrano, Sveva Maria Nusca, et al. "Hyaluronic acid alone versus hyaluronic acid associated with adelmidrol for Intra-articular treatment of knee osteoarthritis: A long-term follow-up." International Journal of Physiotherapy and Research 11, no. 1 (2023): 4453–60. http://dx.doi.org/10.16965/ijpr.2022.192.

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Background: Hyaluronic acid (HA) has been used for many years for intra-articular treatment of knee osteoarthritis with satisfactory results. HA associated with Adelmidrol – an anti-neuroinflammatory compound – have been only recently introduced in orthopedic clinical practice with good preliminary results. Objective: To investigate whether HA associated with Adelmidrol provides better results than HA alone. Methods: Two cohorts of patients with moderate knee osteoarthritis were treated. Cohort 1 received 5 weekly intra-articular injections of HA during 2017 while Cohort 2, 4 weekly intra-arti
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Panda, Sanjib kumar, Somashekara Nirvanashetty, Vivek A. Parachur, Nilima Mohanty, and Tathastu Swain. "A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OA." BioMed Research International 2018 (October 25, 2018): 1–8. http://dx.doi.org/10.1155/2018/5291945.

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Background. Curene® is a bioavailable formulation of turmeric Curcucma longa extract comprising naturally derived curcuminoids formulated with proprietary Aquasome® technology. Curcuminoids were found to have anti-inflammatory properties by inhibiting Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) enzyme and hence have potential application in the treatment of Osteoarthritis (OA). To evaluate the safety and efficacy of Curene® a randomized, double blind, placebo controlled, parallel-group study was conducted in subjects with knee OA. Significant improvements in clinical endpoints were obs
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Jubb, Ronald W., Emad S. Tukmachi, Peter W. Jones, Emma Dempsey, Lynn Waterhouse, and Sue Brailsford. "A Blinded Randomised Trial of Acupuncture (Manual and Electroacupuncture) Compared with a Non-Penetrating Sham for the Symptoms of Osteoarthritis of the Knee." Acupuncture in Medicine 26, no. 2 (2008): 69–78. http://dx.doi.org/10.1136/aim.26.2.69.

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Objectives To compare the effect of acupuncture (manual and electroacupuncture) with that of a non-penetrating sham (‘placebo’ needle) in patients with osteoarthritic knee pain and disability who are blind to the treatment allocation. Methods Acupuncture naive patients with symptomatic and radiological evidence of osteoarthritis of the knee were randomly allocated to a course of either acupuncture or non-penetrating sham acupuncture using a sheathed ‘placebo’ needle system. Acupuncture points for pain and stiffness were selected according to acupuncture theory for treating Bi syndrome. Both ma
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Kwoh, C. K., F. Roemer, A. Guermazi, and E. Ashbeck. "POS0108 WOMAC KNEE PAIN: DOES IT WALK THE WALK?" Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 268.2–268. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6224.

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BackgroundDue to its major public health impact, knee osteoarthritis (KOA) has been designated as a serious disease by the US Food and Drug Administration (FDA). Approval of a disease modifying osteoarthritis drug (DMOAD) to slow or prevent disease progression hinges on demonstrating both symptomatic (i.e., how a patient feels or functions) and structural improvement. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the questionnaire most commonly used to assess symptomatic improvement, may not adequately reflect pain reporting due to KOA. The lack of DMOAD approval
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Singh Nijjar, J., K. Abbott-Banner, R. Ray, et al. "OP0075 EFFICACY, SAFETY, PHARMACOKINETICS AND IMMUNOGENICITY OF REPEATED DOSING OF GSK3858279 IN PATIENTS WITH KNEE OSTEOARTHRITIS: A PHASE I, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 51–52. http://dx.doi.org/10.1136/annrheumdis-2023-eular.751.

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BackgroundChronic pain is an unmet need in osteoarthritis (OA) as current therapies have limited analgesia and side effects. The chemokine CCL17 mediates inflammatory pain and blocking CCL17 (via anti-CCL17 monoclonal antibodies [mAb] or CCL17 knock-out) reduces pain and joint disease in murine arthritis. GSK3858279 is a novel, high affinity, human mAb that functionally inhibits CCL17.ObjectivesTo present efficacy, safety, pharmacokinetic (PK) and immunogenicity data from Part B of a first-in-human, 2 part, phase I, randomized, double-blind, placebo (PBO)-controlled study evaluating GSK3858279
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Lam, Cindy, Weng Yee Chin, Carlos King Ho Wong, et al. "Effectiveness of routine measurement of health-related quality of life in improving the outcomes of patients with musculoskeletal problems—a cluster randomised controlled trial: protocol paper." BMJ Open 10, no. 12 (2020): e040373. http://dx.doi.org/10.1136/bmjopen-2020-040373.

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IntroductionManaging chronic musculoskeletal problems usually focuses on pain control using medications, but outcomes are often unsatisfactory and sometimes harmful. Information on a patient’s health-related quality of life (HRQOL) may trigger a doctor to tailor management improving quality of life. The aim of this trial is to find out whether routine measurement and reporting of a patient’s EuroQoL 5-Dimension 5-Level (EQ-5D-5L) HRQOL data using an electronic platform can improve HRQOL and pain in patients with chronic knee or back problems in primary care. We will also assess the acceptabili
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Lizaur-Utrilla, Alejandro, Francisco A. Miralles-Muñoz, Santiago Gonzalez-Parreño, and Fernando A. Lopez-Prats. "Outcomes and Patient Satisfaction With Arthroscopic Partial Meniscectomy for Degenerative and Traumatic Tears in Middle-Aged Patients With No or Mild Osteoarthritis." American Journal of Sports Medicine 47, no. 10 (2019): 2412–19. http://dx.doi.org/10.1177/0363546519857589.

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Background: There is controversy about the benefit of arthroscopic partial meniscectomy (APM) for degenerative lesions in middle-aged patients. Purpose: To compare satisfaction with APM between middle-aged patients with no or mild knee osteoarthritis (OA) and a degenerative meniscal tear and those with a traumatic tear. Study Design: Cohort study; Level of evidence, 2. Methods: A comparative prospective study at 5 years of middle-aged patients (45-60 years old) with no or mild OA undergoing APM for degenerative (n = 115) or traumatic (n = 143) tears was conducted. Patient satisfaction was meas
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Onu, Ilie, Daniela Matei, Dragos-Petrica Sardaru, et al. "Rehabilitation of Patients with Moderate Knee Osteoarthritis Using Hyaluronic Acid Viscosupplementation and Physiotherapy." Applied Sciences 12, no. 6 (2022): 3165. http://dx.doi.org/10.3390/app12063165.

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Knee osteoarthritis (KOA) is one of the most common public health problems which cannot be cured and ultimately leads to disability. Current management is largely limited to the treatment of the symptoms. To avoid the late stages of KOA that lead to knee replacement, the key point is to control and reduce destructive processes using efficient pharmacological products combined with physiotherapy (PT). Herein, we perform a monocentric observational study to compare the effect of combining a multi-modal physiotherapy regime and intra-articular (IA) injection with hyaluronic acid (HA) on the non-s
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Karaborklu Argut, S., D. Celik, O. Ergin, and O. Kilicoglu. "AB1178 THE COMPARISON OF PRP ALONE, SUPERVISED EXERCISE ALONE, AND PRP COMBINED WITH SUPERVISED EXERCISE IN MANAGEMENT OF KNEE OSTEOARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1818.1–1819. http://dx.doi.org/10.1136/annrheumdis-2023-eular.283.

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BackgroundPlatelet-rich plasma (PRP) has sparked widespread interest as a regenerative adjunct therapy, and it is increasingly being used to treat knee osteoarthritis (OA). There is a scarcity of reports on the characterization of injected products, as well as a scarcity of exercise protocols following PRP injections, despite the rising number of studies in the present PRP literature.ObjectivesThe purpose of this study was to compare the efficacy of PRP with a supervised exercise program and reveal if the combination of the two treatments is effective in the management of knee OA.MethodsThis i
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Usama, Bin Yar. "A Review: Effect of Whole Body Vibration on Parkinson Disease." IAR Journal of Engineering and Technology 2, no. 3 (2022): 8–14. https://doi.org/10.5281/zenodo.6220234.

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<strong>I</strong><strong>NTRODUCTION</strong> Parkinson&#39;s disease (PD) is a complicated, irreversible and debilitating neurodegenerative condition leading to progressive depletion of nigrostriary dopaminergic neurons leading to a loss of motor control (Hirsch, M. A., &amp; Farley, B. G. 2009). PD is composed of motor and non-motor signs and effects. The clinical phase of PD also continues with non-motor signs, and patients are not typically diagnosed at this stage of the disorder. Diagnosis happens when there are strong and noticeable motor signs, such as resting tremor, stiffness, weaken
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El-Kadiry, Abed El-Hakim, Carlos Lumbao, Natasha Salame, Moutih Rafei, and Riam Shammaa. "Bone marrow aspirate concentrate versus platelet-rich plasma for treating knee osteoarthritis: a one-year non-randomized retrospective comparative study." BMC Musculoskeletal Disorders 23, no. 1 (2022). http://dx.doi.org/10.1186/s12891-021-04910-5.

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Abstract Background Knee osteoarthritis (OA) is a debilitating condition affecting human body biomechanics and quality of life. Current standard care for knee OA leads to trivial improvement and entails multiple adverse effects or complications. Recently, investigational cell therapies injected intra-articularly, such as bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP), have shown safety and therapeutic potency providing patients with pain relief. In the current retrospective comparative study, we investigated the differences in pain and functional improvements in patient
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Fuchs, Sebastian, Lars Schwettmann, Benedict Katzenberger, et al. "Association of self-efficacy, risk attitudes, and time preferences with health-related quality of life and functioning after total hip or knee replacement – Results of the MobilE-TRA 2 cohort." Health and Quality of Life Outcomes 23, no. 1 (2025). https://doi.org/10.1186/s12955-025-02374-y.

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Abstract Background While total hip and knee replacement (THR/TKR) surgery are effective measures to restore functioning and reduce pain in patients with severe osteoarthritis (OA), long-term treatment effects vary among patients. Following behavioral economic theory, these differences may be partially attributed to the impact of personality traits on individual strategies to approach post-surgical challenges. This study explored the associations between self-efficacy, willingness to take risk regarding health (H-WTTR), and future orientation, and the 3-month course of health-related quality o
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Akgül, Hakan, Murat Birtane, and Eda Tonga. "Effects of a Digitally Supported Physical Activity Intervention in Knee Osteoarthritis: A Pilot Randomized Controlled Trial." Musculoskeletal Care 23, no. 2 (2025). https://doi.org/10.1002/msc.70085.

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ABSTRACTObjectivesThe aim of this study was to investigate the effects of a digitally supported physical activity (PA) intervention on pain, physical function, exercise adherence and quality of life in females with knee osteoarthritis (OA).MethodsThirty female participants with knee OA were randomly assigned to either a control group (n = 15) receiving patient education, smartwatch use, and a home exercise programme, or an intervention group (n = 15) receiving an additional digitally supported walking programme. The primary outcome measures were pain severity (Numerical Pain Rating Scale [NPRS
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Karaborklu Argut, Sezen, Derya Celik, Omer Naci Ergin, and Onder Ismet Kilicoglu. "Does the Combination of Platelet-rich Plasma and Supervised Exercise Yield Better Pain Relief and Enhanced Function in Knee Osteoarthritis? A Randomized Controlled Trial." Clinical Orthopaedics & Related Research, February 6, 2024. http://dx.doi.org/10.1097/corr.0000000000002993.

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Background Knee osteoarthritis is a leading cause of disability with substantial healthcare costs, and efficient nonsurgical treatment methods are still needed. Platelet-rich plasma (PRP) injections and exercise therapy are used frequently in clinical practice. Whether PRP or PRP combined with exercise is more effective than exercise alone is unclear. Questions/purposes (1) Which treatment relieves knee osteoarthritis pain better: PRP alone, exercise, or PRP combined with exercise? (2) Does PRP alone, exercise, or PRP combined with exercise yield better results in terms of the WOMAC score, per
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Berto, Patrizia, Maria Domenica Sanna, James Jackson, Mia Berry, and Jessica Jackson. "Osteoarthritis in Italy: Impact on Health-Related Quality of Life and Health Care Resources." Farmeconomia. Health economics and therapeutic pathways 22, no. 1 (2021). http://dx.doi.org/10.7175/fe.v22i1.1496.

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OBJECTIVE: To determine how osteoarthritis (OA) severity correlates with self-reported outcomes relevant from the patient’s perspective in the Italian clinical setting.METHODS: Data were drawn from the 2017-18 Adelphi OA Disease Specific ProgrammeTM (DSP). Data were collected in the Italian clinical practice settings by primary care physicians, rheumatologists, orthopedists, and their patients with OA, during their regular office visits. Physicians completed information about OA-related visits to healthcare professionals (HCPs), tests/scans conducted, emergency room (ER) visits, surgeries, and
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Langenberger, Benedikt, Viktoria Steinbeck, and Reinhard Busse. "Who Benefits From Hip Arthroplasty or Knee Arthroplasty? Preoperative Patient-reported Outcome Thresholds Predict Meaningful Improvement." Clinical Orthopaedics & Related Research, February 21, 2024. http://dx.doi.org/10.1097/corr.0000000000002994.

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Background Hip arthroplasty (HA) and knee arthroplasty (KA) are high-volume procedures. However, there is a debate about the quality of indication; that is, whether surgery is truly indicated in all patients. Patient-reported outcome measures (PROMs) may be used to determine preoperative thresholds to differentiate patients who will likely benefit from surgery from those who will not. Questions/purposes (1) What were the minimum clinically important differences (MCIDs) for three commonly used PROMs in a large population of patients undergoing HA or KA treated in a general orthopaedic practice?
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Negrini, Francesco, Francesco De Lucia, Stefano Negrini, et al. "Case Report: Rehabilitation After Platelet-Rich Growth Factors’ Intra-Articular Injections for Knee Osteoarthritis: Two Case Reports of a Home-Based Protocol." Frontiers in Pharmacology 12 (August 23, 2021). http://dx.doi.org/10.3389/fphar.2021.718060.

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Knee osteoarthritis (KOA) is a chronic progressive disease that can cause pain, functional impairment, and ultimately disability. A novel and promising therapeutic approach to KOA is the so-called regenerative medicine, a set of procedures designed to harness tissue regenerative capacity and optimize functional recovery. Increasing evidence points out that platelet-rich plasma (PRP) intra-articular injections can decrease pain and improve functional abilities in KOA patients. In the present case reports, we analyze two patients who were treated with PRP injections coupled with a posttreatment
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Doxey, Stephen, Fernando Huyke-Hernandez, Rebekah Kleinsmith, Bradley Nelson, and Brian Cunningham. "Poster 338: Minimum Clinically Important Difference (MCID) for Single Assessment Numeric Evaluation (SANE) after Anterior Cruciate Ligament Reconstruction: Determining a Successful Outcome." Orthopaedic Journal of Sports Medicine 12, no. 7_suppl2 (2024). http://dx.doi.org/10.1177/2325967124s00304.

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Objectives: Minimum clinically important difference (MCID) is a value that helps identify the patient-reported outcome measure (PROM) change deemed to be clinically meaningful to a patient. Although MCID values and PROMs are being increasingly used in the context of anterior cruciate ligament (ACL) reconstruction (ACLR) to determine treatment success and inform health policies, MCID values are subject to wide variation depending on the methodology used in the calculation. The anchor-based method determines the change in PROM associated with the smallest detectable improvement of another measur
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Bossen, Jeroen Klaas Jacobus, Julia Aline Wesselink, Ide Christiaan Heyligers, and Jesse Jansen. "Implementation of a Decision Aid for Hip and Knee Osteoarthritis in Orthopedics: A Mixed-Methods Process Evaluation." Medical Decision Making, October 30, 2023. http://dx.doi.org/10.1177/0272989x231205858.

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Background In orthopedics, the use of patient decision aids (ptDAs) is limited. With a mixed-method process evaluation, we investigated patient factors associated with accepting versus declining the use of the ptDA, patients’ reasons for declining the ptDA, and clinicians’ perceived barriers and facilitators for its use. Methods Patients with an indication for joint replacement surgery ( N = 153) completed questionnaires measuring demographics, physical functioning, quality of life (EQ-5D-3L), and a visual analog scale (VAS) pain score at 1 time point. Subsequently, their clinician offered the
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