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1

Slavković, Damjan, Zoran Kostić, Nikolina Milošević, et al. "Surgical wound infiltration by local anesthetic: Wound infiltration." Serbian Journal of Anesthesia and Intensive Therapy 41, no. 7-8 (2019): 143–55. http://dx.doi.org/10.5937/sjait1908143s.

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Scott, N. B. "Wound infiltration for surgery." Anaesthesia 65 (April 2010): 67–75. http://dx.doi.org/10.1111/j.1365-2044.2010.06241.x.

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Notcutt, W. G. "Wound infiltration and Caesarean section." Anaesthesia 46, no. 11 (1991): 999. http://dx.doi.org/10.1111/j.1365-2044.1991.tb09900.x.

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Trotter, Timothy N., and Jeremy A. Langton. "Wound Infiltration and Inguinal Herniorrhaphy." Anesthesia & Analgesia 71, no. 3 (1990): 310. http://dx.doi.org/10.1213/00000539-199009000-00024.

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Kissin, Igor. "Wound Infiltration and Inguinal Herniorrhaphy." Anesthesia & Analgesia 71, no. 3 (1990): 310???311. http://dx.doi.org/10.1213/00000539-199009000-00025.

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RENCK, H. "Wound infiltration with local anaesthetics." Acta Anaesthesiologica Scandinavica 38, no. 1 (1994): 2–6. http://dx.doi.org/10.1111/j.1399-6576.1994.tb03829.x.

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Bhargava, Pranshu, Nidhi Mehrotra, and Ajay Kumar. "Wound infection after metronidazole infiltration." Tropical Doctor 36, no. 1 (2006): 37–38. http://dx.doi.org/10.1258/004947506775598923.

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Bai, Johnny Wei, Dong An, Anahi Perlas, and Vincent Chan. "Adjuncts to local anesthetic wound infiltration for postoperative analgesia: a systematic review." Regional Anesthesia & Pain Medicine 45, no. 8 (2020): 645–55. http://dx.doi.org/10.1136/rapm-2020-101593.

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Local anesthetics (LAs) are commonly infiltrated into surgical wounds for postsurgical analgesia. While many adjuncts to LA agents have been studied, it is unclear which adjuncts are most effective for co-infiltration to improve and prolong analgesia. We performed a systematic review on adjuncts (excluding epinephrine) to local infiltrative anesthesia to determine their analgesic efficacy and opioid-sparing properties. Multiple databases were searched up to December 2019 for randomized controlled trials (RCTs) and two reviewers independently performed title/abstract screening and full-text rev
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9

Su, Yingjun, and Ann Richmond. "Chemokine Regulation of Neutrophil Infiltration of Skin Wounds." Advances in Wound Care 4, no. 11 (2015): 631–40. http://dx.doi.org/10.1089/wound.2014.0559.

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&NA;. "Preoperative wound infiltration with bupivacaine helpful." Inpharma Weekly &NA;, no. 1053 (1996): 17. http://dx.doi.org/10.2165/00128413-199610530-00036.

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Kostic, Tamara, and Suzana Bojic. "Modified intermittent subfascial wound infiltration with local anaesthetic after open gastric bypass (wound infiltration aftrer gastric bypass)." Serbian Journal of Anesthesia and Intensive Therapy 39, no. 5-6 (2017): 81–85. http://dx.doi.org/10.5937/sjait1704081k.

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12

Jukic, Aleksandra. "Intraoperative wound infiltration with local anesthetic in open abdominal hysterectomy significantly reduces postoperative opioid consumption (wound infiltration)." Serbian Journal of Anesthesia and Intensive Therapy 39, no. 5-6 (2017): 133–37. http://dx.doi.org/10.5937/sjait1706133j.

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13

Adjinegoro, Lahuda, Sahudi, and Husnul Ghaib. "Infiltration effect of ropivacaine on skin wound healing assessed by collagen density." Bali Medical Journal 13, no. 2 (2024): 691–93. https://doi.org/10.15562/bmj.v13i2.4895.

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Link of Video Abstract: https://youtu.be/juiwFS3TxfA Introduction: The wound healing process is characterized by granulation tissue rich in new blood vessel networks and macrophages, granulocytes, endothelial cells, and collagen that fill the wound gap. Ropivacaine infiltration, which can be used as a long-acting local anesthetic, is expected to reduce surgical stress. One of the parameters that can be used to assess wound healing is collagen density. Thus, it needs to be determined whether there are differences in the administration of ropivacaine as a local anesthetic in supporting the impro
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14

Subiantoro, Andri, Arie Utariani, and Imam Susilo. "Expression of Vascular Endothelial Growth Factor (VEGF) and New Blood Vessels Formation on Wound Incision Post Ropivacaine Administration in Animal Model." International Journal of Innovative Science and Research Technology 5, no. 7 (2020): 829–36. http://dx.doi.org/10.38124/ijisrt20jul550.

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Surgical incision wounds causing clinical pain. Inadequate postoperative pain management resulting in impaired wound healing. A critical factor in wound healing is angiogenesis. VEGF is one of the important factors and regulators of angiogenesis. The aim of this study is to analyze the effect of infiltration ropivacaine on VEGF expression, and the formation of new blood vessels, which is very instrumental in the wound healing process. Methods: Twenty-four Wistar rats were divided into two groups, and then superficial-thickness excisional wounds were created. One was treated by ropivacaine infi
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15

Dahl, Jørgen B., and Hans J. Frederiksen. "Wound infiltration for operative and postoperative analgesia." Current Opinion in Anaesthesiology 8, no. 5 (1995): 435–40. http://dx.doi.org/10.1097/00001503-199510000-00013.

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16

Scott, Nick B. "Wound Infiltration—Apples, Oranges, or Fruit Cocktail?" Regional Anesthesia and Pain Medicine 37, no. 2 (2012): 233. http://dx.doi.org/10.1097/aap.0b013e318240637c.

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Braito, Matthias, Dietmar Dammerer, Andreas Schlager, Jürgen Wansch, Caroline Linhart, and Rainer Biedermann. "Continuous Wound Infiltration After Hallux Valgus Surgery." Foot & Ankle International 39, no. 2 (2017): 180–88. http://dx.doi.org/10.1177/1071100717736292.

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Background: Hallux valgus surgery is associated with significant early postoperative pain. The aim of this study was to investigate the use of continuous wound infiltration (CWI) with ropivacaine for pain management after hallux valgus surgery. Methods: In this prospective, randomized, double-blind, and placebo-controlled single-center trial, 50 patients undergoing distal metatarsal osteotomy for idiopathic hallux valgus were allocated to CWI with ropivacaine 2 mg/mL at a rate of 2 mL/h or placebo for 24 hours postoperatively. Average and peak pain levels on the verbal numeric rating scale (NR
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18

Mulroy, M. F., F. W. Burgess, R. L. Carpenter, B. M. Emanuelsson, and C. A. Stephenson. "Ropivacaine for Postoperative Wound Infiltration after Herniorrhaphy." Anesthesiology 81, SUPPLEMENT (1994): A1015. http://dx.doi.org/10.1097/00000542-199409001-01014.

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Stringer, Bruce W., Aloke K. Singhania, Joe E. Sudhakar, and Rodney B. Brink. "Serum and Wound Drain Ropivacaine Concentrations After Wound Infiltration in Joint Arthroplasty." Journal of Arthroplasty 22, no. 6 (2007): 884–92. http://dx.doi.org/10.1016/j.arth.2006.09.004.

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HOTTA, Kunihisa, Soichiro INOUE, Koki TAIRA, Naho SATA, Kenji TAMAI, and Mamoru TAKEUCHI. "Continuous Wound Infiltration in Patients Undergoing Gynecologic Laparotomy." JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 34, no. 2 (2014): 198–202. http://dx.doi.org/10.2199/jjsca.34.198.

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21

Bliggenstorfer, Jonathan, and Emily Steinhagen. "Regional anesthesia: Epidurals, TAP blocks, or wound infiltration?" Seminars in Colon and Rectal Surgery 32, no. 3 (2021): 100831. http://dx.doi.org/10.1016/j.scrs.2021.100831.

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22

Horn, E.-P., F. Schroeder, H.-J. Bartz, D. I. Sessler, B. Uebe, and Th Standl. "Wound Infiltration with Ropivacaine after Major Shoulder Surgery." Regional Anesthesia and Pain Medicine 23, Sup 1 (1998): 63. http://dx.doi.org/10.1097/00115550-199823031-00063.

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Adesope, Oluwaseyi, Unyime Ituk, and Ashraf S. Habib. "Local anaesthetic wound infiltration for postcaesarean section analgesia." European Journal of Anaesthesiology 33, no. 10 (2016): 731–42. http://dx.doi.org/10.1097/eja.0000000000000462.

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Estebe, Jean-Pierre Ch, Pascal Le Corre, François Chevanne, Rozen Clement, and Claude Ecoffey. "Wound Infiltration of Iliac Bone Craft Harvest Site." Anesthesiology 96, Sup 2 (2002): A936. http://dx.doi.org/10.1097/00000542-200209002-00936.

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Adesope, O., U. Ituk, and A. S. Habib. "Local Anaesthetic Wound Infiltration for Postcaesarean Section Analgesia." Survey of Anesthesiology 61, no. 1 (2017): 12–13. http://dx.doi.org/10.1097/01.sa.0000513493.87398.bc.

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Cherian, Meena N., Mohan P. Mathews, and Mathew J. Chandy. "Local wound infiltration with bupivacaine in lumbar laminectomy." Surgical Neurology 47, no. 2 (1997): 120–22. http://dx.doi.org/10.1016/s0090-3019(96)00255-8.

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Hadri, B., L. Emini, I. Arifaj, and I. Krasniqi. "Post thyroidectomy wound infiltration for postoperative pain relief." European Journal of Anaesthesiology 31 (June 2014): 229. http://dx.doi.org/10.1097/00003643-201406001-00660.

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Cobby, T. F., and M. F. Reid. "Wound infiltration with local anaesthetic after abdominal hysterectomy." British Journal of Anaesthesia 78, no. 4 (1997): 431–32. http://dx.doi.org/10.1093/bja/78.4.431.

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29

Gupta, Anil. "Wound infiltration with local anaesthetics in ambulatory surgery." Current Opinion in Anaesthesiology 23, no. 6 (2010): 708–13. http://dx.doi.org/10.1097/aco.0b013e32833f0dd7.

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Pedrazzani, Corrado, Nicola Menestrina, Margherita Moro, et al. "Local wound infiltration plus transversus abdominis plane (TAP) block versus local wound infiltration in laparoscopic colorectal surgery and ERAS program." Surgical Endoscopy 30, no. 11 (2016): 5117–25. http://dx.doi.org/10.1007/s00464-016-4862-5.

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Jameson, Julie M., Gabrielle Cauvi, Leslie L. Sharp, Deborah A. Witherden та Wendy L. Havran. "γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation". Journal of Experimental Medicine 201, № 8 (2005): 1269–79. http://dx.doi.org/10.1084/jem.20042057.

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Nonhealing wounds are a major complication of diseases such as diabetes and rheumatoid arthritis. For efficient tissue repair, inflammatory cells must infiltrate into the damaged tissue to orchestrate wound closure. Hyaluronan is involved in the inflammation associated with wound repair and binds the surface of leukocytes infiltrating damaged sites. Skin γδ T cells play specialized roles in keratinocyte proliferation during wound repair. Here, we show that γδ T cells are required for hyaluronan deposition in the extracellular matrix (ECM) and subsequent macrophage infiltration into wound sites
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32

Katherine, Inomy Claudia, Sahudi, and Husnul Ghaib. "Effect of Ropivacaine Subcutaneous Infiltration on Surgical Skin Defects." Bali Medical Journal 13, no. 3 (2024): 972–74. https://doi.org/10.15562/bmj.v13i3.5102.

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Background: Pain and the process of post-operative wound recovery are potential complications of surgery. No scientific evidence supports the claim that ropivacaine's infiltration effect on wound healing stimulates fibroblasts during the healing process and has an anti-inflammatory effect. This research aims to investigate the impact of ropivacaine infiltration on wound healing in experimental Wistar rats by quantifying fibroblasts. Methods: This study was an experimental study using a sample of 32 Wistar rats (Rattus norvegicus), which were randomly divided into two groups, namely the treatme
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33

G., Selvaraju, Nedumaran V., and G. Shanmugavelu. "A comparative study of postoperative analgesic efficacy between TAP block with wound infiltration in open gynaecological surgeries." International Journal of Research in Medical Sciences 6, no. 3 (2018): 889. http://dx.doi.org/10.18203/2320-6012.ijrms20180609.

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Background: Gynaecological surgeries are performed by abdominal incision is common and post-operative pain and discomfort is always anticipated. TAP block is a regional anaesthetic technique which blocks the abdominal neural afferents by administrating local anaesthetic drugs into the neuro-fascial plane. The other method for postoperative analgesia is surgical wound infiltration with local anaesthetic drugs. The aim of this study was to evaluate the post-operative analgesic efficacy of TAP block versus wound infiltration in gynaecological surgeries.Methods: The study was a prospective randomi
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34

Pollack, Bracha L., Jeremy S. Torrisi, Geoffrey E. Hespe, et al. "Inhibition of Th2 Differentiation Accelerates Chronic Wound Healing by Facilitating Lymphangiogenesis." Biomedicines 13, no. 5 (2025): 1026. https://doi.org/10.3390/biomedicines13051026.

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Background/Objectives: Chronic wounds pose a significant healthcare burden, and there remains no effective animal model for study. We aimed to develop a mouse model of chronic wounds that remain open for at least 4 weeks and to investigate the role of the lymphatic system in wound healing. Methods: Full-thickness excisional wounds were created on the dorsal surface of mouse tails to simulate chronic wounds. Lymphatic drainage was assessed using FITC–dextran lymphangiography. Histology and immunofluorescence were used to analyze immune cell infiltration. The effect of inhibiting Th2 differentia
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Szymanski, Lukasz, Sławomir Lewicki, Tomasz Markiewicz, Szczepan Cierniak, Jean-Pierre Tassan, and Jacek Z. Kubiak. "siRNA-Mediated MELK Knockdown Induces Accelerated Wound Healing with Increased Collagen Deposition." International Journal of Molecular Sciences 24, no. 2 (2023): 1326. http://dx.doi.org/10.3390/ijms24021326.

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Skin wounds remain a significant problem for the healthcare system, affecting the clinical outcome, patients’ quality of life, and financial costs. Reduced wound healing times would improve clinical, economic, and social aspects for both patients and the healthcare system. Skin wound healing has been studied for years, but effective therapy that leads to accelerated wound healing remains to be discovered. This study aimed to evaluate the potential of MELK silencing to accelerate wound healing. A vectorless, transient knockdown of the MELK gene using siRNA was performed in a murine skin wound m
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Lee, Hye Mi, Eun Jung Jang, Ki Hun Choi, and Young Cheon Na. "Comparative evaluation of hyaluronic acid-based dressing versus hydrocolloid dressing in rat dermal wound healing." Archives of Craniofacial Surgery 25, no. 5 (2024): 224–29. http://dx.doi.org/10.7181/acfs.2024.00381.

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Background: Wound healing is a complex process influenced by a variety of environmental factors. Dressing materials play a critical role in creating barriers against contaminants, maintaining optimal moisture levels, and absorbing wound exudate. Therefore, selecting materials tailored to wound characteristics is crucial for enhancing outcomes. Hyaluronic acid (HA) is a natural biocompatible polymer that supports healing by regulating inflammation and promoting tissue repair. This study compared HA- and hydrocolloid-based hydrogels in a rat model to optimize wound care strategies.Methods: Full-
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Laskou, Stiliani, Georgia Tsaousi, Chryssa Pourzitaki, et al. "Local Wound Infiltration for Thyroidectomized Patients in the Era of Multimodal Analgesia." Medicina 59, no. 9 (2023): 1662. http://dx.doi.org/10.3390/medicina59091662.

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The first few hours following thyroidectomy are the most crucial for pain management. Adequate postoperative pain control, reduction in opioid abuse and the possibility of implementing one-day operations are the considered parameters when developing the postoperative analgesic strategy. A study of the available literature was conducted, exploring the efficacy of (open) thyroidectomy wound infiltration. Seventeen full-text RCTs were extracted. Local anesthetics and non-steroidal anti-inflammatory drugs were infiltrated. Emphasis was given to postoperative pain scores and requirements for rescue
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DAHL, J. B., S. MØINICHE, and H. KEHLET. "Wound infiltration with local anaesthetics for postoperative pain relief." Acta Anaesthesiologica Scandinavica 38, no. 1 (1994): 7–14. http://dx.doi.org/10.1111/j.1399-6576.1994.tb03830.x.

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Brower, Marc C., and Michael E. Johnson. "Adverse Effects of Local Anesthetic Infiltration on Wound Healing." Regional Anesthesia and Pain Medicine 28, no. 3 (2003): 233–40. http://dx.doi.org/10.1097/00115550-200305000-00011.

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GRANT, G. J., J. LAX, L. SUSSER, M. ZAKOWSKI, and E. WEISSMAN. "Wound infiltration with liposomal bupivacaine prolongs analgesia in rats." Acta Anaesthesiologica Scandinavica 41, no. 2 (1997): 204–7. http://dx.doi.org/10.1111/j.1399-6576.1997.tb04666.x.

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Brower, M. "Adverse effects of local anesthetic infiltration on wound healing." Regional Anesthesia and Pain Medicine 28, no. 3 (2003): 233–40. http://dx.doi.org/10.1053/rapm.2003.50050.

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Castro-Alves, Lucas, and Mark C. Kendall. "The Evidence for Ropivacaine Wound Infiltration and Postsurgical Pain." Journal of Surgical Research 237 (May 2019): 93. http://dx.doi.org/10.1016/j.jss.2018.02.007.

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Horn, E.-P., F. Schroeder, S. Wilhelm, et al. "Ropivacaine Wound Infiltration In Patients Following Major Shoulder Surgery." Anesthesiology 89, Supplement (1998): 878A. http://dx.doi.org/10.1097/00000542-199809150-00053.

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Lan‐Pak‐Kee, V., T. Egan, T. Tarrell, and T. Konig. "Continuous local anaesthetic wound catheter infiltration after clamshell thoracotomy." Anaesthesia Reports 7, no. 1 (2019): 29–31. http://dx.doi.org/10.1002/anr3.12010.

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PUN, W. K., S. P. CHOW, K. D. K. LUK, Y. C. SO, F. K. IP, and K. C. CHAN. "Sequential Forearm Intravenous Regional and Infiltration Anaesthesia: Value for Haemostasis." Journal of Hand Surgery 15, no. 1 (1990): 115–17. http://dx.doi.org/10.1016/0266-7681_90_90065-c.

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Intravenous regional anaesthesia using 0.5% lignocaine with a forearm tourniquet is a satisfactory technique for operations on the distal forearm, wrist and hand. Since recovery of pain sensation is rapid, haemostasis after release of tourniquet becomes difficult and sometimes impossible. Local wound infiltration or metacarpal block with 1% lignocaine just before release of the tourniquet can allow subsequent haemostasis and wound closure to be carried out without causing pain. 55 patients received this sequential forearm intravenous regional and infiltrative anaesthesia. Subsequent haemostasi
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Cheng, Yu-Hsuan, Hung-Keng Li, Chien-An Yao, et al. "Negative air ions through the action of antioxidation, anti-inflammation, anti-apoptosis and angiogenesis ameliorate lipopolysaccharide induced acute lung injury and promote diabetic wound healing in rat." PLOS ONE 17, no. 10 (2022): e0275748. http://dx.doi.org/10.1371/journal.pone.0275748.

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Negative air ions (NAIs) being bioactive and negative charged molecules may confer antioxidant and anti-inflammatory activity. We assessed the effect of NAIs on two inflammatory diseases in animal models including lipopolysaccharide (LPS) induced acute lung injury (ALI) and wound healing in diabetic rats. We used intra-tracheal infusion of LPS to induce ALI and made a full-thickness cutaneous wound in streptozotocin-induced diabetic female Wistar rats. We evaluated NAIs effects on reactive oxygen species amount, leukocyte infiltration, wound healing rate, western blot, and immunohistochemistry
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47

Lee, Yoonje, Sanjaya Ricky, Tae Ho Lim, et al. "Wound Healing Effect of Nonthermal Atmospheric Pressure Plasma Jet on a Rat Burn Wound Model: A Preliminary Study." Journal of Burn Care & Research 40, no. 6 (2019): 923–29. http://dx.doi.org/10.1093/jbcr/irz120.

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Abstract Worldwide, an estimated 6 million patients seek medical attention for burns annually. Various treatment methods and materials have been investigated and developed to enhance burn wound healing. Recently, a new technology, plasma medicine, has emerged to offer new solutions in wound care. As the development of plasma medicine has shown benefit in wound healing, we aimed to assess the effects of plasma medicine on burn wounds. To investigate the effectiveness of a nonthermal atmospheric pressure plasma jet (NAPPJ) for burn wound treatment on a brass comb burn wound rat model. Burn wound
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48

Konop, Marek, Anna K. Laskowska, Mateusz Rybka, et al. "Keratin Scaffolds Containing Casomorphin Stimulate Macrophage Infiltration and Accelerate Full-Thickness Cutaneous Wound Healing in Diabetic Mice." Molecules 26, no. 9 (2021): 2554. http://dx.doi.org/10.3390/molecules26092554.

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Impaired wound healing is a major medical challenge, especially in diabetics. Over the centuries, the main goal of tissue engineering and regenerative medicine has been to invent biomaterials that accelerate the wound healing process. In this context, keratin-derived biomaterial is a promising candidate due to its biocompatibility and biodegradability. In this study, we evaluated an insoluble fraction of keratin containing casomorphin as a wound dressing in a full-thickness surgical skin wound model in mice (n = 20) with iatrogenically induced diabetes. Casomorphin, an opioid peptide with anal
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49

S., Sudhir, and Kanmani G. Telkar. "A study of the wound performance following subcutaneous infiltration and topical instillation of ceftriaxone before primary closure of skin in laparotomy for peritonitis due to non-traumatic perforation of small intestine." International Surgery Journal 4, no. 12 (2017): 3956. http://dx.doi.org/10.18203/2349-2902.isj20175150.

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Background: Surgical site infection (SSI) continues to be a baffling problem since time immemorial. It is one of the major causes for postoperative morbidity and mortality. Many methods have been evolved to combat wound infection, but the rate of wound infection has been more or less static over past few years. The search for alternative modes of management is going on and one of the methods is intra incisional subcutaneous infiltration of antibiotics.Methods: This is a prospective study comprising of control and study groups of 25 patients each. Control group patients did not receive subcutan
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Glavas Tahtler, Josipa, Dajana Djapic, Marina Neferanovic, et al. "Long-Term Outcomes of Breast Cancer Patients Receiving Levobupivacaine Wound Infiltration or Diclofenac for Postoperative Pain Relief." Pharmaceutics 15, no. 9 (2023): 2183. http://dx.doi.org/10.3390/pharmaceutics15092183.

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Breast cancer is the most common malignant disease in women. Preclinical studies have confirmed that the local anesthetic levobupivacaine has a cytotoxic effect on breast cancer cells. We examined whether postoperative wound infiltration with levobupivacaine influences survival in 120 patients who were operated on for breast cancer and underwent quadrantectomy or mastectomy with axillary lymph node dissection. Groups with continuous levobupivacaine wound infiltration, bolus wound infiltration, and diclofenac analgesia were compared. Long-term outcomes examined were quality of life, shoulder di
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