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Rozprawy doktorskie na temat „Xanthines”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Riche, Christian. "Xanthines : approches analytique, clinique, métabolique." Besançon, 1988. http://www.theses.fr/1988BESAA001.

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A partir de techniques de dosage des bases xanthiques par chromatographie en phase gazeuse, sur colonne capillaire de verre, avec détection thermoionique, et par chromatographie liquide de haute performance sur colonne C18, utilisant un gradient de solvant, sont abordés des problèmes de pharmacologie clinique et de métabolisme in vivo et in vitro. L'utilisation de la théophylline et de la caféine dans le cadre du traitement des apnées du nouveau-né est étudiée. Deux expérimentations cliniques, destinées à déterminer la zone thérapeutique de la théophylline et de la caféine sont rapportées. Le

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2

Perticarari, Sofia. "Atropisomeric xanthines: Synthesis, stereodynamics and absolute configuration." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9025/.

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During the thesis period a new class of atropisomeric xanthine derivatives has been studied. We decided to focus our attention on these purine bases because of their various biological activities, that could play an important role in the discovery of new bioactive atropisomers. The synthesized compounds bear an Aryl-N chiral axis in position 1 of the xanthine scaffold, around which the rotation is prevented by the presence of bulky ortho substituents. Through a retro synthetic analysis we synthesized three atropisomeric structures bearing in position 1 of the purine scaffold respectively an o-

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3

Beauglehole, Anthony Robert, and anthony@adenrx com. "N3-substituted xanthines as irreversible adenosine receptor antagonists." Deakin University. School of Biological and Chemical Sciences, 2000. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20080612.084330.

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8-Cyclopentyl-3-(3-(4-fluorosulfonylbenzoyl)oxy)propyl-propylxanthine (44, FSCPX) has been reported to exhibit potent and selective irreversible antagonism of the A1 adenosine receptor when using in vitro biological preparations. However, FSCPX (44) suffers from cleavage of the ester linkage separating the reactive 4-(fluorosulfonyl)phenyl moiety from the xanthine pharmacophore when used in in vivo biological preparations or preparations containing significant enzyme activity, presumably by esterases. Cleavage

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4

Duckworth, Megan Jane Medical Sciences Faculty of Medicine UNSW. "Characterisation of the xanthineguanine phosphoribosyltransferase of helicobacter pylori as a potential therapeutic target." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/43418.

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Helicobacter pylori infects more than half of the global population and causes gastric disorders. The increasing development of antibiotic resistance by the bacterium continues to limit treatment options. The identification and characterisation of novel therapeutic targets are necessary for successful future treatment of the infection. One potential target for therapeutic intervention is the gpt gene encoded by hp0735 (jhp0672) in H. pylori strain 26695 (J99). This gene produces a putative xanthine-guanine phosphoribosyltransferase (XGPRTase), an enzyme of the purine salvage synthesis pathway

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5

Kascatan, Nebioglu Aysegul. "N-HETEROCYCLIC CARBENE SILVER(I) COMPLEXES FROM XANTHINES AND THEIR ANTIMICROBIAL APPLICATIONS." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1176579309.

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6

Massip, Stéphane. "Synthèse de nouvelles xanthines, dérivées de 2-amino-2-oxazolines, antagonistes potentiels des récepteurs de l'adenosine." Bordeaux 2, 2005. http://www.theses.fr/2005BOR21206.

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Ce travail de thèse nous a permis de synthétiser un grand nombre de nouveaux dérivés de type 1- ou 3-[2-hydroxy-3-aryloxypropyl]xanthines. Ces composés ont été obtenus à partir d'un synthon original de type amidine, les 2-amino-2-oxazolines. Les différentes voies réaxtionnelles nous ont conduit à des diaminouraciles intermédiaires diversement substitués dont les possibilités réactionnelles nous ont permis l'accès à plus de 60 nouvelles xanthines et analogues. Différentes stratégies de synthèse ont été développées pour accéder à de nouvelles xanthines 3 différemment substituées en position 1 et

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7

Seddon, Gavin M. "Radiation effects on biochemical systems." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313912.

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8

Mapengo, Raphaël. "Cinétiques de méthylation et de deutérométhylation des xanthines : évaluation des effets isotopiques : essai de corrélation aux réactions de N-déméthylation biologique." Lyon 1, 1990. http://www.theses.fr/1990LYO1T168.

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9

Calenzo, Chappe Valérie (19. "Régulation et pharmacologie du canal chlorure CFTR : implication des récepteurs purinergiques de type P2Y dans l'activation du canal CFTR par les dérivés xanthines." Aix-Marseille 1, 1999. http://www.theses.fr/1999AIX11026.

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Les epitheliums forment une barriere continue entre deux compartiments et permettent le transport d'ions, de solutes et de macromolecules. L'absorption de na + et la secretion de cl sont des elements majeurs de la fonction epitheliale. Le canal cftr (cystic fibrosis transmembrane conductance regulator), membre de la superfamille des transporteurs abc (atp binding cassette), est une des clefs de la regulation du transport de chlorure dans les epitheliums. La mucoviscidose est la maladie genetique la plus repandue dans les populations europeennes et nord-americaines. Elle se caracterise par une

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10

Essandoh, Ernest. "Structural studies of organic crystals of pharmaceutical relevance : correlation of crystal structure analysis with recognised non-bonded structural motifs in the organic solid state." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4444.

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Pharmaceutical solids tend to exist in different physical forms termed as polymorphs. Issues about pharmaceutical systems are mainly concerned with the active ingredient's physico-chemical stability and bioavailability. The main aim of this study is to investigate the non-bonded interactions in pharmaceutical solids that govern the physical pharmaceutics performance of such materials and through the use of structural techniques and correlation of these results with crystal structural database to establish the presence of physical motifs in selected systems. Structural motifs were identified by

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11

Lira, Eduardo Carvalho. "Efeito anticatabólico dos derivados de xantina no metabolismo de proteínas em músculos esqueléticos de ratos sépticos: um estudo de microdiálise." Faculdade de Medicina de São José do Rio Preto, 2006. http://bdtd.famerp.br/handle/tede/223.

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Made available in DSpace on 2016-01-26T12:51:51Z (GMT). No. of bitstreams: 1 eduardolira_dissert.pdf: 542986 bytes, checksum: e47b365af35f88f462e77e2e9ac92c97 (MD5) Previous issue date: 2006-04-20<br>Introduction: The aim of the present study was to estimate the anticatabolic effect of xanthine derivatives on skeletal muscle protein metabolism from septic rats by using microdialysis. Methods: Sepsis was induced by cecal ligation and puncture (CLP). After 3, 6 and 10 hours of surgery, male Wistar rats (~250g) were anesthetized with thionembutal sodium (50mg/Kg body weight i.p.) and placed on

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12

Stockert, Amy L. "Spectroscopic and kinetic studies of bovine xanthine oxidase and Rhodobacter capsulatus xanthine dehydrogenase." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1089910515.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 172 p.; also includes graphics. Includes bibliographical references (p. 165-172).

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13

Fujisawa(Morita), Yukari. "Identification of xanthine dehydrogenase/xanthine oxidase as a rat Paneth cell zinc-binding protein." Kyoto University, 2001. http://hdl.handle.net/2433/150188.

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14

Wilson, Wendy Lee. "Xanthine oxidase in the lung." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26669.

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The generation of oxygen free radicals by the cytosolic enzyme, xanthine oxidase (XO), has been implicated in post-ischemic or reperfusion damage in several organs. XO catalyzes the conversion of hypoxanthine to urate with the concomitant production of superoxide anion free radical (0₂̅˙) and hydrogen peroxide (H₂O₂). Oxygen free radical-mediated injury has also been demonstrated in inflammatory lung disease. The possible involvement of XO in oxidative injury in the lung has not yet been studied. Therefore, this research project was designed to determine whether XO is present in the lung and

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15

Gibson, Elizabeth. "Porphyrin probes for xanthine oxidase." Thesis, University of York, 2007. http://etheses.whiterose.ac.uk/9915/.

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16

Martin, Hannah M. "Cellular expression of xanthine oxidoreductase." Thesis, University of Bath, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426176.

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17

Wang, Jinfang. "Xanthine-imprinted polymers for decaffeination applications." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431777.

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18

Pauff, James Michael. "Structure-Function Studies of Xanthine Oxidoreductase." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1227480976.

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19

Leigh, Maria. "Non purine inhibitors of xanthine oxidase." Thesis, University of York, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550273.

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The increase in the occurrence of hyperuricemia and gout in recent years, coupled with side- effects associated with use of the main anti-gout therapeutic, allopurinol, have triggered the search for non-purine alternatives. The first such inhibitor to be made available is Adenurlc", 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid. The aim of this work was to synthesise a small library of non-purine compounds and evaluate their inhibitory activity against the enzyme, xanthine oxidase. Successful inhibitors are marked as those that gave a comparable or lower ICso value than allo

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20

Hewinson, James. "Vascular endothelial release of xanthine oxidoreductase." Thesis, University of Bath, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418883.

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21

Khan, Jamshad. "Purification and stability of bovine xanthine oxidase." Thesis, University of Bath, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307127.

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22

Bryant, Richard. "The immunoaffinity purification of human xanthine oxidase." Thesis, University of Bath, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398413.

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23

Rouquette, Magali. "Xanthine oxidoreductase : a role in cell signalling." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300878.

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24

Page, Susanna. "Regulation and immunolocalisation of human xanthine oxidoreductase." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300881.

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25

Powell, Debbie. "Purification, characterisation and regulation of human xanthine oxidase." Thesis, University of Bath, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307028.

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26

Choudhury, Sharmila. "Purification and characterisation of xanthine oxidoreductase from liver." Thesis, University of Bath, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760763.

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27

Lates, Vasilica-Adriana. "Systèmes bioanalytiques pour la détermination de la capacité antioxydante et l’ochratoxine A dans les denrées alimentaires." Perpignan, 2011. http://www.theses.fr/2011PERP1054.

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L'apport journalier en antioxydants (composés chimiques naturellement présents dans certains aliments) contribue à la diminution du stress oxydatif sur le métabolisme humain. Nous avons mis au point un nouvel outil pour la détermination de la capacité antioxydante, basé sur une série des réactions enzymatiques qui se déroulent dans un bioréacteur dont le produit principal, l’eau oxygénée, est suivi en temps réel par un biocapteur ampérométrique. Ce système analytique s'avère beaucoup plus adéquat pour l’analyse des échantillons réels que d’autres variantes déjà connues. La présence des mycotox

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28

Godber, Benjamin L. J. "Physicochemical and kinetic properties of human milk xanthine oxidoreductase." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760718.

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29

Al-Gonaiah, Majed A. "Investigating xanthine oxidase toxicity models in cultured cerebellar granule neurons." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1057/.

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In the last few decades, evidence has been accumulating for a role for xanthine oxidoreductase (XOR)-generated toxic reactive oxygen species (ROS) in a variety of pathological conditions that affect different organ systems. This enzyme in mammals exists in two inter-convertible forms: xanthine dehydrogenase (XDH) (the predominant intracellular form under physiological conditions) and xanthine oxidase (XO). A combination of XO and its oxidizable substrate xanthine (X) (or hypoxanthine (HX)) is widely used as a model to produce ROS and to study their effects in a variety of cell culture studies.

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30

Doyle, Wendy Anne. "Biochemical and molecular genetic studies of Drosophila melanogaster xanthine dehydrogenase." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239022.

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31

Millar, Timothy Marc. "Novel aspects of the activity and function of xanthine oxidase." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311326.

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32

Urso, Edith-Marie d'. "Biocapteur ampérométrique pour la détection des ions phosphate : étude approfondie de l'immobilisation du système bienzymatique PNP-XOD, performances et applications." Lyon 1, 1992. http://www.theses.fr/1992LYO10145.

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Ce travail presente l'etude d'un biocapteur bienzymatique specifique des ions phosphate. La purine nucleoside phosphorylase (pnp) et la xanthine oxydase (xod) sont co-immobilisees sur une membrane synthetique preactivee placee au contact d'une electrode amperometrique en platine capable de detecter l'eau oxygenee et l'acide urique generes enzymatiquement. L'influence sur les performances du biocapteur du rapport des activites enzymatiques dans la solution de couplage et des activites totales deposees a ete etudiee. Nous demontrons que l'optimisation de ces deux parametres permet d'ameliorer no

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33

Richter, Tanja. "Entwicklung alternativer Methoden zur Nukleotid-Analytik in der Bioprozessüberwachung." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=959651853.

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34

Donyai, Parastou. "Xanthine oxidase in oxidative stress : design and evaluation of novel inhibitors." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300381.

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35

Harris, Christopher Peter David. "Lipoprotein quality, anti-(xanthine oxidase) antibodies and coronary heart disease risk." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760669.

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36

Cultrone, Antonietta. "La xanthine dioxygénase α-kétoglutarate dépendante : une enzyme caractéristique des champignons". Paris 11, 2004. http://www.theses.fr/2004PA112069.

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Le sujet de cette thèse est le clonage du gène xanA et le caractérisation de la protéine XanA d'Aspergillus nidulans. XanA est une enzyme qui hydroxyle la xanthine en acide urique. Dans une souche sauvage la purine hydroxylase I (HxA) catalyse l'hydroxylation de l'hypoxanthine en xanthine et de la xanthine en acide urique. L'hypoxanthine peut aussi être hydroxylée par la purine hydroxylase II codée par le gène hxnS. Les purines hydroxylases I et II sont des enzymes associées à un cofacteur à molybdène, alors que XanA ne l'est pas. Nous avons cloné et séquencé le gène xanA. Il code une protéine

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37

Mokfi, Moloud [Verfasser]. "Xanthine-derived N-heterocyclic carbenes and their metal complexes / Moloud Mokfi." Wuppertal : Universitätsbibliothek Wuppertal, 2021. http://d-nb.info/1240266960/34.

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38

Sayin, Hasan McKee Michael L. "Quantum chemical studies and kinetics of gas reactions." Auburn, Ala, 2006. http://repo.lib.auburn.edu/2006%20Fall/Dissertations/SAYIN_HASAN_39.pdf.

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39

Jawed, Shahid. "The role of the redox enzyme xanthine oxido-reductase in rheumatoid arthritis." Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391624.

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40

Aburas, Omaro A. Emhmed. "Investigation of aldehyde oxidase and xanthine oxidoreductase in rainbow trout (Oncorhynchus mykiss)." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/23543/.

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Molybdo-flavoenzymes (MFEs), aldehyde oxidase (AOX) and xanthine oxidoreductase (XOR) are involved in the oxidation of N-heterocyclic compounds and aldehydes, many of which are environmental pollutants, drugs and vitamins. This biotransformation generally generates more polar compounds that are more easily excreted, thus MFEs have been classed as detoxication enzymes. To date there has been scant study of the properties, substrate and inhibitor specificities of MFEs in non-mammalian vertebrate organisms. This investigation focuses on MFEs in rainbow trout (Oncorhynchus mykiss) as it belongs to

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41

Dong, Liang. "Novel xanthine and oxanine DNA glycosylase activities in yeast and mammalian systems." Connect to this title online, 2008. http://etd.lib.clemson.edu/documents/1239895528/.

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42

Perino, Isabelle. "Café, thé, maté, guarana : drogues végétales à bases xanthiques." Paris 5, 1990. http://www.theses.fr/1990PA05P044.

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43

Liu, Shiu Cheong Patrick. "Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease." Thesis, University of Dundee, 2019. https://discovery.dundee.ac.uk/en/studentTheses/ee8678d8-e7c7-498c-b501-ff5522f32ae5.

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Chronic lung diseases are often complicated with pulmonary hypertension (PH). This can lead to disability and poor prognosis. Oxidative stress has been implicated in the development of PH and right ventricular hypertrophy (RVH).A possible new way to treat lung disease related pulmonary hypertension is allopurinol (a xanthine oxidase inhibitor) which decreases both uric acid and oxidative stress. We hypothesised that allopurinol could regress RVH in patients with pulmonary hypertension associated with chronic lung disease (PH-CLD).In a double-blind, randomised controlled clinical trial, 72 pati

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44

Choi, Eun-Young. "Studies on the reaction mechanism of the reductive half-reaction of Xanthine Oxidase /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu148819366523445.

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45

Abooali, Maryam. "Crucial involvement of xanthine oxidoreductase in the biological responses of myeloid hematopoietic cells." Thesis, University of Kent, 2015. https://kar.kent.ac.uk/49841/.

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Xanthine oxidoreductase (XOR) is one of the main purine catabolising enzymes which converts hypoxanthine into xanthine and further into uric acid. The enzyme has a homodimeric structure and contains two FeS centres, one FAD molecule and one molybdenum atom per monomer. Recent evidence clearly demonstrated that XOR activity is highly increased in human hematopoietic cells of myeloid lineage during their pathogen-induced and endogenously generated biological responses. The integrative signalling role and especially involvement of XOR in cross-talk of metabolic and signalling machinery of human l

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46

Hoare, Catherine Anne. "The localisation and activity of xanthine oxidoreductase in human endothelial and epithelial cells." Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268383.

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47

Tao, Li. "Expression and distribution of butyrophilin 1A1 and xanthine dehydrogenase-oxidase in lactating mammary gland." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3698.

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Thesis (M.S.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Dept. of Cell Biology and Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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48

Rajendra, N. S. "Exploring the therapeutic potential of xanthine oxidase inhibitor-AUopurinol, in stable coronary artery disease." Thesis, University of Dundee, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521663.

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49

Mbewe, Boniface. "Cloning, expression, purification and drug targeting of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT)." Doctoral thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/2696.

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Includes bibliographical references.<br>The research concerns sub-cloning the gene for HGXPRT from Plasmodium falciparum from a vector with a His-tag facility to one without, expression of the protein in E. coli, and purification. On an analytical scale (40 ml culture), a purification procedure was developed that involves extraction of contaminating proteins by anion exchange chromatography (HGXPRT does not bind under the conditions used), followed by Reactive Red 120 agarose affinity chromatography.

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50

Watanabe, Koji. "Pterin-6-aldehyde, an Inhibitor of Xanthine Oxidase, Has Superoxide Anion Radical Scavenging Activity." Kyoto University, 2000. http://hdl.handle.net/2433/151411.

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