Gotowe bibliografie tematyczne / Δ-Lactams

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Gotowa bibliografia na temat „Δ-Lactams”

Autor: Grafiati

Data publikacji: 25 stycznia 2025

Data aktualizacji: 31 lipca 2025

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Artykuły w czasopismach na temat "Δ-Lactams"

Coullon, Héloise, Aline Rifflet, Richard Wheeler, Claire Janoir, Ivo Gomperts Boneca та Thomas Candela. "N-Deacetylases required for muramic-δ-lactam production are involved in Clostridium difficile sporulation, germination, and heat resistance". Journal of Biological Chemistry 293, № 47 (2018): 18040–54. http://dx.doi.org/10.1074/jbc.ra118.004273.

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Spores are produced by many organisms as a survival mechanism activated in response to several environmental stresses. Bacterial spores are multilayered structures, one of which is a peptidoglycan layer called the cortex, containing muramic-δ-lactams that are synthesized by at least two bacterial enzymes, the muramoyl-l-alanine amidase CwlD and the N-deacetylase PdaA. This study focused on the spore cortex of Clostridium difficile, a Gram-positive, toxin-producing anaerobic bacterial pathogen that can colonize the human intestinal tract and is a leading cause of antibiotic-associated diarrhea.

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Glover, Stephen A., Adam A. Rosser, Avat (Arman) Taherpour, and Ben W. Greatrex. "Formation and HERON Reactivity of Cyclic N,N-Dialkoxyamides." Australian Journal of Chemistry 67, no. 3 (2014): 507. http://dx.doi.org/10.1071/ch13557.

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Cyclic N,N-dialkoxyamides have been made, for the first time, by hypervalent iodine oxidation of β- and γ-hydroxyhydroxamic esters 17, 19, and 21. The fused γ-lactam products, N-butoxy- and N-benzyloxybenzisoxazolones (22a and 22b), are stable while alicyclic γ-lactam and δ-lactam products, 24 and 25, although observable by NMR spectroscopy and ESI-MS are unstable at room temperature, undergoing HERON reactions. The γ-lactam 24 undergoes exclusive ring opening to give a butyl ester-functionalised alkoxynitrene 28. The δ-lactam 25, instead, undergoes a HERON ring contraction to give butyrolacto

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Wang, Xin, Jia Lei, Guofeng Li, et al. "Synthetic methods for compounds containing fluoro-lactam units." Organic & Biomolecular Chemistry 18, no. 48 (2020): 9762–74. http://dx.doi.org/10.1039/d0ob02168g.

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This review highlights recent progress in the construction of fluorinated lactams, including fluoro-β-lactams, fluoro-γ-lactams, and fluoro-δ-lactams, with an emphasis on the scopes, limitations and mechanisms of these different reactions.

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Boudreault, Nicolas, Richard G. Ball, Christopher Bayly, Michael A. Bernstein та Yves Leblanc. "Conformational analysis of δ-lactams". Tetrahedron 50, № 27 (1994): 7947–56. http://dx.doi.org/10.1016/s0040-4020(01)85279-0.

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Domingo, Luis R., та José A. Sáez. "Understanding the selectivity in the formation of δ-lactams vs. β-lactams in the Staudinger reactions of chloro-cyan-ketene with unsaturated imines. A DFT study". RSC Adv. 4, № 102 (2014): 58559–66. http://dx.doi.org/10.1039/c4ra10291f.

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Rossi-Ashton, James A., Richard J. K. Taylor, and William P. Unsworth. "Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation." Organic & Biomolecular Chemistry 15, no. 36 (2017): 7527–32. http://dx.doi.org/10.1039/c7ob02039b.

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Diaba, Faïza, Alexandra G. Sandor та María del Carmen Morán. "Microwave-Assisted Atom Transfer Radical Cyclization in the Synthesis of 3,3-Dichloro-γ- and δ-Lactams from N-Alkenyl-Tethered Trichloroacetamides Catalyzed by RuCl2(PPh3)3 and Their Cytotoxic Evaluation". Molecules 29, № 9 (2024): 2035. http://dx.doi.org/10.3390/molecules29092035.

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An expeditious synthesis of γ- and δ-lactams from tethered alkenyl trichloroacetamides in the presence of 5% of RuCl2(PPh3)3 is reported. In this investigation we have demonstrated that microwave activation significantly enhances reaction rates, leading to the formation of the corresponding lactams in yields ranging from good to excellent. Thus, we have been able to prepare a wide range of lactams, including indole and morphan bicyclic scaffolds, where the corresponding reactions were completely diastereoselective. This process was successfully extended to α,α-dichloroamides without affecting

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Albrecht, Anna, Łukasz Albrecht та Tomasz Janecki. "Recent Advances in the Synthesis of α-Alkylidene-Substituted δ-Lactones, γ-Lactams and δ-Lactams". European Journal of Organic Chemistry 2011, № 15 (2011): 2747–66. http://dx.doi.org/10.1002/ejoc.201001486.

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Fleet, George W. J., Nigel G. Ramsden, Raymond A. Dwek та ін. "δ-Lactams: synthesis fromD-glucose, and preliminiary evaluation as a fucosidase inhibitor, ofL-fuconic-δ-lactam". J. Chem. Soc., Chem. Commun., № 7 (1988): 483–85. http://dx.doi.org/10.1039/c39880000483.

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Gan, Miaomiao, Lan Jiang та Zhengning Li. "Diastereoselective Synthesis of γ-Lactams and δ-Lactams via a Conjugate Addition-Initiated Tandem Reaction". Synlett 30, № 12 (2019): 1447–51. http://dx.doi.org/10.1055/s-0037-1611552.

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β-Alkoxycarbonyl-γ-lactams and γ-alkoxycarbonyl-δ-lactams were synthesized via a conjugate alkylation/Mannich reaction/lactamization tandem reaction of unsaturated dicarboxylates with diethyl zinc and aldimines. The high yield, the ready availability of the reagents, and especially the high diastereoselectivity are promising characteristics of the approach that allows access to functionalized lactams.

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Rozprawy doktorskie na temat "Δ-Lactams"

Dad, Mohammad M. (Mohammad Mehdj). "Aminoketene. Cycloaddition of Ketenes and Imines to Yield β- or δ- Lactams". Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc332534/.

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The purpose of this investigation was to provide a systematic study of the cycloaddition pf (N-alkyl-N-phenylamino)- methoxy-and dichloroketenes to various imines and to investigate the stereochemistry of these cycloadditions.

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Coullon, Héloïse. "Analyse fonctionnelle des N-déacétylases de Clostridium difficile." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS503.

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Clostridium difficile est une bactérie anaérobie sporulante responsable de 15 à 25% des diarrhées post-antibiotiques. Les N-déacétylases sont largement distribuées parmi les bactéries à Gram positif et elles sont impliquées dans différentes fonctions de surface. L'analyse du génome de C. difficile montre que 13 gènes codent pour des N-déacétylases potentielles, et nous avons caractérisé l’ensemble de ces N-déacétylases.Le peptidoglycane de la cellule végétative de C. difficile est N-déacétylé sur 93% des glucosamines, et cette modification participe à la résistance de la bactérie au lysozyme,

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Champetter, Philippe. "Utilisation des propriétés des N-alkoxyamides pour la synthèse de γ- et δ- lactames hautement fonctionnalisés par des processus domino". Thesis, Normandie, 2017. http://www.theses.fr/2017NORMLH18.

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Les hétérocycles azotés occupent une place importante en chimie organique et médicinale et, à ce titre, constituent des cibles de choix pour le développement de réactions toujours plus efficaces et faciles d’emploi. Les travaux antérieurs, réalisés au laboratoire URCOM sur l’accès aux γ-lactames, ont servi de base pour développer une méthodologie impliquant des conditions douces qui ont mis en évidence les propriétés spécifiques des N-alkoxy amides pour accéder aux γ- et δ-lactames hautement fonctionnalisés de manière hautement diastéréosélective selon un processus domino. Cette méthodologie a

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Le, Goff Ronan. "Utilisation de réactions tandem et domino pour l'accès rapide à des hétérocycles azotés." Thesis, Le Havre, 2015. http://www.theses.fr/2015LEHA0014/document.

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La présence importante des hétérocycles azotés en chimie organique et médicinale explique le grand intérêt et les très nombreuses recherches dont ils font l’objet. Parmi tous ces motifs, les pyrrolidines ainsi que les γ- et δ-lactames bicycliques ont tout particulièrement focalisé notre attention. En se basant sur des résultats antérieurs obtenus au laboratoire nous avons mis au point deux nouvelles voies d’accès rapides et innovantes pour accéder diastéréosélectivement à ces motifs. D’une part une réaction tandem aza-MIRC (Michael Induced Ring Closure) a permis de former des pyrrolidines poly

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Genty, Axelle. "Synthèse stéréοsélective d’hétérοcycles azοtés par réactiοns mοnοtοpes dοminο". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMLH30.

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Les hétérocycles azotés sont particulièrement présents en chimie médicinale et pharmaceutique. Les δ-lactames, en particulier, connaissent un essor croissant en raison de leur fort intérêt biologique et de leur utilisation en tant qu'intermédiaires réactionnels pour la synthèse de molécules d'intérêt. L’étude croissante de ces composés conduit à une recherche de nouvelles voies de synthèse pour accéder à ces motifs polyfonctionnalisés. Les réactions monotopes se distinguent comme une stratégie privilégiée, permettant, en une seule étape, la formation de multiples liaisons et centres stéréogène

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Fernandes, Fábio de Souza. "Aplicação da reação de mannich na síntese de derivados da pirazinamida e no estudo da estereoseletividade de δ- lactamas". Universidade Federal de Juiz de Fora, 2016. https://repositorio.ufjf.br/jspui/handle/ufjf/1509.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-05-13T18:09:13Z No. of bitstreams: 1 fabiodesouzafernandes.pdf: 24065820 bytes, checksum: da2a7ed64d78294c49d6e226495eda40 (MD5) Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-06-27T21:20:25Z (GMT) No. of bitstreams: 1 fabiodesouzafernandes.pdf: 24065820 bytes, checksum: da2a7ed64d78294c49d6e226495eda40 (MD5) Made available in DSpace on 2016-06-27T21:20:25Z (GMT). No. of bitstreams: 1 fabiodesouzafernandes.pdf: 24065820 bytes, checksum: da2a7ed64d78294c49d6e226495eda40 (MD5) Previ

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Lin, Huey-Jen, та 林慧貞. "A Facile Synthesis of N—Substituted Monocyclic γ— and δ— Lactams From Corresponding Lactones". Thesis, 1996. http://ndltd.ncl.edu.tw/handle/70086270401124162569.

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Huang, Chang-Gin, та 黃章琴. "An Efficient Synthesis of γ-Substituted α,β-Unsaturated δ-Lactams. Formal Synthesis of (±)-Protoemetinol". Thesis, 2002. http://ndltd.ncl.edu.tw/handle/73440334973666049886.

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Tung, Po-Ting, та 董柏廷. "Lewis acid-Promoted Cyclization Reaction of Six-Membered Ring Enynamides : Synthesis of Bridged- and Fused-Bicyclic δ-Lactams". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/25qqa3.

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碩士 國立臺灣師範大學 化學系 105 The thesis contains two topics. The first part is the synthesis of bridged bicyclic δ-lactams via gold(I)-catalyzed intramolecular cycloisomerization/ox -idation of N-tosyl-4-ynamidomethylcyclohexenes. The second part is the synthesis of hexahydroisoquinolinone derivatives via BF3.OEt2-promoted intramolecular cyclization of alkyl- or aryl-substituted O-silyl-protected 2-((ethynylamino)methyl)cyclohex-2-enols. N-Tosyl-4-ynamidomethylcyclohexenes underwent cycloisomerization in the presence of a catalytic amount of a gold(I) complex delivering 4-azatricyclo[4.2.2.

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HsieH, Tai-ran, та 謝泰然. "Synthetic studies toward 3,4,5-trisubstituted-piperidine and cis-4-substituted-5-amino-δ-lactam". Thesis, 2004. http://ndltd.ncl.edu.tw/handle/86407437083433455480.

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Części książek na temat "Δ-Lactams"

Albrecht, Łukasz, Anna Albrecht, and Tomasz Janecki. "α-Alkylidene-γ- and δ-Lactones and Lactams." In Natural Lactones and Lactams. Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527666911.ch4.

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Hone, Neal D., Siri Ram Chhabra, and Barrie W. Bycroft. "In situ synthesis of δ-lactams in continuous flow SPPS." In Peptides 1992. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_121.

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Faska, Nadia, Soukayna Maitouf, and Brahim Orayech. "Molecular Interaction of Lactams With Mild Steel in Hydrochloric Acid Environment." In Advances in Chemical and Materials Engineering. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-7505-1.ch007.

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The inhibition effect of some lactams (Pyrrolidin‐2‐one, δ‐valerolactam, and ε‐caprolactam) on the corrosion behaviour of mild steel in 1M Hydrochloric acid solution was studied by weight loss and electrochemical techniques. The results demonstrated that both δ‐valerolactam, and ε‐caprolactam significantly inhibit corrosion. Specifically, δ‐valerolactam achieved an inhibition efficiency of 85.2%, while ε‐caprolactam exhibited a higher inhibition efficiency of 91.5%. The thermodynamic parameters governing the adsorption process such as adsorption heat, adsorption entropy, and adsorption free en

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Yanagisawa, A. "Favorskii-Type Ring Contraction of α-Chloro-δ-lactams." In Compounds of Groups 13 and 2 (Al, Ga, In, Tl, Be...Ba). Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-007-00730.

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Tidwell, T. T. "β- and δ-Lactams by Cycloaddition of Bromoketenes with Imines." In Three Carbon-Heteroatom Bonds: Thio-, Seleno-, and Tellurocarboxylic Acids and Derivatives; Imidic Acids and Derivatives; Ortho Acid Derivatives. Georg Thieme Verlag KG, 2006. http://dx.doi.org/10.1055/sos-sd-023-00131.

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Tidwell, T. T. "δ-Lactams by [4+2] Cycloaddition with Chiral 2-Vinyl-4,5-dihydrothiazoles." In Three Carbon-Heteroatom Bonds: Thio-, Seleno-, and Tellurocarboxylic Acids and Derivatives; Imidic Acids and Derivatives; Ortho Acid Derivatives. Georg Thieme Verlag KG, 2006. http://dx.doi.org/10.1055/sos-sd-023-00468.

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Tidwell, T. T. "β- and δ-Lactams by [2+2]- and [4+2]-Cycloaddition Reactions of Chloroketenes with Vinylic Imines." In Three Carbon-Heteroatom Bonds: Thio-, Seleno-, and Tellurocarboxylic Acids and Derivatives; Imidic Acids and Derivatives; Ortho Acid Derivatives. Georg Thieme Verlag KG, 2006. http://dx.doi.org/10.1055/sos-sd-023-00110.

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"Chiral Auxiliaries." In Chirality from Dynamic Kinetic Resolution. The Royal Society of Chemistry, 2011. http://dx.doi.org/10.1039/bk9781849731973-00001.

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This chapter deals with the use of chiral auxiliaries for the asymmetric induction through a DKR process. In the last fifteen years, a wide number of various chiral auxiliaries have been employed in DKR processes occurring in different types of reactions, such as substitution reactions involving configurationally-labile alkyl halides or configurationally-labile anions, esterification and transesterification reactions, cyclocondensation reactions, reductions, cycloaddition reactions, and miscellaneous reactions. One of the most studied reactions has been the nucleophilic substitution on configu

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Taber, Douglass F. "The Dixon Synthesis of (-)-Nakadomarin A." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0087.

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(-)-Nakadomarin A 4, isolated from the sponge Amphimedon sp. off the coast of Okinawa, shows interesting antifungal and antibacterial activity. The key step in the total synthesis of 4 reported (J. Am. Chem. Soc. 2009, 131, 16632) by Darren J. Dixon of the University of Oxford was the diastereoselective addition of the enantiomerically pure ester 1 to the prochiral nitroalkene 2. The assembly of 2 began with the linchpin ketophosphonate 5. Alkylation of the dianion of 5 with allyl bromide followed by direct condensation of the resulting monoanion with the diacetate 6 gave 7. On exposure to aqu

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Taber, Douglass F. "The Dixon Synthesis of Manzamine A." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0100.

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The pentacyclic alkaloid manzamine A 4, isolated from a sponge collected in the Okinawa Sea, displays a range of antibacterial, anticancer, and antimalarial activity. The preparation of 4 reported (J. Am. Chem. Soc. 2012, 134, 17482) by Darren J. Dixon of the University of Oxford showcases the versatility of the nitro group in organic synthesis. The nitro alkene 2 was prepared from the commercial bromide 5. Displacement with acetate followed by Swern oxidation led to the aldehyde 6, which was condensed with nitromethane to give 2. Lactam 1 was an intermediate in Professor Dixon’s synthesis (Or

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