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1

Mukherjee, Joydeep, Gautam Guha, and Shankar Prasad Saha. "Two-year prospective study on various anti-epileptic drugs in drug-resistant epilepsy patients and parameters affecting seizure-freedom in Eastern Indian subcontinent." Asian Journal of Medical Sciences 10, no. 3 (2019): 27–36. http://dx.doi.org/10.3126/ajms.v10i3.23481.

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Background: Epilepsy is a disease of suffering. Drug-resistant epilepsy (DRE) takes a heavy toll on patients, family and society in the form of prolonged treatment, expenditure, unemployment and disability. Successful treatment depends on appropriate antiepileptic drug (AED) use in appropriate dosage, which varies in different parts of the world.
 Aims and Objectives: To find out AED efficacy in Indian subcontinent and factors affecting seizure freedom.
 Materials and Methods: We explored many characteristics of DRE patients, compared in between seizure-free and seizure-persisting pa
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2

Davis, B. J. "AED withdrawal." Neurology 48, no. 4 (1997): 1137. http://dx.doi.org/10.1212/wnl.48.4.1137-a.

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3

Manek, P. "AED value." British Dental Journal 210, no. 11 (2011): 501. http://dx.doi.org/10.1038/sj.bdj.2011.432.

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4

Karlsson, Lena, Carolina Malta Hansen, Mads Wissenberg, et al. "Data concerning AED registration in the Danish AED Network, and cardiac arrest-related characteristics of OHCAs, including AED coverage and AED accessibility." Data in Brief 24 (June 2019): 103960. http://dx.doi.org/10.1016/j.dib.2019.103960.

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5

Derambure, Philippe, Rob McMurray, Rui Sousa, and Martin Holtkamp. "ESLICARBAZEPINE ACETATE AS ADD-ON TO DIFFERENT AED MONOTHERAPIES." Journal of Neurology, Neurosurgery & Psychiatry 87, no. 12 (2016): e1.228-e1. http://dx.doi.org/10.1136/jnnp-2016-315106.89.

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6

Naritoku, Dean K., Joseph F. Hulihan, Lesley Kraut Schwarzman, Marc Kamin, and William H. Olson. "Effect of Cotherapy Reduction on Tolerability of Epilepsy Add-On Therapy: A Randomized Controlled Trial." Annals of Pharmacotherapy 39, no. 3 (2005): 418–23. http://dx.doi.org/10.1345/aph.1e403.

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BACKGROUND: Adverse effects are the most common cause for failure of an antiepileptic drug (AED), especially when an AED is added to existing therapy. With the increased drug load, it may not be possible to titrate the newly added AED to effective doses. Reducing the dosage of AED cotherapy as the new drug is introduced may improve tolerability. OBJECTIVE: To evaluate reduction of AED cotherapy as a strategy to improve tolerability and patient retention when a new AED is added to existing therapy. METHODS: In a 20-week, randomized, open-label study, topiramate was initiated as add-on therapy i
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7

Mistry, N. "Register your AED." British Dental Journal 231, no. 9 (2021): 532–33. http://dx.doi.org/10.1038/s41415-021-3626-3.

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8

Volk, Holger, Marios Charalabous, and David Brodbelt. "Canine AED efficacy." Companion Animal 19, no. 12 (2014): 631. http://dx.doi.org/10.12968/coan.2014.19.12.631.

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9

Santos, Nelson, Pedro Caldeira, Nuno Gaibino, et al. "P123 Ocean Medical's AED Program – Outcomes of a Portuguese AED Program." Resuscitation 175 (June 2022): S82. http://dx.doi.org/10.1016/s0300-9572(22)00533-0.

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10

Fernandez, Clint Jean Louis, Diego Reyero Diez, Carlos Beaumont Caminos, Javier Fernandez Eito, Lluna Martinez, and Nikole Velilla Mendoza. "THE AED TRAINER BOX: Making AED training easier for the community." Resuscitation 130 (September 2018): e67. http://dx.doi.org/10.1016/j.resuscitation.2018.07.133.

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11

Stokes, Nathan Allen, Andrea Scapigliati, Antoine R. Trammell, and David C. Parish. "The Effect of the AED and AED Programs on Survival of Individuals, Groups and Populations." Prehospital and Disaster Medicine 27, no. 5 (2012): 419–24. http://dx.doi.org/10.1017/s1049023x12001197.

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AbstractObjectiveThe automated external defibrillator (AED) is a tool that contributes to survival with mixed outcomes. This review assesses the effectiveness of the AED, consistencies and variations among studies, and how varying outcomes can be resolved.MethodsA worksheet for the International Liaison Committee on Resuscitation (ILCOR) 2010 science review focused on hospital survival in AED programs was the foundation of the articles reviewed. Articles identified in the search covering a broader range of topics were added. All articles were read by at least two authors; consensus discussions
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12

van der Meer, Pim, Linda Dirven, Marta Fiocco, et al. "NCOG-15. THE EFFECTIVENESS OF ANTIEPILEPTIC DRUG DUOTHERAPIES IN GLIOMA PATIENTS: A MULTICENTER OBSERVATIONAL COHORT STUDY." Neuro-Oncology 23, Supplement_6 (2021): vi155. http://dx.doi.org/10.1093/neuonc/noab196.606.

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Abstract BACKGROUND Uncontrolled seizures on antiepileptic drug (AED) monotherapy are common in glioma patients and about a third of patients need an add-on AED. The aim of this study was to determine whether levetiracetam combined with valproic acid (LEV+VPA), a commonly prescribed duotherapy, was more effective than other duotherapy combinations, which included either LEV or VPA, in glioma patients. METHODS In this multicenter observational cohort study, data of patients with a diffuse grade 2-4 glioma and having uncontrolled seizures on their first-line monotherapy LEV or VPA, was retrospec
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13

van der Meer, P. B., L. Dirven, M. Fiocco, et al. "OS10.8.A The effectiveness of antiepileptic drug duotherapies in glioma patients: a multicenter observational cohort study." Neuro-Oncology 23, Supplement_2 (2021): ii14. http://dx.doi.org/10.1093/neuonc/noab180.046.

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Abstract BACKGROUND About 30% of glioma patients need an add-on antiepileptic drug (AED) due to uncontrolled seizures on AED monotherapy. This study aimed to determine whether levetiracetam combined with valproic acid (LEV+VPA), a commonly prescribed duotherapy, is more effective than other duotherapy combinations including either LEV or VPA in glioma patients. MATERIAL AND METHODS In this multicenter retrospective observational cohort study, treatment failure (i.e. replacement by or addition of a new AED, or withdrawal of an AED) for any reason was the primary outcome. Secondary outcomes incl
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14

Millichap, J. Gordon. "AED Withdrawal: Risk Factors." Pediatric Neurology Briefs 8, no. 6 (1994): 41. http://dx.doi.org/10.15844/pedneurbriefs-8-6-1.

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Millichap, J. Gordon. "AED/Oral Contraceptive Interactions." Pediatric Neurology Briefs 10, no. 7 (1996): 54. http://dx.doi.org/10.15844/pedneurbriefs-10-7-9.

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16

Balmer, M. C., and L. P. Longman. "AED training for dentists." British Dental Journal 201, no. 8 (2006): 488. http://dx.doi.org/10.1038/sj.bdj.4814163.

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17

Helmstaedter, C. "Epilepsy, AED, and cognition." Epilepsy & Behavior 28, no. 2 (2013): 309. http://dx.doi.org/10.1016/j.yebeh.2012.04.027.

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18

Reinhardt, L., J. Bahr, O. Schmid, D. Kettler, and M. Roessler. "Das Göttinger AED-Modell." Notfall + Rettungsmedizin 13, no. 3 (2010): 219–26. http://dx.doi.org/10.1007/s10049-010-1311-1.

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19

French, Jacqueline A. "Response to First AED." Epilepsy Currents 2, no. 3 (2002): 72–73. http://dx.doi.org/10.1046/j.1535-7597.2002.t01-1-00026.x.

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20

Greener, Mark. "Statins, psoriasis, AED abuse." Independent Nurse 2013, no. 20 (2013): 17. http://dx.doi.org/10.12968/indn.2013.20.17.

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21

French, Jacqueline A. "Response to First AED." Epilepsy Currents 2, no. 3 (2002): 72–73. http://dx.doi.org/10.1111/j.1535-7597.2002.t01-1-00026.x.

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Effectiveness of First Antiepileptic Drug Kwan P, Brodie MJ Epilepsia 2001;42:1255–1260 Purpose To investigate the interaction among efficacy, tolerability, and overall effectiveness of the first antiepileptic drug (AED) in patients with newly diagnosed epilepsy. Methods The 470 patients were diagnosed, treated and followed up from January 1984 at a single center. Outcome was classified as seizure freedom for at least the last year or failure of initial treatment because of inadequate seizure control, adverse events, or for other reasons. Results Overall, 47% of patients became seizure free wi
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22

Millichap, J. Gordon. "Mechanisms of AED action." Pediatric Neurology 7, no. 1 (1991): 72. http://dx.doi.org/10.1016/0887-8994(91)90114-z.

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23

Talwar, Dinesh. "Mechanisms of AED action." Pediatric Neurology 7, no. 1 (1991): 72. http://dx.doi.org/10.1016/0887-8994(91)90115-2.

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24

Suzuki, H. "Maintenance of AED in the Hospital(AED, The Preferable Management and Future)." Iryou kikigaku (The Japanese journal of medical instrumentation) 78, no. 6 (2008): 399–404. http://dx.doi.org/10.4286/jjmi.78.399.

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25

Baldi, Enrico, Niccolò B. Grieco, Giuseppe Ristagno, et al. "The Automated External Defibrillator: Heterogeneity of Legislation, Mapping and Use across Europe. New Insights from the ENSURE Study." Journal of Clinical Medicine 10, no. 21 (2021): 5018. http://dx.doi.org/10.3390/jcm10215018.

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Introduction: The rapid use of an automated external defibrillator (AED) is crucial for increased survival after an out-of-hospital cardiac arrest (OHCA). Many factors could play a role in limiting the chance of an AED use. We aimed to verify the situation regarding AED legislation, the AED mapping system and first responders (FRs) equipped with an AED across European countries. Methods: We performed a survey across Europe entitled “European Study about AED Use by Lay Rescuers” (ENSURE), asking the national coordinators of the European Registry of Cardiac Arrest (EuReCa) program to complete it
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26

van der Meer, P. B., L. Dirven, M. Fiocco, et al. "P09.06.B The effectiveness of antiepileptic drug tripletherapy in refractory epileptic glioma patients: a multicenter observational cohort study." Neuro-Oncology 24, Supplement_2 (2022): ii47—ii48. http://dx.doi.org/10.1093/neuonc/noac174.164.

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Abstract Background About 10% of the glioma patients need antiepileptic drug (AED) tripletherapy due to refractory epilepsy. This study aimed to determine whether levetiracetam combined with valproic acid and clobazam (LEV+VPA+CLB), a commonly prescribed tripletherapy, has favourable effectiveness compared to other tripletherapy combinations in glioma patients. Material and Methods In this multicenter retrospective observational cohort study, the primary outcome was the cumulative incidence of treatment failure for any reason, from initiation of AED tripletherapy. Secondary outcomes included c
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27

Raju Sagiraju, Hari K., Chen-Pin Wang, Megan E. Amuan, Anne C. Van Cott, Hamada H. Altalib, and Mary Jo V. Pugh. "Antiepileptic drugs and suicide-related behavior." Neurology: Clinical Practice 8, no. 4 (2018): 331–39. http://dx.doi.org/10.1212/cpj.0000000000000489.

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BackgroundWe sought to compare trends of suicide-related behavior (SRB) before and after initiation of antiepileptic drug (AED) therapy among AED users (with and without epilepsy) to that of individuals without AED use controlling for sociodemographic characteristics and mental health comorbidity.MethodsWe used national Veterans Health Administration (VHA) data for post-9/11 veterans who received VHA care (2013–2014) without prior AED use. We conducted generalized estimation equation (GEE) analyses, stratified by epilepsy status and type of AED received, to assess the trend of SRB prevalence t
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28

Pennell, Page B. "Too Complicated or So Simple: AED Type and AED Dose Matter for Pregnancy." Epilepsy Currents 12, no. 2 (2012): 63–65. http://dx.doi.org/10.5698/1535-7511-12.2.63.

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29

Ahmed, Mohsen, Afaaq Ahmed, Ronak Trivedi, et al. "Do Anti-Epileptic Drugs Increase High Risk Comorbidity Amongst Patients With Neuro-Autoimmune Disease?" Neurology 99, no. 23 Supplement 2 (2022): S16.1—S16. http://dx.doi.org/10.1212/01.wnl.0000903152.06982.75.

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ObjectiveTo investigate the effects of anti-epileptic drugs (AED) on the overall burden of disease in patients with neuro-autoimmune disease (NAD).BackgroundAEDs have shown to provide benefits against neurological damage in patients with various neurological illnesses. However, the extent of AEDs role in neuroprotection and the prevention of additional comorbidity in patients with NAD has not been completely characterized.Design/MethodsA retrospective analysis on 34464 patients hospitalized at a tertiary care center in a major metropolitan area was conducted. 3997 patients were on AED medicati
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30

Gao, Feng, Siyi Lu, Shunyi Liao, et al. "AED Inequity among Social Groups in Guangzhou." ISPRS International Journal of Geo-Information 13, no. 4 (2024): 140. http://dx.doi.org/10.3390/ijgi13040140.

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Automated external defibrillators (AEDs) are regarded as the most important public facility after fire extinguishers due to their importance to out-of-hospital cardiac arrest (OHCA) victims. Previous studies focused on the location optimization of the AED, with little attention to inequity among different social groups. To comprehensively investigate the spatial heterogeneity of the AED inequity, we first collected AED data from a WeChat applet. Then, we used the geographically weighted regression (GWR) model to quantify the inequity level and identify the socio-economic status group that face
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31

De Oliveira, Julia Andrade, Iuri Amorim De Santana, Inacelli Queiroz de Souza Caires, et al. "Prophylactic anticonvulsants in patients (pts) with primary brain tumor (PBT): Have we really agreed to a consensus?" Journal of Clinical Oncology 31, no. 15_suppl (2013): 2060. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.2060.

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2060 Background: Routine prophylactic antiepileptic drugs (AED) use to prevent seizures in PBT seizure-naïve pts is not supported by current guidelines. However, the best management of prophylactic AED started in the perioperative setting is still unclear. Additionally, AED can have serious side effects, might have a negative impact on cognition and may present significant drug interactions. Little is known about actual current practice patterns regarding prophylactic AED in PBT. In this report we investigated prophylactic AED use in a tertiary care institution. Methods: We reviewed medical fi
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Millichap, J. Gordon. "AED-Associated Major Congenital Abnormalities." Pediatric Neurology Briefs 13, no. 11 (1999): 87. http://dx.doi.org/10.15844/pedneurbriefs-13-11-10.

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&NA;. "AED use rises in Denmark." Inpharma Weekly &NA;, no. 1550 (2006): 4. http://dx.doi.org/10.2165/00128413-200615500-00009.

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Sallis, Robert E., and Robert J. Dimeff. "When AED Leads Don't Stick." Physician and Sportsmedicine 30, no. 11 (2002): 10–14. http://dx.doi.org/10.3810/psm.2002.11.537.

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35

Lee, HeeTack, YouSik Hong, and SangSuk Lee. "AED System using Fuzzy Rules." Journal of the Institute of Webcasting, Internet and Telecommunication 13, no. 4 (2013): 215–20. http://dx.doi.org/10.7236/jiibc.2013.13.4.215.

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Baldi, Enrico, and Simone Savastano. "AED use before EMS arrival." European Heart Journal 39, no. 19 (2018): 1664. http://dx.doi.org/10.1093/eurheartj/ehy196.

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Sun, Christopher L. F., Lena Karlsson, Christian Torp-Pedersen, Laurie J. Morrison, Fredrik Folke, and Timothy C. Y. Chan. "Spatiotemporal AED optimization is generalizable." Resuscitation 131 (October 2018): 101–7. http://dx.doi.org/10.1016/j.resuscitation.2018.08.012.

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Salerno, Jessica, Connor Willson, Leonard Weiss, and David Salcido. "Myth of the stolen AED." Resuscitation 140 (July 2019): 1. http://dx.doi.org/10.1016/j.resuscitation.2019.04.036.

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Novikava, S., S. Gancharova, and P. Buka. "Mathematics Constructions in Aed Theory." IFAC Proceedings Volumes 31, no. 20 (1998): 977–82. http://dx.doi.org/10.1016/s1474-6670(17)41925-2.

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Pressler, Ronit. "S53 AED development in neonates." Clinical Neurophysiology 128, no. 9 (2017): e196. http://dx.doi.org/10.1016/j.clinph.2017.07.064.

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Trappe, H. J. "Einsatz automatisierter externer Defibrillatoren (AED)." Der Kardiologe 6, no. 1 (2012): 28–39. http://dx.doi.org/10.1007/s12181-011-0385-4.

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Penovich, Patricia E. "AED Effects on Bone Density." Epilepsy Currents 2, no. 5 (2002): 161–63. http://dx.doi.org/10.1046/j.1535-7597.2002.00060.x.

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Schönegg, M., and A. Bolz. "VOM DEFIBRILLATOR ZUM AED/PAD." Biomedizinische Technik/Biomedical Engineering 45, s1 (2000): 294–95. http://dx.doi.org/10.1515/bmte.2000.45.s1.294.

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&NA;. "AED for the Entire Hospital." Gastroenterology Nursing 22, no. 1 (1999): 31. http://dx.doi.org/10.1097/00001610-199901000-00012.

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Janigro, Damir, Sanjay Awasthi, Yogesh C. Awasthi, et al. "RLIP76 in AED drug resistance." Epilepsia 48, no. 6 (2007): 1218–19. http://dx.doi.org/10.1111/j.1528-1167.2007.01155_4.x.

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Penovich, Patricia E. "Aed Effects on Bone Density." Epilepsy Currents 2, no. 5 (2002): 161. http://dx.doi.org/10.1111/j.1535-7597.2002.00060.x.

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Antiepileptic Drug–induced Bone Loss in Young Male Patients with Seizures Andress DL, Ozuna J, Tirschwell D, Grande L, Johnson M, Jacobson AF, Spain W. Arch Neurol 2002;59:781–786 Background Long-term antiepileptic drug (AED) therapy is a known risk factor for bone loss and fractures. Vitamin D deficiency is frequently cited as a cause for bone loss in patients who have seizures. Objective To determine whether men who have seizures, but who are otherwise healthy, have substantial bone loss in the hip while taking AEDs. PATIENTS AND METHODS: We prospectively examined femoral neck bone mineral d
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Valk, Mark. "De AED het ziekenhuis uit!" Huisarts en wetenschap 54, no. 3 (2011): 118. http://dx.doi.org/10.1007/s12445-011-0057-4.

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Smith, Christopher M., Frances Griffiths, Rachael T. Fothergill, Ivo Vlaev, and Gavin D. Perkins. "Identifying and overcoming barriers to automated external defibrillator use by GoodSAM volunteer first responders in out-of-hospital cardiac arrest using the Theoretical Domains Framework and Behaviour Change Wheel: a qualitative study." BMJ Open 10, no. 3 (2020): e034908. http://dx.doi.org/10.1136/bmjopen-2019-034908.

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ObjectivesGoodSAM is a mobile phone app that integrates with UK ambulance services. During a 999 call, if a call handler diagnoses cardiac arrest, nearby volunteer first responders registered with the app are alerted. They can give cardiopulmonary resuscitation (CPR) and/or use a public access automated external defibrillator (AED). We aimed to identify means of increasing AED use by GoodSAM first responders.MethodsWe conducted semistructured telephone interviews, using the Theoretical Domains Framework to identify and classify barriers to AED use. We analysed findings using the Capability, Op
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Faropoulos, Konstantinos, Demosthenes Makris, and George Fotakopoulos. "The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury." Future Science OA 6, no. 10 (2020): FSO622. http://dx.doi.org/10.2144/fsoa-2020-0080.

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Aim: The value of anti-epileptic therapy in the prophylaxis of post-traumatic seizures. Patients & methods: All patients received a standard anti-epileptic drug (AED) and were divided into two groups: Group A -with early AED and Group B -with late AED. Results: Patients (871/1062) met the inclusion criteria. Multivariate analysis demonstrated that computer tomography findings, headache and prior history of brain head injury were independent risk factors of seizures. Only late post-traumatic seizures (LPTS) was significantly associated with AED (p < 0.05). Conclusion: Early treatment wit
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Andrews, Jessica, Christian Vaillancourt, Jan Jensen, et al. "Factors influencing the intentions of nurses and respiratory therapists to use automated external defibrillators during in-hospital cardiac arrest: a qualitative interview study." CJEM 20, no. 1 (2016): 68–79. http://dx.doi.org/10.1017/cem.2016.403.

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AbstractObjectivesNurses and respiratory therapists are seldom allowed to use automated external defibrillators (AED) during in-hospital cardiac arrest. This can result in significant time delays before defibrillation occurs and lower survival for cardiac arrest victims. We sought to identify barriers and facilitators to AED use by nurses and respiratory therapists.MethodsWe conducted semi-structured qualitative interviews with a purposeful sample of nurses and respiratory therapists. We developed the interview guide based on the constructs of the theory of planned behaviour, which elicits sal
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