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1

Chang, Patrick H., e Michael B. Steinberg. "ALCOHOL WITHDRAWAL". Medical Clinics of North America 85, n.º 5 (setembro de 2001): 1191–212. http://dx.doi.org/10.1016/s0025-7125(05)70372-2.

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2

Learoyd, B. M., John Spencer e Aidan Foy. "Alcohol withdrawal". Medical Journal of Australia 145, n.º 8 (outubro de 1986): 426. http://dx.doi.org/10.5694/j.1326-5377.1986.tb112408.x.

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3

Grieger, Thomas A., Deborah L. Warden e Cynthia Shappell. "Alcohol withdrawal". Medical Update for Psychiatrists 1, n.º 4 (julho de 1996): 139–43. http://dx.doi.org/10.1016/s1082-7579(96)80023-9.

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4

Bentley, Ava. "Alcohol Withdrawal". PACEsetterS 8, n.º 2 (abril de 2011): 19–21. http://dx.doi.org/10.1097/01.jbi.0000399627.96843.2f.

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5

Manasco, Anton, Shannon Chang, Joseph Larriviere, L. Lee Hamm e Marcia Glass. "Alcohol Withdrawal". Southern Medical Journal 105, n.º 11 (novembro de 2012): 607–12. http://dx.doi.org/10.1097/smj.0b013e31826efb2d.

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6

Sarangi, Ashish. "Alcohol withdrawal". Southwest Respiratory and Critical Care Chronicles 8, n.º 35 (23 de julho de 2020): 55–60. http://dx.doi.org/10.12746/swrccc.v8i35.717.

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Objective: This case review discusses the current recommended protocol for the diagnosis and treatment of delirium tremens using a review of a patient managed both in an inpatient psychiatry unit and in an intensive care unit. This review and case study are intended to help guide patient care with co-morbid conditions confounding diagnosis and in facilities lacking sophisticated monitoring equipment. Data Sources: PubMed was searched using keywords and phrases, including delirium tremens, alcohol withdrawal, chronic alcoholism, CIWA, alcohol effect on CNS, treatment of delirium tremens, and treatment of alcohol withdrawal. Study Selection: The case discussed provided the basis for this report based on its complexity due to comorbid conditions and the initial subacute presentation. Data Extraction: Data were gathered from charting notes written concurrently with patient management. Vital signs and laboratory values were regularly measured, and healthcare faculty documented each clinical encounter with findings and updates to treatment. Results: Delirium tremens was identified before progression to seizures and severe autonomic instability. Appropriate treatment and transfer to an intensive care unit were secured once a significant index of suspicion was reached. Conclusions: Close and frequent patient evaluation despite the lack of continuous monitoring technology allowed detection of decompensation as it began insidiously. The gradual development of cognitive symptoms and the presence of abnormal laboratory results helped identify his deterioration. The current guidelines for the treatment of delirium tremens provide the basis for the management of this highly dangerous disorder. Key Words: Delirium tremens, alcohol withdrawal biomarkers, geriatric delirium
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7

Daghestani, Amin N. "Alcohol withdrawal". Postgraduate Medicine 81, n.º 6 (maio de 1987): 111–18. http://dx.doi.org/10.1080/00325481.1987.11699818.

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8

Saitz, Richard, Lawrence S. Friedman e Michael F. Mayo-Smith. "Alcohol withdrawal". Journal of General Internal Medicine 10, n.º 9 (setembro de 1995): 479–87. http://dx.doi.org/10.1007/bf02602395.

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9

Heo, Kyoung, Yang-Je Cho, So-Hee Eun, Sung Chul Lim, Jeehun Lee e Pamela Song. "Management of Alcohol Withdrawal Syndrome and Alcohol Withdrawal Seizure". Journal of the Korean Neurological Association 35, n.º 3 (1 de agosto de 2017): 121–28. http://dx.doi.org/10.17340/jkna.2017.3.1.

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10

Varghese, Divine, Purnima Ashok, Shristi Nayak, Atul Aby Jacob, K. Vishnu Dev e Vijeesh Thollur. "Drug Utilization Evaluation of Lorazepam in Alcohol Withdrawal Syndrome Patients: A Secondary Care Teaching Hospital Based Study". Journal of Drug Delivery and Therapeutics 10, n.º 2 (15 de março de 2020): 102–6. http://dx.doi.org/10.22270/jddt.v9i4-s.3991.

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Background: Drug utilization evaluation is an important parameter for the safe, effective and rational use of medications in medical care. Alcoholism results in abundant cases of alcohol withdrawal which can prove to be life-threatening if untreated, lorazepam is a drug of choice for Alcohol Withdrawal Syndrome and requires close monitoring as its over-dosing or under-dosing is common in case of withdrawal. Objective: ensures the safe and rational use of Lorazepam in the management of Alcohol Withdrawal Syndrome. Materials and Method: This prospective, observational study was conducted among alcoholic patients admitted in the KC General Hospital, Karnataka, India. Baseline data for Clinical Institute Withdrawal Assessment for Alcohol revised scale (CIWA-Ar) was collected on the day of admission and the response to lorazepam treatment was recorded using the same with respect to the baseline data every 12th hourly after the initial administration until withdrawn. Results: Statistical analysis for 72 patients was done using ANOVA to calculate the overall progression of the syndrome with treatment. Among 72 patients 94.44% were male and 5.55% were female. The mean age of patients reported with AWS was found to be 44.90 years. A significant CIWA-Ar score reduction was observed with a p-value of <0.0001. Conclusion: Our study revealed a strong predominance of male patients with alcohol withdrawal syndrome, where maximum patients started consuming alcohol before the age of 20 years. After the administration of lorazepam, a significant CIWA-Ar score reduction was observed. Keywords: Alcohol Withdrawal Syndrome, CIWA-Ar scale, Drug utilization evaluation, Lorazepam.
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11

Powell, Anne H., e M. Ptlene Minick. "Alcohol Withdrawal Syndrome". American Journal of Nursing 88, n.º 3 (março de 1988): 312. http://dx.doi.org/10.2307/3425762.

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12

Chandran, Dr Rabindran, e Dr D. Sharad Gedam. "Alcohol Withdrawal Syndrome". International Journal of Medical Research and Review 4, n.º 10 (30 de outubro de 2016): 1722–23. http://dx.doi.org/10.17511/ijmrr.2016.i10.01.

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13

Claassen, Cynthia A., e Bryon Adinoff. "Alcohol Withdrawal Syndrome". CNS Drugs 12, n.º 4 (1999): 279–91. http://dx.doi.org/10.2165/00023210-199912040-00003.

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14

Hughes, John R. "Alcohol withdrawal seizures". Epilepsy & Behavior 15, n.º 2 (junho de 2009): 92–97. http://dx.doi.org/10.1016/j.yebeh.2009.02.037.

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15

Vale, Allister. "Alcohol withdrawal syndrome". Foundation Years 4, n.º 2 (abril de 2008): 55–58. http://dx.doi.org/10.1016/j.mpfou.2008.02.010.

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16

Generali, Joyce, e Dennis J. Cada. "Baclofen: Alcohol Withdrawal". Hospital Pharmacy 38, n.º 6 (junho de 2003): 552–55. http://dx.doi.org/10.1177/001857870303800612.

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17

BABB, DELPHINE, e BEVERLY JENKINS. "ALCOHOL WITHDRAWAL SYNDROME". Nursing 20, n.º 10 (outubro de 1990): 33. http://dx.doi.org/10.1097/00152193-199010000-00010.

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18

Brent, Mary Jane. "Unexpected Alcohol Withdrawal". American Journal of Nursing 97, n.º 6 (junho de 1997): 52–53. http://dx.doi.org/10.1097/00000446-199706000-00045.

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19

Matz, Robert. "Alcohol withdrawal syndrome". Lancet 350, n.º 9079 (setembro de 1997): 737. http://dx.doi.org/10.1016/s0140-6736(05)63541-6.

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20

Gillman, Mark A., e Frederick J. Lichtigfeld. "Alcohol withdrawal syndrome". Lancet 350, n.º 9079 (setembro de 1997): 737. http://dx.doi.org/10.1016/s0140-6736(05)63542-8.

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21

Makic, Mary Beth Flynn. "Alcohol Withdrawal Syndrome". Journal of PeriAnesthesia Nursing 32, n.º 2 (abril de 2017): 140–41. http://dx.doi.org/10.1016/j.jopan.2017.01.007.

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22

POWELL, ANNE H., e M. PTLENE MINICK. "ALCOHOL WITHDRAWAL SYNDROME". AJN, American Journal of Nursing 88, n.º 3 (março de 1988): 312–15. http://dx.doi.org/10.1097/00000446-198803000-00022.

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23

Glann, Judith K., Margaret Carman, Julie Thompson, David Olson, Cynthia Nuttall, Holly Fleming e Cheryl Reese. "Alcohol Withdrawal Syndrome". Advanced Emergency Nursing Journal 41, n.º 1 (2019): 65–75. http://dx.doi.org/10.1097/tme.0000000000000226.

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24

Lemon, Stephen J., P. Shane Winstead e Kyle A. Weant. "Alcohol Withdrawal Syndrome". Advanced Emergency Nursing Journal 32, n.º 1 (janeiro de 2010): 20–27. http://dx.doi.org/10.1097/tme.0b013e3181cae050.

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25

&NA;. "Alcohol Withdrawal Syndrome". Advanced Emergency Nursing Journal 32, n.º 1 (janeiro de 2010): 28–29. http://dx.doi.org/10.1097/tme.0b013e3181d88b2e.

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26

Carlson, Richard W., Nivedita N. Kumar, Edna Wong-Mckinstry, Srikala Ayyagari, Nitin Puri, Frank K. Jackson e Shivaramaiah Shashikumar. "Alcohol Withdrawal Syndrome". Critical Care Clinics 28, n.º 4 (outubro de 2012): 549–85. http://dx.doi.org/10.1016/j.ccc.2012.07.004.

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27

Turner, Robert C., Peter R. Lichstein, James G. Peden, Janice T. Busher e Leo E. Waivers. "Alcohol withdrawal syndromes". Journal of General Internal Medicine 4, n.º 5 (setembro de 1989): 432–44. http://dx.doi.org/10.1007/bf02599697.

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28

McMicken, David B. "Alcohol Withdrawal Syndromes". Emergency Medicine Clinics of North America 8, n.º 4 (novembro de 1990): 805–19. http://dx.doi.org/10.1016/s0733-8627(20)30239-x.

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29

Morris, John C., e Maurice Victor. "Alcohol Withdrawal Seizures". Emergency Medicine Clinics of North America 5, n.º 4 (novembro de 1987): 827–39. http://dx.doi.org/10.1016/s0733-8627(21)00018-3.

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30

Trzebiatowska-Trzeciak, Olga, e Grazyna Milewska. "Homœopathic treatment of alcohol withdrawal". British Homeopathic Journal 82, n.º 04 (outubro de 1993): 249–51. http://dx.doi.org/10.1016/s0007-0785(05)80657-x.

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AbstractThe authors report their experience of the treatment of alcohol withdrawal syndrome and delirium tremens (DTs). In a series of 30 alcoholic men (5 with DTs) results appeared favourable. The main homœopathic medicine used was Sulphur.
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31

Haque, Ijasul M., Akhilesh Mishra, Bhupinder Singh Kalra e Shalini Chawla. "Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study". Brain Sciences 11, n.º 7 (12 de julho de 2021): 919. http://dx.doi.org/10.3390/brainsci11070919.

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Patients with alcohol use disorder experience alcohol withdrawal syndrome due to the sudden cessation of alcohol. This study was designed to evaluate the protective effect of Ashwagandha and Brahmi on alcohol withdrawal in rats. Thirty rats of either sex were taken and randomly divided into 6 groups (n = 5). Their normal diet was replaced by a modified liquid diet (MLD). Ethanol was added gradually except in the MLD group for a period of 21 days and withdrawn suddenly. Four treatment groups were administered Ashwagandha (3.75 mg of withanolide glycosides per kg body weight), Brahmi (10 mg of bacosides per kg body weight), Ashwagandha + Brahmi (3.75 mg withanolide glycosides + 10 mg bacosides per kg body weight) orally and diazepam (1 mg/kg body weight, i.p.) 45 min before alcohol withdrawal. Rats were assessed for behavioural changes (agitation score and stereotypic behaviour), anxiety and locomotor activity at 2nd and 6th hours of alcohol withdrawal. Pentylenetetrazol (PTZ) kindling seizures were assessed at 6th hour of alcohol withdrawal. Ashwagandha and Brahmi alone and in combination significantly reduced the behavioural changes in alcohol withdrawal rats at 2nd hour and their combination in 6th hour. Ashwagandha and Brahmi suppressed PTZ kindling seizures effectively and improved locomotory activity at 2nd hour and 6th hour of alcohol withdrawal. Reduction in anxiety was significant among Ashwagandha at 2nd hour and the combination group at 2nd and 6th hour. The results were comparable to diazepam. Ashwagandha and Brahmi have beneficial effects in controlling the behavioural changes, anxiety and seizures in alcohol withdrawal symptoms in rats and improved locomotory activity.
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32

Kampman, Kyle M., Helen Pettinati, Joseph Volpicelli, Gail Kaempf, Ellen Turk, Ambrose Insua, Craig Lipkin, Thorne Sparkman e Charles P. O'Brien. "Concurrent Cocaine Withdrawal Alters Alcohol Withdrawal Symptoms". Journal of Addictive Diseases 21, n.º 4 (20 de setembro de 2002): 13–26. http://dx.doi.org/10.1300/j069v21n04_02.

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33

Aubin, HJ, S. Tilikete, C. Laureaux, HT Nguyen Hac, MC Roullet-Volmi, S. Troupel e D. Barrucand. "Smoking and coffee intake following alcohol withdrawal in alcoholic inpatients". European Psychiatry 10, n.º 8 (1995): 383–85. http://dx.doi.org/10.1016/0924-9338(96)80342-7.

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SummaryThe aim of this study was to assess alcoholic inpatients' smoking and coffee intake variation following withdrawal. Only moderate smokers (less than 30 cigarettes/day) showed a significant increase of cigarette consumption after alcohol withdrawal. However, their urinary cotinine level did not vary, suggesting a behavioral, and not biological, compensation through smoking following alcohol withdrawal. Heavy smokers (30 cigarettes/day or more) showed no significant clinical or biological variation of smoking behavior. Coffee consumption increased after alcohol withdrawal in all patients, irrespective of smoking habits.
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34

Lohr, Robert H. "Alcohol Withdrawal Treatment Manual". Mayo Clinic Proceedings 74, n.º 9 (setembro de 1999): 947–48. http://dx.doi.org/10.4065/74.9.947-b.

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35

Pol, Stanislas. "Dexamethasone for Alcohol Withdrawal". Annals of Internal Medicine 114, n.º 8 (15 de abril de 1991): 705. http://dx.doi.org/10.7326/0003-4819-114-8-705.

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36

Mayo-Smith, Michael. "Alcohol Withdrawal Treatment Manual". Annals of Internal Medicine 131, n.º 12 (21 de dezembro de 1999): 981. http://dx.doi.org/10.7326/0003-4819-131-12-199912210-00020.

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37

Schmidt, L. G., e T. Sander. "Genetics of alcohol withdrawal". European Psychiatry 15, n.º 2 (março de 2000): 135–39. http://dx.doi.org/10.1016/s0924-9338(00)00220-0.

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SummaryAlcohol withdrawal is a clinically and etiologically heterogeneous syndrome caused by a complex interaction of environmental (e.g., amount of ethanol) and genetic factors. Multiple genes are considered to be involved in various components of the syndrome, each of them contributing only modestly to withdrawal vulnerability. Association studies using candidate genes of the dopamine, serotonin, gabaergic and opioidergic systems are reviewed and methodological limitations are discussed.
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38

Curry, Kenneth H. "Choreoathetosis and alcohol withdrawal". Medical Journal of Australia 143, n.º 6 (setembro de 1985): 265–66. http://dx.doi.org/10.5694/j.1326-5377.1985.tb122986.x.

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39

Hall, Wayne, e Deborah Zador. "The alcohol withdrawal syndrome". Lancet 349, n.º 9069 (junho de 1997): 1897–900. http://dx.doi.org/10.1016/s0140-6736(97)04572-8.

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40

Adams, Michael L., e Theodore J. Cicero. "Alcohol Intoxication and Withdrawal". Alcohol 16, n.º 2 (agosto de 1998): 153–58. http://dx.doi.org/10.1016/s0741-8329(97)00185-7.

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41

Walker, Blair, Mary Anderson, Lawrence Hauser e Isela Werchan. "Ethanol for alcohol withdrawal". Journal of Trauma and Acute Care Surgery 74, n.º 3 (março de 2013): 926–31. http://dx.doi.org/10.1097/ta.0b013e3182826df7.

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42

Monroe, Lance E. "Treatment of Alcohol Withdrawal". Southern Medical Journal 84, n.º 7 (julho de 1991): 935. http://dx.doi.org/10.1097/00007611-199107000-00033.

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43

Hodges, Brian M. "Pharmacotherapy for Alcohol Withdrawal". Hospital Pharmacy 38, n.º 5 (maio de 2003): 420–25. http://dx.doi.org/10.1177/001857870303800501.

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This feature examines the impact of pharmacologic interventions on the treatment of the critically ill patient — an area of health care that has become increasingly complex. Recent advances in drug therapy for adult ICU patients (including evolving and controversial data) will be reviewed and assessed in terms of clinical, humanistic, and economic outcomes. Direct questions or comments to Gil Fraser, PharmD, at fraseg@mmc.org .
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44

CASEY-HOUSTON, SHEILA. "ALTERNATIVE FOR ALCOHOL WITHDRAWAL". Nursing 21, n.º 3 (março de 1991): 4. http://dx.doi.org/10.1097/00152193-199103000-00002.

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45

&NA;. "Alcohol Withdrawal and Seizures". Journal of Occupational and Environmental Medicine 31, n.º 11 (novembro de 1989): 888–89. http://dx.doi.org/10.1097/00043764-198911000-00008.

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46

Lerner, William D., e Harold J. Fallon. "The Alcohol Withdrawal Syndrome". New England Journal of Medicine 313, n.º 15 (10 de outubro de 1985): 951–52. http://dx.doi.org/10.1056/nejm198510103131509.

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47

Little, Hilary J., David N. Stephens, Tamzon L. Ripley, Gilyana Borlikova, Theodora Duka, Manja Schubert, Doris Albrecht et al. "Alcohol Withdrawal and Conditioning". Alcoholism: Clinical & Experimental Research 29, n.º 3 (março de 2005): 453–64. http://dx.doi.org/10.1097/01.alc.0000156737.56425.e3.

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48

Gorman, Mary, e Kathryn Babel. "Treating Acute Alcohol Withdrawal". American Journal of Nursing 97, n.º 1 (janeiro de 1997): 22–23. http://dx.doi.org/10.1097/00000446-199701000-00024.

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49

Monte-Secades, R., R. Rabuñal-Rey e H. Guerrero-Sande. "Inpatient alcohol withdrawal syndrome". Revista Clínica Española (English Edition) 215, n.º 2 (março de 2015): 107–16. http://dx.doi.org/10.1016/j.rceng.2014.11.002.

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50

Keys, Vicky A. "Alcohol Withdrawal During Hospitalization". AJN, American Journal of Nursing 111, n.º 1 (janeiro de 2011): 40–44. http://dx.doi.org/10.1097/01.naj.0000393058.86439.9e.

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