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1

National Institute on Alcohol Abuse and Alcoholism (U.S.), ed. Animal models. Public Health Service, National Institutes of Health, 2000.

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2

Joost, Ruitenberg E., and Peters P. W. J, eds. Laboratory animals: Laboratory animal models for domestic animal production. Elsevier Science Publishers, 1986.

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3

Davies, Jamie, ed. Replacing Animal Models. John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119940685.

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4

Technology Information Forecasting and Assessment Council (India), ed. Transgenic animal models. Technology Information, Forecasting, and Assessment Council, 2003.

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5

1948-, Gad Shayne C., and Chengelis Christopher P. 1949-, eds. Animal models in toxicology. M. Dekker, 1992.

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6

King, Aileen J. F., ed. Animal Models of Diabetes. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0385-7.

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7

Risling, Mårten, and Johan Davidsson, eds. Animal Models of Neurotrauma. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9711-4.

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8

Sharpe-Timms, Kathy L., ed. Animal Models for Endometriosis. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51856-1.

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9

Ma, Chao, and Jun-Ming Zhang, eds. Animal Models of Pain. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-880-5.

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10

De Deyn, Peter Paul, and Debby Van Dam, eds. Animal Models of Dementia. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-898-0.

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11

Olivier, B., J. Mos, and J. L. Slangen, eds. Animal Models in Psychopharmacology. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-6419-0.

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12

Koob, George F., Cindy L. Ehlers, and David J. Kupfer, eds. Animal Models of Depression. Birkhäuser Boston, 1989. http://dx.doi.org/10.1007/978-1-4684-6762-8.

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13

Baraban, Scott C., ed. Animal Models of Epilepsy. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-263-6.

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14

F, Koob George, Ehlers Cindy L, Kupfers David J. 1941-, and MacArthur Foundation Research Network on the Psychobiology of Depression., eds. Animal models of depression. Birhäuser, 1989.

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15

Huub, Schellekens, Horzinek Marian C, and Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek., eds. Animal models in AIDS. Elsevier, 1990.

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16

1948-, Gad Shayne C., ed. Animal models in toxicology. 2nd ed. Taylor & Francis, 2006.

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17

1947-, Baker Glen B., Boulton A. A, and Martin-Iverson Mathew Thomas 1956-, eds. Animal models in psychiatry. Humana Press, 1991.

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18

Debby, Van Dam, ed. Animal Models of Dementia. Humana Press, 2011.

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19

Vijayakumar Sreelatha, Harikrishnan, Satish Patel, and Perumal Nagarajan, eds. Animal Models in Research. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-0048-6.

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20

Berend, Olivier, Mos J, Slangen Jef L, and International Congress of Pharmacology (11th : 1990 : Amsterdam, Netherlands), eds. Animal models in psychopharmacology. Birkhäuser, 1991.

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21

F, Sima Anders A., and Shafrir Eleazar, eds. Animal models of diabetes: A primer. Harwood Academic, 2001.

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22

1937-, Miyaji Makoto, ed. Animal models in medical mycology. CRC Press, 1987.

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23

Gross, David R. Animal models in cardiovascular research. 3rd ed. Springer, 2009.

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24

Avena, Nicole M. Animal models of eating disorders. Humana Press, 2013.

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25

Boulton, Alan A., Glen B. Baker, and Mathew T. Martin-Iverson. Animal Models in Psychiatry, II. Humana Press, 1991. http://dx.doi.org/10.1385/0896031772.

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26

Boulton, Alan A., Glen B. Baker, and Mathew T. Martin-Iverson. Animal Models in Psychiatry, I. Humana Press, 1991. http://dx.doi.org/10.1385/0896031985.

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27

Boulton, Alan A., Glen B. Baker, and Peter H. Wu. Animal Models of Drug Addiction. Humana Press, 1992. http://dx.doi.org/10.1385/0896032175.

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28

Alper, Joe, Lida Anestidou, and Jenna Ogilvie, eds. Animal Models for Microbiome Research. National Academies Press, 2018. http://dx.doi.org/10.17226/24858.

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29

Gross, David. Animal Models in Cardiovascular Research. Springer US, 2009. http://dx.doi.org/10.1007/978-0-387-95962-7.

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30

Martínez Murillo, Ricardo, and Alfredo Martínez, eds. Animal Models of Brain Tumors. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-209-4.

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31

Gross, David R. Animal Models in Cardiovascular Research. Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-5006-1.

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32

Joost, Hans-Georg, Hadi Al-Hasani, and Annette Schürmann, eds. Animal Models in Diabetes Research. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-068-7.

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33

Avena, Nicole M., ed. Animal Models of Eating Disorders. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-104-2.

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34

Pittenger, Christopher, Stephanie Dulawa, and Summer L. Thompson. Animal Models of OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0029.

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Obsessive-compulsive disorder and related conditions are characterized by demonstrable alterations in brain function, and aspects of these may, in principle, be recapitulated and studied in animals. However, the relationship between animal models and the clinical syndrome is complex. Many clinical aspects of OCD, especially those that can only be evaluated by subjective report, cannot be assessed in an animal. As a result, some discount the utility of animal modeling of OCD altogether. However, conservation of both genes and brain anatomy across mammalian species supports the opposite perspect
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35

Animal models. Public Health Service, National Institutes of Health, 2000.

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36

Torres-Ruiz, Raul, and Sandra Rodriguez-Perales. CRISPR in Animals and Animal Models. Elsevier Science & Technology Books, 2017.

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37

Torres-Ruiz, Raul, and Sandra Rodriguez-Perales. CRISPR in Animals and Animal Models. Elsevier Science & Technology Books, 2017.

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38

Crabbe, John C., and Tamara J. Phillips. Genetic Animal Models. Edited by Kenneth J. Sher. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199381678.013.003.

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Genetic animal models have a long history of contribution to the understanding of alcohol dependence. Studies have provided insight into genetic contributions to risk and are beginning to be used to suggest better targeted pharmacotherapies. This review discusses how different species and genetic methods have been used to target specific aspects of alcohol dependence. It identifies areas of future promise and those in which more information is needed. It considers how genetic and environmental sources interact to affect risk and treatment response. The review concentrates on alcohol because th
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39

Baglietto-Vargas, David, Rahasson R. Ager, Rodrigo Medeiros, and Frank M. LaFerla. Animal Models of Neurodegenerative Diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0014.

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The incidence and prevalence of neurodegenerative disorders (e.g., Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), etc.) are growing rapidly due to increasing life expectancy. Researchers over the past two decades have focused their efforts on the development of animal models to dissect the molecular mechanisms underlying neurodegenerative disorders. Existing models, however, do not fully replicate the symptomatic and pathological features of human diseases. This chapter focuses on animal models of AD, as this disorder is the most prevalent of the brain degen
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40

Perkins, Elizabeth C., Shaun P. Brothers, and Charles B. Nemeroff. Animal Models for Post-Traumatic Stress Disorder. Edited by Charles B. Nemeroff and Charles R. Marmar. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190259440.003.0024.

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Animal models of post-traumatic stress disorder (PTSD) provide a wellspring of biological information about this complex condition by providing the opportunity to manipulate trauma exposure and measure biological outcomes in a systematic manner that is not possible in clinical studies. Symptoms of PTSD may be induced in animals by physical (immobilization, foot shock, underwater stress) and psychological stressors (exposure to predator, social defeat, early life trauma) or a combination of both. In addition, genetic, epigenetic and transgenic models have been created by breeding animals with a
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41

Dodman, Nicholas H., and Louis Shuster. Spontaneously Occurring Animal Models of OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0032.

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This chapter summarizes what we know about compulsive behavioral disorders in several animal species. Animals can develop repetitive behaviors in a range of circumstances, generally associated with anxiety or stress. It is increasingly apparent that these behaviors recapitulate core features of obsessive-compulsive disorder. They are clearly partially genetic; for example, specific breeds of dog are susceptible to specific compulsive behavioral disorders. Understanding such OCD-like behaviors provides a potentially fruitful avenue towards understanding OCD in humans. This chapter reviews this
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42

Gad, Shayne C. Animal Models in Toxicology. 2nd ed. CRC, 2006.

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43

Animal models in toxicology. 2nd ed. CRC Press/Taylor & Francis, 2006.

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44

Keehn, J. D. Animal Models for Psychiatry. Taylor & Francis Group, 2018.

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45

Lu, Bingwei. Animal Models of Neurodegeneration. Wiley & Sons, Incorporated, John, 2016.

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46

Gad, Shayne C., ed. Animal Models in Toxicology. CRC Press, 2006. http://dx.doi.org/10.1201/9781420014204.

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47

Christopher, Evans J., Brigitte L. Kieffer, David Jentsch, and Rafael J. Maldonado. Animal Models of Addiction. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0043.

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Drug addiction, now officially diagnosed as substance use disorder (SUD), is a chronic brain syndrome characterized by the compulsive use of drugs, loss of control over drug taking in spite of its adverse consequences, and relapse even after long periods of drug abstinence. Animal models have played a critical role in our understanding of the molecules, circuits, and behaviors associated with substance use disorders. This chapter reviews animal models that have been widely used to assess all stages of the addiction cycle: from drug initiation, through drug seeking, to withdrawal and relapse. W
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48

Gad, Shayne C., and Shayne C. Gad, eds. Animal Models in Toxicology. CRC Press, 2016. http://dx.doi.org/10.1201/b18705.

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49

Animal models in psychiatry. Humana, 1991.

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50

Keehn, J. D. Animal Models for Psychiatry. Routledge, 2018. http://dx.doi.org/10.4324/9780203712436.

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