Bibliografias temáticas / Anticancer efficacy

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Literatura científica selecionada sobre o tema "Anticancer efficacy"

Autor: Grafiati
Publicado: 7 de junho de 2025
Última modificação: 2 de agosto de 2025

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Artigos de revistas sobre o assunto "Anticancer efficacy"

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Kisiel-Nawrot, Ewa, Malgorzata Latocha, Andrzej Bak, Violetta Kozik, Josef Jampilek, and Andrzej Zieba. "Anticancer Efficacy of Antibacterial Quinobenzothiazines." Applied Sciences 13, no. 5 (2023): 2886. http://dx.doi.org/10.3390/app13052886.

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The antitumor potency of a series of designed and prepared antibacterial quinobenzothiazines was evaluated against different types of human cancer cell lines, such as glioblastoma SNB-19, lung adenocarcinoma A549 and breast cancer T47D, and the activities of the compounds were compared to cisplatin and doxorubicin. 9-Propoxy-5-methyl-12H-quino[3,4-b][1,4]benzo- thiazinium chloride (4a), 9-allyloxy-5-methyl-12H-quino[3,4-b][1,4]benzothiazinium chloride (4d) and 11-benzyloxy-5-methyl-12H-quino[3,4-b][1,4]benzothiazinium chloride (4l) were the most active compounds; their IC50 values against all
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Farashi-Bonab, Samad, and Nemat Khansari. "Salmonella-based Anticancer Vaccines and their Efficacy." Vaccination Research – Open Journal 4, no. 1 (2019): 5–11. http://dx.doi.org/10.17140/vroj-4-111.

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Surgery, chemotherapy, and radiotherapy are successfully used to treat patients with tumors or cancers. However, the innovation of more potent therapeutic modalities is essential for the efficient treatment of patients with advanced cancers. More than two centuries ago, bacteria have been observed to have beneficial effects in some cancer patients. Virulence factors of some bacteria and their infectious behavior in the body suggest their effectiveness in tumor suppression. At present, bacillus calmette-guérin (BCG), a live attenuated strain of Mycobacterium bovis, is currently used to treat bl
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Niedzwiecki, Aleksandra, Mohd Roomi, Tatiana Kalinovsky, and Matthias Rath. "Anticancer Efficacy of Polyphenols and Their Combinations." Nutrients 8, no. 9 (2016): 552. http://dx.doi.org/10.3390/nu8090552.

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Sun, Shi-Yong. "Enhancing perifosine's anticancer efficacy by preventing autophagy." Autophagy 6, no. 1 (2010): 184–85. http://dx.doi.org/10.4161/auto.6.1.10816.

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Fu, Chih-Wei, Yun-Jung Hsieh, Tzu Ting Chang, et al. "Anticancer efficacy of unique pyridine-based tetraindoles." European Journal of Medicinal Chemistry 104 (November 2015): 165–76. http://dx.doi.org/10.1016/j.ejmech.2015.09.032.

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Alven, Sibusiso, and Blessing Atim Aderibigbe. "The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment." Pharmaceutics 12, no. 12 (2020): 1212. http://dx.doi.org/10.3390/pharmaceutics12121212.

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Breast cancer is among the most common types of cancer in women and it is the cause of a high rate of mortality globally. The use of anticancer drugs is the standard treatment approach used for this type of cancer. However, most of these drugs are limited by multi-drug resistance, drug toxicity, poor drug bioavailability, low water solubility, poor pharmacokinetics, etc. To overcome multi-drug resistance, combinations of two or more anticancer drugs are used. However, the combination of two or more anticancer drugs produce toxic side effects. Micelles and dendrimers are promising drug delivery
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Li, Fan, Xinqing Fu, Qingqing Huo, and Wantao Chen. "Research Progress on the Nano-Delivery Systems of Antitumor Drugs." Nano LIFE 10, no. 01n02 (2020): 2040006. http://dx.doi.org/10.1142/s1793984420400061.

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To date, chemotherapy, the main treatment for malignant tumors, still fails to provide ideal therapeutic efficacy, which is deeply rooted in various physiological barriers, either temporal or spatial, to the delivering of anticancer drugs to solid tumor sites during chemotherapy. In the meantime, the therapeutic efficacy of anticancer drugs is affected by inherent cancer characteristics, drug transport, cellular uptake and other complex interactions. Recently, advances have been constantly achieved on nanoscale drug delivery systems (NDDSs) for anticancer drug delivery, driven by their excelle
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Xu, Tengyan, Chunhui Liang, Debin Zheng, et al. "Nuclear delivery of dual anticancer drug-based nanomedicine constructed by cisplatinum-induced peptide self-assembly." Nanoscale 12, no. 28 (2020): 15275–82. http://dx.doi.org/10.1039/d0nr00143k.

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Verma, Poonam, Sanjukta Naik, Pranati Nanda, Silvi Banerjee, Satyanarayan Naik, and Amit Ghosh. "In Vitro Anticancer Activity of Virgin Coconut Oil and its Fractions in Liver and Oral Cancer Cells." Anti-Cancer Agents in Medicinal Chemistry 19, no. 18 (2020): 2223–30. http://dx.doi.org/10.2174/1871520619666191021160752.

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Background: Coconut oil is an edible oil obtained from fresh, mature coconut kernels. Few studies have reported the anticancer role of coconut oil. The fatty acid component of coconut oil directly targets the liver by portal circulation and as chylomicron via lymph. However, the anti-cancer activity of coconut oil against liver cancer cells and oral cancer cells is yet to be tested. The active component of coconut oil, that is responsible for the anticancer activity is not well understood. In this study, three different coconut oils, Virgin Coconut Oil (VCO), Processed Coconut Oil (PCO) and Fr
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Safwat, Mohamed A., Bothaina A. Kandil, Mohamed A. Elblbesy, Ghareb M. Soliman, and Nermin E. Eleraky. "Epigallocatechin-3-Gallate-Loaded Gold Nanoparticles: Preparation and Evaluation of Anticancer Efficacy in Ehrlich Tumor-Bearing Mice." Pharmaceuticals 13, no. 9 (2020): 254. http://dx.doi.org/10.3390/ph13090254.

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Epigallocatechin-3-gallate (EGCG) is a pleiotropic compound with anticancer, anti-inflammatory, and antioxidant properties. To enhance EGCG anticancer efficacy, it was loaded onto gold nanoparticles (GNPs). EGCG-GNPs were prepared by a simple green synthesis method and were evaluated using different techniques. Hemocompatibility with human blood and in vivo anticancer efficacy in Ehrlich ascites carcinoma-bearing mice were evaluated. EGCG/gold chloride molar ratio had a marked effect on the formation and properties of EGCG-GNPs where well-dispersed spherical nanoparticles were obtained at a mo
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Teses / dissertações sobre o assunto "Anticancer efficacy"

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Haglund, Caroline. "Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications." Doctoral thesis, Uppsala universitet, Klinisk farmakologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150361.

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Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. A high correlation was seen when comparing the 50% inhibitory concentrations (IC50) from FMCA-GM with the IC50 from the established clonogenic assay (CFU-GM). In paper II, FMCA-GM was complemented with additional cell models, establishing a normal cell pa
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Hansson, Emma K. "Pharmacometric Models for Biomarkers, Side Effects and Efficacy in Anticancer Drug Therapy." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170738.

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New approaches quantifying the effect of treatment are needed in oncology to improve the drug development process and to enable treatment optimization for existing therapies. This thesis focuses on the development of pharmacometric models for biomarkers, side effects and efficacy in order to identify predictors of clinical response in anti-cancer drug therapy. The variability in myelosuppression was characterized in six different cytotoxic anticancer treatments to evaluate a model-based dose individualization approach utilizing neutrophil counts as a biomarker. The estimated impact of inter-oc
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Xia, Yixuan. "Anticancer efficacy and mechanism of action studies of the potent plant cycloheptapeptide compounds mavacyocines." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/817.

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Over the past 200 years, much attention has been paid to natural products for their great contribution in the industry of drug development as many of them have been shown effective against various diseased conditions in humans by virtue of their structural diversity and biological potency. Therefore, they are undeniably a rich resource for the discovery of novel bioactive compounds. To date, many of the mainstay anticancer agents often lead to undesirable side effects and/or develop rapid emergence of drug resistance. Therefore, new therapeutic remedies are desperately needed. In fact, many ac
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Maldonado, Arturo R. "Molecular Targeting and Enhancing Anticancer Efficacy of Oncolytic HSV-1 to Midkine Expressing Tumors." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298041800.

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Parkkola, Hanna. "Hyaluronic acid-coated gold nanoparticles as an anticancer drug delivery system - Biological characterization and efficacy." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285100.

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Novel stategies are needed to improve the limited efficacy of current cancer therapies. High expectations are directed towards nanotechnology-based applications in cancer medicine. We have developed a drug delivery system based on hyaluronic acid (HA) ­coated gold nanoparticles (AuNPs) that targets CD44, a cell surface glycoprotein overexpressed by various cancer cells. This nanocarrier (EDS: Endor Drug Delivery System) provides a platform for the conjugation of anticancer agents for a more efficient cancer treatment. We show that the unique characteristics of AuNPs remain unchanged when the
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Du, Plessis-Stoman Debbie. "A combination of platinum anticancer drugs and mangiferin causes increased efficacy in cancer cell lines." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/d1016160.

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This thesis mainly deals with some biochemical aspects regarding the efficacy of novel platinum anticancer compounds alone and in combination with mangiferin, as part of a broader study in which both chemistry and biochemistry are involved. Various novel diamine and N-S donor chelate compounds of platinum II and IV have been developed in which factors such as stereochemistry, ligand exchange rate and biocompatibility were considered as additional parameters. In the first order testing, each of these compounds was tested with reference to their “killing” potential by comparing their rate of kil
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Sarwar, Md Shahid. "Elucidation of anticancer efficacy of ent-kaurane diterpenes through structure-activity relationship and mechanism of action studies." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/669.

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Colorectal cancer (CRC) is the third most prevalent and second leading causes of cancer-associated deaths globally. Over the last few decades, ent-kaurane diterpenes have been widely investigated for their anticancer potentials. Flexicaulin A (9) is a naturally occurring ent-kaurane. Previously, our lab modified the structure of 9 by replacing the C-11 hydroxyl group with carbonyl group and obtained a novel compound oxoflexicaulin A (11). However, anticancer activities and mechanistic pathway of these two compounds are yet to be explored. In the current thesis, we evaluated the cytotoxicity of
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Koot, Dwayne Jonathan. "Strategic pre-clinical development of Riminophenazines as resistance circumventing anticancer agents." Thesis, University of Pretoria, 2012. http://hdl.handle.net/2263/24163.

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Cancer is responsible for upward of 13% of human deaths. Contemporary chemotherapy of disseminated cancer is often thwarted by dose limiting systemic toxicity and by multi-drug resistance (MDR). Riminophenazines are a novel class of potential anticancer agents that possess a potent multi-mechanistic antineoplastic action. Apart from their broad action against intrinsic, non-classical resistance, Riminophenazines inhibit the action of Pgp and hypothetically all ABC transporters demonstrating their great utility against classical MDR. Considering that combination chemotherapy is the norm, the vi
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Koegle, Eric Richard. "Determining the Intracellular Localization and Efficacy of Novel Anticancer Agents in Human Breast Cancer Cell Lines Through the Use of Fluorescent Microscopy." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1234749487.

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Thesis (M.S.)--University of Toledo, 2008.<br>Typescript. "Submitted as partial fulfillments of the requirements for The Master of Science in Pharmaceutical Sciences in Pharmacology and Toxicology." "A thesis entitled"--at head of title. Bibliography: leaves 47-49.
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Soble, Michelle Joy 1961. "THE EFFECTS OF GLUTATHIONE DEPLETION BY L-BUTHIONINE-(S,R) SULFOXIMINE ON THE ANTITUMOR EFFICACY OF MODEL SULFHYDRYL-DEPENDENT ANTICANCER AGENTS (BSO)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276859.

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Capítulos de livros sobre o assunto "Anticancer efficacy"

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Mravec, Boris. "Influencing the Efficacy of Anticancer Treatments." In Neurobiology of Cancer. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-68590-3_55.

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Klinger, Neil V., and Sandeep Mittal. "Anticancer Properties of Curcumin and Its Efficacy for Treating Central Nervous System Neoplasms." In Anticancer plants: Properties and Application. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8548-2_15.

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Kumar, Sushil, Komal Raina, and Rajesh Agarwal. "Chemopreventive and Anticancer Efficacy of Silibinin Against Colorectal Cancer." In Multi-Targeted Approach to Treatment of Cancer. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-12253-3_21.

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Pimm, M. V., J. A. Clegg, M. C. Garnett, and R. W. Baldwin. "Biodistribution and Therapeutic Efficacy of a Monoclonal Antibody-Methotrexate Conjugate in Mice." In Human Tumour Xenografts in Anticancer Drug Development. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73252-2_17.

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Duvey, Anuradha, Divya Chauhan, Nitin Gupta, and Vipendra Kumar Singh. "Porous Carbon Materials Enhanced the Therapeutic Efficacy of Anticancer Drugs." In Materials Horizons: From Nature to Nanomaterials. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-7188-4_33.

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Siddiqui, Nahida, Lubna Abidin, Nazima Nisar, Irfan Ahmad, and Ali Nasir Siddiqui. "Flavonoids Targeting Cancer Stem Cells: A Paradigm to Anticancer Efficacy." In Polyphenols-based Nanotherapeutics for Cancer Management. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-4935-6_7.

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Kaushik, Ayansh, Sudhanshu Mallan, Shivani Chib, Kanupriya Chauhan, and Shamsher Singh. "Genetic Modulation of Anticancer Drugs Affecting Pharmacokinetic for Safety and Efficacy." In Handbook of Oncobiology: From Basic to Clinical Sciences. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-2196-6_55-1.

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Ganai, Shabir Ahmad. "Combining Histone Deacetylase Inhibitors with Other Anticancer Agents as a Novel Strategy for Circumventing Limited Therapeutic Efficacy and Mitigating Toxicity." In Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-8179-3_10.

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García-Campelo, Rosario, Miquel Tarón, Itziar De Aguirre, Pedro Méndez, and Rafael Rosell. "Genotypes That Predict Toxicity and Genotypes That Predict Efficacy of Anticancer Drugs." In Principles of Molecular Oncology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-470-4_19.

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Hong, Jie, and Jing-Yuan Fang. "Gut Microbiota Impacts on the Efficacy of Anticancer Treatment of Colorectal Cancer." In Microbiome in Gastrointestinal Cancer. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-4492-5_15.

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Trabalhos de conferências sobre o assunto "Anticancer efficacy"

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Siu, Annie Fung-Ming, and Duncan Chung-Hang Leung. "Abstract 3525: Molecular determinants of the anticancer efficacy of indenoisoquinolines." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3525.

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Arpaci, Pembegul Uyar, Pembegul Uyar Arpaci, Fatih Ozcan, Emine Gok, Fatih Ozcan, and Seref Ertul. "Improved anticancer efficacy of p-tert-butylcalix[4]arene through surface modifications." In 2017 IEEE 7th International Conference "Nanomaterials: Application & Properties" (NAP). IEEE, 2017. http://dx.doi.org/10.1109/nap.2017.8190338.

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Warsito, Warsito, Masruri Masruri, Sinta Murlistyarini, Dwika Putri Pangesti, and Asyfariatus Zulfa Azhar. "Screening Multitarget Anticancer Compounds from Salicylic Acid Derivatives: (Without and with Amino Acid Linkage) by <i>In Silico</i> Docking." In International Conference on Chemistry and Material Sciences 2023 (IC2MS). Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-svkm5p.

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This research aims to design anticancer molecules using the hybridization concept based on molecular derivatives of salicylic acid. The investigation explores structures with and without linked amino acid alanine through an in-silico docking approach. The research conducts screenings of the designed salicylic acid derivative molecules against receptors, including MMP9, MMP2, CDK2, P53, BAK EGFR, and ADP Ribose Polymerase. The most promising docking results for multitarget cancer compounds were observed in salicylic acid derivatives with amino acid linkages, specifically salicylic acid-curcumin
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Tsibulak, I., J. Hagenbuchner, M. Ausserlechner, et al. "713 Palbociclib and metformin show anticancer efficacy in high grade serous ovarian cancer." In ESGO 2021 Congress. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/ijgc-2021-esgo.451.

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Jovičić Milić, Sandra S., Marko Antonijević, Đorđe S. Petrović, Verica V. Jevtić, and Danijela Lj Stojković. "Investigation of the anticancer activity of 2-amino-6-methylbenzothiazole and corresponding Pd(II) complex using molecular docking simulations." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.535jm.

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In our prior investigations, it has been established that compound di(2-amino-6-methylbenzothiazole)dichloridopalladate(II) (C1) exhibits promising efficacy in inhibiting the growth of colon carcinoma, thereby demonstrating potential as an anticancer agent. To elucidate the underlying mechanism of action against cancer, a comprehensive investigation involving DNA binding analysis and a series of assays to evaluate the inhibitory potential of compound C1 against key proteins involved in cancer metabolism were conducted. The significant inhibitory potential of C1 towards Bcl-2, Ki-67, and CDK-4
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Ying, Wenbin, Jihua Liu, Kwok Yin Tsang, et al. "Abstract 4578: A novel polymer-anticancer drug micelle formulation showing enhanced efficacy over Abraxane." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4578.

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Yeon, Sang-Eun, Sang-Hoon Lee, and Hyo-Jeong Kuh. "Abstract 2722: Characteristics of pancreatic cancer spheroids as a model for anticancer efficacy test." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2722.

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Fofaria, Neel, Alok Ranjan, Hussaini Syed Sha Qhattal, Xinli Liu, and Sanjay K. Srivastava. "Abstract 2062: Nanoemulsion formulations for anticancer agent piplartine characterization, toxicological, pharmacokinetics and efficacy studies." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2062.

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Appendino, G., A. Pagani, C. Williams, et al. "Chemistry, mode of action and clinical efficacy of the anticancer diterpenoid tigilanol tigliate (EBC-46)." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399676.

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Nisshanthini, S. D., R. Sukirtha, S. Achiraman, M. Palaniswamy, and Angayarkanni Jayaraman. "Abstract B250: Evaluation of anticancer efficacy of 6-propionylpterin characterized from native isolate Bacillus subtilis." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-b250.

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Relatórios de organizações sobre o assunto "Anticancer efficacy"

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Inoue, Takashi, and Mamoru Narukawa. Anti-tumor efficacy of anti-PD-1/PD-L1 antibodies in combination with other anticancer drugs in solid tumors: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.10.0004.

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Review question / Objective: The aim of this systematic review is to compare the combination of PD-1/PD-L1 inhibitors plus other anticancer drugs and monotherapies of PD-1/PD-L1 inhibitors in terms of antitumor efficacy in the solid tumors to better inform clinical practice. To this end, the proposed systematic review will address the following question: Which is the best choice to enhance response rate in subjects with solid tumors, PD-1/PD-L1 inhibitors plus cytotoxic agents or PD-1/PD-L1 inhibitors plus other targeted anticancer drugs? Condition being studied: Cancer is the leading cause of
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Chaudhuri, Gautam. Enhancement of the Efficacy of Conventional Anticancer Compounds through the Repression of SNAI Proteins in Aggressive Breast Cancer Cells. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada572979.

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Chen, Xiaole, Peng Wang, Yunquan Luo, et al. Therapeutic Efficacy Evaluation and Underlying Mechanisms Prediction of Jianpi Liqi Decoction for Hepatocellular Carcinoma. Science Repository, 2021. http://dx.doi.org/10.31487/j.jso.2021.02.04.sup.

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Objective: The aim of this study was to assess the therapeutic effects of Jianpi Liqi decoction (JPLQD) in hepatocellular carcinoma (HCC) and explore its underlying mechanisms. Methods: The characteristics and outcomes of HCC patients with intermediate stage B who underwent sequential conventional transcatheter arterial chemoembolization (cTACE) and radiofrequency ablation (RFA) only or in conjunction with JPLQD were analysed retrospectively. The plasma proteins were screened using label-free quantitative proteomics analysis. The effective mechanisms of JPLQD were predicted through network pha
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