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Artigos de revistas sobre o tema "Antidiabetic evaluation"

Autor: Grafiati

Publicado: 7 de junho de 2025

Última modificação: 2 de agosto de 2025

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1

Alqahtani, Ali S., Riaz Ullah, and Abdelaaty A. Shahat. "Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia." Evidence-Based Complementary and Alternative Medicine 2022 (January 17, 2022): 1–23. http://dx.doi.org/10.1155/2022/7123521.

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The purpose of this review is to summarize the available antidiabetic medicinal plants in the Kingdom of Saudi Arabia with its phytoconstituents and toxicological findings supporting by the latest literature. Required data about medicinal plants having antidiabetic activities and growing in the Kingdom of Saudi Arabia were searched/collected from the online databases including Wiley, Google, PubMed, Google Scholar, ScienceDirect, and Scopus. Keywords used in search are in vivo antidiabetic activities, flora of Saudi Arabia, active ingredients, toxicological evaluations, and medicinal plants. A

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Patiram Harijan, Pushpa, Ran Vijay Singh, and Sanjay Kumar Kushwaha. "Preparation and Evaluation of Novel Floating Mucoadhesive Antidiabetic Tablets." International Journal of Science and Research (IJSR) 12, no. 9 (2023): 1856–60. http://dx.doi.org/10.21275/sr23613180139.

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Jyoti, Mandal* Anil Sori Tulsidas Nimbekar. "Formulation And Evaluation of Hibiscus Tea Granules Powder." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3591–98. https://doi.org/10.5281/zenodo.15479914.

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The present study aimed to formulate, develop, and evaluate a herbal tea granule preparation composed of Hibiscus rosa-sinensis (Java), Zingiber officinale (Ginger), Elettaria cardamomum (Cardamon), and Stevia rebaudiana (Stevia), targeting potential antidiabetic effects. Each of these herbs has been traditionally recognized for its antidiabetic properties, and their combination was hypothesized to exert enhanced synergistic effects. A total of nine formulation, differing in the properties of herbal components. Hibiscus rosa-sinensis has also been widely used in herbal teas and beverages. Seve

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Karra, Geetha, Vudutha Bhavani, RS Kiran, and TR Rao. "Formulation and Evaluation of Polyherbal Antidiabetic Capsules." Journal of Advanced Scientific Research 15, no. 03 (2024): 22–28. http://dx.doi.org/10.55218/jasr.2024150305.

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This research aims to create and assess polyherbal anti-diabetic capsules using medicinal plants with anti-diabetic properties. The formulation process involves carefully choosing botanical extracts with antidiabetic properties, verifying their bioactive compounds, and blending them to form a polyherbal blend with maximum antidiabetic potential while ensuring safety.Micro Crystalline Cellulose is used in encapsulating a polyherbal mix for stability, release, and patient convenience. Capsule dosage form is recommended for improved treatment adherence. Efficiency is assessed through in vitro stu

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Soltaninejad, Hossein, Hadi Zare-Zardini, Mahtab Ordooei, et al. "Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis." Journal of Diabetes Research 2021 (June 29, 2021): 1–10. http://dx.doi.org/10.1155/2021/2894722.

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Antimicrobial peptides, as an important member of the innate immune system, have various biological activities in addition to antimicrobial activity. There are some AMPs with antidiabetic activity, especially those isolated from amphibians. These peptides can induce insulin release via different mechanisms based on peptide type. In this review study, we collected all reported AMPs with antidiabetic activity. We also analyze the sequence and structure of these peptides for evaluation of sequence and structure effect on their antidiabetic activity. Based on this review, the biggest peptide famil

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Vázquez, Citlali, Rusely Encalada, Isabel Jiménez-Galicia, et al. "Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for Trypanosoma cruzi Infection." Pharmaceuticals 18, no. 1 (2024): 21. https://doi.org/10.3390/ph18010021.

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Infection with the protozoan parasite Trypanosoma cruzi causes human Chagas disease. Benznidazole (BNZ) and nifurtimox are the current drugs for the treatment; however, they induce severe adverse side effects in patients; therefore, there is a need to improve the treatment effectiveness and efficiency of these drugs for its safer use. Background/Objective: Glyburide, glipizide, and gliquidone, hypoglycemic drugs for diabetes treatment, were previously predicted to bind to dihydrofolate reductase-thymidylate synthase from T. cruzi by in silico docking analysis; they also showed antiproliferativ

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Thapa, Chandra Bahadur, Anjana Bhattarai, Krishna Kumar Pant, Hari Datta Bhattarai, and Bijaya Pant. "Evaluation of Antioxidant, Antidiabetic, and Cytotoxic Activities of Lilium nepalense D. Don." Journal of Institute of Science and Technology 28, no. 2 (2023): 63–70. http://dx.doi.org/10.3126/jist.v28i2.61174.

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Lilium nepalense, a temperate medicinal plant, is used as a diuretic, antipyretic, tonic, flavoring agent, and heart pain treatment. This research aimed to evaluate the in vitro antioxidant and antidiabetic activities of the methanol, dichloromethane (DCM), and hexane fractions, and in vivo cytotoxic activities of the crude extracts of the bulb. The antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, antidiabetic activity by α-glucosidase inhibitory assay, and cytotoxic activity in terms of LC50 (median lethality concentration) by Brine shrimp assay. The DCM fracti

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Vallinayaki, KN, and Rajeshkumar Shanmugam. "Evaluation of Antidiabetic Activity and Cytotoxic Effect of Strontium Nanoparticles Synthesized Using Mimosa Pudica." Journal of Pharmacy and Bioallied Sciences 16, Suppl 2 (2024): S1340—S1344. http://dx.doi.org/10.4103/jpbs.jpbs_583_23.

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ABSTRACT Nanotechnology is emerging as a promising approach in the development of novel therapeutic strategies. Nanoparticles, due to their unique physicochemical properties and small size, have the potential to improve the delivery of therapeutic agents, enhance their bioavailability, and increase their efficacy. Among various types of nanoparticles, strontium nanoparticles have gained attention due to their potential antidiabetic activity and cytotoxic effects against cancer cells. Mimosa pudica, also known as “Sensitive Plant” or “Touch-Me-Not,” is a medicinal plant known for its diverse ph

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Dattatraya, Sable Kundan, Sable Kiran Dattatray, Kathwate Ganesh Sunil, and Mane Snehal Suryakant. "Formulation and evaluation of herbal antidiabetic tablet." Asian Journal of Research in Pharmaceutical Science 10, no. 3 (2020): 145. http://dx.doi.org/10.5958/2231-5659.2020.00027.2.

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Jonatas, Kay Ann S., Joseph Mari B. Querequincia, Shiela D. Miranda, Ukoba Obatavwe, Mary Jho-Anne Corpuz, and Ross D. Vasquez. "Antidiabetic evaluation of Artocarpus odoratissimus (Moraceae) fruit." Jurnal Ilmiah Farmasi 16, no. 1 (2020): 1–8. http://dx.doi.org/10.20885/jif.vol16.iss1.art1.

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Mariappan, G., P. Prabhat, L. Sutharson, J. Banerjee, U. Patangia, and S. Nath. "Synthesis and Antidiabetic Evaluation of Benzothiazole Derivatives." Journal of the Korean Chemical Society 56, no. 2 (2012): 251–56. http://dx.doi.org/10.5012/jkcs.2012.56.2.251.

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Shaikh, Parvin, Manasi Lokare, Mrunal Bhoge, Nalina Rajmane, Nandini Avadhut, and Nikhil Thavare. "Formulation and evaluation of antidiabetic polyherbal syrup." Journal of Pharmacognosy and Phytochemistry 13, no. 2 (2024): 10–17. http://dx.doi.org/10.22271/phyto.2024.v13.i2a.14865.

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Sushant, Kaluram Bhondave, S. Popade Vishal, B. Salunke Shantanu, Barve Suyash, and Akotkar Roshan. "Formulation and Evaluation of Herbal Antidiabetic Tea Granules Powder." International Journal of Innovative Science and Research Technology (IJISRT) 10, no. 1 (2025): 2743–49. https://doi.org/10.5281/zenodo.14891753.

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The goal of the current study was to create, develop, and assess a polyherbal tea granule formulation that combined Aegle marmelos (Belpatra), Momordica charantia (Karela), Tinospora cordifolia (Guduchi), Eugenia jambolana (Jamun), and Stevia rebaudiana (Stevia) for possible antidiabetic benefits. These traditionally used herbs have all demonstrated potential as antidiabetic agents, and their combined effects may be more potent. Nine formulations (F1–F9) with varying herb quantities were made using solvent extraction, and the findings were standardized using HPLC. The optimized formulati

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Anushree, Suga1 Ashwini Paschapur1 Somashekhar M. Metri* Trupti A. Hunnura2 Hanamant B. Sannakki2. "An Approach Of Computer Aided Drug Design (CADD) Tools For In-silico Evaluation Of Various Derivatives Of Antidiabetic Standard Drugs." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 987–97. https://doi.org/10.5281/zenodo.13955358.

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An in-silico ADME/T study utilizing Swiss ADME software was conducted on novel derivatives of standard antidiabetic drugs, revealing reduced toxicity levels compared to existing medications. Docking scores showed significant interactions with antidiabetic and antitubercular properties, successfully binding to protein PDB IDs 8Q0T and 1H5U. Predictive analysis yielded Pa and Pi values (0-1), indicating promising antidiabetic activity. These findings suggest the derivatives' potential for development into enhanced efficacy antidiabetic compounds, opening new avenues for antidiabetic drug discove

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Laware, Ravindra B., Shubhangi P. Pulate, Santosh B. Dighe, and Sanjay B. Bhawar. "Formulation Development and Evaluation of Leaf Extract of Ficus benghalensis for Antidiabetic Activity." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 611–14. http://dx.doi.org/10.22270/jddt.v9i3-s.2919.

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Herbal products are known for their inherent property i.e. comparatively safe and economic. In present study, leaf extract of ficus benghalensis was evaluated for antidiabetic activity. The aim of the research work was to formulate and evaluate capsule dosage form of ethanolic extract. Leaves of Ficus benghalensis collected from local area of Ahmednagar district and shade dried. Ethanolic, Hydroalcoholic and petroleum ether extracts were prepared using soxhlet apparatus. Extracts were screened for antidiabetic activity using alloxan induced diabetes in rats. Oral glucose tolerance test was mea

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Vasanth, Sakthivel, Giridharan Bupesh, Tharumasivam Siva Vijayakumar, Vellingiri Balachandar, and Durai Rajan Gunasekaran. "EVALUATION OF IN VITRO ANTIDIABETIC AND ANTIOXIDANT POTENTIAL OF BARLERIA CRISTATA LEAVES EXTRACTS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 4 (2018): 287. http://dx.doi.org/10.22159/ajpcr.2018.v11i4.24069.

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Objectives: The objectives of the study were to study the in vitro antidiabetic and antioxidant activity of Barleria cristata leaves extracts.Methods: Ethanol extract and petroleum ether extract of leaf and root of B. cristata were tested for their antidiabetic activity. The in vitro antidiabetic activity from α-amylase, α-glucosidase, and antioxidant activity was used to assess the potential activity of the fractions.Results: Our attempt results suggest that ethanol and the petroleum ether leaf extract from B. cristata show signs of dose-dependent increases to inhibitory activity on α-amylase

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Li, Dan-dan, Ying Wang, Eun La Kim, Jongki Hong, and Jee H. Jung. "A New Fungal Triterpene from the Fungus Aspergillus flavus Stimulates Glucose Uptake without Fat Accumulation." Marine Drugs 20, no. 3 (2022): 203. http://dx.doi.org/10.3390/md20030203.

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Through activity-guided fractionation, a new triterpene (asperflagin, 1) was isolated as a PPAR-γ agonist from the jellyfish-derived fungus Aspergillus flavus. Asperflagin displayed selective and moderate transactivation effects on PPAR-γ in Ac2F rat liver cells. Based on further biological evaluation and molecular docking analysis, we postulated that asperflagin might function as a PPAR-γ partial agonist. This compound was calculated to display a typical PPAR-γ ligand–receptor interaction that is distinct from that of full agonistic antidiabetics such as rosiglitazone, and may retain the anti

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Ramesh, Aswathy, Rakesh Kumar Jat, and R. Arunkumar. "Pharmacological Evaluation of Novel 1,3,4-Oxadiazole Derivatives." International Journal of Medical Sciences and Pharma Research 10, no. 1 (2024): 26–34. http://dx.doi.org/10.22270/ijmspr.v10i1.88.

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A series of 2, 5- disubstituted- 1, 3, 4-oxadiazole derivatives (Ox1-Ox10) are synthesized by the ring condensation reaction followed by rearrangement of salicylic acid and phenyl acetic acid with various aromatic acids in presence of phosphorous oxychloride as cyclizing agent. Structure of the new derivatives are confirmed by spectral analysis. Those derivatives having high Pa value in PASS software are subjected to antibacterial, anticancer and antidiabetic studies which yield promising reports. This study helps and stimulate the researcher to exploit the oxadiazole nuclei for the developmen

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Pattan, S. R., P. N, Kasar, B. D. Randale, et al. "SYNTHESIS AND EVALUATION OF SOME NOVEL 1, 3, 4-OXADIAZOLEDERIVATIVES FOR ANTIMICROBIAL AND ANTIDIABETIC ACTIVITIES." INDIAN DRUGS 50, no. 04 (2013): 39–45. http://dx.doi.org/10.53879/id.50.04.p0039.

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A series of 1, 3, 4-Oxadiazole derivatives have been synthesized and evaluated for antimicrobial and antidiabetic activities. The newly synthesized compounds have been characterized by IR, 1 H NMR and elemental analysis. All compounds have shown promising antimicrobial and antidiabetic activities when compared with standard drug ciprofloxacin and acarbose respectively. Compounds A2 ,B2 ,C1 ,D1 ,D2 ,E1 and E2 have shown promising antimicrobial activity while compounds A1 ,A2 ,B1 ,C1 ,D1 ,E1 and E2 have shown promising antidiabetic activity.

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Pattan, S. R., P. N, Kasar, B. D. Randale, et al. "SYNTHESIS AND EVALUATION OF SOME NOVEL 1, 3, 4-OXADIAZOLEDERIVATIVES FOR ANTIMICROBIAL AND ANTIDIABETIC ACTIVITIES." INDIAN DRUGS 50, no. 04 (2013): 39–45. http://dx.doi.org/10.53879/id.50.04.p0039.

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A series of 1, 3, 4-Oxadiazole derivatives have been synthesized and evaluated for antimicrobial and antidiabetic activities. The newly synthesized compounds have been characterized by IR, 1 H NMR and elemental analysis. All compounds have shown promising antimicrobial and antidiabetic activities when compared with standard drug ciprofloxacin and acarbose respectively. Compounds A2 ,B2 ,C1 ,D1 ,D2 ,E1 and E2 have shown promising antimicrobial activity while compounds A1 ,A2 ,B1 ,C1 ,D1 ,E1 and E2 have shown promising antidiabetic activity.

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Presley, Caroline A., Jonathan Chipman, Jea Young Min, et al. "Evaluation of Frailty as an Unmeasured Confounder in Observational Studies of Antidiabetic Medications." Journals of Gerontology: Series A 74, no. 8 (2018): 1282–88. http://dx.doi.org/10.1093/gerona/gly224.

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Abstract Background It is unknown whether observational studies evaluating the association between antidiabetic medications and mortality adequately account for frailty. Our objectives were to evaluate if frailty was a potential confounder in the relationship between antidiabetic medication regimen and mortality and how well administrative and clinical electronic health record (EHR) data account for frailty. Methods We conducted a retrospective cohort study in a single Veterans Health Administration (VHA) healthcare system of 500 hospitalizations—the majority due to heart failure—of Veterans w

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Chavan, Rajashree, Komal Chandhere та Ashok Bhosale. "Design, Synthesis, Biological Evaluation of Tnf-α Inhibi- Tors As Antidiabetic Agents". PDEAS International Journal of Research in Ayurved and Allied Sciences 1, № 1 (2019): 11–17. https://doi.org/10.63778/pdeasijraas-arjcpl/2019_21511.

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The weight loss in obese patients is associated with reduced Tumor necrosis factor-α (TNF-α) production and ameliorated insulin resistance. TNF-α has been shown to be an important mediator of insulin resistance linked to obesity. TNF-α interferes with insulin-signaling by inhibiting tyrosine kinase activity of the insulin receptor and the serine phosphorylation of insulin receptor substrate-1 (IRS-1). Thiazolidinediones serve as a boom in the antidiabetic therapy by increasing the sensitivity of insulin receptors towards insulin. The present study aims at designing novel thiazolidinediones wit

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Pitasari, Nawang Wulan Nago, Tri Murti Andayani, and Tri Wijayanti. "Evaluation of the Use of Antidiabetic Drugs in Patients of Back-Referral Program at the Demak District Pharmacy." JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) 12, no. 2 (2022): 125. http://dx.doi.org/10.22146/jmpf.73841.

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Drugs are one of the important components of the Back-Referral Program (BRP), so the guarantee of the availability of BRP drugs in pharmacies is a factor in the success of BRP implementation. The purpose of this study was to determine the consumption of antidiabetic drugs using ATC/DDD and 90% DU methods, analyze the cost of consuming antidiabetic drugs, and determine the suitability of antidiabetic drugs with the National Formulary. This study was an observational study with a cross-sectional design and retrospective data collection. The study was conducted at 6 BRP pharmacies, namely Pharmac

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M., Prabu, and Kumuthakalavalli R. "ANTIDIABETIC POTENTIAL OF THE OYSTER MUSHROOM PLEUROTUS FLORIDA (MONT.) SINGER." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 51. http://dx.doi.org/10.22159/ijcpr.2017v9i4.20765.

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Objective: The present investigation comprises, in vitro antidiabetic activity such as α-amylase and α-glucosidase inhibitory activities and in vivo antidiabetic activity of methanolic extract of Pleurotus florida.Methods: The fruiting bodies of Pleurotus florida were obtained from Mushroom Unit, Department of Biology, Gandhigram Rural Institute-Deemed University, Gandhigram, Dindigul, Tamil Nadu, India. Sample preparation, qualitative phytochemical analysis, in vitro antidiabetic activities namely α-amylase and α-glucosidase inhibitory activity and in vivo antidiabetic activity namely evaluat

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Kaur, Virender, Kumud Upadhyaya, and Milind Pande. "BIOASSAY-GUIDED EVALUATION OF FICUS SEMICORDATA FOR ANTIDIABETIC ACTIVITY." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 3 (2017): 71. http://dx.doi.org/10.22159/ijpps.2017v9i3.16441.

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Objective: The early stage of diabetes mellitus type 2 is associated with postprandial hyperglycemia. The therapeutic approach involved in the treatment of type 2 diabetes mellitus is the use of agents that can decrease postprandial hyperglycemia by inhibiting carbohydrate digesting enzymes. In an effort of identifying herbal drugs which may become useful in the prevention or mitigation of diabetes, the antidiabetic activity of Ficus semicordata (FS) and its constituents were studied. The present study was undertaken in part to identify the potent antihyperglycemic fraction from the ethanol ex

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Pethe, Mohan M., Anil Rapelliwar, Sushil K. Varma, Pawan Singh, and Umesh B. Telrandhe. "Antidiabetic activity and Safety evaluation of Triticum aestivum (wheatgrass) extract in Alloxan-induced diabetic rats model." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1378–85. http://dx.doi.org/10.25258/ijpqa.15.3.45.

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Triticum aestivum (wheatgrasses) extract was studied for antidiabetic activity using alloxan-induced diabetes mellitus in rats. Triticum aestivum at 50, 100, and 200 mg/kg showed significant antidiabetic activity; it effected profound reductions in blood glucose over 28 days, especially the higher doses of 100 and 200 mg/kg, which were more effective than Glibenclamide. At 2000 mg/kg, the extract did not lower the blood glucose of normoglycemic rats- an indication of its safety and lack of hypoglycemic responses under non-diabetic conditions. It would appear that the antidiabetic activity of T

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Cai, Kaida, Zhe Zhang, Wenzhou Zhu, Xiangwei Liu, Tingqing Yu, and Wang Liao. "Predicting Antidiabetic Peptide Activity: A Machine Learning Perspective on Type 1 and Type 2 Diabetes." International Journal of Molecular Sciences 25, no. 18 (2024): 10020. http://dx.doi.org/10.3390/ijms251810020.

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Diabetes mellitus (DM) presents a critical global health challenge, characterized by persistent hyperglycemia and associated with substantial economic and health-related burdens. This study employs advanced machine-learning techniques to improve the prediction and classification of antidiabetic peptides, with a particular focus on differentiating those effective against T1DM from those targeting T2DM. We integrate feature selection with analysis methods, including logistic regression, support vector machines (SVM), and adaptive boosting (AdaBoost), to classify antidiabetic peptides based on ke

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Singh, Sristi, and Yogendra Mavai. "Evaluation of comparative antidiabetic efficacy of cow urine, A2 milk, wheatgrass juice and antidiabetic agent." Asian Journal of Pharmacy and Pharmacology 4, no. 3 (2018): 358–63. http://dx.doi.org/10.31024/ajpp.2018.4.3.19.

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Liaquat, Iqra, Arif-ullah Khan, and Salman Khan. "Pharmacological evaluation of continentalic acid for antidiabetic potential." Biomedicine & Pharmacotherapy 138 (June 2021): 111411. http://dx.doi.org/10.1016/j.biopha.2021.111411.

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Gnananath, Kattamanchi, Kontham Ramakanth Reddy, Gudur Pavan Kumar, Bheemanapally Krishna, Karka Srinivas Reddy, and Avvari Sanjeeva Kumar. "Evaluation of antidiabetic activity in Corallocarpus epigaeus rhizomes." International Current Pharmaceutical Journal 2, no. 3 (2013): 53–56. http://dx.doi.org/10.3329/icpj.v2i3.13581.

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From these results it can be understood that plant extract showing its pharmacological action on diabetes between the time intervals of 1-2 hr after its administration. This is exactly what the action that is being observed from the standard Glibenclamide group which also shown its action at its 1-2 hr of administration to the animals. Here the statistically significant action of the higher dose of plant extract can be compared with that of the standard Glibenclamide group. From these results it can be understood that the plant extract is capable of inhibiting the elevation of blood glucose le

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Ablat, Abdulwali, Jamaludin Mohamad, Khalijah Awang, Jamil A. Shilpi, and Aditya Arya. "Evaluation of Antidiabetic and Antioxidant Properties ofBrucea javanicaSeed." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/786130.

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The ethanol extract ofB. javanicaseed was fractionated with solvents of different polarities and tested for antioxidant activities by several assays including DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP), ferrous ion chelating activity (FCA), and nitric oxide radical scavenging activity (NORSA) along with their polyphenolic contents. Antidiabetic activity was evaluated both in vitro and in vivo using a glycogen phosphorylaseα(GPα) inhibition assay and oral glucose tolerance test (OGTT) in nondiabetic rats. The ethyl acetate fraction (EAF), rich in tannin, exhibite

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MARIAPPAN, G., B. P. SAHA, SRIPARNA DATTA, DEEPAK KUMAR, and P. K. HALDAR. "Design, synthesis and antidiabetic evaluation of oxazolone derivatives." Journal of Chemical Sciences 123, no. 3 (2011): 335–41. http://dx.doi.org/10.1007/s12039-011-0079-2.

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Bais, SK, NS Dhavre, and Diptee Devmare. "Formulations and evaluation of antidiabetic Tinospora cordifolia powder." International Journal of Pharmacognosy and Life Science 5, no. 1 (2023): 09–16. http://dx.doi.org/10.33545/27072827.2023.v5.i1a.103.

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Shahzad, Naiyer. "Monitoring of adverse drug reactions in individuals with type 2 diabetes mellitus receiving oral hypoglycemic agents." Journal of Umm Al-Qura University for Medical Sciences 9, no. 1 (2023): 37–44. http://dx.doi.org/10.54940/ms84792341.

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Background: This study intends to ascertain the prevalence and overall burden of various adverse drug reactions (ADRs) driven by oral antidiabetics for treating type II diabetes mellitus (T2DM) in India. Methods: Patients with T2DM taking oral antidiabetic medications participated in prospective observational research. Data collection used the pretested format by the Indian pharmacovigilance program to record the history of drugs suspected to be responsible for ADRs. The causality evaluation is according to the guidelines of the Uppsala Monitoring Center and the World Health Organization. Resu

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P, Geetha, and Shanmugasundharam P. "DRUG UTILIZATION EVALUATION OF ANTIDIABETIC DRUGS AMONG TYPE 2 DIABETES PATIENTS OF TAMIL NADU." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 202. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.19342.

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Objectives: The aim of the study was to assess the prescribing pattern of antidiabetic drugs in Type 2 diabetes outpatients visiting to Diabetes Centre, Chennai.Methods: A prospective study was carried out by evaluating 115 prescriptions of antidiabetic drugs over the period of 4 months to assess the prescribing pattern of antidiabetic drugs and also drugs used for other complications of Type 2 DM.Results: Totally, 115 patients were evaluated, 58 were of male and 57 were of female. An average number of drugs per encounter were found to be 4.47. An average number of antidiabetic drugs were foun

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M, Vani, Vasavi T, and Uma Maheswari Devi P. "EVALUATION OF IN VITRO ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF SEAGRASS HALOPHILA BECCARII." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 150. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.25752.

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Objectives: The objectives of this study were to analyze the in vitro antidiabetic activity of methanolic extract of seagrass.Methods: The methanolic extract of Halophila beccarii was tested for its in vitro antidiabetic potential through inhibition of carbohydrate digestive enzymes such as α- amylase and α-glucosidase, glucose diffusion assay, glucose adsorption capacity, and enhancement of glucose uptake activity in yeast cells.Results: The crude extract of H. beccarii showed strong inhibition of ɑ-amylase and ɑ-glucosidase as on comparison with the standard enzyme inhibitor acarbose. The an

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Rudi Kartika, Bohari, Subur P. Pasaribu, Aman Sentosa Panggabean, Daniel, and Dirgarini Julia Nurlianti. "Evaluation of blood glucose lowering activity of Coffea robusta leaf extract in mice induced by alloxan." GSC Biological and Pharmaceutical Sciences 31, no. 2 (2025): 017–21. https://doi.org/10.30574/gscbps.2025.31.2.0119.

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An investigation of the antidiabetic activity of coffee leaf (Coffearobusta) extract in ethanol with doses 13,95, 27,9 and 55,8 mg/kg BW given orally to white male mice. Measurement of the blood glucose level was done day to-0, 8 and 18 using glucometer and glucotest strip. Doses variation of the ethanol extract coffee leaf showed that the dose of 27,9 mg/kg BW gave the best antidiabetic activity 59,61%. This experiment showed gave the best antidiabetic activity result gift ethanol extract coffee leaf. And Phytochemical screening ofthe ethanol extract coffee leaf showed the presence of alkaloi

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K., Ahmed S., Chakrapani Cheekavolu, Naveen Alasyam, and Sunil M. "Evaluation of antidiabetic potential of hydroalcoholic extract of Annona squamosa (HAEAS) leaf in alloxan monohydrate induced diabetic Albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 179. http://dx.doi.org/10.18203/2319-2003.ijbcp20175696.

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Background: Diabetes is almost growing health concern worldwide and now emerging as an epidemic world over. Recently, full attention is being paid to the study of natural products as potential antidiabetics. Objective of the study was to evaluate the antidiabetic effect of hydroalcoholic leaf extract of Annona squamosa (HAEAS) plant in alloxan monohydrate induced diabetic albino rats.Methods: Almost a 30 Albino rats with 150- 200 grams weight were weighed and grouped into 5 equal groups taking 6 rats in every group. Group A served as normal control, Group B as diabetic control, received alloxa

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Usman, Usman, Pintaka Kusumaningtyas, Sukemi Sukemi, and Erwin Erwin. "An Evaluation of the Antidiabetic and Antimicrobial Activity of an Ethanolic Extract from Rhizophora mucronata Leaf." Jurnal Sains dan Kesehatan 5, no. 4 (2023): 541–49. http://dx.doi.org/10.25026/jsk.v5i4.1978.

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The aim of this research was to determine the antidiabetic and antimicrobial properties of ethanolic extract of Rhizophora mucronata leaves, as well as the phytochemical elements contained in the leaf extract. Extracts from R. mucronata leaf samples were obtained by maceration in ethanol-based solvents. The ethanolic extract of R. mucronata leaves is known to have an antidiabetic effect on mice, evidenced by its ability to reduce blood glucose levels. Giving ethanol extract at a dose of 600 mg/kg BW gives the greatest antidiabetic effect. The antibacterial activity of the extract against the t

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Mathusalini, Sadasivam, Thangaraj Arasakumar, Krishnasamy Lakshmi, et al. "Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores." New Journal of Chemistry 40, no. 6 (2016): 5164–69. http://dx.doi.org/10.1039/c6nj00534a.

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Aini, Qurrota, Madyawati Latief, Indra Lasmana Tarigan, and Masruri MASRURI. "Phytochemistry and Antidiabetic Evaluation in-vitro and in-vivo of Ethyl Acetate Fractions from Sungkai Leaves (Peronema canescens Jack)." Journal of Pure and Applied Chemistry Research 13, no. 2 (2024): 127–36. http://dx.doi.org/10.21776/ub.jpacr.2024.013.02.700.

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The paper reports the in vivo and in vitro antidiabetic activity of bioactive compounds composed of ethyl acetate fractions from Sungkai (Peronema canescens Jack). The fractions are obtained from vacuum liquid chromatography (F1, F2 and F3). Phytochemicals screening, UV-Vis and FTIR spectrometry analysis is applied to detect secondary metabolite composed of the fractions. In addition, in vitro antidiabetic capability is measured inhibiting a-amylase activity, and in vivo evaluation is conducted using diabetic rat's model induced by alloxan. It was found that fraction collected as a white preci

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Zhang, Dongdong, Karuppusamy Arunachalam, Yuehu Wang, et al. "Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar." Scientific World Journal 2021 (August 26, 2021): 1–10. http://dx.doi.org/10.1155/2021/1424675.

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Objectives. To explore the effective and safe medicines for treating diabetes. Methods. Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. Results. The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison r

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Khan, Yousaf, Aneela Maalik, Wajid Rehman, et al. "Synthesis, in vitro bio-evaluation and in silico molecular docking studies of thiadiazole-based Schiff base derivatives." Future Medicinal Chemistry 16, no. 4 (2024): 335–48. http://dx.doi.org/10.4155/fmc-2023-0276.

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Aim: Recently, thiadiazole-containing drugs have gained greater clinical relevance and are being explored for the development of new antidiabetic, antiurease and antimicrobial agents that target drug resistance. Methods & results: The authors disclose the synthesis of N-(5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl)methanimine derivatives starting from 4-(trifluoromethyl)benzoic acid. All of the synthesized derivatives were evaluated for their biological potential in order to investigate the inhibitory activity against antidiabetic, antiurease and antibacterial profiles. Compounds 1

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N.D. Kandpal, A. Tamta, A. Bhoj, K. Tamta, J. Prasad, and B. Chandra. "EVALUATION OF THE BIOMEDICAL APPLICATIONS OF NiO NANOPARTICLES SYNTHESIZED WITH COW MILK AND AQUEOUS ETHYLENE GLYCOL." RASAYAN Journal of Chemistry 18, no. 02 (2025): 1042–48. https://doi.org/10.31788/rjc.2025.1829136.

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NiO-NPs were prepared using cow milk (CM) and 30% ethylene glycol (EG). The production of NiO-NPs was indicated through a color transformation in the solution mixture from yellow to black. To evaluate the effectiveness of NiO-NPs as anti-inflammatory and antidiabetic agents. The in vitro antimicrobial activity tests were carried out through diffusion in agar agar against microorganisms at different concentrations of the sample. Our results in terms of IC50 indicate that the mean value was 14.95±0.02 and 11.89±0.06 for antidiabetic activity and anti-inflammatory activity, respectively. The stud

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Shukla, Abha, and Anchal Choudhary. "EVALUATION OF IN VITRO ANTIDIABETIC AND ANTI-INFLAMMATORY ACTIVITIES OF LEAVES EXTRACT OF BOEHMERIA RUGULOSA." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (2018): 200. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.25906.

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Objective: The objective of the study is to evaluate in vitro antidiabetic and anti-inflammatory activity of different extracts of leaves of Boehmeria rugulosa by different methods.Methods: In vitro α-glucose and α-amylase were used for antidiabetic activity and lipoxygenase, and protein denaturation method of inhibition assays was used to measure anti-inflammatory activity. Successive extraction of leaves petroleum ether (PE), chloroform (CH), ethyl acetate (EA), acetone (AC), and ethanol (ETH) was performed, and extracts obtained from the extraction were applicable to these activities.Result

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Akhtar, Naheed, Muhammad Akram, Muhammad Daniyal, and Saeed Ahmad. "Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats." International Journal of Immunopathology and Pharmacology 32 (January 2018): 205873841881467. http://dx.doi.org/10.1177/2058738418814678.

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Different allopathic drugs are being used for the treatment of diabetes mellitus but more emphasis are being placed on the use of medicinal plants, herbs, and natural extracts of fruits and vegetables due to their easy availability, easy consummation with low cost, and with no well-reported side effects. White skinned sweet potato (WSSP; Ipomoea batatas L.) peel-off was selected to find out its antidiabetic potential as well as to explore the effects on selected biochemical parameters in diabetes-induced Wistar rats. In young (3–4 months) and old (up to 1 year) diabetic Wistar rats, it was fou

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Zahan, Ronok, Laizuman Nahar, Zahangir Alam, Mst Luthfun Nesa, and M. Ekramul Haque. "Evaluation of Antidiarheal and Antidiabetic Activities of Wrigthia arborea (Dennst.) Mabb." Bangladesh Pharmaceutical Journal 16, no. 2 (2015): 211–16. http://dx.doi.org/10.3329/bpj.v16i2.22306.

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Wrigthia arborea (Dennst.) Mabb., locally known as Shet-kurchi, is a small deciduous tree. These species are important in the traditional healthcare, especially in menstrual and renal complaints. The present study was designed to investigate the antidiarheal and antidiabetic activities of methanol extract of W. arborea. The methanol extract was studied for antidiarrhoeal properties using castor oil and magnesium sulphate induced diarrhoeal model in mice. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the stud

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Duc, Chong Kim Thien, Duy Toan Pham, Huynh Bich Lieu Nguyen, and Chi Linh Tran. "Evaluation of Phytochemical Screening, ‘Antibacterial, Antioxidant, Anti-Inflammatory, and Antidiabetic Activities’ of Sequentially Extracted Ixora Duffii Leaves Extract." Trends in Sciences 22, no. 7 (2025): 10028. https://doi.org/10.48048/tis.2025.10028.

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Identifying its bioactive compounds is essential for understanding its therapeutic potential. The increasing prevalence of antibiotic resistance, inflammation-related diseases, and diabetes underscores the need for effective natural alternatives. Ixora duffii, a medicinal plant from the Rubiaceae family commonly used in traditional Vietnamese medicine, has not been evaluated its biological activities. Therefore, this study was conducted to investigate the antibacterial, antioxidant, anti-inflammatory, and antidiabetic activity of the ethanol, n-hexane, dichloromethane, ethyl acetate, and water

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Ifebi, H. M. N., F. A. Onyegbule, C. C. Ezea, S. O. Ifenatuora, and F. C. Anowi. "Evaluation of Antidiabetic Property of Sansevieria liberica Gerald and Labroy (Dracaenaceae) Leaf Using Alloxan Induced Diabetes Model." Nigerian Journal of Pharmaceutical Research 16, no. 2 (2021): 73–84. http://dx.doi.org/10.4314/njpr.v16i2.9s.

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Background: The phytochemical screening and antidiabetic activities of the methanol leaf extract and fractions of Sansevieria liberica Ger. and Labr. were investigated.Objectives: To identify the phytoconstituents present and evaluate the anti-diabetic activity of the leaf of S. liberica Ger. and Labr.Material and Methods: A 1.2 g of the pulverized leaf was cold macerated in methanol to obtain 240 g of the crude extract (CE), fractionation was done using n-hexane, ethylacetate and butanol. The CE and the fractions were screened for phytochemical and antidiabetic analysis using standard procedu

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Sivakumar, G., R. Sathish Kumar, P. Aruna, and Laksmana Perumal. "Antioxidant, Antimicrobial and Antidiabetic activities of Insulin plant rhizome extracts - A comparative study." Indian Journal of Pharmacy and Pharmacology 10, no. 2 (2023): 116–21. http://dx.doi.org/10.18231/j.ijpp.2023.024.

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retained the name as Insulin plant through traditional practice, further phytochemical and pharmacological evaluation of leaves of the plant has proven record on wider therapeutic potential such as antioxidant, antimicrobial and antidiabetic activity. Our interest of current research is to explore the rhizome by multiple extraction and to screen and find out the specific therapeutic potential of the specific extracts through relevant phytochemical and pharmacological evaluation. DPPH, Disc Diffusion and DNS methods were chosen to evaluate antioxidant and antibacterial and antidiabetic activity

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