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1

Brandt, Erik G. "Interactions and dynamics in biophysical model systems /." Stockholm : Skolan för teknikvetenskap, Kungliga Tekniska högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-10300.

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2

Elmlund, Hans. "Protein structure dynamics and interplay : by single-particle electron microscopy." Doctoral thesis, Stockholm : Teknik och hälsa, Technology and Health, Kungliga Tekniska högskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4669.

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3

Dale, Michael Anthony Joseph. "Global Energy Modelling : A Biophysical Approach (GEMBA)." Thesis, University of Canterbury. Mechanical Engineering, 2010. http://hdl.handle.net/10092/5156.

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The aim of this thesis is to take a broad conceptual overview of the global energy system and investigate what the aims of sustainability might entail for such a system. The work presented uses a biophysical economic approach in that the dynamics of the global economy are investigated using the tool box of the physical sciences, including the laws of thermodynamics and the methods of energy analysis. Modern society currently uses approximately 500 exajoules (EJ = 10^18 J) of total primary energy supply (TPES) each year. This energy consumption has been increasing at roughly 2% per
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4

Pearson, Joshua Thomas. "A biophysical study of protein dynamics and protein-ligand interactions /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8173.

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5

Stollar, Elliott Jonathan. "Biophysical and crystallographic investigation of homeodomain stability, dynamics, and recognition." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615778.

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6

Zerlaut, Yann. "Biophysical and circuit properties underlying population dynamics in neocortical networks." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066095/document.

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Le néocortex possède un état activé dans lequel l'activité corticalemanifeste un comportement complexe. Au niveau cellulaire, l'activitéest caractérisée par de fortes fluctuations sous-liminaires dupotential membranaire et une décharge irrégulière à bassefréquence. Au niveau du réseau, l'activité est marquée par un faibleniveau de synchronie et une dynamique chaotique. Néanmoins, c'est dansce régime que l'information est traitée de manière fiable par lesréseaux neuronaux. Ce régime est donc crucial pour le traitement del'information par le cortex. Dans cette thèse, nous contribuons à sacompréh
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7

Doerdelmann, Thomas. "Structural and Biophysical Studies of the Pitx2 Homeodomain." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307443112.

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8

Pathmasiri, Wimal. "Structural and Biophysical Studies of Nucleic Acids." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8245.

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9

Reyns, Nathalie Brigitte. "Biophysical dispersal dynamics of the blue crab in Pamlico Sound, North Carolina." NCSU, 2004. http://www.lib.ncsu.edu/theses/available/etd-10312004-143755/.

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For many species such as the blue crab, Callinectes sapidus, successful estuarine recruitment to juvenile nursery habitats is dependent on the biophysical processes experienced during dispersal of the early life stages. The goal of this study was to determine how blue crab primary (postlarval) and secondary (early juvenile) dispersal occurs within a predominately wind-driven estuary, Pamlico Sound, North Carolina, USA. We (1) characterized circulation patterns in Pamlico Sound during the fall blue crab recruitment months over two consecutive years using current meters (2) sampled during multip
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10

Chimatiro, Sloans Kalumba. "The biophysical dynamics of the Lower Shire River Floodplain fisheries in Malawi /." Connect to this title online, 2004. http://eprints.ru.ac.za/177/.

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11

Rohr, Tyler W. "Computational analysis of the biophysical controls on Southern Ocean phytoplankton ecosystem dynamics." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122325.

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Thesis: Ph. D., Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Department of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 193-220).<br>Southern Ocean net community productivity plays an out sized role in regulating global biogeochemical cycling and climate dynamics. The structure of spatial-temporal variability in phytoplankton ecosystem dynamics is largely governed by physical processes but a vari
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12

Leekumjorn, Sukit. "Molecular Dynamics Simulations for the Study of Biophysical Processes on Biological Membranes." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/29180.

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Phospholipid bilayers constitute the primary structural element of biological membranes, and as such, they play a central role in biochemical and biophysical processes at the cellular level, including cell protection, intercellular interactions, trans-membrane transport, cell morphology, and protein function, to name a few. The properties of phospholipid bilayers are thus of great interest from both experimental and theoretical standpoints. Although experiments have provided much of the macroscopic functions and properties of biological membranes, insight into specific mechanisms at the mole
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13

Chimatiro, Sloans Kalumba. "The biophysical dynamics of the Lower Shire River Floodplain fisheries in Malawi." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1005086.

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Fishes of African floodplains typically comprise populations having short life cycles, relatively few age groups, more generalised feeding behaviour, and which experience spawning success that is strongly influenced by abiotic factors such as hydrological regime of the river, climatic seasonality and habitat characteristics. In addition, African river-floodplain ecosystems do not have appropriate predictive models for estimating yield in these ecosystems. While most predictive models developed to date for floodplain fisheries have taken into account morpho-edaphic factors, they have generally
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14

Wadhwa, Vibhuti. "Biophysical approaches towards greater understanding of eukaryotic zinc sensing." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1593621283583113.

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15

Herrera-Valdez, Marco Arieli. "Geometry and nonlinear dynamics underlying excitability phenotypes in biophysical models of membrane potential." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/312741.

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The main goal of this dissertation was to study the bifurcation structure underlying families of low dimensional dynamical systems that model cellular excitability. One of the main contributions of this work is a mathematical characterization of profiles of electrophysiological activity in excitable cells of the same identified type, and across cell types, as a function of the relative levels of expression of ion channels coded by specific genes. In doing so, a generic formulation for transmembrane transport was derived from first principles in two different ways, expanding previous work by o
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16

Piechnik, Stefan K. "A mathematical and biophysical modelling of cerebral blood flow and cerebrospinal fluid dynamics." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269226.

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17

Bansept, Florence. "Biophysical modeling of bacterial population dynamics and the immune response in the gut." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS397.

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La première partie de cette thèse porte sur les dynamiques de colonisation d'une population bactérienne au début d'une infection intestinale. Le but est de déduire des paramètres biologiquement pertinents de données indirectes. Un modèle simple est étudié, et l'on discute de l'observable optimale pour caractériser la variabilité d'une distribution d'étiquettes génétiques. Des arguments biologiques et des incohérences entre des observables expérimentales avec le premier modèle motivent l'étude d'un second, où deux sous-populations se répliquent à des taux différents, mais on ne peut pas conclur
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18

Rahmati, Vahid, Knut Kirmse, Dimitrije Marković, Knut Holthoff, and Stefan J. Kiebel. "Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-203385.

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Calcium imaging has been used as a promising technique to monitor the dynamic activity of neuronal populations. However, the calcium trace is temporally smeared which restricts the extraction of quantities of interest such as spike trains of individual neurons. To address this issue, spike reconstruction algorithms have been introduced. One limitation of such reconstructions is that the underlying models are not informed about the biophysics of spike and burst generations. Such existing prior knowledge might be useful for constraining the possible solutions of spikes. Here we describe, in a no
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19

Jackson, Beckford Shirlene R. "Biophysical Characterization of the Binding of Homologous Anthraquinone Amides to DNA." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/chemistry_diss/70.

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The synthesis of four homologous anthraquinones (AQ I-IV) bearing increasing lengths of polyethylene glycol (PEG) side chains and their binding to AT- and GC-rich DNA hairpins are reported. The molecules were designed such that the cationic charge is at a constant position and the ethylene glycol units chosen to allow significant increases in size with minimal changes in hydrophobicity. The mode and affinity of binding were assessed using circular dichroism (CD), nuclear magnetic resonance (NMR), surface plasmon resonance (SPR), and isothermal titration calorimetry (ITC). The binding affinity
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20

Talathi, Sachin S. "Biophysical modelling of synaptic plasticity and its function in the dynamics of neuronal networks." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3214710.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed July 10, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 147-155).
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21

Ibrahim, Moustafa Ismaiel Omar. "Biophysical studies of the structure and backbone dynamics of gsPGK using NMR relaxation methods." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543234.

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22

Ni, Haibo. "Biophysical modelling of functional impacts of potassium channel mutations on human atrial and ventricular dynamics." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/biophysical-modelling-of-functional-impacts-of-potassium-channel-mutations-on-human-atrial-and-ventricular-dynamics(3372fd6a-850b-4f7d-893a-e2da28269ba8).html.

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Atrial fibrillation (AF) is the most common cardiac arrhythmia causing morbidity and mortality. Despite recent advances, developing effective and safe anti-AF pharmaceutical therapies remains challenging and is prone to adverse effects in the ventricles. Atrial-selective therapies are promising in managing AF. A better understanding of the role of the atrial-specific ion channels in the atrial arrhythmogenesis and contractility, as well as the anti-AF effects of blocking these channels is of interests. Also, a 3D ventricle-torso model capable of modelling ventricular electrical activities and
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23

Ådén, Jörgen. "NMR studies of protein dynamics and structure." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36790.

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Enzymes are extraordinary molecules that can accelerate chemical reactions by several orders of magnitude. With recent advancements in structural biology together with classical enzymology the mechanism of many enzymes has become understood at the molecular level. During the last ten years significant efforts have been invested to understand the structure and dynamics of the actual catalyst (i. e. the enzyme). There has been a tremendous development in NMR spectroscopy (both hardware and pulse programs) that have enabled detailed studies of protein dynamics. In many cases there exists a strong
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24

Streichan, Sebastian J. [Verfasser], and Karsten [Akademischer Betreuer] Kruse. "On biophysical aspects of growth and dynamics of epithelial tissues / Sebastian J. Streichan. Betreuer: Karsten Kruse." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051434068/34.

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25

Wild, Karen Ann. "The dynamics of the deep chlorophyll maximum in the vicinity of the Canary Islands (Spain)." Thesis, Bangor University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481740.

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26

Gustafsson, Robert. "Biophysical characterization of the *5 protein variant of human thiopurine methyltransferase by NMR spectroscopy." Thesis, Linköpings universitet, Molekylär Bioteknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-78526.

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Human thiopurine methyltransferase (TPMT) is an enzyme involved in the metabolism of thiopurine drugs, which are widely used in leukemia and inflammatory bowel diseases such as ulcerative colitis and Crohn´s disease. Due to genetic polymorphisms, approximately 30 protein variants are present in the population, some of which have significantly lowered activity. TPMT *5 (Leu49Ser) is one of the protein variants with almost no activity. The mutation is positioned in the hydrophobic core of the protein, close to the active site. Hydrogen exchange rates measured with NMR spectroscopy for N-terminal
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27

Piekielek, Nathan Brian. "Remote sensing grassland phenology in the greater Yellowstone ecosystem: biophysical correlates, land use effects and patch dynamics." Diss., Montana State University, 2012. http://etd.lib.montana.edu/etd/2012/piekielek/PiekielekN0812.pdf.

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Vegetation phenology refers to the seasonal timing of repeat biological events such as bud burst and primary-productivity and their relationship to climate. The spatial location and timing of phenology is relevant to a wide-variety of questions in ecology including the space use and population dynamics of migratory herbivores. Recent technological (remote sensing) and methodological (statistical smoothing algorithms and weighted-regression) advancement now allow for mapping spatial and temporal patterns of vegetation phenology across large spatial extents and at fine-temporal scales. It also a
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28

Khanna, Neha, and Neha Khanna@mdbc gov au. "Investigation of phytoplankton dynamics using time-series analysis of biophysical parameters in Gippsland Lakes, South-eastern Australia." RMIT University. Civil, Environmental and Chemical Engineering, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080226.123435.

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There is a need for ecological modelling to help understand the dynamics in ecological systems, and thus aid management decisions to maintain or improve the quality of the ecological systems. This research focuses on non linear statistical modelling of observations from an estuarine system, Gippsland Lakes, on the south-eastern coast of Australia. Feed forward neural networks are used to model chlorophyll time series from a fixed monitoring station at Point King. The research proposes a systematic approach to modelling in ecology using feed forward neural networks, to ensure: (a) that res
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29

Tory, Monica C. "Colicin E1 channel peptide-membrane interactions, a biophysical approach to the molecular state, binding, and solvent dynamics." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq24512.pdf.

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30

GRAÇA, André. "Biophysical analysis of PS II – LHCII supercomplex : Understanding the LHCII phosphorylation-dependent dynamics along the thylakoid membrane." Thesis, Umeå universitet, Kemiska institutionen, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149091.

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31

Bellaiche, Mathias Moussine Jacques. "Molecular mechanisms of protein self-assembly and aggregation." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277621.

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In this thesis, we investigate the mechanisms driving the self-assembly of peptides and proteins using computational and theoretical tools, always validating our results with experimental measures when possible. In the first part, Chapters 2-5, we focus on the Aβ system, a peptide whose aggregation is intimately linked with the development of Alzheimer's Disease. We begin by simulating the major alloforms of the peptide, Aβ_40 and Aβ_42, demonstrating that the two populate similar disordered ensembles and matching experimental data. Next we investigate how disordered Aβ_42 monomers interact wi
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32

Dean, Cayla Whitney. "Biophysical Interactions in the Straits of Florida: Turbulent Mixing Due to Diel Vertical Migrations of Zooplankton." NSUWorks, 2014. http://nsuworks.nova.edu/occ_stuetd/14.

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Diel vertical migrations (DVM) comprise the largest animal migration on the planet and are a phenomenon present in all bodies of water on Earth. A strong sound scattering layer undergoing DVM was observed in the Straits of Florida via a bottom-mounted Acoustic Doppler current profiler (ADCP) Workhorse Longranger 75 kHz (Teledyne RD Instruments) located at the 244 m isobath. ADCP average backscatter showed a clear periodicity corresponding with sunrise and sunset times indicating the presence of a nocturnal DVM. Analysis of the ADCP backscatter data indicated zooplankton swimming velocities wer
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33

Reverey, Julia Franziska [Verfasser]. "Biophysical Studies of Processes Involved in Acanthamoeba Infections : Contact Lens Contamination, Adhesion, and Intracellular Dynamics / Julia Franziska Reverey." Kiel : Universitätsbibliothek Kiel, 2014. http://d-nb.info/1050388682/34.

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34

Stelzl, Lukas Sebastian. "Studying marcomolecular transitions by NMR and computer simulations." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:6e4bbe06-fc58-471b-a932-d940fe78b9a5.

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Macromolecular transitions such as conformational changes and protein-protein association underlie many biological processes. Conformational changes in the N-terminal domain of the transmembrane protein DsbD (nDsbD) were studied by NMR and molecular dynamics (MD) simulations. nDsbD supplies reductant to biosynthetic pathways in the oxidising periplasm of Gram-negative bacteria after receiving reductant from the C-terminal domain of DsbD (cDsbD). Reductant transfer in the DsbD pathway happens via protein-protein association and subsequent thiol-disulphide exchange reactions. The cap loop shield
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35

Sukumaran, Madhav. "Biophysical investigations of AMPA receptor N-terminal domain structure and function reveal mechanisms underlying receptor assembly, dynamics, and allosteric potential." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708278.

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36

Verspecht, Florence. "Temporal dynamics of the coastal water column." University of Western Australia. School of Environmental Systems Engineering, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0097.

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Field measurements and numerical modelling of the shallow coastal waters offshore in south-western Australia were used to describe changes in the water column's vertical structure and the biological response on temporal scales of the order of hours and days. A cycle of chlorophyll a concentration, primary production, and photosystem II function on a diel timescale, which was related to changes in the solar irradiance and thermal structure, was identified. The diel cycle included (1) vertically well-mixed (or weakly linear) conditions in density and chlorophyll a early in the morning, resulting
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37

Dutagaci, Bercem [Verfasser], Clemens [Akademischer Betreuer] Glaubitz, and Peter [Akademischer Betreuer] Güntert. "Biophysical Studies of Lipid Membranes by Solid State NMR and Molecular Dynamics Simulations / Bercem Dutagaci. Gutachter: Clemens Glaubitz ; Peter Güntert. Betreuer: Clemens Glaubitz." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2013. http://d-nb.info/1044772786/34.

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38

Denk, Jonas [Verfasser], and Erwin [Akademischer Betreuer] Frey. "Collective behavior in biophysical systems : from patterns in non-equilibrium protein systems to growth dynamics of cell populations / Jonas Denk ; Betreuer: Erwin Frey." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1220631779/34.

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39

Hogben, Hannah J. "Coherent spin dynamics of radical pairs in weak magnetic fields." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:61c4ab7e-406f-4193-949a-b5a70f43e3e1.

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The outcome of chemical reactions proceeding via radical pair (RP) intermediates can be influenced by the magnitude and direction of applied magnetic fields, even for interaction strengths far smaller than the thermal energy. Sensitivity to Earth-strength magnetic fields has been suggested as a biophysical mechanism of animal magnetoreception and this thesis is concerned with simulations of the effects of such weak magnetic fields on RP reaction yields. State-space restriction techniques previously used in the simulation of NMR spectra are here applied to RPs. Methods for improving the efficie
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40

Babi, Almenar Javier. "Characterisation, biophysical modelling and monetary valuation of urban nature-based solutions as a support tool for urban planning and landscape design." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/288810.

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The recognition of nature in the resolution of societal challenges has been growing in relevance. This recognition has been associated with the development of new concepts from science and policy such as natural capital, ecosystem services, green infrastructure, and more recently Nature-Based Solutions (NBS). NBS intends to address societal challenges in an effective and adaptive form providing economic, social, and environmental benefits. The overall aim of this PhD thesis is to develop an environmental and economic assessment of NBS for highly urbanised territories based on rationales and mo
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41

Zietz, Burkhard. "An Ultrafast Spectroscopic and Quantum-Chemical Study of the Photochemistry of Bilirubin : Initial Processes in the Phototherapy for Neonatal Jaundice." Doctoral thesis, Umeå : Dept. of Chemistry, Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-672.

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42

Shen, Tongye. "Fluctuations and stochastic dynamics in molecular biophysics /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3061634.

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43

Klingelhoefer, Jochen W. "Biophysics of nanopores-multiscale molecular dynamics simulation studies." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540136.

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44

Harrison, Ryan M. "Molecular biophysics of strong DNA bending and the RecQ DNA helicase." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f02fc167-b705-4275-a413-21d13b5d94c3.

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Molecular biophysics is a rapidly evolving field aimed at the physics-based investigation of the biomolecular processes that enable life. In this thesis, we explore two such processes: the thermodynamics of DNA bending, and the mechanism of the RecQ DNA helicase. A computational approach using a coarse-grained model of DNA is employed for the former; an experimental approach relying heavily on single-molecule fluorescence for the latter. There is much interest in understanding the physics of DNA bending, due to both its biological role in genome regulation and its relevance to nanotechnology.
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45

Brown, Peter N. "Biophysical and structural characterisation of protein-peptide interactions." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/3982.

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Proliferating cell nuclear antigen (PCNA) is an essential protein in the cell. It is involved in transcription and many types of DNA repair and replication. Homologues of this protein are found in all orders of life. The high level of conservation and essential nature of PCNA infers that it may be a potential drug target for anti-caner drugs in humans and also a potential anti-parasitic target. X-ray structures of PCNA from Homo sapiens (Hs), Schizosaccharomyces pombe (Sp) and Leishmania major (Lm) are now available and can be used as a template for structure based drug design. In this work PC
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46

Morris, Eliza. "Mechanics and Dynamics of Biopolymer Networks." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11647.

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The three major mechanical components of cells are the biopolymers actin, microtubules, and intermediate filaments. Cellular processes are all highly reliant on the mechanics of the specific biopolymers and the networks they form, rendering necessary the study of both the kinetics and mechanics of the cytoskeletal components. Here, we study the in vitro mechanics of actin and composite actin/vimentin networks, and the effect of various actin-binding proteins on these networks.<br>Engineering and Applied Sciences
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47

Worster, Katy Lynn. "Coordination dynamics of walking." Thesis, University of Colorado at Denver, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3702117.

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<p> Although coordination has been identified as a fundamental element necessary for the successful achievement of walking, this aspect of gait has yet to be embraced into instrumented gait analysis, perhaps in part due to the lack of a normative reference and unfamiliarity of mathematical methods that are best suited to capture this essential behavior. Therefore, this work focused on expanding clinical gait analysis techniques by validating nonlinear methods that describe the influence of neurological control on the musculoskeletal system. This body of work investigated the coordination dynam
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48

Borek, Bartlomiej. "Dynamics of heterogeneous excitable media with pacemakers." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107795.

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The heart is a heterogeneous excitable tissue embedded with pacemakers. To understand the fundamental rules governing its behaviour it is useful to investigate the interplay between structure and dynamics in simplified experimental and mathematical models. This thesis examines FitzHugh-Nagumo type reaction-diffusion equation models motivated by experiments with engineered cardiac tissue culture. The aim is to relate how the design properties of these systems determine the underlying spatiotemporal dynamics. First, a functional relation between randomly distributed heterogeneities and conductio
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49

Leftin, Avigdor. "Nuclear magnetic resonance probes of membrane biophysics: Structure and dynamics." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/305369.

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The phospholipid membrane is a self-assembled, dynamic molecular system that may exist alone in association with only water, or in complex systems comprised of multiple lipid types and proteins. In this dissertation the intra- and inter-molecular forces responsible for the atomistic, molecular and collective equilibrium structure and dynamics are studied by nuclear magnetic resonance spectroscopy (NMR). The multinuclear NMR measurements and various experimental techniques are able to provide data that enable the characterization of the hierarchical spatio-temporal organization of the phospholi
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50

Šmít, Daniel. "Analysis of dynamical interactions of axon shafts and their biophysical modelling." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066095/document.

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La fasciculation des axones joue un rôle essentiel dans le développement des réseaux neuronaux. Cependant, la dynamique de la fasciculation axonale, ainsi que les mécanismes biophysiques à l’œuvre dans ce processus, demeurent encore très mal compris. En vue d'étudier les mécanismes de fasciculation d'axones ex vivo, nous avons développé un système modèle simple, constitué par des explants d'épithélium olfactif de souris embryonnaires en culture, à partir desquels poussent les axones des neurones sensoriels olfactifs. Grâce à une étude en vidéomicroscopie, nous avons observé que ces axones inte
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