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Artigos de revistas sobre o tema "CASC20"

Autor: Grafiati

Publicado: 7 de junho de 2025

Última modificação: 2 de agosto de 2025

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1

Chayd, Nafea M., Mohammad Khalaj-Kondori, Reza Safaralizadeh, and Feizi Mohammad Ali Hosseinpour. "Effects of capecitabine chemotherapy on the expression of CASC18, CASC19, and CASC20 lncRNAs in patients with colorectal cancer and the HCT-116 colorectal cancer cell line." Pharmacia 72 (February 27, 2025): 1–13. https://doi.org/10.3897/pharmacia.72.e145066.

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Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths. Capecitabine is a key chemotherapy drug for colorectal cancer (CRC). Long non-coding RNAs (lncRNAs) play a role in the pathogenic pathways associated with colorectal cancer. This investigation compared the expression patterns of CASC18, CASC19, and CASC20 in CRC patients before and after chemotherapy, as well as in healthy individuals. The effects of capecitabine on cell viability, apoptosis, cell cycle, and the expressions of CASC18, CASC19, and CASC20 were examined using HCT-116 cells. Methods: CASC18, C

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2

Chayd, Nafea M., Mohammad Khalaj-Kondori, Reza Safaralizadeh, and Mohammad Ali Hosseinpour Feizi. "Effects of capecitabine chemotherapy on the expression of CASC18, CASC19, and CASC20 lncRNAs in patients with colorectal cancer and the HCT-116 colorectal cancer cell line." Pharmacia 72 (February 27, 2025): 1–13. https://doi.org/10.3897/pharmacia.72.e145066.

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Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths. Capecitabine is a key chemotherapy drug for colorectal cancer (CRC). Long non-coding RNAs (lncRNAs) play a role in the pathogenic pathways associated with colorectal cancer. This investigation compared the expression patterns of CASC18, CASC19, and CASC20 in CRC patients before and after chemotherapy, as well as in healthy individuals. The effects of capecitabine on cell viability, apoptosis, cell cycle, and the expressions of CASC18, CASC19, and CASC20 were examined using HCT-116 cells. Methods: CASC18, C

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3

Yan, Winston X., Pratyusha Hunnewell, Lauren E. Alfonse, et al. "Functionally diverse type V CRISPR-Cas systems." Science 363, no. 6422 (2018): 88–91. http://dx.doi.org/10.1126/science.aav7271.

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Type V CRISPR-Cas systems are distinguished by a single RNA-guided RuvC domain-containing effector, Cas12. Although effectors of subtypes V-A (Cas12a) and V-B (Cas12b) have been studied in detail, the distinct domain architectures and diverged RuvC sequences of uncharacterized Cas12 proteins suggest unexplored functional diversity. Here, we identify and characterize Cas12c, -g, -h, and -i. Cas12c, -h, and -i demonstrate RNA-guided double-stranded DNA (dsDNA) interference activity. Cas12i exhibits markedly different efficiencies of CRISPR RNA spacer complementary and noncomplementary strand cle

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4

Li, Q. Y., K. Yang, F. G. Liu та ін. "Long noncoding RNA CASC2c inhibited cell proliferation in hepatocellular carcinoma by inactivated ERK1/2 and Wnt/β-catenin signaling pathway". Clinical and Translational Oncology 22, № 3 (2019): 302–10. http://dx.doi.org/10.1007/s12094-019-02223-7.

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Abstract Purpose Long non-coding RNAs (lncRNAs) have been shown to play important roles in tumorigenesis, but their biological functions and the underlying molecular mechanisms remain unclear. Alternative splicing of five exons results in three transcript variants of cancer susceptibility 2 (CASC2): the lncRNAs CASC2a, CASC2b, and CASC2c. CASC2a/b have been found to have crucial regulatory functions in a number of malignancies, but few studies have examined the effects of CASC2c in cancers. The objective of the study was to investigate the role of CASC2c in the proliferation and apoptosis of h

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5

Rong, Shi Song, and Xinting Yu. "Phenotypic and Genetic Links between Body Fat Measurements and Primary Open-Angle Glaucoma." International Journal of Molecular Sciences 24, no. 4 (2023): 3925. http://dx.doi.org/10.3390/ijms24043925.

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The phenotypic and genetic links between body fat phenotypes and primary open-angle glaucoma (POAG) are unclear. We conducted a meta-analysis of relevant longitudinal epidemiological studies to evaluate the phenotypic link. To identify genetic links, we performed genetic correlation analysis and pleiotropy analysis of genome-wide association study summary statistics datasets of POAG, intraocular pressure (IOP), vertical cup-to-disc ratio, obesity, body mass index (BMI), and waist-to-hip ratio. In the meta-analysis, we first established that obese and underweight populations have a significantl

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6

Hatzikotoulas, K., M. J. Clark, S. J. Macinnes, E. Zeggini, and M. J. Wilkinson. "The long non-coding RNA CASC20 is a susceptibility locus for heterotopic ossification: results of a genome-wide association study." Osteoarthritis and Cartilage 26 (April 2018): S156. http://dx.doi.org/10.1016/j.joca.2018.02.337.

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7

Tan, Lee Ling, Elena Heng, Chung Yan Leong, et al. "Application of Cas12j for Streptomyces Editing." Biomolecules 14, no. 4 (2024): 486. http://dx.doi.org/10.3390/biom14040486.

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In recent years, CRISPR-Cas toolboxes for Streptomyces editing have rapidly accelerated natural product discovery and engineering. However, Cas efficiencies are oftentimes strain-dependent, and the commonly used Streptococcus pyogenes Cas9 (SpCas9) is notorious for having high levels of off-target toxicity effects. Thus, a variety of Cas proteins is required for greater flexibility of genetic manipulation within a wider range of Streptomyces strains. This study explored the first use of Acidaminococcus sp. Cas12j, a hypercompact Cas12 subfamily, for genome editing in Streptomyces and its poten

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8

Drojetzki, Lawrence, and Mieczyslaw Porowski. "Outdoor Climate as a Decision Variable in the Selection of an Energy-Optimal Refrigeration System Based on Natural Refrigerants for a Supermarket." Energies 16, no. 8 (2023): 3375. http://dx.doi.org/10.3390/en16083375.

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This paper presents the results of a simulation study on the selection of an energy-optimal refrigeration system based on natural refrigerants as a function of outdoor climate parameters as a decision variable in a supermarket application. Simulations were conducted for twelve locations. Three new original refrigeration systems were presented: Cascade R744/R717 which is an advanced booster extended with an ammonia condensing system (CASC_1); Cascade R744/R717 with CO2 pump-fed MT and pressure-fed LT evaporators (CASC_2); and the R717 booster with CO2 pump-fed MT and LT evaporators (CB_NH3). As

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9

Glover, Nicholas R., and Alan S. Tracey. "Structure, modelling, and molecular dynamics studies of the inhibition of protein tyrosine phosphatase 1B by sulfotyrosine peptides." Biochemistry and Cell Biology 77, no. 5 (1999): 469–86. http://dx.doi.org/10.1139/o99-056.

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The protein tyrosine phosphatases comprise a class of enzymes that are crucial for the regulation of a number of cellular processes. Because of this, they are attracting increasing attention, not only as legitimate therapeutic targets, but also because of their relationship to many fundamental cellular processes. Certain sulfotyrosine peptides derived from casein are known to be good inhibitors of the protein tyrosine phosphatase, PTP1B. In this study, NMR transfer nuclear Overhauser effect studies have been used to ascertain the bound-state conformation adopted by the 12-amino acid residue ca

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10

Bacciagaluppi, C. "Historical performance, past and present." Early Music 40, no. 1 (2012): 161–63. http://dx.doi.org/10.1093/em/cas020.

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11

Smith, D. J. "Revelatory Sweelinck." Early Music 40, no. 4 (2012): 703–5. http://dx.doi.org/10.1093/em/cas120.

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12

Tao, Ling, Ping Tian, Li Yang, and Xiangyang Guo. "lncRNA CASC2 Enhances 131I Sensitivity in Papillary Thyroid Cancer by Sponging miR-155." BioMed Research International 2020 (October 19, 2020): 1–12. http://dx.doi.org/10.1155/2020/7183629.

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Long noncoding RNA cancer susceptibility candidate 2 (CASC2) has been reported to play an anticancer role in papillary thyroid cancer (PTC). Radioiodine (131I) is a common option for the treatment of PTC. However, the role and mechanism of CASC2 in 131I sensitivity remain unclear. In this study, 131I-resistant cells were constructed through continuous treatment of 131I. The expression levels of CASC2 and miR-155 were measured by qRT-PCR. The IC50 of 131I was analyzed by cell viability using MTT assay. Flow cytometry was conducted to determine cell apoptosis induced by 131I. The association bet

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13

Noriega-Rivera, Ricardo, Mariela Rivera-Serrano, Robert J. Rabelo-Fernandez, Josué Pérez-Santiago, Fatima Valiyeva, and Pablo E. Vivas-Mejía. "Upregulation of the Long Noncoding RNA CASC10 Promotes Cisplatin Resistance in High-Grade Serous Ovarian Cancer." International Journal of Molecular Sciences 23, no. 14 (2022): 7737. http://dx.doi.org/10.3390/ijms23147737.

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Despite initial responses to first-line treatment with platinum and taxane-based combination chemotherapy, most high-grade serous ovarian carcinoma (HGSOC) patients will relapse and eventually develop a cisplatin-resistant fatal disease. Due to the lethality of this disease, there is an urgent need to develop improved targeted therapies against HGSOC. Herein, we identified CASC10, a long noncoding RNA upregulated in cisplatin-resistant ovarian cancer cells and ovarian cancer patients. We performed RNA sequencing (RNA-seq) in total RNA isolated from the HGSOC cell lines OVCAR3 and OV-90 and the

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14

Yang, Huihui, Quan e. Kan, Yong Su, and Hua Man. "Long Non-Coding RNA CASC2 Improves Diabetic Nephropathy by Inhibiting JNK Pathway." Experimental and Clinical Endocrinology & Diabetes 127, no. 08 (2018): 533–37. http://dx.doi.org/10.1055/a-0629-9958.

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AbstractIt’s known that long non-coding RNA CASC2 overexpression inhibit the JNK pathway in some disease models, while JNK pathway activation exacerbates diabetic nephropathy. Therefore we speculate that long non-coding RNA CASC2 can improve diabetic nephropathy by inhibiting JNK pathway. Thus, our study was carried out to investigate the involvement of CASC2 in diabetic nephropathy. We found that serum level of CASC2 was significantly lower in diabetic nephropathy patients than in normal people, and serum level of CASC2 showed no significant correlations with age, gender, alcohol consumption

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15

Yuan, Ye, Jiaxin Ye, Xujing Zhang, and Zhisu Liu. "LncRNA CASC2 Regulate Cell Proliferation and Invasion by Targeting miR-155/SOCS1 Axis in Hepatocellular Carcinoma." Journal of Oncology 2023 (February 10, 2023): 1–9. http://dx.doi.org/10.1155/2023/8457112.

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Long noncoding RNAs (lncRNAs) have been reported to be involved in the development and progression of various human malignancies. However, the role of lncRNA CASC2 in hepatocellular carcinoma (HCC) remains mostly unknown. The aim of this study was to investigate the potential roles and underlying mechanisms of CASC2 in HCC progression. We found that CASC2 expressions were downregulated in HCC tissue samples and cell lines. The clinical assays revealed that lower levels of CASC2 were associated with the TNM stage, lymph node metastasis, and a poorer prognosis specific to HCC patients. Overexpre

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16

Yuan, Bowei, Congcong Yuan, Lulu Li, Miao Long, and Zeliang Chen. "Application of the CRISPR/Cas System in Pathogen Detection: A Review." Molecules 27, no. 20 (2022): 6999. http://dx.doi.org/10.3390/molecules27206999.

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Early and rapid diagnosis of pathogens is important for the prevention and control of epidemic disease. The polymerase chain reaction (PCR) technique requires expensive instrument control, a special test site, complex solution treatment steps and professional operation, which can limit its application in practice. The pathogen detection method based on the clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated protein (CRISPR/Cas) system is characterized by strong specificity, high sensitivity and convenience for detection, which is more suitable for practica

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17

Peng, Sida, Qingqing Yang, Yuhang Pan, et al. "Expression of the long noncoding RNA CASC2 in acute myeloid leukemia and its prognostic significance." Indian Journal of Cancer 61, no. 4 (2024): 728–35. https://doi.org/10.4103/ijc.ijc_1365_20.

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Abstract Background: Cancer susceptibility candidate 2 (CASC2) was found underexpressed in multiple types of human malignancies. However, the specific role of CASC2 in AML remains uncertain. The purpose of this study is to explore the expression of CASC2 in patients with AML and healthy donors and its prognostic significance in AML. Methods: Total RNA was isolated from bone marrow samples or peripheral blood samples of 87 patients with AML and 26 healthy adult donors. The expression of long noncoding RNA CASC2 was detected by quantitative real-time polymerase chain reaction. The association be

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18

Wang, Quanbing, and Changbin Zhang. "Inhibitory Role of Cucurbitacin B with Polylactic Acid Nanoparticles Carrying Long Non-Coding RNA (LncRNA) Cancer Susceptibility Candidate 2c (CASC2c) in Oral Cancer Cell Migration and Invasion Through Targeting of Signal Transcription and Activator of Transcription (STAT) Signaling Pathway." Science of Advanced Materials 13, no. 10 (2021): 1892–98. http://dx.doi.org/10.1166/sam.2021.4093.

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Polylactic acid nanoparticles (PLA-NPs) not only have the characteristics of NPs, but also can be used as drug carriers. In this experiment, PLA-NPs were used as nano-carriers to construct nano-drugs carrying cucurbitacin B and long non-coding RNA (lncRNA) cancer susceptibility candidate 2c (CASC2c) (lncRNA CASC2C), to intervene oral cancer cells followed by analysis of their effect on cell progression. CuB-PLA-NPs and CuB-PLANPs-CASC2c were prepared, and properties of two NPs and in vitro drug release were analyzed. Oral cancer cells were treated with CuB-PLA-NPs or CuB-PLA-NPs-CASC2c. MTT wa

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19

Zhu, Zheng-ming, Fang-teng Liu, and Xuan Chen. "Low Expression of LncRNA Cancer Susceptibility Candidate 2 and its Clinical Significance in Cancer Tissues." Cellular Physiology and Biochemistry 46, no. 4 (2018): 1643–49. http://dx.doi.org/10.1159/000489211.

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Background/Aims: Long noncoding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) is downregulated in various cancers and involved in both tumorigenesis and progression. The aim of this study was to assess the prognostic value of lncRNA CASC2 in cancer patients. Methods: We searched the Web of Science, PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and the Wanfang database to identify studies evaluating the prognostic value of lncRNA CASC2 in cancer patients. Pooled hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed-ef

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20

He, Minjie, Liang Tu, Ruo Shu та ін. "Long Noncoding RNA CASC2 Facilitated Wound Healing through miRNA-155/HIF-1α in Diabetic Foot Ulcers". Contrast Media & Molecular Imaging 2022 (24 червня 2022): 1–12. http://dx.doi.org/10.1155/2022/6291497.

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Diabetic foot ulcers (DFU) are among the serious complications which are closely linked to diabetes mellitus. However, there is still a lack of accurate and effective standard prevention and treatment programs for DFU. In this manuscript, we have investigated the function of lncRNA cancer susceptibility candidate 2 (CASC2)/miR-155/hypoxia-inducible factor 1-alpha (HIF-1α) in the wound healing of DFU. We have analyzed lncRNA CASC2`s expression in the marginal tissues of ulcers in patients and mice with DFU. Additionally, the interaction relationship and mechanism between lncRNA CASC2, miR-155,

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21

Marques da Silva, Janimara, Gleica Maria Correia Martins, Henrique Costa Hermenegildo da Silva, and Flávia de Flávia De Barros Prado Moura. "CONHECIMENTO ECOLÓGICO TRADICIONAL E EXTRATIVISMO DO ANGICO-DE-CAROÇO NO SEMIÁRIDO ALAGOANO." Revista Ouricuri 4, no. 2 (2019): 097–114. https://doi.org/10.59360/ouricuri.vol4.i2.a6416.

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O extrativismo no semiárido brasileiro tem sido apontado como umfator de pressão sobre as espécies das caatingas. O objetivo deste trabalho foiavaliar o extrativismo do angico-de-caroço no município de Senador RuiPalmeira, semiárido de Alagoas, visando identificar o conhecimento associadoàs práticas adotadas para extração de cascas e madeira. A extração da cascaé feita visando abastecer curtumes e a principal forma de obtenção é atravésdo corte raso ou poda. O angico rebrota após o corte e, nos primeiros trêsanos, pode ser consorciado com palma, milho e feijão. O ciclo de corte varia de4 a 20

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22

Liu, Panpan, Huali Zhang, Haizhu Zeng, et al. "LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis." Therapeutic Advances in Respiratory Disease 15 (January 2021): 175346662110280. http://dx.doi.org/10.1177/17534666211028072.

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Aims: Chronic obstructive pulmonary disease (COPD) is a systemic disease. Several long non-coding RNAs (lncRNAs) have been identified to be aberrantly expressed in COPD patients. This study investigated the role of lncRNA cancer susceptibility candidate 2 (CASC2) in COPD, as well as its potential mechanism. Methods: Fifty smokers with COPD and another 50 smokers without COPD were recruited. Receiver operating characteristic curve was constructed to assess the diagnostic value of CASC2 in COPD patients. 16HBE cells were treated with cigarette smoke extract (CSE) to establish a cell model. qRT-P

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23

Skiriute, Daina, Rytis Stakaitis, Giedrius Steponaitis, Arimantas Tamasauskas, and Paulina Vaitkiene. "The Role of CASC2 and miR-21 Interplay in Glioma Malignancy and Patient Outcome." International Journal of Molecular Sciences 21, no. 21 (2020): 7962. http://dx.doi.org/10.3390/ijms21217962.

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Recently long non-coding RNAs (lncRNAs) were highlighted for their regulatory role in tumor biology. The novel human lncRNA cancer susceptibility candidate 2 (CASC2) has been characterized as a potential tumor suppressor in several tumor types. However, the roles of CASC2 and its interplay with miR-21 in different malignancy grade patient gliomas remain unexplored. Here we screened 99 different malignancy grade astrocytomas for CASC2, and miR-21 gene expression by real-time quantitative polymerase chain reaction (RT-qPCR) in isocitrate dehydrogenase 1 (IDH1) and O-6-methylguanine methyltransfe

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24

Sahu, Sonu Priya, Raj Kumar Joshi, and Rukmini Mishra. "Genome Editing Technologies towards Tomato Improvement: Recent Advances and Future Perspectives." Journal of Experimental Biology and Agricultural Sciences 12, no. 4 (2024): 537–56. http://dx.doi.org/10.18006/2024.12(4).537.556.

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Tomato (Solanum lycopersicon L.) is the world's second major vegetable crop and a superior model plant for studies on fruit biology. However, the changing climatic conditions are hugely impacting the yield and quality of tomato. CRISPR/Cas9 technology has been widely used in tomato breeding for enhanced disease resistance, herbicide tolerance, domestication and urban farming of wild tomato, and improved fruit yield and quality. Furthermore, new and advanced editing systems like Cas12a, Cas12b, base editing, and prime editing have been recently applied for high-precision tomato improvement. CRI

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25

Min, Xiao-Qiang, and Yan Xie. "LncRNA CASC2 Alleviates the Progression of Diabetic Nephropathy by Regulating the miR-144/SOCS2 Signalling Axis." Kidney and Blood Pressure Research 45, no. 6 (2020): 837–49. http://dx.doi.org/10.1159/000508078.

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<b><i>Background:</i></b> Diabetic nephropathy constitutes a large proportion of end-stage kidney failure in diabetic patients. However, the underlying molecular mechanisms remain unclear. <b><i>Methods:</i></b> Db/db diabetic mouse models and high glucose (HG)-induced human renal mesangial cells (HRMCs) were used as research models in vivo and in vitro. The expression of cancer susceptibility candidate 2 (CASC2) was quantified by qRT-PCR. The regulatory role of CASC2 in cell apoptosis, inflammatory factor release, and fibrosis was verified by fl

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26

Giselbrecht, E. "Finding the voice of the Italian Baroque." Early Music 40, no. 1 (2012): 142–45. http://dx.doi.org/10.1093/em/cas002.

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Ward, M. "Renaissance sacred vocal music." Early Music 40, no. 1 (2012): 137–39. http://dx.doi.org/10.1093/em/cas010.

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Neal, T. J. D. "Byrd at home." Early Music 40, no. 1 (2012): 160–61. http://dx.doi.org/10.1093/em/cas021.

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Barbieri, P. "Harpsichords and spinets in late Baroque Rome." Early Music 40, no. 1 (2012): 55–72. http://dx.doi.org/10.1093/em/cas023.

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Rifkin, J. "Bach's chorus: more of the same." Early Music 40, no. 1 (2012): 165–66. http://dx.doi.org/10.1093/em/cas024.

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Schulenberg, D. "Bach's temperament." Early Music 40, no. 1 (2012): 166–67. http://dx.doi.org/10.1093/em/cas025.

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Lindley, M. "Bach's temperament." Early Music 40, no. 1 (2012): 167. http://dx.doi.org/10.1093/em/cas026.

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Hollick, D. "Gustav Leonhardt (1928-2012)." Early Music 40, no. 1 (2012): 164. http://dx.doi.org/10.1093/em/cas027.

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Parrott, A. "High clefs and down-to-earth transposition: a brief defence of Monteverdi." Early Music 40, no. 1 (2012): 81–86. http://dx.doi.org/10.1093/em/cas028.

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Annibaldi, C. "Was Frescobaldi a chameleonic scribe?" Early Music 40, no. 1 (2012): 87–90. http://dx.doi.org/10.1093/em/cas029.

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Clapton, N. "The singularity of Alfred Deller (1912-1979)." Early Music 40, no. 2 (2012): 291–96. http://dx.doi.org/10.1093/em/cas040.

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Leavis, R. "Correspondence." Early Music 40, no. 3 (2012): 544. http://dx.doi.org/10.1093/em/cas050.

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Zohn, S. "A trove of Telemann." Early Music 40, no. 2 (2012): 331–37. http://dx.doi.org/10.1093/em/cas060.

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Sawkins, L. "French motets catalogued." Early Music 40, no. 3 (2012): 501–2. http://dx.doi.org/10.1093/em/cas070.

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Gale, M. "Lute treasures." Early Music 40, no. 3 (2012): 507–9. http://dx.doi.org/10.1093/em/cas080.

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Lebedinski, E., and M. Laube. "Baroque Conference." Early Music 40, no. 3 (2012): 540–42. http://dx.doi.org/10.1093/em/cas090.

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42

Holman, P. "A Purcell manuscript lost and found." Early Music 40, no. 3 (2012): 469–87. http://dx.doi.org/10.1093/em/cas100.

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Honisch, E. "Bohemian sacred music." Early Music 40, no. 4 (2012): 699–702. http://dx.doi.org/10.1093/em/cas110.

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44

Robert, G. R. "Courtly contexts for Moravian Hanak music in the 17th and 18th centuries." Early Music 40, no. 4 (2012): 577–91. http://dx.doi.org/10.1093/em/cas122.

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Roche, E. "Myth, magic and ancient history in Handel." Early Music 40, no. 4 (2012): 715–18. http://dx.doi.org/10.1093/em/cas123.

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46

Sutcliffe, W. D. "Haydn chamber music." Early Music 40, no. 4 (2012): 718–21. http://dx.doi.org/10.1093/em/cas124.

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47

Talbot, M. "Interesting Historical Figures." Early Music 40, no. 4 (2012): 708–10. http://dx.doi.org/10.1093/em/cas125.

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Eisenhardt, L. "Baroque guitar accompaniment: where is the bass?" Early Music 42, no. 1 (2013): 73–84. http://dx.doi.org/10.1093/em/cas126.

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49

Horyna, M., and V. Manas. "Two mid-16th-century manuscripts of polyphonic music from Brno." Early Music 40, no. 4 (2012): 553–75. http://dx.doi.org/10.1093/em/cas127.

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Chew, G. "The public and private affairs of Josepha Duschek: a reinterpretation of Mozart's Bella mia fiamma, addio KV528." Early Music 40, no. 4 (2012): 639–57. http://dx.doi.org/10.1093/em/cas128.

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