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Artigos de revistas sobre o tema "Cellule stromale lymphoïde"

Autor: Grafiati

Publicado: 21 de setembro de 2024

Última modificação: 31 de julho de 2025

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1

Shakhpazyan, Nikolay, Liudmila Mikhaleva, Arkady Bedzhanyan, et al. "Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets." Biomedicines 11, no. 9 (2023): 2361. http://dx.doi.org/10.3390/biomedicines11092361.

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Colorectal cancer (CRC) is a major health burden worldwide and is the third most common type of cancer. The early detection and diagnosis of CRC is critical to improve patient outcomes. This review explores the intricate interplay between the tumor microenvironment, stromal interactions, and the progression and metastasis of colorectal cancer. The review begins by assessing the gut microbiome’s influence on CRC development, emphasizing its association with gut-associated lymphoid tissue (GALT). The role of the Wnt signaling pathway in CRC tumor stroma is scrutinized, elucidating its impact on

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Matsumoto, Mitsuru, Kikue Iwamasa, Paul D. Rennert та ін. "Involvement of Distinct Cellular Compartments in the Abnormal Lymphoid Organogenesis in Lymphotoxin-α-Deficient Mice and Alymphoplasia (aly) Mice Defined by the Chimeric Analysis". Journal of Immunology 163, № 3 (1999): 1584–91. http://dx.doi.org/10.4049/jimmunol.163.3.1584.

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Abstract Both lymphotoxin-α (LTα)-deficient mice and alymphoplasia (aly) mice, a natural mutant strain, manifest a quite similar phenotype: lack of lymph nodes (LN) and Peyer’s patches (PP), with disturbed spleen architecture. The mechanisms underlying the defective lymphoid organogenesis in these mice were investigated by generating aggregation chimeras; ex vivo fused morulae were implanted into pseudo-pregnant host females and allowed to develop to term. Chimeric mice between LTα-deficient mice and wild-type mice restored LN and PP almost completely, suggesting that LTα expressed by circulat

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Nitta, Takeshi. "Understanding the Thymic Microenvironment: the Cellular and Molecular Basis of T Cell Development." Central Asian Journal of Medical Sciences 2, no. 2 (2016): 111–26. http://dx.doi.org/10.24079/cajms.2016.02.002.

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Objectives: The thymus is a primary lymphoid organ that provides specialized microenvironment for T cell development. A variety of thymic stromal cells form the thymic tissue architecture and critically regulate the development and repertoire selection of T cells. Methods: We reviewed historical and recent studies on thymic stromal cells, especially focusing on the well-characterized functions of thymic epithelial cells (TECs) and the significance of as yet less characterized non-TEC thymic stromal cells and hematopoietic antigen-presenting cells in the regulation of T cell development. Result

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Shakfa, Noor, Ferris Nowlan, Elizabeth Sunnucks, et al. "Abstract 155: Spatial analysis of tumor-immune-stromal cellular phenotypes and microenvironments in pancreatic cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 155. https://doi.org/10.1158/1538-7445.am2025-155.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is notoriously resistant or refractory to both modern and conventional therapies. These tumors are characterized by heterogeneous malignant epithelial lesions and immune cells embedded within a highly dense and complex stroma. The unique, multi-compartmental tumor microenvironment (TME) —encompassing diverse lineages such as fibroblasts, mural cells, endothelial cells, lymphoid and myeloid populations, cancer cells, and a rich extracellular matrix—indicates the presence of intricate cellular networks that drive tumor progression. Efforts to prof

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Shadlinskaya, S. V. "Cellular composition and microanatomy of lymphoid formations of the vestibule of the vagina in postnatal ontogenesis." Sechenov Medical Journal 10, no. 1 (2019): 57–62. http://dx.doi.org/10.47093/22187332.2019.1.57-62.

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Aim - presents data on the number of cells of the lymphoid series and the cellular composition of the lymphoid tissue in the mucosa of the vaginal vestibule at diﬀerent age periods of ontogenesis. Materials and methods. The study material was preparations of the vaginal vestibule taken from 45 women of diﬀerent ages (from newborns to 75 years). By age periods, the material was subdivided according to the standard scheme of age periodization. Cross sections of the organ wall were stained with hematoxylin - eosin and according to Van Gieson. In a number of cases, the silvering of Grimelius was p

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Cakala-Jakimowicz, Marta, Paulina Kolodziej-Wojnar, and Monika Puzianowska-Kuznicka. "Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview." Cells 10, no. 11 (2021): 3148. http://dx.doi.org/10.3390/cells10113148.

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Aging affects all tissues and organs. Aging of the immune system results in the severe disruption of its functions, leading to an increased susceptibility to infections, an increase in autoimmune disorders and cancer incidence, and a decreased response to vaccines. Lymph nodes are precisely organized structures of the peripheral lymphoid organs and are the key sites coordinating innate and long-term adaptive immune responses to external antigens and vaccines. They are also involved in immune tolerance. The aging of lymph nodes results in decreased cell transport to and within the nodes, a dist

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Jansen, Caroline S., BaoHan Vo, Ewelina Sobierajska, et al. "Abstract B030: Form and function in intratumoral immune organization: Understanding the cellular composition of TCF1+ CD8+ T cell niches in human cancer." Cancer Research 83, no. 16_Supplement (2023): B030. http://dx.doi.org/10.1158/1538-7445.kidney23-b030.

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Abstract Tumor infiltrating T cells are a positive prognosticator in many tumor types, and our prior work demonstrated that in renal cell carcinoma, patients with higher CD8 T cell infiltration have improved survival (Jansen Nature 2019). We described that this T cell response is supported by TCF1+ stem-like CD8 T cells, which reside within dense regions of closely clustered antigen presenting cells within the tumor. Interestingly, aggregations of immune cells have also been described in other settings and termed ‘tertiary lymphoid structures’ (TLS), raising an important question of whether th

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Voermans, Carlijn, and Mette D. Hazenberg. "Cellular therapies for graft-versus-host disease: a tale of tissue repair and tolerance." Blood 136, no. 4 (2020): 410–17. http://dx.doi.org/10.1182/blood.2019000951.

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Abstract The success of allogeneic hematopoietic cell transplantation depends heavily on the delicate balance between the activity of the donor immune system against malignant and nonmalignant cells of the recipient. Abrogation of alloreactivity will lead to disease relapse, whereas untamed allo-immune responses will lead to lethal graft-versus-host disease (GVHD). A number of cell types have been identified that can be used to suppress alloreactive immune cells and prevent lethal GVHD in mice. Of those, mesenchymal stromal cells and, to a lesser extent, regulatory T cells have demonstrated ef

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Baron, Chloé S., Serine Avagyan, Song Yang, Aaron McKenna, and Leonard Zon. "Abstract A27: Cellular barcoding of the leukemic niche reveals an apelin-mediated clonal expansion of niche endothelial and mesenchymal stromal cell clones." Blood Cancer Discovery 4, no. 3_Supplement (2023): A27. http://dx.doi.org/10.1158/2643-3249.aml23-a27.

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Abstract Hematopoietic stem and progenitor cells (HSPCs) reside in niches that provide regulatory signals for their function. Perturbations such as acute leukemia induce cellular and molecular insults to the niche to support disease progression. Mutation of the MYC oncogene family is a frequent event leading to leukemogenesis. We developed a new zebrafish model of acute erythroid leukemia (AEL) by overexpression of human CMYC under the blood specific promotor draculin (drl). Analyses of drl:CMYC marrows demonstrated a significant expansion of progenitors and a decrease of erythroid, lymphoid a

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Aggarwal, Vaishali, Radhika Srinivasan, Amanjit Bal, et al. "Mutational Spectrum of Stromal Genes By Whole Exome Sequencing and Stromal-Cellular Interaction in Diffuse Large B-Cell Lymphoma." Blood 126, no. 23 (2015): 2649. http://dx.doi.org/10.1182/blood.v126.23.2649.2649.

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Abstract Introduction: Morphological sub-classification of DLBCL into germinal center B-cell-like (GCB) and activated B-cell like (ABC) lacks sufficient reproducibility for risk stratification and predicting survival based on International Prognostic Index (IPI). The importance of stromal cells and their cross-talk with lymphoma cells is important in lymphomagenesis and progression. We postulate that mutations in stromal genes may regulate the rate of tumor progression in DLBCL and understanding the stromal-cellular interaction in DLBCL may help evolve better markers of prognostication and ide

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Belli, Carmen, Gabriele Antonarelli, Matteo Repetto, Luca Boscolo Bielo, Edoardo Crimini, and Giuseppe Curigliano. "Targeting Cellular Components of the Tumor Microenvironment in Solid Malignancies." Cancers 14, no. 17 (2022): 4278. http://dx.doi.org/10.3390/cancers14174278.

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Cancers are composed of transformed cells, characterized by aberrant growth and invasiveness, in close relationship with non-transformed healthy cells and stromal tissue. The latter two comprise the so-called tumor microenvironment (TME), which plays a key role in tumorigenesis, cancer progression, metastatic seeding, and therapy resistance. In these regards, cancer-TME interactions are complex and dynamic, with malignant cells actively imposing an immune-suppressive and tumor-promoting state on surrounding, non-transformed, cells. Immune cells (both lymphoid and myeloid) can be recruited from

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Reglero-Real, Natalia, Diego García-Weber, and Jaime Millán. "Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue." Mediators of Inflammation 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/7650260.

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During the inflammatory response, immune cells egress from the circulation and follow a chemotactic and haptotactic gradient within the tissue, interacting with matrix components in the stroma and with parenchymal cells, which guide them towards the sites of inflammation. Polarized epithelial cells compartmentalize tissue cavities and are often exposed to inflammatory challenges such as toxics or infections in non-lymphoid tissues. Apicobasal polarity is critical to the specialized functions of these epithelia. Indeed, a common feature of epithelial dysfunction is the loss of polarity. Here we

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Szeifert, György T., Isabelle Salmon, Sandrine Rorive, et al. "Does gamma knife surgery stimulate cellular immune response to metastatic brain tumors? A histopathological and immunohistochemical study." Journal of Neurosurgery 102, Special_Supplement (2005): 180–84. http://dx.doi.org/10.3171/sup.2005.102.s_supplement.0180.

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Object. The aim of this study was to analyze the cellular immune response and histopathological changes in secondary brain tumors after gamma knife surgery (GKS). Methods. Two hundred ten patients with cerebral metastases underwent GKS. Seven patients underwent subsequent craniotomy for tumor removal between 1 and 33 months after GKS. Four of these patients had one tumor, two patients had two tumors, and one patient had three. Histological and immunohistochemical investigations were performed. In addition to routine H & E and Mallory trichrome staining, immunohistochemical reactions were c

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Szeifert, György T., Isabelle Salmon, Sandrine Rorive, et al. "Does gamma knife surgery stimulate cellular immune response to metastatic brain tumors? A histopathological and immunohistochemical study." Journal of Neurosurgery 102 (January 2005): 180–84. http://dx.doi.org/10.3171/jns.2005.102.s_supplement.0180.

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Object.The aim of this study was to analyze the cellular immune response and histopathological changes in secondary brain tumors after gamma knife surgery (GKS).Methods.Two hundred ten patients with cerebral metastases underwent GKS. Seven patients underwent subsequent craniotomy for tumor removal between 1 and 33 months after GKS. Four of these patients had one tumor, two patients had two tumors, and one patient had three. Histological and immunohistochemical investigations were performed. In addition to routine H & E and Mallory trichrome staining, immunohistochemical reactions were cond

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Humby, Frances, Myles Lewis, Nandhini Ramamoorthi, et al. "Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients." Annals of the Rheumatic Diseases 78, no. 6 (2019): 761–72. http://dx.doi.org/10.1136/annrheumdis-2018-214539.

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ObjectivesTo unravel the hierarchy of cellular/molecular pathways in the disease tissue of early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship with clinical phenotypes and treatment response/outcomes longitudinally.Methods144 consecutive treatment-naïve early RA patients (<12 months symptoms duration) underwent ultrasound-guided synovial biopsy before and 6 months after disease-modifying antirheumatic drug (DMARD) initiation. Synovial biopsies were analysed for cellular (immunohistology) and molecular (NanoString) characteristics and results compared w

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Zhu, Jiang, Yi Zhang, Nacksung Kim, et al. "Osteoblasts Support Early B Lymphoiesis as well as Stem Cell Proliferation and Myelopoiesis: Identification of the Mammalian Cellular Analog of the Bursa of Fabricius." Blood 104, no. 11 (2004): 508. http://dx.doi.org/10.1182/blood.v104.11.508.508.

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Abstract The self-renewal, survival and differentiation of hematopoietic stem cells (HSC) are greatly influenced by the activities of neighboring osteoblasts and non-osteogenic bone marrow (BM) stromal cells such as fibroblasts, endothelial cells and adipocytes. Previously, we showed that osteoblasts from human long bones support the in vitro self-renewal as well as myeloid differentiation of human CD34+ cord blood cells. Recently, Li’s and Scadden’s groups provided in vivo evidence indicating a primary role of trabecular osteoblasts as a major component of HSC niche and of stromal osteoblasti

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Ho, Anthony D., Patrick Horn, Marco Hennrich, et al. "Proteomics Analysis of Cellular Network in Human Bone Marrow Reveals Lineage Skewing Towards Megakaryocytes and Decrease in Lymphoid Development upon Aging." Blood 128, no. 22 (2016): 2658. http://dx.doi.org/10.1182/blood.v128.22.2658.2658.

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Abstract Background: Whereas proteomics analyses at a cellular level have been performed in murine HPC, most proteomics studies on human material have thus far focused on examining human tissues with a mixture of cell types and not at a specific cellular level. Whole proteomics analyses might reveal genuine molecular alterations und mechanisms of aging on human hematopoietic cells. Aim: To identify the age-related molecular changes in human hematopoietic progenitor cells (HPC) as well as in the cellular elements of the human bone marrow niche, we have applied mass spectrometry-based platform f

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Vorontsova, Z. A., and E. F. Kudaeva. "Cellular reactions of the mucous membrane of the intestinal system after uranium incorporation." Morphological newsletter 28, no. 1 (2020): 9–15. http://dx.doi.org/10.20340/mv-mn.2020.28(1):9-15.

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A pilot study, which was performed on white laboratory male rats and included a morphological study of the mucous membrane of the jejunum and colon, revealed the long-term effect of a single oral exposure to an aqueous solution of depleted uranium oxides; this supported dynamic changes in the studied criteria determining metabolic, regenerative, and local regulatory processes in one, three and six months. A lymphoid component appeared to be the criterion of high radio sensitivity and a marker of nonspecific protection indicating deterioration of homeostasis. In the time dynamics of long-term p

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Shanmugam, Vignesh, Neriman Tokcan, Daniel Chafamo, et al. "Genome-Scale High-Resolution Spatial Mapping of the Pro-Tumorigenic Cellular Niche in Classic Hodgkin Lymphoma." Blood 142, Supplement 1 (2023): 175. http://dx.doi.org/10.1182/blood-2023-185522.

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Introduction: A fundamental hallmark of cancer is that tumor cells repurpose the tissue microenvironment to promote their own survival. An increased understanding of these mechanisms may lead to improved microenvironment-directed therapies, particularly in lymphoid malignancies. In classic Hodgkin lymphoma (cHL), the rare malignant Hodgkin Reed Sternberg (HRS) cells are surrounded by a CD4+ T-cell and macrophage-rich inflammatory infiltrate. Recent multiplexed immunofluorescence studies suggest that the micron-scale niche around HRS cells is composed of distinct populations of PD-L1+ macrophag

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Capron, C., K. Jondeau, L. Casetti, et al. "Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727." Cell Death & Disease 5, no. 10 (2014): e1451-e1451. http://dx.doi.org/10.1038/cddis.2014.393.

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Abstract Chronic lymphoid leukemia (CLL) is characterized by the accumulation of functionally defective CD5-positive B lymphocytes. The clinical course of CLL is highly variable, ranging from a long-lasting indolent disease to an unpredictable and rapidly progressing leukemia requiring treatment. It is thus important to identify novel factors that reflect disease progression or contribute to its assessment. Here, we report on a novel STAT3-mediated pathway that characterizes CLL B cells-extended viability and oxidative stress control. We observed that leukemic but not normal B cells from CLL p

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Buckley, Paul R., Julie Chan, Cynthia Bishop, et al. "Highly Heterogeneous Cellular Composition and Neighborhood Architecture within the Follicular Lymphoma Tumor Microenvironment." Blood 144, Supplement 1 (2024): 4382. https://doi.org/10.1182/blood-2024-209877.

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The variable clinical course and response to treatment of Follicular Lymphoma (FL) is strongly influenced by its tumor microenvironment (TME). Indeed, cellular interactions dictate pro- and anti-tumor processes within the TME, although these mechanisms remain incompletely understood. Multiple bulk and single-cell studies have shed light on the TME with prognostic implications. For example, a macrophage gene signature as well as a ‘T cell depleted’ milieu have been associated with inferior clinical outcomes. Imaging Mass Cytometry (IMC) permits the multiplexed assessment of over 40 markers conc

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Song, Xiaofei, Xiaoqing Yu, Carlos M. Moran-Segura, G. Daniel Grass, Roger Li, and Xuefeng Wang. "Abstract 6245: Missed opportunity at the subcellular level: Enhancing the utility of cellular imaging modality in spatial transcriptomic profiling of tumor tissues." Cancer Research 84, no. 6_Supplement (2024): 6245. http://dx.doi.org/10.1158/1538-7445.am2024-6245.

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Abstract Mini-bulk or single-spot spatial transcriptomic technologies, such as GeoMX Digital Spatial Profiler (DSP), have revolutionized our ability to probe spatial heterogeneity and examine transcripts at a subcellular level. In cancer research, this level of granularity is crucial for uncovering the distinct gene expression signatures within specific compartments or structures of interest such as tumor, immune, stroma, and tertiary lymphoid structures. However, in most GeoMX DSP studies, the spatial information obtained from multiplex immunofluorescence imaging has been primarily used for i

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Kittrell, Caroline, Blake Sells, Lyndsay Young, Peggi Angel, and Richard Drake. "471 Defining proteomic and cellular elements of the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment with mass spectrometry imaging." Journal of Clinical and Translational Science 9, s1 (2025): 139. https://doi.org/10.1017/cts.2024.1064.

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Objectives/Goals: Currently, a lack of screening markers and targeted therapies prevent clinicians from successfully treating PDAC. Precision medicine may allow oncologists to better combat this disease. To personalize care, knowledge of tumor protein posttranslational modifications, extracellular matrix makeup, and infiltrating immune cells is imperative. Methods/Study Population: Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) was employed to characterize the N glycosylation state, the ECM composition, and immune cell populations present within 10 formalin f

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Damle, Rajendra N., Taraneh Banapour, Sonal Temburni, et al. "Remarkable Differences in Cellular Activation State and Migratory and Proliferative Potential among Clonal Cells Derived from Different Tissues of Chronic Lymphocytic Leukemia Patients." Blood 108, no. 11 (2006): 2817. http://dx.doi.org/10.1182/blood.v108.11.2817.2817.

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Abstract An antigen-independent process that takes place in the bone marrow (BM) leads to the birth of B cells from bone marrow precursors. Cross-talk between components of the microenvironment of BM or secondary lymphoid compartment(s), eg. spleen (SP), nurtures the subsequent evolution of B cells and governs in large part the natural history of normal B cells and B cell malignancies including chronic lymphocytic leukemia (B-CLL). Interaction of B cells with stromal elements confers upon them features enabling their transient sequestration, proliferation and extended survival. In this report

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Subramanian, Ajay, Neda Nemat-Gorgani, Timothy J. Ellis-Caleo, et al. "Abstract 5960: Identification and validation of sarcoma cellular ecosystems associated with prognosis and predictive of immunotherapy response." Cancer Research 83, no. 7_Supplement (2023): 5960. http://dx.doi.org/10.1158/1538-7445.am2023-5960.

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Abstract The tumor microenvironment contributes to tumorigenesis, disease progression, and response to therapy in soft tissue sarcomas (STSs). However, characterizing the malignant and stromal cells that make up STSs and correlating their abundance with clinical outcomes has proven difficult in fixed clinical specimens. We employed a machine learning framework called EcoTyper (Luca et al. Cell 2021) to identify cell type-specific transcriptional states and define tumor ecotypes consisting of co-occurring cell states from bulk transcriptomes. Analyzing 292 previously published STSs profiled by

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Kostakis, Alexandros, Andrea Behanova, Iliana Kerzeli, et al. "Abstract 3448: Profiling the urinary bladder cancer composition and inter-cellular proximity patterns using single-cell RNA-sequencing and spatial transcriptomics." Cancer Research 85, no. 8_Supplement_1 (2025): 3448. https://doi.org/10.1158/1538-7445.am2025-3448.

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Abstract Urinary bladder cancer (UBC) has shown to be difficult to treat, attributed to tumor heterogeneity and differences in response to treatment based on molecular subtypes. It is essential that we increase our knowledge the interplay between the tumor, stroma and immune system to improve our knowledge of the TME in UBC and thereby therapeutic options. Herein we employed single-cell RNA sequencing and in situ spatial transcriptomics on bladder samples from two UBC mouse models (model development in PMID 34232958), including in-depth immune clustering to characterize the TME during tumor pr

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Steen, Chloe B., Bogdan A. Luca, Mohammad Shahrokh Esfahani, et al. "An Atlas of Clinically-Distinct Tumor Cellular Ecosystems in Diffuse Large B Cell Lymphoma." Blood 134, Supplement_1 (2019): 655. http://dx.doi.org/10.1182/blood-2019-129461.

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Background: Diffuse large B cell lymphoma (DLBCL) exhibits significant clinical and biological heterogeneity, in part due to cell-of-origin subtypes, somatic alterations, and diverse stromal constituents within the tumor microenvironment (TME). Several immunologically-active lymphoma therapies are known to rely on innate and adaptive anti-tumor responses occurring within this dynamic TME, including agents that are approved (e.g., rituximab, lenalidomide, CART19, ibrutinib) or emerging (e.g., anti-CD47, checkpoint inhibitors). We hypothesized that a large-scale characterization of the cellular

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Ruggeri, Loredana, Elena Urbani, Davide Chiasserini, et al. "Alloreactive Natural Killer Cells Initiate a Unique Cellular and Molecular Pathway That Greatly Accelerates Immune Reconstitution after Allogeneic Bone Marrow Transplantation." Blood 128, no. 22 (2016): 548. http://dx.doi.org/10.1182/blood.v128.22.548.548.

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Abstract One outstanding issue in allogeneic hematopoietic transplantation is impaired immune reconstitution. As the primary site of T cell development, the thymus plays a key role in the generation of a strong yet self-tolerant adaptive immune response, essential in the face of the potential threat from pathogens or neoplasia. Allogeneic hematopoietic transplantation may acutely damage the thymus through the chemo or radiotherapy, antibody therapy of the conditioning regime, infections acquired by the immunosuppressed patient, and thymic graft versus host disease. To date, attempts to improve

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Reimann, Christian, Andrea Schiavo, Julien Rouiller, et al. "Further Characterization of T-Cellular Precursors Generated From CD34+ Progenitors by Exposure to Immobilized Notch Ligand Delta-Like 4 In Vitro." Blood 116, no. 21 (2010): 3712. http://dx.doi.org/10.1182/blood.v116.21.3712.3712.

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Abstract Abstract 3712 Injection of donor derived T-cellular precursors has been proposed as a novel strategy to shorten delayed reconstitution of the T-lymphoid compartment following HSCT. In the past years, several research groups have successfully generated murine and human T-cellular precursors in vitro using Notchligand-based coculture systems such as OP9-DL1 or Tst-DL4. Murine T-cellular precursors generated in vitro, promoted reconstitution of the T-cellular compartment when applied in murine HSCT-models. In consistency, transfer of human T-cellular precursors, generated in vitro in coc

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Grenier, Julien, Barbara Peyrard, Auria Godard, et al. "New Insights into Cellular Defects during Haematopoiesis of Sickle Cell Disease Using the Townes Mouse Model." Blood 142, Supplement 1 (2023): 3855. http://dx.doi.org/10.1182/blood-2023-181742.

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Sickle cell disease (SCD) is an inherited disorder caused by a point mutation in the β globin gene leading to the synthesis of an abnormal haemoglobin (HbS), that under low oxygen tension polymerises driving the sickling of red blood cells and reducing their lifespan. SCD is characterized by anaemia, vaso-occlusion and haemolysis, progressive multiorgan damage and increased mortality. For decades, peripheral haemolysis has been considered as the sole driver of anaemia in SCD. Recently, we have demonstrated the occurrence of ineffective erythropoiesis (IE) in SCD suggesting that anaemia can be

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Palshikar, Mukta G., Maxwell Spurrell, Jack Demaray, et al. "Abstract 5492: Spatial organization and cellular composition of immunity hubs in human colorectal cancer." Cancer Research 84, no. 6_Supplement (2024): 5492. http://dx.doi.org/10.1158/1538-7445.am2024-5492.

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Abstract Background: Among colorectal cancer (CRC) tumors, mismatch repair deficient (MMRd) tumors have more immunogenic neo-antigens, hence more cytotoxic T-cell mediated anti-tumor immunity than mismatch repair proficient (MMRp) tumors. Previously1, we transcriptionally profiled over 300,000 cells from 62 MMRd and MMRp CRC tumors and found an MMRd-unique network of immunologically active transcriptional states enriched in interferon-stimulated genes (ISGs). With 4-color imaging, we showed that this program arises from spatially organized hubs of at least 3 cell types: IFNã-secreting T and in

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FitzPatrick, Michael E. B., Agne Antanaviciute, Melanie Dunstan, et al. "Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease." Nature Immunology, May 6, 2025. https://doi.org/10.1038/s41590-025-02146-2.

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Abstract The immune–epithelial–stromal interactions underpinning intestinal damage in celiac disease (CD) are incompletely understood. To address this, we performed single-cell transcriptomics (RNA sequencing; 86,442 immune, parenchymal and epithelial cells; 35 participants) and spatial transcriptomics (20 participants) on CD intestinal biopsy samples. Here we show that in CD, epithelial populations shifted toward a progenitor state, with interferon-driven transcriptional responses, and perturbation of secretory and enteroendocrine populations. Mucosal T cells showed numeric and functional cha

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Savino, Wilson, and Ailin Lepletier. "Thymus-derived hormonal and cellular control of cancer." Frontiers in Endocrinology 14 (July 17, 2023). http://dx.doi.org/10.3389/fendo.2023.1168186.

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The thymus gland is a central lymphoid organ in which developing T cell precursors, known as thymocytes, undergo differentiation into distinct type of mature T cells, ultimately migrating to the periphery where they exert specialized effector functions and orchestrate the immune responses against tumor cells, pathogens and self-antigens. The mechanisms supporting intrathymic T cell differentiation are pleiotropically regulated by thymic peptide hormones and cytokines produced by stromal cells in the thymic microenvironment and developing thymocytes. Interestingly, in the same way as T cells, t

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Stamatis, Pavlos, Carl Turesson, Despina Michailidou, and Aladdin J. Mohammad. "Pathogenesis of giant cell arteritis with focus on cellular populations." Frontiers in Medicine 9 (November 17, 2022). http://dx.doi.org/10.3389/fmed.2022.1058600.

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Giant cell arteritis (GCA), the most common non-infectious vasculitis, mainly affects elderly individuals. The disease usually affects the aorta and its main supra-aortic branches causing both general symptoms of inflammation and specific ischemic symptoms because of the limited blood flow due to arterial structural changes in the inflamed arteries. The pathogenesis of the GCA is complex and includes a dysregulated immune response that affects both the innate and the adaptive immunity. During the last two decades several studies have investigated interactions among antigen-presenting cells and

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MacFawn, Ian P., Grant Magnon, Grace Gorecki, et al. "The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions." Cancer Cell, October 2024. http://dx.doi.org/10.1016/j.ccell.2024.09.007.

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Thieme, Elana, Tingting Liu, Nur Bruss, et al. "Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma." Cell Death & Disease 13, no. 3 (2022). http://dx.doi.org/10.1038/s41419-022-04684-1.

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AbstractAberrant B-cell receptor (BCR) signaling is a key driver in lymphoid malignancies. Bruton tyrosine kinase (BTK) inhibitors that disrupt BCR signaling have received regulatory approvals in therapy of mantle cell lymphoma (MCL). However, responses are incomplete and patients who experience BTK inhibitor therapy failure have dire outcomes. CG-806 (luxeptinib) is a dual BTK/SYK inhibitor in clinical development in hematologic malignancies. Here we investigated the pre-clinical activity of CG-806 in MCL. In vitro treatment with CG-806 thwarted survival of MCL cell lines and patient-derived

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Santamaria Costa, X., R. Beatriz, K. Nanda, et al. "O-218 Single-cell RNA sequencing reveals that Ashermańs syndrome is caused by chronic inflammation that induces differential molecular and cellular cartography in the human endometrium." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac105.137.

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Abstract Study question What is the differential cellular, transcriptomic and immunological differences of the human endometrium in AS versus healthy patients at single cell resolution? Summary answer The epithelial fraction is decreased, the myeloid and lymphoid cell lineages increased with an altered inflammation, inhibition of angiogenesis and EM abnormal remodeling. What is known already Asherman’s Syndrome (AS) is an acquired pathological condition, defined by the presence of intrauterine adhesions (IUAs) causing the uterine walls to adhere to one another resulting in menstrual abnormalit

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García-Ceca, Javier, Sara Montero-Herradón, Ana González, Rosa Plaza, and Agustín G. Zapata. "Altered thymocyte development observed in EphA4-deficient mice courses with changes in both thymic epithelial and extracellular matrix organization." Cellular and Molecular Life Sciences 79, no. 11 (2022). http://dx.doi.org/10.1007/s00018-022-04610-w.

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AbstractEph receptors and their ligands, Ephrins, are involved in the thymocyte-thymic epithelial cell (TEC) interactions, key for the functional maturation of both thymocytes and thymic epithelium. Several years ago, we reported that the lack of EphA4, a Eph of the subfamily A, coursed with reduced proportions of double positive (DP) thymocytes apparently due to an altered thymic epithelial stroma [Munoz et al. in J Immunol 177:804–813, 2006]. In the present study, we reevaluate the lymphoid, epithelial, and extracellular matrix (ECM) phenotype of EphA4−/− mice grouped into three categories w

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