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Artigos de revistas sobre o tema "Composés antitumoraux"

Autor: Grafiati

Publicado: 19 de outubro de 2024

Última modificação: 31 de julho de 2025

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1

Romeiro, Camila Fernanda Rodrigues, Lucas Villar Pedrosa da Silva Pantoja, and Marcieni Ataíde de Andrade. "Compostos bioativos identificados em Ayapana triplinervis: Uma revisão sobre mecanismos antitumorais." Research, Society and Development 11, no. 6 (2022): e0811628478. http://dx.doi.org/10.33448/rsd-v11i6.28478.

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O câncer está entre as principais causas de morte no mundo. Disfunções mitocondriais – relacionadas a mutação ou não –, estresse oxidativo e ativação de células imunes se relacionam à fisiopatologia do câncer, em função da indução por múltiplas vias de fatores oncogênicos. Até o momento, a produção e o desenvolvimento de drogas antitumorais para o tratamento do câncer ainda se configura como uma barreira, até que a formulação esteja disponível em condições seguras aos pacientes. Nesse contexto, a abordagem com plantas de uso tradicional relatado, como a Ayapana triplinervis passou a chamar a a

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Sekaki, A., M. Gardès-Albert, C. Houée-Levin, et al. "Oxydation monoélectronique d’un composé antitumoral dérivé de l’ellipticine : le BD84." Journal de Chimie Physique 88 (1991): 977–85. http://dx.doi.org/10.1051/jcp/1991880977.

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Benazeth, S., D. Bazin, B. Viossat, H. Dexpert, P. Lamelle, and Nguyen-Huy Dung. "Composés du Pt(II) à visée antitumorale, dérivés de l’ellipticine et de ses analogues." Journal de Chimie Physique 86 (1989): 1635–42. http://dx.doi.org/10.1051/jcp/1989861635.

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Ferreira, Wagner Andrade, Gabriella Salles Aguiar, Heloisa Rodrigues Pessoa, Danielly Cristiny Ferraz da Costa, and Lilia Zago. "Potencial antitumoral dos compostos fenólicos de produtos da oliveira (Olea europaea L.): uma revisão integrativa da literatura." Research, Society and Development 10, no. 13 (2021): e22101320733. http://dx.doi.org/10.33448/rsd-v10i13.20733.

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Os compostos fenólicos de produtos da oliveira (Olea europaea L.) apresentam potencial antitumoral devido a prevenção da gênese e de supressão tumoral em diferentes modelos de câncer. Este artigo tem por objetivo realizar uma análise da literatura, por meio de uma revisão integrativa, sobre o potencial antitumoral dos compostos fenólicos dos produtos da oliveira. Trata-se de uma revisão integrativa da literatura, de caráter qualitativo e exploratório, baseada em estudos pré-clínicos, in vitro e in vivo, publicados em periódicos indexados em bases de dados que abordam a temática. A busca, sem r

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Bisanção, Vitória Roberto, Julio Cesar Polonio, and Halison Correia Golias. "COGUMELOS BASIDIOMYCOTA: FONTES DE COMPOSTOS COM ATIVIDADE ANTICÂNCER." Arquivos do Mudi 26, no. 2 (2022): 29–46. http://dx.doi.org/10.4025/arqmudi.v27i2.63571.

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Os cogumelos silvestres são fascinantes pela formação de seus corpos de frutificação e sua aplicação na indústria alimentícia e medicinal, apresentando-se como uma grande fonte de extração de metabólitos secundários com propriedades farmacológicas. Esta revisão tem como objetivo fornecer informações sobre a produção de compostos com atividade anticancerígena por cogumelos do filo Basidiomycota, apresentando diferentes moléculas obtidas desses organismos e como elas atuam no combate às células tumorais. Dentre os principais medicamentos produzidos a partir desses fungos, destacam-se os utilizad

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Araújo, Romaína Idayara Silva de, Carolinne Maia Melo, Diana França da Silva, et al. "Efeito dos compostos bioativos da Eleutherine plicata e suas propriedades medicinais: uma revisão de literatura." REVISTA DELOS 18, no. 69 (2025): e5811. https://doi.org/10.55905/rdelosv18.n69-040.

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O presente estudo trata-se de uma revisão sistemática da literatura, com o objetivo de retratar a importância da espécie E. plicata e seus compostos bioativos, oferecendo uma visão abrangente do estado atual de pesquisas relacionadas a temática em questão. Os estudos selecionados evidenciaram que a Eleutherine plicata apresenta um conjunto de compostos bioativos, com destaque para as naftoquinonas eleuterina, isoleuterina e eleuterol, que desempenham diferentes ações farmacológicas. Estudos in vitro demonstraram a capacidade desses compostos em inibir o crescimento de células tumorais, inclusi

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Cristina Novaes dos Reis, Roberta, Gustavo Alves de Castro, Gustavo Henrique Souza Oliveira, et al. "Potenciais aplicações medicinais de compostos 1,2,3-triazólicos: uma revisão." HU Revista 48 (August 11, 2022): 1–15. http://dx.doi.org/10.34019/1982-8047.2022.v48.36662.

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Introdução: Os 1,2,3-triazóis são compostos de origem sintética e são relevantes para a química medicinal, além de poderem atuar como uma conexão entre duas ou mais substâncias de interesse, em uma estratégia de hibridação molecular. Objetivo: Abordar algumas aplicações farmacológicas dos derivados 1,2,3-triazólicos. Material e Métodos: Uma busca na base de dados Scopus utilizando o termo “1,2,3 triazole” (janeiro de 2021), foi realizada, além de uma pesquisa nos bancos de dados eletrônicos público. Resultados: Foram encontrados 5.760 resultados para os últimos dez anos sobre 1,2,3-triazóis, b

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Santos, Viviane Martins Rebello dos, Claudio Luis Donnici, João Batista Neves DaCosta, and Janaína Marques Rodrigues Caixeiro. "Compostos organofosforados pentavalentes: histórico, métodos sintéticos de preparação e aplicações como inseticidas e agentes antitumorais." Química Nova 30, no. 1 (2007): 159–70. http://dx.doi.org/10.1590/s0100-40422007000100028.

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Scheller, S., W. Krol, K. Skirmuntt, G. Zydowicz, and J. Shani. "Antitumoral Effect of Bleomycin + Dolomite Combination Treatment, in Mice Bearing Ehrlich Ascites Carcinoma." Zeitschrift für Naturforschung C 48, no. 9-10 (1993): 818–20. http://dx.doi.org/10.1515/znc-1993-9-1023.

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Abstract Dolomite, a mineral composed of magnesium and calcium carbonates, potentiates the antitumoral activity of bleomycin: While 40 days after inoculation, no mice survived the Ehrlich ascites tumor burden, 44% of them survived it after bleomycin treatment, and 63% after a simultaneous treatment of bleomycin and dolomite. The beneficial antitumor effect of dolomite is probably related to its high content (12.8%) of magnesium

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Oliveira, Bruno Hanrry Melo, Luiz André Araujo Silva, Fernando Ferreira Leite, et al. "Síntese e avaliação antitumoral do (±)-4-O-demethylKadsurenin M um composto natural e seus análogos." Brazilian Journal of Development 5, no. 10 (2019): 19109–23. http://dx.doi.org/10.34117/bjdv5n10-144.

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Bouyahya, A., J. Abrini, Y. Bakri, and N. Dakka. "Les huiles essentielles comme agents anticancéreux : actualité sur le mode d’action." Phytothérapie 16, no. 5 (2018): 254–67. http://dx.doi.org/10.3166/s10298-016-1058-z.

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Le cancer est une maladie complexe qui présente un réel problème de santé publique à travers le monde et cause statiquement sept millions de décès chaque année. Au cours des dernières décennies, la thérapie anticancéreuse a connu un réel bouleversement et un foisonnement de découvertes fondamentales. Plusieurs études accumulatives ont révélé l’activité antitumorale des substances naturelles isolées à partir de plantes. Les huiles essentielles (HE) et leurs constituants ont montré des activités anticancéreuses puissantes in vitro et in vivo. Cependant, les mécanismes d’action sont encore peu ét

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da Silva, Tereza Cristina, Bruno Cogliati, Andréia Oliveira Latorre, et al. "Pfaffosidic Fraction fromHebanthe paniculataInduces Cell Cycle Arrest and Caspase-3-Induced Apoptosis in HepG2 Cells." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/835796.

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Hebanthe paniculataroots (formerlyPfaffia paniculataand popularly known as Brazilian ginseng) show antineoplastic, chemopreventive, and antiproliferative properties. Functional properties of these roots and their extracts are usually attributed to the pfaffosidic fraction, which is composed mainly by pfaffosides A–F. However, the therapeutic potential of this fraction in cancer cells is not yet entirely understood. This study aimed to analyze the antitumoral effects of the purified pfaffosidic fraction or saponinic fraction on the human hepatocellular carcinoma HepG2 cell line. Cellular viabil

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Nogueira, Camila Castencio, Alice Pereira Lourenson, Maicon da Silva Lacerda, and Márcia Arocha Gularte. "Folhas de oliveira secas e in natura: comparação de suas propriedades e compostos bioativos." REVISTA DELOS 18, no. 65 (2025): e4357. https://doi.org/10.55905/rdelosv18.n65-056.

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Os subprodutos provenientes da oliveira são ricos em compostos bioativos, apresentam efeito antitumoral, anti-inflamatórios e atividade antimicrobiana. Sua aplicação na indústria pode ser significativa devido à gama de produtos que estes compostos podem fazer parte. Nesse sentido, o estudo comparou as propriedades e compostos bioativos de folhas de oliveira secas (FS) e in natura (FN), com o objetivo de avaliar o impacto do processo de secagem na preservação de seus constituintes funcionais. Foram analisados parâmetros como teor de compostos fenólicos totais, flavonoides, carotenoides, clorofi

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Iosub, Gheorghe, Dana-Ionela Tudorache (Trifa), Ionuț Marinel Iova, et al. "Bioactive Hydroxyapatite–Carboplatin–Quercetin Coatings for Enhanced Osteointegration and Antitumoral Protection in Hip Endoprostheses." Coatings 15, no. 4 (2025): 489. https://doi.org/10.3390/coatings15040489.

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The recurrence of bone cancer poses severe complications, particularly after orthopedic surgery, necessitating advanced biomaterials with dual functionality. This study develops nanostructured coatings composed of hydroxyapatite, carboplatin, and quercetin, designed to enhance bone regeneration while delivering localized cancer therapy. These coatings present a promising solution for hip endoprostheses, addressing osteointegration and tumor recurrence prevention simultaneously. Hydroxyapatite was synthesized and characterized using XRD, TEM, SAED, FTIR, and SEM to assess crystallinity, surface

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Mojsilovic, Sonja S., Slavko Mojsilovic, Victor H. Villar, and Juan F. Santibanez. "The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy?" Analytical Cellular Pathology 2021 (August 14, 2021): 1–12. http://dx.doi.org/10.1155/2021/5523055.

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Besides transformed cells, the tumors are composed of various cell types that contribute to undesirable tumor progression. Tumor-associated macrophages (TAMs) are the most abundant innate immune cells in the tumor microenvironment (TME). Within the TME, TAMs exhibit high plasticity and undergo specific functional metabolic alterations according to the availability of tumor tissue oxygen and nutrients, thus further contributing to tumorigenesis and cancer progression. Here, we review the main functional TAM metabolic patterns influenced by TME, including glycolysis, amino acid, and fatty acid m

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Formaggio, Daniela M. D., Jéssica A. Magalhães, Vitor M. Andrade, et al. "Co-Functionalization of Gold Nanoparticles with C7H2 and HuAL1 Peptides: Enhanced Antimicrobial and Antitumoral Activities." Pharmaceutics 14, no. 7 (2022): 1324. http://dx.doi.org/10.3390/pharmaceutics14071324.

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The functionalization of nanoparticles with therapeutic peptides has been pointed out as a promising strategy to improve the applications of these molecules in the field of health sciences. Peptides are highly bioactive but face several limitations such as low bioavailability due to the difficulty of overcoming the physiological barriers in the body and their degradation by enzymes. In this work, gold nanoparticles (AuNPs) were co-functionalized with two therapeutic peptides simultaneously. The peptides from the complementary determining region of monoclonal antibodies, composed of the amino a

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Vedeanu, Nicoleta Simona, Cristian Lujerdean, Marius Zăhan, et al. "Synthesis and Structural Characterization of CaO-P2O5-CaF:CuO Glasses with Antitumoral Effect on Skin Cancer Cells." Materials 15, no. 4 (2022): 1526. http://dx.doi.org/10.3390/ma15041526.

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Copper is one of the most used therapeutic metallic elements in biomedicine, ranging from antibacterial approaches to developing new complexes in cancer therapy. In the present investigation, we developed a novel xCuO∙(100 − x) [CaF2∙3P2O5∙CaO] glass system with 0 ≤ x ≤ 16 mol% in order to determine the influence of doping on the composition structure of glasses. The samples were characterized by dissolution tests, pH measurements, Fourier-transform infrared spectroscopy (FT-IR), electron paramagnetic resonance (EPR), Scanning Electron Microscopy with energy dispersive spectroscopy (SEM-EDX) a

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Moreira, João de Brito, Naíra Assunção De Sá Holanda, Sarah Raquel Silveira Da Silva Santiago, et al. "LEVANTAMENTO BIBLIOGRÁFICO DOS COMPOSTOS QUÍMICOS COM ATIVIDADE ANTIOXIDANTE E ANTIMICROBIANA PRESENSTES EM Arrabidaea chica (HUMB. & BONPL.) B. VERLOT (BIGNONIACEAE)." REVISTA FOCO 17, no. 1 (2024): e4141. http://dx.doi.org/10.54751/revistafoco.v17n1-073.

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A espécie vegetal Arrabidaea chica, popularmente como pariri, cipó-pau ou crajiru, destaca-se por suas diversas propriedades medicinais. Dentre elas, a possibilidade de uso no tratamento de inflamações uterinas, sífilis, leucemia, conjuntivites, diarreias, cólicas intestinais, psoríase, impigens, úlceras, prevenção contra cáries dentre outros. Apesar de ser um organismo amplamente estudado, o número de monografias, dissertações, teses e artigos que abordam essa espécie nos últimos dez anos não ultrapassa cinquenta e cinco, e essa quantidade é ainda menor no Amazonas. Nesse contexto, este estud

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Nunes, Higor Lopes, Katiuska Tuttis, Juliana Mara Serpeloni, Cláudia Quintino da Rocha, and Ilce Mara de Syllos Cólus. "Efeito necrótico de brachydin A, um composto de origem vegetal, em células humanas de próstata normais e tumorais." Semina: Ciências Biológicas e da Saúde 38, no. 1supl (2018): 158. http://dx.doi.org/10.5433/1679-0367.2017v38n1suplp158.

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Para combater efeitos genotóxicos de agentes químicos, aditivos de alimentos e medicamentos que causam danos no DNA, estudos sobre quimioprevenção são desenvolvidos com o propósito de reverter ou suprimir lesões pré-malignas ou malignas por meio da utilização de compostos químicos naturais ou sintéticos. Os fitoterápicos têm sido uma alternativa para quimioprevenção de doenças crônicas. Entre as plantas utilizadas na medicina popular brasileira destaca-se o gênero Arrabidaea (família Bignoniaceae). Diversas espécies deste gênero têm sido utilizadas na medicina tradicional com função antioxidan

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Lucas, Mariana, Marisa Freitas, Artur M. S. Silva, Eduarda Fernandes, and Daniela Ribeiro. "Styrylchromones: Biological Activities and Structure-Activity Relationship." Oxidative Medicine and Cellular Longevity 2021 (December 22, 2021): 1–47. http://dx.doi.org/10.1155/2021/2804521.

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Styrylchromones (SC) are a group of oxygen-containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the chromone core. SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is the most common. Two types of SC are known: 2-styrylchromones and 3-styrylchromones. However, 2-styrylchromones are the most common, being more commonly found in nature and which chemical synthesis is more commonly described. A wide variety of SC has been described in the literature, with different

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Pieretti, Joana C., Jordan Beurton, Julián Munevar, et al. "The Impact of Multiple Functional Layers in the Structure of Magnetic Nanoparticles and Their Influence on Albumin Interaction." International Journal of Molecular Sciences 22, no. 19 (2021): 10477. http://dx.doi.org/10.3390/ijms221910477.

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In nanomedicine, hybrid nanomaterials stand out for providing new insights in both the diagnosis and treatment of several diseases. Once administered, engineered nanoparticles (NPs) interact with biological molecules, and the nature of this interaction might directly interfere with the biological fate and action of the NPs. In this work, we synthesized a hybrid magnetic nanostructure, with antibacterial and antitumoral potential applications, composed of a magnetite core covered by silver NPs, and coated with a modified chitosan polymer. As magnetite NPs readily oxidize to maghemite, we invest

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Solano, Alfredo Amaury Bautista, Gloria Dávila-Ortiz, María de Jesús Perea-Flores, and Alma Leticia Martínez-Ayala. "Optimization and Synthesis of Nano-Niosomes for Encapsulation of Triacontanol by Box–Behnken Design." Molecules 29, no. 18 (2024): 4421. http://dx.doi.org/10.3390/molecules29184421.

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Triacontanol is a long-chain primary alcohol derived from policosanol, known for its diverse biological activities, including functioning as a plant growth regulator and exhibiting anti-inflammatory and antitumoral effects. However, its application is limited due to its high hydrophobicity, resulting in poor absorption and reduced therapeutic effectiveness. A potential solution to this problem is the use of niosomes. Niosomes are carriers composed of non-ionic surfactants, cholesterol, charge-inducing agents, and a hydration medium. They are effective in encapsulating drugs, improving their so

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Paíno, Teresa, Antonio Garcia-Gomez, Lorena González-Méndez, et al. "Dual Antitumoral and Bone Antiresorptive Effect Of The Pan-Pim Kinase Inhibitor, LGH447, In Multiple Myeloma." Blood 122, no. 21 (2013): 4435. http://dx.doi.org/10.1182/blood.v122.21.4435.4435.

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Introduction Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow (BM) and is closely associated with osteolytic lesions, in part due to an increase in the bone-resorptive activity and number of osteoclasts (OCs). The activation of survival pathways in myeloma cells could be the cause of treatment failure rendering the disease incurable. Pim kinases are a family of survival serine/threonine kinases composed of three members (Pim1, Pim2 and Pim3) that are overexpressed in MM cells and may have a role in MM pathogenesis. However, little is known

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Corrêa, Anna, Mauricio Vericimo, Andriy Dashevskiy, Patricia Pereira, and Vania Paschoalin. "Liposomal Taro Lectin Nanocapsules Control Human Glioblastoma and Mammary Adenocarcinoma Cell Proliferation." Molecules 24, no. 3 (2019): 471. http://dx.doi.org/10.3390/molecules24030471.

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The search for natural anticancer agents and nanocarrier uses are a part of the current strategies to overcome the side effects caused by chemotherapeutics. Liposomal nanocapsules loaded with purified tarin, a potential immunomodulatory and antitumoral lectin found in taro corms, were produced. Liposomes were composed by 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine, cholesterylhemisuccinate, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000 prepared by thin-film hydration. Small unilamellar vesicles were achieved by sonication and extrusion. Scanning ele

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Yang, Haijun, Xiang Li, Ning Zhang, Qingqi Zeng, Qiping Yu, and Shihuai Ke. "HPLC Method for the Simultaneous Determination of Ten Annonaceous Acetogenins after Supercritical Fluid CO2 Extraction." International Journal of Biomedical Science 6, no. 3 (2010): 202–7. http://dx.doi.org/10.59566/ijbs.2010.6202.

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Annonaceous acetogenins (ACGs) isolated from Annonaceaeplants exhibited a broad range of biological bioactivities such as cytotoxic, antitumoral, antiparasitic, pesticidal and immunosuppresive activities. However, their structures were liable to change at more than 60°C and their extraction yields were low using traditional organic solvent extraction. In the present study, all samples from Annona genus plant seeds were extracted by supercritical carbon dioxide under optimized conditions and a high-performance liquid chromatography (HPLC) method was established for simultaneously determining te

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Yu, Chunxiao, Kurt Shanebeck, Shiguang Yu, et al. "Abstract 2474: Antitumoral efficacy of ASKG812, a Smartkine® based bifunctional PD-1-eIL-2 molecule, through enhancing T effector cis agonism." Cancer Research 84, no. 6_Supplement (2024): 2474. http://dx.doi.org/10.1158/1538-7445.am2024-2474.

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Abstract Cytokines are potent molecules, yet their broad application as therapeutics has been significantly hampered due to short PK, severe systemic toxicity, and narrow therapeutic window. To improve the developability of cytokines, AskGene has invented a proprietary cytokine platform (Smartkine®) to achieve its overarching objective of modulating immune reactions at a disease site in a selective and controlled manner. Several antibody-cytokine fusion molecules using the SmartKine® platform have been moving into preclinical and clinical development. ASKG812 is a unique fusion molecule compos

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Sosa-Lochedino, Arianna, María Belén Hapon, and Carlos Gamarra-Luques. "A Systematic Review About the Contribution of The Genus Tessaria (Asteraceae) To Cancer Study and Treatment." Uniciencia 36, no. 1 (2022): 1–17. http://dx.doi.org/10.15359/ru.36-1.30.

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Belonging to the Asteraceae family, Tessaria (Ruiz & Pavon, 1753) is a genus of shrubs or small trees distributed in various habitats located from Argentina to the southwestern United States of America. The taxa are composed of five confirmed species, which have been previously reported for their ethnopharmacological uses as hypocholesterolemiant, hypoglycemic, antitussive, anti-inflammatory, anticancer, and abortifacient agent; it also has been used in hepatic, renal, pulmonary, and rheumatic diseases. Up to the present, T. absinthioides, T. ambigua, T. dodoneifolia, T. fastigiata and T.

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Moya-Lopez, Carmen, Alberto Juan, Murillo Donizeti, et al. "Multifunctional PLA/Gelatin Bionanocomposites for Tailored Drug Delivery Systems." Pharmaceutics 14, no. 6 (2022): 1138. http://dx.doi.org/10.3390/pharmaceutics14061138.

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A series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles featuring different nanostructures were designed to generate multifunctional drug delivery systems with tailored release rates required for personalized treatment approaches. The global conception of the systems was considered from the desired customization of the drug release while featuring the viscoelastic properties needed for their ease of storage and posterior local administration as well as their biocompatibility and cell growth capability for the successful administration at the biomolecular level.

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Sosa, A., M. Hapon, and C. Gamarra. "A Systematic Review About the Contribution of The Genus Tessaria (Asteraceae) To Cancer Study and Treatment." Uniciencia 36, no. 1 (2022): 1–17. https://doi.org/10.15359/ru.36-1.30.

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Abstract Belonging to the Asteraceae family, Tessaria (Ruiz & Pavon, 1753) is a genus of shrubs or small trees distributed in various habitats located from Argentina to the southwestern United States of America. The taxa are composed of five confirmed species, which have been previously reported for their ethnopharmacological uses as hypocholesterolemiant, hypoglycemic, antitussive, anti-inflammatory, anticancer, and abortifacient agent; it also has been used in hepatic, renal, pulmonary, and rheumatic diseases. Up to the present, T. absinthioides, T. ambigua, T. d

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Dieu-Nosjean, Marie-Caroline, Martine Antoine, Claire Danel, et al. "Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid Structures." Journal of Clinical Oncology 26, no. 27 (2008): 4410–17. http://dx.doi.org/10.1200/jco.2007.15.0284.

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Purpose It has been established that the immune system plays an important role in tumor rejection. There is also compelling evidence that immune responses can develop independently of secondary lymphoid organs in tertiary lymphoid structures. We studied the presence and the correlation of tertiary lymphoid structures with clinical outcome in non–small-cell lung cancer (NSCLC), as the prognostic value of these structures in patients with cancer had not yet been established. Patients and Methods This retrospective study was performed by immunohistochemistry on paraffin-embedded tissue specimens

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Frapolli, Roberta, Ezia Bello, Marina Meroni, et al. "Abstract 315: Dose-response and tumor size at time of treatment with TD001, a novel ADC against PSMA, drive potent tumor growth inhibition in a CRPC CDX castrated mouse model." Cancer Research 85, no. 8_Supplement_1 (2025): 315. https://doi.org/10.1158/1538-7445.am2025-315.

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Abstract Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein belonging to the folate receptor family, is highly expressed in metastatic castrate-resistant prostate cancer (CRPC), and increases following androgen deprivation therapy. TD001 is a novel antibody-drug conjugate (ADC) composed of a deimmunized anti-PSMA IgG1 monoclonal antibody (HuJ591), which binds to the extracellular domain of PSMA, conjugated to a proprietary cleavable topoisomerase I inhibitor exatecan linker-payload (LD038), with a drug-to-antibody ratio (DAR) of 8. Flow cytometry and immunofluoresc

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Bessede, Thomas, Clara Freixinos, Jennifer Barrat, et al. "Abstract B045: Sensitizing the PDAC tumor microenvironment to immune checkpoint therapies: characterization of a PDAC 3D model to decipher immune infiltration." Cancer Research 84, no. 17_Supplement_2 (2024): B045. http://dx.doi.org/10.1158/1538-7445.pancreatic24-b045.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal solid tumor with an unfavorable prognosis, often resistant to conventional treatments due to its dense stroma rich in Cancer- Associated Fibroblasts (CAFs). Limited T cell infiltration and prevalence of immunosuppressive cells within the tumor hinder the efficacy of immune checkpoint inhibitors (ICIs). The objective of our project is to modify immune landscape of PDAC tumor microenvironment (TME) to induce ICIs sensitization. We thus develop novel therapeutic strategies combining an immunomodulatory cytokine Interleukine-15 (I

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Bessede, Thomas, Clara Freixinos, Jennifer Barrat, et al. "Abstract B046: Sensitizing the PDAC tumor microenvironment to immune checkpoint therapies: characterization of a PDAC 3D model to decipher immune infiltration." Cancer Research 84, no. 17_Supplement_2 (2024): B046. http://dx.doi.org/10.1158/1538-7445.pancreatic24-b046.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal solid tumor with an unfavorable prognosis, often resistant to conventional treatments due to its dense stroma rich in Cancer- Associated Fibroblasts (CAFs). Limited T cell infiltration and prevalence of immunosuppressive cells within the tumor hinder the efficacy of immune checkpoint inhibitors (ICIs). The objective of our project is to modify immune landscape of PDAC tumor microenvironment (TME) to induce ICIs sensitization. We thus develop novel therapeutic strategies combining an immunomodulatory cytokine Interleukine-15 (I

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Pattarini, Lucia, Marina Pavlidou, Aizea Kastresana Morales, et al. "Abstract LB220: The anticalin-antibody bispecific PRS-352/S095025 strongly stimulates human CD4+ T cells in a PD-L1-dependent manner." Cancer Research 82, no. 12_Supplement (2022): LB220. http://dx.doi.org/10.1158/1538-7445.am2022-lb220.

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Abstract Background: OX40, a member of the tumor necrosis factor receptor superfamily, is a costimulatory molecule promoting survival and cytokine release by effector T cells and inhibiting human regulatory T-cell activity. OX40 activation has been explored as a potential treatment for solid malignancies, using mainly agonistic anti-OX40 antibodies. These antibodies rely on Fc gamma receptor (FcγR)-mediated crosslinking to activate the OX40 pathway and have shown so far only limited antitumoral efficacy in clinical settings. One underlying hypothesis is that FcγR crosslinking of these antibodi

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Lenz, Heinz-Josef, Thibaud Koessler, Paul Oberstein, et al. "Abstract CT570: KISIMA-01: A first-in-human trial of the heterologous prime-boost vaccine ATP128/VSV-GP128 with ezabenlimab (BI 754091) in patients with stage IV colorectal cancer." Cancer Research 82, no. 12_Supplement (2022): CT570. http://dx.doi.org/10.1158/1538-7445.am2022-ct570.

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Abstract Background: Most microsatellite stable/mismatch repair proficient (MSS/MMRp) stage IV colorectal cancers (CRC) do not respond to PD-1 inhibition. ATP128, based on the KISIMA platform, is a single chimeric fusion protein, composed of 3 elements essential to generate potent antitumoral cellular immunity: a proprietary cell-penetrating peptide (CPP) for antigen delivery, a proprietary Toll-like receptor (TLR)-peptide agonist with self-adjuvant properties and a modulable multi-antigenic domain (Mad), where the Mad for CRC includes 3 antigens: carcinoembryonic antigen (CEA), Survivin, Acha

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Spriano, Filippo, Alberto J. Arribas, Nikolai Bendik, et al. "Abstract 611: Actinobacteria from macroalgae as a source of new anti-lymphoma compounds." Cancer Research 85, no. 8_Supplement_1 (2025): 611. https://doi.org/10.1158/1538-7445.am2025-611.

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Abstract Background: Actinomycetota of the genus Streptomyces are well known to produce a wide range of secondary metabolites, many of which have already been developed into antibiotics, antifungals, anti-inflammatory compounds, and anticancer agents. They can be found in the marine environment, including the deep sea, and are frequently associated with marine organisms, such as macroalgae. We studied the anti-lymphoma activity of extracts from Actinomycetota isolated from several deep-sea samples and macroalgae species abundant along the Portuguese coast. Methods: Organic extracts were made f

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Skov, Vibe, Thomas Stauffer Larsen, Mads Thomassen, et al. "Increased Expression of Proteasome-Related Genes In Patients with Primary Myelofibrosis." Blood 116, no. 21 (2010): 4117. http://dx.doi.org/10.1182/blood.v116.21.4117.4117.

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Abstract Abstract 4117 Introduction: The proteasome is an ubiquituous enzyme complex that plays a critical role in the degradation of many proteins involved in cell cycle regulation, apoptosis, and angiogenesis. Since these pathways and functions are often deregulated in cancer cells, inhibition of the proteasome is an attractive potential anticancer therapy. Bortezomib (Velcade, formerly PS-341) is an extremely potent and selective proteasome inhibitor that shows strong activity against many solid and hematologic tumor types. Moreover, bortezomib, mainly by inhibition of the NF-kappaB pathway

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Silva, Mariane. "O promissor potencial dos compostos canabinóides no tratamento ao câncer." Ensaios USF 7, no. 1 (2023). http://dx.doi.org/10.24933/e-usf.v7i1.232.

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Este trabalho teve como principal objetivo despertar o interesse na busca de novas alternativas de tratamento para os mais variados tipos de câncer, considerando o grande volume de acometimentos desta doença em âmbito mundial, e pelo alto grau de letalidade que ela acarreta. Como os tratamentos convencionais não vêm alcançando resultados desejados na maior parte da população diagnosticada, pois impõem manifestações físicas adversas severas aos pacientes e em determinados tipos de tumores não são capazes de interromper o processo de proliferação do câncer, por estas razões, novas opções de tera

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Cavararo, Carollyne Dos Santos, Jorge Pinho Silva Jr, Josiane Roberto Domingues, and Claudete Corrêa de Jesus Chiappini. "DESENVOLVIMENTO E ACEITAÇÃO SENSORIAL DE KEFIR COM GELEIA DE GOIABA E AVALIAÇÃO DE COMPOSTOS BIOATIVOS." DEMETRA: Alimentação, Nutrição & Saúde 13, no. 2 (2018). http://dx.doi.org/10.12957/demetra.2018.31290.

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Introdução: Compostos bioativos são definidos como nutrientes ou não nutrientes que possuem ação metabólica ou fisiológica específica no organismo, como as ações antitumoral, antifúngica, antibacteriana, imunomoduladora, anti-inflamatória e antioxidante. Os probióticos presentes nos leites fermentados e os carotenoides presentes nas frutas são descritos, na literatura, como benéficos à saúde. Objetivo: Desenvolver, avaliar a aceitação sensorial, a atividade antioxidante e determinados compostos bioativos de kefir com geleia de goiaba. Metodologia: O kefir foi desenvolvido e sua aceitação avali

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Lucas, Mariana, Marisa Freitas, Artur M. S. Silva, Eduarda Fernandes, and Daniela Ribeiro. "Styrylchromones: Biological Activities and Structure‐Activity Relationship." ChemMedChem, October 31, 2024. http://dx.doi.org/10.1002/cmdc.202400782.

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Styrylchromones (SC) are a group of oxygen‐containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the chromone core. SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is the most common. Two types of SC are known: 2‐styrylchromones and 3‐styrylchromones. However, 2‐styrylchromones are the most common, being more commonly found in nature and which chemical synthesis is more commonly described. A wide variety of SC has been described in the literature, with different

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Xue, Wenjing, Caili Xu, Kaiqi Zhang, et al. "Enhancing antitumor efficacy of CLDN18.2-directed antibody-drug conjugates through autophagy inhibition in gastric cancer." Cell Death Discovery 10, no. 1 (2024). http://dx.doi.org/10.1038/s41420-024-02167-0.

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AbstractClaudin18.2 (CLDN18.2) is overexpressed in cancers of the digestive system, rendering it an ideal drug target for antibody-drug conjugates (ADCs). Despite many CLDN18.2-directed ADCs undergoing clinical trials, the inconclusive underlying mechanisms pose a hurdle to extending the utility of these agents. In our study, αCLDN18.2-MMAE, an ADC composed of an anti-CLDN18.2 monoclonal antibody and the tubulin inhibitor MMAE, induced a dose-dependent apoptosis via the cleavage of caspase-9/PARP proteins in CLDN18.2-positive gastric cancer cells. It was worth noting that autophagy was remarka

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Dobaño-López, Cèlia, Juan García Valero, Ferran Araujo-Ayala, et al. "Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target." Blood Cancer Journal 14, no. 1 (2024). http://dx.doi.org/10.1038/s41408-024-01041-7.

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AbstractFollicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we present the first FL-Patient Derived Lymphoma Spheroid (FL-PDLS), including fundamental immune actors and features of TME in FL lymph nodes (LNs). FL-PDLS is organized in disc-shaped 3D structures composed of proliferating B and T cells, together with macrophages with an intermediate M1/M2 phenotype. FL-PDLS recapitulates the most relevant B-cell transcriptional pathw

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Gremski, Luiza Helena, Fernando Hitomi Matsubara, Nayanne Louise Costacurta Polli, et al. "Prospective Use of Brown Spider Venom Toxins as Therapeutic and Biotechnological Inputs." Frontiers in Molecular Biosciences 8 (June 17, 2021). http://dx.doi.org/10.3389/fmolb.2021.706704.

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Brown spider (genus Loxosceles) venoms are mainly composed of protein toxins used for predation and defense. Bites of these spiders most commonly produce a local dermonecrotic lesion with gravitational spread, edema and hemorrhage, which together are defined as cutaneous loxoscelism. Systemic loxoscelism, such as hematological abnormalities and renal injury, are less frequent but more lethal. Some Loxosceles venom toxins have already been isolated and extensively studied, such as phospholipases D (PLDs), which have been recombinantly expressed and were proven to reproduce toxic activities asso

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Matos, Aline da Rocha, Braulia Costa Caetano, João Luiz de Almeida Filho, et al. "Identification of Hypericin as a Candidate Repurposed Therapeutic Agent for COVID-19 and Its Potential Anti-SARS-CoV-2 Activity." Frontiers in Microbiology 13 (February 10, 2022). http://dx.doi.org/10.3389/fmicb.2022.828984.

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The COVID-19 pandemic has had an unprecedented impact on the global economy and public health. Its etiologic agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible, pathogenic and has a rapid global spread. Currently, the increase in the number of new confirmed cases has been slowed down due to the increase of vaccination in some regions of the world. Still, the rise of new variants has influenced the detection of additional waves of rising cases that some countries have experienced. Since the virus replication cycle is composed of many distinct stages,

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Rosato, Francesca, Rajeev Pasupuleti, Jana Tomisch, et al. "A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death." Journal of Translational Medicine 20, no. 1 (2022). http://dx.doi.org/10.1186/s12967-022-03794-w.

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Abstract Background Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids on cell surfaces and represent potential tools for application in cancer diagnostics and therapy. Among the emerging cancer therapies, immunotherapy has become a promising treatment modality for various hematological and solid malignancies. Here we present an approach to redirect the immune system into fighting cancer by targeting altered glycans at the surface of malig

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Carbone, Maria Luigia, Alessia Capone, Marika Guercio, et al. "Insight into immune profile associated with vitiligo onset and anti-tumoral response in melanoma patients receiving anti-PD-1 immunotherapy." Frontiers in Immunology 14 (August 23, 2023). http://dx.doi.org/10.3389/fimmu.2023.1197630.

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IntroductionImmunotherapy with checkpoint inhibitors is an efficient treatment for metastatic melanoma. Development of vitiligo upon immunotherapy represents a specific immune-related adverse event (irAE) diagnosed in 15% of patients and associated with a positive clinical response. Therefore, a detailed characterization of immune cells during vitiligo onset in melanoma patients would give insight into the immune mechanisms mediating both the irAE and the anti-tumor response. MethodsTo better understand these aspects, we analyzed T cell subsets from peripheral blood of metastatic melanoma pati

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