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Artigos de revistas sobre o tema "Controlled and sustained release"

Autor: Grafiati

Publicado: 7 de junho de 2025

Última modificação: 2 de agosto de 2025

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1

Gauthier, Serge, and Donna Amyot. "Sustained Release Antiparkinson Agents: Controlled Release Levodopa." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 19, S1 (1992): 153–55. http://dx.doi.org/10.1017/s0317167100041548.

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ABSTRACT:The rationale for sustained release oral levodopa preparations is to deliver levodopa in the areas of maximal intestinal absorption in a slow and predictable way, leading to stable plasma levodopa levels and brain dopamine levels, therefore resulting in a lengthened duration of action. Sinemet CR is the prototype of such preparations, with demonstrated efficacy in decreasing periods of akinesia in parkinsonian patients with mild to moderate motor fluctuations. Total doses of levodopa are raised 10 to 30% because of the lowered bioavailability; diphasic dyskinesias may increase at the

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Kumar, Deepak, ,. Archana, and Abadhesh Kumar Niranjan. "A Comprehensive Review on Sustained Release Matrix Drug Delivery System." Journal of Drug Delivery and Therapeutics 12, no. 4-S (2022): 249–53. http://dx.doi.org/10.22270/jddt.v12i4-s.5540.

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Formulations for sustained medication release are very useful in the treatment of chronic disorders. The oral route has selected matrix tablets as the most likely type of prolonged drug release. In order to generate therapeutic activity for a protracted duration, matrix tablets maintain a stable plasma drug concentration and sustain the rate of release of the drug throughout time. In preparations with a short half-life and high dosage frequency, extended-release is crucial. The matrix regulates how quickly the medication is released. Retardants such polyglycolic acid, polymethyl methacrylate,

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Kalyani Shelar, Gauri Mahajan, Nikita Pagare, Prachiti Sahane, and Sakshi Bhosale. "Review on Sustained Release Tablet." International Journal of Scientific Research in Science and Technology 11, no. 6 (2024): 698–708. https://doi.org/10.32628/ijsrst241161126.

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This review highlights the advantages of SR formulations, including reduced side effects, enhanced drug utilization, improved treatment efficacy, and better patient compliance. Key considerations for developing sustained release tablet involve the drug's physicochemical properties and biological factors, such as absorption and metabolism. Various formulation strategies, including diffusion-controlled, dissolution-controlled, and osmotic systems, are discussed alongside essential evaluation parameters like density, hardness, and in-vitro drug release profiles. The outlook for sustained release

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Addanki, Anusha, Ponnekanti Krishnaphanisri, Tiwari Ramanuj, Swapna L., Mabrur Hussain Md, and Siddhardha A. "A review of medicines with sustained release." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 221–33. https://doi.org/10.5281/zenodo.8036007.

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Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties for maximum therapeutic efficacy. The matrix regulates the rate at which the drug is released. Because it facilitates prolonged release, the major excipient in the formulation is a release retardant. The technology may promote patient compliance and efficiently treat chronic illnesses by decreasing the overall dosage and dosing schedule. The drug is supplied in this system via diffusion- and dissolution-controlled methods. The primary g

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Addanki Anusha, Krishnaphanisri Ponnekanti, Ramanuj Tiwari, L. Swapna, Md Mabrur Hussain, and A Siddhardha. "A review of medicines with sustained release." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 221–33. http://dx.doi.org/10.30574/wjbphs.2023.13.3.0141.

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Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties for maximum therapeutic efficacy. The matrix regulates the rate at which the drug is released. Because it facilitates prolonged release, the major excipient in the formulation is a release retardant. The technology may promote patient compliance and efficiently treat chronic illnesses by decreasing the overall dosage and dosing schedule. The drug is supplied in this system via diffusion- and dissolution-controlled methods. The primary goal

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KATO, Yasutomi, Hisakazu SUNADA, Yorinobu YONEZAWA, and Ryuzo ISHINO. "Sustained Release Mechanisms of Wax Matrix System for Controlled Release." CHEMICAL & PHARMACEUTICAL BULLETIN 42, no. 8 (1994): 1646–50. http://dx.doi.org/10.1248/cpb.42.1646.

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Khoder, Mouhamad, Henry Gbormoi, Ali Ryan, Ayman Karam, and Raid Alany. "Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads." Pharmaceutics 11, no. 2 (2019): 83. http://dx.doi.org/10.3390/pharmaceutics11020083.

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In this study, bovine serum albumin (BSA) and alginate (ALG) conjugates were synthesized by the Maillard reaction in order to evaluate their potential to develop controlled release drug delivery systems. The progress of the Maillard reaction was evidenced using ultraviolet (UV) absorbance, determination of BSA remaining free amino groups, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). BSA-ALG conjugates possessed enhanced and tunable viscosity, foamability and foam stability. Foam generated from BSA-ALG conjugate solution was used to prepare floating gastroretentive

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Bodhankar, Shishupal S., and Mohini Sihare. "Formulation and Evaluation of Multiparticulate Pellet Systems for Antidiabetic and Antihypertensive Drugs: Application of Extrusion– Spheronization and Solution Layering Techniques." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–08. https://doi.org/10.25258/ijddt.15.2.10.

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The present study focuses on the development and comprehensive evaluation of sustained and controlled release multiparticulate pellet formulations for three therapeutic agents: Tolbutamide, Saxagliptin, and Verapamil. The primary objective was to enhance drug release profiles and patient compliance using extrusion–spheronization and solution layering techniques. Tolbutamide and Verapamil were formulated into matrix-based sustained release pellets using hydrophilic polymers (HPMC) and plasticizers (MCC), while Saxagliptin pellets were prepared via solution layering on nonpareil seeds with optio

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Bayer, Ilker S. "Controlled Drug Release from Nanoengineered Polysaccharides." Pharmaceutics 15, no. 5 (2023): 1364. http://dx.doi.org/10.3390/pharmaceutics15051364.

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Polysaccharides are naturally occurring complex molecules with exceptional physicochemical properties and bioactivities. They originate from plant, animal, and microbial-based resources and processes and can be chemically modified. The biocompatibility and biodegradability of polysaccharides enable their increased use in nanoscale synthesis and engineering for drug encapsulation and release. This review focuses on sustained drug release studies from nanoscale polysaccharides in the fields of nanotechnology and biomedical sciences. Particular emphasis is placed on drug release kinetics and rele

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Sadhu, Venkateswara Rao, Priyanka Bopparaju, and Padmalatha Kantamneni. "Bilayer tablet technology: A novel approach." GSC Biological and Pharmaceutical Sciences 7, no. 2 (2019): 022–28. https://doi.org/10.5281/zenodo.4286145.

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Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second lay

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CHRYSANT, S., and M. COHEN. "Sustained blood pressure control with controlled-release isradipine." American Journal of Hypertension 8, no. 1 (1995): 87–89. http://dx.doi.org/10.1016/0895-7061(94)00158-8.

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Sahu, Dr Gyanesh Kumar. "A Review on Role of Sustained Release Tablets in Improving Patient Compliance and Therapeutic Outcomes." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 12 (2024): 1–7. https://doi.org/10.55041/ijsrem39580.

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Sustained release tablets represent a significant advancement in pharmaceutical drug delivery, offering controlled and prolonged release of active ingredients to enhance therapeutic outcomes. This novel approach addresses the limitations of conventional dosage forms by maintaining consistent plasma drug levels, reducing dosing frequency, and improving patient compliance. Sustained release systems utilize various technologies, including matrix systems, reservoir systems, and osmotic pumps, to regulate drug release over an extended period. This review provides a comprehensive analysis of the des

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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controll

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Sarthak, Keluskar* Rachel Geevarghese Swapnil Phalak. "Nanoparticles Based Sustained Release Tablets: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4615–24. https://doi.org/10.5281/zenodo.15538501.

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Nanoparticle-based sustained release tablets represent a transformative advancement in the field of pharmaceutical technology, offering numerous benefits over conventional drug delivery systems. These formulations are designed to release therapeutic agents at a controlled rate over an extended period, thereby improving drug bioavailability, reducing dosing frequency, and enhancing patient adherence. By incorporating drugs into nanoparticles, it is possible to modify pharmacokinetic profiles, ensure consistent plasma drug levels, and minimize peak-trough fluctuations, which can lead to adverse

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Gunawardana, Manjula, Madeline Mullen, Jennifer Yoo, Paul Webster, John A. Moss, and Marc M. Baum. "Sustained Delivery of Commensal Bacteria from Pod-Intravaginal Rings." Antimicrobial Agents and Chemotherapy 58, no. 4 (2014): 2262–67. http://dx.doi.org/10.1128/aac.02542-13.

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ABSTRACTTopical administration of live commensal bacteria to the vaginal tract holds significant potential as a cost-effective strategy for the treatment of sexually transmitted infections and the delivery of mucosal vaccines. Probiotic-releasing intravaginal rings (IVRs) embody significant theoretical advantages over traditional daily-dosage forms, such as sustained and controlled delivery leading to improved adherence to therapy compared to that of frequent dosing. The conventional IVR designs, however, are not amenable to the delivery of live bacteria. We have developed a novel pod-IVR tech

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Prof., Madhuri T. Deshmukh Ganesh Deokate *. Prof. R.V. Shete. "A REVIEW ON BILAYER TECHNOLOGY." Journal of Pharma Research 8, no. 3 (2019): 81–87. https://doi.org/10.5281/zenodo.2620324.

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<strong><em>ABSTRACT</em></strong> <strong><em>O</em></strong><em>ver the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled & immediate release drug delivery systems. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for sustained release of tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. S

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Rohan, Waghmare*1 Surekha Khamkar2. "Formulation and Evaluation of Sustained Release Metronidazole Tablet." International Journal of Scientific Research and Technology 2, no. 5 (2025): 355–63. https://doi.org/10.5281/zenodo.15421602.

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Metronidazole, an antibiotic commonly used to treat infections caused by anaerobic bacteria and certain protozoa, has a broad spectrum of activity. However, its frequent dosing regimen due to its short half-life often leads to poor patient compliance and fluctuations in plasma drug concentrations. The development of sustained-release formulations of metronidazole aims to improve its therapeutic effectiveness, enhance patient adherence, and minimize side effects.This study focuses on the formulation and evaluation of sustained-release (SR) tablets of metronidazole. The SR formulation was design

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Nalbadis, Anastasios, Marie-Luise Trutschel, Henrike Lucas, Jana Luetzkendorf, Annette Meister, and Karsten Mäder. "Selection and Incorporation of siRNA Carrying Non-Viral Vector for Sustained Delivery from Gellan Gum Hydrogels." Pharmaceutics 13, no. 10 (2021): 1546. http://dx.doi.org/10.3390/pharmaceutics13101546.

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The local controlled release of siRNA is an attractive and rational strategy to enhance and extend the effectiveness of gene therapy. Since naked and unmodified siRNA has a limited cell uptake and knockdown efficiency, the complexation of siRNA with non-viral carriers is often necessary for the delivery of bioactive RNA. We evaluated the performance of three different non-viral siRNA carriers, including DOTAP lipoplexes (DL), chitosan polyplexes (CP), and solid lipid complexes (SLC). The physicochemical properties of the siRNA-nanocarriers were characterized by dynamic light scattering and gel

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Nakanishi, Ko, Yosuke Bando, Tomohiko Katsurayama, et al. "Controlled Ion Release Property of Glass Ionomer Cement Containing Nanoporous Silica Particles." Key Engineering Materials 720 (November 2016): 17–20. http://dx.doi.org/10.4028/www.scientific.net/kem.720.17.

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Controlled ion release property of nanoporous silica particles (NPS) were investigated using cationic fluorescent dye, rhodamine B. The dye was charged into a glass ionomer cements (GIC) pellet containing the particles and then the pellet were immersed into distilled water. The dye-release behavior was observed using a UV-vis. spectrophotometer. GIC containing NPS can release the dye for a couple of weeks, where as other samples released it only a few days. This result suggests that NPS has excellent sustained dye-release property.

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Deepthi, V. Phani, AMPAPURAM RAJESH PAVAN, G. Naresh Babu, and K. Sreenivasulu. "Formulation and Evaluation of Prulifloxacin Sustained Release Matrix Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 72–81. http://dx.doi.org/10.22270/jddt.v9i4.2974.

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Prulifloxacin is a chemotherapeutic antibiotic of Fluor quinolone drug used to treat a various urinary tract infections. It has short half-life, makes the sustained release (SR) forms extremely advantageous. Sustained release tablets results in increased bioavailability. The purpose of the present study was to develop a sustain release matrix drug delivery system (SR) containing Prulifloxacin as a model drug by using various proportions of polymers such as HPMC E15, HPMC K15. The sustained release formulations of Prulifloxacin were prepared by direct compression method. Optimization of formula

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Harshada, Auti* Adinath Sangale Dr. Megha Salve. "A Brief Review on Sustained Release Matrix Tablets." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 977–90. https://doi.org/10.5281/zenodo.14209075.

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To improve patient compliance, reduce the frequency of dose, and maintain constant drug plasma levels, sustained-release matrix tablets are a cutting-edge drug delivery method that releases therapeutic agents over an extended period. The principles, formulation techniques, and assessment methodologies related to sustained-release matrix tablets are all thoroughly covered in this paper. The notion of sustained release systems is introduced at the outset, with an emphasis on its benefits over traditional dose forms, especially in the treatment of chronic illnesses. The presentation includes a th

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Vaishali, S. Kadam G. R. Shendarkar. "ROLE OF NATURAL POLYMER IN SUSTAINED AND CONTROLLED RELEASE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7390–400. https://doi.org/10.5281/zenodo.1006885.

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Now a day there has been an important development in different dosage forms for existing and newly designed drugs and natural products, and synthetic as well as semi-synthetic excipients always need to be used for a variety of purposes. Gums and mucilages are widely used as natural materials for conventional and novel dosage forms. With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in their formulations. Moreover, the tremendous orientation of Pharmaceutical world towards these naturally derived polymers has become a subject

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Tambare, Rashmi Shivaji, Ganesh G. Tapadiya, and Sadhana R. Shahi. "Formulation and Evaluation of Controlled Release Matrix Tablets of Cefixime Trihydrate." Middle East Research Journal of Pharmaceutical Sciences 1, no. 1 (2021): 38–44. http://dx.doi.org/10.36348/merjps.2021.v01i01.005.

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Abstract: The main objective of the present work was to develop sustained release matrix tablets of Cefixime Trihydrate were prepared by direct compression techniques and evaluates the effect of formulation variables such as lubricant, binder, polymer content and viscosity grades of HPMC on the behavior of Cefixime Trihydrate release. The prepared tablets were evaluated for various physico-chemical parameters. In vitro release profile was check to evaluate the sustained release matrix tablet of Cefixime Trihydrate. The drug release from the optimized formulation was found to follow zero order

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Chen, Zhongjian, Quangang Zhu, Jianping Qi, Yi Lu, and Wei Wu. "Sustained and controlled release of herbal medicines: The concept of synchronized release." International Journal of Pharmaceutics 560 (April 2019): 116–25. http://dx.doi.org/10.1016/j.ijpharm.2019.01.074.

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Gangurde, Gayatri* Dhum Manohar Gavali Prashant Sonawane Mitesh. "Review on Bilayer Tablets." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1192–203. https://doi.org/10.5281/zenodo.15019244.

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Bi-layer tablets are essential for developing both immediate and modified drug delivery systems for various diseases. They facilitate controlled medication release, representing a significant advancement in Controlled Drug Delivery Systems (CDDS) and improving the effectiveness of medication delivery. Over the past 30 years, the complexity and costs of introducing new drugs have increased, leading to greater focus on sustained or controlled release systems. Bi-layer tablets enable precise delivery of medications with predetermined release profiles, preventing chemical incompatibilities between

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NIZAMI, FARIDA, and YOGENDRA MALVIYA. "RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW." Current Research in Pharmaceutical Sciences 11, no. 4 (2022): 91–97. http://dx.doi.org/10.24092/crps.2021.110401.

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Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermin

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Anjali, Bagmar, and Tikariya Komal. "SUSTAINED RELEASE MATRIX DRUG DELIVERY SYSTEM: AN OVERVIEW." International Journal of Pharmaceutical Sciences and Medicine 6, no. 9 (2021): 79–87. http://dx.doi.org/10.47760/ijpsm.2021.v06i09.006.

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Oral delivery of drugs is the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation, etc. Sustained release constitutes are the dosage form that provides medication over an extended time or denotes that the system is able to provide some actual therapeutic control whether this is of a temporal nature, spatial nature or both. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance del

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Stebbins, N. D., J. J. Faig, W. Yu, R. Guliyev, and K. E. Uhrich. "Polyactives: controlled and sustained bioactive release via hydrolytic degradation." Biomaterials Science 3, no. 8 (2015): 1171–87. http://dx.doi.org/10.1039/c5bm00051c.

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Teller, Ryan S., Rachna Rastogi, Todd J. Johnson, Michael J. Blair, Robert W. Hitchcock, and Patrick F. Kiser. "Intravaginal Flux Controlled Pump for Sustained Release of Macromolecules." Pharmaceutical Research 31, no. 9 (2014): 2344–53. http://dx.doi.org/10.1007/s11095-014-1331-5.

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Ghansham, Pharande* Someshwar More Dr. V. M. satpute S. R. Ghodake. "Formulation and Evaluation of Sustained Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1070–72. https://doi.org/10.5281/zenodo.14643179.

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Sustained release tablets represent a vital advancement in pharmaceutical technology, providing a controlled and prolonged release of active pharmaceutical ingredients (APIs). This approach ensures steady therapeutic drug levels, reduced dosing frequency, and improved patient compliance, particularly for chronic conditions requiring long-term treatment. Formulating these tablets involves the strategic use of polymers, hydrophilic and hydrophobic matrix systems, and advanced manufacturing techniques such as direct compression and hot-melt extrusion. Evaluation focuses on critical quality attrib

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Mamidala, Ranjith Kumar, Vamshi Ramana, Sandeep G, Meka Lingam, Ramesh Gannu, and Madhusudan Rao Yamsani. "Factors Influencing the Design and Performance of Oral Sustained/Controlled Release Dosage Forms." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 583–94. http://dx.doi.org/10.37285/ijpsn.2009.2.3.1.

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Of all drug delivery systems, oral drug delivery remains the most preferred option for administration for various drugs. Availability of wide variety of polymers and frequent dosing intervals helps the formulation scientist to develop sustained/controlled release products. Oral Sustained release (S.R) / Controlled release (C.R) products provide an advantage over conventional dosage forms by optimizing bio-pharmaceutic, pharmacokinetic and pharmacodynamic properties of drugs in such a way that it reduces dosing frequency to an extent that once daily dose is sufficient for therapeutic management

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Rathore, Kavita, C. K. Tyagi, Harish Pandey, and Sunil Kumar Shah. "PREPARE AND EVALUATE MUCOADHESIVE FORMULATIONS OF LAMIVUDINE WITH BETTER CONTROLLED/ SUSTAINED DRUG RELEASE PROFILE." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 694–700. http://dx.doi.org/10.22270/jddt.v9i4-a.3479.

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The aim of present study was to formulate & evaluate the mucoadhesive sustained release formulations of lamivudine and to fulfill this aim, two mucoadhesive formulations Gels and Tablets were prepared by using three different polymers: HPMC K15, poloxamer 407 & carbopol 934. Three mucoadhesive gel and nine tablet formulations were prepared and evaluated for various parameters. All three gels were able to give sustained release up to 12 hours. Tablet formulations, F1 to F5 failed to fulfill the aim. Only F6, F7, F8 & F9 formulations were selected, as all gave sustained release up to

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Park, Kyung Hee, Yeon Woo Choi, Heejoo Ryu, et al. "Controlled Drug Release Using Chitosan-Alginate-Gentamicin Multi-Component Beads." Materials 15, no. 21 (2022): 7682. http://dx.doi.org/10.3390/ma15217682.

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This study aimed to develop improved multi-component beads with controlled, sustained delivery of antibiotics, such as gentamicin (GM). Antibiotic-loaded beads with rapid-release and the sustained-release system can be used for bone restoration. Single and multi-component beads were prepared by gelation using various combinations of chitosan and calcium chloride as cationic components and alginate and citric acid as anions. GM release was also controlled by crosslinking using citric acid. The optimum beads were obtained using 5% or 2% sodium alginate, 3% chitosan, and 0.1 mol/L citric acid. Th

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G. Ingle, Tushar Kumar, Shrikant D. Pande, Sandeep Atram, Nishant Bobade, and Vikrant Wankhede. "Formulation and Evaluation of Microspheres for Colon Targeted Drug Delivery Using Anthelminthics Drugs." Asian Journal of Pharmaceutical Research and Development 11, no. 4 (2023): 36–45. http://dx.doi.org/10.22270/ajprd.v11i4.1283.

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The objective of this study was to develop sustained release microspheres for colon-targeted drug delivery system to enhance therapeutic efficacy while minimizing systemic side effects. The controlled and prolonged release of drugs in the colon can significantly improve the treatment outcomes for various colon-related diseases. Microspheres, small spherical particles with sizes ranging from 1 to 1000 micrometers, were formulated using biodegradable polymers and natural materials to ensure biocompatibility and controlled drug release. The formulation process involved the selection of appropriat

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S., Iswarya*, V. Kalvimoorthi Dr., Gopi L., Haripriya A., and K. Kaveri Dr. "DEVELOPMENT OF SUSTAINED RELEASE CARVEDILOL TABLETS USING POLYMER-BASED MATRIX SYSTEMS." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 784–90. https://doi.org/10.5281/zenodo.15274490.

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This study focuses on the development of sustained-release (SR) tablets of Carvedilol using a matrix system with swellable polymers. The formulation included Hydroxypropyl Methylcellulose (HPMC), Microcrystalline Cellulose (MCC), and Ethylcellulose (EC) to achieve a controlled release over 12 hours. Various SR formulations were prepared using the wet granulation technique and evaluated for physical, chemical, and stability characteristics. Results showed that the physical characteristics of the formulations were satisfactory, and tablets met the official monograph criteria for assay, weight va

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Chetan, Patil* Rohini Patil Ajit Patil. "A Comprehensive Review of Matrix Tablets and Assessment Techniques." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1047–57. https://doi.org/10.5281/zenodo.15014891.

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Matrix with sustained release tablets have changed the way of drug delivery by exhibiting controlled release of drugs, increasing therapeutic effect, and improving compliance of the patient. The systems decrease frequency of dosing, reduce side effects, and provide stable drug levels in the body, which are a mainstay of contemporary pharmaceutical science. This review provides an overview of the matrix tablets with regard to their classification into hydrophobic, hydrophilic, lipid, and biodegradable matrices, as well as mechanisms of drug release, viz diffusion, dissolution, and erosion. Vari

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Yadav, Rajkumar Prasad, F. R. Sheeba, Mukesh Sharma, Bhargav A, Yaswanth Kumar, and Akshay Kumar Patel. "The Role of Matrix Tablet in Oral Drug Delivery System." Asian Journal of Pharmaceutical Research and Development 9, no. 2 (2021): 80–86. http://dx.doi.org/10.22270/ajprd.v9i2.930.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The important route of drug administered by oral route. The oral dosage forms developed and improvedthe patient compliance. The oral controlled release system has been developed by change to formulation scientist, due to the inability to restrain and localized of a system at target area of the gastrointestinal tract. The hydrophilic polymers are becomes product of choice for important ingredients formulation of sustained release dosage forms.The benefit of sustained release dosage forms are compared to the co

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Rajput, Rajesh, K. M. K. Prasanna Kumar, D. S. Arya, et al. "Osmotic controlled drug delivery system (OSMO technology) and its impact on diabetes care." International Journal of Research in Medical Sciences 9, no. 1 (2020): 303. http://dx.doi.org/10.18203/2320-6012.ijrms20205861.

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Recently, focus on the development of controlled release drug delivery system has increased, as existing drugs exhibit certain pharmacokinetic limitations. The major goal of designing sustained release formulations is to improve the drug performance by prolonged duration of drug action, decreased frequency of dosing and reduced side effects by using smallest quantity of drug administered by the most suitable route. Osmotic-controlled release oral delivery system (OSMO technology) is the most promising strategy based system for sustained delivery of drug. Drug can be delivered in a controlled m

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Singh, Jyoti Bhusan, Pramod Mourya, Gopal Rai, and Rajesh Shukla. "FORMULATION AND IN-VITRO EVALUATION OF NICARDIPINE HYDROCHLORIDE BILAYERED TABLET FOR CONTROLLED RELEASE." Journal of Advanced Scientific Research 13, no. 11 (2022): 58–62. http://dx.doi.org/10.55218/jasr.2022131109.

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The aim of present research work was to prepare and evaluate the controlled release bilayered tablet of Nicardipine HCL to improve its bioavailability for the treatment of hypertension. To minimize critical process parameters, two layer compression method was used for the formulation of Bilayered tablets. The appropriate formulation was achieved successfully with the combination of Polymers MCC, Carbopol 71G and HPMC K100M produced desired release profile for Metoprolol succinate extended release layer. The combination of disintegrating agents that is Sodium starch glycolate and Dicalcium phos

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Nnanyereugo, Chinelo Emmanuella, and Ogbonna Okorie. "Application of Acetylated Corn Starch as a Sustained Release Formulation in Metronidazole Tablets." Journal of Drug Delivery and Therapeutics 15, no. 5 (2025): 78–85. https://doi.org/10.22270/jddt.v15i5.7141.

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Objective(s): This study aimed to assess the impact of acetylation on the disintegrant properties of corn starch and evaluate its effectiveness as a sustained release formulation in metronidazole tablets. Design: Experimental study involving acetylation of corn starch using acetic anhydride. Intervention(s): Formulation of granules with varying concentrations of acetylated corn starch as disintegrant, followed by tablet production. Main Outcome Measure(s): Disintegration time, sustained release of metronidazole, tablet properties (friability, hardness, content uniformity), and release kinetics

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Ryu, Suji, Seungyeop Park, Ha Yeon Lee, Hyungjun Lee, Cheong-Weon Cho, and Jong-Suep Baek. "Biodegradable Nanoparticles-Loaded PLGA Microcapsule for the Enhanced Encapsulation Efficiency and Controlled Release of Hydrophilic Drug." International Journal of Molecular Sciences 22, no. 6 (2021): 2792. http://dx.doi.org/10.3390/ijms22062792.

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Recently, nano- and micro-particulate systems have been widely utilized to deliver pharmaceutical compounds to achieve enhanced therapeutic effects and reduced side effects. Poly (DL-lactide-co-glycolide) (PLGA), as one of the biodegradable polyesters, has been widely used to fabricate particulate systems because of advantages including controlled and sustained release, biodegradability, and biocompatibility. However, PLGA is known for low encapsulation efficiency (%) and insufficient controlled release of water-soluble drugs. It would result in fluctuation in the plasma levels and unexpected

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Ms. Prachi Rohal, Ms Prachi Rohal, and Mrs Ritu Chauhan Mrs.Ritu Chauhan. "Formulation and Evaluation of Metronidazole Loaded Cross Linked Sodium Alginate and Xanthum Gum Microspheres." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 351–53. https://doi.org/10.35629/4494-1003351353.

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Metronidazole-loaded microspheres, formulated with sodium alginate and xanthan gum via ionotropic gelation, were developed and evaluated for controlled drug delivery. Varying polymer ratios and crosslinking agent concentrations yielded microspheres characterized for size, entrapment efficiency, swelling, morphology, and in vitro release. FTIR and DSC confirmed drug-polymer compatibility. Spherical morphology with smooth surfaces was observed via SEM. Polymer blend ratios significantly influenced drug release, achieving sustained release over 12 hours. Formulation F4 (1:1 polymer ratio, optimiz

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Samrudh, Shinde Shivaji Patil Namrata Satkar Pritam Salokhe Nilesh Chougule. "Formulation And Evaluation Of Floating Sustain Release Tablet Of Ranolazine." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1505–16. https://doi.org/10.5281/zenodo.12788828.

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This research focuses on the formulation and evaluation of floating sustained-release tablets of Ranolazine, an anti-anginal agent with poor bioavailability and short half-life. The tablets were prepared using various polymers such as hydroxypropyl methylcellulose (HPMC) and sodium alginate to achieve controlled drug release and prolonged gastric residence time. The formulation was optimized using a 32 full factorial design to study the effect of independent variables like polymer concentration and tablet hardness on drug release kinetics and floating behavior. The prepared tablets exhibited e

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Wen, Li-Xiong, Hao-Min Ding, Jie-Xin Wang, and Jian-Feng Chen. "Porous Hollow Silica Nanoparticles as Carriers for Controlled Delivery of Ibuprofen to Small Intestine." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 3139–44. http://dx.doi.org/10.1166/jnn.2006.410.

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With two different methods, ibuprofen was entrapped into porous hollow silica nanoparticles (PHSNs) carriers, which were synthesized through a sol–gel route by using CaCO3 nanoparticles as the inorganic templates. By employing pressured CO2 as the loading medium, the amount of ibuprofen that was pressed into the carriers was ∼52% higher than that by simply soaking. The drug release behaviors of the ibuprofen-loaded PHSNs were investigated in a simulated intestine juice and an artificial gastric fluid, respectively, and it demonstrated a sustained release pattern in all cases and the sample pre

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Singh, Priyanka, Amit Kumar Shrivastava, Sachin Kumar, and Manish Dhar Dwivedi. "Formulation and Evaluation of Sustained Release Matrix Tablets of Aceclofenac." Borneo Journal of Pharmacy 4, no. 2 (2021): 99–109. http://dx.doi.org/10.33084/bjop.v4i2.1854.

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This study aimed to improve the dissolution rate of aceclofenac and release the drug in a controlled manner over a period of 24 hours. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/guar gum). Matrix tablets were prepared by wet granulation method using different hydrophilic polymers (HPMC/guar gum). Tablets were evaluated for in vitro drug release profile in phosphate buffer with pH 6.8 (without enzymes). The thickness and hardness of prepared tablets were 3.23 ± 0.035 to 3.28 ± 0.008 mm and 3.26 ± 0.115 to 3.60 ± 0.200 kg/cm2, respectively. The fr

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Abhay, Dhakare* Dr. A. V. Chandewar Dr. Shilpa Gawande Anisha Kohale. "Development And Evaluation of Sustained Release Formulation by Spray Drying Technique." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1506–21. https://doi.org/10.5281/zenodo.15380205.

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The present study focuses on the development and evaluation of sustained release microspheres of Vinpocetine, a poorly water-soluble drug with a short biological half-life, using the spray drying technique. The objective was to enhance the drug’s bioavailability and prolong its therapeutic effect through controlled release delivery. Ethyl cellulose and hydroxypropyl methylcellulose (HPMC) were employed as polymeric carriers to encapsulate Vinpocetine, with varying polymer-to-drug ratios. The prepared microspheres were characterized for particle size, morphology, drug entrapment efficienc

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Sahu, Ayush, Khushi Chouksey, and Kuldeep Ganju. "FORMULATION AND EVALUATION OF CIPROFLOXACIN HYDROCHLORIDE SUSTAINED RELEASE TABLETS USING HIBISCUS ROSA SINENSIS MUCILAGE." Journal of Advanced Scientific Research 13, no. 08 (2022): 71–78. http://dx.doi.org/10.55218/jasr.202213811.

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Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Delivery systems extended release or controlled release rate can achieve predictable and reproducible, the extended duration of activity for the short time of life - drugs, reduced toxicity, and dose reduction request, the optimized therapy and better patient compliance. It is controlled primarily by the type and the proportion of the polymers used in the preparation. Ciprofloxacin hydrochloride is an extreme

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Singh, Rashi, and Ashwini Bharati. "Review: Controlled Release of Analgesics." International Journal for Research in Applied Science and Engineering Technology 11, no. 2 (2023): 654–59. http://dx.doi.org/10.22214/ijraset.2023.49109.

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Abstract: The regulated release of medication into the patient provided by the patch makes transdermal drug delivery superior to other methods of pharmaceutical administration. The medication instantly enters the bloodstream through the skin. Low concentration in the blood and high concentration on the patch. The usage of polymers is successful in achieving analgesics' sustained release. To evaluate effectiveness, in vitro and in vivo investigations were conducted. Due to the advantages that biodegradable polymers have over other materials in use, there is currently a huge demand for them. A b

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Wakui, Yoshito, and Takafumi Aizawa. "Analysis of Sustained Release Behavior of Drug-Containing Tablet Prepared by CO2-Assisted Polymer Compression." Polymers 10, no. 12 (2018): 1405. http://dx.doi.org/10.3390/polym10121405.

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A controlled-release system for drug delivery allows the continuous supply of a drug to the target region at a predetermined rate for a specified period of time. Herein, the sustained release behavior of a drug-containing tablet fabricated through CO2-assisted polymer compression (CAPC) was investigated. CAPC involves placing the drug in the center of a nonwoven fabric, sandwiching this fabric between an integer number of nonwoven fabrics, and applying pressure bonding. An elution test, in which the drug-carrying tablet was immersed in water, showed that sustained-release performance can be co

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Kumar, Putta Rajesh, Meena N, Poojitha P, Sowjanya P, Shivaleela U, and Sharma JVC. "Formulation Design and in Vitro Evaluation Studies of Antidepressant Venlafaxine Hydrochloride Oral Drug Delivery Systems." Journal of Biomedical and Pharmaceutical Research 13, no. 2 (2024): 51–63. http://dx.doi.org/10.32553/jbpr.v13i2.1084.

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Background: Venlafaxine Hydrochloride a serotonin, nor epinephrine reuptake inhibitor, oral antidepressant used to treat depression. Objective: The present study was aimed at studying controlled release of Venlafaxine Hydrochloride with Guargum, Hydroxy propyl methyl cellulose as matrix polymers, Micro crystalline cellulose as binder and Dicalcium phosphate as diluent filler. Methods: Tablets were studied for pre, post compression, swelling and in vitro dissolution studies. Drug release was analyzed by release kinetic models. Results: Preformulation studies revealed that the drug procured was

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