Teses / dissertações sobre o tema "Cyclical bend"

Disertacijoje, taikant apkrovų pasiskirstymo sriegio vijose modeliavimą, nagrinėjamos lenkiamų srieginių jungčių mažaciklio stiprumo problemos. Mo-dernesnės daugiaciklio ir mažaciklio ilgaamžiškumo skaičiavimo metodikos detaliai kiekybiškai įvertina ašinės apkrovos pasiskirstymą vijose, kuris leidžia detaliau ir tiksliau įvertinti konstrukcijos ypatumų įtaką. Disertacijoje siekiama ir cikliškai lenkiamoms srieginėms jungtims sukurti apkrovos pasiskirstymo sriegyje skaičiavimo metodą ir pritaikyti jį ciklinio stiprumo skaičiavimui Sudaryta lenkiamos srieginės jungties elementų poslinkių darnos lygtis įga-lino sukurti trijų ruožų ir daugiaruožį lenkimo apkrovos pasiskirstymo jung¬tyje modelius ir įdiegti juos į norminio mažaciklio ilgaamžiškumo skaičiavimo gran-dinę. Pirmame skyriuje pateikta literatūros šaltinių analizė. Jame apžvelgiama sunkiai apkrautų srieginių jungčių taikymo sritis ir apkrovimo sąlygos, apžvel¬giami ir analizuojami atlikti tyrimai, susiję su srieginių jungčių cikliniu stipru-mu. Antrame skyriuje pateikti sriegio vijų poros deformavimo savybių eksperi¬mentinio tyrimo rezultatai ir anksčiau literatūroje neminėtų nukraunamos ir pa-kartotinai apkraunamos vijų poros savybių analizė. Trečiame skyriuje pateikta srieginės jungties elementų deformavimo sche¬ma, poslinkių darnos diferencialinės lygtys, diferencialinių lygčių analitiniai sprendiniai ir lenkiamos srieginės jungties modeliai – trijų ruožų ir daugiaruožis tamprieji modeliai lenkimo apkrovos... [toliau žr. visą tekstą]
Industry equipment such as pressure vessels, mining equipment, heat exchang-ers, steam generators and other structures are provided with bolted closures for the purpose of in-service inspection and maintenance of internal components. Threaded connections often experience variable cyclic loads due to temperature, inner pressure and variation in the deformation of connection fittings. Often, studs and screws are not only affected by an axial load, but also by bending moments. More sophisticated high-cycle and low-cycle durability calculation meth-odologies have been already developed for threaded connections experiencing cyclic axial loads, and in these methodologies the distribution of axial load among turns is assessed quantitatively. The quantitative data of load distribu-tion in the thread enables a more accurate assessment of the influence of the constructional design particularities (connection length, material, nut and turn’s form) and the deformation stages of the connection element. These durability calculation methodologies are not applied for threaded connections that are cyclically bent, as the analytical models that are suitable for practical application in the load distribution of the turns have not been cre-ated for bent threaded connections. In this field, no models have been created to be calculated by the BE method. As the threaded connection is a complex node consisting of deformed el-ements, the load distribution among turns is influenced by the... [to full text]

Industry equipment such as pressure vessels, mining equipment, heat exchang-ers, steam generators and other structures are provided with bolted closures for the purpose of in-service inspection and maintenance of internal components. Threaded connections often experience variable cyclic loads due to temperature, inner pressure and variation in the deformation of connection fittings. Often, studs and screws are not only affected by an axial load, but also by bending moments. More sophisticated high-cycle and low-cycle durability calculation meth-odologies have been already developed for threaded connections experiencing cyclic axial loads, and in these methodologies the distribution of axial load among turns is assessed quantitatively. The quantitative data of load distribu-tion in the thread enables a more accurate assessment of the influence of the constructional design particularities (connection length, material, nut and turn’s form) and the deformation stages of the connection element. These durability calculation methodologies are not applied for threaded connections that are cyclically bent, as the analytical models that are suitable for practical application in the load distribution of the turns have not been cre-ated for bent threaded connections. In this field, no models have been created to be calculated by the BE method. As the threaded connection is a complex node consisting of deformed el-ements, the load distribution among turns is influenced by the... [to full text]
Srieginės jungtys dažnai patiria ciklinių lenkimo apkrovų dėl temperatū-ros, vidaus slėgio ir jungiamųjų detalių deformacijų kitimo. Srieginėms jung-tims, kurios patiria ašinių ciklinių apkrovų jau yra sukurtos modernesnės daugiaciklio ir mažaciklio ilgaamžiškumo skaičiavimo metodikos, kuriomis detaliai kiekybiškai įvertinamas ašinės apkrovos pasiskirstymas tarp vijų. Ap-krovos pasiskirstymo sriegyje kiekybiniai duomenys leidžia detaliau ir tiksliau įvertinti konstrukcijos ypatumų (jungties ilgio, medžiagos, veržlės ir vijų for-mos) ir jungties elementų deformavimo stadijų įtaką. Tokios ilgaamžiškumo skaičiavimo metodikos cikliškai lenkiamoms srieginėms jungtims netaikomos, nes lenkiamoms srieginėms jungtims nėra sukurtų apkrovos pasiskirstymo vijose analitinių modelių, tinkamų praktiniam naudojimui. Šioje srityje taip pat nėra sukurtų ir modelių, kurie skaičiuojami baigtinių elementų metodu. Kadangi srieginė jungtis yra kompleksinis mazgas, kurį sudaro deformuo-jami elementai, tai apkrovos pasiskirstymą tarp vijų lemia jungties elementų deformacijų ir poslinkių suderinamumas. Matematiškai aprašant jungties de-formuotą būvį, reikalingi teoriniai ir eksperimentiniai duomenys, kurie atspin-dėtų jungties elementų deformavimo specifinius ypatumus, pasireiškiančius veikiant lenkimui. Disertacijoje siekiama sukurti cikliškai lenkiamų srieginių jungčių apkro-vos pasiskirstymo sriegyje skaičiavimo metodą ir pritaikyti jį mažacikliam ilga-amžiškumui skaičiuoti.

In recent years a significant research focus has been on the development of biomimicking three-dimensional substrates for cell culturing. Hydrogels mimicking the extracellular matrix is a well-suited scaffold for this purpose and there are many different ways these can be cross-linked to retain their shape. The group of Molecular Materials at IFM, Linköping University, is focusing on the development of physical hydrogels hybridized through peptide-peptide interactions but all peptides used for this today are created using rational design and on top of this very large, making them time-consuming and expensive to fabricate. The aim of this project was to evaluate if One Bead One Compound (OBOC) libraries could be used as an alternative to rational design in the finding of cyclic peptide binding partners used in the hybridization of hydrogels. The results were not very promising though since only seven peptides passed all screening steps and of these only two could be sequenced. Of these two, only one was water soluble enough to enable binding interactions analysis but was then found to be a false hit. Nevertheless, it should be noticed that only a fraction of all possible combinations was screened and the results cannot exclude OBOC libraries as an approach in the quest of finding new cyclic peptide binding partners.

Thesis (M.S.)--State University of New York at Binghamton, Thomas J. Watson School of Engineering and Applied Science, Department of Mechanical Engineering, 2007.
Includes bibliographical references.

The increased use of thermoplastics in load carrying components, especially in the automotive industry, drives the needs for a better understanding of its complex mechanical properties. In this thesis work for a master degree in solid mechanics, the mechanical properties of a PA 6/66 resin with and without reinforcement of glass fibers experimentally been investigated. Topics of interest have been the dependency of fiber orientation, residual strains at unloading and compression relative tension properties. The experimental investigation was followed by simulations implementing existing and available constitutive models in the commercial finite element code LS-DYNA. The experimental findings showed that the orientation of the fibers significantly affects the mechanical properties. The ultimate tensile strength differed approximately 50% between along and cross flow direction and the cross-flow properties are closer to the ones of the unfilled resin, i.e. the matrix material. An elastic-plastic model with Hill’s yield criterion was used to capture the anisotropy in a simulation of the tensile test. Residual strains were measured during strain recovery from different load levels and the experimental findings were implemented in an elastic-plastic damage model to predict the permanent strains after unloading. Compression tests showed that a stiffer response is obtained for strains above 3% in comparison to tension. The increased stiffness in compression is although too small to significantly influence a simulation of a 3 point bend test using a material model dependent of the hydrostatic stress.

La plupart des processus cellulaires et biologiques reposent, à un certain niveau, sur des interactions protéine-protéine (IPP). Leur manipulation avec des composés chimiques démontre un grand potentiel pour la découverte de nouveaux médicaments. Malgré la demande toujours croissante en molécules capables d'interrompre sélectivement des IPP, le développement d'inhibiteurs d’IPP est fortement limité par la grande taille de la surface d'interaction. En considérant la nature de cette surface, la capacité à mimer des structures secondaires de protéines est très importante pour lier une protéine et inhiber une IPP. Avec leurs grandes capacités peptidomimétiques et leurs propriétés pharmacologiques intéressan-tes, les peptides cycliques sont des prototypes moléculaires de choix pour découvrir des ligands de protéines et développer de nouveaux inhibiteurs d’IPP. Afin d’exploiter pleinement la grande diversité accessible avec les peptides cycliques, l’approche combinatoire «one-bead-one-compound» (OBOC) est l’approche la plus accessible et puissante. Cependant, l'utilisation des peptides cycliques dans les chimiothèques OBOC est limitée par les difficultés à séquencer les composés actifs après le criblage. Sans amine libre en N-terminal, la dégradation d'Edman et la spectrométrie de masse en tandem (MS/MS) ne peuvent pas être utilisées. À cet égard, nous avons développé de nouvelles approches par ouverture de cycle pour préparer et décoder des chimiothèques OBOC de peptides cycliques. Notre stratégie était d'introduire un résidu sensible dans le macrocycle et comme ancrage pour permettre la linéarisation des peptides et leur largage des billes pour le séquençage par MS/MS. Tout d'abord, des résidus sensibles aux nucléophiles, aux ultraviolets ou au bromure de cyanogène ont été introduits dans un peptide cyclique et leurs rendements de clivage évalués. Ensuite, les résidus les plus prometteurs ont été utilisés dans la conception et le développement d’approches en tandem ouverture de cycle / clivage pour le décodage de chimiothèques OBOC de peptides cycliques. Dans la première approche, une méthionine a été introduite dans le macrocycle comme ancrage pour simultanément permettre l’ouverture du cycle et le clivage des billes par traitement au bromure de cyanogène. Dans la seconde approche, un résidu photosensible a été utilisé dans le macrocycle comme ancrage pour permettre l’ouverture du cycle et le clivage suite à une irradiation aux ultraviolets. Le peptide linéaire généré par ces approches peut alors être efficacement séquencé par MS/MS. Enfin, une chimiothèque OBOC a été préparée et criblée la protéine HIV-1 Nef pour identifier des ligands sélectifs. Le développement de ces méthodologies permttra l'utilisation de composés macrocycliques dans les chimiothèques OBOC et constitue une contribution importante en chimie médicinale pour la découverte de ligands de protéines et le développement d'inhibiteurs d’IPP.
A great number of cellular and biological processes depend, at some level, on protein-protein interactions (PPI). Their manipulation with chemical compounds has provided a great potential for the discovery of new drugs. Despite the increasing demand for molecules able to interrupt specific PPI, the development of small PPI inhibitors is beset by a number of challenges such as the large size of the interaction interface. Based on the interface’s nature, the ability to mimic protein secondary structures is very important to bind a protein and inhibit PPI. With their interesting peptidomimetic abilities and pharmacological properties, cyclic peptides are very promising templates to discover protein ligands and development new PPI inhibitors. To fully exploit the great diversity accessible with cyclic peptides, the one-bead-one-compound (OBOC) combinatorial method is certainly the most accessible and powerful approach. Unfortunately, the use of cyclic peptides in OBOC libraries is limited by difficulties in sequencing hit compounds after the screening. Lacking a free N-terminal amine, Edman degradation cannot be used on cyclic peptides and complicated fragmentation patterns are obtained by tandem mass spectrometry (MS/MS). In this regard we have designed and developed new convenient ring-opening approaches to prepare and decode OBOC cyclic peptide libraries. Our strategy was to introduce a cleavable residue in the macrocycle and as a linker to allow linearization of peptides and their release from the beads for sequencing by MS/MS. First, amino acid residues sensible to nucleophiles, ultraviolet irradiation or cyanogens bromide were introduced in a model cyclic peptide. Afterward, the most promising residues were used to design and develop tandem ring-opening/cleavage approaches to decode OBOC cyclic peptide libraries. In the first approach a methionine residue was introduced in the macrocycle and as a linker to allow a simultaneous ring-opening and cleavage from the beads upon treatment with cyanogens bromide. In the second approach, a photosensitive residue was used in the macrocycle and as a linker for a dual ring-opening/cleavage upon UV irradiation. The linear peptide generated by these approaches can be efficiently sequenced by tandem mass spectrometry. Finally, an OBOC library has been prepared and screened against the HIV-1 Nef protein to identify selective ligands. The development of these methodologies will prompt the use of macrocyclic compounds in OBOC libraries and be an important contribution in medicinal chemistry for the discovery of protein ligands and the development of PPI inhibitors.

This dissertation presents an analysis of two aspects of the chromatographic separation process known as Simulated Moving Bed (SMB) chromatography. The first aspect is system design, and the second is improving computer simulations to generate heuristics for choosing operational modes. For the past 15-20 years, there has been a surge of interest in the use of Simulated Moving Bed systems for the chromatographic separation of chemicals¹. A wide variety of methods, nomenclatures, and conventions have been adopted over the years²⁻⁴, as teams from different backgrounds adopt and improve on the SMB technology. This work presents a unifying discussion of the two major design methods, Triangle Theory and Standing Wave Design, used in the SMB field. We provide the complete computer code required to execute both design methods. A sample problem is worked, which demonstrates the novelty and ease of use that such tools provide. Mathematica was chosen for the implementation of these design methods, because of its strong symbolic analysis capabilities, and simplicity of creating interfaces for new users. We present derivations of the classic Langmuir results in Mathematica, and proceed to extend those implementations. When analytic solutions are impossible, we use Mathematica's numerical methods. This work also develops a distributed computing tool known as ChromRunner which allows large numbers of detailed numerical simulations to be run simultaneously. The motivations and benefits of this approach are discussed alongside implementation details. We apply the distributed computing system to two separate SMB separations in order to optimize them, as well as determine heuristics governing their operational modes. We wrote ChromRunner in C#, and took advantage of Visual Studio's Entity Framework to create the database backend. The user interface for this software was created using Microsoft's "Windows Presentation Foundation" (WPF) technologies.
Ph. D.

Simulated moving bed chromatography process (SMBCP) is the technical realisation of a countercurrent adsorption process through the cyclic port switching. SMB technology reduces the cost of packing material with high loading capacity and provides high purity and high recovery in a very short time. Major commodity applications have been found in the petroleum, food, biotechnology, pharmaceutical and fine chemical industries. The industrial applications bring an emergent demand to improve the SMBCP operation for higher product quality, productivity, efficiency and robustness. However, for this particular process, we encounter several challenges. Firstly, the interplay of the effects of strong nonlinearities, competition of solutes, mass transfer resistance and fluid dynamic dispersion produces steep concentration fronts. Mathematical model accounted for this particular property constitutes a serious difficulty for the solution procedure. Secondly, a dynamic SMB model consists of a set of partial differential, ordinary differential and algebraic equations, which are highly coupled. The large size is a problem due to its intensive computation when on-line optimisation and real-time control are necessary. Thirdly, the SMB unit operation exhibits complex dynamics. Process metrics for design and operation can be determined only when a cyclic steady state is reached after a certain number of switching. Achieving this steady state by solving the PDE models cycle after cycle involves expensive calculation. Studies have been carried out to solve these problems through process analysis, investigation on spatial discretisation techniques, and development of an accelerated integration scheme.
Through a systematic study on the advances of SMB modelling, design and control, a set of functionally equivalent models for SMBCP are identified and summarized for their practical applications. The limitations of the existing modelling techniques in industrial applications are also identified. Furthermore, structural analysis of the existing models is conducted for a better understanding of the functionality and suitability of each model. Suggestions are given on how to choose an appropriate model with sufficient accuracy while keeping the computational demand reasonably low for real time control.
Effort is made on to the systematic investigation of different numerical methods for the solution of PDEs to circumvent the steep gradients encountered in chromatographic separation. Comprehensive studies are conducted on a single column chromatographic process represented by a transport-dispersive-equilibrium linear model. Numerical solutions from the upwind-1 finite difference, wavelet-collocation, and high resolution methods are evaluated by quantitative comparisons with the analytical solution for a range of Peclet numbers. It reveals that for a PDE system with a low Peclet number, all existing numerical methods work well, but the upwind finite difference method consumes the most time for the same degree of accuracy of the numerical solution. The high resolution method provides an accurate numerical solution for a PDE system with a medium Peclet number. The wavelet collocation method is capable of catching up steep changes in the solution, and thus can be used for solving PDE models with high singularity.
The advantages and disadvantages of the wavelet based approaches are further investigated through several case studies on real SMBCP system. A glucose-fructose separation process is firstly chosen with its relatively simple isotherm representations. Simulations are conducted using both wavelet collocation and upwind finite difference methods. For more complicated applications, an enantiomers separation process is selected. As the PDEs model exhibit a certain degree of singularity, wavelet collocation and high resolution methods are adopted for spatial discretisation. It is revealed that both the wavelet based approaches and high resolution methods are good candidates in terms of computation demand and prediction accuracy on the steep front. This is the first time that these two frontier numerical methods are used for such a complex SMB system models and our results are encouraging for the development of model-based online control scheme.
In developing a new scheme to rapidly obtain the solution at steady state for any arbitrary initial condition, the concept of Quasi-Envelope (QE) is adopted under the consideration that a SMBCP can be treated as a pseudo-oscillatory process because of a large number of continuous switching. The scheme allows larger steps to be taken to predict the slow change of starting state within each switching. Combined with previously developed wavelet-based technique, this method is successfully applied to the simulation of a SMB sugar separation process. Investigations are also carried out on the location of proper starting point for the algorithm and on the effect of changing stepsize to the convergence of iteration method. It is found that if the starting state of Quasi-Envelope is chosen to be the same as the original function, the multivalue algorithm would require similar computational effort to achieve the steady state prediction, regardless of the integration stepsize. If using constant stepsize, launching QE later is helpful when quasi-envelope displays steep change at the start-up period. A changing stepsize produces slow convergence compared to the constant stepsize strategy, thus increasing the work load where the stepsize change is occurring. Other iteration method is required to be imposed to achieve faster convergence right from the beginning. Potential applications can be seen for other chemical engineering processes with inherent cyclic behaviour.

Thesis (Ph.D.)--Royal Institute of Technology (Stockholm, Sweden), 2005.
"ISRN KTH/BKN/B-80-SE." "Dept. of Civil and Architectural Engineering, Division of Structural Design and Bridges, Royal Institute of Technology, Stockholm. " Includes bibliographical references. Available from the Royal Institute of Technology (Sweden) Library as a .pdf document http://www.lib.kth.se/main/eng/

碩士
元智大學
機械工程學系
95
In this study, the temperature effect on the reliability of the Flip Chip Ball Grid Array (FCBGA) component is investigated through combining experiment, finite element analysis (FEA) and the theoretical fatigue life calculation. The four-point bend test is conducted for the fatigue life of the FCBGA at various evaluated temperatures, namely 25℃, 75℃ and 100℃. During the tests, the daisy chain circuits, which link up all the solder balls of the component in series connection with certain initial resistance, are used for the checking up of the component failure. The surge in the resistance of the circuits are used as indices for the solder ball’s failure and the corresponding test cycle is then regarded as the fatigue life of the test component. After the tests, the failure mode analysis is introduced to observe the failure mechanism of the solder balls. For the finite element analysis, it is employed to simulate the FCBGA component when subjected to a cyclic bending load under specified temperatures. The resulted strains at the corner solder ball can then be used to estimate the fatigue life with the theoretical fatigue life model. The influence of the temperature effect on the reliability of component can be examined further by comparing the estimated fatigue life with the experimental fatigue life. It is found that the life of the FCBGA component at higher temperatures is less than that at lower temperatures. The failure locations are all observed to occur at the interface between bulk solder and printed circuit board. Besides, the accuracy of the fatigue life prediction with the quarter and the sliced finite element models is also examined. It indicates that the former is more accurate than the later in predicting the fatigue life. To summarize, the investigation offers an efficient way to evaluate the temperature effect on the reliability of the FCBGA component. It can provide the designer to have idea of the component life so that the reliability can be improved right at the design stage.

碩士
元智大學
機械工程學系
94
With the evolution of electronic technology, the electronic device becomes more complicate then ever before but with its size getting smaller and lighter. The development and application FCBGA component in the recent packaging industry is one of the measures to accommodate this trend. However, it is always inevitable that the electronic products will be subjected to some extent of external forces during manufacturing or customer use. To ensure the FCBGA components reliability becomes one of the crucial steps in improving the electronic products quality. This study use four-point cyclic bend test to check the reliability of FCBGA components with built in daisy chain. The failure modes are also inspected with the optics microscope. It is then combined with the FEM analysis, the crack length at failure is related to the fatigue-life and reliability by way of the fracture mechanics theory. Experimental results reveal that the location of solder ball crack varies with different the solder ball construction. Also, the stress intensity factors (SIF) are then diverged with the crack location and crack length. Finally, a model to predict the FCBGA fatigue life under the cyclic bend test is presented by employing the Paris Law. It is believed that the model can be applied for further components reliability study.

碩士
國立高雄師範大學
化學系
92
Three years ago, our teamwork has followed the procedures of Gray et. al.1 to synthesize the intermediate product 1Ch. We confirm that the compound 1Ch has mesophases, including the titled SmC phase2. But the compound 1Ch isn’t a liquid crystal, stated in the original paper. 2-phenyl ethyl group has been used by Gray et. al.3 as a terminal group, but no SmC phase was found in those compounds synthesized. Two years ago, we substituted the benzyl group of the 1Ch by 2-phenyl ethyl group to synthesize the compound 4Ch. It has the mesophases of SmC and N.4 In order to study the relationship between structure, including cyclic terminal group, hard core moiety and flexible chain length and the liquid crystalline behavior, we design and synthesize the following eight series of fifty-three compounds. Terminal 1-O-Core 1-CO2-Core 2-CO2-Terminal 2 Terminal 1 Core 1 Core 2 Terminal 2 編碼 CnH2n+1O- biphenyl phenyl -CH2-Ph n=1-10, 1Ca-1Cj CnH2n+1O- phenyl biphenyl -CH2-Ph n=1-10, 2Ca-2Cj CnH2n+1O- naphthalene phenyl Ph n=10, 3Cj CnH2n+1O- biphenyl phenyl -CH2-CH2-Ph n=1-10, 4Ca-4Cj Ph-CH2O- biphenyl phenyl CnH2n+1 n=1-10, 5Ca-5Cj CnH2n+1O- biphenyl phenyl -CH2-cyclobutane n=1-10, 6Ca-6Cj CnH2n+1O- biphenyl phenyl -CH2-cyclopropane n=8, 7Ch CnH2n+1O- biphenyl phenyl -CH2-CH2(OCH3)-Ph n=1-10, 8Ca-8Cj The results indicate that: most of them have SmA phase. While the short chain length favors the formation of N phase, the long chain length favors the formation of SmC phase. If a chiral methoxy group is induced to the cyclic terminal chain, it doesn’t influence the sequence of mesophases obviously. But instead of SmC phase, a SmC* phase is formed. They have Ps value ca.6-23 nC/cm2. Reference: 1. L. K. M. Chan, G. W. Gray, D. Lacey, R. M. Scrowston, L. G. Shenouda and K. J. Toyne, Mol. Cryst. Liq. Cryst., 1989, 172, 125-146. 2. 李惠貞，國立高雄師範大學化學所碩士論文，1999。 3. G. W. Gray and K. J. Harrison, Mol. Cryst. Liq. Cryst., 1971, 13, 37-60. 4. Wen-Liang Tsai, Hui-Chen Lee, Ming-Yung Hung, Li-Nien Chen, Mei-Yueh Hu, Fang-Ming Hsu, Liq. Cryst., 2004, 31, 301-302.