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Bibliografias temáticas / Dendrons

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Literatura científica selecionada sobre o tema "Dendrons"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de maio de 2024

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Artigos de revistas sobre o assunto "Dendrons"

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Hofacker, Amanda L., e Jon R. Parquette. "Amplification of local chirality within a folded dendrimer. An intramolecular ‘sergeants and soldiers’ experiment". Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 466, n.º 2117 (26 de agosto de 2009): 1469–87. http://dx.doi.org/10.1098/rspa.2009.0274.

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A series of pyridine-2,6-dicarboxamide dendrons having varying proportions of chiral and achiral termini have been prepared. Circular dichroism and X-ray crystallographic studies indicate that these folded dendrons propagate terminal chirality via a ‘sergeants and soldiers’ process. The extent of chiral amplification shows a dependence on dendron generation, but also is affected by the relative positioning of the chiral termini at the periphery of the dendron. Analysis of the crystal structures of the G1 dendrons, 4a – 6a , reveals chain–chain and chain–dendron conformational communication, which is likely to be responsible for the chiral amplification observed in solution.

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Zhao, Yanna, Jing Zhao, Chunying Hao, Meihua Han, Mincan Wang, Yifei Guo e Xiangtao Wang. "Self-assembled thermosensitive nanoparticles based on oligoethylene glycol dendron conjugated doxorubicin: preparation, and efficient delivery of free doxorubicin". RSC Advances 6, n.º 4 (2016): 2602–10. http://dx.doi.org/10.1039/c5ra22224a.

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Issa, Rahaf, Steve T. Meikle, Stuart L. James e Ian R. Cooper. "Use of Poly (ε-Lysine) Dendrons: A Strategy Targeting Bacterial Quorum Sensing and Biofilm Formation". Conference Papers in Science 2014 (11 de março de 2014): 1–8. http://dx.doi.org/10.1155/2014/572828.

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Pseudomonas aeruginosa is recognised as a major aetiological agent of nosocomial infections, which are associated with multiple-antibiotic resistance. Among many of its important virulence factors is its ability to form biofilms on the surfaces of implantable medical devices and to produce toxic metabolites, pyocyanin, via an intercellular cell density-dependent signalling system of communication. In this study, poly (ε-lysine) dendrons composed of increasingly branching generations were synthesised, characterised, and examined for their effects on virulence factor production in P. aeruginosa. The results show that these hyperbranched poly (ε-lysine) dendrons, in particular the 3rd generation, can increase the efficacy of a conventional antibiotic, ciprofloxacin, and reduce pyocyanin production, with marginal effects on the rate of bacterial replication, suggesting that the observed effects are not due to dendron toxicity. Furthermore, dendron and ciprofloxacin coadministration was identified as the most effective strategy which highlights the potential of peptide-based dendrons as quorum sensing inhibitors.

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Barkley, Deborah A., Sang Uk Han, Tadanori Koga e Jonathan G. Rudick. "Peptide–dendron hybrids that adopt sequence-encoded β-sheet conformations". Polymer Chemistry 9, n.º 40 (2018): 4994–5001. http://dx.doi.org/10.1039/c8py00882e.

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Meyhoff, Ulrich, Ulla Riber e Ulrik Boas. "Convergent synthesis of degradable dendrons based on l-malic acid". New Journal of Chemistry 39, n.º 2 (2015): 1161–71. http://dx.doi.org/10.1039/c4nj01156b.

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Shi, Da, Dinh-Vu Nguyen, Mounir Maaloum, Jean-Louis Gallani, Delphine Felder-Flesch e Marie Pierre Krafft. "Interfacial Behavior of Oligo(Ethylene Glycol) Dendrons Spread Alone and in Combination with a Phospholipid as Langmuir Monolayers at the Air/Water Interface". Molecules 24, n.º 22 (14 de novembro de 2019): 4114. http://dx.doi.org/10.3390/molecules24224114.

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Dendrons consisting of two phosphonate functions and three oligo(ethylene glycol) (OEG) chains grafted on a central phenoxyethylcarbamoylphenoxy group were synthesized and investigated as Langmuir monolayers at the surface of water. The OEG chain in the para position was grafted with a t-Bu end-group, a hydrocarbon chain, or a partially fluorinated chain. These dendrons are models of structurally related OEG dendrons that were found to significantly improve the stability of aqueous dispersions of iron oxide nanoparticles when grafted on their surface. Compression isotherms showed that all OEG dendrons formed liquid-expanded Langmuir monolayers at large molecular areas. Further compression led to a transition ascribed to the solubilization of the OEG chains in the aqueous phase. Brewster angle microscopy (BAM) provided evidence that the dendrons fitted with hydrocarbon chains formed liquid-expanded monolayers throughout compression, whilst those fitted with fluorinated end-groups formed crystalline-like domains, even at large molecular areas. Dimyristoylphosphatidylcholine and dendron molecules were partially miscible in monolayers. The deviations to ideality were larger for the dendrons fitted with a fluorocarbon end-group chain than for those fitted with a hydrocarbon chain. Brewster angle microscopy and atomic force microscopy supported the view that the dendrons were ejected from the phospholipid monolayer during the OEG conformational transition and formed crystalline domains on the surface of the monolayer.

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Enciso, Alan E., Giovanni Doni, Riccardo Nifosì, Ferruccio Palazzesi, Roberto Gonzalez, Amy A. Ellsworth, Jeffery L. Coffer et al. "Facile synthesis of stable, water soluble, dendron-coated gold nanoparticles". Nanoscale 9, n.º 9 (2017): 3128–32. http://dx.doi.org/10.1039/c6nr09679d.

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Hameau, Aurélien, Sabine Fuchs, Régis Laurent, Jean-Pierre Majoral e Anne-Marie Caminade. "Synthesis of dye/fluorescent functionalized dendrons based on cyclotriphosphazene". Beilstein Journal of Organic Chemistry 7 (28 de novembro de 2011): 1577–83. http://dx.doi.org/10.3762/bjoc.7.186.

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Functionalized phenols based on tyramine were synthesized in order to be selectively grafted on to hexachlorocyclotriphosphazene, affording a variety of functionalized dendrons of type AB5. The B functions comprised fluorescent groups (dansyl) or dyes (dabsyl), whereas the A function was provided by either an aldehyde or an amine. The characterization of these dendrons is reported. An unexpected behaviour of a fluorescent and water-soluble dendron based on dansyl groups in mixtures of dioxane/water was observed.

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Lu, Yao-Chih, Yu-Tsz Hsu, Tsung-Yen Yang, I.-Chun Liou, Sheng-Wei Wang, Po-Chia Huang, Jey-Jau Lee, Long-Li Lai e Hsiu-Fu Hsu. "Converting non-Mesogenic to Mesogenic Stacking of Amino-s-Triazine-Based Dendrons with p-CN Phenyl Unit by Eliminating Peripheral Dipole". Nanomaterials 12, n.º 2 (6 de janeiro de 2022): 185. http://dx.doi.org/10.3390/nano12020185.

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Three new amino-s-triazine-based dendrons, 1a, 1b, and 1c, containing an aryl-CN moiety in the dendritic skeleton were prepared in 72–81% yields (1a: R1 = − N(n-C8H17)2, R2 = n-OC8H17, 1b: R1 = R2 = − N(n-C8H17)2, 1c: R1 = − N(n-C8H17)2, R2 = − N(n-C4H9)2). Dendrons 1a with N(n-C8H17)2 and n-OC8H17 peripheral substituents, surprisingly, did not show any mesogenic phase during the thermal process. However, non-mesogenic 1a can be converted to mesogenic 1b or 1c by eliminating the peripheral dipole arising from the alkoxy substituent; dendron 1b only comprising the same N(n-C8H17)2 peripheral groups showed a ~25 °C mesogenic range on heating and ~108 °C mesogenic range on cooling. In contrast, dendron 1c possessing different N(n-CmH2m+1)2 (m = 8 versus m = 4) peripheral units, having similar stacking as 1b, exhibited a columnar phase on thermal treatment, but its mesogenic range (~9 and ~66 °C on heating and cooling, respectively) was much narrower than that of 1b, attributed to 1c’s less flexible alkyl chains in the peripheral part of dendron. Dendron 1a with the alkoxy substituent in the peripheral skeleton, creating additional dipole correspondingly, thus, leads to the dendritic molecules having a non-mesogenic stacking. Without the peripheral dipole for intermolecular side-by-side interaction, dendrons 1b and 1c exhibit a columnar phase on thermal treatment because of the vibration from the peripheral alkyl chain.

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Peyret, Ariane, John F. Trant, Colin V. Bonduelle, Khalid Ferji, Namrata Jain, Sebastien Lecommandoux e Elizabeth R. Gillies. "Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-l-glutamate)-glycosylated dendron hybrids". Polymer Chemistry 6, n.º 45 (2015): 7902–12. http://dx.doi.org/10.1039/c5py01060h.

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Polyester dendrons with peripheral α-galactose moieties were synthesized and coupled to poly(γ-benzyl-l-glutamate) to afford amphiphilic linear-dendron hybrid glycopolypeptides that self-assembled in water.

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Mais fontes

Teses / dissertações sobre o assunto "Dendrons"

1

Hardy, John George. "Dendrons for active ingredient formulation". Thesis, University of York, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437583.

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MARAVAL, VALERIE. "Synthese et applications de dendrons phosphores". Toulouse 3, 2000. http://www.theses.fr/2000TOU30090.

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Les dendrimeres sont des macromolecules arborescentes de structure definie preparees suivant deux voies de synthese : par la methode divergente, la synthese se fait du cur vers la peripherie de la molecule, et par la methode convergente, des fragments dendritiques appeles dendrons sont d'abord prepares puis assembles sur un cur plurifonctionnel. Les travaux presentes dans cette these portent sur l'elaboration de dendrons phosphores par une methode divergente et sur l'etude de leur reactivite. Le premier chapitre est une mise au point bibliographique sur les dendrons. Apres une description des differentes methodes de synthese de ces molecules et de leurs proprietes physicochimiques, la deuxieme partie concerne la preparation d'assemblages macromoleculaires par association de dendrons. Enfin, quelques exemples d'applications de ces molecules sont developpes. Dans le second chapitre, la synthese divergente de dendrons a cur fonctionnalise est decrite, ainsi que l'etude de la reactivite de la fonction vinylique composant le cur de l'un d'eux. Le chapitre iii porte sur l'utilisation du dendron precedemment etudie pour elaborer divers systemes multidendritiques originaux. Ceux-ci sont prepares par association de dendrons sur un metal ou sur un cur plurifonctionnel, ou encore par greffage de plusieurs dendrons sur un dendrimere central. Dans le chapitre iv, le meme dendron est utilise pour preparer des co-gels de silice et l'etude des materiaux formes est decrite. Le chapitre v porte sur la fonctionnalisation de surface de dendrimeres jusqu'a la sixieme generation par des clusters de fer. Enfin, le chapitre vi decrit l'utilisation en catalyse homogene de dendrimeres et de dendrons phosphores portant des complexes metalliques respectivement en surface et au cur. Leur activite catalytique a ete testee dans trois reactions et le probleme de la recuperation et de la reutilisation du catalyseur est egalement aborde.

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Al-Jamal, Khuloud Taysir Yousef. "Studies on cationic hydrophobic dendrons and hydrophilic dendrimers". Thesis, University College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414002.

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4

Preston, Sarah Suzanne. "Metal coordination directed folding of intramolecularly hydrogen-bonded dendrons". Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1135869971.

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5

Wyszogrodzka, Monika [Verfasser]. "New bifunctional polyglycerol dendrons for biomedical applications / Monika Wyszogrodzka". Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023582120/34.

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6

Preston, Sarah Suzanne. "Metal coordination directed folding of intramolecularly hydrogen-bonded dendrons". The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1135869971.

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7

Qiu, Jieru. "Dendrons phosphorés fluorescents amphiphiles : synthèse, caractérisation, applications en oncologie". Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30274.

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Les nanotechnologies ont le grand potentiel de révolutionner des technologies classiques variées, dû au développement de nombreux nanodispositifs et ont été intensément étudiées durant la dernière décade. Parmi les nanoparticules utilisées, les dendrimères et dendrons appartiennent à ce "nano-monde" en vertu de leur taille nanométrique, qui peut être modifiée à volonté, ainsi que par exemple leur multivalence et leurs charges. A l'intérieur de l'espace dendrimère, les dendrimères phosphorés apparaissent comme étant parmi les systèmes dendritiques les plus utiles, grâce à l'extraordinaire réactivité et adaptabilité de la chimie du phosphore. Dans ce mémoire nous décrivons la synthèse de plusieurs familles de dendrons phosphorés fluorescent amphiphiles potentiellement intéressants dans les domaines des nanomatériaux et de la nanomédecine. L'hexachlorocyclotriphosphazene utilisé comme cœur a été substitué par cinq groupements hydroxybenzaldehyde et un monomère tel que le pyrene ou un dérivé maleimide comme entité fluorescente ou l'azabisdimethylphosphonate comme groupement non fluorescent. Ces dendrons ont été préparés jusqu'à la génération 2 selon une voie divergente. La dernière étape a consisté en un greffage d'aminopyrrolidine ou aminopipéridine, suivi par protonation par HCl des groupements amines cycliques terminaux conduisant à la formation de dendrons phosphorés amphiphiles. La caractérisation physico-chimique a été réalisée par tout un ensemble de techniques : RMN, UV, CMC, diffusion dynamique de la lumière, potentiel zéta, microscopie électronique à transmission, fluorescence, dichroïsme circulaire, thermogravimétrie. L'étape suivante a consisté en l'étude des propriétés biologiques. Leur cytotoxicité a été déterminée en utilisant des tests MTT et Alamar Blue, effectués sur onze lignées cancéreuses ou saines (HL-60, HCT-116, A549, MCF7, PC3, U87, K562, K562R, MCR5, MDA-MB231 and HT-29). Des tests d'hémolyse ont été effectués pour tester l'effet des dendrons sur la membrane des cellules. Leur habilité à s'associer à du matériel génétique tels que les petits ARN interférents (siRNA siBCL-xL) a été mise en évidence par des expériences notamment d'électrophorèse sur gel. L'internalisation de ces associations (dendriplexes) dans les cellules tumorales a été suivie par cytométrie en flux. Dans le but de moduler les propriétés anticancéreuses des dendrons fluorescents amphiphiles, des quantum dots de carbone (CQDs) ont été associés avec les dendrons pyrene en présence d'un agent cytotoxique comme la doxorubicine encapsulée dans les micelles formées par les dendron pyrene et les CQDs. [...]
Nanotechnologies have the high potential to revolutionize various other classical technologies in many fields, due to the development of numerous nanodevice types, and have been intensively studied over the last decade. Among these nanoparticles, dendrimers and dendrons pertain to the "nano-world" by virtue of their size. Their nanometric sizes can be tailored as well, for instance, their multivalency and charges. Within the dendrimer space, phosphorus dendrimers and dendrons appear to be among the most useful dendritic systems due to the extraordinary reactivity and versatility of the phosphorus chemistry. In this thesis, we designed several families of original amphiphilic fluorescent phosphorus dendrons with interesting potential in the fields of nanomaterials and nanomedicine. Hexachlorocyclotriphosphazene used as a core was linked with five 4-hydroxybenzaldehyde and one monomer (pyrene and maleimide derivatives as fluorescent monomers and azabisdimethylphosphonate derivatives as non-fluorescent monomer). The dendrons were prepared up to generation 2 by a divergent method. The last step is the grafting of amino pyrrolidine or amino piperidine following by protonation with HCl to get the expected cationic amphiphilic fluorescent phosphorus dendrons. Their physical characterization were evaluated through numerous technics: NMR, UV, critical micelle concentration (CMC), dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), fluorescent spectra, circular dichroism and thermogravimetry. In a next step, the biological properties of the dendrons have been examined. The cytotoxicity of dendrons was determined using MTT test and Alamar Blue assay performed on eleven cells lines including both cancer cells and healthy cells (HL-60, HCT-116, A549, MCF7, PC3, U87, K562, K562R, MCR5, MDA-MB231 and HT-29 cells line). Hemolysis assays were used to test the effect of dendrons on the cell membrane. Their ability to bind genetic material was studied by gel electrophoresis using fluorescein-labeled small interference RNA siBCL-xL. Flow cytometry method was used to study the internalization of dendriplexes into tumor cells. In order to modulate the anticancer properties of the fluorescent dendrons, carbon quantum dots (CQDs) were chosen to conjugate with the pyrene dendrons in the presence of a cytotoxic agent like doxorubicin (DOX), physically loaded into 'micelles'. [...]

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Chen, Liang. "Synthèse et applications biologiques de dendrimères et dendrons phosphorés". Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30277.

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L'objectif de ces travaux était de concevoir plusieurs familles de dendrimères phosphorés cationiques et de dendrons neutres et cationiques, et d'étudier leur potentiel dans le domaine de la biologie/nanomédecine. Premièrement, nous avons revisité les dendrimères phosphorés cationiques comme vecteur non viral pour le transport de gènes contre le cancer. L'efficacité d'expression des gènes a été détectée par microscopie à fluorescence, cytométrie en flux, réaction en chaîne de polymérase quantitative en temps réel (rt-qPCR) et tests Western blot. Les résultats révèlent que dans les conditions optimisées, la transfection de l'ADNp induit l'expression significative de la protéine p53 comme montré par l'arrêt du cycle cellulaire résultant (régulation de p21 et de l'expression de Cdk4/Cyclin-D1) et le Western blot. De plus, le potentiel en thérapie génique du cancer des polyplexes a finalement été validé sur un modèle tumoral de xénogreffe après injection intra-tumorale, sans toxicité systémique. Au vu de tous les résultats déjà obtenus, l'utilisation de dendrimères phosphorés cationiques pour la biologie est sans aucun doute très prometteuse pour l'avenir. Deuxièmement, les dendrons phosphorés complexant Cu(II) et Au(III) (génération 1) portant 10 Cu(II)Cl2 ou [Au(III)Cl2]+ à leur surface, et des chaînes alkyle en C11 et C17 ont été synthétisées. Ces dendrons ont montré une activité antiproliférative significative contre les lignées cellulaires cancéreuses telles que 4T1 et MCF-7 (cancer du sein). Les meilleurs résultats concernant l'activité antiproliférative pour tuer les cellules cancéreuses ont été obtenus avec les complexes de dendrons Au(III) portant une courte chaîne alkyle. L'analyse de la voie de mort cellulaire révèle que les complexes de dendrons pourraient modifier l'état des protéines liées au cycle cellulaire et à l'apoptose, entraînant un arrêt de la phase S du cycle cellulaire et une apoptose. En particulier, les complexes de Au(III) ont induit une létalité cellulaire dépendante de la caspase, en favorisant la translocation de Bax vers les mitochondries et la libération de Cyto C, tandis que les complexes de Cu(II) sont de faibles activateurs de la caspase-3, en lien avec leur activité antiproliférative modérée dans les cellules cancéreuses. Ses études dans leur ensemble ont montré que ces complexes de dendrons phosphorés originaux représentent une nouvelle classe de nano-médicaments anticancéreux, et leur développement ouvrira de nouvelles voies pour lutter contre les cancers. Enfin, nous avons préparé le dendron phosphoré amphiphile 1-C12G1 portant une longue chaîne alkyle linéaire (C12H25), et dix groupes pyrrolidine protonés en surface. Le 1-C12G1 forme des nanomicelles qui permettent d'encapsuler le médicament anticancéreux DOX et de complexer l'inhibiteur miR-21. [...]
The aim of this work was to design several families of cationic phosphorus dendrimers and of neutral and cationic dendrons, and to investigate their potential in the field of biology/nanomedicine. Firstly, we revisited the cationic phosphorus dendrimers as a non-viral vector for gene delivery towards cancer therapy. The expression efficiency of genes was detected by fluorescence microscopy, flow cytometry, quantitative real time polymerase chain reaction (rt-qPCR) and Western blot assays. The results reveal that under the optimized conditions, the transfection of pDNA induces the significant p53 protein expression as verified through the resulting cell cycle arrest (regulation of p21 and Cdk4/Cyclin-D1 expression) and Western blotting. Moreover, the cancer gene therapy potential of the polyplexes was finally validated through therapy of a xenografted tumor model after intra-tumoral injection without systemic toxicity. In view of all the results already obtained, undoubtedly the use of cationic phosphorus dendrimers for biology holds great promises for the future. Secondly, the first-in-class Cu(II) and Au(III) metaled phosphorus dendrons (generation 1) bearing 10 Cu(II)Cl2 or [Au(III)Cl2]+ on their surface, and with C11 and C17 linear alkyl chains were synthesized. These dendrons showed significant antiproliferative activity against cancer cell lines such as 4T1 and MCF-7 (breast cancer). The best results concerning the antiproliferative activity to kill cancer cells were obtained with the Au(III) dendron complexes bearing short alkyl chain length. Cell death pathway analysis reveals that the metaled dendrons could alter the cell cycle- and apoptosis-related protein status of cells, resulting in cell cycle S-phase arrest and apoptosis. In particular, Au(III)-complexes induced the caspase-dependent cellular lethality by promoting the translocation of Bax to the mitochondria and the release of Cyto C, whereas the Cu(II)-complexes are weak activators of caspase-3, in line with their moderate antiproliferative activity in cancer cells. Taken together, these studies showed that these first-in-class metaled phosphorus dendrons represent a novel class of anticancer nanodrugs, and their development will open new avenues to tackle cancers. Lastly, we prepared the amphiphilic phosphorus dendron 1-C12G1 bearing a long linear alkyl chain (C12H25), and bearing ten protonated pyrrolidine groups in the surface. 1-C12G1 forms nanomicelles which allow to encapsulate anticancer drug DOX and complex the miR-21 inhibitor. Especially, the encapsulation efficiency of DOX can reach up to 83.60%. Meanwhile, gel retardation assay showed that the miR-21i complexed by 1-C12G1@DOX were protected from degradation for up to 12 h and 24 h compared to the naked miR-21i.[...]

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Aloisi, Adriano. "Nanoparticles based on different generation adamantane dendrons : design, synthesis and self-assembly studies". Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF062.

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L’adamantane est un hydrocarbure polycyclique, rigide et assez encombrant. En médecine, plusieurs dérivés à base d’adamantane ont été développés notamment comme agent antiviraux. Facilement fonctionnalisés, sa conformation 3D permet d’amoindrir les encombrements stériques entre les différents groupements fonctionnels. Nous avons décidé d’utiliser ses propriétés pour concevoir des structures plus complexes, à savoir, des dendrons et des foldamers. Les dendrons sont des polymères synthétiques possédant des propriétés intéressantes. De par leurs tailles, ils sont considérés comme des nanoparticules et possèdent un ciblage passif des cellules cancéreuses. De plus, facilement fonctionnalisés ils peuvent être utilisés comme molécule cargo dans la vectorisation de principes actifs. Outre la vectorisation, les dendrons permettent d’améliorer les propriétés physico-chimiques d’un médicament (absorption, distribution, métabolisme, élimination et toxicité). Nous avons alors choisi de concevoir des dendrons à base d’adamantane. Ces derniers ont la particularité de ne pas posséder d’espaceur entre les molécules d'adamantane se qui les rend hautement rigides. L’analyse par microscopie électronique à transmission de différents dendrons a permis d’étudier leurs morphologies selon leurs fonctionnalisations ainsi que l’effet du solvant, de la concentration et du support sur leurs auto-assemblages. Dans un second temps, nous avons conçu un acide aminé basé sur l’adamantane. Cet acide g-aminé a ensuite été incorporé dans des séquences peptidiques et les effets de l’adamantane sur la structure secondaire des peptides ont été étudiés par dichroïsme circulaire
Adamantane is a polycyclic hydrocarbon, rigid and quite bulky. In medicine, several adamantane-based derivatives have been developed especially as antiviral agents. Easily functionalized, its 3D well-defined structure considerably decrease the sterical hindrance between its different functional groups. In this context, we decided to use adamantane to build more complex structures such as dendrons and foldamers. Dendrons are synthetic polymers with interesting properties. Because of their size, they are considered as nanoparticles and possess a passive cancer cell targeting. In addition,they are easily functionalized and can be use as vector of drugs. Indeed, the dendrons improve the physochemical properties of a drug (absorption, distribution, metabolism, elimination and toxicity). We decided to combine adamantane and dendrons to build adamantane-based dendrons. However, these dendrons have the particularity of not having spacer between the adamantane moieties, thus, they are highly rigid. Transmission electron microscopy analysis of the different functionalized dendrons allowed to study their self-assembly capacity and their morphology according to their functional groups,the solvent, the concentration and the support. In a second step, we designed an amino acid based on adamantane. This g-amino acid has been introduced in a peptide backbone using solid phase peptide synthesis. Then, the effects of adamantane onto peptide secondary structures have been studied by circular dichroism

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10

Fransen, Peter. "Synthesis and versatile applications of oligoethylene glycol dendrons using click chemistry". Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/131404.

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Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the interior is made of branching units and the void space in between the branched. Interesting properties of dendrimers are monodispersity, multivalency and a globular geometry. Click chemistry is a ‘set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries’. The most commonly used click reaction is the copper-catalyzed azide-alkyne cycloaddition (CuAAC). Click chemistry is a powerful tool for the construction and functionalization of dendrimers. The principle objective of the present thesis is the use of click chemistry for the synthesis of higher generation dendrons and exploring the possible use of these dendrons for biomedical applications. The first generation dendrons which were synthesized in this work consist of two distinct parts: 1) a core unit derived from the acid diethylene triamine pentaacetic acid (DTPA); 2) monodisperse chains of oligoethylene glycol (OEG) of exact length which are coupled to the DTPA core unit by amide bond formation. The second and third generation dendrons were obtained in two steps: 1) conversion of the surface functional groups to azides; 2) coupling the azide building block unit to the azides of the core unit through CuAAC. Apart from the synthesis of the dendrons using click chemistry, the present thesis also described some biomedical applications of the mentioned dendrons. The core unit derived from DTPA is orthogonally protected and this allows functionalizing the dendrons with distinct moieties. Furthermore, the DTPA derivative endows the dendrons the intrinsic capability to chelate metal ions. The chelation depends on the type of complexated metal ion and also on the functional group in the focal point of the dendron. The metals which can be chelated include gadolinium, terbium and indium, all of which are interesting for medical imaging purposes. Chelating gadolinium with dendrons increase the relaxivity induced by the gadolinium ion because the size of the dendrons slows down the rotation of the metal center. Also, the relaxivity is increased due to the hydrophilic character of the dendrons. Combining the ability to chelate with the multivalency of the dendrons several multimodal platforms for medical imaging were constructed. The platforms were functionalized with targeting peptides and a fluorophore and the DTPA derived core unit carried an isotope of indium. Internalization assays demonstrated that the peptides were able to direct the platforms towards the targeted cells and other preliminary in vivo experiments indicated that the constructs accumulated in the tumors as shown in fluorescence and SPECT imaging. Other dendrons were synthesized to serve as cross-linking agents of bio functionalization platforms. The cross-linking agents were composed of four azides and one bioactive moiety and are used to form hydrogels with the biopolymer hyaluronic acid. The biofunctionalization platforms were composed of four peptides and one azide for coupling the dendron. Using these platforms, peptides sequences could be introduced into the hydrogel and this works to augment the viability of the implanted cells. Finally, an OEG-based dendron was used in combination with carbosilane dendrons to construct hybrid dendrons to bind DNA. The hybrid molecules displayed less cytotoxicity and were more effective delivering genetic material. In conclusion, it has been demonstrated that click chemistry is a powerful tool for the synthesis and versatile applications of OEG-based dendrons.
Los dendrímeros son una clase de macromoléculas que se caracterizan por tener una estructura altamente ramificada. Los dendrímeros contienen una superficie multivalente con los grupos funcionales, un núcleo donde empieza la ramificación eun interior constituido por los puntos de ramificación y los espacios vacíos entre las ramas. Las propiedades más interesantes de los dendrímeros incluyen su monodispersidad, multivalencia y geometría globular. La química click es un ¿grupo de reacciones que son poderosas, fiables y selectivas para la síntesis rápida de compuestos útiles y bibliotecas combinatorias¿. El mejor ejemplo de química click es la cicloadición catalizada por cobre entre azidas y alquinos (CuAAC). La química click es una herramienta poderosa para construir y funcionalizar dendrimeros. El objetivo principal de la presente tesis ha sido utilizar la química click para la síntesis de dendrones de generaciones elevadas y explorar la posibilidad de aplicar estos dendrones para aplicaciones biomédicas. Los dendrones de primera generación sintetizados en este trabajo consisten de dos partes distintas: 1) un núcleo derivado del ácido dietilentriaminopentaacético (DTPA); 2) unas ramas monodispersas de oligoetilenglicol (OEG) que se acoplan al núcleo de DTPA a través de la formación de un enlace amida. Los dendrones de generación 2 y 3 se pueden obtener mediante dos pasos: 1) la conversión de grupos funcionales en la superficie a azidas; 2) acoplando el building block dendron con un alquino a la azida a través de la CuAAC. Aparte de la síntesis de los dendrones utilizando la química click, la presente tesis también describe unas aplicaciones biomédicas de estos dendrones. El núcleo basado en DTPA está protegido de una manera ortogonal y esto permite funcionalizar los dendrones con grupos distintos. El derivado de DTPA también otorga a los dendrones una capacidad intrínseca de complejar iones de metales. La complejación depende del tipo de metal complejado y del grupo funcional en el punto pocal del derivado de DTPA. Los metales que se complejan incluyen gadolinio, terbio e indio, los cuales son interesantes para aplicaciones de imagen médica. Complejando gadolinio los dendrones aumentan la relaxividad causado por el ion de gadolinio porque el tamaño mayor de dendron ralentiza la rotación del metal. También la relaxividad se aumenta por el carácter hidrófilo de los dendrones. Combinando la capacidad de quelar con la multivalencia del dendron se construyeron distintas plataformas multimodales para la imagen médica. Las plataformas se funcionalizaron con péptidos diriguidores y un fluoroforo y el nucleo basado en DTPA llevaba un isotopo de indio. Ensayos de internalización mostraron que los péptidos eran capaces de dirigir las plataformas a las células dianas y unos experimentos preliminares in vivo indicaron que los constructos se acumularon en tumores lo cual se podía visualizar por fluorescencia y por SPECT. Se sintetizaron dendrones como agentes de cross-linking o plataformas de biofuncionalizacion. Los agentes de cross-linking llevan cuatro azidas y un grupo bioactivo y sirve para formar un hidrogel con el biopolímero acid hyaluronico. Las plataformas de biofuncionalizacion tienen cuatro péptidos y una azida para acoplar el dendron al biopolímero. Así se pueden introducir grupos peptídicos en el hidrogel y esto sirve para aumentar la viabilidad de las células implantadas Finalmente se utilizaron los dendron de OEG en conjunto con dendrones de carbosilano para preparar dendron híbridos para complejar ADN. Estos hibridos mostraron menos citotixicad y tenían una mayor capacidad de entregar material genético. En conclusión, se ha mostrado que la química click es una herramienta potente para la síntesis y aplicación diversa de dendrones basados en OEG.

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Mais fontes

Livros sobre o assunto "Dendrons"

1

N, Moorefield C., e Vögtle F. 1939-, eds. Dendrimers and dendrons: Concepts, syntheses, applications. Weinheim: Wiley-VCH, 2001.

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2

Tomalia, Donald A. Dendrimers, dendrons, and dendritic polymers: Discovery, applications, and the future. Cambridge: Cambridge University Press, 2012.

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3

Polemi: Genealogiko dendro. Leukōsia: Ekdoseis Epiphaniou, 2007.

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4

Saunders, Kate Marie. Silurian dendroid graptolites: Taxonomy, palaeoecology and biostratigraphy. Portsmouth: University of Portsmouth, School of Earth and Environmental Sciences, 2001.

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5

Hena klōnari apo to megalo dendro tēs Cheimarras. Athēna: Ekdotikos Oikos Angelakē, 2013.

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6

Kantēs, Panagiōtēs Christou. Ereuna gia to genealogiko dendro koinotētas Hagiou Iōannē Malountas. Leukōsia: [s.n.], 2006.

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7

Mannen, Hajime. A dendro-cyto-myeloarchitectonic atlas of the cat's brain. Tokyo: Iwanami Shoten, 1988.

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8

Treydte, Kerstin Susanne. Dendro-Isotope und Jahrringbreiten als Klimaproxis der letzten 1200 Jahre im Karakorumgebirge/Pakistan. Jülich: Forschungszentrum Jülich, Zentralbibliothek, 2003.

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9

wales, Business Connect North, ed. Sut i dendro?: Canllawiau i gwmnïau ar gynnig tendrau i'r sector gyhoeddus = How to tender? : guidelines to companies tendering to the public sector. [s.l.]: Cyswllt Busnes Gogledd Cymru = Business Connect North Wales, 1999.

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10

1735-1807, Benizelos Iōannēs ca, Voulismas Dōrotheos e Kentron Ereunēs tou Mesaiōnikou kai Neou Hellēnismou (Akadēmia Athēnōn), eds. Hē "Didaskalia Christianikē kat' erōtapokrisin" agnoēmeno autographo ergo (1780) tou Iō. Benizelou: Hē allēlographia tou syngraphea (1780-82) me to Dōrotheo Voulēsma kai hē idiopoiēsē kai ekdosē tou ergou (1841) apo ton Prokopio Dendrino. Athēna: Akadēmia Athēnōn, Kentro Ereunēs tou Mesaiōnikou kai Neou Hellēnismou, 1990.

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Capítulos de livros sobre o assunto "Dendrons"

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Caminade, Anne-Marie. "Syntheses of Dendrimers and Dendrons". In Dendrimers, 1–33. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119976530.ch1.

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Kawa, Manabu. "Antenna Effects of Aromatic Dendrons and Their Luminescence Applications". In Topics in Current Chemistry, 193–204. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/b11011.

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3

Laurini, Erik, Suzana Aulic, Natasa Skoko, Domenico Marson, Maurizio Fermeglia e Sabrina Pricl. "ITC for Characterization of Self-Assembly Process of Cationic Dendrons for siRNA Delivery". In Methods in Molecular Biology, 245–66. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1298-9_15.

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4

Fréchet, J. M. J., H. Ihre e M. Davey. "Preparation of ‘Fréchet-type’ Polyether Dendrons and Aliphatic Polyester Dendrimers by Convergent Growth: An Experimental Primer". In Dendrimers and Other Dendritic Polymers, 567–86. Chichester, UK: John Wiley & Sons, Ltd, 2002. http://dx.doi.org/10.1002/0470845821.ch24.

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Sabidussi, G. "Dendroids, End-Separators, and Almost Circuit-Connected Trees". In Cycles and Rays, 221–36. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0517-7_17.

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Rogosin, Sergei, e Tatsyana Vaitekhovich. "Hele-Shaw Model for Melting/Freezing with Two Dendrits". In Materials Science Forum, 143–51. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-438-3.143.

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Costa, Lázaro, e João Rocha da Silva. "Dendro: A FAIR, Open-Source Data Sharing Platform". In Digital Libraries for Open Knowledge, 384–87. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-30760-8_39.

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Advincula, Rigoberto C., e Maria Celeste Tria. "Design and Synthesis of Living-Free Electroactive Dendron End-Functionalized Macromolecules: Surface Grafting Studies". In ACS Symposium Series, 63–72. Washington, DC: American Chemical Society, 2010. http://dx.doi.org/10.1021/bk-2010-1050.ch005.

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Hatton, Fiona L. "Mixing Dendron and PEG Initiators for the Polymerisation of Branched pHPMA and Aqueous Nanoparticle Formation". In Springer Theses, 79–116. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18753-2_3.

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Rocha da Silva, João, João Aguiar Castro, Cristina Ribeiro e João Correia Lopes. "Dendro: Collaborative Research Data Management Built on Linked Open Data". In Lecture Notes in Computer Science, 483–87. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-11955-7_71.

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Trabalhos de conferências sobre o assunto "Dendrons"

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Šutý, Šimon, Veronika Oravczová, Maksim Ionov, Dzmitry Shcharbin, Jean-Pierre Majoral, Zuzana Šimoníková, Tibor Hianik, Maria Bryszewska e Iveta Waczulíková. "Blood compatibility of originally synthesized amphiphilic dendrons". In 1st International Electronic Conference on Biomedicine. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecb2021-10285.

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2

Pan, Hongmu, e Marie-Christine Daniel. "Studies of MRI relaxivities of gadolinium-labeled dendrons". In SPIE Defense, Security, and Sensing, editado por Brian M. Cullum e Eric S. McLamore. SPIE, 2011. http://dx.doi.org/10.1117/12.885271.

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3

Jen, Alex K. Y., Jingdong Luo, Hong Ma, Marnie Haller, Richard R. Barto e Curtis W. Frank. "Dendritic NLO chromophore with fluorinated dendrons for improving poling efficiency in electro-optic devices". In International Symposium on Optical Science and Technology, editado por Guozhong Cao e Wiley P. Kirk. SPIE, 2002. http://dx.doi.org/10.1117/12.451672.

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4

Ashworth, Kimba, Charles W. Spangler e Benjamin Reeves. "Model dendrons and dendrimers incorporating diphenylamino-substituted diphenylpolyene and PPV-oligomer moieties for NLO applications". In SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, editado por Manfred Eich e Mark G. Kuzyk. SPIE, 1999. http://dx.doi.org/10.1117/12.368271.

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5

Pan, Jianfeng, Weihong Zhu, Shangfeng Li e He Tian. "Dendron-functionalized perylenes for red luminescent materials". In Photonics Asia 2004, editado por Gang Yu, Chuangtian Chen e Changhee Lee. SPIE, 2005. http://dx.doi.org/10.1117/12.600899.

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Pearson, R. M., Jin Woo Bae, S. Sunoqrot, S. Uddin e Seungpyo Hong. "Facilitated self-assembly of novel dendron-based copolymers". In 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2011. http://dx.doi.org/10.1109/iembs.2011.6092055.

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7

Weaver, Bryn M., e Harsha Wickramasinghe. "Dendro: Biomass Power From, By, and For the People of Sri Lanka". In ASME 2006 International Solar Energy Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/isec2006-99068.

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Sri Lanka’s power crisis presents considerable challenges and opportunities as attempts are made to electrify the remaining 30% of non-grid connected areas and generate reliable power in a sustainable manner. Fifty percent of the energy needs in the country are being met with biomass, 70% of these are domestic rural users. Meeting Sri Lanka’s ever-growing electricity demand with fossil fuel imports is siphoning off 30% of export earnings annually. Biomass based electricity generation, commonly referred to as dendro power, has emerged as the most sustainable option in Sri Lanka to meet spiking demand. The Sri Lankan government’s Inter-Ministerial Working Committee (IMWC) on Electricity Generation from Biomass through Dendro Thermal Technology has developed a dendro thermal program whose salient feature is to add 100 MW of dendro capacity to the grid by 2010. Energy plantations of the woody plant, Gliricidia sepium, would extend over 200,000 hectares of land currently considered to be waste cropland. Income opportunities are expected for 100,000 families if the program is successful. Dendro, as a carbon-neutral source, offers a dual-purpose vehicle for rural citizens to be benefited with income and energy. The dendro program aims to supply grid, off-grid, rural industrial and household energy. This national program could result in significant environmental benefits, opportunities for poverty alleviation and support mechanisms for traditional rural industries. This report is a summary of IMWC’s Dendro Thermal Program, focusing on income avenues and economic impacts.

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Sedlacik, Michal, Tomas Plachy e Daniela Vaclavkova. "The surface modification of magnetic particles with polyamidoamine dendron". In RECENT ADVANCES ON ENVIRONMENT, CHEMICAL ENGINEERING AND MATERIALS. Author(s), 2018. http://dx.doi.org/10.1063/1.5060699.

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Nienhaus, Lea, e Martin Gruebele. "ENERGY TRANSFER IN A SYNTHETIC DENDRON-BASED LIGHT HARVESTING SYSTEM". In 69th International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2014. http://dx.doi.org/10.15278/isms.2014.th07.

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Wulf, Verena, Parul Rathee, Gadi Slor, Roey J. Amir e Gili Bisker. "Dendron-polymer hybrids as tailorable coronae of single-walled carbon nanotubes". In Label-free Biomedical Imaging and Sensing (LBIS) 2022, editado por Natan T. Shaked e Oliver Hayden. SPIE, 2022. http://dx.doi.org/10.1117/12.2608179.

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Relatórios de organizações sobre o assunto "Dendrons"

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Merchant, Bion John. The GNEMRE Dendro Tool. Office of Scientific and Technical Information (OSTI), outubro de 2007. http://dx.doi.org/10.2172/926809.

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Arias, Eduardo, Ivana Moggio e Ronald Ziolo. Liquid Crystals of Dendron-Like Pt Complexes Processable Into Nanofilms Dendrimers. Phase 2. Cholesteric Liquid Crystal Glass Platinum Acetylides. Fort Belvoir, VA: Defense Technical Information Center, agosto de 2014. http://dx.doi.org/10.21236/ada619975.

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