Bibliografias temáticas / Diabetic neuropathies

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Literatura científica selecionada sobre o tema "Diabetic neuropathies"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 1 de agosto de 2024

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Artigos de revistas sobre o assunto "Diabetic neuropathies"

Bogdanov, E. I., V. V. Talantov e R. Z. Mukhamedzyanov. "Diabetic neuropathies". Neurology Bulletin XXXII, n.º 3-4 (15 de julho de 2000): 59–67. http://dx.doi.org/10.17816/nb79487.

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Diabetic neuropathies (DN) are among the most frequent and serious complications of diabetes [57, 9]. The detection rate of DN in diabetic patients varies greatly depending on their type, selected clinical and instrumental diagnostic criteria and, according to various researchers, ranges from 10 to 90% [16, 33]. At the same time, 1/3 of the polyneuropathies recognized in the neurological clinic are diabetic. In about 10% of cases, neuropathic symptoms are key in the diagnosis of diabetes [25]. DN has not only severe subjective manifestations and pronounced impairments that are objectively detected in them, but also leads to the development of diabetic foot syndrome - the cause of 50 - 70% of cases of all non-traumatic amputations of the legs [3]. In addition, in patients with diabetic visceral autonomic neuropathy, the syndrome of "sudden death" is much more common, and the frequency of painless myocardial infarctions and ischemic strokes is high. Clinical variants of DN are often the main causes of reduced quality of life, disability and disability in patients with diabetes mellitus. It is extremely important to diagnose the early stage of DN, when it is easier to achieve a therapeutic effect through the earliest and most stable provision of optimal control of an adequate level of glycemia and the appointment of means of pathogenetic therapy. Isolation of forms of DN, their diagnosis, treatment and prevention is an urgent clinical task.

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Elafros, Melissa A., e Brian C. Callaghan. "Diabetic Neuropathies". CONTINUUM: Lifelong Learning in Neurology 29, n.º 5 (outubro de 2023): 1401–17. http://dx.doi.org/10.1212/con.0000000000001291.

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ABSTRACT OBJECTIVE This article provides an up-to-date review of the diagnosis and management of the most common neuropathies that occur in patients with diabetes. LATEST DEVELOPMENTS The prevalence of diabetes continues to grow worldwide and, as a result, the burden of diabetic neuropathies is also increasing. Most diabetic neuropathies are caused by hyperglycemic effects on small and large fiber nerves, and glycemic control in individuals with type 1 diabetes reduces neuropathy prevalence. However, among people with type 2 diabetes, additional factors, particularly metabolic syndrome components, play a role and should be addressed. Although length-dependent distal symmetric polyneuropathy is the most common form of neuropathy, autonomic syndromes, particularly cardiovascular autonomic neuropathy, are associated with increased mortality, whereas lumbosacral radiculoplexus neuropathy and treatment-induced neuropathy cause substantial morbidity. Recent evidence-based guidelines have updated the recommended treatment options to manage pain associated with distal symmetric polyneuropathy of diabetes. ESSENTIAL POINTS Identifying and appropriately diagnosing the neuropathies of diabetes is key to preventing progression. Until better disease-modifying therapies are identified, management remains focused on diabetes and metabolic risk factor control and pain management.

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Alalwee, Azza, Jonathan D. LeSar, Mina Ghassemi, Eugene Cheng, Steven Stuto, Lawrence Osher, Scott Bastian, Vincent J. Hetherington e Jill Kawalec. "Foot Temperature Trends in Normal, Diabetic, and Neuropathic Foot Populations". Journal of the American Podiatric Medical Association 106, sp1 (1 de janeiro de 2016): 5. http://dx.doi.org/10.7547/8750-7315-2016.1.alalwee.

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INTRODUCTION AND OBJECTIVES: Patients with underlying peripheral neuropathy are subject to changes in foot temperature. (1,2) Of the many forms of neuropathy that affect the lower extremity, the most notable are those types associated with diabetes. The aim of this study was to look for differences in temperatures between uncomplicated diabetic, diabetic neuropathic, and non-diabetic neuropathic feet. METHODS: The feet of 75 subjects were divided into 3 groups: 1) normal (n=50 feet), 2) diabetic (n=50 feet), and 3) neuropathic (n=49 feet). The neuropathic group was further subdivided into diabetic neuropathies (n=20 feet) and non-diabetic neuropathies (n=29 feet). To properly assign subjects to groups, all participants underwent vibratory threshold testing with a biothesiometer. In addition, all diabetic subjects had added glycosylated hemoglobin (hemoglobin A1C) studies performed. Temperature measurements were recorded at nine distinct foot locations (six plantar and three dorsal). Data was statistically analyzed using the Kruskal-Wallis test. RESULTS: For five of the plantar pedal sites tested, temperatures in the diabetic foot were significantly greater than those for the normal controls (p<0.05). At most sites, temperatures in the diabetic foot population tended to be higher than those in both diabetic and non-diabetic neuropathic feet, with the differences between the diabetic foot and non-diabetic neuropathic foot being statistically significant at one dorsal and five plantar sites. Patients in the non-diabetic neuropathic group were not stratified according to their specific neuropathic types. CONCLUSIONS: Diabetic feet, with and without neuropathy, tend to be warmer than the feet of patients with other non-diabetic neuropathies. The finding of no statistical difference between non-neuropathic diabetic and neuropathic diabetic feet is unexpected in that a number of these patients were projected to have an autonomic system component. These null findings suggest the need to further investigate neuropathy solely determined by sensory testing versus tests for autonomic system involvement.

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Fisher, Morris A., Vijaya K. Patil e Charles L. Webber. "Recurrence Quantification Analysis of F-Waves and the Evaluation of Neuropathies". Neurology Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/183608.

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Electrodiagnostic (EDX) patterns of neuropathic dysfunction have been based on axonal/demyelinating criteria requiring prior assumptions. This has not produced classifications of desired sensitivity or specificity. Furthermore, standard nerve conduction studies have limited reproducibility. New methodologies in EDX seem important. Recurrent Quantification Analysis (RQA) is a nonlinear method for examining patterns of recurrence. RQA might provide a unique method for the EDX evaluation of neuropathies. RQA was used to analyze F-wave recordings from the abductor hallucis muscle in 61 patients with neuropathies. Twenty-nine of these patients had diabetes as the sole cause of their neuropathies. In the other 32 patients, the etiologies of the neuropathies were diverse. Commonly used EDX variables were also recorded. RQA data could separate the 29 patients with diabetic neuropathies from the other 32 patients (P<0.009). Statistically significant differences in two EDX variables were also present: compound muscle action potential amplitudes (P<0.007) and F-wave persistence (P<0.001). RQA analysis of F-waves seemed able to distinguish diabetic neuropathies from the other neuropathies studied, and this separation was associated with specific physiological abnormalities. This study would therefore support the idea that RQA of F-waves can distinguish between types of neuropathic dysfunction based on EDX data alone without prior assumptions.

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Said, Gérard. "Focal and multifocal diabetic neuropathies". Arquivos de Neuro-Psiquiatria 65, n.º 4b (dezembro de 2007): 1272–78. http://dx.doi.org/10.1590/s0004-282x2007000700037.

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Diabetic neuropathy is the most common neuropathy in industrialized countries, with a remarkable range of clinical manifestations. The vast majority of the patients with clinical diabetic neuropathy have a distal symmetrical form that progress following a fiber-length dependent pattern, with predominant sensory and autonomic manifestations. This pattern of neuropathy is associated with a progressive distal axonopathy. Patients are exposed to trophic changes in the feet, pains and autonomic disturbances. Less often, diabetic patients may develop focal and multifocal neuropathy that includes cranial nerve involvement, limb and truncal neuropathies. This neuropathic pattern tends to occur after 50 years of age, mostly in patients with longstanding diabetes mellitus. The LDDP does not show any trend to improvement and either relentlessly progresses or remain relatively stable over years. Conversely the focal diabetic neuropathies, which are often associated with inflammatory vasculopathy on nerve biopsies, remain self limited, sometimes after a relapsing course.

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Kazamel, Mohamed, e Peter J. Dyck. "Sensory manifestations of diabetic neuropathies: Anatomical and clinical correlations". Prosthetics and Orthotics International 39, n.º 1 (22 de janeiro de 2015): 7–16. http://dx.doi.org/10.1177/0309364614536764.

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Background: Diabetes mellitus is among the most common causes of peripheral neuropathy worldwide. Sensory impairment in diabetics is a major risk factor of plantar ulcers and neurogenic arthropathy (Charcot joints) causing severe morbidity and high health-care costs. Objective: To discuss the different patterns of sensory alterations in diabetic neuropathies and their anatomical basis. Study design: Literature review. Methods: Review of the literature discussing different patterns of sensory impairment in diabetic neuropathies. Results: The different varieties of diabetic neuropathies include typical sensorimotor polyneuropathy (lower extremity predominant, length-dependent, symmetric, sensorimotor polyneuropathy presumably related to chronic hyperglycemic exposure, and related metabolic events), entrapment mononeuropathies, radiculoplexus neuropathies related to immune inflammatory ischemic events, cranial neuropathies, and treatment-related neuropathies (e.g. insulin neuritis). None of these patterns are unique for diabetes, and they can occur in nondiabetics. Sensory alterations are different among these prototypic varieties and are vital in diagnosis, following course, treatment options, and follow-up of treatment effects. Conclusions: Diabetic neuropathies can involve any segment of peripheral nerves from nerve roots to the nerve endings giving different patterns of abnormal sensation. It is the involvement of small fibers that causes positive sensory symptoms like pain early during the course of disease, bringing subjects to physician’s care. Clinical Relevance This article emphasizes on the fact that diabetic neuropathies are not a single entity. They are rather different varieties of conditions with more or less separate pathophysiological mechanisms and anatomical localization. Clinicians should keep this in mind when assessing patients with diabetes on the first visit or follow-up.

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Ward, J. D. "Diabetic Neuropathies". Drugs 32, n.º 3 (setembro de 1986): 279–89. http://dx.doi.org/10.2165/00003495-198632030-00004.

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Vinik, A. I., M. T. Holland, J. M. L. Beau, F. J. Liuzzi, K. B. Stansberry e L. B. Colen. "Diabetic Neuropathies". Diabetes Care 15, n.º 12 (1 de dezembro de 1992): 1926–75. http://dx.doi.org/10.2337/diacare.15.12.1926.

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Russell, James W., e Lindsay A. Zilliox. "Diabetic Neuropathies". CONTINUUM: Lifelong Learning in Neurology 20 (outubro de 2014): 1226–40. http://dx.doi.org/10.1212/01.con.0000455884.29545.d2.

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Perkins, Bruce, Vera Bril e Aaron Izenberg. "Diabetic Neuropathies". Seminars in Neurology 35, n.º 04 (6 de outubro de 2015): 424–30. http://dx.doi.org/10.1055/s-0035-1558972.

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Mais fontes

Teses / dissertações sobre o assunto "Diabetic neuropathies"

Steel, Kay Elizabeth. "Novel mechanisms underlying diabetic neuropathy". Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158829.

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Investigation into the molecular basis of diabetes-induced erectile dysfunction was carried out on corpus cavernosum tissue from control and streptozotocin (STZ)-induced diabetic rats. Increased expression of endothelial nitric oxide synthase (eNOS) and increased nitrosative stress was found in the diabetic penile tissue. Diabetic neuropathy is associated with a failure in axonal regeneration. In vitro axon growth, guidance and regeneration model systems were used to study both the intrinsic nature of diabetic DRG neurones to grow and respond to guidance cues, but also to study the supportive properties of the diabetic nerve environment for axon regeneration. Cyclic Adenosine-3’5-Monophosphate (cAMP) signalling is compromised in diabetic DRG neurones. Increasing cAMP in diabetic neurones reduced the deficit in neurite growth and reversed the aberrant response of diabetic neuronal growth cones to the cAMP-dependent trophic factor, nerve growth factor (NGF). Diabetic neurones display reduced expression of Exchange protein activated by cAMP (Epac), a downstream effector of cAMP. Specifically activating Epac also rescued the abnormal turning responses of diabetic DRG neurones. Impaired axonal regeneration in diabetes has been, in part, attributed to delayed Wallerian degeneration. Using the cryoculture bioassay, it was shown that during regeneration the peripheral nerve environment, of both control and diabetic rats are equally supportive for axon growth. In summary, this is the first study to imply that specific signalling mechanisms, involving the cAMP-Epac pathway, may be compromised in neurones from diabetic rats, which contribute towards reduced neurite growth and abnormal responses to axon guidance cues.

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Lindström, Per. "Diabetic neuropathy : clinical and experimental studies /". Stockholm, 1997. http://diss.kib.ki.se/1997/19971003lind.

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Fortaleza, Ana Claudia de Souza [UNESP]. "Controle postural, equilíbrio funcional e estabilidade do ato de locomoção na neuropatia diabética periférica". Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/87316.

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Made available in DSpace on 2014-06-11T19:22:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-16Bitstream added on 2014-06-13T20:49:20Z : No. of bitstreams: 1 fortaleza_acs_me_prud.pdf: 477345 bytes, checksum: f49debf4b9a2f0a76c98e9512ad369eb (MD5)
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O objetivo do estudo foi verificar a estabilidade do ato de locomoção em diabéticos com neuropatia periférica, em três situações: marcha habitual com os olhos abertos; marcha com os olhos fechados e marcha com olhos abertos e diminuição da base de sustentação. Participaram do estudo 41 indivíduos, sendo 18 do grupo neuropata e 23 do grupo controle (GC). A avaliação da estabilidade foi realizada por meio de um baropodômetro associado ao software Footwalk Pro. Os dados obtidos foram: velocidade da marcha e porcentagens de tempo de duplo apoio e de apoio simples. Foram encontradas diferenças significantes nas três situações entre os grupos para a velocidade e tempo de apoio simples, com diminuição para o grupo neuropata (p<0,05), e tempo de duplo apoio, com aumento para esse grupo (p<0,05) em todas as condições. Para os dados de velocidade, tempo de duplo apoio e tempo de apoio simples, a condição de olho aberto foi diferente da condição de olho fechado (p=0,001) e da condição com diminuição da base de sustentação (p=0,001). Foi possível observar que nas três situações avaliadas, o grupo neuropata apresentou déficit na estabilidade do ato de locomoção e tal desempenho foi ainda mais comprometido nas duas situações que exigiam mais do controle postural. Tais modificações da marcha, decorrentes da complexidade imposta pelas diferentes condições, sugerem a inserção destas na avaliação e no tratamento dessa população
The aim of this study was to verify the stability of the act of locomotion in diabetics with peripheral neuropathy in three situations: habitual gait with eyes opened, gait with eyes closed, and gait with eyes opened and reduced base of support. The study included 41 subjects: 18 of the neuropathic group and 23 in the control group. The stability was evaluated by baropodometry platform associated with the software Footwalk Pro. Data were obtained: gait speed and percentual of double stance time and single stance time. Significant differences were found in the three cases between the groups in the data of gait speed and single stance time, with a larger reduction for neuropathic group (p<0,05) and increased in double stance time in the neuropathic group (p<0,05) in all conditions. For data of gait speed measure, double stance time and single stance time, the condition eyes opened was different from eyes closed (p=0,001) and from the condition with reduced base of support (p=0,001). It was observed that in the three situations evaluated, the neuropathic group showed stability locomotion deficit and the performance was more injured in both situations that required more postural control. Such gait modifications, due to the complexity imposed by different conditions, suggest the inclusion of these in the evaluation and treatment of this population

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Walters, David Paul. "The prevalence of diabetic foot disease". Thesis, University of London, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320402.

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During a surveillance programme all the known diabetics (1150) were identified from a general population of 97,034 representing all patients registered with 10 general practices. A control group of 751 non-diabetic subjects were also drawn from the same general population. A single observer reviewed 1077 (93.6%) of the diabetics and 480 (69%) of the controls. Peripheral vascular disease was detected using doppler ankle/brachial pressure index in 20.6% (95% CI 18.2-23.0) of diabetics and 9.6% (95% CI 7.0-11.2) of controls. There was no significant difference between the prevalence in non-insulin dependent and insulin dependent diabetics after adjusting for age. The prevalence in either type of diabetes was however significantly greater than in controls. Multiple logistic regression analysis revealed that age, cerebrovascular disease, coronary artery disease, mean systolic blood pressure, blood glucose, proteinuria and serum cholesterol were significantly and independently associated with the presence of peripheral vascular disease in diabetics. Body mass index was inversely associated. For controls only age and smoking were found to be significant variables. Neuropathy determined by clinical evaluation and sensory vibration thresholds was found in 16.8% (95% CI 14.6-19.0) of diabetics and 2.9% (95% CI 1.4-4.3) of controls (p

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Camargo, Marcela Regina de [UNESP]. "Parâmetros espaço temporais da marcha e inter-relação com equilíbrio e força muscular isométrica de tornozelos em diabéticos com neuropatia periférica". Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/87311.

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O Diabetes mellitus é uma enfermidade crônica que leva a alterações sensitivas e motoras. Tais alterações comprometem o equilíbrio e a deambulação predispondo seus portadores à ocorrência de quedas. Esta revisão teve por objetivo levantar, na literatura recente, estudos que visassem avaliar parâmetros da marcha e aspectos envolvidos com a deambulação. Para isso, foi realizada uma busca nas bases de dados MEDLINE, SciELO, LILACS e PEDro, cruzando as palavras-chaves: Neuropatias Diabéticas x Marcha; Diabetes Mellitus x Marcha e Pé Diabético x Marcha. Após passarem pelos critérios de seleção, foram obtidos 15 artigos, os quais foram sintetizados e discutidos, sendo, portanto, incluídos nesta revisão. Ficou claro que a neuropatia diabética leva a déficits na amplitude do passo, velocidade e cadência da marcha em superfícies planas, sem mudanças bruscas de direção ou paradas, e, déficits de equilíbrio e coordenação em aclives, declives e terrenos irregulares. Acarreta, também, aumento dos índices de pressão plantar e, devido à alteração de ativação do tríceps sural, dificuldade na fase de apoio terminal e prébalanço. Assim, o próximo contato inicial ocorrerá de maneira inadequada, com o antepé e sem absorção de choques.
Diabetes mellitus is a chronic disease that leads to sensory-motor changes. These changes affect balance and walking predisposing their patients to falls occurrence. This review aimed to investigate, in recent literature, assessing gait parameters and walking studies involved aspects. For this, a search was conducted in databases MEDLINE, SciELO, LILACS and PEDro, crossing the keywords: Diabetic neuropathies x Gait; Diabetes Mellitus x Gait and Diabetic Foot x Gait. After passing by selection criteria, it was remainder 15 articles, which were synthesized, discussed and is therefore included in this review. It was clear that diabetic neuropathy leads to deficits in the step amplitude, gait velocity and gait cadence on flat surfaces, without sudden changes of direction or stops, and balance and coordination deficits in slopes and uneven terrain. Diabetic neuropathies, provide, also increase plantar pressure rates due to the triceps sural activation change, difficulty in the terminal phase of support and pre-assessment. Thus, the next initial contact occurs in an inadequate way, with the forefoot and without absorption of shocks.

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Camargo, Marcela Regina de. "Parâmetros espaço temporais da marcha e inter-relação com equilíbrio e força muscular isométrica de tornozelos em diabéticos com neuropatia periférica /". Presidente Prudente : [s.n.], 2009. http://hdl.handle.net/11449/87311.

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Orientador: Cristina Elena Prado Teles Fregonesi
Banca: Claudia Regina Sgobbi de Faria
Banca: José Angelo Barela
Resumo: O Diabetes mellitus é uma enfermidade crônica que leva a alterações sensitivas e motoras. Tais alterações comprometem o equilíbrio e a deambulação predispondo seus portadores à ocorrência de quedas. Esta revisão teve por objetivo levantar, na literatura recente, estudos que visassem avaliar parâmetros da marcha e aspectos envolvidos com a deambulação. Para isso, foi realizada uma busca nas bases de dados MEDLINE, SciELO, LILACS e PEDro, cruzando as palavras-chaves: Neuropatias Diabéticas x Marcha; Diabetes Mellitus x Marcha e Pé Diabético x Marcha. Após passarem pelos critérios de seleção, foram obtidos 15 artigos, os quais foram sintetizados e discutidos, sendo, portanto, incluídos nesta revisão. Ficou claro que a neuropatia diabética leva a déficits na amplitude do passo, velocidade e cadência da marcha em superfícies planas, sem mudanças bruscas de direção ou paradas, e, déficits de equilíbrio e coordenação em aclives, declives e terrenos irregulares. Acarreta, também, aumento dos índices de pressão plantar e, devido à alteração de ativação do tríceps sural, dificuldade na fase de apoio terminal e prébalanço. Assim, o próximo contato inicial ocorrerá de maneira inadequada, com o antepé e sem absorção de choques.
Abstract: Diabetes mellitus is a chronic disease that leads to sensory-motor changes. These changes affect balance and walking predisposing their patients to falls occurrence. This review aimed to investigate, in recent literature, assessing gait parameters and walking studies involved aspects. For this, a search was conducted in databases MEDLINE, SciELO, LILACS and PEDro, crossing the keywords: Diabetic neuropathies x Gait; Diabetes Mellitus x Gait and Diabetic Foot x Gait. After passing by selection criteria, it was remainder 15 articles, which were synthesized, discussed and is therefore included in this review. It was clear that diabetic neuropathy leads to deficits in the step amplitude, gait velocity and gait cadence on flat surfaces, without sudden changes of direction or stops, and balance and coordination deficits in slopes and uneven terrain. Diabetic neuropathies, provide, also increase plantar pressure rates due to the triceps sural activation change, difficulty in the terminal phase of support and pre-assessment. Thus, the next initial contact occurs in an inadequate way, with the forefoot and without absorption of shocks.
Mestre

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Tirrell, Lee Sean. "The role of RhoA GTPase activating protein DLC2 in painful diabetic neuropathy". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/195956.

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Neuropathy is a major complication that affects nearly half of all patients with diabetes, greatly decreasing their quality of life. Patients experience a wide range of symptoms including pain, numbness, weakness and other morbidities. While its pathogenesis has been the focus of extensive research, there are still few effective treatment options available for this disease. The discovery of novel molecular targets underlying this diabetic neuropathy may lead to the development of new, more effective therapeutics. DLC2, a Rho GTPase-activating protein with specific activity for RhoA, was shown to be involved in pain signaling. Mice deficient for this protein (DLC2-/-) have increased RhoA activity in their peripheral nerves, and have heightened pain responses compared to wild type (DLC2+/+) in acute pain tests, displaying increased sensitivity to noxious thermal and inflammatory stimuli. DLC2-/- mice also show elevated blood glucose levels, lower body weight and increased sensitivity to blood glucose compared to wild type. Because of the hyperalgesia to acute pain displayed by DLC2-/- mice compared to wild type, and since the RhoA pathway is known to be involved in the pathogeneses and maintenance of diabetes and its complications, these mice were used to investigate more clinically relevant, chronic pain in a model of diabetic neuropathy. Streptozotocin (STZ), given in multiple low doses over five days (MLDS treatment), was used to induce diabetes in DLC2+/+ and DLC2-/- mice, and their pain responses were tested 8 weeks later. Diabetic DLC2-/- mice (DLC2-/--STZ) were hyperalgesic to thermal stimuli from the hot plate test compared to diabetic DLC2 wild type mice (DLC2+/+-STZ) and vehicle-treated controls of both genotypes (DLC2-/--Veh and DLC2+/+-Veh. Similar responses were seen from the von Frey filament test, where the DLC2-/--STZ group exhibited mechanical allodynia compared to the DLC2+/+-STZ group and both control groups. Dorsal root ganglia (DRG) were dissected from these four groups of mice for qPCR screening and protein analysis. DLC2-/--STZ mice showed significantly higher gene expression of the voltage-gated sodium channel Nav 1.9 compared to DLC2+/+-STZ mice, while there was a strong trend of increased levels in the DLC2-/--STZ group compared to both non-diabetic groups. Western blot analysis of the DRG from these mice shows increased levels of COX-2 expression of DLC2-/--STZ mice compared to DLC2+/+-Veh, and elevated levels of phosphorylated ERK (pERK) in DLC2-/--Veh and both diabetic groups compared to DLC2+/+-Veh. Overall, diabetic DLC2-/- mice have more severe painful diabetic neuropathy, with thermal hyperalgesia and mechanical allodynia. Increased RhoA activity and pERK, which are known to be involved in regulation, transcription and trafficking of sodium channels, may lead to increased Nav1.9 mRNA levels and activation. Localized mainly to nociceptors of the DRG, Nav1.9 is known to play a role in sensitizing neurons through lowering the threshold for action potentials, possibly leading to the observed heightened pain response. Additionally, elevated COX-2 levels in DLC2-/--STZ mice may lead to further deficits through activation of inflammatory responses. Future studies will further investigate how these mechanisms are involved in the altered pain response from diabetes.
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Anatomy
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Kulik, Destini. "Reflexology and massage in the treatment of Type II diabetic neuropathy". Scholarly Commons, 2002. https://scholarlycommons.pacific.edu/uop_etds/571.

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Fortaleza, Ana Claudia de Souza. "Controle postural, equilíbrio funcional e estabilidade do ato de locomoção na neuropatia diabética periférica /". Presidente Prudente : [s.n.], 2011. http://hdl.handle.net/11449/87316.

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Orientador: Cristina Elena Prado Teles Fregonesi
Banca: Dalva Minonroze Albuquerque Ferreira
Banca: Marli Aparecida Defani
Resumo: O objetivo do estudo foi verificar a estabilidade do ato de locomoção em diabéticos com neuropatia periférica, em três situações: marcha habitual com os olhos abertos; marcha com os olhos fechados e marcha com olhos abertos e diminuição da base de sustentação. Participaram do estudo 41 indivíduos, sendo 18 do grupo neuropata e 23 do grupo controle (GC). A avaliação da estabilidade foi realizada por meio de um baropodômetro associado ao software Footwalk Pro. Os dados obtidos foram: velocidade da marcha e porcentagens de tempo de duplo apoio e de apoio simples. Foram encontradas diferenças significantes nas três situações entre os grupos para a velocidade e tempo de apoio simples, com diminuição para o grupo neuropata (p<0,05), e tempo de duplo apoio, com aumento para esse grupo (p<0,05) em todas as condições. Para os dados de velocidade, tempo de duplo apoio e tempo de apoio simples, a condição de olho aberto foi diferente da condição de olho fechado (p=0,001) e da condição com diminuição da base de sustentação (p=0,001). Foi possível observar que nas três situações avaliadas, o grupo neuropata apresentou déficit na estabilidade do ato de locomoção e tal desempenho foi ainda mais comprometido nas duas situações que exigiam mais do controle postural. Tais modificações da marcha, decorrentes da complexidade imposta pelas diferentes condições, sugerem a inserção destas na avaliação e no tratamento dessa população
Abstract: The aim of this study was to verify the stability of the act of locomotion in diabetics with peripheral neuropathy in three situations: habitual gait with eyes opened, gait with eyes closed, and gait with eyes opened and reduced base of support. The study included 41 subjects: 18 of the neuropathic group and 23 in the control group. The stability was evaluated by baropodometry platform associated with the software Footwalk Pro. Data were obtained: gait speed and percentual of double stance time and single stance time. Significant differences were found in the three cases between the groups in the data of gait speed and single stance time, with a larger reduction for neuropathic group (p<0,05) and increased in double stance time in the neuropathic group (p<0,05) in all conditions. For data of gait speed measure, double stance time and single stance time, the condition eyes opened was different from eyes closed (p=0,001) and from the condition with reduced base of support (p=0,001). It was observed that in the three situations evaluated, the neuropathic group showed stability locomotion deficit and the performance was more injured in both situations that required more postural control. Such gait modifications, due to the complexity imposed by different conditions, suggest the inclusion of these in the evaluation and treatment of this population
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傅子穎 e Tsi-wing Fu. "The expression and regulation of genes that may contribute to the etiology of diabetic neuropathy in mouse". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31215245.

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Livros sobre o assunto "Diabetic neuropathies"

D, Ward J., e Gotō Yoshio 1925-, eds. Diabetic neuropathy. Chichester: Wiley, 1990.

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International, Symposium on Diabetic Neuropathy (3rd 1994 Kanagawa-ken Japan). Diabetic neuropathy: New concepts and insights : proceedings of the 3rd International Symposium on Diabetic Neuropathy, Kanagawa, 3-5 November 1994. Amsterdam: Elsevier, 1995.

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Aristidis, Veves, ed. Clinical management of diabetic neuropathy. Totowa, N.J: Humana Press, 1998.

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Pfeifer, Michael A. Diabetic neuropathy. Kalamazoo, Mich: Upjohn, 1985.

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Veves, Aristidis. Diabetic neuropathy: Clinical management. 2^a ed. Totowa, N.J: Humana Press, 2007.

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Veves, Aristidis. Diabetic neuropathy: Clinical management. 2^a ed. Totowa, N.J: Humana Press, 2007.

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Veves, Aristidis. Diabetic neuropathy: Clinical management. 2^a ed. Totowa, N.J: Humana Press, 2007.

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Veves, Aristidis. Diabetic neuropathy: Clinical management. 2^a ed. Totowa, N.J: Humana Press, 2007.

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R, Tomlinson David, ed. Neurobiology of diabetic neuropathy. Amsterdam: Academic Press, 2002.

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International Diabetes Conference on Vascular and Neurologic Complications of Diabetes Mellitus. (2nd 1985 Florence, Italy). Vascular and neurologic complications of diabetes mellitus. Editado por Belfiore Francesco, Molinatti G. M e Williamson J. R. Basel ; New York: Karger, 1987.

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Capítulos de livros sobre o assunto "Diabetic neuropathies"

Vinik, Aaron I. "Diabetic Neuropathies". In Controversies in Treating Diabetes, 109–34. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-572-5_7.

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Vinik, Aaron I. "Diabetic Neuropathies". In Controversies in Treating Diabetes, 135–56. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-572-5_8.

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Vinik, Aaron I. "Diabetic Neuropathies". In Atlas of Diabetes, 295–312. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1028-7_14.

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Zochodne, Douglas W. "Diabetic Neuropathies". In Neuromuscular Disorders, 170–76. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781119973331.ch22.

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Bird, Shawn J., e Mark J. Brown. "Diabetic Neuropathies". In Neuromuscular Disorders in Clinical Practice, 647–73. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6567-6_31.

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Schmidt, Robert E. "Diabetic neuropathies". In Peripheral nerve disorders, 224–32. Chichester, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118618424.ch28.

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Pop-Busui, Rodica. "Diabetic Neuropathies". In 2016 Meet-The-Professor: Endocrine Case Management, 101–4. 2055 L Street, NW, Suite 600, Washington, DC 20036: The Endocrine Society, 2016. http://dx.doi.org/10.1210/mtp5.9781943550043.ch20.

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Cheng, Hsinlin Thomas, e Anne Louise Oaklander. "Diabetic Neuropathies". In Encyclopedia of Pain, 954–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-28753-4_1086.

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Montenegro, Ana Carla, Luiz Griz e Francisco Bandeira. "The Diabetic Neuropathies". In Endocrinology and Diabetes, 445–54. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8684-8_35.

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Feher, Gergely. "Peripheral Diabetic Neuropathies". In The Diabetes Textbook, 809–23. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11815-0_52.

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Trabalhos de conferências sobre o assunto "Diabetic neuropathies"

Losada, Ana Laura Pereira, e Guilherme Dalpiva. "A EFICACIA DA CINESIOTERAPIA E PROPRIOCEPÇÃO EM PACIENTES COM POLINEUROPATIA DIABÉTICA: UMA REVISÃO SISTEMÁTICA". In II Congresso Brasileiro de Saúde On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1525.

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Introdução: A diabetes mellitus (DM) é uma doença crônica no qual o corpo não produz insulina ou não consegue empregar de forma adequada a insulina que produz. É uma das enfermidades mais diagnosticadas nos últimos anos no mundo todo e afeta uma grande quantidade de indivíduos. a Polineuropatia diabética é uma das complicações mais comuns ocasionadas pela DM gerando diversos sintomas como o déficit de sensibilidade periférica dos MMII, que consequentemente aumenta o risco de quedas entre os portadores da doença. Objetivo: Analisar tratamentos de cinesioterapia e propriocepção, e sua eficácia com déficit sensórios motores causados pela polineuropatia diabética. Materiais e Métodos: Por meio de uma revisão sistemática, através de buscas em bases de dados, foram admitidos apenas ensaios clínicos publicados entre os anos de 2010 e 2020. A busca envolveu as bases de dados SciELO, BVS, PubMed, PEDro e Google acadêmico, utilizando os descritores “Physical Therapy Specialty”; “Diabetic Neuropathies”; “Exercise Therapy”; “Proprioception”; “Adult”; “Aged”. A triagem dos artigos, foi realizada por dois pesquisadores, e foram incluídos ensaios clínicos, teses e doutorados que abordassem trabalho proprioceptivo e de equilíbrio em pacientes neuropatas diabéticos. Resultados: Na análise inicial, a busca resultou em 69 registros potencialmente relevantes, porém 57 foram excluídos e apenas 12 contemplaram os critérios de seleção e destes todos atingiram a pontuação estabelecida na escala PEDro. Conclusão: Por meio desta análise metodológica, foi possível concluir que um trabalho postural, de equilíbrio estático e dinâmico com propriocepção é de fato efetivo, trazendo melhora das disfunções dos portadores de Polineuropatia diabética. Porém, alguns protocolos ainda necessitam de estudos e maior tempo de aplicação para concluir sua eficácia.

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Ford, I., P. G. Newrick, R. Malik, F. E. Preston, J. D. Ward e M. Greaves. "HAEMOSTATIC PARAMETERS, ENDONEURIAL OXYGEN TENSION AND SURAL NERVE HISTOLOGY IN DIABETES MELLITUS". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643107.

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We have examined coagulation parameters in 15 neuropathic (Group A) and 10 complication-free diabetic patients (Group B). Venesection and sample testing were performed under standard conditions. Group A underwent sural nerve biopsy and 14 also had measurements of endoneurial oxygen tension. Factor VIII related antigen was higher in Group A (l-617u/ml ± 0.67) compared to Group B (0.944u/ml ± 0.26); (mean ± SD; p<.0.05) perhaps suggesting endothelial cell damage, although this did not correlate with capillary basement membrane thickness or endothelial cell number nor with endoneurial oxygen levels. Platelets from Group A were more sensitive to arachidonate than those of Group B, showing aggregation thresholds in platelet rich plasma of 0.36 ± 0.17mM and 0.57 ± 0.9mM respectively compared with 0.65 ± 0.37mM in non-diabetic controls.Platelets from Group A subjects also produced more thromboxane B2 in response to arachidonate than Group B or normal controls (37.95 ± 27.5; 25.5 ± 13.0; 16.55 ± 15-5pmol/107 platelets). Blood fibrinolytic capacity measured by euglobulin clot lysis time, was diminished in NIDDs (post-occlusion ECLT 165.7 mins ± 116.0), compared to IDDs (55.5 ± 34.5) (p<0.05) due at least in part to excess of tissue plasminogen-activator inhibitor, although we found no significant difference in ECLT between Group A and Group B. Interaction between haemostatic and microvascular abnormalities in diabetes may contribute to the pathogenesis of diabetic neuropathy.

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Stella, Isabela de Almeida, Herval Ribeiro Soares Neto, Vanessa de Freiras Moreira, Arthur da Veiga Kalil Coelho, Kássia Braga Canzian, Marcella Canato Toloi, Amanda Freitas Alves e Sephora Sabrina Candido. "Response of neuropathic pain to intravenous immunoglobulin in diabetic amyotrophy: a case report". In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.686.

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Introduction: A 58-year-old male patient, diagnosed with diabetes mellitus (DM) five years ago, started with neuropathic pain in the lumbar region radiating to the right thigh, and later to the left thigh, progressing to difficulty walking and significant weight loss over six months. On examination, patient with grade IV proximal paraparesis, slightly asymmetrical, associated with muscle atrophy and abolished reflexes. Regarding the upper limbs, the examination was normal. During the investigation, electroneuromyography (ENMG) showed sensory and motor involvement in the lower limbs, with a mixed pattern, associated with cerebrospinal fluid with hyperproteinorrachia. The rest of the exams did not show alterations, raising the hypothesis of diabetic amyotrophy (DA). Discussion: DA affects less than 1% of all diabetic patients. Its typical clinical presentation is the presence of acute pain in the proximal region of the lower limbs, initially unilateral, evolving with paresis and muscle atrophy, as well as involvement of the contralateral limb in more advanced cases. The diagnosis is based mainly on clinical suspicion. ENMG demonstrates a pattern more related to axonal degeneration than demyelination, generally sparing upper limbs. Currently, there is no evidence to support or contraindicate any immunotherapy in the treatment of DA. In this case, IVIg was performed with excellent response in pain control. Conclusion: Despite being a less common complication related to DM, DA becomes important in a scenario of increased incidence of metabolic diseases in the Brazilian population. It is important to know its presentation to aid in the diagnosis of a disease thais is rate but with an excellent response to IVIg infusion.

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Prior, Fred, Paul K. Commean, Tao Ju, Mary Hastings, Charles Hildebolt e David R. Sinacore. "Developing a biomarker for neuropathic arthropathy in diabetic patients". In 2007 IEEE/NIH Life Science Systems and Applications Workshop. IEEE, 2007. http://dx.doi.org/10.1109/lssa.2007.4400873.

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Abu-Hasaballah, Khamis S., Michael D. Nowak e Paul D. Cooper. "Enhanced Solid Ankle-Foot Orthosis Design: Real-Time Contact Pressures Evaluation and Finite Element Analysis". In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0340.

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Abstract Adult neuropathic diabetic patients with acquired foot deformities such as flat foot and Charcot feet often develop plantar foot ulceration, leading to extended hospital procedures. These ulcerations are attributed to elevated plantar contact pressures (Ctercteko, 1981). A recent preventative means is to fit the patient with a custom made ankle-foot-orthosis (AFO) designed to reduce these pressures. Although effective, AFOs have poor patient compliance due to their high weight.

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Kender, Z., JB Groener, J. Jende, F. Kurz, J. Rusdian Masjkur, PP Nawroth, M. Bendszus e S. Kopf. "Diabetische sensomotorische Neuropathie der oberen Extremität: klinische, neurophysiologische und MR-Neurographische Aspekte". In Diabetes Kongress 2019 – 54. Jahrestagung der DDG. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1688182.

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Kender, Z., JB Groener, JR Masjkur, S. Bischoff, A. Pflästerer, A. Hagedorn-Dambuk, PP Nawroth e S. Kopf. "Diabetische sensomotorische Neuropathie der Hände bei Patienten mit Diabetes mellitus Typ 2". In Diabetes Kongress 2018 – 53. Jahrestagung der DDG. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1641963.

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Nandikolla, Vidya K., Marco P. Schoen e Ajay Mahajan. "Active Foot Pressure Control for Diabetic Neuropathy During Walking". In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-79783.

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Diabetic Mellitus is a disease caused either due to insufficient insulin produced by the pancreas or the body cells are unable to use the existing insulin. One of the main complications associated with diabetics is neuropathy, which is caused due to complete or partial loss of sensation in the feet and legs that lead to problems like inadequate delivery of nutrients and oxygen to the foot, which will cause healing impairment. In diabetic neuropathic subject, the hardness of foot sole soft tissue gives rise to plantar ulcer development. In this work, a biomechanical model is used to study the plantar distribution of forces in the foot. The dynamic foot pressure distribution during walking is used to carry out a stress analysis. This includes the motion of heel strike, mid-stance, and push off section of the feet during walking. A control strategy is proposed to mitigate the high stress concentration occurring during the walking phase. The control strategy includes a synergy of an adaptive neuro-fuzzy inference controller and for comparison an optimal controller. The actuation is simulated through an external shoe insert. The three-dimensional multi-segment biomechanical model is used in conjunction with experimental data gathered from various literatures for simulation purposes of the proposed control strategy. The proposed intelligent controller focuses on stresses generated by the foot pressure distribution during walking and compares these with stress levels of healthy subjects. The insert changes its shape accordingly to redistribute the pressure levels at various regions so to achieve a pressure distribution equivalent to a healthy subject. It is assumed that the insert can actuate and measure the pressure distribution simultaneously. This could be achieved using smart materials for the shoe insert. The simulation results show the effectiveness of the proposed algorithms and approach.

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Madavi, Monali V., e Shubhangi D. Giripunje. "Design and Implementation of Wearable Device for Neuropathic Diabetic Foot Patients". In 2015 7th International Conference on Emerging Trends in Engineering & Technology (ICETET). IEEE, 2015. http://dx.doi.org/10.1109/icetet.2015.14.

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Gomes, Aline A., Arturo Forner-Cordero, Marko Ackermann e Isabel C. N. Sacco. "Dynamic simulation of hip strategy of diabetic neuropathic individuals during gait". In 2014 5th IEEE RAS & EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob). IEEE, 2014. http://dx.doi.org/10.1109/biorob.2014.6913778.

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Relatórios de organizações sobre o assunto "Diabetic neuropathies"

Xing, Ying, Hongping Liu, Yifei Wang e Tiancai Wen. Effects of acupuncture on pain in diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, setembro de 2022. http://dx.doi.org/10.37766/inplasy2022.9.0019.

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Review question / Objective: The purpose of this review is to determine the efficacy and safety of acupuncture on diabetic peripheral neuropathy (DPN) pain compared with analgesics or sham acupuncture.Randomized controlled trials are the only types of studies included in this review. Condition being studied: Diabetic peripheral neuropathy (DPN) is a common complication of type 1 and 2 diabetes. It is also the main cause of lower limb amputation and disability in patients with diabetes. Epidemiological evidence shows that up to 50% of patients with diabetes developed neuropathy during their long-term course of disease. The cause of DPN is not completely clear, but older age, longer diabetic duration and worse postprandial glucose control has been proved to be closely related to DPN. Distal symmetric polyneuropathy is the most typical manifestation of DPN, and about 10% to 30% of the affected patients may experience symptoms of neuropathic pain. Pain can be described as burning pain, electrical or stabbing sensations, parasthesiae, hyperasthesiae, and deep aching pain of the feet and lower limbs at night. This irreversible and unbearable pain greatly affects patients' sleep and quality of life.

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Lekhanya, Portia Keabetswe, e Kabelo Mokgalaboni. Exploring the effectiveness of vitamin B12 complex and alpha-lipoic acid as a treatment for diabetic neuropathy. Protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, maio de 2022. http://dx.doi.org/10.37766/inplasy2022.5.0167.

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Review question / Objective: Does Alpha-Lipoic acid increase the uptake of glucose for better glycaemic control? Does vitamin B12 and Alpha-Lipoic acid improve inflammation? The aim of the study is to explore the effectiveness of Vitamin B12 and Alpha-Lipoic Acid as a possible treatment for diabetic neuropathy with major emphasis on markers of inflammation and glucose metabolism. Condition being studied: Diabetic Neuropathy (DN) is a heterogeneous type of nerve damage associated with diabetes mellitus, the condition most often damages nerves in the legs and feet. It presents both clinically and sub-clinically affecting the peripheral nervous system as a result of an increase in glucose concentration which interferes with nerve signalling. After the discovery of insulin as a treatment for Diabetes Mellitus (DM), the prevalence of DN has since increased significantly due to DM patients having a longer life expectancy. It has been estimated that atleast 50% of DM patients will develop DN in their life, with approximately 20% of these patients experiencing neuropathic pain. Nerves are susceptible to changes in glucose concentrations and insulin makes it impossible for neurons to continue regulating glucose uptake.

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Wang, Liqin, Zhaohong Gao, Xiangru Niu, Meiqi Yuan, Yan Li, Fei Wang, Chuang Guo e Zhen Ren. Acupuncture for diabetic neuropathic pain: protocol for a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, setembro de 2020. http://dx.doi.org/10.37766/inplasy2020.9.0043.

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Zheng, Ruo-xiang, Jia-wei Xu, Bi-yao Jiang, Wei Tang, Chun-li Lu, Xiao-yang Hu e Jian-ping Liu. Mind-body therapies in traditional Chinese medicine for neuropathic pain: a systematic review of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, abril de 2022. http://dx.doi.org/10.37766/inplasy2022.4.0016.

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Review question / Objective: The purpose of this review is to comprehensively evaluate the effectiveness and safety on mind-body therapies of traditional Chinese medicine for neuropathic pain. Condition being studied: According to the definition by the International Association for the Study of Pain (IASP), neuropathic pain is a kind of pain caused by lesions or diseases affecting the somatosensory nervous system. It has brought considerable negative impacts on patients and society. Neuropathic pain is a prevalent disease and can be induced by a variety of clinical conditions such as spinal cord injury (prevalence rate: 53%), induced peripheral neuropathic pain (prevalence rate: 38%), diabetic peripheral neuropathic pain (prevalence rate: 10%-26%), chemotherapy postherpetic neuralgia (3.9-42.0/10,000 people per year), prosopalgia (3-5/10,000 people per year), and so on. However, current recommended medicines for neuropathic pain management could cause dependence and adverse events. Thus, alternatives would be helpful for both patients and clinicians. Mind-body therapy in traditional Chinese medicine (TCM) has a long history in clinical practice for relieving pain and their effectiveness has not been systematically reviewed.The purpose of this review is to comprehensively evaluate the effectiveness and safety on mind-body therapies of traditional Chinese medicine for neuropathic pain.

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Chigbundu, Glory, Sam Ibeneme e Chidimma Omeje. Effects of physical exercises on glycosylated hemoglobin, inflammation and neuropathic index in diabetic conditions. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, julho de 2023. http://dx.doi.org/10.37766/inplasy2023.7.0030.

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