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Teses / dissertações sobre o tema "Dosage reduction"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 9 de fevereiro de 2022

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1

Nlooto, Manimbulu. "Effect of stavudine dosage reduction on the incidence of symptomatic hyperlactataemia/lactic acidosis in adults female HIV/AIDS infected patients treated at Dr George Mukhari Hospital." Thesis, University of Limpopo (Medunsa Campus), 2010. http://hdl.handle.net/10386/216.

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Theses (Msc.(Med.)(Pharmacy))--University of Limpopo, 2010.<br>With the availability of Highly Active Antiretroviral Therapy (HAART), one of the limitations of treatment safety is the occurrence of adverse events associated with antiretroviral agents. The aim of this study was to establish whether stavudine dosage reduction prevents toxicity from developing and minimizes the incidence of symptomatic hyperlactataemia/lactic acidosis (LA) in adults female HIV/AIDS infected patients. This retrospective study covered adult patients treated at the adult ARV clinic, Dr George Mukhari Hospital

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2

Hartmangruber, David Patrick. "Using MAVRIC sequence to determine dose rate to accessible areas of the IRIS nuclear power plant." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37123.

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The objective of this thesis is to determine and analyze the dose rate to personnel throughout the proposed IRIS nuclear power plant. To accomplish this objective, complex models of the IRIS plant have been devised, advanced transport theory methods employed, and computationally intense simulations performed. IRIS is an advanced integral, light water reactor with a 335 MWe expected power output (1000 MWth). Due to its integral design, the IRIS pressure vessel has a large downcomer region. The large downcomer and the neutron reflector provide a great deal of additional shielding. This inc

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3

Gervaise, Alban. "Optimisation et réduction de la dose d’irradiation au scanner : aspects techniques et impact en pratique clinique courante." Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0136/document.

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Depuis son introduction dans les années 1970, le scanner est devenu une technique d’imagerie médicale incontournable grâce à son excellente performance pour le diagnostic de nombreuses pathologies. Toutefois, le scanner est un examen d’imagerie irradiant. Compte-tenu des risques potentiels de cancer radio-induit liés aux faibles doses de rayons X, la réduction de la dose d’irradiation au scanner est primordiale. Dans ce travail, nous avons étudié plusieurs facteurs techniques et comportementaux qui permettent d’optimiser et de réduire la dose d’irradiation au scanner, tout en préservant une ex

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4

Podd, Frank J. W. "Medical X-ray dose reduction including adaptive image processing." Thesis, University of Surrey, 1997. http://epubs.surrey.ac.uk/842724/.

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This thesis investigates possible methods for dose reduction for one of the main contributors to medical x-ray dose, that of fluoroscopic examinations. Background information is provided on the subjects of radiation interaction mechanisms, radiation dose measures, and the health risk from medical x-rays. This illuminates a running theme of the thesis, namely the compromise between image quality and low patient dose. Possible dose reduction methods using both spatial and temporal image processing techniques are investigated. Edge detection is one of the most important sub-components of the spat

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5

Johnstone, Maria Magdalena. "Radon remediation : an analysis of dose-reduction, durability and effectiveness." Thesis, University of Northampton, 2002. http://nectar.northampton.ac.uk/2813/.

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Radon is a colourless, odourless, inert, radioactive gas found in Group 8 of the Periodic Table; it is formed by the decay of uranium in soils and rocks. The half-life of radon is 3.8 days. Radon, in the built environment, is the second largest cause of lung cancer after cigarette smoking and is responsible for 3-5% of the UK cancer deaths. Radon can accumulate in workplaces to levels (400 Bq.m3), above which action is required under UK legislation by employers to remediate so as to reduce levels and lower the risk to human health. The remediation and post-remediation research programme in the

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6

Egbe, Nneoyi Onen. "Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University members only until March, 23, 2010, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25469.

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7

Adhikari, Shishir Raj. "PLEXAR IMAGING: A STARTUP DETERMINED TO SOLVE THE CT DOSE VARIABILITY PROBLEM." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1374236161.

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8

Saunders, R. N. "The effect of rapamycin after cyclosporin dose reduction on chronic allograft nephropathy." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/29442.

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Chronic allograft nephropathy (CAN) is the commonest cause of late decline in renal allograft function and subsequent failure. Histopathologically it is underpinned by the accumulation of extracellular matrix. The first chapter provides a thorough review of the current opinions regarding the aetiology, pathophysiology and management of this complex condition. Overexposure to Cyclosporin is a major risk factor for chronic allograft nephropathy and thus Cyclosporin dose reduction has been advocated in some reports. Rapamycin is a relatively new immunosuppressant, recently introduced in renal tra

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9

Sanchez, Rene G. "Construction and operation of an in-pile loop for PWR dose reduction experiments." Thesis, Massachusetts Institute of Technology, 1990. http://hdl.handle.net/1721.1/13669.

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10

Schulz, Julia [Verfasser]. "Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency / Julia Schulz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1126504254/34.

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11

Kubo, Takeshi. "Efficiency and reproducibility in pulmonary nodule detection in simulated dose reduction lung CT images." Kyoto University, 2019. http://hdl.handle.net/2433/243276.

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12

Maués, Nadine Helena Pelegrino Bastos. "Otimização de protocolos de abdômen-pelve em tomografia computadorizada multislice utilizando associações de avaliações subjetivas e objetivas." Botucatu, 2017. http://hdl.handle.net/11449/152050.

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Orientador: Diana Rodrigues de Pina<br>Resumo: A tomografia computadorizada (TC) é amplamente utilizada no diagnóstico e estadiamento de patologias da região de abdômen-pelve devido a sua alta sensibilidade e especificidade. A possibilidade de adquirir maior número de imagens em menor tempo e a maior disponibilidade de equipamentos levaram a um aumento significativo dos exames de TC e consequente aumento das doses efetivas globais fornecidas por esta modalidade. Desta forma, foram desenvolvidas ferramentas que buscam reduzir as doses de radiação dos exames sem perda da qualidade da imagem. Uma

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13

Kraus, Laura L. "Evaluating Telepsychiatry in a Rural Skilled Nursing Facility." Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1594060357999188.

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14

Balducci, Elisa 1981. "Effect of DYRK1A dose reduction on the transcriptome of the developing mouse cerebral cortex : implications in gliogenesis." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/85057.

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Cerebral cortex is essential to exert the highest functions in mammals. Understanding the developmental processes that underlie the generation and functionality of cortical cell populations represents a mayor issue in neurobiology. DYRK1A is a dosage-sensitive gene involved in neurodevelopment with putative roles in corticogenesis. In the present study, we show that the transcriptome of the cerebral cortex of newborn mice lacking one functional copy of Dyrk1a (Dyrk1a+/-) is substantially altered and is mostly the consequence of a delayed developmental gene expression program. We also show that

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15

Balducci, Elisa. "Effect of DYRK1A dose reduction on the transcriptome of the developing mouse cerebral cortex : implications in gliogenesis." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/85057.

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Cerebral cortex is essential to exert the highest functions in mammals. Understanding the developmental processes that underlie the generation and functionality of cortical cell populations represents a mayor issue in neurobiology. DYRK1A is a dosage-sensitive gene involved in neurodevelopment with putative roles in corticogenesis. In the present study, we show that the transcriptome of the cerebral cortex of newborn mice lacking one functional copy of Dyrk1a (Dyrk1a+/-) is substantially altered and is mostly the consequence of a delayed developmental gene expression program. We also s

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16

Setlur, Nagesh Swetadri Vasan. "Improved imaging for x-ray guided interventions| A high resolution detector system and patient dose reduction technique." Thesis, State University of New York at Buffalo, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3613101.

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<p> Over the past couple of decades there has been tremendous advancements in the field of medicine and engineering technology. Increases in the level of integration between these two branches of science has led to better understanding of physiology and anatomy of a living organism, thus allowing for better understanding of diseases along with their cures and treatments. The work presented in this dissertation aims at improving the imaging aspects of x-ray image guided interventions with endovascular image guided intervention as the primary area of application. </p><p> Minimally invasive tr

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17

Luttrell, Kyle C. "An Investigation of Dose Reduction in Head and Neck CT with the Use of Organ Exposure Modulation." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1470320019.

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18

Nikolich‐Zugich, Tijana. "Effects of High Vs. Reduced‐Dose Melphalan For Autologous Bone Marrow Transplantation in Multiple Myeloma On Pulmonary Function: A Longitudinal Study." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623514.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Bone marrow transplants (BMT, also hematopoietic stem cell transplants or HSCT/SCT) are one of the greatest medical achievements of the 20th century. They offer a treatment for a host of malignant and nonmalignant hematopoietic disorders, genetic diseases and solid tumors that could otherwise be fatal. Studies have found that 60% of patients undergoing BMT develop pulmonary complications (PC), and 1/3 of those require intensive care a

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19

Hähnel, Tom, Christoph Baldow, Joëlle Guilhot, et al. "Model-based inference and classification of immunological control mechanisms from TKI cessation and dose reduction in CML patients." American Association for Cancer Research (AACR), 2020. https://tud.qucosa.de/id/qucosa%3A74320.

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Recent clinical findings in chronic myeloid leukemia (CML) patients suggest that the risk of molecular recurrence after stopping tyrosine kinase inhibitor (TKI) treatment substantially depends on an individual’s leukemia-specific immune response. However, it is still not possible to prospectively identify patients that will remain in treatment-free remission (TFR). Here, we used an ordinary differential equation (ODE) model for CML, which explicitly includes an anti-leukemic immunological effect and applied it to 21 CML patients for whom BCR-ABL1/ABL1 time courses had been quantified before an

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20

Macri, Francesco. "Optimisation des paramètres d'acquisition et de reconstruction pour une reduction de dose en tomodensitométrie dans le bilan diagnostique de douleurs thoraciques aux urgences." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT029/document.

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Le scanner a révolutionné la médecine permettant une accélération et une meilleure prise en charge du patient. La tomodensitométrie (TDM) s’accompagne d’un désavantage qui est l’augmentation du risque de cancer radio-induit des patients qui en bénéficient. La question se pose notamment aux urgences où l’emploi du scanner est de plus en plus prédominant, souvent après la réalisation d’une radiographie. Cette attitude, malgré tout justifiée dans la plupart des cas, peut s'avérer délétère. De ce fait les principes de radioprotection obligent à l’optimisation de la dose délivrée aux patients. L’in

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21

Flaspoehler, Timothy Michael. "FW-CADIS variance reduction in MAVRIC shielding analysis of the VHTR." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45743.

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In the following work, the MAVRIC sequence of the Scale6.1 code package was tested for its efficacy in calculating a wide range of shielding parameters with respect to HTGRs. One of the NGNP designs that has gained large support internationally is the VHTR. The development of the Scale6.1 code package at ORNL has been primarily directed towards supporting the current United States' reactor fleet of LWR technology. Since plans have been made to build a prototype VHTR, it is important to verify that the MAVRIC sequence can adequately meet the simulation needs of a different reactor technology

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22

Söderlund, Sarah, and Tommy Lundmark. "Strålskydd för barn vid konventionell röntgen : En litteraturstudie." Thesis, Umeå universitet, Institutionen för omvårdnad, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88785.

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Bakgrund: Forskning visar att barn är känsligare för joniserande strålning än vuxna. Röntgenundersökningar får inte utföras i onödan och nyttan med undersökningen skall överstiga dess risker. Det är viktigt att optimera röntgenundersökningar och så långt som möjligt minimera stråldoser utan att påverka det diagnostiska resultatet, då forskning visar att även låga stråldoser kan ge upphov till DNA-skador och i förlängningen orsaka cancer. Syfte: Att beskriva metoder som optimerar röntgenundersökningar och minskar stråldosen till barn vid konventionell röntgen. Metod: Litteraturstudie vars resul

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23

Zheng, Henry Public Health &amp Community Medicine Faculty of Medicine UNSW. "Walking interventions to prevent coronary heart disease in Australia - quantifying effect size, dose-response and cost reductions." Awarded by:University of New South Wales. Public Health & Community Medicine, 2009. http://handle.unsw.edu.au/1959.4/44750.

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Coronary heart disease (CHD) is the single largest cause of death in Australia. Lack of physical activity is a primary risk factor for CHD. The thesis aimed to quantify the efficacy of walking in reducing CHD risk. Meta-analyses were performed for the quantification with the application of random-effect meta-regression models. The thesis also aimed to quantify reductions in CHD-related direct healthcare costs, productivity loss and disease burden resulting from walking interventions in Australia, using the population attributable fraction model, the work and leisure models, and the consumer

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24

Morgan, Ashraf. "Measuring Radiation Dose in Computed Tomography Using Elliptic Phantom and Free-In-Air, and Evaluating Iterative Metal Artifact Reduction Algorithm." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1472078731.

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25

Tseng, Hsin-Wu. "Task-Based Image Quality Assessment in X-Ray Computed Tomography." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/593630.

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In X-Ray CT, there is always a desire to maintain the image quality while reducing the radiation dose. Recently several dose reduction approaches in both software and hardware have been developed to achieve the goal of making radiation as low as possible. Thus, the assessment of image quality becomes an important factor for routine quality control of medical X-Ray devices. In this work, task-based image quality measurements using model observers were used to evaluate the performance of X-Ray CT systems. To evaluate the dose reduction ability, detection tasks as well as combined detection and e

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26

Champciaux, Valentin. "Calcul accéléré de la dose périphérique en radiothérapie." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASP001.

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La radiothérapie représente l'un des principaux traitements dont bénéficient les patients atteints par un cancer. Elle n'est toutefois pas sans risque~: les rayonnements ionisants utilisés pour détruire la tumeur peuvent favoriser l'apparition d'effets secondaires à long terme lorsqu'ils atteignent des régions éloignées de la zone traitée. On ne dispose aujourd'hui d'aucune méthode efficace pour connaître à l'avance cette dose périphérique, qui n'est alors pas incluse dans la planification du traitement. Notamment, la simulation Monte Carlo, reconnue pour sa précision dans le domaine, est limi

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27

Sperl, Jonathan Immanuel [Verfasser], Mathias [Akademischer Betreuer] Richter, Sibylle [Akademischer Betreuer] Ziegler, and Martin [Akademischer Betreuer] Brokate. "Optimized Intensity Modulation for Dose/Noise Reduction in X-ray Computed Tomography / Jonathan Immanuel Sperl. Gutachter: Mathias Richter ; Sibylle Ziegler. Betreuer: Martin Brokate." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1016035063/34.

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28

Lukas, Steffen [Verfasser]. "Noise reduction and motion elimination in low-dose 4D myocardial computed tomography perfusion (CTP) : preliminary clinical evaluation of the ASTRA4D algorithm / Steffen Lukas." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1202042384/34.

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29

Osborne, Stephen D. "Automatic Exposure Control During Computed Tomography Scans of the Head: Effects on Dose and Image Quality." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etd/3658.

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Automatic exposure control (AEC) is effective at reducing potentially harmful radiation doses without sacrificing image quality for many types of computed tomography (CT) scans. However, there is a need for more information regarding the use of AEC for CT head scans. This study was conducted at Johnson County Community Hospital in Mountain City, TN. Preexisting adult CT head scans (n)60 were randomly selected to form 2 stratified samples, (n)30 each. One sample used a standard protocol, and the other used a protocol with a mA-modulated AEC system, Siemens CARE Dose 4D. Causal-comparative analy

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30

Harrison, Jessica Leigh. "Assessing Generic and Program-Specific Dose-Response Relations Between Engagement in Contemplative Practices and Reductions in Teachers' Occupational Stress and Burnout." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/2107.

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Teaching is a stressful, uncertain, and emotionally laden profession (Chaplain, 2008; Farber, 1999; Johnson et al., 2005). One approach to reduce psychological distress and improve well-being in teachers is through the use of mindfulness-based stress reduction (MBSR) programs. While MBSR programs have been shown in several studies to be effective with regard to improving well-being in teachers, little research has been done to date examining the relationship between program dose and outcomes. This study examines the relationship between both generic and program-specific dose and outcomes of st

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31

Borges, Lucas Rodrigues. "Método de simulação da redução da dose de radiação na mamografia digital a partir da análise das características do ruído dos equipamentos mamográficos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/18/18152/tde-24082015-074834/.

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Este trabalho tem como objetivo o desenvolvimento de um novo método para a simulação de redução da dose de radiação em imagens mamográficas clínicas. Assim, estudos sobre a influência da redução da dose de radiação no diagnóstico do câncer de mama podem ser realizados sem que o paciente se exponha a doses extras de radiação. Uma análise preliminar foi realizada para a caracterização do ruído produzido pelo equipamento mamográfico no processo de aquisição da imagem. Essa análise evidenciou a importância de um método local de simulação, uma vez que o ruído depende da posição ao longo do campo. O

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Perez, Alessandra Maia Marques Martinez. "Estudo experimental da otimização em sistemas de mamografia digital CR e DR." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/59/59135/tde-26022015-104619/.

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A recente inserção e forte avanço da mamografia digital no Brasil como ferramenta de rastreamento do câncer mamário e as evidências de outras condições de otimização, quando comparadas à mamografia convencional (tela filme), requerem que novos parâmetros de qualidade sejam incluídos e estudados, bem como que as condições de otimização sejam revistas. O objetivo deste trabalho foi determinar a técnica radiográfica otimizada para dois sistemas de detecção (CR e DR) em uso em três unidades de mamografia: Mammomat 3000 Nova (Siemens), Senographe DMR (GE) e Senographe 2000D (GE). A otimização foi c

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Koskenkari, J. (Juha). "Myocardial ischemia-reperfusion injury and systemic inflammatory response in high-risk cardiac surgery:a clinical study of the effects of high-dose glucose-insulin treatment and the use of leukocyte-depleting filter." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514282094.

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Abstract Cardiac surgery with cardiopulmonary bypass induces the activation of systemic inflammatory response syndrome (SIRS) and results in at least some degree of global myocardial ischemia. Although these responses are usually short-lived, they may lead to serious complications and organ system failures. The present study evaluated the effects of high-dose glucose-insulin (1IU/kg/h) treatment (GIK) administered with the hyperinsulinemic normoglycemic clamp technique and a leukocyte-depleting filter on markers of systemic inflammatory response and myocardial ischemia-reperfusion injury in c

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Borges, Lucas Rodrigues. "Dose savings in digital breast tomosynthesis through image processing." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/18/18152/tde-02082017-164211/.

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In x-ray imaging, the x-ray radiation must be the minimum necessary to achieve the required diagnostic objective, to ensure the patients safety. However, low-dose acquisitions yield images with low quality, which affect the radiologists image interpretation. Therefore, there is a compromise between image quality and radiation dose. This work proposes an image restoration framework capable of restoring low-dose acquisitions to achieve the quality of full-dose acquisitions. The contribution of the new method includes the capability of restoring images with quantum and electronic noise, pixel off

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Thapa, Bishnu Bahadur. "DEVELOPMENT OF A PATIENT SPECIFIC IMAGE PLANNING SYSTEM FOR RADIATION THERAPY." UKnowledge, 2013. http://uknowledge.uky.edu/physastron_etds/11.

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A patient specific image planning system (IPS) was developed that can be used to assist in kV imaging technique selection during localization for radiotherapy. The IPS algorithm performs a divergent ray-trace through a three dimensional computed tomography (CT) data set. Energy-specific attenuation through each voxel of the CT data set is calculated and imaging detector response is integrated into the algorithm to determine the absolute values of pixel intensity and image contrast. Phantom testing demonstrated that image contrast resulting from under exposure, over exposure as well as a contra

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36

Elazhar, Halima. "Dosimétrie neutron en radiothérapie : étude expérimentale et développement d'un outil personnalisé de calcul de dose Monte Carlo." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAE013/document.

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L’optimisation des traitements en radiothérapie vise à améliorer la précision de l’irradiation des cellules cancéreuses pour épargner le plus possible les organes environnants. Or la dose périphérique déposée dans les tissus les plus éloignés de la tumeur n’est actuellement pas calculée par les logiciels de planification de traitement, alors qu’elle peut être responsable de l’induction de cancers secondaires radio-induits. Parmi les différentes composantes, les neutrons produits par processus photo-nucléaires sont les particules secondaires pour lesquelles il y a un manque important de données

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Chen, Long. "Méthodes itératives de reconstruction tomographique pour la réduction des artefacts métalliques et de la dose en imagerie dentaire." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112015/document.

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Cette thèse est constituée de deux principaux axes de recherche portant sur l'imagerie dentaire par la tomographie à rayons X : le développement de nouvelles méthodes itératives de reconstruction tomographique afin de réduire les artefacts métalliques et la réduction de la dose délivrée au patient. Afin de réduire les artefacts métalliques, nous prendrons en compte le durcissement du spectre des faisceaux de rayons X et le rayonnement diffusé. La réduction de la dose est abordée dans cette thèse en diminuant le nombre des projections traitées. La tomographie par rayons X a pour objectif de rec

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Olofsson, Lennart. "Energy and intensity modulated radiation therapy with electrons." Doctoral thesis, Umeå : Department of Radiation Sciences, Radiation Physics, Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-491.

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Guerrero, Igor. "Correção do espectro de potência do ruído na simulação de redução da dose de radiação em imagens de tomossíntese digital mamária." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/18/18152/tde-27032018-141543/.

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Esse trabalho apresenta uma nova metodologia para a correção do espectro de potência do ruído no processo de simulação de aquisições de imagens de tomossíntese digital mamária (Digital Breast Tomosynthesis - DBT) com doses reduzidas de radiação. A simulação é realizada por meio da inserção de ruído quântico dependente do sinal em imagens previamente adquiridas com a dose padrão de radiação. A DBT utiliza a mesma tecnologia de raios X que a mamografia digital, porém com a capacidade de prover ao médico exames do volume tridimensional da mama, minimizando o problema de superposição de tecidos. A

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Doucet, Julie. "Développement de méthodes innovantes pour la réduction de l’effet matrice dans les dosages immuno-enzymatiques : applications pour la quantification des anticorps thérapeutiques monoclonaux et de biomarqueurs au cours des études cliniques et précliniqued=Development of innovative methods for the reduction of matrix effects in enzyme immunoassays : application to the quantification of therapeutic monoclonal antibodies and of biomarkers in support to clinical and preclinical studies." Lyon, INSA, 2010. http://theses.insa-lyon.fr/publication/2010ISAL0087/these.pdf.

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L’effet matrice est un problème récurrent dans les immunodosages. Il est dû aux interactions spécifiques et non-spécifiques qui faussent la mesure d’un analyte au sein de matrices biologiques complexes. Au cours des études cliniques, il est crucial de pouvoir mesurer de façon juste et précise dans le sang des sujets la molécule d’intérêt et les biomarqueurs associés à la pathologie ou à l’effet de cette molécule. Pour la mesure d’anticorps monoclonaux thérapeutiques (Acm), nous montrons que les sels chaotropiques combinés au dimethylsulfoxide permettent de fortement réduire les interférences n

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Abrahams, Beynon. "The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 breast carcinoma cell line." Thesis, University of the Western Cape, 2014. http://hdl.handle.net/11394/3846.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>This study investigated the effects of TKIs on the growth and proliferation of MCF-7 breast carcinoma cells in culture. MCF-7 cells were exposed to different concentrations of TKIs alone and in combination with each other. Inhibition of cell growth by TKIs used individually occurred in a dose- and time-dependent manner. When EGFR Inhibitor I, EGFR Inhibitor II/BIBX1382 and the multi-specific EGFR/ErbB-2/ErB-4 Inhibitor were used in combination with each other at equimolar log dose concentrations, the combined effects on cell growth was sign

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Tien-En, Wu, and 吳天恩. "The reduction of additive dosage through heavy metal fixation for refuse incineration fly ash." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/55303716067706121640.

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碩士<br>崑山科技大學<br>環境工程研究所<br>104<br>Incineration is the main method for waste treatment in our country. However, high-temperature incineration converts the minerals and metal salts contained in waste into metal fumes, which cool into metal solids and adhere to particles (e.g. fly ashes). This may cause heavy metal concentrations in fly ash to exceed regulations. Therefore, additional processing method are required to treat fly ashes before final disposal. Fly ash is largely buried in sanitary landfills. However, appropriate locations are limited and difficult to acquire. Therefore, the present s

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Wu, Wei-Li, and 吳偉立. "Dose Reduction for Chest Optimization-a Phantom Study." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/99941614116874330714.

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碩士<br>中臺科技大學<br>醫學影像暨放射科學系暨研究所<br>103<br>Abstract The purpose of this research was to change X-ray parameters to find the available exposure parameters combination to maintain similar images quality. A standard chest phantom was radiographed by fixing mAs at 2.3 with changing kVp at 80, 90, 100, 110, 120, and 125. A Solid state detector (PTW Diados, Germany) was used to detect entrance skin dose (ESD). 30 radiographers were invited to evaluate each image quality by Visual Grading Analysis (VGA). ANOVA, tree clustering analysis and pair t-test were applied for examining result. The consequence

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Wells, Jered R. "Correlated Polarity Noise Reduction: Development, Analysis, and Application of a Novel Noise Reduction Paradigm." Diss., 2013. http://hdl.handle.net/10161/8246.

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<p>Image noise is a pervasive problem in medical imaging. It is a property endemic to all imaging modalities and one especially familiar in those modalities that employ ionizing radiation. Statistical uncertainty is a major limiting factor in the reduction of ionizing radiation dose; patient exposure must be minimized but high image quality must also be achieved to retain the clinical utility of medical images. One way to achieve the goal of radiation dose reduction is through the use of image post processing with noise reduction algorithms. By acquiring images at lower than normal exposure fo

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Supanich, Mark Patrick. "Radiation dose reduction techniques for dynamic, contrast-enhanced cerebral Computed Tomography /." 2009. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Chuo, Yi-Yen, and 卓奕諺. "Accelerating Image Reconstruction and Dose Reduction of Helical Cone-beam Computed Tomography Using Graphics Hardware." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/78704137033592687333.

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CHEN, PO-JEN, and 陳柏仁. "The Study of Solid State Dosimeter for Image Quality and Skin Dose Reduction in Angiography." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/jw29tz.

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碩士<br>元培醫事科技大學<br>醫學影像暨放射技術系碩士班<br>107<br>Purposes: With the use of clinical interventional angiography and transcatheter arterial embolization (T.A.E) .Patients receiving interventional special photographic examinations have radiation exposure, and skin dose is a topic worth exploring. In this study, a tissue equivalent (Bolus) was used between the sources, and the dose of the incident skin measured using a solid-state illuminating dose and the image quality was evaluated using the prosthesis. Materials and Methods: In this study, a solid-state dosimeter was used as a measuring tool for digit

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Su-May and 蘇楣. "Evaluation of Limited Angle Reconstruction Methods for Dose Reduction in Cone Beam Computed Tomography Systems." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/gc867t.

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碩士<br>國立成功大學<br>生物醫學工程學系<br>105<br>Computed tomography (CT) is already an indispensable tool and widely applied in clinical diagnosis, so is cone beam computed tomography (CBCT) in maxillofacial, limb and dental applications. Radiation dose reduction of CBCT remains to be an active topic of research. In the literature, image reconstruction with limited angles can directly reduce the radiation dose, and the iterative reconstruction algorithms have superior performance on limited angles reconstruction. Although there are many kinds of iterative reconstruction algorithms, there is no systematic a

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Mussmann, B., Maryann L. Hardy, H. Jung, et al. "Renal stone detection using a low kilo-voltage paediatric CT protocol – A porcine phantom study." 2021. http://hdl.handle.net/10454/18540.

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yes<br>Introduction: Reducing tube voltage is an effective dose saving method in computed tomography (CT) assuming tube current is not concurrently increased. Recent innovations in scanner technology now enable CT tube voltage reduction to 70 kV thereby increasing opportunities for dose reduction in paediatric patients, but it is unclear if the increased image noise associated with 70 kV impacts on ability to visualise renal stones accurately. The purpose was to assess detectability of nephrolithiasis using a bespoke paediatric phantom and low kV, non-contrast CT and to assess inter-obs

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Saaymans, Martin Anthony. "Dose reduction benefits of zinc injection into the primary cooling system of a pressurized water reactor." Thesis, 2018. https://hdl.handle.net/10539/26036.

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A research report submitted to the Faculty of Science, University of the Witwatersrand, in fulfilment of the requirements for the degree of Master of Science. Johannesburg 2018.<br>Koeberg Nuclear Power Station has set itself the objective of achieving world top quartile performance in terms of dose to workers. Achieving this goal requires implementation of a number of dose reduction initiatives. One such initiative is the continuous injection of depleted zinc acetate into the primary cooling system of the plant as a means of cobalt reduction, the principal contributor to out-of-core radiatio

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