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Artigos de revistas sobre o tema "Drug-Nutraceutical Interactions"

Autor: Grafiati

Publicado: 7 de junho de 2025

Última modificação: 2 de agosto de 2025

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Endriastuti, Nialiana Endah, Masita Wulandari Suryoputri, Dewi Latifatul Ilma, and Tunggul Adi Purwonugroho. "The potential interaction between antiepileptic drugs and nutraceuticals used in pediatrics with epilepsy." Acta Pharmaciae Indonesia : Acta Pharm Indo 10, no. 1 (2022): 4352. http://dx.doi.org/10.20884/1.api.2022.10.1.4352.

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Background: The trend of using nutraceuticals in Indonesia increases every year. This study aims to describe nutraceuticals consumed in pediatrics with epilepsy as additional antiepileptic therapy and analyze their potential drug interactions. Methods: This research was a cross-sectional study with total sampling method which was carried out in the period of June to July 2020. Inclusion criteria were children with epilepsy aged 0-17 years who were members of the Indonesian Epilepsy Community, had a doctor's diagnosis of epilepsy, received oral antiepileptic medication, and took nutraceut

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Spagnuolo, Paul. "Interactions Between Nutraceutical Supplements and Standard Acute Myeloid Leukemia Chemotherapeutics." Journal of Pharmacy & Pharmaceutical Sciences 18, no. 4 (2015): 339. http://dx.doi.org/10.18433/j3m30k.

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PURPOSE: Concomitant use of nutraceuticals with chemotherapy is very common. Cancer patients self-medicate to relieve the side effects associated with chemotherapy, improve disease outcome and to regain control of their medical care. However, there is limited empirical evidence on potential drug-nutraceutical interactions and their resulting effect on chemotherapy efficacy. METHOD: To investigate drug-nutraceutical interactions we created and screened a library of commonly used nutraceuticals for their modulatory effects on the activity of cytarabine and daunorubicin, two primary chemotherapeu

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Garrido, Camila Caro, Marie Vandooren, Koen Robeyns, Damien P. Debecker, Patricia Luis, and Tom Leyssens. "Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin." Crystals 14, no. 2 (2024): 181. http://dx.doi.org/10.3390/cryst14020181.

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This study explores the co-crystallization between the drug praziquantel (PZQ) and the nutraceutical curcumin (CU). The investigation revealed two novel solid forms: a cocrystal solvate with ethyl acetate and a non-solvated cocrystal. This novel drug–nutraceutical cocrystal is a praziquantel–curcumin (2:1) cocrystal. The cocrystal solvate has ethyl acetate molecules occupying the voids with minimal interactions within the crystal lattice. The application of heat treatment induces solvent removal and prompts the transition to the non-solvated cocrystal, as highlighted by variable-temperature X-

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Blaze, Jessica. "A Comparison of Current Regulatory Frameworks for Nutraceuticals in Australia, Canada, Japan, and the United States." INNOVATIONS in pharmacy 12, no. 2 (2021): 8. http://dx.doi.org/10.24926/iip.v12i2.3694.

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The nutraceutical market is growing and the demand for products is increasing. Consumers are looking for cheaper alternatives to prescription medications as well as health products to supplement their dietary intake on a regular basis. Many countries classify these products into different categories based on their health claims. The purpose of this review is to compare and contrast the differences of regulatory frameworks in countries of similar status in regard to nutraceutical products: vitamins, minerals, herbal supplements, and probiotics. This review also takes into consideration the aspe

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Jannati, Shirin, Adiba Patel, Rajashree Patnaik, and Yajnavalka Banerjee. "Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology." International Journal of Molecular Sciences 26, no. 12 (2025): 5521. https://doi.org/10.3390/ijms26125521.

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Oleocanthal (OC), a secoiridoid phenolic compound exclusive to extra virgin olive oil (EVOO), has emerged as a promising nutraceutical with multifaceted anti-cancer properties. Despite its well-characterized anti-inflammatory and antioxidant effects, the mechanistic breadth and translational potential of OC in oncology remain underexplored and fragmented across the literature. This comprehensive review synthesizes and critically analyzes recent advances in the molecular, pharmacological, and translational landscape of OC’s anti-cancer activities, providing an integrative framework to bridge pr

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Calvani, Maura, Amada Pasha, and Claudio Favre. "Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species." International Journal of Molecular Sciences 21, no. 6 (2020): 1936. http://dx.doi.org/10.3390/ijms21061936.

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In recent years, epidemiological studies have shown that food is a very powerful means for maintaining a state of well-being and for health prevention. Many degenerative, autoimmune and neoplastic diseases are related to nutrition and the nutrient–organism interaction could define the balance between health and disease. Nutrients and dietary components influence epigenetic phenomena and modify drugs response; therefore, these food–host interactions can influence the individual predisposition to disease and its potential therapeutic response. Do nutraceuticals have positive or negative effects

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Davis, Mellar P., Bertrand Behm, Zankhana Mehta, and Carlos Fernandez. "The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review." American Journal of Hospice and Palliative Medicine® 36, no. 12 (2019): 1134–54. http://dx.doi.org/10.1177/1049909119850807.

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Palmitoylethanolamide (PEA) is a nutraceutical endocannabinoid that was retrospectively discovered in egg yolks. Feeding poor children with known streptococcal infections prevented rheumatic fever. Subsequently, it was found to alter the course of influenza. Unfortunately, there is little known about its pharmacokinetics. Palmitoylethanolamide targets nonclassical cannabinoid receptors rather than CB1 and CB2 receptors. Palmitoylethanolamide will only indirectly activate classical cannabinoid receptors by an entourage effect. There are a significant number of prospective and randomized trials

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Puri, Vivek, Manju Nagpal, Inderbir Singh, et al. "A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges." Nutrients 14, no. 21 (2022): 4637. http://dx.doi.org/10.3390/nu14214637.

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Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that are biologically active and possess capability for maintaining optimal health and benefits. These products play a significant role in human health care and its endurance, most importantly for the future therapeutic development. Nutraceuticals have received recognition due to their nutritional benefits along with therapeutic effects and safety profile. Nutraceuticals are globally growing in the field of services such as health care promotion, disease reduction, etc. Various drug nutraceutical interaction

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Persiani, S., F. Sala, C. Manzotti, et al. "An oral cocktail study on potential drug interactions of a proprietary nutraceutical combination containing berberine and monacolin in healthy volunteers." Atherosclerosis 235, no. 2 (2014): e297-e298. http://dx.doi.org/10.1016/j.atherosclerosis.2014.05.896.

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Prasad, Sakhare* Kailas Jadhao Kailash Biyani. "Classification of Nutraceuticals: From Traditional Roots to Modern Innovations." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1431–38. https://doi.org/10.5281/zenodo.15379417.

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In recent years, the increased availability of a wide variety of processed and unhealthy food products has prompted major concerns about their harmful health, environmental, and social implications. The excessive use of such foods has been related to a rise in chronic diseases, including diabetes, obesity, cancer, osteoporosis, and numerous allergy problems. In response, nutraceuticals have developed as viable solutions to improve health and enhance immunity. These bioactive chemicals, derived from food sources, have a key role in preventing disease and maintaining normal physiological activit

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Torres, Manuel, Sebastià Parets, Javier Fernández-Díaz, et al. "Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids." Membranes 11, no. 12 (2021): 919. http://dx.doi.org/10.3390/membranes11120919.

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Membranes are mainly composed of a lipid bilayer and proteins, constituting a checkpoint for the entry and passage of signals and other molecules. Their composition can be modulated by diet, pathophysiological processes, and nutritional/pharmaceutical interventions. In addition to their use as an energy source, lipids have important structural and functional roles, e.g., fatty acyl moieties in phospholipids have distinct impacts on human health depending on their saturation, carbon length, and isometry. These and other membrane lipids have quite specific effects on the lipid bilayer structure,

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Zhang, Di, Xianrui Chen, Nitong Bu, et al. "Biosynthesis of Quercetin-Loaded Melanin Nanoparticles for Improved Antioxidant Activity, Photothermal Antimicrobial, and NIR/pH Dual-Responsive Drug Release." Foods 12, no. 23 (2023): 4232. http://dx.doi.org/10.3390/foods12234232.

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Quercetin (QCT) is a promising dose-dependent nutraceutical that usually suffers from poor water solubility and low bioavailability issues. In this work, a novel QCT-loaded nanoscale delivery system was constructed based on the oxidative self-polymerization of melanin (Q@MNPs). The FT-IR, XRD, and Zeta potential analyses confirmed that QCT was successfully absorbed on the melanin nanoparticles (MNPs) via Π−Π and hydrogen bonding interactions. The encapsulation efficiency and particle size of Q@MNPs were 43.78% and 26.68 nm, respectively. Q@MNPs improved the thermal stability of QCT and the ant

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Ciccotti, Mario, Anna Raguzzini, Tommaso Sciarra, et al. "Nutraceutical-based Integrative Medicine: Adopting a Mediterranean Diet Pyramid for Attaining Healthy Ageing in Veterans with Disabilities." Current Pharmaceutical Design 24, no. 35 (2019): 4186–96. http://dx.doi.org/10.2174/1381612824666181003113444.

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Veterans with disability represent a big burden worldwide and often require long-term rehabilitation. Unhealthy dietary and lifestyle habits, including smoke and alcohol abuse, are common in veterans. In the context of integrative medicine approaches, the “complementary and alternative medicine” has been suggested for the management of chronic diseases. However, the potential risk of interaction between herbal products, dietary supplements and drugs must be considered in veterans. The Mediterranean diet has been suggested as a natural, non-pharmacological nutraceutical for healthy ageing. Alth

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Akter, Taslima, Md Rakibul Hassan Bulbul, Imran Sama-ae, et al. "Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand–Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation." Nutrients 15, no. 15 (2023): 3402. http://dx.doi.org/10.3390/nu15153402.

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This research investigated the antihypertensive effects of tamarind products and compared their potentials based on an animal model’s data verified by molecular docking, multitarget interactions, and dynamic simulation assays. GC-MS-characterized tamarind products were administered to cholesterol-induced hypertensive albino rat models. The two-week-intervened animals were dissected to collect their serum and organs and respectively subjected to analyses of their hypertension-linked markers and tissue architectures. The lead biometabolites of tamarinds interacted with eight target receptors in

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Hannan, Md Abdul, Md Ataur Rahman, Abdullah Al Mamun Sohag, et al. "Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety." Nutrients 13, no. 6 (2021): 1784. http://dx.doi.org/10.3390/nu13061784.

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Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress and inflammation, and to promote immunity, cell survival, and energy metaboli

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Muralidharan, Shruthi, A. Antony Joseph Velanganni, and Kumaran Shanmugam. "Inhibition of Breast Cancer Proteins by the Flavonoid Naringenin and its Derivative: A Molecular Docking Study." Journal of Natural Remedies 22, no. 1 (2022): 51. http://dx.doi.org/10.18311/jnr/2022/28194.

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Cancer is a multifaceted disease and is a major health burden in the world. Breast cancer is leading cause of mortality among women worldwide. Plant derived compounds have also been used in the treatment of cancer. Amongst them, flavonoids have been well documented for their therapeutic potential against cancer cells. Naringenin is a flavanone abundantly available in grapefruit and tomato among other sources. Several natural and synthetic derivatives of naringenin have been reported for anticancer activity. In this study, naringenin (Nar) and its derivative, naringenin 2-hydroxy benzoyl hydraz

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Rodríguez-Fernández, María Angélica, Fabiola Estefanía Tristán-Flores, Diana Casique-Aguirre, et al. "Virtual Screening and Molecular Dynamics of Cytokine–Drug Complexes for Atherosclerosis Therapy." International Journal of Molecular Sciences 26, no. 7 (2025): 2931. https://doi.org/10.3390/ijms26072931.

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Cardiovascular disease remains the leading global cause of mortality, largely driven by atherosclerosis, a chronic inflammatory condition characterized by lipid accumulation and immune-cell infiltration in arterial walls. Macrophages play a central role by forming foam cells and secreting pro-atherogenic cytokines, such as TNF-α, IFN-γ, and IL-1β, which destabilize atherosclerotic plaques, expanding the lipid core and increasing the risk of thrombosis and ischemia. Despite the significant health burden of subclinical atherosclerosis, few targeted therapies exist. Current treatments, including

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Ahmad, Saqlain. "India’s Growing Demand of Nutraceuticals." Asian Journal of Pharmaceutical Research and Development 12, no. 1 (2024): 126–32. http://dx.doi.org/10.22270/ajprd.v12i1.1368.

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Nutraceuticals are nutritive ingredients—a cross between food and medicine—that are physiologically active and have the power to preserve optimum health and advantages. These goods are essential to maintaining human health and well-being, especially in light of upcoming treatment advancements. Due to their safety profile, medicinal effects, and nutritional advantages, nutraceuticals have gained popularity. Global demand for nutraceuticals is rising in the areas of disease prevention, health care promotion, and other services. In this overview, several drug-nutritional interactions are addition

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Lakey-Beitia, Johant, Jagadeesh Kumar D., Muralidhar Hegde, and K. S. Rao. "Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis." International Journal of Molecular Sciences 20, no. 22 (2019): 5553. http://dx.doi.org/10.3390/ijms20225553.

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Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder that affects the aging population worldwide. Endogenous and exogenous factors are involved in triggering this complex and multifactorial disease, whose hallmark is Amyloid-β (Aβ), formed by cleavage of amyloid precursor protein by β- and γ-secretase. While there is no definitive cure for AD to date, many neuroprotective natural products, such as polyphenol and carotenoid compounds, have shown promising preventive activity, as well as helping in slowing down disease progression. In this article, we focus on the chemistr

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Shahid, Muhammad Naveed, Maryam Zawar, Adil Jamal, Bahaeldeen Babiker Mohamed, Sana Khalid, and Fayez Saeed Bahwerth. "Exploration of ACE-Inhibiting Peptides Encrypted in Artemisia annua Using In Silico Approach." BioMed Research International 2022 (May 23, 2022): 1–10. http://dx.doi.org/10.1155/2022/5367125.

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The renin-angiotensin system (RAS) is involved in body fluid regulation, but one of its enzymes, angiotensin-converting enzyme (ACE), indirectly causes hypertension by constricting blood vessels. Autoimmune illness is linked to the increased risk of hypertension and cardiovascular disease. In this study, ACE-inhibiting peptides were studied from Artemisia annua proteins. In silico hydrolysis of proteins was performed by BIOPEP-UWM using proteolytic enzymes from plant, microbial, and digestive sources. The physicochemical properties of 1160 peptides were determined using the peptide package of

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Curcio, Claudia, Antonio S. Greco, Salvatore Rizzo, et al. "Development, Optimization and Characterization of Eudraguard®-Based Microparticles for Colon Delivery." Pharmaceuticals 13, no. 6 (2020): 131. http://dx.doi.org/10.3390/ph13060131.

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Development of pH-dependent systems for colon delivery of natural active ingredients is an attractive area of research in the field of nutraceutical products. This study was focused on Eudraguard® resins, that are methacrylate copolymers approved as “food grade” by European Commission and useful for the production of food supplements. In particular, Eudraguard® Biotic (EUG-B), characterized by a pH-dependent solubility and Eudraguard® Control (EUG-C), whose chemical properties support a prolonged release of the encapsulated compounds, were tested. To obtain EUG microparticles, different prepar

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Kumari, Sapna, Anju Goyal, Madhukar Garg, Angela Antonescu, and Rakesh K. Sindhu. "Lyotropic Liquid Crystal System for Drug Delivery of Astaxanthin: Physical Characterization and Enhanced Antioxidant Potential." Crystals 13, no. 1 (2023): 142. http://dx.doi.org/10.3390/cryst13010142.

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Astaxanthin is a xanthophyll carotenoid, well known for its potent anti-inflammatory and antioxidant properties, owing to its unsaturated molecular structure. Aquatic plants and animals contain the hydrophobic carotenoid astaxanthin, which is thought to possess a number of advantageous biological traits. However, due to its weak bioavailability and low water solubility, its use as a nutraceutical in food is currently restricted. Cubosomal encapsulation has been considered an effective alternative for improving the bioavailability and solubility of hydrophobic bioactives. The current paper aime

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Tiscione, Daniele, Luca Gallelli, Irene Tamanini, et al. "Daidzein plus isolase associated with zinc improves clinical symptoms and quality of life in patients with LUTS due to benign prostatic hyperplasia: Results from a phase I-II study." Archivio Italiano di Urologia e Andrologia 89, no. 1 (2017): 12. http://dx.doi.org/10.4081/aiua.2017.1.12.

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Objective: In the last years there is a growing interest in nutraceutical substances that seems able to improve clinical symptoms in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). In this paper, we evaluated both efficacy and safety of a combination of daidzein with isolase and zinc in patients with LUTS due to BPH. Materials and methods: In a phase I-II study clinical trial we enrolled patients with clinical and instrumental diagnosis of LUTS associated to BPH that received a six-month treatment with a combination of daidzein with isolase and zinc

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ARIF AZIMI MD NOOR. "Melaleuca cajuputi Powell Essential Oil: A Review of Botanical, Phytochemical and Pharmacological Properties." Borneo Journal of Resource Science and Technology 13, no. 2 (2023): 1–12. http://dx.doi.org/10.33736/bjrst.5314.2023.

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Melaleuca cajuputi Powell essential oil (MCEO) is widely used in Malay traditional medicine for the treatment of stomach cramps, cough, acne, insect bites, thrush problems and many more. The demand for medicinal applications of MCEO is gradually increasing among the Southeast Asian community. All information regarding MCEO was collected via internet sources such as Google Scholar, Elsevier, PubMed, Baidu Scholar, Web of Science and local books. Meta-analysis method was performed to identify all publications or relevant books regarding the MCEO range from 1998 to 2021. The main bioactive compou

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Rusciano, Dario, and Paola Bagnoli. "Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases." Medicina 59, no. 7 (2023): 1334. http://dx.doi.org/10.3390/medicina59071334.

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In this review, we aim to provide an overview of the recent findings about the treatment of neovascular retinal diseases. The use of conventional drugs and nutraceuticals endowed with antioxidant and anti-inflammatory properties that may support conventional therapies will be considered, with the final aim of achieving risk reduction (prevention) and outcome improvement (cooperation between treatments) of such sight-threatening proliferative retinopathies. For this purpose, we consider a medicinal product one that contains well-defined compound(s) with proven pharmacological and therapeutic ef

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Bajpai, Anshuman. "Clitoria Ternatea: A Pharmacological Perspective on Its Therapeutic Potential and Pharmaceutical Application." International Journal for Research in Applied Science and Engineering Technology 13, no. 2 (2025): 237–41. https://doi.org/10.22214/ijraset.2025.66838.

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Clitoria ternatea, commonly known as butterfly pea, is a medicinal plant with a wide range of pharmacological properties and pharmaceutical applications. Traditionally used in Ayurveda and traditional medicine systems, C. ternatea has gained significant scientific interest due to its bioactive compounds, including flavonoids, anthocyanins, alkaloids, and peptides. The plant exhibits diverse therapeutic activities, such as antioxidant, anti-inflammatory, neuroprotective, antimicrobial, antidiabetic, and anticancer effects. Its neuroprotective properties, attributed to acetylcholinesterase inhib

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Johnson, Rabia, Dalene de Beer, Phiwayinkosi Dludla, Daneel Ferreira, Christo Muller, and Elizabeth Joubert. "Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C-glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome." Planta Medica 84, no. 09/10 (2018): 568–83. http://dx.doi.org/10.1055/s-0044-100622.

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AbstractAspalathin is a C-glucosyl dihydrochalcone that is abundantly present in Aspalathus linearis. This endemic South African plant, belonging to the Cape Floristic region, is normally used for production of rooibos, a herbal tea. Aspalathin was valued initially only as precursor in the formation of the characteristic red-brown colour of “fermented” rooibos, but the hype about the potential role of natural antioxidants to alleviate oxidative stress, shifted interest in aspalathin to its antioxidant properties and subsequently, its potential role to improve metabolic syndrome, a disease cond

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Seisdedos Benzal, Alejandro, and Alba Galán Rodríguez. "Recent developments in Canine Cognitive Dysfunction Syndrome." Pet Behaviour Science, no. 1 (April 9, 2016): 47. http://dx.doi.org/10.21071/pbs.v0i1.3996.

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<p>Canine Cognitive Dysfunction Syndrome (CCD) is a neurodegenerative disease affecting aging dogs. CCD is an underdiagnosed disease that involves at least 14% of geriatric dogs, but apparently less than 2% of diseased dogs are diagnosed. There are several physiopathological similarities between Alzheimer disease (AD) and CCD, developing amyloid-β deposits in brain parenchyma and blood vessels, brain atrophy and neuronal loss. The clinical signs lead to behavioural changes. They are unspecific and could appear as soon as seven years of age, but are more relevant in senior dogs. The abnor

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Smith, Matthew R., Carl Faingold, and John D. Mellinger. "Possible Drug-nutraceutical Interaction leading to Unexpected Sequelae after Inguinal Hernia Repair." American Journal of Case Reports 19 (July 17, 2018): 836–38. http://dx.doi.org/10.12659/ajcr.908117.

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Smilkov, Katarina, Darinka G. Ackova, Aleksandar Cvetkovski, Tatjana Ruskovska, Bojana Vidovic, and Mustafa Atalay. "Piperine: Old Spice and New Nutraceutical?" Current Pharmaceutical Design 25, no. 15 (2019): 1729–39. http://dx.doi.org/10.2174/1381612825666190701150803.

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Background: Many of the activities associated with pepper fruits have been attributed to piperine, the most active compound present in these spices. Objective: This paper aims to provide an overview of the known properties of piperine, i.e. piperine’s chemistry, its physiological activity, documented interactions as a bioenhancer and reported data concerning its toxicity, antioxidant properties and anticancer activity. Discussion: It is known that piperine possesses several properties. In its interaction with other drugs, it can act as a bioavailability enhancer; this effect is also manifested

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Panda, Nivedita, and Arpita Panda. "Piper betel - Not Just a Mouth Freshener But Also a Miraculous Herb for Healing: A Review." Asian Journal of Biology 18, no. 2 (2023): 20–33. http://dx.doi.org/10.9734/ajob/2023/v18i2340.

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Piper betle L., often known as betel vine, is a member of the Piperaceae family and is a significant cash crop for both economic and therapeutic purposes. The betle vine is most likely from Malaysia, while it is also grown in India, Sri Lanka, Bangladesh, Myanmar, and Nepal. It is grown in the districts of Balasore, Jagatsinghpur, Puri, Khordha, and Ganjam along Odisha's coast. With tremendous potential for creating jobs and improving the socioeconomic situations of rural people in India and other Asian nations, betel vine has enormous economic, medical, and nutraceutical value. However, there

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Bagwale, Akanksha* Dube Aditi. "A Review on Nutraceutical." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 3128–41. https://doi.org/10.5281/zenodo.15108821.

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The terms “nutrition” and “pharmaceutical” are combined to form the term “nutritraceutical.” Nutraceuticals are compounds with substantial health benefits that are either food or a component of food. In the prevention and treatment of illnesses, nutraceuticals and nutritional therapy—that is, nutraceuticals are complementary therapies that provide energy and nutrients while also potentially offering therapeutic benefits—have grown in popularity. Both contemporary and conventional biotechnology techniques are used in the development and production

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Chi, Ying-Chang, Shiuan-Pey Lin, and Yu-Chi Hou. "A new herb–drug interaction of Polygonum cuspidatum, a resveratrol‐rich nutraceutical, with carbamazepine in rats." Toxicology and Applied Pharmacology 263, no. 3 (2012): 315–22. http://dx.doi.org/10.1016/j.taap.2012.07.003.

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Angulo-Bejarano, Paola Isabel, María del Rocío Gómez-García, Maria Elena Valverde, and Octavio Paredes-López. "Nopal (Opuntia spp.) and its Effects on Metabolic Syndrome: New Insights for the Use of a Millenary Plant." Current Pharmaceutical Design 25, no. 32 (2019): 3457–77. http://dx.doi.org/10.2174/1381612825666191010171819.

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Background: Nopal (Opuntia spp.) is by excellence the most utilized cactus in human and animal nutrition. It is also a very noble plant; its main physicochemical, nutritional and nutraceutical characteristics allow the use of nopal in diverse food applications. Special focus has been given over the past decades in the use of Opuntia for the treatment of metabolic syndrome (MetS), which is predominantly related to Diabetes Mellitus. In this sense, the prevalence of MetS is increasing at a worldwide level. This in turn has led to a notorious demand for natural and nutraceutical food sources. Met

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Venkatachalapathi, Santhi, Balamuralikrishnan Balasubramanian, Haripriya Kuchi Bhotla, and Mohamad Fawzi Mahomoodally. "Unravelling the benefits of nutraceutical seaweed <i>Ecklonia</i> to reaping its pharmaceutical approaches." Natural Resources for Human Health 5, no. 2 (2025): 245–54. https://doi.org/10.53365/nrfhh/203180.

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Growing concern for human health has driven researchers worldwide to reap the benefits of marine algal species due to their potent, multifaceted nature and bioactivity. These are nutritionally dense sources of bioactive compounds with distinct properties. The seawater ecosystem is a treasury of secondary bioactive compounds with higher therapeutic potential and diverse uniqueness, like phlorotannin and halo compounds. Several studies have highlighted the bioactive molecules obtained from one of the brown algae, <i>Ecklonia</i>, which can reduce the activities of key regulators like

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Karimi, Isaac, Mahnaz Ghowsi, Layth Jasim Mohammed, Zohreh Haidari, Kosar Nazari, and Helgi B. Schiöth. "Inulin as a Biopolymer; Chemical Structure, Anticancer Effects, Nutraceutical Potential and Industrial Applications: A Comprehensive Review." Polymers 17, no. 3 (2025): 412. https://doi.org/10.3390/polym17030412.

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Inulin is a versatile biopolymer that is non-digestible in the upper alimentary tract and acts as a bifidogenic prebiotic which selectively promotes gut health and modulates gut–organ axes through short-chain fatty acids and possibly yet-to-be-known interactions. Inulin usage as a fiber ingredient in food has been approved by the FDA since June 2018 and it is predicted that the universal inulin market demand will skyrocket in the near future because of its novel applications in health and diseases. This comprehensive review outlines the known applications of inulin in various disciplines rangi

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Öztürk, Yusuf, and Nilgün Öztürk. "Plant- and Nutraceutical-based Approach for the Management of Diabetes and its Neurological Complications: A Narrative Review." Current Pharmaceutical Design 25, no. 33 (2019): 3536–49. http://dx.doi.org/10.2174/1381612825666191014165633.

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: Diabetes is an important metabolic disease affecting many organs and systems in the body. The nervous system is one of the body systems affected by diabetes and neuropathic complications are troublesome in diabetic patients with many consequences. As diabetes has deleterious influences almost on bodily systems, an integrative approach seems to be necessary accepting the body as a whole and integrating body systems with lifestyle and living environment. Like some traditional health systems such as Ayurveda, integrative approach includes additional modalities to overcome both diabetes and diab

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Adinortey, Michael Buenor, Justice Kwabena Sarfo, Jeffery Kwarteng, et al. "The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey." Evidence-Based Complementary and Alternative Medicine 2018 (July 25, 2018): 1–13. http://dx.doi.org/10.1155/2018/7259146.

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Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on Launaea taraxacifolia to support its medicinal uses and also unearth knowledge gaps for future studies. An

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Junghare, Mrunalini, Sejal Jain, and Ramanathan Karuppasamy. "Implementation of computational strategies to combat drug resistance in Mycobacterium tuberculosis." Research Journal of Biotechnology 18, no. 10 (2023): 1–8. http://dx.doi.org/10.25303/1810rjbt01008.

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Mycobacterium tuberculosis (MTB) is an infectious pathogen that causes tuberculosis (TB). Even though it is curable, the first-line anti-TB medication rifampicin has been a source of rising concern for human health across the globe. However, rifampicin resistance results from mutations in the RNA polymerase's binding site of the target protein. This infectious pathogen can survive in macrophages and can induce a long-lasting latent infection. The prolonged survival of mycobacterial species was achieved with the aid of serine/threonine protein kinase G (PknG) which performs a preventive role in

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Dhal, Somali, Abdullah Alhamidi, Saeed M. Al-Zahrani, Arfat Anis, and Kunal Pal. "The Influence of Emulsifiers on the Physiochemical Behavior of Soy Wax/Rice Bran Oil-Based Oleogels and Their Application in Nutraceutical Delivery." Gels 9, no. 1 (2023): 47. http://dx.doi.org/10.3390/gels9010047.

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This research evaluated the influence of stearic acid, sunflower lecithin, and sorbitan monooleate on soy wax (SYW)/rice bran oil (RBO)-based oleogels. The physiochemical behavior of oleogel samples was evaluated using colorimetry, microscopy, FTIR, mechanical, crystallization kinetics, X-ray diffraction, and a drug release investigation. The prepared oleogels were light yellow, and adding emulsifiers did not change their appearance. All oleogels showed an oil binding capacity of >98%, independent of emulsifier treatment. The surface topography revealed that emulsifiers smoothed the surface

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Tian, Yutao, Marius Aursnes, Trond Vidar Hansen, et al. "Atomic determinants of BK channel activation by polyunsaturated fatty acids." Proceedings of the National Academy of Sciences 113, no. 48 (2016): 13905–10. http://dx.doi.org/10.1073/pnas.1615562113.

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Docosahexaenoic acid (DHA), a polyunsaturated ω-3 fatty acid enriched in oily fish, contributes to better health by affecting multiple targets. Large-conductance Ca2+- and voltage-gated Slo1 BK channels are directly activated by nanomolar levels of DHA. We investigated DHA–channel interaction by manipulating both the fatty acid structure and the channel composition through the site-directed incorporation of unnatural amino acids. Electrophysiological measurements show that thepara-group of a Tyr residue near the ion conduction pathway has a critical role. To robustly activate the channel, ioni

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Zhytniakivska, O., U. Tarabara, K. Vus, V. Trusova та G. Gorbenko. "Interaction of Heavy Metals with β-Lactoglobulin: Molecular Dynamics Study". East European Journal of Physics, № 4 (8 грудня 2024): 511–17. https://doi.org/10.26565/2312-4334-2024-4-60.

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β-Lactoglobulin (β-lg), the predominant whey protein, is renowned for its nutritional and functional attributes, including its ability to bind hydrophobic and charged molecules. These properties make β-lg a promising candidate for applications such as drug delivery systems, nutraceutical carriers, and nanocomposites for environmental remediation, particularly in detecting and removing heavy metals. Despite its potential, the impact of heavy metal binding on β-lg's structure and stability remains insufficiently explored, posing challenges for its advanced applications. In this study, molecular

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Sharma, Vipin Kumar, Bhaskar Mazumder, and Vinod Nautiyal. "Rheological Characterization of Isabgol Husk, Gum Katira Hydrocolloids, and Their Blends." International Journal of Food Science 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/506591.

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The rheological parameters of Isabgol husk, gum katira, and their blends were determined in different media such as distilled water, 0.1 N HCl, and phosphate buffer (pH 7.4). The blend properties of Isabgol husk and gum katira were measured for four different percentage compositions in order to understand their compatibility in dispersion form such as 00 : 100, 25 : 50, 50 : 50, 75 : 25, and 100 : 00 in the gel strength of 1 mass%. The miscibility of blends was determined by calculating Isabgol husk-gum katira interaction parameters by Krigbaum and Wall equation. Other rheological properties w

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Verrillo, Mariavittoria, Piergiorgio Cianciullo, Vincenza Cozzolino, et al. "Oxidative Stress Response Mechanisms Sustain the Antibacterial and Antioxidant Activity of Quercus ilex." Plants 13, no. 8 (2024): 1154. http://dx.doi.org/10.3390/plants13081154.

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The development of new natural antibiotics is considered as the heart of several investigations in the nutraceutical field. In this work, leaves of Quercus ilex L. treated by tropospheric ozone (O3) and nitrogen (N) deposition, exhibited a clear antimicrobial efficacy against five multi-drug resistant (MDR) bacterial strains (two gram-positive and three gram-negative). Under controlled conditions, it was studied how simulated N deposition influences the response to O3 and the antibacterial and antioxidant activity, and antioxidant performance. The extraction was performed by ultra-pure acetone

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Marchetti, Lucia, Eleonora Truzzi, Maria Cecilia Rossi, et al. "Alginate-Based Carriers Loaded with Mulberry (Morus alba L.) Leaf Extract: A Promising Strategy for Prolonging 1-Deoxynojirimicyn (DNJ) Systemic Activity for the Nutraceutical Management of Hyperglycemic Conditions." Molecules 29, no. 4 (2024): 797. http://dx.doi.org/10.3390/molecules29040797.

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The iminosugar 1-deoxynojirimicyn (DNJ) contained in mulberry leaves has displayed systemic beneficial effects against disorders of carbohydrate metabolism. Nevertheless, its effect is impaired by the short half-life. Alginate-based carriers were developed to encapsulate a DNJ-rich mulberry extract: Ca-alginate beads, obtained by external gelation, and spray-dried alginate microparticles (SDMs). Mean size and distribution, morphology, drug loading, encapsulation efficiency, experimental yield, and release characteristics were determined for the two formulations. Ca-alginate beads and SDMs exhi

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Garrido-Ortiz, Eduardo R., and Jocksan I. Morales-Camacho. "Production of Protein Hydrolysates with Antioxidant and Antihypertensive Activity from Edible Larvae of Aegiale hesperiaris and Comadia redtenbacheri." Foods 14, no. 12 (2025): 2124. https://doi.org/10.3390/foods14122124.

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The search for sustainable and health-promoting food sources has increased interest in edible insects, which are rich in proteins and bioactive compounds with potential nutraceutical applications. In this study, we evaluated the bioactive properties of protein hydrolysates derived from Aegiale hesperiaris (maguey white worm, WW) and Comadia redtenbacheri (maguey red worm, RW), two culturally and economically significant insect species in Mexico. Hydrolysates were obtained via enzymatic treatments: either single hydrolysis with pepsin (PH) or sequential hydrolysis with pepsin followed by trypsi

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Gomes, Andresa, and Paulo José do Amaral Sobral. "Plant Protein-Based Delivery Systems: An Emerging Approach for Increasing the Efficacy of Lipophilic Bioactive Compounds." Molecules 27, no. 1 (2021): 60. http://dx.doi.org/10.3390/molecules27010060.

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The development of plant protein-based delivery systems to protect and control lipophilic bioactive compound delivery (such as vitamins, polyphenols, carotenoids, polyunsaturated fatty acids) has increased interest in food, nutraceutical, and pharmaceutical fields. The quite significant ascension of plant proteins from legumes, oil/edible seeds, nuts, tuber, and cereals is motivated by their eco-friendly, sustainable, and healthy profile compared with other sources. However, many challenges need to be overcome before their widespread use as raw material for carriers. Thus, modification approac

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Okagu, Ogadimma D., Raliat O. Abioye, and Chibuike C. Udenigwe. "Curcumin–Induced Stabilization of Protein–Based Nano-Delivery Vehicles Reduces Disruption of Zwitterionic Giant Unilamellar Vesicles." Molecules 27, no. 6 (2022): 1941. http://dx.doi.org/10.3390/molecules27061941.

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Curcumin-loaded native and succinylated pea protein nanoparticles, as well as zwitterionic giant unilamellar vesicles were used in this study as model bioactive compound loaded-nanoparticles and biomembranes, respectively, to assess bio-nano interactions. Curcumin-loaded native protein-chitosan and succinylated protein-chitosan complexes, as well as native protein-chitosan and succinylated protein-chitosan hollow, induced leakage of the calcein encapsulated in the giant unilamellar vesicles. The leakage was more pronounced with hollow protein-chitosan complexes. However, curcumin-loaded native

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Eckert, Thomas, Mahena Jährling-Butkus, Helen Louton, et al. "Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms." Marine Drugs 19, no. 10 (2021): 542. http://dx.doi.org/10.3390/md19100542.

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Osteoarthritis belongs to the most common joint diseases in humans and animals and shows increased incidence in older patients. The bioactivities of collagen hydrolysates, sulfated glucosamine and a special fatty acid enriched dog-food were tested in a dog patient study of 52 dogs as potential therapeutic treatment options in early osteoarthritis. Biophysical, biochemical, cell biological and molecular modeling methods support that these well-defined substances may act as effective nutraceuticals. Importantly, the applied collagen hydrolysates as well as sulfated glucosamine residues from mari

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Tafu, Nontsikelelo Noxolo, and Victoria A. Jideani. "Proximate, Elemental, and Functional Properties of Novel Solid Dispersions of Moringa oleifera Leaf Powder." Molecules 27, no. 15 (2022): 4935. http://dx.doi.org/10.3390/molecules27154935.

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Moringa oleifera leaf powder (MOLP) is a rich source of antioxidants, protein, minerals, vitamins, and various phytochemicals and has been used to combat malnutrition in many countries. However, despite its many benefits, MOLP has low a solubility in water, necessitating the development of ways to address this issue. To improve the solubility of MOLP, solid-dispersed Moringa oleifera leaf powders (SDMOLPs) have been developed through freeze-drying, melting, microwave irradiation, and solvent evaporation methods using polyethylene glycols (PEG4000 and PEG6000) (1:1) as hydrophilic carriers. The

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