Bibliografias temáticas / Embryo implantation

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Literatura científica selecionada sobre o tema "Embryo implantation"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 2 de março de 2023

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Artigos de revistas sobre o assunto "Embryo implantation"

Koot, Yvonne E. M., e Nick S. Macklon. "Embryo implantation". Current Opinion in Obstetrics and Gynecology 25, n.º 4 (agosto de 2013): 274–79. http://dx.doi.org/10.1097/gco.0b013e3283630d94.

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Carson, Daniel D., Indrani Bagchi, Sudhandsu K. Dey, Allen C. Enders, Asgerally T. Fazleabas, Bruce A. Lessey e Koji Yoshinaga. "Embryo Implantation". Developmental Biology 223, n.º 2 (julho de 2000): 217–37. http://dx.doi.org/10.1006/dbio.2000.9767.

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Mustafa, Snoor Jalal, e Kameel Mate Naoum. "EFFECT OF ACYCLOVIR ON EMBRYO IMPLANTATION IN MICE". Journal of Sulaimani Medical College 3, n.º 2 (1 de dezembro de 2013): 103–7. http://dx.doi.org/10.17656/jsmc.10038.

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Gou, Jinhai, Tingwenyi Hu, Lin Li, Luqi Xue, Xia Zhao, Tao Yi e Zhengyu Li. "Role of epithelial–mesenchymal transition regulated by twist basic helix-loop-helix transcription factor 2 (Twist2) in embryo implantation in mice". Reproduction, Fertility and Development 31, n.º 5 (2019): 932. http://dx.doi.org/10.1071/rd18314.

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In a previous study we found the expression of epithelial–mesenchymal transition (EMT) biomarkers, including E-cadherin and N-cadherin, was significantly altered in uterine endometrium during embryo implantation via regulation by microRNA (miRNA)-429 and protocadherin-8 (Pcdh8). As a natural continuation of the previous study, the aim of the present study was to explore the role of EMT during embryo implantation and the potential activity of twist basic helix-loop-helix transcription factor 2 (Twist2) in regulating embryo implantation. A pregnancy model was established by naturally mating adult female ICR mice with fertile males. A pseudopregnancy model was established by mating fertile female ICR mice with vasectomised males. An invitro model of embryo implantation was established by the coculture of Ishikawa and JAR spheroids. Endometrial tissue during the peri-implantation period was collected, as were Ishikawa cells, JAR cells and cocultured cells. The expression of EMT markers (E-cadherin, N-cadherin, vimentin and cytokeratin) and Twist2 was detected invivo and invitro using the western blot analysis during embryo implantation. The expression of N-cadherin and vimentin (mesenchymal markers) was upregulated in the invitro implantation model, with downregulation of E-cadherin and cytokeratin (epithelial markers) expression. The expression of N-cadherin, vimentin and Twist2 increased significantly at the implantation sites at the time of implantation (Day 5), whereas the expression of E-cadherin and cytokeratin decreased. Location of Twist2 during embryo implantation was detected by immunohistochemistry (IHC), which revealed that it was extensively expressed in endometrial glandular epithelium and luminal epithelium at implantation sites on Day 5. The effect of the expression of Twist2 on embryo implantation was evaluated by suppressing Twist2 using Twist2-short interference (si) RNA in invivo and invitro models. The numbers of implanted embryos and the implantation rate were compared invivo and invitro. Western blot analysis showed that suppression of Twist2 led to upregulation of E-cadherin and cytokeratin, accompanied by downregulation of N-cadherin and vimentin (P<0.05). The number of implanted embryos after Twist2-siRNA interference was lower than in normal pregnancy (mean (±s.d.) 2.4±0.5 vs 6.8±1.3 respectively; P<0.05). These findings suggest the involvement of EMT in embryo implantation. The suppression of Twist2 could suppress embryo implantation by regulating EMT.

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Flores, Diana, Manoj Madhavan, Savannah Wright e Ripla Arora. "Mechanical and signaling mechanisms that guide pre-implantation embryo movement". Development 147, n.º 24 (6 de novembro de 2020): dev193490. http://dx.doi.org/10.1242/dev.193490.

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ABSTRACTHow a mammalian embryo determines and arrives at its attachment site has been studied for decades, but our understanding of this process is far from complete. Using confocal imaging and image analysis, we evaluate embryo location along the longitudinal oviductal-cervical axis of murine uteri. Our analysis reveals three distinct pre-implantation phases: embryo entry, unidirectional movement of embryo clusters and bidirectional scattering and spacing of embryos. We show that unidirectional clustered movement is facilitated by a mechanical stimulus of the embryo and is regulated by adrenergic uterine smooth muscle contractions. Embryo scattering, on the other hand, depends on embryo-uterine communication reliant on the LPAR3 signaling pathway and is independent of adrenergic muscle contractions. Finally, we demonstrate that uterine implantation sites in mice are neither random nor predetermined but are guided by the number of embryos entering the uterine lumen. These studies have implications for understanding how embryo-uterine communication is key to determining an optimal implantation site necessary for the success of a pregnancy.

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Huang, Z. P., H. Yu, Z. M. Yang, W. X. Shen, J. Wang e Q. X. Shen. "Uterine expression of implantation serine proteinase 2 during the implantation period and in vivo inhibitory effect of its antibody on embryo implantation in mice". Reproduction, Fertility and Development 16, n.º 3 (2004): 379. http://dx.doi.org/10.1071/rd03102.

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The aim of the present study was to examine the uterine expression pattern of implantation serine proteinase 2 (ISP2) protein during early pregnancy in mice and the effects of anti-ISP2 antibody on embryo implantation. Expression of ISP2 protein was found to be specifically up-regulated in mouse uterine endometrial glands following the initiation of embryo implantation. Similarly, ISP2 protein expression was observed during pseudopregnancy, indicating that its expression is not embryo dependent. In other experiments, rabbit anti-ISP2 IgG was infused into the mouse uterine lumen on Day 3 or 4 of pregnancy to examine its effects on embryo implantation, whereas vehicle (saline) or unspecific rabbit IgG served as controls. The mean number of implanted embryos from anti-ISP2-IgG-treated mice was significantly lower than that from control mice. These results suggest that ISP2 may play an important role during embryo implantation.

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Gao, Weina, Xiao Tang, Zhenyan Chen, Yue Guo, Lijun Wang, Mingmin Zhang e Guangying Huang. "Effects of Acupuncture on CCL2 and CXCL8 Expression and the Subset of uNK Cells in Rats with Embryo Implantation Failure". Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/678390.

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The present study was designed to investigate the efficacy and mechanism of acupuncture treatment on embryo implantation failure in rats. The pregnant rats were randomized into normal group (N), implantation failure group (M), acupuncture treatment group (A), and progestin treatment group (W). The embryo implantation failure model was established by mifepristone. Efficacy of acupuncture treatment was evaluated by the number of implanted embryos. The expression of CCL2 and CXCL8 and the subset of uterine natural killer cells in the endometrium were detected. We demonstrated that the number of implanted embryos was dramatically reduced after mifepristone (M group) treatment, while the acupuncture (A group) and progestin (W group) treatments significantly rescued impaired embryo implantation. The protein and mRNA expressions of CCL2 and CXCL8 were significantly reduced by mifepristone treatment, but the attenuated expression of CCL2 and CXCL8 was markedly reversed by acupuncture or progestin treatment. More importantly, acupuncture and progestin could markedly increase the subset of uNK cells in rats with embryo implantation failure. These evidences suggest that acupuncture is able to modulate the endometrial immune microenvironment and thus improve embryo implantation in pregnant rats, which provides solid experimental evidence for the curative effect of acupuncture treatment on infertility.

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Benkhalifa, M., A. Demirol, T. Sari, E. Balashova, M. Tsouroupaki, Y. Giakoumakis e T. Gurgan. "Autologous embryo–cumulus cells co-culture and blastocyst transfer in repeated implantation failures: a collaborative prospective randomized study". Zygote 20, n.º 2 (7 de abril de 2011): 173–80. http://dx.doi.org/10.1017/s0967199411000062.

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SummaryIn repeated implantation failure, the co-culture of human embryos with somatic cells has been reported to promote the improvement of embryos quality, implantation and pregnancy rate. It was reported that feeder cells can be more beneficial to the oocyte and embryo by detoxifying the culture medium and supporting embryo development via different pathways. In this study, 432 patients, each with a minimum of three repeated implantation failures, were accepted for a prospective randomized study with or without autologous cumulus cell embryo co-culture and transfer at day 3 or day 5–6. We also investigated the expression of leukaemia inhibitor factor (LIF) and platelet activating factor receptor (PAF-R) on day 3 confluent cumulus cells. The statistic analysis of the data showed significant difference of implantation and clinical pregnancy rates between classical culture and day 3 compared with co-culture and day 5–6 transfer. The molecular analysis showed that cumulus cells express the LIF and the PAF-R genes and confirmed the possible positive role of growth factors and cytokines in early embryo development. Embryo co-culture systems with autologous cells can be beneficial in routine in vitro fertilization for embryo selection and implantation improvement. More molecular investigations need to be done to improve elucidation of the complex dialogue between the embryo and feeder cells prior to implantation and to understand the involved biological function and molecular process during embryo development.

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Zorina, I. M., C. M. Eldarov, S. A. Yarigina, N. P. Makarova, D. Yu Trofimov, V. Yu Smolnikova, E. A. Kalinina e M. Yu Bobrov. "Metabolomic profiling in culture media of day-5 human embryos". Biomeditsinskaya Khimiya 63, n.º 5 (2017): 385–91. http://dx.doi.org/10.18097/pbmc20176305385.

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The aim of this study was to determine the changes of metabolomic profiles in embryonic culture media (ECM) for the evaluation of quality and implantation potential of human embryos. ECM (n=163) were collected on day 5 before transfer or cryopreservation. Some embryos were used in preimplantation genetic screening for detection of aneuploidy karyotypes. Samples were subdivided into groups according to embryo morphological classification (by Gardner), genetic analysis and implantation data. ECM were extracted with methanol, precipitates were separated by centrifugation and metabolite production of individual embryo was analysed by LC-MS (the positive ion mode). After peak detection and retention time alignment, data were analysed using the PCA algorithm. MS fingerprinting analysis of embryo culture medium showed significant differences between morphologically divided groups. Intragroup comparisons did not reveal differences between subclasses. Genetic screening of embryos revealed 33 aneuploid karyotypes. It was shown that chromosome number did not affect the metabolite profiles comparing with the normal group. The culture media of embryos that were positive or negative for successful implantation showed specific signatures that allowed to distinguish embryos with different outcomes.The characterization of ECMs by LC-MS may facilitate more accurate selection of the best embryo for the implantation, improving single-embryo transfer and thus eliminating the risk and undesirable effects of multiple pregnancies.

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Bahgat, Nagwan Ahmed, e Waleed Said. "Personalized embryo transfer after endometrial receptivity array test in patients with recurrent unexplained implantation failure". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 11, n.º 3 (25 de fevereiro de 2022): 657. http://dx.doi.org/10.18203/2320-1770.ijrcog20220380.

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Background: Unexplained recurrent implantation failure is a devastating situation for both patients and the doctor treating them, with transfer of high grade euploid embryos this situation became more related to the endometrial receptivity and the interaction between the embryo and the endometrium. Till now the best way of detecting endometrial receptivity was through endometrial receptivity array of gene in endometrial tissue.Methods: A retrospective study was carried out in large IVF center in Abu Dhabi in period from 2017-2021. Patients included in the study were infertile patients with age limit of 43 years old with history of repeated IVF failure after multiple transfer trials of high grade embryos. All patients had ERA test then frozen embryo transfer of Euploid high grade embryos obtained through stimulated cycle of each patient according to Era test results.Results: 45 patients included in our study. Patients divided into 2 major groups according to Era test result. First group included patients with receptive endometrium. The second group was the patients with displaced window of implantation. Patients with receptive endometrium were 12 (26.7%) and the displaced window of implantation was found in 33 patients (73.3%). Higher pregnancy and cumulative pregnancy rate in the patients with displaced window of implantation more than the receptive group 19 (57.7%) versus 5 (41.6%) and 27 (81,8%) versus 6 (50%), but lower implantation rate in the displaced window of implantation group 6/12 (50%) versus 25/53 (47.2%) with higher miscarriage rate in the receptive group 2/6 (33.3%) versus 4/26 (14.8%), live birth and take home baby rate in the patients with displaced window of implantation 3 babies delivered to the receptive group 3/12 (25%), 24 babies to the group of displaced window of implantation 24/53 (45.3%).Conclusions: Patients with recurrent unexplained implantation failure may benefit from personalized embryo transfer after determining their window of implantations with endometrial receptivity array testing.

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Teses / dissertações sobre o assunto "Embryo implantation"

Salter, Scarlett. "Embryo signals for successful implantation". Thesis, University of Warwick, 2016. http://wrap.warwick.ac.uk/80221/.

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Human pre-implantation embryos display a high prevalence of aneuploidy and chromosomal mosaicism, unique from any other species. The decreasing incidence of aneuploidy observed between the cleavage and blastocyst stages of preimplantation embryo development infers a degree of 'self-correction' following activation of the embryonic genome. However, contrary to the previous assumption that only euploid embryos should be considered 'normal', new evidence has confirmed that mosaic embryos can result in the birth of healthy babies. Thus, aneuploidy should be viewed as an intrinsic feature of human pre-implantation embryo development, which presents a novel challenge at implantation. The endometrium must implement both positive and negative selection, in order to limit maternal investment to only viable embryos. The ability of the endometrium to act as a 'biosensor' of embryo quality has been well documented yet there is little direct evidence for the key regulators of this process. For the first time, we demonstrate a biological context for embryo biosensoring. Firstly, we discover novel embryo-secreted proteases that are enhanced at the blastocyst stage and relate to implantation outcome upon embryo transfer. Secondly, we identify corresponding protease-sensitive receptors in the endometrium, heightened during the window of implantation. By demonstrating the cleavage and de-activation of endometrial toll-like receptor 4 (TLR4) by embryo conditioned medium, we link successful implantation to a diminished inflammatory response. Furthermore, we demonstrate that TLR4 levels in the endometrium constitute a selectivity checkpoint, which is supressed in women suffering from recurrent miscarriage (RM).

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Chu, Justin Jamie. "Approaches to improving embryo implantation". Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7098/.

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Embryo implantation represents a complex process vital in ensuring the normal development of pregnancy. Whether embryo implantation is the goal of natural conception or assisted reproductive treatment, the environment within the uterine cavity must be optimised in order to increase the chance of pregnancy. This thesis uses a mixture of research methods to investigate potential approaches to improving embryo implantation. Below are the key findings from this thesis: 1. The vitamin D status in women undergoing assisted reproductive treatment is important. An interventional trial would prove or disprove the merits of vitamin D deficiency treatment in these women. 2. There is not enough evidence to suggest a clear association between vitamin D and recurrent miscarriage, however there is a strong argument for biological plausibility. 3. The use of endometrial fluid collected at the time of embryo transfer in women undergoing assisted reproductive treatments for metabolomics analysis is possible. 4. Women with hydrosalpinx associated tubal infertility should be offered salpingostomy as a treatment option as the natural conception rates are similar to that achieved in in vitro fertilisation treatment.

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Arianmanesh, Mitra. "Identification of embryo implantation-related proteins". Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165845.

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Identification of embryo implantation-related proteins Mitra Arianmanesh Embryo implantation is a complex process involving an active dialogue between the endometrium and embryo. Tightly controlled communication between the hypothalamus, pituitary, corpus luteum (CL), endometrium and embryo is essential for implantation. Unravelling molecules involved in embryo implantation is essential since implantation failure is one of the main causes of female infertility. Therefore, identification of molecular events during embryo implantation may result in enhancing implantation rates in both natural and assisted reproductive cycles, improving contraceptive design and reducing the rate of multiple pregnancies following embryo transfer in IVF cycles. Thus, in this study, sheep was used as an animal model in order to study endometrial, corpus luteal and plasma proteome changes during embryo implantation and early pregnancy. Endometrium, CLs and plasma were harvested from cyclic ewes on days 12 and 16 of the oestrous cycle (n=4 ewes/group) and from pregnant ewes on days 12, 16 and 20 of pregnancy (n=4 ewes/group). Furthermore, ovine endometrium were collected from pregnant and non-pregnant horns on days 16 (n=4) and 20 (n=4) of pregnancy to compare endometrial protein profiles of the gravid horn (in the presence of the conceptus) with the non-gravid horn (in the absence of the conceptus) in response to the conceptus to elucidate local embryo-endometrial signalling. 2DE gel, LC-MS/MS, Western blot, IHC and qRT-PCR were employed to quantify implantation processes. This study has identified proteins in the CL and endometrium with involvement in biological pathways that are fundamental for embryo implantation and gestation. In addition, it was found that the implanting embryo is capable of regulating the expression of endometrial proteins to establish an ideal environment for its implantation and establishment of pregnancy. These findings provide an addition to the field and a solid base for targeted studies to improve our understanding of implantation and its regulation.

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Griffiths, Sean Gereint. "Endometrial mucins and human embryo implantation". Thesis, Swansea University, 2013. https://cronfa.swan.ac.uk/Record/cronfa42530.

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Failure of the embryo to implant into the uterine lining results in infertility and is also the rate limiting step in FVF. The tethered, glycoprotein MUC1 is a protective cell surface receptor that has been associated with infertility. Evidence suggests MUC1 and other endometrial mucins regulate embryo implantation. Endometrial epithelia must be shielded from infection whilst permitting the recognition and implantation of the embryo. The protein backbone of MUC1 is thought to act as a scaffold for L-selectin ligands and may be integral to the initial tethering of the embryo during early implantation. Objectives The remit of this thesis was to model the expression of MUC1 and other mucins in the human endometrium using endometrial cell lines and to use atomic force microscopy to understand the role played by these proteins in shaping the non-specific and embryo specific adhesive characteristics of endometrial monolayers. If possible the proposed L-selectin implantation mechanism was to be identified and functionally characterised. Methodology This project successfully married the traditional molecular tools of quantitative PCR and immunocytochemistry with novel application of INCELL analyzer high content screening protein analysis, peak force quantitative nano-mechanical mapping atomic force microscopy and single molecule force spectroscopy atomic force microscopy to characterise the specific and non-specific surface adhesion on live endometrial monolayers. Results Firstly, immunocytochemistry and qRTPCR revealed that basal MUC1 expression was significantly higher in Hec-1-B relative to Hec-IA, Ishikawa and Hec50. Secondly, INCELL analysis qualified a distinct heterogeneous expression of MUC1 across the endometrial monolayer and delineated altered patterning following treatment with estradiol and progestins. Thirdly, we have shown a direct and proportional correlation between MUC1 expression and adhesion in live Hec-IA and Hec-IB cell monolayers. Fourthly, this work has confirmed and characterised binding of recombinant L-selectin to the endometrial epithelial cell surface. Fifthly, it is shown that L-selectin surface binding decreases following a reduction in MUC1 surface presentation. Conclusions The results implicate MUC1 as a key component of endometrial adhesion and an initial mediator of implantation with a functional patterned expression suggesting areas of altered receptivity exist across endometrial monolayers. Abnormal MUC1 expression has been shown in endometrial pathologies and unexplained infertility. The current investigation suggests MUC1 protein may assist embryo attachment by retarding it sufficiently through mechanical impedance to allow specific L-selectin binding further securing the embryo. A non-receptive endometrium may contribute towards the infertile phenotype despite repeated IVF treatments, thus novel examination of potential embryo adhesion molecules such as MUC1 may aid understanding of endometrial characteristics which prevent embryo implantation and contribute towards IVF failure.

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Kyprianou, Christos. "Morphogenesis of the early post-implantation mouse embryo". Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/290301.

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The morphogenetic events that give rise to the early post-implantation mouse embryo (egg cylinder) have not been thoroughly studied and our knowledge is restricted to "snap-shot" descriptions of embryos recovered at different stages of implantation from the mother. A central feature of the egg cylinder is the pro-amniotic cavity, which spans the embryo and participates in formation of the extraembryonic membranes. The major aims of my PhD studies have been to reveal how this cavity is formed (Aim 1) and then how the egg cylinder grows (Aim 2). In order to address how the pro-amniotic cavity forms (Aim 1), I first characterised in detail development of the architecture of the extra-embryonic ectoderm (ExE), which has to be remodelled to permit cavity formation. My findings indicate that the ExE comprises cells in direct contact with a basement membrane and cells that lie deeper in the tissue. The ExE originates in the polar trophectoderm, a monolayer covering the epiblast of the blastocyst, which expands and undergoes invagination to form a slit-like cavity. By carrying out analyses of fixed specimens and live imaging of cultured embryos, I have found that the epiblast and ExE cavity extend towards each other through the formation and resolution of multiple rosette structures. This leads to the fusion of the ExE and epiblast cavities to form the unified pro-amniotic cavity. I show that this process is dependent on signalling cues stemming from the underlying basement membrane that activate the b1-integrin signalling pathway to regulate cell polarity, ExE tissue architecture and rosette formation. In addition to the basement membrane's role in b1-integrin signalling, it also has physical functions that I characterise in the second part of my study (Aim 2). High resolution imaging revealed that the basement membrane underlying the epiblast is highly perforated during the implantation stages. These perforations are initially evenly distributed and then accumulate asymmetrically at the future posterior part of the embryo, just prior to gastrulation. Finally, I demonstrate that remodelling of the basement membrane requires the expression of matrix metalloproteinases (MMPs) in the epiblast under the control of Nodal. The anterior visceral endoderm inhibits Nodal signalling and hence MMP inhibition in the anterior. I demonstrate that activity of the MMPs and perforations in the basement membrane are essential for embryo growth. The domain of posterior basement membrane perforations persists beyond gastrulation suggesting a potential role for these perforations in primitive streak formation and extension. Together, my studies bring new important insights into the understanding of early mouse embryo morphogenesis.

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Naveed, Fatima. "Role of embryo quality in a randomised comparison of laser assisted hatching on the implantation rate of frozen thawed embryo transfer cycles". Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972044.

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Naveed, Fatima. "Role of embryo quality in a randomised comparison of laser assisted hatching on the implantation rate of frozen thawed embryo transfercycles". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972044.

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Wang, Bing, e 王冰. "A study of annexin A2 and implantation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209472.

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Implantation is a critical step in reproduction. It is complicated and well-coordinated consisting of apposition, attachment and invasion of embryo into the endometrium. The mechanism of implantation is unclear. Our previous proteomic study showed an increase of annexin A2 in the endometrium during the implantation window of mice, consistent with the increased annexin A2 expression in the receptive human endometrium. The hypothesis of this project was that annexin A2 mediatedthe embryo-endometrium attachment. The first objective was to study the spatio-temporal expression of endometrial annexin A2 immunoreactivities in humans and mice. The cyclical change in annexin A2 expression in the mouse and human reproductive cycle suggested the involvement of a steroid regulatory mechanism. Interestingly, annexinA2 was transiently expressed on the membrane between the mouse uterine luminal epithelium and the implanting embryos from Day 4 (pre-implantation) to Day 5 (post-implantation) of pregnancy. No such signal change was observed at the inter-implantation sites, showing that the implanting embryos partially regulated annexin A2 expression. These observations and the high expression of the molecule in the luminal epithelium of human endometrium in the mid-and late luteal phase were consistent with a role of annexin A2 in implantation. The second objective was to verify the action of steroids on annexin A2 expression. It was found that a combination of 6675 pmol/L of estrogen and 429.8nmol/L of progesterone increased the total and apical surface expression of annexin A2. In mice, estrogen but not progesterone, increased annexin A2 expression in the uterine luminal epithelium of ovariectomized mice. The third objective was to study the function of annexin A2 in embryo-endometrium attachment using an Ishikawa (endometrial epithelial cells)-JEG-3 trophoblast spheroids (embryo surrogate) coculture model. Knockdown of the expression of annexin A2 in either or both cell lines significantly decreased the attachment rate of the spheroids onto the endometrial cells. The suppressive action on the two cell lines was additive. The attachment was also suppressed in the presence of anti-annexin A2 antibody during coculture. Annexin A2 was also involved in mouse implantation as demonstrated by a significant decrease in implantation sites after injection of anti-annexin A2 antibody into the mouse uterine horn. The final objective was to study the action of annexin A2 as an adhesive molecule in embryo attachment. It was found that loss of P11, the binding partner of annexin A2, reduced the attachment rate of the JEG-3 spheroids probably by decreasing the translocation of annexin A2 to the surface of the endometrial cells. Recombinant P11 and annexin A2 protein failed to bind significantly to the Ishikawa cells and the JEG-3 cells. In summary, this study demonstrates the involvement of annexin A2 as an adherent molecule in the embryo-endometrium interaction.
published_or_final_version
Obstetrics and Gynaecology
Doctoral
Doctor of Philosophy

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Graham, Sarah Jane Lehar. "Novel molecular mechanisms in pre-implantation mouse embryo development". Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708487.

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Logan, Kathleen Anne. "Human endometrial epithelia in vitro". Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242442.

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Livros sobre o assunto "Embryo implantation"

Carson, Daniel D., ed. Embryo Implantation. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6.

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1949-, Chapman Michael, Grudzinskas J. G e Chard T, eds. Implantation: Biological and clinical aspects. London: Springer-Verlag, 1988.

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Bronson, Richard, ed. The Male Role in Pregnancy Loss and Embryo Implantation Failure. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18881-2.

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1932-, Yoshinaga Koji, Mori Takahide 1933- e International Congress of Endocrinology (8th : 1988 : Kyoto, Japan), eds. Development of preimplantation embryos and their environment: Proceedings of a Symposium on Development of Preimplantation Embryos and their Environment (satellite symposium of the 8th International Congress of Endocrinology), held in Kyoto, Japan, July 14-16, 1988. New York: A.R. Liss, 1989.

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1925-, Edwards R. G., Purdy Jean M e Steptoe Patrick Christopher, eds. Implantation of the human embryo: Proceedings of the second Bourn Hall meeting. London: Academic Press, 1985.

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Stanley, Glasser, Mulholland Joy, Psychoyos A, Symposium on the Endocrinology of Embryo-Endometrium Interactions (1992 : Bordeaux, France) e International Congress of Endocrinology (9th : 1992 : Nice, France), eds. Endocrinology of embryo-endometrium interactions. New York: Plenum Press, 1994.

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K, Dey S., Serono Symposia USA e Symposium on Molecular and Cellular Aspects of Periimplantation Processes (1994 : Boston, Mass.), eds. Molecular and cellular aspects of periimplantation processes. New York: Springer-Verlag, 1995.

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Sjöberg, Nils-Otto. Blastocyst development and early implantation: Proceedings of a workshop held at the University of Lund, April 22-25, 1999. Oxford: Published for the European Society of Human Reproduction and Embryology by Oxford University Press, 2000.

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Paulesu, Luana Ricci. Signal molecules in animal and human gestation. Kerala, India: Research Signpost, 2004.

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Denker, Hans-Werner. Trophoblast Invasion and Endometrial Receptivity: Novel Aspects of the Cell Biology of Embryo Implantation. Boston, MA: Springer US, 1990.

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Capítulos de livros sobre o assunto "Embryo implantation"

Jones, Howard W., Richard A. McCormick e Susan L. Crockin. "Implantation in the Human as Viewed by Canon Law, Civil Law, and Natural Reason". In Embryo Implantation, 3–11. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_1.

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Desouza, Mary M., Gulnar A. Surveyor, Xinhui Zhou, JoAnne Julian e Daniel D. Carson. "Mucins Provide a Barrier to Embryo Implantation". In Embryo Implantation, 123–31. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_10.

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Fukuda, Michiko N., Daita Nadano, Nao Suzuki e Jun Nakayama. "Potential Involvement of Trophinin, Bystin, and Tastin in Embryo Implantation". In Embryo Implantation, 132–40. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_11.

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Coutifaris, Christos, Akinyinka Omigbodun, Piotr Ziolkiewicz e John Hoyer. "Osteopontin in Human Endometrium: A Role in Endometrial Receptivity and Embryo Implantation?" In Embryo Implantation, 141–48. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_12.

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Hoffman, Loren H., D. Rachel Breinan e Gareth L. Blaeuer. "The Rabbit as a Model for Implantation: In Vivo and In Vitro Studies". In Embryo Implantation, 151–60. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_13.

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Strauss, Jerome F., e Lee-Chuan Kao. "Regulation of Trophoblast Endocrine Function: The Placenta Does Its Own Thing Transcriptionally". In Embryo Implantation, 161–66. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_14.

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Scott, Ian C., e James C. Cross. "Transcription Factors Regulating the Differentiation of the Trophoblast Cell Lineage". In Embryo Implantation, 167–81. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_15.

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Okulicz, William C., Christopher I. Ace, Janet Tast e Christopher Longcope. "Hormonal Regulation of Endometrial Gene Expression in the Rhesus Monkey". In Embryo Implantation, 185–201. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_16.

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Fazleabas, Asgerally T., Ji-Yong Julie Kim, Kathleen M. Donnelly e Harold G. Verhage. "Embryo—Maternal Dialogue in the Baboon (Papio Anubis)". In Embryo Implantation, 202–9. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_17.

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Lessey, Bruce A. "Integrins and Uterine Receptivity". In Embryo Implantation, 210–22. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-1548-6_18.

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Trabalhos de conferências sobre o assunto "Embryo implantation"

Mischi, Massimo, Nienke Kuijsters, Federica Sammali, Chiara Rabotti e Benedictus Schoot. "Feasibility of uterine speckle tracking for improved embryo implantation". In 2015 IEEE International Ultrasonics Symposium (IUS). IEEE, 2015. http://dx.doi.org/10.1109/ultsym.2015.0489.

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Al-Shami, Rania, Amantha Thathiah, Errin Lagow, Daniel Carson e Mary C. Farach-Carson. "ROLE OF OSTEOPONTIN CHARGE FORMS IN HUMAN EMBRYO IMPLANTATION". In 3rd International Conference on Osteopontin and SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) Proteins, 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.233.

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Mischi, M., C. Rabotti, N. Kuijsters e B. C. Schoot. "Quantitative ultrasound imaging of the uterus for improved embryo implantation: Preliminary study". In 2015 IEEE International Conference on Digital Signal Processing (DSP). IEEE, 2015. http://dx.doi.org/10.1109/icdsp.2015.7251874.

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Sammali, F., C. Blank, T. H. G. F. Bakkes, Y. Huang, C. Rabotti, B. C. Schoot e M. Mischi. "Prediction of embryo implantation by machine learning based on ultrasound strain imaging". In 2019 IEEE International Ultrasonics Symposium (IUS). IEEE, 2019. http://dx.doi.org/10.1109/ultsym.2019.8926228.

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Andrievskaya, Irina, Nataliya Ishutina, Inna Dovzhikova e Nikolay Prihod'ko. "METHOD FOR ASSESSMENT THE IMPAIRMENT OF EMBRYO IMPLANTATION DURING PREGNANCY COMPLICATED BY CYTOMEGALOVIRAL INFECTION BY DETERMINING CYCLOOXYGENASE-2 IN HOMOGENATE OF VILLOUS CHORION". In XIV International Scientific Conference "System Analysis in Medicine". Far Eastern Scientific Center of Physiology and Pathology of Respiration, 2020. http://dx.doi.org/10.12737/conferencearticle_5fe01d9c086109.30801383.

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A method for assessing the impairment of embryo implantation during pregnancy complicated by cytomegalovirus infection, based on the detection of cyclooxygenase 2 in the villous chorionic homogenate, is proposed

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Duy, Pham Truong, Pham Quoc Dinh, Pham Minh Chien, Giang Trung Hieu, Dao Quang Tri, Nguyen Mai Phuong, Do Minh Tuan, Le Nguyen Lam Ngoc, Bui Hong Thuy e Nguyen Van Thuan. "EFFECT OF HISTONE DEACETYLASE INHIBITORS ON POST-IMPLANTATION DEVELOPMENT OF CLONED BOVINE EMBRYO". In NGHIÊN CỨU VÀ GIẢNG DẠY SINH HỌC Ở VIỆT NAM - BIOLOGICAL RESEARCH AND TEACHING IN VIETNAM. Nhà xuất bản Khoa học tự nhiên và Công nghệ, 2022. http://dx.doi.org/10.15625/vap.2022.0066.

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Wang, Zenan, e Wei Tech Ang. "Automatic zona pellucida dissection position selection for embryo biopsy in pre-implantation genetic diagnosis". In 2014 IEEE International Conference on Robotics and Biomimetics (ROBIO). IEEE, 2014. http://dx.doi.org/10.1109/robio.2014.7090376.

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Wang, Ze Nan, Wei Tech Ang, Su Zhao e Tat Joo Teo. "Application of lateral oscillating piezo-driven micropipette in embryo biopsy for pre-implantation genetic diagnosis". In 2014 13th International Conference on Control Automation Robotics & Vision (ICARCV). IEEE, 2014. http://dx.doi.org/10.1109/icarcv.2014.7064489.

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Stein, Anat, P. F. Kraicer e Uri Oron. "Effect of low-energy laser (He-Ne) irradiation on embryo implantation rate in the rat". In BiOS Europe '97, editado por Tiina I. Karu e Anthony R. Young. SPIE, 1997. http://dx.doi.org/10.1117/12.297986.

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Eytan, Osnat, David Elad, Joseph Hartoov e Ariel J. Jaffa. "Intra-Uterine Fluid Motion Due to Myometrial Contractions: A Mechanism for Embryo Transport". In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0230.

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Abstract The initial phase of a successful pregnancy is composed of a set of transport phenomena. The detached ovum is transported to the ampulla of the fallopian tube, where fertilization may occurs. If fertilization occurred, the embryo enters the uterine cavity within three to four days of ovulation after it has grown to a ball of cells of about 100 μm in diameter. In the uterus, the embryo is conveyed with the uterine fluid for another three to four days to a successful implantation site at the fundus, which is at the upper part of the uterus. The embryo does not have a self propelling mechanism, and thus, it is passively transported with the intra-uterine fluid, which is a highly viscous liquid. Fluid movements within the uterine cavity may be induced by myometrial contractions, which have been observed in non-pregnant uteri via in vivo measurements of intra-uterine pressures and high-speed replaying ultrasound images.

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Relatórios de organizações sobre o assunto "Embryo implantation"

Kong, Xinliang, Yanfeng Liu, Guodong Tang, Zhibo Zheng, Ying Li e Fei Yan. Efficacy of intrauterine infusion therapy before embryo transfer in recurrent implantation failure: a systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, abril de 2022. http://dx.doi.org/10.37766/inplasy2022.4.0091.

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Hou, Zhijin, Fangjie Jiang, Jie Yang, Liu Yang, Zha Hao, Xiaoling Yang, Bie Jia e Yushi Meng. What is the impact of granulocyte colony-stimulating factor (G-CSF) in subcutaneous injection or intrauterine infusion and during both the fresh and frozen embryo transfer cycles on recurrent implantation failure: A systematic review and meta-analysis? INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, julho de 2021. http://dx.doi.org/10.37766/inplasy2021.7.0040.

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