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Bibliografias temáticas / Embryonic stem cells

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Literatura científica selecionada sobre o tema "Embryonic stem cells"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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Artigos de revistas sobre o assunto "Embryonic stem cells"

1

Pera, M. F., B. Reubinoff, and A. Trounson. "Human embryonic stem cells." Journal of Cell Science 113, no. 1 (2000): 5–10. http://dx.doi.org/10.1242/jcs.113.1.5.

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Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent; they share these properties with embryonic germ (EG) cells. Candidate ES and EG cell lines from the human blastocyst and embryonic gonad can differentiate into multiple types of somatic cell. The phenotype of the blastocyst-derived cell lines is very similar to that of monkey ES cells and pluripotent human embryonal carcinoma cells, but differs from that of mouse ES cells or the human germ-cell-derived stem cells. Although ou

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HOSSEINI, Hamid, and S. MOOSAVI-NEJAD. "1A34 Shock waves effects on embryonic stem cells." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2014.26 (2014): 35–36. http://dx.doi.org/10.1299/jsmebio.2014.26.35.

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3

Cezar, Gabriela Gebrin. "Embryonic Stem Cells." International Journal of Pharmaceutical Medicine 20, no. 2 (2006): 107–14. http://dx.doi.org/10.2165/00124363-200620020-00004.

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Wagner, Erwin F. "Embryonic stem cells." Current Opinion in Oncology 4 (December 1992): S2—S4. http://dx.doi.org/10.1097/00001622-199212001-00002.

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5

Rippon, H. J., and A. E. Bishop. "Embryonic stem cells." Cell Proliferation 37, no. 1 (2004): 23–34. http://dx.doi.org/10.1111/j.1365-2184.2004.00298.x.

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6

Biswas, Atindriya, and Robert Hutchins. "Embryonic Stem Cells." Stem Cells and Development 16, no. 2 (2007): 213–22. http://dx.doi.org/10.1089/scd.2006.0081.

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Etches, Robert J. "Embryonic stem cells." Lancet Oncology 2, no. 3 (2001): 131–32. http://dx.doi.org/10.1016/s1470-2045(00)00252-7.

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Hampton, Tracy. "Embryonic Stem Cells." JAMA 297, no. 5 (2007): 459. http://dx.doi.org/10.1001/jama.297.5.459-a.

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9

Morowitz, Harold. "Embryonic stem cells." Complexity 8, no. 3 (2003): 10–11. http://dx.doi.org/10.1002/cplx.10080.

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Bishop, Anne E., Lee D. K. Buttery, and Julia M. Polak. "Embryonic stem cells." Journal of Pathology 197, no. 4 (2002): 424–29. http://dx.doi.org/10.1002/path.1154.

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Teses / dissertações sobre o assunto "Embryonic stem cells"

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Nortjé, Nico. "The moral status of embryonic stem cell research in the South African context /." Link to the online version, 2007. http://hdl.handle.net/10019.1/1372.

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2

Harun, Rosliah. "Derivation of trophoblast stem cells from human embryonic stem cells." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414643.

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Montgomery, Sarah Lynn. "Impedance measurement system for embryonic stem cell and embryoid body cultures." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24661.

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Gilner, Jennifer Bushman Kirby Suzanne Lee. "Enrichment of therapeutic hematopoietic stem cell populations from embryonic stem cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1232.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pathology and Laboratory Medicine." Discipline: Pathology and Laboratory Medicine; Department/School: Medicine.

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Jurczak, Daniel. "Stemness in human embryonic stem cells." Thesis, University of Skövde, School of Life Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3509.

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<p>Stem cells are cells that have a unique ability to divide for an indefinite period. Additionally, they can give rise to a plethora of specialized cell types. The advent of high-throughput technologies made it possible to investigate gene expression on a large scale. This enabled scientists to perform comprehensive gene profiling studies of stem cells. Several authors have suggested that there might be a common set of genes that control the stemness of stem cells. In this study, we suggest that ”stemness” genes that are related to ”stemness” characteristics show a statistically significant d

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Nussbaum, Jeannette. "Embryonic stem cells for myocardial infarct repair /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/6312.

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Noisa, Parinya. "Characterization of neural progenitor/stem cells derived from human embryonic stem cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5712.

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Human embryonic stem cells (hESCs) are able to proliferate indefinitely without losing their ability to differentiate into multiple cell types of all three germ layers. Due to these fascinating properties, hESCs have promise as a robust cell source for regenerative medicine and as an in vitro model for the study of human development. In my PhD study, I have investigated the neural differentiation process of hESCs using our established protocol, identified characteristics associated with each stage of the differentiation and explored possible signalling pathways underlying these dynamic changes

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Bigdeli, Narmin. "Derivation, characterization and differentiation of feeder-free human embryonic stem cells /." Göteborg : Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, 2010. http://hdl.handle.net/2077/22353.

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Lu, Xibin, and 盧希彬. "Quantitative characterization of mouse embryonic stem cell state transition." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208049.

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Bowles, K. M. "Generation of haematopoietic cells from human embryonic stem cells." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596829.

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Culture of hESCs on murine stromal layers or in stromal free conditions as embryoid bodies results in low levels of haematopoietic cells. Here it is demonstrated that overexpression of the transcription factor HOXB4 considerably augments haematopoetic development of hESCs. Stable HOXB4 expressing hESC clones were generated by lipofection and could be maintained in the undifferentiated state for prolonged passages. Moreover, differentiation of hESCs as embryoid bodies in serum containing medium without the use of additional of cytokines led to sequential expansion of first erythroid then myeloi

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Livros sobre o assunto "Embryonic stem cells"

1

Irina, Klimanskaya, and Lanza Robert, eds. Embryonic stem cells. Elsevier Academic Press, 2006.

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2

W, Masters J. R., Palsson Bernhard, and Thomson James A. Dr, eds. Embryonic stem cells. Springer, 2007.

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3

Turksen, Kursad. Embryonic Stem Cells. Humana Press, 2001. http://dx.doi.org/10.1385/1592592414.

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4

V, Greer Erik, ed. Embryonic stem cell research. Nova Science Publishers, 2006.

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5

Chiu, Arlene, and Mahendra S. Rao. Human Embryonic Stem Cells. Humana Press, 2003. http://dx.doi.org/10.1385/1592594239.

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6

Sullivan, Stephen, Chad A. Cowan, and Kevin Eggan, eds. Human Embryonic Stem Cells. John Wiley & Sons, Ltd, 2007. http://dx.doi.org/10.1002/9780470511619.

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Chiu, Arlene Y., and Mahendra S. Rao, eds. Human Embryonic Stem Cells. Humana Press, 2003. http://dx.doi.org/10.1007/978-1-59259-423-8.

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S, Odorico Jon, Zhang S. -C, and Pedersen Roger A, eds. Human embryonic stem cells. Garland Science/BIOS Scientific Publishers, 2006.

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9

Kiessling, Ann A. Human embryonic stem cells. 2nd ed. Jones and Bartlett Publishers, 2007.

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10

1951-, Anderson Scott, ed. Human embryonic stem cells. 2nd ed. Jones and Bartlett Publishers, 2007.

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Capítulos de livros sobre o assunto "Embryonic stem cells"

1

Jones, D. Gareth. "Stem Cells: Embryonic." In Encyclopedia of Global Bioethics. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-09483-0_401.

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Jones, D. Gareth. "Stem Cells: Embryonic." In Encyclopedia of Global Bioethics. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-05544-2_401-1.

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Schwab, Manfred. "Embryonic Stem Cells." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_1861-2.

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Lewis, Philip, Edina Silajdžić, Daniel R. Brison, and Susan J. Kimber. "Embryonic Stem Cells." In Cell Engineering and Regeneration. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-08831-0_19.

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Lewis, Philip, Edina Silajdžić, Daniel R. Brison, and Susan J. Kimber. "Embryonic Stem Cells." In Cell Engineering and Regeneration. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-37076-7_19-1.

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6

Eiges, Rachel, Naomi Zak, Benjamin E. Reubinoff, and Charles S. Irving. "Embryonic Stem Cells." In Stem Cells in Regenerative Medicine. John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118846193.ch25.

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Browning, Victoria L., and Jon S. Odorico. "Embryonic Stem Cells." In Stem Cells in Endocrinology. Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-900-1:003.

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ten Have, Henk, and Maria do Céu Patrão Neves. "Stem Cells, Embryonic." In Dictionary of Global Bioethics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54161-3_477.

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9

Draper, Jonathan S., Harry Moore, and Peter W. Andrews. "Embryonal Carcinoma Cells." In Human Embryonic Stem Cells. Humana Press, 2003. http://dx.doi.org/10.1007/978-1-59259-423-8_4.

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Friedel, Roland H. "Targeting Embryonic Stem Cells." In Transgenesis Techniques. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-019-9_12.

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Trabalhos de conferências sobre o assunto "Embryonic stem cells"

1

Shu, K., H. Thatte, and M. Spector. "Chondrogenic differentiation of adult mesenchymal stem cells and embryonic stem cells." In 2009 IEEE 35th Annual Northeast Bioengineering Conference. IEEE, 2009. http://dx.doi.org/10.1109/nebc.2009.4967739.

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2

Singh, Ankur, Shalu Suri, Ted T. Lee, et al. "Adhesive Signature-Based, Label-Free Isolation of Human Pluripotent Stem Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80044.

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Generation of human induced pluripotent stem cells (hiPSCs) from fibroblasts and other somatic cells represents a highly promising strategy to produce auto- and allo-genic cell sources for therapeutic approaches as well as novel models of human development and disease1. Reprogramming protocols involve transduction of the Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc into the parental somatic cells, followed by culturing the transduced cells on mouse embryonic fibroblast (MEF) or human fibroblast feeder layers, and subsequent mechanical dissociation of pluripotent cell-like colonies for propag

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3

Sargent, Carolyn Y., Luke A. Hiatt, Sandhya Anantharaman, Eric Berson, and Todd C. McDevitt. "Cardiogenesis of Embryonic Stem Cells is Modulated by Hydrodynamic Mixing Conditions." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193129.

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Embryonic stem cells (ESCs) have the potential to differentiate into all somatic cell types and are uniquely capable of differentiating into functional cardiomyocytes; however, to effectively use ESCs for cell-based therapies to regenerate viable myocardial tissue, an improved understanding of mechanisms regulating differentiation is necessary. Currently, application of exogenous factors is commonly attempted to direct stem cell differentiation; however, progression towards controlling multiple environmental factors, including biochemical and mechanical stimuli, may result in increased differe

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4

"Establishment of embryonic stem cell-like cells in pigs." In Recent progress in swine breeding and raising technologies and cutting-edge reproductive technologies and perspectives for their usage in swine. Food and Fertilizer Technology Center for the Asian and Pacific Region, 2014. https://doi.org/10.56669/pihy7435.

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Melvin, Tracy, Nicolas Perney, Peter Horak, Neil Hanley, and James Hughes. "Optical Classification of Human Embryonic Stem Cells." In Optical Trapping Applications. OSA, 2013. http://dx.doi.org/10.1364/ota.2013.tt1d.6.

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Savchenkova, I. P., E. A. Savchenkova, and Yu A. Osipova. "Murine embryonic stem cells with equine genes." In PROCEEDINGS OF THE II INTERNATIONAL CONFERENCE ON ADVANCES IN MATERIALS, SYSTEMS AND TECHNOLOGIES: (CAMSTech-II 2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0092606.

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Pillarisetti, A., H. Ladjal, A. Ferreira, C. Keefer, and J. P. Desai. "Mechanical characterization of mouse embryonic stem cells." In 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2009. http://dx.doi.org/10.1109/iembs.2009.5333954.

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Chen, Weiqiang, Luis G. Villa-Diaz, Yubing Sun, et al. "Nanotopography Directs Fate of Human Embryonic Stem Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80222.

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Human embryonic stem cells (hESCs) have remarkable potentials for breakthroughs in future cell-based therapeutics owing to their self-renewal capability and pluripotency [1–2]. However, their intrinsic mechanosensitivity to biophysical signals from the local cellular microenvironment is not well characterized [3–4]. In this work, we introduced a simple, yet precise, microfabrication strategy for accurate control and patterning of local nanoroughness on glass surfaces using photolithography and reactive ion etching (RIE). Our results demonstrated that nanoscale topological features could provid

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Li, Lulu, Rene Schloss, Noshir Langrana, and Martin Yarmush. "Effects of Encapsulation Microenvironment on Embryonic Stem Cell Differentiation." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192587.

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Pluripotent embryonic stem cells represent a promising renewable cell source to generate a variety of differentiated cell types. Although many investigators have described techniques to effectively differentiate stem cells into different mature cell lineages, their practicality is limited by the absence of large scale processing consideration and low yields of differentiated cells. Previously we have established a murine embryonic stem cell alginate-poly-l-lysine microencapsulation differentiation system. The three-dimensional alginate microenvironment maintains cell viability, is conducive to

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Becker, Sven, Stefan Liebner, Werner Seeger, Heinrich Sauer, Wolfgang Clauss, and Robert Voswinckel. "Embryonic Stem Cells As Source For Endothelial Cells For Cell-based Therapies." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4900.

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Relatórios de organizações sobre o assunto "Embryonic stem cells"

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พฤกษานานนท์, กำธร, รัฐจักร รังสิวิวัฒน์, ปราณี นำชัยศรีค้า, วิชชุดา อานนท์กิจพานิช та ประมวล วีรุตมเสน. เซลล์ต้นกำเนิดตัวอ่อน : รายงานวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2008. https://doi.org/10.58837/chula.res.2008.24.

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เนื่องจากการใช้เซลล์พี่เลี้ยงที่แยกได้จากตัวอ่อนของหนู เพื่อเลี้ยงเซลล์ต้นกำเนิดตัวอ่อนมนุษย์ มีความเสี่ยงต่อการปนเปื้อนของเชื้อโรคที่มาจากหนู ดังนั้น การศึกษาวิจัยจึงมีจุดประสงค์เพื่อสร้างเซลล์ต้นกำเนิดตัวอ่อนมนุษย์โดยใช้เซลล์พี่เลี้ยงที่แยกได้จากคน เซลล์พี่เลี้ยงชนิดไฟโบรบลาสแยกได้จากผิวหนังบริเวณหน้าท้องของผู้หญิงที่เข้ารับการผ่าตัดทำคลอด ใช้ตัวอ่อนที่เกิดการปฎิสนธิภายนอกร่างกาย และผ่านการแช่แข็งจำนวนสิบตัวอ่อน เพื่อสร้างเซลล์ต้นกำเนิดตัวอ่อนมนุษย์กลุ่ม อินเนอร์เซลล์แมส (inner cell mass: ICM) ของตัวอ่อน 8 ตัวอ่อนถูกแยกออกจากเซลล์โทรเฟคโตเดิร์ม (trophectoderm: TE) โดยการใช้แท่งแก้วไปเปตขนาดเ

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2

Zuckerman, Kenneth S. Reparative Medicine: Production of Erythrocytes & Platelets from Human Embryonic Stem Cells. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada566171.

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Osathanon, Thanaphum, and Prasit Pavasant. Notch signaling in adipogenic differentiation of single-clone-derived mesenchymal stem cells isolated from human adipose tissue. Chulalongkorn University, 2013. https://doi.org/10.58837/chula.res.2013.5.

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Stem cells can be isolated from various tissues, including bone marrow, dental pulp, as well as adipose tissues. Due to the non-invasive isolation procedure, the adipose-derived mesenchymal stem cells (ADSCs) are introduced as an alternative stem cell source for regenerative medicine. In addition, it has been shown that Notch signaling participates in the control of ADSCs’ behavior. However, those studies were performed in the heterogeneous population of ADSCs. In the present study, human adipose tissue derived single-cell clones were isolated using a cloning ring technique and characterized f

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Lloyd, Emily. Ethical Considerations Surrounding the Use of Human Embryonic Stem Cells and Fetal Tissue in Biomedical Research. ResearchHub Technologies, Inc., 2025. https://doi.org/10.55277/researchhub.tsapos8t.

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พฤกษานานนท์, กำธร, รัฐจักร รังสิวิวัฒน์, ปราณี นำชัยศรีค้า, นิพัญจน์ อิศรเสนา ณ อยุธยา та ประมวล วีรุตมเสน. การศึกษาเชิงเปรียบเทียบลักษณะกายภาพและชีววิทยาโมเลกุลของเซลล์ต้นกำเนิดที่สร้างจากตัวอ่อนและเซลล์ร่างกายเพื่อนำไปใช้ทางคลินิก : รายงานวิจัย. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2015. https://doi.org/10.58837/chula.res.2015.23.

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เซลล์ต้นกำเนิดจากการเหนี่ยวนำ (induced pluripotent stem cells; iPSCs) สามารถสร้างได้ จากการเหนี่ยวนำเซลล์ชนิดต่าง ๆ ของร่างกาย ให้มีลักษณะทางกายภาพ และคุณสมบัติทางชีววิทยาโมเลกุลคล้ายคลึงกับเซลล์ต้นกำเนิดที่แยกจากตัวอ่อน (embryonic stem cells; ESCs) ด้วยความสามารถในการแบ่งตัวอย่างไม่จำกัด และเปลี่ยนแปลงเป็นเซลล์ที่ทำหน้าที่จำเพาะได้หลายชนิด จึงมีความพยายามในการศึกษาวิจัย โดยมีจุดประสงค์เพื่อนำเซลล์ต้นกำเนิดทั้งจากตัวอ่อน และจากการเหนี่ยวนำเซลล์ร่างกาย มาประยุกต์ใช้ ในทางการแพทย์ เช่น การปลูกถ่ายหรือการรักษาด้วยเซลล์ การทดสอบค้นคว้าหายาตัวใหม่ การศึกษานี้ คณะผู้วิจัย มีจุดประสงค์ คือ (1) แยกเซล

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Wong, E. A., and Z. Uni. Modulating intestinal cellular maturation and differentiation in broilers by in ovo feeding. United States-Israel Binational Agricultural Research and Development Fund, 2018. http://dx.doi.org/10.32747/2018.8134161.bard.

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Mortality in a broiler flock will typically range from 4-5% of the population over the course of 6- 7 weeks in the U.S. and 7-8% of the population in Israel. Suboptimal intestinal maturation and functionality are one of the major factors that contribute to early age mortality and hinder flock body weight uniformity. The development of absorptive and secretory functions is orchestrated by differentiation of cells that arise from stem cells. Supplying compounds by in ovo feeding (IOF) during late embryogenesis provides nutrients that may change the dynamics of stem cell differentiation. We hypot

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พฤกษานานนท์, กำธร, รัฐจักร รังสิวิวัฒน์, ปราณี นำชัยศรีค้า, นิพัญจน์ อิศรเสนา ณ อยุธยา та ประมวล วีรุตมเสน. การศึกษาเขิงเปรียบเทียบลักษณะกายภาพและชีววิทยาโมเลกุลของเซลล์ต้นกำเนิดที่สร้างจากตัวอ่อนและเซลล์ร่างกายเพื่อนำไปใช้คลิกนิก : รายงานวิจัย. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.16.

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เซลล์ต้นกำเนิดจากการเหนี่ยวนำ (induced pluripotent stem cells; iPSCs) สามารถสร้างได้ จากการเหนี่ยวนำเซลล์ชนิดต่าง ๆ ของร่างกาย เซลล์ต้นกำเนิดจากการเหนี่ยวนำ มีคุณสมบัติที่สำคัญคือ สามารถแบ่งตัวได้อย่างไม่จำกัด เมื่อเลี้ยงอยู่ในสภาวะ ที่เหมาะสมในห้องปฏิบัติการและยังสามารถเปลี่ยนแปลงไปเป็นเซลล์ชนิดต่าง ๆ ในร่างกายได้ทุกชนิด ดังนั้นเซลล์ต้นกำเนิดจากการเหนี่ยวนำจึงเป็นเซลล์ที่มีลักษณะทางกายภาพและชีววิทยาโมเลกุลใกล้เคียง กับเซลล์ต้นกำเนิดที่แยกจากตัวอ่อน (embryonic stem cells; ESCs) ด้วยความสามารถดังกล่าว จึงมีความพยายามในการศึกษา เพื่อจุดประสงค์ในการนำเซลล์ต้นกำเนิดทั้งจากตัวอ่อน และจากการเหนี่ยวน

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Wahl, Geoffrey M. A Novel Strategy for Isolation, Molecular and Functional Characterization of Embryonic Mammary Stem Cells Using Molecular Genetics and Microfluidic Sorting. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada488861.

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Techakumphu, Mongkol, Pranee Numchaisrika, Ratajuk Rungsiwiwat, Somchai Suwajanakorn, Kamtorn Pruksananonda, and Pramuan Virutamasen. Development of somatic cell nuclear transfer techique for biomedical and agricultural research : report. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.85.

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To develop somatic cell nuclear transfer by using the rabbit as a mode in biomedical and agricultural research. The experiments are described in nine chapters: Chapter 1: Introduction, Chapter 2: Superovulation and oocyte recipient production in rabbits, Chapter 3: A technique for adult and foetal fibroblast cell culture, for donor cell preparation in somatic nuclear transfer, Chapter 4: Preliminary studies on somatic cell nuclear transfer in rabbits, Chapter 5: In vitro development of rabbit cloned embryos using adult fibroblast cells, after post-activation treatment with cyelohexamide and 6-

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พฤกษานานนท์, กำธร, รัฐจักร รังสิวิวัฒน์, ปราณี นำชัยศรีค้า, วิชชุดา อานนท์กิจพานิช та ประมวล วีรุตมเสน. การสร้างเซลล์ต้นกำเนิดมนุษย์โดยการเหนี่ยวนำเซลล์ CD34+ โดยการใช้เลือดจากสายสะดือ : รายงานวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2011. https://doi.org/10.58837/chula.res.2011.34.

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ถึงแม้เซลล์ต้นกำเนิดของนุษย์ที่สร้างจากตัวอ่อน (human embryonic stm cells; hESCs) จะมีคุณสมบัติที่สำคัญคือสามารถเปลี่ยนแปลงไปเป็นเซลล์ต่าง ๆของร่างกาย อาจจะสามารถนำมาใช้ในการรักษาผู้ป่วยที่มีภาวะเสื่อมของเซลล์หรืออวัยวะต่าง ๆ ได้ในอนาคต แต่ข้อจำกัดที่สำคัญของการนำเซลล์ต้นกำเนิดตัวอ่อนมาใช้ คือการต่อต้านเซลล์ต้นกำเนิดตัวอ่อนโดยภูมิคุ้มกันของผู้ป่วย เนื่องจากเซลล์ต้นกำเนิดตัวอ่อน ไม่ได้สร้างมาจากเซลล์ของผุ้ป่วยเอง ในอดีตได้มีความพยายามในการนำเทคนิคการย้ายฝากนิวเคลียส (nuclear transfer) มาใช้ในการสร้างเซลล์ต้นกำเเนิดตัวอ่อน โดยย้ายนิวเคลียสจากเซลล์ร่างกายของผุ้ป่วยไปสู่ไข่ตัวรับ (recipient ooyte)

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