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Teses / dissertações sobre o tema "Enzyme activation"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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1

Eddeb, Fadel. "Stabilisation and activation of horseradish peroxidase." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294853.

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2

Aubatin, Aude. "Modulation de la réponse immune par IL4I1 : rôle dans les évènements précoces d’activation lymphocytaire T." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0069.

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Modulation de la réponse lymphocytaire T par IL4I1 - RESUME : L’enzyme Interleukin-four Induced Gene 1 (IL4I1), qui dégrade la phénylalanine, est exprimée par des cellules présentatrices d’antigène (CPA) en réponse à des stimuli pro-inflammatoires. Elle affecte la prolifération et les fonctions lymphocytaires T et pourrait donc participer au rétrocontrôle des réponses immunitaires. Cependant, les mécanismes d’action d’IL4I1 restent encore mal connus. Mon projet de thèse a comporté deux axes. Dans un premier axe, j’ai participé à la caractérisation du rôle d’IL4I1 dans la différenciation des ly

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3

Quayle, Katherine Amanda. "Mechanisms of regulation of acetyl-CoA carboxylase." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30657.

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One of the major physiological responses to insulin secretion is the activation of lipogenesis in target tissues (principally fat and liver). As acetyl-CoA carboxylase (ACC) is the rate limiting enzyme in fatty acid synthesis, the mechanisms involved in the short term regulation of this enzyme represent a pertinent model system for determining elements involved in amplification of the signals produced in response to stimulation of cells with lipogenic and counter regulatory hormones. The regulation of mammalian ACC by hormones is a complex phenomenon involving interplay between allosteric and

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4

Lee, Charles Kai-Wu. "Eurythermalism of a deep-sea symbiosis system from an enzymological aspect." The University of Waikato, 2007. http://hdl.handle.net/10289/2588.

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The recently proposed and experimentally validated Equilibrium Model provides the most detailed description of temperature's effect on enzyme catalytic activity to date. By introducing an equilibrium between Eact, the active form of enzyme, and Einact, a reversibly inactivated form of enzyme, the Equilibrium Model explains apparent enzyme activity loss at high temperatures that cannot be accounted for by irreversible thermal denaturation. The Equilibrium Model describes enzyme behavior in the presence of substrates and under assay conditions; thus its associated parameters, deltaHeq and Teq,

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5

Trinconi, Cristiana de Melo. "Investigação sobre a atividade de Ceramida Sintase em Leishmania amazonensis." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-13022012-091618/.

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A leishmaniose é uma doença parasitária de ampla distribuição e de difícil tratamento. Recentemente foi identificada a atividade leishmanicida de tamoxifeno, levando à proposta de sua utilização como alternativa para o tratamento de leishmaniose. Neste trabalho, propusemo-nos a caracterizar a atividade de ceramida sintase (CerS) em L. amazonensis e testar a interferência do tamoxifeno nesta enzima. Identificamos, no genoma de L. amazonensis, uma ORF que codifica uma proteína similar à CerS de Saccharomyces cerevisiae, com seis domínios transmembrana e um motivo Lag1 característico. A caracteri

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6

Eatock, Susan A. (Susan Amelia) Carleton University Dissertation Chemistry. "Activation and reconstitution studies of the enzyme L-Phenylalanine Hydroxylase." Ottawa, 1989.

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7

Valdivia, Ciro Pablo Kopp. "Pruebas de elaboracion de leche de soya (Glycine max (L.) Merril) y derivados proyecto de viabilidad industrial /." Diss., Cochabamba, 1998. http://contentdm.lib.byu.edu/u?/Benson,4195.

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8

Valdivia, Ciro Pablo Kopp. "Pruebas de elaboracion de leche de soya (Glycine max (L.) Merril) y derivados proyecto de viabilidad industrial /." La Paz, 1997. http://www.lib.byu.edu/valdivia.

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9

Celik, Haydar. "Enzyme-catalyzed Reductive Activation Of Anticancer Drugs Idarubicin And Mitomycin C." Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609247/index.pdf.

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Idarubicin (IDA) and mitomycin C (MC) are clinically effective quinone-containing anticancer agents used in the treatment of several human cancers. Quinone-containing anticancer drugs have the potential to undergo bioreduction by oxidoreductases to reactive species, and thereby exert their cytotoxic effects. In the present study, we investigated, for the first time, the potential of IDA, in comparison to MC, to undergo reductive activation by NADPH-cytochrome P450 reductase (P450R), NADH-cytochrome b5 reductase (b5R) and P450R-cytochrome P4502B4 (CYP2B4) system by performing both in vitro plas

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10

Lai, Chung-Jeng. "Fumarate Activation and Kinetic Solvent Isotope Effects as Probes of the NAD-Malic Enzyme Reaction." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc278864/.

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The kinetic mechanism of activation of the NAD-malic enzyme by fumarate and the transition state structure for the oxidation malate for the NAD-malic enzyme reaction have been studied. Fumarate exerts its activating effect by decreasing the off-rate for malate from the E:Mg:malate and E:Mg:NAD:malate complexes. The activation by fumarate results in a decrease in K_imalate and an increase in V/K_malate by about 2-fold, while the maximum velocity remains constant. A discrimination exists between active and activator sites for the binding of dicarboxylic acids. Activation by fumarate is proposed

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11

Murdoch, Fern E. (Fern Elizabeth). "Occurrence and Structure of an Activating Enzyme for an S6 Kinase Determined by Monoclonal Antibody Analysis." Thesis, North Texas State University, 1987. https://digital.library.unt.edu/ark:/67531/metadc798366/.

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In this study, the production of monoclonal antibodies directed against the activating enzyme for an S6 kinase is examined and described. Evidence is presented for the association of an Mr. 55,000 abd Mr. 95,000 protein with the s6 kinase. These proteins are phosphorylated in the presence of Activating Enzyme. A sequence of regulatory events for insulin-stimulated phosphorylation of ribosomal protein S6 in cells is postulated as follows: insulin activates the receptor tyrosine kinase, which phosphorylates the Mr 116,000 subunit of Activating Enzyme. The Activating Enzyme then activates the S6

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12

Kvarnlöf, Niklas. "Activation of dissolving pulps prior to viscose preparation." Doctoral thesis, Karlstad University, Faculty of Technology and Science, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-1276.

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<p>The conventional viscose manufacturing process is a mature process that needs to be improved with respect to its environmental impact and its production cost structure. Therefore a research study has been done with the aim to improve the reactivity of the dissolving pulp used, in order to reduce the chemical demand in the viscose process and thus reduce the cost and indirectly the environmental impact.</p><p>The work described in this thesis has shown that it is possible to enhance the pulp reactivity and to use less carbon disulphide in the production of viscose, while maintaining a good q

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13

Kamadurai, Hari Bascar. "Mechanistic insights into catalysis and allosteric enzyme activation in bacteriophage lambda integrase." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1172778957.

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14

Gaillard, Laetitia. "New enzyme-activated MRI contrast agents for use with prodrug activation systems." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478955.

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15

van, der Merwe Mariè. "Enzyme architecture and flexibility affect DNA topoisomerase I function." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-026-van_der_Merwe-Index.html.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2007.<br>Title from title page screen (viewed on July 29, 2008). Research advisor: Mary-Ann Bjornsti, Ph.D. Document formatted into pages (xiii, 175 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 161-175).

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16

Neal, Andrea C. "Lipid biosynthesis in eukaryotic cells : studies on enzyme activities involved in fatty acid activation and acylation /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200678.pdf.

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17

Lewis, Martin David. "Human lysosomal sulphate transport." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phl6752.pdf.

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Addendum inserted at back Includes bibliographical references (leaves 266-287). 1. Introduction -- 2. Materials and general methods -- 3. Characterisation and partial purification of the lysosomal sulphate transporter -- 4. Identification of proteins involved in lysosomal sulphate transport -- 5. The relationship between a sulphate anion transporter family and the lysosomal sulphate transporter -- 6. Investigation of sulphate transport in human skin fibroblasts -- 7. Concluding remarks

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18

Chamond, Nathalie. "Quand un mitogène est une enzyme. ." Paris 6, 2003. http://www.theses.fr/2003PA066048.

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19

Raraty, Michael Gordon Thomas. "Cytosolic calcium signals and intracellular enzyme activation in the pathogenesis of acute pancreatitis." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250238.

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20

Hummel, Matthew Aaron. "Dapsone activation of CYP2C9 allelic variants." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2767.

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Thesis (M.S.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vi, 42 p. : ill. Includes abstract. Includes bibliographical references (p. 35-42).

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21

Carilho, Torrão Rita. "The effects of the citrullinating enzyme, peptidylarginine deiminase, on the activation of T cells." Thesis, Aston University, 2017. http://publications.aston.ac.uk/31707/.

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Rheumatoid arthritis (RA) and periodontitis (PID) are two chronic inflammatory diseases associated with the modification of self-proteins by citrullinating peptidyl arginine deiminase (PAD) enzymes, leading to a loss of tolerance by the immune system. The main goal of this study was to explore the action of PAD enzymemediated citrullination on T cell membrane proteins and gene expression in relation to the T cell phenotype in PID. Effects on cells of the adaptive immune system have been less well studied in PID and the data obtained here shows that citrullination of peripheral blood mononuclea

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22

Ohta, Takehiro. "Studies on C-H Bond Activation by Dinuclear Iron and Copper Enzyme Model Complexes." Kyoto University, 2000. http://hdl.handle.net/2433/180931.

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23

Hamson, Elizabeth. "Functional Characterisation and Outcomes of Post Translational Modifications Driven by Fibroblast Activation Protein Enzyme Activity." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14891.

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Fibroblast Activation Protein (FAP) is a cellXsurface anchored dimeric protease, closely related to Dipeptidyl Peptidase (DPP) 4. This atypical serine protease has both dipeptidyl peptidase and endopeptidase activities, cleaving substrates at a postXproline bond. FAP expression is difficult to detect in nonXdiseased adult organs, but is greatly up regulated in sites of tissue remodelling, which includes liver fibrosis, lung fibrosis, atherosclerosis, arthritis, tumours and embryonic tissues. Due to its restricted expression pattern and dual enzymatic activities, FAP is emerging as a unique the

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24

Farias, Fabriana Helena Geraldo. "11 [beta]-hydroxysteroid dehydrogenase activity in feline, equine, and ossabaw swine adipose tissue." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4909.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on January 3, 2008) Includes bibliographical references.

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25

Edwards, Heather Gray. "Protection from oxidative stress in the cardiac H9C2-cell line by the transcription factor NRF2." Auburn, Ala., 2007. http://repo.lib.auburn.edu/07M%20Dissertations/GRAY-EDWARDS_HEATHER_53.pdf.

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26

Pan, Yongping. "Characterization of Low Barrier Hydrogen Bonds in Enzyme Catalysis: an Ab Initio and DFT Investigation." Thesis, University of North Texas, 1999. https://digital.library.unt.edu/ark:/67531/metadc278586/.

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Hartree-Fock, Moller-Plesset, and density functional theory calculations have been carried out using 6-31+G(d), 6-31+G(d,p) and 6-31++G(d,p) basis sets to study the properties of low-barrier or short-strong hydrogen bonds (SSHB) and their potential role in enzyme-catalyzed reactions that involve proton abstraction from a weak carbon-acid by a weak base. Formic acid/formate anion, enol/enolate and other complexes have been chosen to simulate a SSHB system. These complexes have been calculated to form very short, very short hydrogen bonds with a very low barrier for proton transfer from the dono

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27

Backlund, Maria. "Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-549-2.

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28

Freeman, Craig. "The lysosomal degradation of heparan sulphate : a comparative study of the physical and catalytic properties of the heparan sulphate degradative enzymes /." Title page, contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09phf855.pdf.

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29

Valdivia, Ciro Pablo Kopp. "Tests on the Elaboration of Soybean milk, Derivatives, and Industrial Feasibility Project." BYU ScholarsArchive, 1997. https://scholarsarchive.byu.edu/etd/5446.

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This work was done with the purpose of evaluating different forms of soybean milk processing, the product acceptance by the public, and to do a study on the feasibility for the production of milk at a small scale to be used as a nutritional supplement in school breakfasts. The soybean milk was prepared with 2 varieties "(Cristalina and Doko)" and two periods of enzymatic inactivation (Before and After) of the grain mush. The "organoleptic" quality was evaluated through surveys and its posterior statistical analysis. Parameter quality was also considered just as did the microbiologic analysis a

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30

Freitas, Debora da Silva. "Funcionalidade e caracterização das propriedades físico-químicas, biológicas e estruturais da uricase modificada por PEGlação." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-22032011-155823/.

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A PEGlação é uma bem sucedida estratégia nano-biotecnológica que envolve a ligação covalente do polietilenoglicol (PEG) a uma droga para melhorar sua farmacocinética, farmacodinâmica e perfil imunológico, e portanto, aumentar seu efeito terapêutico. Atualmente, a PEGlação é usada para modificar proteínas, peptídeos, oligonucleotídeos e fragmentos de anticorpos. A Uricase (EC 1.7.3.3, UC) é uma enzima pertencente à classe das oxidorredutases, responsável pela oxidação do ácido úrico, produzindo alantoína. Essa enzima é encontrada em muitos organismos vivos como: bactérias, leveduras, fungos,

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31

Godsmark, Grant Kenneth. "Investigation of the role of the DNA-modifying enzyme, activation-induced cytidine deaminase (AID), in cancer." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20405.

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The DNA-editing enzyme, Activation-Induced cytidine Deaminase (AID) is essential for antibody diversification and plays an important role in immunity. AID is specifically expressed in activated B-cells and mutates targeted DNA sites, diversifying the antibody repertoire. Due to its mutagenic nature, AID expression is tightly regulated, however, its overexpression has been associated with translocation of the c-MYC oncogene, a characteristic of the B-cell derived cancer, Burkitt's lymphoma (BL). Although currently uncharacterised, AID overexpression has also been implicated in non-lymphoid canc

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32

Schulte, Gunnar. "Adenosine receptor signaling and the activation of mitogen-activated protein kinases /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-299-x/.

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33

Ljusberg-Sjölander, Jenny. "Regulation of tartrate-resistant purple acid phosphatase by proteolytic processing in rat /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-208-X/.

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34

Kwok, Yuen-yuen. "Cloning and characterization of PAC1 receptor splice variants in goldfish (Carassius auratus)." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B30708072.

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35

Lambert, Richard Harlan. "Regulation of S-adenosylmethionine synthetase in the dimorphic fungus Candida albicans." Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/459231.

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Candida albicans is a dimorphic fungus exhibiting either a budding yeast or hyphal phase. A shift from the yeast phase to the hyphal phase can generally be induced by increasing the temperature of incubation from 25°C to 37°C. This shift occurs over a four hour period as approximately 90% of the yeast cells form germ tubes during this time.Interestingly, the specific activity of S-adenosylmethionine synthetase increases during the shift in vegetative cell types and begins to decrease after the 4 hour period. Utilizing the protein synthesis inhibitor tricodermin, we have demonstrated that the i

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36

Gewin, Lindy Carol. "Investigation of the mechanism by which the human papillomavirus type-16 E6 oncoprotein induces telomerase in epithelial cells /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5006.

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37

Boice, Emily. "The Role of the Propeptide and its Residues in Activation and Secretion of Elastase, an M4 Metalloprotease Secreted by Pseudomonas aeruginosa." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/217.

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Pseudomonas aeruginosa secretes several proteases associated with pathogenesis, but the most abundant and active is elastase (M4 metalloendopeptidase). Elastase (lasB), is first synthesized as a preproenzyme, with a signal peptide, an 18-kDa N-terminal propeptide, and a 33-kDa mature domain. The propeptide functions as an intramolecular chaperone that is required for the folding and secretion of elastase, but ultimately is proteolytically removed and degraded. Previous research has identified the conserved residues in the propeptide of elastase as compared to other M4 protease precursors and

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38

Al-Ali, Hassan. "Regulation of PDK1 Protein Kinase Activation by Its C-Terminal Pleckstrin Homology Domain." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/381.

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Phosphoinositide-dependent protein kinase-1 (PDK1) plays an integral role in signaling cellular growth and proliferation, one that's dependent on its ability to autophosphorylate Ser-241 in its T-loop. This process appears to have a strict requirement for its C-terminal pleckstrin homology (PH) domain. Thus, the overall objective of this work was to determine the mechanism by which the PH domain induces an active kinase conformation in unphosphorylated PDK1, capable of Ser-241 autophosphorylation. First, computational modeling and protein cross linking studies were combined with site-directed

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39

Frey, Jasmin Renate Elisabeth [Verfasser]. "Activation of acetone by sulfate-reducing bacteria : Pathway elucidation and enzyme identification in Desulfococcus biacutus / Jasmin Renate Elisabeth Frey." Konstanz : KOPS Universität Konstanz, 2017. http://d-nb.info/1191099679/34.

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40

Rascon, Alberto, Johnathon Gearin, Jun Isoe, and Roger Miesfeld. "In vitro activation and enzyme kinetic analysis of recombinant midgut serine proteases from the Dengue vector mosquito Aedes aegypti." BioMed Central, 2011. http://hdl.handle.net/10150/610098.

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BACKGROUND:The major Dengue virus vector Aedes aegypti requires nutrients obtained from blood meal proteins to complete the gonotrophic cycle. Although bioinformatic analyses of Ae. aegypti midgut serine proteases have provided evolutionary insights, very little is known about the biochemical activity of these digestive enzymes.RESULTS:We used peptide specific antibodies to show that midgut serine proteases are expressed as zymogen precursors, which are cleaved to the mature form after blood feeding. Since midgut protein levels are insufficient to purify active proteases directly from blood fe

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41

Cigna, Sara Maria. "Etude d’une enzyme de déubiquitination comme cible thérapeutique dans le Médulloblastome avec une activation de la voie Sonic Hedgehog." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS198.

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Le médulloblastome (MB) représente la tumeur maligne la plus fréquente du système nerveux chez l'enfant. Dans le laboratoire nous nous intéressons au sous-groupe avec une activation de la voie Sonic Hedgehog (SHH). Dans ce sous-groupe, l’induction de la dégradation du facteur de transcription Atoh1 par le protéasome empêche la prolifération des cellules de médulloblastome in vivo, ce qui fait d’Atoh1 une cible thérapeutique potentielle dans le cadre du MB SHH. Dans ce contexte, en utilisant une approche de purification d’Atoh1 suivie d’analyse des complexes protéiques par MudPit (Multidimensio

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42

Melo, Natalia Covre de. "Triagem de novas fontes de xilanases com atividade hidrolítica sobre os antocianosídeos de Arrabidaea chica (Humb. e Bonpl.) Verlot." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06062012-113230/.

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Com o surgimento da metagenômica, a descoberta de compostos bioativos aumentou. A Arrabidaea chica é uma planta trepadeira, usada em tatuagens pelos índios. O enriquecimento da extração dos antocianosídeos através da fermentação das folhas com xilanase de Bacillus pumilus foi estudado anteriormente. A análise qualitativa da produção de xilanase por clones de bibliotecas metagenômicas e B. pumilus SG-32 e B. firmus P1-1 foi feita com a finalidade de elaborar um método miniaturizado para encontrar novas fontes dessa enzima. Bem como avaliar o seu potencial enzimático sobre os antocianosídeos. Os

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43

Arastoo, Mohammed. "Characterisation of phospholipase C-η enzymes and their relevance to disease". Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/15698.

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Phospholipase C enzymes are a class of enzymes that catalyse the cleavage of the membrane phospholipid, phosphatidylinositol bisphosphate (PtdIns(4,5)P₂) into the second messengers, inositol trisphosphate (Ins(4,5)P₃) and diacylglycerol (DAG). Six classes of PLC enzymes have been identified based on their structure and mechanism of activation. PLCηs are the most recently identified family and consist of two isozymes, PLCη1 and PLCη2. The aim of this thesis is to further understand the mechanisms of PLCη activation, the role of PLCη2 in relation to neuritogenesis and their roles in certain dise

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44

Kwok, Yuen-yuen, and 郭圓圓. "Cloning and characterization of PAC1 receptor splice variants in goldfish (Carassius auratus)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30708072.

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45

Abhyankar, Lalita. "The effect of reducing insulin degrading enzyme in HEPG2 cells on activation of insulin receptor, IRS-1 and SHC by tyrosine phosphorylation." Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/192259.

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46

Soares, Jitesh A. A. "The Mass Of L-Pyrrolysine In Methylamine Methyltransferases And The Role Of Its Imine Bond In Catalysis." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1204576355.

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47

Lefèvre-Groboillot, David. "Reconnaissance et oxydation de N-hydroxyguanidines et de guanidines par les NO synthases de mammifères." Paris 11, 2004. http://www.theses.fr/2004PA112027.

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Les NO synthases (NOS) sont des hémoproteines à cofacteur tétrahydrobioptérine (BH4), catalysant l'oxydation de la L-arginine en N(w)-hydroxy-L-arginine puis en NO. Chez les mammifères, trois isoformes de NOS impliquées dans des phénomènes de signalisation (nNOS et eNOS) ou de défense immunitaire (iNOS) sont connues. Dans certaines situations pathophysiologiques, les NOS ne sont pas en présence de concentrations saturantes de L-arginine ou de BH4. Elles produisent alors peu de NO et ont une activité de production d'espèces activées de l'oxygène. 1. De nombreuses N-hydroxyguanidines et guanidin

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48

Chevalier, Yoan. "Développement de flavo-enzymes artificielles pour la chimie radicalaire et l’activation du dioxygène dans l’eau." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS061.

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Le sujet vise à développer des systèmes artificiels bio-inspirés capables de catalyser d'importantes réactions organiques dans l'eau, dans des conditions douces et en utilisant des réactifs inoffensifs tels que O2. Pour cela, nous envisageons de mimer les deux activités principales des flavoenzymes, qui sont capables de catalyser soit des réductions, en délivrant un flux monoélectronique à un partenaire biologique, soit des réactions d'oxydations, par activation réductrice du dioxygène, et ceci avec le même cofacteur flavinique, mais localisé dans différents échafaudages protéiques. Ce projet

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49

Morante, Estela Ynés Valencia. "Estudo do sistema BlaR/Blal e de dois operons codificando sistemas de efluxo RND em Caulobacter crescentus." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-04062012-105252/.

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O presente trabalho tem como objetivo caracterizar três agrupamentos de genes da alfa proteobactéria Caulobacter crescentus envolvidos na resposta a metais e antibióticos. Analisamos o agrupamento composto pelos genes CC1637-CC1640, que contém um sistema BlaR/BlaI de transdução de sinal, e realizamos uma análise comparativa de dois sistemas de efluxo da família RND composto pelos genes CC2720-CC2725 e CC2388-CC2390 que estariam envolvidos na resposta a metais cádmio e zinco. Mutantes simples e duplos com deleção em fase foram obtidos, e o estudo da atividade promotora foi realizado através de

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Ornelas, Flavia Gomes Illa. "Caracterização de ecto-nucleotidases na glândula pineal de ratos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-16062014-105416/.

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A glândula pineal é um órgão neuroendócrino regulado pelo fotoperíodo ambiental. Sua principal inervação é constituída por fibras simpáticas provenientes do gânglio cervical superior que, liberando noradrenalina, ativa receptores b1 adrenérgicos resultando na produção noturna de melatonina, cuja biossíntese envolve a conversão da serotonina à NAS. O ATP, co-liberado com a noradrenalina, liga-se a receptores purinérgicos presentes na pineal e leva a uma potenciação da produção de NAS. Após a liberação, o ATP sofre rápida degradação enzimática, degradação esta, funcionalmente importante, uma vez

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