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Teses / dissertações sobre o tema "Extracellular matrix Physiology"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 28 de janeiro de 2023

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1

Hipps, Deborah Sally. "Characterisation of gelatinase, a metalloproteinase involved in extracellular matrix degradation." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315125.

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2

Al-Jamal, Rehab. "The interaction between dynamic lung physiology, the extracellular matrix and mechanical strain /." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37861.

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Recently, various proteoglycans (PGs) have been identified in the lung. The first objective of this thesis was to test the hypothesis that matrix glycosaminoglycans contribute to lung tissue viscoelasticity. Lung parenchymal strips were exposed to specific glycosaminoglycans-degradating enzymes to determine whether the mechanical properties of the tissue were affected. The degradation of heparan sulphate and chondroitin/dermatan sulphate glycosaminoglycans caused significant increases in energy dissipation and dynamic resistance relative to control strips. Hyaluronidase treatment did not alter

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3

Pasternyk, Stephanie Marika 1983. "Effect of extracellular matrix and mechanical strain on airway smooth muscle." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111560.

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Airway remodeling in asthma includes alterations in extracellular matrix and airway smooth muscle (ASM) mass. For this study, ASM cells were obtained from rats that were challenged with ovalbumin (OVA) or saline (SAL) as control. OVA and SAL cells were seeded on plastic control (PC) or on plates coated with decorin or biglycan. OVA cell number was significantly increased versus SAL cells, for cells seeded on PC (48 h). A significant decrease in cell number was observed for both OVA and SAL cells seeded on decorin compared to PC cells (48 h). OVA cells, however, showed a more modest reduction i

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4

Kidd, Kameha Rae. "Angiogenesis and neovascularization in association with extracellular matrix protein modified biomaterials." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/279992.

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Synthetic biomedical implants are used to replace diseased tissues and organs. Unfortunately, these implants often fail due to a lack of biocompatibility and poor integration by the recipient. This implant failure is associated with the formation of an avascular fibrous capsule and chronic inflammatory response. Additionally, small diameter vascular grafts have complications associated with surface thrombogenenicity and intimal hyperplasia. Porous polymers are often incorporated in the construction of biomedical devices because they permit tissue integration and improved biocompatibility. Whil

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5

Cambell, Stephen Sean. "Morphology and histochemistry of the extracellular matrix of embryos following freeze substitution of the starfish Pisaster ochraceus." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28938.

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All developing embryos contain an extracellular matrix (ECM) consisting of proteins, glycoproteins, and proteoglycans. These components are important for morphogenetic processes such as cell migration, cell differentiation and cell death. The ECM of the starfish, Pisaster ochraceus, consists of three major components: A hyaline layer which coats the external surface of the embryo; a basal lamina which lines the basal surfaces of the epithelia; and a blastocoelic component which fills the embryonic cavity or blastocoel. Observations of chemically fixed asteroid embryos have revealed the hyalin

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6

Yu, Xuefeng. "Mechanism of osteoclast migration : effect of chemoattractant cytokines, extracellular matrix proteins, and proteinase inhibitors." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287659.

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7

Nieves, Daniel. "Probing the structure of the extracellular matrix using gold nanoparticle based single molecule microscopy." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/16533/.

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The observation of single biomolecules via optical microscopy eliminates all the implicit averaging of ensemble techniques and thereby provides access to the heterogeneity of molecular systems that will be the key to at least some biological functions. The implementation of photothermal microscopy at the University of Liverpool to achieve the detection of single gold nanoparticles over long times at high signal-to-noise-ratio is presented here, along with the development of Photothermal Raster Image Correlation Spectroscopy, PhRICS. PhRICS was shown to be equally effective as Photothermal Abso

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8

Roy, Joy. "Extracellular matrix-mediated signaling in the regulation of vascular smooth muscle cell phenotype and function /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4877-1/.

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9

McGuire, Vincent Michael. "Assembly and function of the PsB multiprotein complex during spore differentiation in Dictyostelium discoideum /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9737858.

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10

Saban, Melissa. "The effect of extracellular matrix on airway smooth muscle cell contractile protein expression and calcium response to serotonin." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103604.

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The asthmatic airway wall is characterized by airway remodeling, including changes in the extracellular matrix (ECM) and increased airway smooth muscle (ASM) cell mass. Further, asthmatic ASM has been shown to demonstrate enhanced contractility. Recently, we and others have shown that alterations in the matrix upon which ASM cells are grown in culture, can affect the degree of ASM cell proliferation and apoptosis. Whether changes in matrix can affect ASM cell contractility is less clear. ASM cells were isolated from the trachea of Brown Norway (BN) rats sensitized subcutaneously with ovalbumi

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11

Horobin, Adele Jayne. "Maggots and wound healing : the effects of Lucilia sericata larval secretions upon interactions between human dermal fibroblasts and extracellular matrix proteins." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/11516/.

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The introduction of necrophagous fly larvae (maggots) into chronic wounds for the purpose of inducing healing is an ancient practice that has recently undergone a renaissance in Western medicine. Through clinical observations, maggots are broadly recognised to debride the wound of necrotic tissue, cleanse the wound of infection and promote granulation tissue formation. Despite such recognition, little research at the biological level has been undertaken to identify the mechanisms by which maggots accomplish such feats. The dermal fibroblast is a major cellular component of granulation tissue a

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12

Almeida, Fernanda Martins de. "Efeitos do alongamento sobre a matriz extracelular do tendão calcanear de ratos." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317445.

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Orientador: Edson Rosa Pimentel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-06T17:20:03Z (GMT). No. of bitstreams: 1 Almeida_FernandaMartinsde_M.pdf: 1290451 bytes, checksum: c386eaff7996cd60bd0cc59338f8718f (MD5) Previous issue date: 2006<br>Resumo: Os tendões servem para realizar a transferência de força dos músculos para os ossos, sendo capazes de suportar altas forças de tensão. Muitos trabalhos descreveram alterações nas propriedades estruturais, bioquímicas e biomecânicas dos tendões de animais que foram su

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13

Davis, Danisha Marie, Suman Dalal, Connor James, Cerrone R. Foster, and Krishna Singh. "The Role of Osteopontin in Extracellular Matrix Remodeling Following Chronic Sympathetic Stimulation in The Aging Heart." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/122.

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Cardiovascular disease (CVD) is the leading cause of death in the United States. A common feature in most cardiac pathologies is the dysregulation of beta-adrenergic receptors (β-AR) and changes in the extracellular matrix (ECM). The ECM maintains strength and normal organization of cardiac tissue, while fibrosis (connective tissue scarring) is necessary for repair of damaged cardiac tissue. However, the dysregulation of the ECM leads to a number of cardiac disease pathologies. Osteopontin (OPN) is a protein with diverse biological functions in regulating the ECM such as bone resorption and ca

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14

De, Angelis Daniel. "Syndecan-1 expression during postnatal tooth and oral mucosa development in 2 day to 6 week old rats." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09DM/09dmd284.pdf.

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Includes bibliographical references (leaves 68-76) Aims to observe changes in the expression of syndecan-1 in both the developing epithelium of the rat oral mucosa, and in epithelial cell rests of Malassez in the developing periodontium of normal rat molars, from late crown development through to early eruption.

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15

Naugle, Jennifer Elaine. "Regulation of cardiac fibroblast function via cyclic AMP, collagen I, III, and VI implications for post-myocardial infarction remodeling /." Kent State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=kent1152897621.

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16

Kwong, Wai-hang, and 鄺偉恒. "Functional analyses on TGF{221}/BMP signaling and type IIA procollagenin inner ear development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43815601.

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17

Hoyt, Laurie Christine. "Fibroblast Migration Mediated by the Composition of Tissue Engineered Scaffolds." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/164.

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Tissue engineered scaffolds were constructed to mimic the native extracellular matrix (ECM) and promote cell migration of keratinocytes and fibroblasts. Electrospinning technology was used to fabricate these nano-scale matrices that consist of varying compositions and fiber diameters. The purpose of this study was to examine how average fiber diameter and scaffold composition regulate cell migration. Odyssey infrared scanning evaluated this on a macroscopic level, whereas confocal microscopy focused on a more microscopic approach. The expression of proteases released into the culture med

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18

Diaza, Angela Maria Gonella. "Effect of Peri-Ovulatory Endocrine Milieu in the Oviductal Physiology of Beef Cows: Regulation of the Transcriptome, Tissue Morphology, Cell Proliferation, Extracellular Matrix Remodeling, microRNAs Abundance Profile, and Oviductal Fluid Composition." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-02082017-152246/.

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In cattle, the oviduct plays an important role in the reproductive process. Oviductal secretions characterize the environment where storage and sperm capacitation, fertilization, and early embryo development take place. Because molecular control of bovine oviduct receptivity is poorly understood, this Thesis proposed a model of receptivity based on the manipulation of pre-ovulatory follicle growth (POF) used to study the effects of periovulatory endocrine profile on oviductal physiology. Growth of POF in Nelore cows (Bos indicus) was manipulated to produce two groups: cows with large POF and l

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19

Joyce, Belinda Jane. "Elastin synthesis in the fetal sheep lung in vivo : effects of physical, metabolic and endocrine factors." Monash University, Dept. of Physiology, 2004. http://arrow.monash.edu.au/hdl/1959.1/5263.

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20

Marchica, Cinzia Loreta 1984. "Allergen-induced asthma is decreased in decorin-deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116096.

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Decorin, is an extracellular matrix proteoglycan with important biological functions. Decorin deficiency affects collagen fibrillogenesis, airway mechanics, airway-parenchymal interdependence, and airway smooth muscle proliferation and apoptosis. We questioned whether decorin deficiency would alter allergen-induced asthma in a mouse model. Decorin-/- and decorin+/+ mice (C57Bl/6) were sensitized and challenged with ovalbumin. Control animals received saline. Responsiveness was assessed at baseline and after delivery of increasing concentrations of methacholine. Histological analyses were also

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21

Simmers, Phillip Charles. "Benefits of Nitric Oxide Cues to Matrix Synthesis by Healthy and Aneurysmal Human Smooth Muscle Cells within 3D Cocultures." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1399977973.

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22

Yelhekar, Tushar. "Chloride Homeostasis in Central Neurons." Doctoral thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127655.

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The overall aim of the present thesis is to clarify the control of intracellular chloride homeostasis in central neurons, because of the critical role of chloride ions (Cl–) for neuronal function. Normal function of the central nervous system (CNS) depends on a delicate balance between neuronal excitation and inhibition. Inhibition is, in the adult brain, most often mediated by the neurotransmitter γ-aminobutyric acid (GABA). GABA may, however, in some cases cause excitation. GABA acts by activating GABA type A receptors (GABAARs), which are ion channels largely permeable to Cl–. The effect of

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23

Robertson, Ian Butler. "An investigation into the molecular mechanism of the fibrillin1-LTBP1 interaction." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e154e0a2-c0cb-42bd-8b90-7a13460700c0.

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Many studies have demonstrated a connection between the fibrillin matrix and TGFβ signalling, but at present the mechanistic basis for this link is unclear. An interaction between the C-terminus of Latent TGFβ Binding Protein 1 (LTBP1) and the N-terminus of fibrillin1 has previously been identified, and may have the potential to directly link the fibrillin matrix to TGFβ signalling. To investigate the structural basis for this interaction, several multi-domain fragments of fibrillin1 and LTBP1 were expressed prokaryotically and refolded in vitro. After initial characterisation t

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24

Ghannoum, Dima. "Rôle physiologique et physiopathologique de la xylosyltransférase I dans le développement ostéoarticulaire." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0240/document.

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Les protéoglycanes (PGs) sont des protéines présentes au niveau de la matrice extracellulaire et à la surface des cellules. Ils sont constitués d’une protéine sur laquelle sont attachées des chaînes de glycosaminoglycanes. Ils jouent un rôle essentiel dans plusieurs processus biologiques. Des mutations au niveau des gènes codant pour la protéine porteuse ou les enzymes impliquées dans la biosynthèse des GAGs sont associées à plusieurs syndromes et pathologies chez l’homme. L’initiation de la synthèse des GAGs est catalysée par la xylosyltransférase I (XT-I). La XT-I joue un rôle clé dans la ré

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25

Susin, Michelle Fernanda. "Análise funcional das proteínas HrcA, GroES/GroEL e DnaK/DnaJ em Caulobacter crescentus." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-14062016-171416/.

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O operon groESL de C. crescentus apresenta dupla regulação. A indução deste operon por choque térmico é dependente do fator sigma de choque térmico σ32. A temperaturas fisiológicas, a expressão de groESL apresenta regulação temporal durante o ciclo celular da bactéria e o controle envolve a proteína repressora HrcA e o elemento CIRCE (controlling inverted repeat of chaperonin expression). Para estudar a atividade da proteína repressora in vitro, produzimos e purificamos de E. coli a HrcA de C. creseentus contendo uma cauda de histidinas e a ligação especifica ao elemento CIRCE foi analis

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26

Raif, El Mostafa. "Etude des interfaces moléculaires de la matrice extracellulaire de l'os humain mature." Bordeaux 2, 1993. http://www.theses.fr/1993BOR28242.

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27

CoreyAyne, Singleton. "Expression of extracellular matrix proteins during blastulation in bovine embryos and factors affecting bovine endodermal cell outgrowth In Vitro." Thesis, 2002. http://hdl.handle.net/1957/31845.

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During early embryonic development, endodermal cells leave the inner cell mass (ICM) and migrate over an extracellular matrix (ECM), located on the blastocoelic side of the trophectoderm, to form a continuous layer of extraembryonic endoderm. Cell migration events depend on a family of cell surface proteins known as integrins that bind specific ECM proteins. In an effort to understand the mechanisms involved in bovine endodermal cell migration, two experiments were conducted. In the first experiment, expression of the ECM proteins fibronectin, laminin and vitronectin was evaluated by immunoflu

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28

Myler, Heather Ann. "Heparanase and platelet factor-4 induce smooth muscle cell proliferation and migration via basic fibroblast growth factor release from the extracellular matrix: Implications in the restenosis process." Thesis, 2003. http://hdl.handle.net/1911/18597.

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Basic fibroblast growth factor (bFGF) plays an instrumental role in the cascade of events leading to restenosis, vascular re-occlusion due to excessive smooth muscle cell (SMC) proliferation, migration and extracellular matrix (ECM) deposition following arterial intervention procedures such as balloon angioplasty. The mechanism of bFGF activation following vascular injury has remained elusive. bFGF is stored bound to heparan sulfate proteoglycans in the ECM of the arterial media; release from extracellular sequestration may activate bFGF and initiate SMC proliferation and migration. bFGF mobil

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29

De, Angelis Daniel. "Syndecan-1 expression during postnatal tooth and oral mucosa development in 2 day to 6 week old rats." Thesis, 2000. http://hdl.handle.net/2440/110399.

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Aims to observe changes in the expression of syndecan-1 in both the developing epithelium of the rat oral mucosa, and in epithelial cell rests of Malassez in the developing periodontium of normal rat molars, from late crown development through to early eruption.<br>Thesis (M.D.S.) -- University of Adelaide, School of Dentistry, 2001

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30

Shakibaei, M., C. Csaki, S. Nebrich, and A. Mobasheri. "Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis." 2008. http://hdl.handle.net/10454/6181.

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Osteoarthritis is an inflammatory disease of load-bearing synovial joints that is currently treated with drugs that exhibit numerous side effects and are only temporarily effective on pain, the main symptom of the disease. Consequently, there is an acute need for novel, safe and more effective chemotherapeutic agents for the treatment of osteoarthritis and related arthritic diseases. Resveratrol is a phytoalexin stilbene produced naturally by plants including red grapes, peanuts and various berries. Recent research in various cell models has demonstrated that resveratrol is safe and has potent

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31

Costa, Beatriz Maria Pinto Cruz. "Avaliação dos efeitos celulares, humorais e moleculares da administração do teduglutide num modelo animal de anastomose intestinal." Doctoral thesis, 2018. http://hdl.handle.net/10316/80589.

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Tese de doutoramento em Ciências da Saúde, no ramo de Medicina, na especialidade de Cirurgia, apresentada à Faculdade de Medicina da Universidade de Coimbra<br>Despite recent progresses in surgical technique and perioperative care, failure of intestinal anastomotic healing remains one of the most feared complications in digestive surgery, exerting a profound adverse impact on the operative morbidity and mortality rates, oncologic, and functional outcomes and socioeconomic costs. Teduglutide is an enterotrophic analogue of glucagon-like peptide 2 (GLP-2) approved for the pharmacological reh

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